| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000032375 | 0.1800 | 0.066 | 0.0e+00 | 0.261 | 0.282 | 0.293 | 0.290 | 6.6e-29 | 1.9e-31 | 9.1e-33 | 2.2e-32 |
| 2 | Adipose | intron excision ratio | chr6:22136486:22138323 | 0.0258 | 0.018 | 4.5e-03 | 0.006 | 0.014 | 0.008 | 0.011 | 6.0e-02 | 9.2e-03 | 3.9e-02 | 1.8e-02 |
| 3 | Adipose | mRNA stability | ENSRNOG00000032375 | 0.0650 | 0.037 | 2.3e-06 | 0.057 | 0.050 | 0.055 | 0.055 | 5.8e-07 | 3.0e-06 | 1.0e-06 | 9.0e-07 |
| 4 | Eye | gene expression | ENSRNOG00000032375 | 0.5800 | 0.160 | 2.9e-04 | -0.019 | 0.080 | -0.006 | 0.001 | 8.0e-01 | 2.4e-02 | 4.1e-01 | 3.2e-01 |
| 5 | LHb | alternative polyA | ENSRNOT00000047853 | 0.3000 | 0.146 | 3.3e-03 | 0.112 | 0.065 | 0.064 | 0.078 | 1.3e-03 | 1.2e-02 | 1.3e-02 | 6.6e-03 |
| 6 | LHb | alternative polyA | ENSRNOT00000111503 | 0.3390 | 0.154 | 1.6e-03 | 0.078 | 0.076 | 0.071 | 0.081 | 6.7e-03 | 7.4e-03 | 9.2e-03 | 5.9e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Time >=10cm from walls, locomotor time 1 | 4.2 | 4.2 | 8.3 | -0.9 | -2.8 | 2.3 | -2.9 | 1.2 | -1.2 |
| Retroperitoneal fat weight | 3.8 | 12.5 | 33.5 | 1.3 | -0.6 | 2.0 | 1.5 | 5.8 | -5.8 |
| Heart weight | 3.0 | 4.3 | 9.6 | 1.2 | -0.2 | 2.1 | 0.4 | 3.1 | -3.1 |
| Reaction time num false alarms AUC | 2.9 | 4.1 | 8.7 | -2.7 | -2.8 | 0.6 | -3.0 | -0.2 | 0.2 |
| Intermitt. access day 15 inactive lever presses | 2.9 | 3.2 | 6.9 | 1.8 | 2.6 | -1.6 | 2.5 | -0.5 | 0.5 |
| Reaction time num false alarms | 2.8 | 3.9 | 8.7 | -2.4 | -2.8 | 0.9 | -3.0 | -0.1 | 0.1 |
| Intermittent access day 1 locomotion | 2.7 | 2.8 | 7.7 | -0.3 | 1.7 | -2.8 | 1.8 | -1.2 | 1.2 |
| Bouts of movement, locomotor time 2 | 2.6 | 2.7 | 5.5 | -1.6 | -2.3 | 1.5 | -2.0 | 1.1 | -1.1 |
| Conditioned reinforcement - inactives | 2.5 | 2.8 | 6.5 | 0.5 | 2.1 | -2.6 | 2.1 | -0.7 | 0.7 |
| Lifetime Intake | 2.5 | 2.7 | 7.7 | -0.1 | 1.3 | -2.8 | 0.9 | -1.8 | 1.8 |
| Short access day 10 total infusions | 2.5 | 2.8 | 5.1 | 0.0 | 1.3 | -2.3 | 0.6 | -2.2 | 2.2 |
| Short access total infusions | 2.5 | 2.8 | 6.3 | 0.5 | 1.6 | -2.5 | 1.0 | -1.8 | 1.8 |
| Delay disc. indifference point, 24s delay | 2.5 | 2.4 | 6.2 | -1.1 | 0.0 | -0.6 | -0.7 | -2.5 | 2.5 |
| Time in novel zone, NPP test | 2.4 | 2.5 | 5.1 | 0.5 | -0.8 | 1.9 | -0.3 | 2.3 | -2.3 |
| Delta time in open arm before/after self-admin | 2.4 | 2.3 | 4.5 | 0.7 | 2.1 | -1.5 | 1.9 | -1.2 | 1.2 |
| Co content in liver | 2.4 | 2.8 | 5.8 | -2.4 | -1.8 | 0.6 | -2.3 | -1.1 | 1.1 |
| Novelty place preference | 2.3 | 2.4 | 5.0 | 0.6 | -0.8 | 1.8 | -0.2 | 2.2 | -2.2 |
| Intermittent access day 1 total infusions | 2.2 | 2.5 | 7.4 | -0.8 | 1.2 | -2.7 | 0.9 | -1.5 | 1.5 |
| Bone: cortical porosity | 2.2 | 2.4 | 7.9 | 0.3 | -1.4 | 2.8 | -2.1 | -0.1 | 0.1 |
| Conditioned locomotion | 2.1 | 2.5 | 5.4 | 1.1 | 2.2 | -1.8 | 2.3 | -0.4 | 0.4 |
| Short access day 1 locomotion | 2.1 | 2.2 | 5.4 | 0.1 | 1.5 | -2.3 | 1.5 | -1.4 | 1.4 |
| Short access total locomotion | 2.1 | 2.1 | 4.4 | 0.8 | 1.8 | -2.1 | 1.9 | -0.6 | 0.6 |
| Novel to familiar place preference ratio | 2.1 | 2.2 | 4.7 | 0.5 | -0.7 | 1.8 | -0.2 | 2.2 | -2.2 |
| Bone: cortical porosity | 2.1 | 2.2 | 6.3 | 0.3 | -1.4 | 2.5 | -2.2 | -0.4 | 0.4 |
| Light reinforcement 1 | 2.0 | 3.7 | 7.6 | -1.1 | 1.4 | -2.8 | 1.0 | -2.2 | 2.2 |
| Conditioned reinforcement - actives | 1.9 | 1.9 | 4.9 | 0.4 | 1.4 | -2.2 | 1.4 | -1.0 | 1.0 |
| Intermittent access day 15 total locomotion | 1.9 | 2.0 | 5.7 | -0.2 | 1.2 | -2.4 | 1.1 | -1.3 | 1.3 |
| Short access day 1 total inactive lever presses | 1.9 | 2.1 | 6.9 | -0.4 | 1.3 | -2.6 | 1.4 | -0.9 | 0.9 |
| Locomotion velocity, session 7 | 1.9 | 2.1 | 3.7 | -1.9 | -0.6 | -1.3 | -0.9 | -1.7 | 1.7 |
| Active lever presses in extinction session 6 | 1.9 | 1.8 | 3.6 | 1.6 | 1.9 | -1.0 | 1.6 | -0.8 | 0.8 |
| Total resting periods, locomotor time 2 | 1.9 | 2.0 | 4.1 | -1.5 | -2.0 | 1.0 | -1.6 | 0.9 | -0.9 |
| Reaction time false alarm rate | 1.8 | 2.5 | 5.4 | -2.3 | -2.2 | 0.0 | -2.2 | -0.5 | 0.5 |
| Intermittent access total infusions | 1.8 | 2.0 | 6.6 | -0.4 | 1.0 | -2.6 | 0.7 | -1.3 | 1.3 |
| Progressive ratio test 1 breakpoint | 1.8 | 1.9 | 7.7 | -0.3 | 1.2 | -2.8 | 1.4 | -0.2 | 0.2 |
| Short access day 10 total inactive lever presses | 1.8 | 2.0 | 4.1 | 2.0 | 2.0 | 0.4 | 1.9 | 0.4 | -0.4 |
| Fecal boli incidents, locomotor time 1 | 1.8 | 1.9 | 5.5 | -0.3 | -1.4 | 2.3 | -1.7 | 0.7 | -0.7 |
| Mg content in liver | 1.8 | 1.9 | 3.4 | 0.7 | 1.9 | -1.4 | 1.8 | -0.9 | 1.0 |
| Epididymis fat weight | 1.7 | 3.9 | 9.4 | 1.1 | -0.5 | 1.6 | 0.5 | 3.1 | -3.1 |
| Liver weight, right | 1.7 | 2.7 | 7.3 | 0.2 | -1.2 | 0.7 | -0.2 | 2.7 | -2.7 |
| Progressive ratio test 1 active lever presses | 1.7 | 1.7 | 6.7 | -0.2 | 1.3 | -2.6 | 1.4 | -0.3 | 0.3 |
| Bone: trabecular number | 1.7 | 2.6 | 6.1 | 1.2 | 1.3 | -0.4 | 0.3 | -2.5 | 2.5 |
| Seeking ratio, delayed vs. immediate footshock | 1.7 | 1.9 | 4.0 | 0.9 | 1.9 | -1.6 | 2.0 | -0.4 | 0.4 |
| Mean num. licks in bursts | 1.6 | 1.9 | 3.0 | 1.5 | 1.5 | -0.2 | 0.9 | -1.7 | 1.7 |
| Social time | 1.6 | 2.1 | 3.9 | 1.7 | 2.0 | -1.0 | 1.9 | -0.7 | 0.7 |
| Short access day 10 total locomotion | 1.6 | 1.8 | 3.2 | 0.3 | 1.5 | -1.8 | 1.6 | -1.2 | 1.2 |
| Time in familiar zone, hab. session 2 | 1.6 | 1.7 | 2.5 | 1.1 | 1.5 | -0.9 | 0.8 | -1.6 | 1.6 |
| Time in open arm before self-admin | 1.6 | 1.7 | 4.1 | -0.9 | -1.6 | 1.6 | -2.0 | 0.3 | -0.3 |
| Time to tail flick, vehicle, before self-admin | 1.6 | 1.6 | 2.5 | -0.6 | -1.6 | 0.7 | -1.3 | 1.6 | -1.6 |
| Food seeking constrained by brief footshock | 1.6 | 2.0 | 5.1 | 0.4 | 0.8 | -1.0 | -0.1 | -2.3 | 2.3 |
| Na content in liver | 1.6 | 1.7 | 3.3 | 0.8 | 1.8 | -1.4 | 1.8 | -0.8 | 0.8 |
| Times rat made contact with spout | 1.5 | 1.7 | 4.6 | -0.5 | 0.4 | -0.8 | 0.0 | -2.1 | 2.1 |
| One hour access (shock baseline) | 1.5 | 1.7 | 5.6 | -0.4 | 0.6 | -2.4 | 0.4 | -1.4 | 1.4 |
| Bone: apparent density | 1.5 | 2.6 | 6.5 | 1.0 | 1.1 | -0.5 | 0.1 | -2.5 | 2.5 |
| Bone: connectivity density | 1.5 | 2.3 | 6.3 | 0.8 | 0.9 | -0.1 | -0.2 | -2.5 | 2.5 |
| Intraocular pressure | 1.4 | 2.0 | 4.5 | -0.2 | -1.8 | 2.0 | -2.1 | 0.4 | -0.4 |
| Intermittent access total locomotion | 1.4 | 1.6 | 5.4 | 0.0 | 1.2 | -2.3 | 1.4 | -0.6 | 0.6 |
| Locomotion in novel chamber post-restriction | 1.4 | 1.7 | 4.2 | 0.2 | -0.7 | 1.0 | -0.4 | 2.1 | -2.1 |
| Extensor digitorum longus weight | 1.3 | 5.2 | 9.7 | -1.8 | 0.9 | -2.7 | 0.6 | -3.1 | 3.1 |
| Soleus weight | 1.3 | 3.8 | 8.3 | -2.9 | -0.6 | -1.6 | -0.8 | -2.4 | 2.4 |
| Indifference point AUC | 1.3 | 1.5 | 2.7 | -0.5 | 0.8 | -1.5 | 0.6 | -1.6 | 1.6 |
| Pavlov. Cond. intertrial magazine entries | 1.3 | 1.6 | 3.0 | 1.7 | 0.6 | 1.1 | 1.0 | 1.5 | -1.5 |
| Intermittent access terminal intake (last 3 days) | 1.3 | 1.4 | 5.5 | 0.0 | 0.7 | -2.3 | 0.6 | -1.0 | 1.0 |
| Progressive ratio test 1 inactive lever presses | 1.3 | 1.4 | 4.6 | -0.3 | 1.1 | -2.1 | 1.1 | -0.8 | 0.8 |
| Short access day 1 total infusions | 1.3 | 1.4 | 4.1 | -0.2 | 0.9 | -2.0 | 0.7 | -1.2 | 1.2 |
| Locomotion velocity, session 8 | 1.3 | 1.6 | 2.8 | 0.4 | 1.0 | -1.6 | 0.6 | -1.7 | 1.7 |
| Diff in mean of infusions in LGA sessions | 1.3 | 1.4 | 3.3 | 1.5 | 1.8 | -0.7 | 1.6 | -0.0 | 0.0 |
| Total resting periods, locomotor time 1 | 1.3 | 1.4 | 2.2 | -1.4 | -1.0 | 0.1 | -1.5 | -1.3 | 1.3 |
| Progressive ratio | 1.3 | 1.5 | 2.8 | 1.2 | 1.7 | -0.9 | 1.6 | -0.9 | 0.9 |
| Seeking ratio, punishment vs. effort | 1.3 | 1.6 | 4.5 | -1.1 | -1.7 | 0.8 | -2.1 | -0.0 | 0.0 |
| Delay discounting water rate 12 sec | 1.2 | 1.8 | 3.1 | 0.5 | -1.1 | 1.4 | -1.1 | 1.8 | -1.8 |
| Degree of sensitization distance | 1.2 | 1.2 | 2.0 | -0.6 | -1.4 | 0.9 | -1.1 | 1.2 | -1.2 |
| Time in novel zone, hab. session 2 | 1.2 | 1.2 | 2.4 | -0.7 | -1.1 | 0.8 | -0.4 | 1.5 | -1.5 |
| Delta time in closed arm before/after self-admin | 1.2 | 1.1 | 3.9 | 0.1 | -0.9 | 2.0 | -1.0 | 0.7 | -0.7 |
| Total heroin consumption | 1.2 | 1.5 | 3.6 | 1.2 | 1.9 | -0.6 | 1.5 | -0.8 | 0.8 |
| Delay disc. indifference point, 0s delay | 1.2 | 1.3 | 1.9 | -0.3 | -1.3 | 1.4 | -1.3 | 1.0 | -1.0 |
| Delay discount exponential model param | 1.2 | 1.3 | 3.0 | 0.8 | 0.4 | 0.0 | 0.9 | 1.7 | -1.7 |
| Change in fecal boli incidents, locomotor task | 1.2 | 1.2 | 2.4 | -1.0 | -1.1 | -0.1 | -0.2 | 1.5 | -1.5 |
| Latency to leave start box in cocaine runway, F | 1.2 | 1.3 | 3.3 | -0.6 | 0.1 | -0.8 | -0.4 | -1.8 | 1.8 |
| Social responses | 1.1 | 1.5 | 4.6 | 0.3 | 1.5 | -1.4 | 2.1 | -0.1 | 0.1 |
| Conditioned locomotion | 1.1 | 1.3 | 2.7 | -0.8 | -0.6 | 0.0 | -1.1 | -1.6 | 1.6 |
| Stereotopy head waving bouts, day 3 | 1.1 | 1.3 | 2.6 | 0.3 | 1.0 | -1.0 | 0.6 | -1.6 | 1.6 |
| Extinction: sum of active levers before priming | 1.1 | 1.1 | 2.7 | -1.7 | -1.4 | 0.6 | -1.3 | 0.1 | -0.1 |
| Delay discount hyperbolic model param | 1.1 | 1.2 | 3.0 | 0.6 | 0.3 | 0.1 | 0.8 | 1.7 | -1.7 |
| Bouts of movement, locomotor time 1 | 1.1 | 1.2 | 2.3 | -1.5 | -0.7 | -0.5 | -1.0 | -1.2 | 1.2 |
| Time >=10cm from walls, locomotor time 2 | 1.1 | 1.1 | 2.1 | 1.2 | 0.0 | 1.1 | 0.4 | 1.4 | -1.4 |
| Reaction time mean minus median | 1.0 | 1.2 | 3.0 | 1.7 | 1.6 | 0.2 | 1.3 | -0.2 | 0.2 |
| Saline control response | 1.0 | 1.4 | 3.0 | -0.2 | 1.3 | -1.7 | 1.4 | -0.8 | 0.8 |
| Pavlov. Cond. change in total contacts | 1.0 | 1.4 | 2.8 | -1.6 | -1.7 | 0.3 | -1.6 | 0.4 | -0.4 |
| Progressive ratio test 2 inactive lever presses | 1.0 | 1.1 | 2.9 | 0.6 | 1.2 | -1.7 | 1.0 | -0.7 | 0.7 |
| Locomotion velocity, session 3 | 1.0 | 1.2 | 3.1 | 0.0 | 0.6 | -0.6 | -0.2 | -1.8 | 1.8 |
| Condit. Reinf. inactive responses | 1.0 | 1.2 | 2.7 | -1.2 | -1.6 | 0.5 | -1.7 | -0.0 | 0.0 |
| Condit. Reinf. lever presses | 1.0 | 1.3 | 2.7 | -1.5 | -1.3 | 0.6 | -1.6 | -0.7 | 0.7 |
| Bone volume | 1.0 | 1.7 | 3.4 | 1.2 | 1.2 | -0.4 | 0.5 | -1.9 | 1.9 |
| Bone: trabecular spacing | 1.0 | 1.3 | 2.8 | -0.8 | -0.9 | 0.8 | -0.5 | 1.7 | -1.7 |
| Distance traveled after self-admin | 1.0 | 1.2 | 1.7 | -1.3 | -1.2 | 0.4 | -0.7 | 1.3 | -1.3 |
| Time in closed arm after self-admin | 1.0 | 1.1 | 2.9 | -0.3 | -0.6 | -0.2 | 0.2 | 1.7 | -1.7 |
| Time to tail flick, vehicle, after self-admin | 1.0 | 1.1 | 1.9 | 0.7 | 0.7 | 0.2 | 1.3 | 1.4 | -1.4 |
| Ambulatory time before self-admin | 1.0 | 1.0 | 2.4 | -1.5 | -0.3 | -0.9 | 0.3 | 1.2 | -1.2 |
| Delay disc. indifference point, 8s delay | 1.0 | 1.0 | 1.8 | -1.2 | -0.5 | -0.3 | -0.8 | -1.3 | 1.3 |
| Cocaine response before conditioning | 0.9 | 1.1 | 2.3 | -0.3 | 0.8 | -1.5 | 0.8 | -1.2 | 1.2 |
| One hour access (0.3 mA shock) | 0.9 | 1.1 | 2.2 | 0.7 | 0.8 | -1.5 | 0.5 | -1.2 | 1.2 |
| Number of responses in last shaping day | 0.9 | 0.9 | 1.4 | -1.2 | -1.2 | 0.0 | -0.8 | 1.0 | -1.0 |
| Locomotion distance, session 3 | 0.9 | 1.0 | 2.1 | -0.9 | 0.1 | -0.9 | -0.0 | -1.5 | 1.5 |
| Bone surface | 0.9 | 1.7 | 3.5 | 1.1 | 1.2 | -0.2 | 0.5 | -1.9 | 1.9 |
| Bone: cortical tissue density | 0.9 | 1.1 | 2.0 | 1.1 | 1.4 | -1.2 | 1.3 | -0.5 | 0.5 |
| Area under the delay curve | 0.9 | 0.9 | 2.0 | -0.8 | -0.4 | 0.0 | -0.9 | -1.4 | 1.4 |
| Delay disc. indifference point, 4s delay | 0.9 | 0.9 | 2.5 | 0.5 | 0.2 | -0.2 | -0.6 | -1.6 | 1.6 |
| Distance moved, locomotor task time 2 | 0.9 | 1.0 | 1.9 | 1.1 | 1.2 | -0.9 | 1.4 | 0.5 | -0.5 |
| Locomotion in novel chamber | 0.9 | 1.1 | 1.6 | 1.3 | 1.0 | 0.2 | 1.1 | 1.1 | -1.1 |
| Tibialis anterior weight | 0.8 | 2.7 | 4.8 | -1.5 | 0.8 | -2.0 | 0.4 | -2.2 | 2.2 |
| Delay discounting water rate 6 sec | 0.8 | 1.2 | 1.8 | 0.1 | -1.0 | 1.2 | -1.0 | 1.4 | -1.4 |
| Median of all reaction times | 0.8 | 1.1 | 1.7 | 1.3 | 0.2 | 1.3 | 0.2 | 1.3 | -1.3 |
| Std. dev. reaction times | 0.8 | 1.1 | 3.1 | 1.8 | 1.1 | 0.9 | 0.9 | 0.5 | -0.5 |
| Condit. Reinf. active minus inactive responses | 0.8 | 1.0 | 2.6 | -1.6 | -1.3 | 0.3 | -1.1 | 0.1 | -0.1 |
| Condit. Reinf. active-inactive response ratio | 0.8 | 0.9 | 2.1 | -1.4 | -1.2 | 0.1 | -1.2 | -0.1 | 0.1 |
| Pavlov. Cond. lever contacts | 0.8 | 1.1 | 3.0 | -1.7 | -1.4 | -0.2 | -1.3 | -0.2 | 0.2 |
| Pavlov. Cond. response bias | 0.8 | 1.1 | 3.1 | -1.8 | -1.0 | -0.7 | -1.1 | -0.6 | 0.6 |
| Compulsive drug intake | 0.8 | 0.8 | 2.2 | 0.6 | -0.2 | 1.5 | -0.1 | 1.0 | -1.0 |
| Locomotion velocity, session 1 | 0.8 | 0.8 | 1.2 | 1.1 | 1.1 | -0.7 | 0.7 | -0.9 | 0.9 |
| Locomotion distance, session 7 | 0.8 | 1.0 | 2.1 | -1.4 | -1.4 | 0.3 | -1.3 | -0.3 | 0.3 |
| Bone: cortical apparent density | 0.8 | 1.0 | 1.9 | 1.0 | 1.4 | -1.2 | 1.2 | -0.6 | 0.6 |
| Delay disc. indifference point, 16s delay | 0.8 | 0.8 | 2.0 | -0.4 | -0.2 | 0.5 | -0.8 | -1.4 | 1.4 |
| Rest time, locomotor task time 1 | 0.8 | 0.9 | 2.1 | -0.5 | -1.1 | 1.4 | -1.4 | -0.2 | 0.2 |
| Fe content in liver | 0.8 | 0.9 | 3.2 | 1.8 | 1.1 | 0.3 | 0.8 | -0.3 | 0.3 |
| Se content in liver | 0.8 | 1.0 | 2.0 | 0.7 | 1.3 | -1.2 | 1.4 | -0.4 | 0.4 |
| Std. dev. time between licks in bursts | 0.7 | 0.8 | 1.1 | -0.7 | -1.1 | 1.0 | -0.9 | 0.9 | -0.9 |
| Delay discounting total patch changes 18 sec | 0.7 | 0.9 | 1.3 | 0.1 | 1.1 | -1.1 | 1.1 | -0.9 | 0.9 |
| Delay discounting water rate 24 sec | 0.7 | 1.0 | 1.8 | -0.7 | -1.4 | 0.2 | -0.8 | 1.2 | -1.2 |
| Reaction time mean minus median AUC | 0.7 | 0.9 | 2.7 | 1.6 | 0.8 | 1.0 | 0.6 | 0.5 | -0.5 |
| Reaction time mean | 0.7 | 0.9 | 2.1 | 1.5 | 0.6 | 1.0 | 0.5 | 1.0 | -1.0 |
| Reaction time mean AUC | 0.7 | 0.9 | 1.5 | 1.2 | 0.4 | 1.0 | 0.4 | 1.1 | -1.1 |
| Reaction time premature initiation rate | 0.7 | 1.0 | 2.5 | -1.6 | -0.6 | -1.2 | -0.4 | -0.8 | 0.8 |
| Intermittent access intake escalation 2 | 0.7 | 0.7 | 1.4 | 0.8 | -0.7 | 0.4 | -0.3 | 1.2 | -1.2 |
| Intermittent access day 15 total infusions | 0.7 | 0.8 | 3.0 | -0.5 | 0.1 | -1.7 | -0.2 | -0.9 | 0.9 |
| Progressive ratio test 2 active lever presses | 0.7 | 0.8 | 3.4 | 0.1 | 0.8 | -1.8 | 0.8 | -0.2 | 0.2 |
| Progressive ratio test 2 breakpoint | 0.7 | 0.8 | 3.6 | 0.2 | 0.8 | -1.9 | 0.7 | -0.3 | 0.3 |
| Condit. Reinf. active responses | 0.7 | 0.8 | 2.2 | -1.5 | -1.2 | 0.0 | -1.1 | -0.1 | 0.1 |
| Pavlov. Cond. lever latency | 0.7 | 0.9 | 2.4 | 0.5 | -0.1 | 0.3 | 0.4 | 1.6 | -1.6 |
| Distance traveled before self-admin | 0.7 | 0.8 | 1.9 | -1.4 | -0.6 | -0.5 | 0.0 | 1.1 | -1.1 |
| Time to tail flick, test, after self-admin | 0.7 | 0.7 | 1.4 | -0.9 | 0.0 | -1.2 | 0.9 | 0.8 | -0.8 |
| Delta time to tail flick, test, before/after SA | 0.7 | 0.7 | 1.7 | -0.6 | 0.6 | -1.3 | 0.8 | -0.7 | 0.7 |
| Distance moved, locomotor task time 1 | 0.7 | 0.7 | 1.2 | 0.9 | 0.9 | -1.0 | 1.1 | 0.5 | -0.5 |
| Cd content in liver | 0.7 | 0.8 | 2.3 | 0.1 | -0.7 | 1.5 | -0.6 | 0.8 | -0.8 |
| Zn content in liver | 0.7 | 0.7 | 2.5 | -0.3 | 0.7 | -1.6 | 1.0 | -0.3 | 0.3 |
| Tibia length | 0.6 | 1.7 | 3.3 | 0.2 | 0.7 | -1.8 | 1.7 | 1.3 | -1.3 |
| Delay discounting water rate 18 sec | 0.6 | 0.7 | 1.1 | -0.6 | -1.0 | 0.4 | -0.9 | 1.0 | -1.0 |
| Cocaine response after cond. not corrected | 0.6 | 0.7 | 1.8 | 0.3 | 0.4 | -0.3 | -0.3 | -1.3 | 1.3 |
| Total zone transitions, hab. session 1 | 0.6 | 0.9 | 1.9 | 0.1 | -0.4 | 1.4 | -0.2 | 1.3 | -1.3 |
| Time in open arm after self-admin | 0.6 | 0.7 | 1.6 | -0.2 | 0.8 | -0.5 | 0.2 | -1.3 | 1.3 |
| Vertical activity count, locomotor time 2 | 0.6 | 0.6 | 2.0 | 1.4 | 0.8 | 0.3 | 0.8 | 0.4 | -0.4 |
| Latency to leave start box in cocaine runway | 0.6 | 0.7 | 1.5 | 0.4 | 0.6 | -0.7 | 0.2 | -1.2 | 1.2 |
| Glucose | 0.5 | 0.8 | 1.5 | 0.6 | 0.8 | -0.7 | 1.2 | 0.9 | -0.9 |
| Left kidney weight | 0.5 | 1.5 | 2.8 | 1.0 | 1.5 | -1.7 | 1.3 | -0.9 | 0.9 |
| Parametrial fat weight | 0.5 | 0.9 | 1.7 | -0.1 | -0.9 | 0.7 | -0.8 | 1.3 | -1.3 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.6 | 1.6 | -0.2 | 0.4 | -1.3 | 0.2 | -0.9 | 0.9 |
| Intermittent access intake escalation | 0.5 | 0.5 | 1.2 | 0.4 | -1.1 | 0.5 | -1.0 | 0.4 | -0.4 |
| Post-drug Anxiety | 0.5 | 0.5 | 1.5 | 1.2 | 0.9 | 0.0 | 0.9 | 0.1 | -0.1 |
| Stereotopy head waving duration, day 7 | 0.5 | 0.6 | 1.2 | 0.8 | 0.7 | -0.1 | 0.2 | -1.1 | 1.1 |
| Time in novel zone, hab. session 1 | 0.5 | 0.5 | 1.2 | -0.1 | -0.5 | 0.5 | -0.1 | 1.1 | -1.1 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.6 | 1.3 | 0.4 | -0.3 | 0.2 | -0.9 | -1.2 | 1.2 |
| Bone: cortical thickness | 0.5 | 0.6 | 1.8 | -0.4 | -1.0 | 0.8 | -1.3 | -0.2 | 0.2 |
| Bone: trabecular thickness | 0.5 | 0.6 | 1.2 | 0.5 | 0.4 | -0.8 | 0.3 | -1.1 | 1.1 |
| Time in closed arm before self-admin | 0.5 | 0.6 | 2.6 | -0.0 | 0.2 | -1.6 | 0.8 | 0.4 | -0.4 |
| Sum of active levers in priming session hrs 5-6 | 0.5 | 0.5 | 0.8 | 0.9 | 0.9 | 0.2 | 0.7 | -0.7 | 0.7 |
| Delta time to tail flick, vehicle, before/after SA | 0.5 | 0.5 | 1.1 | 0.6 | 1.0 | -0.0 | 1.0 | -0.5 | 0.5 |
| Ambulatory time after self-admin | 0.5 | 0.5 | 1.0 | -0.9 | -0.4 | -0.3 | 0.3 | 1.0 | -1.0 |
| Delay disc. indifference point, 2s delay | 0.5 | 0.6 | 1.2 | 0.0 | -0.5 | 0.1 | -1.0 | -1.1 | 1.1 |
| Weight adjusted by age | 0.5 | 0.6 | 1.3 | -0.2 | 0.2 | -0.8 | -0.4 | -1.1 | 1.1 |
| Mn content in liver | 0.5 | 0.6 | 1.0 | -0.1 | 0.9 | -0.2 | 0.9 | -1.0 | 1.0 |
| Rb content in liver | 0.5 | 0.6 | 1.3 | -0.0 | 0.6 | -0.8 | 0.2 | -1.1 | 1.1 |
| Sr content in liver | 0.5 | 0.5 | 0.8 | -0.8 | -0.5 | -0.6 | 0.0 | 0.9 | -0.9 |
| Body weight | 0.4 | 1.5 | 3.4 | -1.8 | -1.1 | -1.0 | 0.1 | 1.3 | -1.3 |
| Number of licking bursts | 0.4 | 0.5 | 1.9 | -1.4 | -0.7 | -0.6 | -0.4 | 0.1 | -0.1 |
| Water consumed over 24 hours | 0.4 | 0.4 | 1.0 | -0.4 | 0.4 | -0.5 | 0.2 | -1.0 | 1.0 |
| Indifference point function ln k | 0.4 | 0.5 | 1.2 | 0.9 | -0.2 | 1.1 | -0.5 | 0.7 | -0.7 |
| Indifference point function log k | 0.4 | 0.5 | 1.2 | 0.9 | -0.2 | 1.1 | -0.5 | 0.7 | -0.7 |
| Light reinforcement 2 | 0.4 | 0.6 | 1.5 | -0.6 | 0.6 | -1.2 | 0.1 | -0.8 | 0.8 |
| Social response proportion | 0.4 | 0.4 | 0.7 | 0.1 | 0.5 | -0.8 | 0.4 | -0.8 | 0.8 |
| Pavlov. Cond. lever latency | 0.4 | 0.5 | 1.1 | 1.1 | 0.6 | 0.4 | 0.8 | 0.6 | -0.6 |
| Stereotopy head waving duration, day 3 | 0.4 | 0.5 | 0.7 | 0.5 | 0.7 | -0.7 | 0.3 | -0.9 | 0.9 |
| Incentive salience index mean | 0.4 | 0.5 | 1.3 | -1.2 | -0.8 | -0.1 | -0.8 | -0.3 | 0.3 |
| Pavlov. Cond. lever contacts | 0.4 | 0.5 | 1.0 | -0.8 | -0.1 | -0.4 | -0.3 | -1.0 | 1.0 |
| Pavlov. Cond. response bias | 0.4 | 0.4 | 1.2 | -0.3 | 0.3 | -0.4 | -0.0 | -1.1 | 1.1 |
| Bone: final force | 0.4 | 0.6 | 1.3 | 1.1 | 0.5 | 0.9 | -0.2 | -0.8 | 0.8 |
| Bone: final moment | 0.4 | 0.6 | 1.1 | 1.0 | 0.4 | 0.7 | -0.2 | -0.9 | 0.9 |
| Bone: maximum diameter | 0.4 | 0.6 | 0.8 | -0.0 | 0.9 | -0.8 | 0.8 | -0.9 | 0.9 |
| Breakpoint value in progressive ratio session | 0.4 | 0.5 | 1.1 | 0.2 | 1.0 | -0.8 | 1.1 | -0.1 | 0.1 |
| Delta distance traveled before/after self-admin | 0.4 | 0.5 | 1.2 | 1.1 | 0.5 | 0.4 | 0.6 | 0.6 | -0.6 |
| Rest time, locomotor task time 2 | 0.4 | 0.4 | 0.9 | -0.1 | 0.4 | -0.7 | 0.4 | -1.0 | 1.0 |
| Length with tail | 0.3 | 1.2 | 3.0 | -0.8 | -0.8 | 0.1 | 0.2 | 1.7 | -1.7 |
| Reaction time omissions | 0.3 | 0.4 | 1.3 | 0.5 | -0.3 | 1.2 | -0.5 | 0.6 | -0.6 |
| Reaction time premature initiations | 0.3 | 0.5 | 1.7 | -1.3 | -0.7 | -0.4 | -0.6 | -0.2 | 0.2 |
| Cocaine response after cond. corrected | 0.3 | 0.3 | 0.6 | 0.5 | 0.2 | 0.3 | -0.5 | -0.8 | 0.8 |
| Condit. Reinf. active responses | 0.3 | 0.4 | 1.1 | -1.0 | -0.8 | 0.2 | -0.6 | 0.3 | -0.3 |
| Condit. Reinf. lever presses | 0.3 | 0.4 | 1.1 | -1.1 | -0.6 | -0.8 | -0.4 | -0.1 | 0.1 |
| Condit. Reinf. lever reinforcers received | 0.3 | 0.4 | 1.1 | -1.1 | -0.8 | 0.3 | -0.6 | 0.3 | -0.3 |
| Intermittent access intake day 1-15 change | 0.3 | 0.3 | 0.8 | 0.4 | -0.9 | 0.3 | -0.8 | 0.4 | -0.4 |
| Intermitt. access day 1 inactive lever presses | 0.3 | 0.3 | 0.9 | -0.3 | 0.5 | -0.4 | 0.9 | 0.4 | -0.4 |
| Intermitt. access escalation Index | 0.3 | 0.3 | 0.5 | -0.5 | -0.7 | -0.5 | -0.6 | -0.3 | 0.3 |
| Cocaine induced anxiety | 0.3 | 0.4 | 0.9 | 0.5 | 0.7 | -0.6 | 1.0 | -0.2 | 0.2 |
| Incentive Sensitization - Responses | 0.3 | 0.3 | 1.1 | 0.1 | 0.1 | -1.0 | 0.3 | 0.5 | -0.5 |
| Incentive Sensitization - Breakpoint | 0.3 | 0.3 | 1.0 | -0.0 | 0.0 | -1.0 | 0.3 | 0.5 | -0.5 |
| Total sessions with >9 infusions | 0.3 | 0.3 | 0.9 | 0.1 | 0.4 | -0.9 | 0.1 | -0.5 | 0.5 |
| Locomotion distance, session 1 | 0.3 | 0.4 | 0.7 | -0.4 | -0.3 | 0.0 | -0.8 | -0.8 | 0.8 |
| Degree of sensitization stereotypy | 0.3 | 0.3 | 0.8 | -0.2 | -0.6 | 0.9 | -0.6 | 0.4 | -0.4 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.5 | 1.0 | 0.5 | 0.4 | 0.4 | 0.6 | 1.0 | -1.0 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 0.9 | -0.9 | -0.2 | -0.2 | -0.4 | -0.8 | 0.8 |
| Bone: elastic work | 0.3 | 0.4 | 1.0 | -0.6 | -0.6 | 0.2 | -1.0 | -0.6 | 0.6 |
| Run reversals in cocaine runway, males | 0.3 | 0.3 | 1.1 | -1.0 | -0.6 | -0.4 | -0.4 | 0.1 | -0.1 |
| Liver weight, left | 0.2 | 0.4 | 0.9 | -0.2 | -0.2 | -0.6 | 0.1 | 0.9 | -0.9 |
| Mean time between licks in bursts | 0.2 | 0.2 | 0.5 | 0.1 | -0.6 | 0.5 | -0.7 | 0.3 | -0.3 |
| Delay discounting time to switch 0 sec | 0.2 | 0.3 | 0.6 | -0.7 | -0.2 | 0.0 | -0.3 | -0.8 | 0.8 |
| Locomotor activity | 0.2 | 0.3 | 1.1 | 0.2 | -0.2 | 1.0 | -0.6 | 0.4 | -0.4 |
| Locomotor testing rearing | 0.2 | 0.3 | 0.5 | -0.6 | 0.2 | -0.7 | 0.2 | -0.6 | 0.6 |
| Reaction time trials on left | 0.2 | 0.2 | 0.5 | 0.0 | -0.2 | 0.5 | -0.3 | 0.7 | -0.7 |
| Reaction time trials completed | 0.2 | 0.2 | 0.5 | 0.0 | -0.2 | 0.5 | -0.3 | 0.7 | -0.7 |
| Pavlov. Cond. index score | 0.2 | 0.3 | 0.4 | -0.7 | -0.2 | -0.6 | -0.4 | -0.5 | 0.5 |
| Pavlov. Cond. magazine entry number | 0.2 | 0.2 | 0.8 | 0.6 | -0.0 | 0.9 | 0.0 | 0.2 | -0.2 |
| Intermittent access standard deviation | 0.2 | 0.2 | 0.7 | 0.1 | 0.3 | -0.8 | 0.5 | 0.2 | -0.2 |
| Baseline Anxiety | 0.2 | 0.2 | 0.3 | -0.1 | -0.3 | 0.1 | -0.6 | -0.6 | 0.6 |
| Locomotion distance, session 8 | 0.2 | 0.3 | 0.8 | -0.9 | -0.8 | -0.2 | -0.6 | -0.1 | 0.1 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.5 | -0.7 | -0.5 | -0.2 | -0.2 | 0.3 | -0.3 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 0.4 | 0.2 | 0.6 | -0.5 | 0.6 | -0.3 | 0.3 |
| Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.4 | 0.6 | 0.5 | 0.3 | 0.4 | 0.1 | -0.1 |
| Total zone transitions, NPP test | 0.2 | 0.3 | 1.1 | -1.0 | -0.4 | 0.1 | -0.5 | -0.4 | 0.4 |
| Locomotion velocity, NPP test | 0.2 | 0.3 | 0.6 | -0.8 | 0.3 | -0.5 | 0.2 | -0.6 | 0.6 |
| Pavlov. Cond. index score | 0.2 | 0.2 | 0.5 | -0.7 | -0.1 | -0.2 | -0.2 | -0.6 | 0.6 |
| Bone: elastic displacement | 0.2 | 0.2 | 0.7 | -0.6 | -0.6 | 0.1 | -0.8 | -0.2 | 0.2 |
| Bone: post-yield work | 0.2 | 0.2 | 0.5 | -0.3 | 0.5 | -0.6 | 0.7 | -0.1 | 0.1 |
| Bone: tissue strength | 0.2 | 0.2 | 0.3 | 0.2 | -0.4 | 0.5 | -0.4 | 0.4 | -0.4 |
| Bone: trabecular tissue density | 0.2 | 0.3 | 0.7 | 0.6 | 0.8 | -0.4 | 0.8 | -0.1 | 0.1 |
| Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 0.6 | 0.8 | 0.4 | -0.2 | 0.6 | 0.2 | -0.2 |
| Cu content in liver | 0.2 | 0.3 | 0.4 | -0.6 | -0.6 | -0.1 | -0.5 | -0.5 | 0.5 |
| K content in liver | 0.2 | 0.2 | 0.8 | -0.1 | 0.6 | -0.5 | 0.9 | 0.1 | -0.1 |
| BMI with tail | 0.1 | 0.3 | 0.7 | -0.8 | -0.5 | -0.6 | -0.1 | 0.3 | -0.3 |
| BMI without tail | 0.1 | 0.3 | 0.9 | -1.0 | -0.3 | -0.9 | 0.1 | 0.2 | -0.2 |
| Right kidney weight | 0.1 | 0.4 | 0.6 | 0.0 | 0.2 | -0.8 | 0.6 | 0.8 | -0.8 |
| Tail length | 0.1 | 0.3 | 0.5 | -0.4 | 0.0 | -0.4 | 0.6 | 0.7 | -0.7 |
| Length without tail | 0.1 | 0.1 | 0.3 | -0.3 | -0.4 | 0.1 | -0.1 | 0.5 | -0.5 |
| Food consumed during 24 hour testing period | 0.1 | 0.1 | 0.3 | -0.3 | -0.5 | 0.5 | -0.3 | 0.3 | -0.3 |
| Indifference point 0 sec | 0.1 | 0.2 | 0.4 | 0.7 | 0.5 | 0.1 | 0.3 | -0.4 | 0.4 |
| Delay discounting total patch changes 12 sec | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.1 | -0.3 | -0.2 | 0.2 |
| Delay discounting total patch changes 6 sec | 0.1 | 0.2 | 0.5 | -0.7 | -0.4 | -0.1 | -0.5 | -0.4 | 0.4 |
| Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.2 | 0.5 | -0.2 | 0.3 | -0.5 | 0.4 | -0.4 |
| Locomotor testing distance | 0.1 | 0.1 | 0.5 | -0.1 | 0.0 | 0.7 | -0.4 | -0.1 | 0.1 |
| Reaction time number correct | 0.1 | 0.2 | 0.4 | -0.0 | -0.2 | 0.5 | -0.3 | 0.7 | -0.7 |
| Reaction time trials correct on left | 0.1 | 0.2 | 0.4 | -0.0 | -0.2 | 0.5 | -0.3 | 0.7 | -0.7 |
| Reaction time trials AUC | 0.1 | 0.1 | 0.2 | 0.2 | 0.1 | 0.3 | -0.1 | 0.4 | -0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.4 | -0.5 | -0.1 | -0.6 | -0.2 | -0.3 | 0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.2 | 0.2 | -0.5 | -0.3 | -0.4 | -0.5 | -0.3 | 0.3 |
| Stereotopy head waving bouts, day 7 | 0.1 | 0.1 | 0.5 | 0.7 | 0.3 | 0.3 | 0.2 | -0.1 | 0.1 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.2 | 0.4 | -0.1 | 0.3 | -0.2 | 0.5 | 0.6 | -0.6 |
| Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.4 | 0.3 | 0.0 | 0.6 | -0.3 | -0.3 | 0.3 |
| Total locomotion distance, hab. session 2 | 0.1 | 0.1 | 0.2 | -0.0 | 0.4 | -0.2 | 0.5 | -0.1 | 0.1 |
| Locomotion velocity, hab. session 2 | 0.1 | 0.1 | 0.1 | -0.2 | 0.3 | -0.2 | 0.3 | -0.3 | 0.3 |
| Total locomotion distance, NPP test | 0.1 | 0.1 | 0.7 | -0.9 | -0.3 | 0.2 | -0.2 | 0.1 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.2 | 0.8 | -0.9 | -0.2 | -0.3 | -0.1 | -0.2 | 0.2 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.5 | -0.7 | -0.3 | -0.2 | -0.2 | 0.1 | -0.1 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.5 | -0.7 | -0.2 | -0.0 | -0.3 | -0.5 | 0.5 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.2 | 0.4 | -0.0 | 0.3 | -0.1 | 0.3 | -0.3 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.3 | 0.1 | -0.3 | 0.3 | -0.2 | 0.6 | -0.6 |
| Bone: endosteal estimation | 0.1 | 0.3 | 0.8 | -0.2 | 0.4 | -0.3 | 0.2 | -0.9 | 0.9 |
| Bone: endosteal perimeter | 0.1 | 0.3 | 0.6 | -0.3 | 0.6 | -0.5 | 0.8 | -0.4 | 0.4 |
| Bone: marrow area | 0.1 | 0.3 | 0.7 | -0.3 | 0.3 | -0.3 | 0.2 | -0.9 | 0.9 |
| Bone: maximum force | 0.1 | 0.1 | 0.5 | 0.5 | 0.2 | 0.7 | 0.0 | -0.1 | 0.1 |
| Bone: minimum diameter | 0.1 | 0.2 | 0.6 | 0.0 | 0.4 | -0.2 | 0.3 | -0.8 | 0.8 |
| Bone: periosteal estimation | 0.1 | 0.3 | 0.7 | -0.3 | 0.4 | -0.4 | 0.3 | -0.8 | 0.8 |
| Bone: periosteal perimeter | 0.1 | 0.1 | 0.7 | -0.8 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 |
| Bone: stiffness | 0.1 | 0.1 | 0.5 | 0.0 | -0.4 | 0.7 | -0.3 | 0.3 | -0.3 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.2 | 0.5 | 0.7 | 0.4 | 0.1 | 0.3 | -0.2 | 0.2 |
| Time to tail flick, test, before self-admin | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | -0.2 | 0.0 | 0.4 | -0.4 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | -0.5 | 0.5 | 0.4 | -0.4 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.2 | -0.2 | 0.1 | -0.2 | 0.4 | 0.5 | -0.5 |
| Delay discounting total patch changes 0 sec | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.0 | -0.1 | 0.1 |
| Delay discounting total patch changes 24 sec | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | -0.1 | 0.5 | -0.1 | 0.1 |
| Condit. Reinf. inactive responses | 0.0 | 0.1 | 0.2 | -0.5 | -0.3 | 0.1 | -0.2 | -0.1 | 0.1 |
| Context. condit. distance diff. score | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.2 | 0.1 | 0.2 | -0.2 |
| Locomotion velocity, session 2 | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | 0.2 | -0.3 | -0.2 | 0.2 |
| Locomotion distance, session 2 | 0.0 | 0.1 | 0.2 | -0.2 | -0.3 | 0.2 | -0.5 | -0.0 | 0.0 |
| Bone: cortical area | 0.0 | 0.1 | 0.1 | -0.2 | 0.1 | -0.3 | 0.1 | -0.4 | 0.4 |
| Bone: maximum moment | 0.0 | 0.1 | 0.2 | 0.4 | 0.1 | 0.4 | -0.1 | -0.3 | 0.3 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.