| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000031950 | 0.370 | 0.150 | 0.0e+00 | 0.269 | 0.271 | 0.271 | 0.272 | 8.1e-30 | 5.1e-30 | 4.9e-30 | 3.3e-30 |
| 2 | BLA | gene expression | ENSRNOG00000031950 | 0.258 | 0.173 | 1.8e-04 | 0.069 | 0.062 | 0.074 | 0.067 | 1.5e-04 | 3.1e-04 | 8.2e-05 | 1.9e-04 |
| 3 | BLA | isoform ratio | ENSRNOT00000113785 | 0.088 | 0.059 | 4.6e-06 | 0.102 | 0.102 | 0.093 | 0.104 | 4.1e-06 | 4.0e-06 | 1.2e-05 | 3.4e-06 |
| 4 | BLA | isoform ratio | ENSRNOT00000115800 | 0.055 | 0.039 | 3.7e-04 | 0.078 | 0.068 | 0.073 | 0.066 | 5.5e-05 | 1.6e-04 | 9.3e-05 | 2.1e-04 |
| 5 | BLA | intron excision ratio | chr7:9008225:9008446 | 0.041 | 0.034 | 5.7e-03 | 0.033 | 0.031 | 0.032 | 0.025 | 6.7e-03 | 9.1e-03 | 8.1e-03 | 1.7e-02 |
| 6 | Brain | gene expression | ENSRNOG00000031950 | 0.190 | 0.110 | 1.4e-07 | 0.043 | 0.074 | 0.065 | 0.073 | 7.0e-05 | 2.2e-07 | 1.2e-06 | 2.7e-07 |
| 7 | NAcc | gene expression | ENSRNOG00000031950 | 0.470 | 0.180 | 1.0e-05 | 0.080 | 0.052 | 0.059 | 0.074 | 1.4e-06 | 9.4e-05 | 3.5e-05 | 3.3e-06 |
| 8 | OFC | isoform ratio | ENSRNOT00000115800 | 0.150 | 0.110 | 1.8e-03 | 0.119 | 0.096 | 0.096 | 0.110 | 9.5e-04 | 2.8e-03 | 2.8e-03 | 1.4e-03 |
| 9 | PL | gene expression | ENSRNOG00000031950 | 0.284 | 0.132 | 7.6e-08 | 0.071 | 0.102 | 0.111 | 0.111 | 4.2e-06 | 3.5e-08 | 9.5e-09 | 8.6e-09 |
| 10 | PL | isoform ratio | ENSRNOT00000113785 | 0.039 | 0.033 | 7.8e-04 | 0.041 | 0.039 | 0.033 | 0.040 | 4.6e-04 | 5.9e-04 | 1.4e-03 | 5.3e-04 |
| 11 | PL | isoform ratio | ENSRNOT00000115800 | 0.051 | 0.053 | 9.6e-04 | 0.033 | 0.028 | 0.038 | 0.035 | 1.5e-03 | 3.0e-03 | 7.0e-04 | 1.1e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Soleus weight | 7.6 | 22.1 | 27.6 | 5.1 | 4.3 | -5.2 | 5.2 | -5.2 | 3.7 | 5.0 | 4.9 | 0.8 | -5.3 | 5.1 |
| Social responses | 6.8 | 8.7 | 11.6 | -3.3 | -3.1 | 2.9 | -2.8 | 2.8 | -2.8 | -3.3 | -3.4 | -1.4 | 2.8 | -3.3 |
| Cocaine response after cond. not corrected | 6.2 | 6.9 | 10.8 | 3.0 | 3.1 | -2.1 | 2.1 | -2.1 | 3.3 | 3.0 | 3.0 | 1.9 | -2.0 | 2.7 |
| Conditioned locomotion | 6.2 | 7.4 | 10.0 | -3.1 | -2.3 | 3.1 | -2.9 | 2.9 | -2.0 | -2.8 | -3.0 | -0.2 | 2.9 | -3.2 |
| BMI with tail | 5.9 | 19.2 | 23.7 | 4.8 | 4.4 | -4.5 | 4.5 | -4.6 | 3.6 | 4.8 | 4.9 | 1.4 | -4.7 | 4.8 |
| Intermittent access intake escalation 2 | 5.8 | 5.7 | 10.1 | -2.4 | -1.4 | 3.2 | -3.1 | 2.9 | -0.7 | -2.1 | -2.2 | 1.2 | 3.0 | -2.7 |
| Cocaine response after cond. corrected | 5.7 | 6.4 | 9.9 | 2.9 | 3.0 | -2.1 | 2.1 | -2.0 | 3.1 | 2.9 | 2.9 | 1.9 | -2.0 | 2.6 |
| Intermittent access intake day 1-15 change | 5.3 | 5.3 | 7.5 | -2.6 | -1.9 | 2.7 | -2.6 | 2.5 | -1.4 | -2.4 | -2.4 | 0.2 | 2.6 | -2.7 |
| Delay disc. indifference point, 0s delay | 5.2 | 5.7 | 10.1 | 2.2 | 1.1 | -3.2 | 3.2 | -3.1 | 0.0 | 1.9 | 1.9 | -1.9 | -3.0 | 2.7 |
| Light reinforcement 1 | 5.1 | 9.3 | 11.4 | -3.3 | -3.0 | 3.2 | -3.2 | 3.1 | -2.8 | -3.4 | -3.3 | -0.9 | 3.2 | -3.3 |
| Locomotion velocity, session 3 | 5.0 | 5.8 | 8.2 | -2.6 | -2.1 | 2.7 | -2.7 | 2.9 | -1.5 | -2.5 | -2.5 | -0.1 | 2.8 | -2.8 |
| Stereotopy head waving duration, day 3 | 4.9 | 6.0 | 7.2 | -2.7 | -2.4 | 2.5 | -2.5 | 2.6 | -2.1 | -2.7 | -2.6 | -0.6 | 2.7 | -2.6 |
| Intermittent access intake escalation | 4.6 | 4.5 | 8.0 | -2.2 | -1.3 | 2.8 | -2.6 | 2.6 | -0.6 | -1.9 | -2.0 | 1.1 | 2.6 | -2.5 |
| Time in familiar zone, hab. session 2 | 4.6 | 4.8 | 7.9 | -2.1 | -1.4 | 2.8 | -2.8 | 2.8 | -0.6 | -1.9 | -2.0 | 0.9 | 2.8 | -2.4 |
| Extensor digitorum longus weight | 4.4 | 17.7 | 22.6 | 4.6 | 4.5 | -4.0 | 4.1 | -4.1 | 4.1 | 4.7 | 4.7 | 1.9 | -4.2 | 4.5 |
| Locomotion velocity, session 2 | 4.4 | 5.2 | 9.2 | -2.4 | -2.7 | 1.6 | -1.5 | 1.7 | -3.0 | -2.5 | -2.5 | -2.6 | 1.7 | -2.0 |
| Stereotopy head waving bouts, day 3 | 4.3 | 5.1 | 6.3 | -2.5 | -2.3 | 2.3 | -2.2 | 2.3 | -2.3 | -2.5 | -2.5 | -0.8 | 2.4 | -2.4 |
| Seeking ratio, delayed vs. immediate footshock | 4.3 | 4.9 | 6.6 | -2.5 | -2.3 | 2.2 | -2.1 | 2.1 | -2.0 | -2.5 | -2.5 | -0.8 | 2.1 | -2.6 |
| Delay disc. indifference point, 2s delay | 4.2 | 4.7 | 7.7 | 2.2 | 1.5 | -2.8 | 2.8 | -2.6 | 0.9 | 2.1 | 2.0 | -0.8 | -2.7 | 2.4 |
| Breakpoint value in progressive ratio session | 4.0 | 4.5 | 7.3 | -2.2 | -1.5 | 2.7 | -2.6 | 2.5 | -1.0 | -2.0 | -2.1 | 0.7 | 2.5 | -2.4 |
| Locomotor activity | 3.9 | 6.1 | 8.6 | -2.9 | -2.9 | 2.1 | -2.1 | 1.9 | -2.8 | -2.9 | -2.9 | -1.5 | 2.1 | -2.7 |
| Condit. Reinf. active responses | 3.5 | 4.2 | 5.4 | -2.3 | -2.2 | 1.9 | -1.9 | 2.0 | -2.3 | -2.3 | -2.3 | -1.2 | 1.9 | -2.1 |
| Condit. Reinf. active minus inactive responses | 3.4 | 3.8 | 5.0 | -2.1 | -1.8 | 2.2 | -2.1 | 2.2 | -1.5 | -2.0 | -2.1 | -0.4 | 2.1 | -2.2 |
| Mean time between licks in bursts | 3.3 | 4.6 | 6.9 | -2.2 | -1.6 | 2.6 | -2.6 | 2.6 | -1.1 | -2.1 | -2.1 | 0.5 | 2.6 | -2.4 |
| Time in novel zone, hab. session 2 | 3.3 | 3.3 | 5.8 | 1.7 | 1.0 | -2.4 | 2.4 | -2.4 | 0.4 | 1.5 | 1.6 | -1.0 | -2.4 | 1.9 |
| Short access day 10 total locomotion | 3.2 | 3.5 | 5.0 | -2.1 | -1.5 | 2.2 | -2.2 | 2.1 | -1.0 | -1.9 | -2.0 | 0.3 | 2.0 | -2.2 |
| Novel to familiar place preference ratio | 3.0 | 3.2 | 6.5 | 1.5 | 0.7 | -2.3 | 2.3 | -2.4 | 0.1 | 1.3 | 1.4 | -1.4 | -2.6 | 1.8 |
| Intermittent access day 15 total locomotion | 2.7 | 2.9 | 4.2 | -1.9 | -1.3 | 2.1 | -1.9 | 1.9 | -1.1 | -1.7 | -1.8 | 0.1 | 2.0 | -1.9 |
| Mn content in liver | 2.7 | 3.1 | 7.6 | -1.8 | -2.4 | 0.5 | -0.4 | 0.5 | -2.6 | -1.9 | -2.0 | -2.8 | 0.5 | -1.5 |
| BMI without tail | 2.6 | 5.5 | 7.7 | 2.7 | 2.7 | -1.9 | 1.9 | -2.1 | 2.8 | 2.7 | 2.7 | 1.8 | -2.0 | 2.3 |
| Liver weight, left | 2.6 | 4.1 | 5.6 | 2.4 | 2.3 | -1.9 | 1.9 | -1.8 | 1.8 | 2.4 | 2.4 | 0.9 | -1.8 | 2.3 |
| Active lever presses in extinction session 6 | 2.6 | 2.5 | 3.4 | -1.8 | -1.6 | 1.8 | -1.6 | 1.4 | -1.4 | -1.6 | -1.7 | -0.4 | 1.5 | -1.8 |
| Locomotion distance, session 2 | 2.5 | 3.6 | 9.2 | -1.9 | -2.3 | 1.0 | -0.9 | 1.0 | -3.0 | -2.0 | -2.0 | -2.6 | 1.0 | -1.4 |
| Bone volume | 2.5 | 4.2 | 12.4 | -1.8 | -2.9 | -0.3 | 0.4 | -0.3 | -3.2 | -2.1 | -2.1 | -3.5 | -0.3 | -1.4 |
| Bone: trabecular thickness | 2.5 | 3.0 | 10.4 | -1.3 | -2.3 | -0.7 | 0.7 | -0.7 | -2.8 | -1.6 | -1.6 | -3.2 | -0.7 | -0.8 |
| Tail length | 2.4 | 7.4 | 11.1 | -2.9 | -2.2 | 3.2 | -3.2 | 3.1 | -1.4 | -2.7 | -2.8 | 0.3 | 3.3 | -3.1 |
| Delta time in closed arm before/after self-admin | 2.4 | 2.3 | 6.1 | 1.4 | 2.1 | -0.4 | 0.3 | -0.4 | 2.4 | 1.6 | 1.6 | 2.5 | -0.4 | 1.1 |
| Total locomotion distance, hab. session 1 | 2.3 | 3.3 | 7.9 | -1.8 | -2.4 | 0.6 | -0.6 | 0.7 | -2.8 | -2.0 | -2.0 | -2.8 | 0.6 | -1.4 |
| Locomotion velocity, hab. session 1 | 2.3 | 3.3 | 7.7 | -1.9 | -2.3 | 1.0 | -1.0 | 1.0 | -2.8 | -2.0 | -2.0 | -2.4 | 0.9 | -1.5 |
| Bone surface | 2.3 | 4.1 | 12.4 | -1.8 | -2.8 | -0.3 | 0.4 | -0.2 | -3.2 | -2.1 | -2.1 | -3.5 | -0.3 | -1.4 |
| Locomotor testing distance | 2.2 | 3.6 | 5.0 | -2.2 | -2.1 | 1.7 | -1.7 | 1.7 | -2.0 | -2.1 | -2.2 | -0.9 | 1.8 | -2.1 |
| Pavlov. Cond. magazine entry latency | 2.2 | 2.8 | 4.3 | -1.8 | -1.3 | 2.0 | -2.0 | 2.1 | -1.1 | -1.7 | -1.7 | 0.2 | 2.0 | -1.8 |
| Latency to leave start box in cocaine runway, M | 2.2 | 2.1 | 3.7 | -1.3 | -0.6 | 1.9 | -1.9 | 1.9 | -0.1 | -1.1 | -1.0 | 1.4 | 1.9 | -1.6 |
| Conditioned locomotion | 2.1 | 2.5 | 4.2 | 1.8 | 1.9 | -1.0 | 0.9 | -0.9 | 2.1 | 1.8 | 1.8 | 1.7 | -0.9 | 1.6 |
| Intermittent access standard deviation | 2.1 | 2.3 | 3.9 | -1.7 | -0.9 | 2.0 | -1.8 | 1.7 | -0.5 | -1.3 | -1.5 | 0.5 | 1.9 | -1.8 |
| Incentive salience index mean | 2.1 | 2.6 | 3.4 | -1.8 | -1.8 | 1.4 | -1.4 | 1.5 | -1.8 | -1.8 | -1.8 | -1.0 | 1.4 | -1.7 |
| Time in novel zone, NPP test | 2.1 | 2.2 | 4.6 | 1.3 | 0.6 | -1.9 | 2.0 | -2.0 | 0.1 | 1.1 | 1.1 | -1.2 | -2.1 | 1.5 |
| Bone: stiffness | 2.1 | 3.3 | 5.5 | 1.8 | 1.3 | -2.3 | 2.3 | -2.3 | 1.0 | 1.7 | 1.7 | -0.4 | -2.2 | 1.8 |
| Delay discount hyperbolic model param | 2.1 | 2.2 | 3.6 | -1.5 | -1.0 | 1.9 | -1.8 | 1.7 | -1.0 | -1.4 | -1.5 | 0.2 | 1.8 | -1.5 |
| Fecal boli incidents, locomotor time 1 | 2.1 | 2.2 | 3.4 | 1.7 | 1.8 | -1.2 | 1.2 | -1.7 | 1.2 | 1.7 | 1.7 | 0.6 | -1.4 | 1.8 |
| Light reinforcement 2 | 2.0 | 2.6 | 3.4 | -1.7 | -1.7 | 1.6 | -1.6 | 1.5 | -1.5 | -1.8 | -1.8 | -0.9 | 1.7 | -1.7 |
| Conditioned reinforcement - actives | 2.0 | 2.0 | 2.8 | -1.6 | -1.3 | 1.5 | -1.6 | 1.3 | -1.1 | -1.5 | -1.7 | -0.2 | 1.3 | -1.7 |
| Bone: trabecular spacing | 2.0 | 2.6 | 7.4 | 1.5 | 2.2 | -0.1 | 0.1 | -0.1 | 2.6 | 1.7 | 1.7 | 2.7 | -0.0 | 1.1 |
| Delay discounting water rate 24 sec | 1.9 | 2.7 | 8.1 | 1.3 | 2.3 | 0.0 | -0.0 | 0.1 | 2.8 | 1.7 | 1.7 | 2.8 | -0.2 | 0.9 |
| Condit. Reinf. active responses | 1.9 | 2.6 | 3.9 | -1.8 | -1.4 | 1.9 | -1.8 | 1.8 | -0.7 | -1.7 | -1.7 | 0.2 | 1.8 | -2.0 |
| Novelty place preference | 1.9 | 2.0 | 4.2 | 1.1 | 0.4 | -1.8 | 1.9 | -1.9 | -0.1 | 0.9 | 1.0 | -1.4 | -2.1 | 1.4 |
| Bone: trabecular tissue density | 1.9 | 2.6 | 3.9 | 1.9 | 1.9 | -1.4 | 1.4 | -1.3 | 1.5 | 1.9 | 1.9 | 1.2 | -1.3 | 2.0 |
| Length with tail | 1.8 | 6.7 | 8.7 | -2.9 | -2.7 | 2.5 | -2.6 | 2.4 | -2.2 | -2.9 | -2.9 | -1.1 | 2.6 | -2.9 |
| Condit. Reinf. lever presses | 1.8 | 2.4 | 4.2 | -1.5 | -1.0 | 2.0 | -2.0 | 1.9 | -0.4 | -1.4 | -1.4 | 0.7 | 2.0 | -1.8 |
| Delay discounting water rate 12 sec | 1.7 | 2.6 | 6.0 | 1.7 | 2.1 | -0.8 | 0.8 | -0.8 | 2.4 | 1.8 | 1.9 | 2.1 | -0.8 | 1.3 |
| Condit. Reinf. active minus inactive responses | 1.7 | 2.2 | 3.7 | -1.4 | -0.8 | 1.9 | -1.9 | 1.9 | -0.2 | -1.3 | -1.3 | 1.0 | 1.9 | -1.6 |
| Time in familiar zone, hab. session 1 | 1.7 | 1.6 | 2.8 | -1.3 | -0.9 | 1.5 | -1.6 | 1.7 | -0.3 | -1.2 | -1.2 | 0.6 | 1.6 | -1.5 |
| Locomotion velocity, hab. session 2 | 1.7 | 2.2 | 6.6 | -1.4 | -1.8 | 0.6 | -0.6 | 0.7 | -2.6 | -1.6 | -1.5 | -2.3 | 0.7 | -0.9 |
| Delay discounting water rate 18 sec | 1.6 | 2.1 | 9.7 | 0.5 | 1.6 | 0.8 | -0.8 | 1.0 | 2.4 | 1.0 | 0.9 | 3.1 | 0.9 | 0.0 |
| Delta ambulatory time before/after self-admin | 1.6 | 1.8 | 2.4 | -1.5 | -1.4 | 1.4 | -1.4 | 1.4 | -1.1 | -1.5 | -1.3 | -0.5 | 1.4 | -1.5 |
| Total heroin consumption | 1.6 | 1.9 | 2.7 | -1.5 | -1.3 | 1.6 | -1.4 | 1.5 | -1.1 | -1.4 | -1.6 | -0.1 | 1.5 | -1.6 |
| Area under the delay curve | 1.6 | 1.7 | 2.8 | 1.3 | 0.9 | -1.7 | 1.6 | -1.5 | 0.8 | 1.2 | 1.3 | -0.2 | -1.6 | 1.3 |
| Latency to leave start box in cocaine runway | 1.6 | 1.7 | 3.7 | -1.6 | -1.7 | 0.7 | -0.6 | 0.5 | -1.9 | -1.5 | -1.6 | -1.2 | 0.7 | -1.4 |
| Liver weight, right | 1.5 | 2.5 | 3.5 | 1.7 | 1.5 | -1.8 | 1.7 | -1.8 | 0.9 | 1.7 | 1.7 | -0.0 | -1.8 | 1.9 |
| Pavlov. Cond. response bias | 1.5 | 2.1 | 3.3 | -1.5 | -1.2 | 1.7 | -1.7 | 1.6 | -0.4 | -1.5 | -1.4 | 0.2 | 1.7 | -1.8 |
| Intermittent access day 15 total infusions | 1.5 | 1.7 | 3.0 | -1.3 | -0.8 | 1.7 | -1.6 | 1.6 | -0.4 | -1.2 | -1.3 | 0.5 | 1.7 | -1.5 |
| Locomotion velocity, session 8 | 1.5 | 1.8 | 4.9 | -1.3 | -1.8 | 0.3 | -0.3 | 0.4 | -2.1 | -1.4 | -1.4 | -2.2 | 0.3 | -0.9 |
| Condit. Reinf. active-inactive response ratio | 1.5 | 1.7 | 2.9 | -1.3 | -0.8 | 1.7 | -1.6 | 1.7 | -0.3 | -1.1 | -1.2 | 0.4 | 1.6 | -1.5 |
| Delta distance traveled before/after self-admin | 1.5 | 1.6 | 2.1 | -1.3 | -1.2 | 1.4 | -1.4 | 1.3 | -0.9 | -1.4 | -1.2 | -0.2 | 1.4 | -1.4 |
| Delay discount exponential model param | 1.5 | 1.5 | 2.5 | -1.3 | -0.9 | 1.6 | -1.5 | 1.4 | -0.9 | -1.2 | -1.3 | 0.1 | 1.5 | -1.3 |
| Zn content in liver | 1.5 | 1.7 | 3.8 | -0.8 | 0.2 | 1.8 | -1.8 | 1.8 | 0.7 | -0.4 | -0.5 | 1.9 | 1.6 | -1.1 |
| Total zone transitions, hab. session 1 | 1.4 | 2.0 | 4.9 | -1.5 | -1.8 | 0.8 | -0.7 | 0.8 | -2.2 | -1.6 | -1.6 | -1.9 | 0.7 | -1.1 |
| Total locomotion distance, hab. session 2 | 1.4 | 1.8 | 4.9 | -1.3 | -1.6 | 0.7 | -0.7 | 0.8 | -2.2 | -1.5 | -1.4 | -1.9 | 0.8 | -0.9 |
| Diff in mean of infusions in LGA sessions | 1.4 | 1.6 | 2.3 | -1.3 | -1.1 | 1.4 | -1.4 | 1.5 | -0.9 | -1.3 | -1.1 | -0.0 | 1.4 | -1.4 |
| Delta time to tail flick, vehicle, before/after SA | 1.4 | 1.4 | 4.2 | 1.2 | 1.5 | -0.3 | 0.2 | -0.2 | 1.9 | 1.2 | 1.2 | 2.0 | -0.2 | 0.9 |
| Right kidney weight | 1.3 | 3.6 | 4.5 | -2.1 | -1.9 | 2.0 | -2.0 | 1.8 | -1.6 | -2.1 | -2.1 | -0.7 | 2.0 | -2.1 |
| Condit. Reinf. inactive responses | 1.3 | 1.6 | 2.7 | -1.5 | -1.4 | 1.1 | -1.1 | 1.1 | -0.8 | -1.5 | -1.5 | -0.7 | 1.1 | -1.6 |
| Condit. Reinf. lever reinforcers received | 1.3 | 1.9 | 2.8 | -1.4 | -1.0 | 1.7 | -1.7 | 1.7 | -0.2 | -1.3 | -1.3 | 0.5 | 1.7 | -1.7 |
| Short access day 1 locomotion | 1.3 | 1.4 | 2.2 | -1.3 | -1.4 | 0.9 | -0.9 | 0.8 | -1.2 | -1.4 | -1.5 | -1.0 | 0.9 | -1.3 |
| Degree of sensitization stereotypy | 1.3 | 1.4 | 3.1 | 1.0 | 0.4 | -1.6 | 1.6 | -1.6 | 0.1 | 0.9 | 0.9 | -1.0 | -1.8 | 1.1 |
| Condit. Reinf. inactive responses | 1.3 | 1.5 | 4.2 | -1.3 | -1.6 | 0.7 | -0.6 | 0.7 | -2.0 | -1.4 | -1.4 | -1.4 | 0.7 | -0.9 |
| Bone: tissue strength | 1.3 | 1.2 | 1.8 | 1.1 | 0.9 | -1.4 | 1.3 | -1.4 | 0.5 | 1.1 | 1.1 | -0.2 | -1.3 | 1.2 |
| Bone: trabecular number | 1.3 | 2.0 | 3.7 | -1.5 | -1.9 | 0.6 | -0.6 | 0.6 | -1.9 | -1.6 | -1.6 | -1.9 | 0.6 | -1.3 |
| Run reversals in cocaine runway, males | 1.3 | 1.3 | 1.9 | -1.2 | -1.3 | 1.0 | -1.0 | 1.2 | -1.1 | -1.3 | -1.4 | -0.6 | 1.0 | -1.2 |
| Glucose | 1.2 | 1.8 | 2.3 | 1.4 | 1.3 | -1.4 | 1.5 | -1.4 | 1.1 | 1.5 | 1.5 | 0.5 | -1.4 | 1.4 |
| Std. dev. time between licks in bursts | 1.2 | 1.4 | 2.4 | -1.4 | -1.5 | 0.8 | -0.7 | 0.8 | -1.2 | -1.4 | -1.4 | -1.1 | 0.9 | -1.4 |
| Bone: maximum diameter | 1.2 | 2.1 | 3.7 | -1.7 | -1.9 | 0.8 | -0.8 | 0.8 | -1.8 | -1.7 | -1.7 | -1.6 | 0.8 | -1.6 |
| Vertical activity count, locomotor time 2 | 1.2 | 1.3 | 2.5 | 1.2 | 1.5 | -0.6 | 0.7 | -0.7 | 1.6 | 1.4 | 1.2 | 1.3 | -0.6 | 1.1 |
| Delay discounting time to switch 0 sec | 1.1 | 1.7 | 3.1 | 1.1 | 0.3 | -1.7 | 1.7 | -1.8 | -0.6 | 0.8 | 0.8 | -1.5 | -1.6 | 1.5 |
| Reaction time number correct | 1.1 | 1.5 | 4.2 | 1.3 | 1.5 | -0.6 | 0.6 | -0.4 | 2.0 | 1.3 | 1.3 | 1.7 | -0.7 | 1.0 |
| Reaction time trials correct on left | 1.1 | 1.5 | 4.2 | 1.3 | 1.5 | -0.6 | 0.6 | -0.4 | 2.0 | 1.3 | 1.3 | 1.7 | -0.7 | 1.0 |
| Reaction time trials AUC | 1.1 | 1.6 | 4.6 | 1.3 | 1.6 | -0.5 | 0.5 | -0.4 | 2.2 | 1.3 | 1.3 | 1.9 | -0.6 | 0.9 |
| Locomotion velocity, session 1 | 1.1 | 1.2 | 3.0 | -1.1 | -1.4 | 0.5 | -0.4 | 0.5 | -1.6 | -1.2 | -1.2 | -1.7 | 0.5 | -0.9 |
| Delay disc. indifference point, 8s delay | 1.1 | 1.1 | 1.6 | 1.2 | 1.1 | -1.0 | 1.0 | -0.9 | 1.2 | 1.2 | 1.3 | 0.5 | -0.8 | 1.1 |
| Time >=10cm from walls, locomotor time 2 | 1.1 | 1.2 | 1.6 | 1.2 | 1.2 | -1.0 | 1.0 | -1.2 | 1.1 | 1.2 | 1.3 | 0.6 | -1.0 | 1.2 |
| Body weight | 1.0 | 4.3 | 5.3 | 2.3 | 2.0 | -2.2 | 2.1 | -2.3 | 1.8 | 2.3 | 2.3 | 0.6 | -2.2 | 2.2 |
| Tibialis anterior weight | 1.0 | 3.4 | 4.9 | 1.9 | 1.7 | -2.0 | 2.1 | -2.1 | 1.5 | 2.0 | 2.0 | 0.4 | -2.2 | 1.9 |
| Reaction time trials on left | 1.0 | 1.4 | 3.8 | 1.3 | 1.5 | -0.6 | 0.6 | -0.5 | 2.0 | 1.3 | 1.3 | 1.6 | -0.7 | 0.9 |
| Reaction time trials completed | 1.0 | 1.4 | 3.8 | 1.3 | 1.5 | -0.6 | 0.6 | -0.5 | 2.0 | 1.3 | 1.3 | 1.6 | -0.7 | 0.9 |
| Cocaine induced anxiety | 1.0 | 1.1 | 2.8 | -1.1 | -1.3 | 0.6 | -0.7 | 0.4 | -1.7 | -1.2 | -1.2 | -1.2 | 0.7 | -0.9 |
| Locomotion distance, session 1 | 1.0 | 1.3 | 5.0 | -0.8 | -1.3 | -0.1 | 0.2 | -0.1 | -2.1 | -1.0 | -0.9 | -2.2 | -0.2 | -0.3 |
| Latency to leave start box in cocaine runway, F | 1.0 | 1.1 | 4.0 | -0.8 | -1.2 | -0.4 | 0.5 | -0.7 | -1.8 | -0.7 | -1.0 | -2.0 | -0.4 | -0.4 |
| Delay discounting total patch changes 18 sec | 0.9 | 1.2 | 1.6 | -1.1 | -0.9 | 1.2 | -1.3 | 1.3 | -0.8 | -1.1 | -1.1 | 0.1 | 1.2 | -1.2 |
| Reaction time premature initiation rate | 0.9 | 1.2 | 2.2 | -1.0 | -0.5 | 1.4 | -1.4 | 1.4 | -0.1 | -0.8 | -0.8 | 0.8 | 1.5 | -1.1 |
| Pavlov. Cond. index score | 0.9 | 1.1 | 1.9 | -1.2 | -1.0 | 1.1 | -1.2 | 1.0 | -0.5 | -1.2 | -1.1 | -0.2 | 1.2 | -1.4 |
| Pavlov. Cond. latency score | 0.9 | 1.1 | 1.9 | -1.2 | -1.1 | 1.0 | -1.1 | 0.9 | -0.6 | -1.2 | -1.2 | -0.5 | 1.1 | -1.4 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.9 | 1.2 | 2.0 | -1.2 | -1.1 | 1.1 | -1.1 | 1.0 | -0.6 | -1.3 | -1.2 | -0.4 | 1.2 | -1.4 |
| Intermittent access terminal intake (last 3 days) | 0.9 | 1.0 | 1.6 | -1.1 | -0.8 | 1.2 | -1.1 | 1.0 | -0.5 | -1.0 | -1.1 | 0.1 | 1.3 | -1.2 |
| Short access total locomotion | 0.9 | 0.9 | 1.5 | -1.2 | -1.0 | 0.9 | -1.0 | 0.8 | -0.8 | -1.1 | -1.2 | -0.4 | 0.8 | -1.1 |
| Compulsive drug intake | 0.9 | 0.9 | 2.0 | 0.8 | 0.5 | -1.3 | 1.2 | -1.3 | 0.1 | 0.8 | 0.7 | -0.5 | -1.4 | 1.0 |
| Time in novel zone, hab. session 1 | 0.9 | 0.8 | 1.7 | 0.5 | 0.0 | -1.2 | 1.2 | -1.3 | -0.3 | 0.4 | 0.4 | -1.3 | -1.3 | 0.7 |
| Total zone transitions, hab. session 2 | 0.9 | 1.2 | 5.8 | -0.1 | -0.8 | -0.8 | 0.8 | -0.7 | -1.9 | -0.4 | -0.3 | -2.4 | -0.7 | 0.5 |
| Pavlov. Cond. response bias | 0.9 | 1.0 | 1.5 | -1.1 | -0.9 | 1.1 | -1.1 | 1.2 | -0.9 | -1.1 | -1.1 | -0.2 | 1.0 | -1.1 |
| Bone: apparent density | 0.9 | 1.6 | 5.6 | -0.9 | -1.6 | -0.7 | 0.7 | -0.6 | -2.0 | -1.1 | -1.1 | -2.4 | -0.6 | -0.5 |
| Time to tail flick, vehicle, before self-admin | 0.9 | 0.9 | 1.9 | -1.0 | -1.2 | 0.4 | -0.3 | 0.5 | -1.4 | -1.0 | -1.1 | -1.4 | 0.4 | -0.8 |
| Distance moved, locomotor task time 2 | 0.9 | 1.0 | 1.5 | 1.1 | 1.2 | -0.8 | 0.8 | -0.8 | 1.1 | 1.2 | 1.1 | 0.8 | -0.8 | 1.1 |
| Tibia length | 0.8 | 2.2 | 3.4 | -1.5 | -1.2 | 1.7 | -1.7 | 1.7 | -0.9 | -1.5 | -1.5 | 0.0 | 1.9 | -1.6 |
| Pavlov. Cond. lever latency | 0.8 | 1.1 | 1.9 | 1.2 | 1.1 | -1.1 | 1.1 | -1.0 | 0.5 | 1.2 | 1.2 | 0.4 | -1.1 | 1.4 |
| Pavlov. Cond. magazine entry number | 0.8 | 1.0 | 1.9 | 1.2 | 1.1 | -0.9 | 0.9 | -0.9 | 0.6 | 1.1 | 1.1 | 0.5 | -1.0 | 1.4 |
| Intermittent access total locomotion | 0.8 | 0.9 | 1.4 | -1.2 | -0.8 | 1.0 | -0.9 | 0.9 | -0.8 | -1.0 | -1.2 | -0.2 | 1.0 | -1.1 |
| Post-drug Anxiety | 0.8 | 0.9 | 2.2 | -0.9 | -1.2 | 0.4 | -0.6 | 0.5 | -1.5 | -1.0 | -1.0 | -1.4 | 0.7 | -0.7 |
| Locomotion velocity, session 7 | 0.8 | 0.9 | 1.6 | -1.1 | -1.1 | 0.8 | -0.8 | 0.7 | -0.4 | -1.1 | -1.1 | -0.6 | 0.9 | -1.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.8 | 1.0 | 1.5 | -1.1 | -1.2 | 0.8 | -0.8 | 0.9 | -1.2 | -1.1 | -1.1 | -0.7 | 0.7 | -1.0 |
| Bone: cortical porosity | 0.8 | 0.9 | 1.6 | -1.0 | -1.2 | 0.6 | -0.6 | 0.6 | -1.3 | -1.1 | -1.1 | -0.9 | 0.5 | -0.9 |
| Bone: final force | 0.8 | 1.2 | 2.6 | 0.9 | 0.3 | -1.6 | 1.6 | -1.5 | 0.2 | 0.8 | 0.8 | -1.0 | -1.5 | 0.9 |
| Delta time in open arm before/after self-admin | 0.8 | 0.8 | 1.3 | 0.9 | 0.6 | -1.1 | 1.1 | -1.1 | 0.3 | 0.8 | 0.9 | -0.6 | -1.0 | 1.0 |
| Extinction: sum of active levers before priming | 0.8 | 0.9 | 1.8 | -0.7 | -0.0 | 1.3 | -1.3 | 1.1 | 0.1 | -0.4 | -0.7 | 1.2 | 1.1 | -0.9 |
| Time in closed arm before self-admin | 0.8 | 0.9 | 2.3 | 0.5 | -0.2 | -1.2 | 1.2 | -1.1 | -0.7 | 0.3 | 0.3 | -1.5 | -1.2 | 0.8 |
| Bouts of movement, locomotor time 2 | 0.8 | 0.8 | 2.0 | -0.9 | -1.2 | 0.3 | -0.3 | 0.7 | -1.4 | -1.0 | -1.0 | -1.4 | 0.4 | -0.7 |
| Total resting periods, locomotor time 2 | 0.8 | 0.8 | 2.1 | -0.9 | -1.2 | 0.3 | -0.3 | 0.7 | -1.4 | -1.0 | -0.9 | -1.4 | 0.4 | -0.7 |
| Na content in liver | 0.8 | 0.9 | 1.6 | 0.6 | 0.2 | -1.2 | 1.3 | -1.2 | -0.4 | 0.6 | 0.5 | -1.1 | -1.2 | 0.9 |
| Delay discounting water rate 6 sec | 0.7 | 0.9 | 3.8 | -0.1 | 0.6 | 1.0 | -1.0 | 1.0 | 1.3 | 0.1 | 0.1 | 2.0 | 1.0 | -0.5 |
| Reaction time premature initiations | 0.7 | 1.0 | 3.0 | -0.4 | 0.3 | 1.2 | -1.2 | 1.3 | 1.0 | -0.2 | -0.2 | 1.7 | 1.2 | -0.7 |
| Social response proportion | 0.7 | 0.8 | 1.6 | -0.9 | -1.0 | 0.7 | -0.7 | 0.7 | -1.3 | -1.0 | -1.0 | -1.0 | 0.8 | -0.6 |
| Pavlov. Cond. change in total contacts | 0.7 | 0.9 | 1.5 | -1.1 | -0.9 | 1.1 | -1.1 | 1.1 | -0.4 | -1.0 | -1.0 | -0.0 | 1.1 | -1.2 |
| Conditioned reinforcement - inactives | 0.7 | 0.7 | 1.3 | 0.9 | 1.1 | -0.7 | 0.6 | -0.7 | 1.1 | 1.0 | 0.9 | 0.7 | -0.7 | 0.9 |
| Stereotopy head waving duration, day 7 | 0.7 | 0.9 | 2.3 | -1.0 | -1.3 | 0.1 | -0.1 | 0.2 | -1.5 | -1.0 | -1.0 | -1.5 | 0.1 | -0.7 |
| Condit. Reinf. lever presses | 0.7 | 1.0 | 3.7 | -0.6 | -1.2 | -0.3 | 0.4 | -0.3 | -1.9 | -0.7 | -0.8 | -1.8 | -0.4 | -0.3 |
| Pavlov. Cond. latency score | 0.7 | 0.8 | 2.1 | -1.0 | -1.2 | 0.4 | -0.4 | 0.5 | -1.4 | -1.0 | -1.1 | -1.1 | 0.3 | -0.8 |
| Bone: cortical apparent density | 0.7 | 0.9 | 1.2 | 1.0 | 0.9 | -1.0 | 1.0 | -1.0 | 0.7 | 1.0 | 1.0 | 0.3 | -1.1 | 1.0 |
| Bone: cortical thickness | 0.7 | 1.2 | 2.3 | 1.0 | 0.6 | -1.5 | 1.4 | -1.5 | 0.3 | 0.9 | 0.9 | -0.6 | -1.4 | 1.1 |
| Bone: maximum force | 0.7 | 1.3 | 2.6 | 1.0 | 0.5 | -1.6 | 1.6 | -1.5 | 0.5 | 0.9 | 0.9 | -0.7 | -1.5 | 1.0 |
| Distance traveled after self-admin | 0.7 | 0.8 | 1.3 | -1.2 | -0.9 | 0.9 | -0.8 | 0.6 | -1.0 | -0.9 | -0.9 | -0.5 | 0.7 | -1.0 |
| Time in open arm before self-admin | 0.7 | 0.7 | 1.2 | -1.0 | -0.6 | 1.0 | -1.0 | 0.9 | -0.3 | -0.8 | -0.8 | 0.6 | 0.9 | -1.1 |
| Delay disc. indifference point, 4s delay | 0.7 | 0.7 | 1.7 | 0.7 | 0.1 | -1.3 | 1.2 | -1.0 | 0.2 | 0.5 | 0.7 | -0.6 | -1.2 | 0.7 |
| Change in fecal boli incidents, locomotor task | 0.7 | 0.7 | 1.5 | -0.9 | -1.2 | 0.3 | -0.3 | 0.1 | -0.8 | -0.9 | -1.1 | -0.9 | 0.3 | -1.0 |
| Rest time, locomotor task time 2 | 0.7 | 0.8 | 1.3 | -1.0 | -1.2 | 0.6 | -0.7 | 0.7 | -1.1 | -1.1 | -0.9 | -0.8 | 0.7 | -0.9 |
| Weight adjusted by age | 0.7 | 0.8 | 2.2 | 1.0 | 1.2 | -0.3 | 0.3 | -0.4 | 1.5 | 0.9 | 0.9 | 1.4 | -0.3 | 0.7 |
| Locomotion in novel chamber post-restriction | 0.7 | 0.8 | 1.3 | -0.9 | -0.8 | 1.0 | -1.0 | 1.2 | -0.2 | -1.0 | -1.0 | 0.5 | 1.0 | -1.1 |
| Intraocular pressure | 0.6 | 0.9 | 3.6 | 0.6 | 1.2 | 0.5 | -0.5 | 0.5 | 1.6 | 0.7 | 0.7 | 1.9 | 0.5 | 0.2 |
| Indifference point AUC | 0.6 | 0.7 | 1.3 | -0.9 | -0.5 | 1.1 | -1.1 | 1.0 | -0.5 | -0.7 | -0.8 | 0.2 | 1.0 | -0.9 |
| Delay discounting total patch changes 12 sec | 0.6 | 0.8 | 1.7 | 1.0 | 1.3 | -0.3 | 0.4 | -0.4 | 1.1 | 1.1 | 1.1 | 1.2 | -0.4 | 0.9 |
| Reaction time mean minus median | 0.6 | 0.8 | 1.5 | -1.0 | -0.7 | 1.0 | -1.0 | 1.0 | -0.3 | -0.8 | -0.8 | -0.1 | 1.2 | -1.2 |
| Social time | 0.6 | 0.7 | 1.4 | 1.1 | 0.9 | -0.8 | 0.8 | -0.9 | 0.3 | 1.0 | 1.0 | 0.2 | -0.7 | 1.2 |
| Pavlov. Cond. lever contacts | 0.6 | 0.9 | 1.5 | -1.0 | -0.7 | 1.1 | -1.2 | 1.0 | -0.1 | -1.0 | -0.9 | 0.1 | 1.1 | -1.2 |
| Bone: final moment | 0.6 | 1.0 | 2.1 | 0.7 | 0.2 | -1.4 | 1.4 | -1.4 | 0.1 | 0.6 | 0.6 | -0.9 | -1.4 | 0.8 |
| Bone: maximum moment | 0.6 | 1.0 | 2.1 | 0.9 | 0.4 | -1.5 | 1.4 | -1.4 | 0.4 | 0.8 | 0.8 | -0.8 | -1.3 | 0.8 |
| Time in open arm after self-admin | 0.6 | 0.6 | 0.8 | 0.8 | 0.8 | -0.8 | 0.9 | -0.8 | 0.7 | 0.9 | 0.9 | 0.2 | -0.8 | 0.8 |
| Time to tail flick, test, before self-admin | 0.6 | 0.6 | 1.6 | -0.6 | -1.1 | 0.0 | -0.2 | 0.2 | -1.2 | -0.8 | -0.9 | -1.3 | 0.2 | -0.5 |
| Delay disc. indifference point, 24s delay | 0.6 | 0.6 | 1.0 | 0.8 | 0.7 | -0.7 | 0.7 | -0.9 | 0.8 | 0.7 | 1.0 | 0.6 | -0.9 | 0.7 |
| Number of licking bursts | 0.5 | 0.5 | 2.5 | 0.5 | 0.9 | 0.2 | -0.1 | 0.2 | 1.1 | 0.6 | 0.6 | 1.6 | 0.1 | 0.3 |
| Food consumed during 24 hour testing period | 0.5 | 0.6 | 0.9 | 0.8 | 0.7 | -0.8 | 0.9 | -0.7 | 0.8 | 0.8 | 0.8 | 0.4 | -1.0 | 0.7 |
| Delay discounting water rate 0 sec | 0.5 | 0.7 | 3.2 | 0.2 | 0.9 | 0.5 | -0.4 | 0.5 | 1.6 | 0.6 | 0.5 | 1.8 | 0.3 | -0.2 |
| Cocaine response before conditioning | 0.5 | 0.6 | 0.9 | -0.8 | -0.9 | 0.6 | -0.7 | 0.6 | -0.7 | -1.0 | -0.9 | -0.7 | 0.7 | -0.9 |
| Condit. Reinf. active-inactive response ratio | 0.5 | 0.6 | 2.7 | 0.2 | 0.8 | 0.6 | -0.6 | 0.7 | 0.9 | 0.4 | 0.4 | 1.6 | 0.6 | 0.1 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.6 | 1.2 | -0.9 | -0.8 | 0.7 | -0.7 | 0.6 | -0.5 | -0.9 | -0.8 | -0.4 | 0.7 | -1.1 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.6 | 1.2 | 0.9 | 1.0 | -0.4 | 0.4 | -0.4 | 1.1 | 0.9 | 0.9 | 0.9 | -0.4 | 0.8 |
| Intermitt. access escalation Index | 0.5 | 0.4 | 1.3 | 0.0 | -0.6 | -0.7 | 0.7 | -0.8 | -0.7 | -0.3 | -0.1 | -1.2 | -0.8 | 0.2 |
| Total locomotion distance, NPP test | 0.5 | 0.6 | 3.5 | -0.2 | -0.7 | -0.5 | 0.5 | -0.4 | -1.4 | -0.3 | -0.3 | -1.9 | -0.4 | 0.2 |
| Locomotion velocity, NPP test | 0.5 | 0.7 | 3.5 | -0.5 | -0.9 | -0.2 | 0.2 | -0.1 | -1.6 | -0.6 | -0.6 | -1.9 | -0.1 | -0.0 |
| Pavlov. Cond. index score | 0.5 | 0.6 | 1.3 | -0.9 | -1.0 | 0.5 | -0.5 | 0.6 | -1.1 | -0.9 | -0.9 | -0.7 | 0.4 | -0.7 |
| Pavlov. Cond. lever contacts | 0.5 | 0.6 | 2.0 | -0.6 | -1.1 | -0.2 | 0.2 | -0.1 | -1.4 | -0.7 | -0.7 | -1.4 | -0.3 | -0.3 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.0 | 0.9 | 0.7 | -0.9 | 0.9 | -1.0 | 0.6 | 0.8 | 0.8 | -0.0 | -0.9 | 0.8 |
| Bone: connectivity density | 0.5 | 0.9 | 3.2 | -0.2 | -0.9 | -1.0 | 1.0 | -0.8 | -1.2 | -0.4 | -0.4 | -1.8 | -0.9 | 0.1 |
| Bone: cortical porosity | 0.5 | 0.6 | 2.1 | -0.6 | -1.0 | -0.1 | 0.1 | -0.1 | -1.3 | -0.7 | -0.7 | -1.5 | -0.2 | -0.3 |
| Bone: cortical tissue density | 0.5 | 0.6 | 0.8 | 0.8 | 0.7 | -0.8 | 0.8 | -0.8 | 0.6 | 0.8 | 0.8 | 0.3 | -0.9 | 0.9 |
| Bone: endosteal perimeter | 0.5 | 1.0 | 1.8 | -1.1 | -1.4 | 0.4 | -0.4 | 0.5 | -1.2 | -1.2 | -1.2 | -1.1 | 0.5 | -1.1 |
| Bone: periosteal perimeter | 0.5 | 0.8 | 2.0 | -0.9 | -1.3 | -0.0 | 0.0 | 0.1 | -1.2 | -1.0 | -1.0 | -1.4 | 0.0 | -0.8 |
| Bone: post-yield work | 0.5 | 0.6 | 0.8 | 0.9 | 0.8 | -0.8 | 0.8 | -0.7 | 0.9 | 0.9 | 0.9 | 0.2 | -0.8 | 0.7 |
| Time to tail flick, vehicle, after self-admin | 0.5 | 0.5 | 2.2 | 0.3 | 0.6 | 0.5 | -0.6 | 0.7 | 1.0 | 0.2 | 0.3 | 1.5 | 0.7 | -0.0 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 1.4 | 0.2 | -0.3 | -0.7 | 0.7 | -1.2 | -0.7 | -0.0 | 0.1 | -1.1 | -0.8 | 0.5 |
| Progressive ratio | 0.5 | 0.5 | 1.2 | 0.9 | 1.1 | -0.4 | 0.4 | -0.3 | 0.7 | 0.9 | 0.9 | 0.5 | -0.3 | 0.9 |
| Rb content in liver | 0.5 | 0.6 | 2.2 | 0.1 | -0.4 | -0.9 | 0.9 | -0.9 | -0.8 | -0.0 | 0.0 | -1.5 | -1.0 | 0.4 |
| Length without tail | 0.4 | 0.8 | 2.7 | -0.8 | -1.2 | -0.0 | -0.0 | 0.0 | -1.4 | -0.9 | -1.0 | -1.6 | 0.0 | -0.6 |
| Times rat made contact with spout | 0.4 | 0.5 | 1.2 | 0.7 | 0.9 | -0.3 | 0.3 | -0.3 | 1.1 | 0.8 | 0.8 | 1.1 | -0.3 | 0.6 |
| Water consumed over 24 hours | 0.4 | 0.5 | 1.2 | 0.4 | -0.1 | -1.0 | 1.0 | -1.0 | -0.2 | 0.3 | 0.3 | -1.0 | -1.1 | 0.5 |
| Reaction time num false alarms AUC | 0.4 | 0.6 | 2.3 | 0.6 | 0.9 | -0.1 | 0.2 | -0.1 | 1.5 | 0.7 | 0.7 | 1.5 | -0.2 | 0.3 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.4 | 1.0 | -0.6 | -0.3 | 0.9 | -0.8 | 0.8 | -0.1 | -0.5 | -0.5 | 0.3 | 1.0 | -0.6 |
| Short access day 1 total infusions | 0.4 | 0.4 | 0.9 | -0.6 | -0.8 | 0.2 | -0.3 | 0.1 | -0.9 | -0.7 | -0.8 | -0.9 | 0.2 | -0.4 |
| Stereotopy head waving bouts, day 7 | 0.4 | 0.4 | 1.7 | -0.5 | -0.9 | -0.3 | 0.3 | -0.2 | -1.1 | -0.5 | -0.5 | -1.3 | -0.3 | -0.3 |
| Bone: cortical area | 0.4 | 0.6 | 1.5 | 0.3 | -0.3 | -1.1 | 1.1 | -1.1 | -0.4 | 0.1 | 0.1 | -1.2 | -1.1 | 0.3 |
| Ambulatory time after self-admin | 0.4 | 0.4 | 0.8 | -0.9 | -0.7 | 0.7 | -0.6 | 0.4 | -0.8 | -0.6 | -0.7 | -0.5 | 0.4 | -0.7 |
| Distance moved, locomotor task time 1 | 0.4 | 0.4 | 1.2 | 0.2 | -0.3 | -0.9 | 0.8 | -1.1 | -0.5 | -0.1 | 0.2 | -1.0 | -0.8 | 0.4 |
| Run reversals in cocaine runway, females | 0.4 | 0.4 | 0.7 | -0.8 | -0.8 | 0.5 | -0.5 | 0.6 | -0.7 | -0.7 | -0.8 | -0.4 | 0.5 | -0.8 |
| Co content in liver | 0.4 | 0.5 | 0.9 | -0.7 | -0.4 | 0.9 | -0.9 | 0.9 | -0.3 | -0.6 | -0.6 | 0.2 | 0.9 | -0.8 |
| Cu content in liver | 0.4 | 0.4 | 2.4 | -0.2 | -0.5 | -0.5 | 0.6 | -0.6 | -0.9 | -0.2 | -0.2 | -1.6 | -0.5 | 0.0 |
| K content in liver | 0.4 | 0.4 | 1.5 | -0.4 | -0.7 | -0.3 | 0.3 | -0.3 | -1.2 | -0.4 | -0.4 | -1.2 | -0.3 | -0.1 |
| Mg content in liver | 0.4 | 0.4 | 1.8 | -0.5 | -0.8 | -0.3 | 0.4 | -0.4 | -1.2 | -0.4 | -0.5 | -1.4 | -0.3 | -0.2 |
| Heart weight | 0.3 | 0.4 | 0.9 | -0.3 | 0.1 | 0.8 | -0.8 | 0.8 | 0.4 | -0.2 | -0.2 | 0.8 | 0.9 | -0.5 |
| Parametrial fat weight | 0.3 | 0.6 | 1.1 | -0.8 | -0.5 | 1.0 | -1.0 | 0.8 | -0.2 | -0.8 | -0.8 | 0.3 | 1.0 | -1.1 |
| Retroperitoneal fat weight | 0.3 | 1.0 | 1.5 | 1.2 | 1.2 | -1.0 | 0.9 | -0.8 | 1.0 | 1.2 | 1.2 | 0.4 | -0.8 | 1.1 |
| Reaction time mean minus median AUC | 0.3 | 0.4 | 1.8 | -0.5 | -0.8 | -0.2 | 0.2 | -0.1 | -0.9 | -0.5 | -0.5 | -1.3 | -0.0 | -0.5 |
| Reaction time omissions | 0.3 | 0.4 | 0.7 | -0.8 | -0.7 | 0.5 | -0.5 | 0.4 | -0.8 | -0.7 | -0.7 | -0.5 | 0.4 | -0.6 |
| Std. dev. reaction times | 0.3 | 0.4 | 0.7 | -0.7 | -0.6 | 0.5 | -0.5 | 0.5 | -0.4 | -0.6 | -0.6 | -0.6 | 0.7 | -0.8 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.5 | -0.5 | -0.3 | 0.6 | -0.6 | 0.7 | -0.2 | -0.5 | -0.6 | 0.1 | 0.7 | -0.5 |
| Context. condit. distance diff. score | 0.3 | 0.3 | 0.5 | 0.6 | 0.6 | -0.6 | 0.6 | -0.6 | 0.7 | 0.6 | 0.6 | 0.3 | -0.6 | 0.5 |
| Locomotion distance, session 7 | 0.3 | 0.3 | 1.4 | 0.5 | 0.8 | -0.1 | 0.1 | -0.2 | 1.2 | 0.6 | 0.6 | 0.8 | 0.0 | 0.3 |
| Degree of sensitization distance | 0.3 | 0.3 | 0.5 | 0.6 | 0.5 | -0.6 | 0.6 | -0.7 | 0.4 | 0.5 | 0.5 | -0.0 | -0.6 | 0.6 |
| Total zone transitions, NPP test | 0.3 | 0.5 | 2.4 | -0.2 | -0.5 | -0.3 | 0.3 | -0.2 | -1.4 | -0.2 | -0.3 | -1.5 | -0.2 | 0.3 |
| Pavlov. Cond. lever latency | 0.3 | 0.4 | 1.4 | 0.3 | 0.7 | 0.4 | -0.4 | 0.3 | 1.1 | 0.4 | 0.4 | 1.2 | 0.4 | 0.1 |
| Bone: elastic displacement | 0.3 | 0.3 | 0.4 | -0.6 | -0.7 | 0.5 | -0.5 | 0.4 | -0.6 | -0.7 | -0.7 | -0.3 | 0.5 | -0.6 |
| Bone: periosteal estimation | 0.3 | 0.6 | 1.7 | 0.1 | -0.4 | -1.1 | 1.1 | -1.0 | -0.5 | 0.0 | 0.0 | -1.3 | -1.0 | 0.2 |
| Distance traveled before self-admin | 0.3 | 0.3 | 0.8 | 0.3 | 0.2 | -0.7 | 0.7 | -0.9 | -0.2 | 0.5 | 0.3 | -0.6 | -0.9 | 0.5 |
| Time to tail flick, test, after self-admin | 0.3 | 0.3 | 0.6 | -0.6 | -0.7 | 0.2 | -0.3 | 0.7 | -0.7 | -0.6 | -0.7 | -0.8 | 0.5 | -0.5 |
| Ambulatory time before self-admin | 0.3 | 0.3 | 0.7 | 0.3 | 0.3 | -0.6 | 0.7 | -0.8 | -0.1 | 0.5 | 0.4 | -0.4 | -0.7 | 0.5 |
| Seeking ratio, punishment vs. effort | 0.3 | 0.4 | 0.7 | -0.7 | -0.8 | 0.3 | -0.4 | 0.4 | -0.8 | -0.7 | -0.8 | -0.6 | 0.3 | -0.6 |
| Sr content in liver | 0.3 | 0.3 | 1.4 | 0.3 | 0.7 | 0.3 | -0.3 | 0.3 | 0.9 | 0.4 | 0.4 | 1.2 | 0.2 | 0.1 |
| Indifference point function ln k | 0.2 | 0.2 | 0.4 | 0.5 | 0.3 | -0.6 | 0.6 | -0.5 | 0.6 | 0.4 | 0.4 | 0.3 | -0.6 | 0.4 |
| Indifference point function log k | 0.2 | 0.2 | 0.4 | 0.5 | 0.3 | -0.6 | 0.6 | -0.5 | 0.6 | 0.4 | 0.4 | 0.3 | -0.6 | 0.4 |
| Delay discounting total patch changes 6 sec | 0.2 | 0.3 | 0.5 | -0.7 | -0.6 | 0.6 | -0.6 | 0.5 | -0.7 | -0.7 | -0.6 | -0.1 | 0.6 | -0.6 |
| Reaction time num false alarms | 0.2 | 0.3 | 1.5 | 0.4 | 0.5 | -0.1 | 0.1 | -0.1 | 1.2 | 0.4 | 0.4 | 1.1 | -0.2 | 0.0 |
| Median of all reaction times | 0.2 | 0.3 | 1.0 | 0.1 | -0.1 | -0.7 | 0.7 | -0.7 | -0.3 | 0.1 | 0.2 | -1.0 | -0.5 | 0.3 |
| Intermitt. access day 1 inactive lever presses | 0.2 | 0.2 | 0.7 | -0.4 | 0.2 | 0.7 | -0.5 | 0.4 | 0.5 | -0.0 | -0.2 | 0.9 | 0.5 | -0.5 |
| Intermittent access total infusions | 0.2 | 0.2 | 0.4 | -0.4 | -0.2 | 0.5 | -0.5 | 0.5 | -0.0 | -0.3 | -0.5 | 0.2 | 0.7 | -0.5 |
| Baseline Anxiety | 0.2 | 0.2 | 0.6 | 0.1 | 0.3 | 0.4 | -0.5 | 0.6 | 0.7 | 0.1 | 0.1 | 0.8 | 0.6 | -0.2 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 0.6 | -0.3 | 0.2 | 0.5 | -0.4 | 0.2 | 0.4 | 0.0 | -0.2 | 0.8 | 0.2 | -0.4 |
| Incentive Sensitization - Breakpoint | 0.2 | 0.2 | 0.4 | -0.4 | 0.1 | 0.6 | -0.4 | 0.3 | 0.2 | -0.1 | -0.3 | 0.7 | 0.3 | -0.5 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.5 | 0.5 | 0.5 | -0.2 | 0.2 | -0.1 | 0.7 | 0.5 | 0.4 | 0.5 | -0.0 | 0.4 |
| Progressive ratio test 1 breakpoint | 0.2 | 0.2 | 0.6 | 0.5 | 0.6 | -0.4 | 0.3 | -0.2 | 0.7 | 0.5 | 0.5 | 0.4 | -0.2 | 0.5 |
| Progressive ratio test 2 active lever presses | 0.2 | 0.2 | 0.4 | -0.3 | 0.2 | 0.5 | -0.4 | 0.4 | 0.4 | -0.0 | -0.2 | 0.7 | 0.5 | -0.4 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.2 | 0.3 | -0.5 | -0.2 | 0.5 | -0.4 | 0.4 | -0.0 | -0.3 | -0.5 | 0.2 | 0.5 | -0.6 |
| Number of responses in last shaping day | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | 0.4 | -0.3 | 0.2 | -0.2 | -0.4 | -0.7 | -0.2 | 0.3 | -0.5 |
| Locomotion distance, session 8 | 0.2 | 0.3 | 1.0 | -0.5 | -0.6 | 0.2 | -0.2 | 0.2 | -1.0 | -0.5 | -0.5 | -0.8 | 0.2 | -0.3 |
| Pavlov. Cond. intertrial magazine entries | 0.2 | 0.3 | 1.1 | 0.0 | 0.4 | 0.6 | -0.6 | 0.6 | 0.6 | 0.1 | 0.1 | 1.1 | 0.6 | -0.2 |
| Bone: cortical thickness | 0.2 | 0.2 | 0.9 | 0.2 | 0.6 | 0.3 | -0.3 | 0.2 | 1.0 | 0.4 | 0.4 | 0.9 | 0.3 | -0.0 |
| Delta time to tail flick, test, before/after SA | 0.2 | 0.2 | 0.6 | -0.1 | 0.3 | 0.4 | -0.5 | 0.6 | 0.6 | 0.1 | 0.1 | 0.7 | 0.5 | -0.2 |
| Total resting periods, locomotor time 1 | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | 0.5 | -0.5 | 0.4 | -0.2 | -0.4 | -0.5 | -0.2 | 0.4 | -0.6 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.4 | -0.6 | -0.5 | 0.4 | -0.3 | 0.4 | -0.6 | -0.5 | -0.6 | -0.4 | 0.2 | -0.5 |
| Locomotion in novel chamber | 0.2 | 0.3 | 0.8 | -0.3 | 0.2 | 0.8 | -0.7 | 0.5 | 0.0 | -0.1 | -0.2 | 0.9 | 0.6 | -0.3 |
| Se content in liver | 0.2 | 0.2 | 0.2 | -0.5 | -0.5 | 0.4 | -0.4 | 0.4 | -0.5 | -0.4 | -0.5 | -0.4 | 0.3 | -0.4 |
| Epididymis fat weight | 0.1 | 0.3 | 0.9 | -0.3 | 0.2 | 0.8 | -0.8 | 1.0 | 0.1 | -0.1 | -0.2 | 0.8 | 0.8 | -0.3 |
| Left kidney weight | 0.1 | 0.3 | 1.0 | -0.5 | -0.7 | 0.1 | -0.1 | -0.1 | -0.9 | -0.6 | -0.6 | -1.0 | 0.1 | -0.4 |
| Mean num. licks in bursts | 0.1 | 0.1 | 0.4 | 0.0 | -0.2 | -0.3 | 0.3 | -0.4 | -0.2 | -0.0 | -0.0 | -0.6 | -0.3 | 0.1 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.3 | 0.3 | 0.0 | -0.5 | 0.5 | -0.5 | -0.1 | 0.2 | 0.2 | -0.1 | -0.5 | 0.4 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.1 | 0.2 | 0.3 | 0.1 | -0.4 | 0.3 | -0.4 | 0.1 | 0.2 | 0.2 | 0.1 | -0.4 | 0.3 |
| Delay discounting total patch changes 24 sec | 0.1 | 0.1 | 0.1 | -0.2 | -0.2 | 0.3 | -0.3 | 0.3 | -0.3 | -0.2 | -0.2 | 0.2 | 0.3 | -0.2 |
| Locomotor testing rearing | 0.1 | 0.1 | 0.8 | -0.0 | 0.2 | 0.3 | -0.4 | 0.3 | 0.5 | 0.1 | 0.1 | 0.9 | 0.3 | -0.2 |
| Reaction time mean | 0.1 | 0.2 | 1.0 | -0.4 | -0.5 | -0.2 | 0.2 | -0.2 | -0.5 | -0.3 | -0.2 | -1.0 | 0.0 | -0.3 |
| Reaction time mean AUC | 0.1 | 0.2 | 1.1 | -0.3 | -0.5 | -0.3 | 0.3 | -0.3 | -0.5 | -0.3 | -0.2 | -1.1 | -0.1 | -0.3 |
| Saline control response | 0.1 | 0.1 | 0.3 | 0.4 | 0.5 | -0.1 | 0.1 | -0.2 | 0.3 | 0.4 | 0.4 | 0.5 | -0.1 | 0.4 |
| Lifetime Intake | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | 0.3 | -0.3 | 0.3 | -0.0 | -0.2 | -0.4 | 0.1 | 0.4 | -0.3 |
| Total sessions with >9 infusions | 0.1 | 0.1 | 0.4 | -0.2 | -0.4 | -0.2 | 0.1 | -0.3 | -0.4 | -0.2 | -0.4 | -0.6 | -0.3 | -0.1 |
| Short access day 10 total inactive lever presses | 0.1 | 0.1 | 0.3 | -0.1 | 0.4 | 0.4 | -0.2 | 0.2 | 0.2 | 0.2 | 0.1 | 0.6 | 0.2 | -0.1 |
| One hour access (0.3 mA shock) | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | -0.5 | 0.6 | -0.3 | 0.4 | 0.5 | 0.3 | -0.0 | -0.3 | 0.4 |
| One hour access (shock baseline) | 0.1 | 0.1 | 0.3 | -0.1 | 0.2 | 0.3 | -0.3 | 0.5 | 0.6 | 0.0 | -0.1 | 0.5 | 0.6 | -0.2 |
| Bone: elastic work | 0.1 | 0.2 | 0.4 | 0.2 | -0.2 | -0.6 | 0.6 | -0.6 | -0.1 | 0.0 | 0.0 | -0.6 | -0.5 | 0.2 |
| Bone: endosteal estimation | 0.1 | 0.3 | 0.7 | 0.3 | 0.0 | -0.8 | 0.8 | -0.7 | 0.0 | 0.3 | 0.3 | -0.5 | -0.7 | 0.3 |
| Bone: marrow area | 0.1 | 0.3 | 0.7 | 0.3 | 0.1 | -0.8 | 0.9 | -0.7 | 0.0 | 0.3 | 0.3 | -0.5 | -0.7 | 0.3 |
| Bone: minimum diameter | 0.1 | 0.2 | 0.6 | -0.4 | -0.7 | -0.3 | 0.3 | -0.2 | -0.6 | -0.4 | -0.4 | -0.8 | -0.2 | -0.4 |
| Delay disc. indifference point, 16s delay | 0.1 | 0.1 | 0.2 | 0.3 | 0.1 | -0.4 | 0.4 | -0.4 | 0.2 | 0.2 | 0.4 | -0.0 | -0.5 | 0.2 |
| Bouts of movement, locomotor time 1 | 0.1 | 0.1 | 0.2 | -0.4 | -0.2 | 0.5 | -0.5 | 0.4 | -0.0 | -0.2 | -0.3 | 0.0 | 0.4 | -0.4 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.5 | 0.3 | 0.3 | -0.2 | 0.2 | -0.3 | 0.7 | 0.3 | 0.2 | 0.5 | -0.1 | 0.0 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.3 | -0.2 | -0.1 | 0.3 | -0.2 | 0.4 | -0.6 | -0.2 | -0.3 | -0.3 | 0.3 | -0.1 |
| Cd content in liver | 0.1 | 0.2 | 0.3 | 0.3 | 0.2 | -0.5 | 0.5 | -0.5 | 0.0 | 0.3 | 0.3 | -0.4 | -0.5 | 0.4 |
| Fe content in liver | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | -0.3 | 0.3 | 0.4 | 0.2 | 0.1 | 0.4 | 0.3 | 0.0 |
| Reaction time false alarm rate | 0.0 | 0.0 | 0.1 | 0.0 | -0.0 | -0.1 | 0.1 | -0.1 | 0.2 | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 |
| Intermittent access day 1 total infusions | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | -0.2 | 0.3 | -0.1 | 0.0 | 0.1 | 0.0 | -0.2 | -0.1 | 0.2 |
| Progressive ratio test 1 inactive lever presses | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.0 | 0.1 | -0.1 | -0.1 | -0.2 | -0.2 | 0.1 | -0.1 |
| Progressive ratio test 2 inactive lever presses | 0.0 | 0.1 | 0.2 | -0.3 | -0.2 | 0.1 | -0.0 | 0.0 | -0.3 | -0.2 | -0.4 | -0.2 | 0.2 | -0.2 |
| Short access day 1 total inactive lever presses | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 | 0.2 | -0.2 | -0.2 | -0.2 | -0.0 | 0.2 | 0.0 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.2 | -0.0 | 0.1 | 0.2 | -0.1 | 0.3 | 0.4 | 0.1 | -0.1 | 0.3 | 0.3 | -0.0 |
| Short access total infusions | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 | 0.0 | -0.1 | -0.2 | -0.1 | -0.2 | -0.2 | -0.1 | -0.0 |
| Locomotion distance, session 3 | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 | 0.0 | 0.4 | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 |
| Pavlov. Cond. change in total contacts | 0.0 | 0.0 | 0.1 | -0.3 | -0.3 | 0.2 | -0.2 | 0.2 | -0.4 | -0.3 | -0.3 | -0.0 | 0.1 | -0.2 |
| Time in closed arm after self-admin | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.1 | -0.2 | 0.2 | 0.2 | -0.0 | 0.1 | 0.3 | 0.1 | 0.0 |
| Sum of active levers in priming session hrs 5-6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | 0.0 | -0.1 | -0.1 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.