Hub : Genes

Arih2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr8:109349078:109351275	0.02	0.02	9.8e-03	0.01	0.01	0	0.01	1.3e-02	2.4e-02	3.5e-01	4.3e-02
2	Liver	gene expression	ENSRNOG00000031827	0.04	0.03	5.7e-04	0.02	0.01	0.01	0.01	6.1e-03	8.0e-03	1.1e-02	1.9e-02
3	NAcc	intron excision ratio	chr8:109314456:109327204	0.05	0.04	8.9e-03	0.01	0.02	0.01	0.01	1.0e-01	1.5e-02	2.3e-02	3.8e-02
4	OFC	intron excision ratio	chr8:109314456:109327204	0.2	0.11	1.4e-03	0.1	0.11	0.06	0.09	2.0e-03	1.7e-03	1.9e-02	4.8e-03
5	OFC	intron excision ratio	chr8:109314456:109348726	0.15	0.1	5.9e-03	0.05	0.06	0.07	0.06	2.1e-02	1.3e-02	1.0e-02	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.2	0.6	1.0	-1.0	-0.7	0.6	-0.7	0.7
BMI without tail	0.7	1.4	3.0	-0.1	-1.2	0.4	-1.7	1.6
Body weight	1.9	8.0	17.5	-1.0	-0.6	2.6	-3.8	4.2
Epididymis fat weight	0.1	0.2	0.3	-0.4	-0.0	0.4	-0.4	0.6
Glucose	1.1	1.6	2.3	1.4	-1.5	-1.2	-1.2	0.9
Heart weight	1.4	2.0	4.1	-1.5	1.2	2.0	-0.9	1.1
Left kidney weight	1.2	3.6	6.4	1.3	-2.5	-1.3	-2.1	1.9
Right kidney weight	1.0	2.8	5.3	1.5	-2.3	-1.7	-1.5	1.3
Tail length	2.4	7.4	17.6	1.0	-1.0	1.2	-4.0	4.2
Length with tail	3.0	10.9	26.7	0.4	-0.7	2.2	-4.7	5.2
Length without tail	2.0	4.3	10.4	-0.3	0.1	1.9	-2.8	3.2
Liver weight, left	0.9	1.5	3.2	1.8	-1.1	-1.3	-0.9	0.8
Liver weight, right	1.7	2.9	4.0	1.6	-1.7	-1.0	-2.0	2.0
Parametrial fat weight	0.7	1.4	2.7	0.9	-1.1	-0.1	-1.6	1.7
Retroperitoneal fat weight	0.3	1.1	1.8	0.8	-1.1	-0.5	-1.3	1.3
Intraocular pressure	0.8	1.1	1.8	1.3	-0.3	-0.4	-1.2	1.3
Extensor digitorum longus weight	0.3	1.1	1.5	-1.2	1.1	0.9	1.1	-0.9
Soleus weight	1.1	3.3	7.5	-0.2	-0.5	1.4	-2.6	2.7
Tibialis anterior weight	0.1	0.4	0.8	-0.9	0.5	0.8	0.2	-0.1
Tibia length	2.5	7.0	16.0	0.2	-1.7	1.2	-3.8	4.0
Number of licking bursts	1.8	2.2	3.4	-1.6	1.8	1.6	1.2	-0.9
Food consumed during 24 hour testing period	0.4	0.5	1.2	-0.1	-0.1	0.5	-1.0	1.1
Times rat made contact with spout	0.3	0.3	0.7	-0.3	0.4	0.8	-0.5	0.6
Mean time between licks in bursts	0.6	0.8	1.9	-0.4	0.4	-0.4	1.3	-1.4
Mean num. licks in bursts	2.0	2.4	3.1	1.6	-1.8	-1.3	-1.6	1.4
Std. dev. time between licks in bursts	4.8	5.7	8.7	-2.3	2.3	1.1	2.9	-2.9
Water consumed over 24 hours	1.0	1.2	2.1	-1.5	1.2	1.4	0.6	-0.4
Indifference point 0 sec	1.8	2.8	4.1	1.8	-1.4	-0.9	-2.0	2.0
Indifference point AUC	1.1	1.3	2.2	1.3	-1.5	-1.2	-0.8	0.6
Indifference point function ln k	0.2	0.3	0.6	-0.6	-0.1	-0.2	0.6	-0.8
Indifference point function log k	0.2	0.3	0.6	-0.6	-0.1	-0.2	0.6	-0.8
Delay discounting total patch changes 0 sec	1.3	2.1	3.7	1.5	-1.0	-0.5	-1.9	1.9
Delay discounting total patch changes 12 sec	0.7	0.9	1.8	0.9	-0.6	-0.1	-1.3	1.3
Delay discounting total patch changes 18 sec	2.0	2.6	3.8	1.9	-1.2	-0.7	-1.9	1.9
Delay discounting total patch changes 24 sec	1.0	1.3	3.1	0.5	-0.5	0.4	-1.6	1.8
Delay discounting total patch changes 6 sec	1.6	2.4	4.0	2.0	-1.6	-1.4	-1.3	1.3
Delay discounting time to switch 0 sec	0.9	1.4	2.2	-1.3	1.5	1.3	1.0	-0.8
Delay discounting water rate 0 sec	0.1	0.1	0.2	0.2	-0.0	0.0	-0.4	0.5
Delay discounting water rate 12 sec	0.0	0.1	0.1	-0.1	-0.2	0.1	-0.4	0.3
Delay discounting water rate 18 sec	0.5	0.6	1.6	-1.2	0.6	0.9	0.4	-0.4
Delay discounting water rate 24 sec	0.2	0.3	0.6	-0.2	0.1	0.6	-0.7	0.8
Delay discounting water rate 6 sec	0.2	0.2	0.5	0.4	-0.7	-0.4	-0.5	0.3
Locomotor activity	2.1	3.3	7.7	0.7	-0.8	0.6	-2.8	2.7
Locomotor testing distance	2.0	3.4	7.7	0.8	-1.0	0.2	-2.7	2.8
Locomotor testing rearing	0.0	0.1	0.1	0.1	0.3	0.2	-0.2	0.3
Light reinforcement 1	0.2	0.4	1.0	0.1	-0.4	0.4	-1.0	0.9
Light reinforcement 2	0.7	0.9	2.1	0.8	-1.5	-1.2	-0.2	-0.2
Reaction time number correct	0.5	0.7	1.3	-0.4	0.8	0.2	1.1	-1.1
Reaction time mean minus median	0.2	0.2	0.5	0.2	-0.7	-0.4	-0.5	0.4
Reaction time mean minus median AUC	0.4	0.5	0.7	0.6	-0.8	-0.5	-0.8	0.7
Reaction time num false alarms	0.1	0.1	0.3	0.2	0.2	-0.6	0.3	-0.4
Reaction time num false alarms AUC	0.2	0.2	0.6	0.6	-0.2	-0.8	-0.1	0.1
Reaction time trials correct on left	0.5	0.7	1.3	-0.4	0.8	0.2	1.1	-1.1
Reaction time trials on left	0.5	0.7	1.3	-0.4	0.7	0.1	1.1	-1.1
Reaction time mean	0.1	0.2	0.3	0.5	-0.4	-0.6	-0.2	0.2
Reaction time mean AUC	0.3	0.4	0.7	0.7	-0.6	-0.9	-0.2	0.2
Median of all reaction times	0.1	0.1	0.3	0.5	-0.2	-0.6	-0.1	0.1
Reaction time omissions	0.1	0.1	0.4	0.2	0.6	-0.1	0.4	-0.3
Reaction time false alarm rate	0.1	0.2	0.4	0.5	-0.2	-0.6	-0.3	0.3
Reaction time premature initiation rate	1.0	1.3	3.1	0.5	-0.7	0.5	-1.6	1.8
Reaction time premature initiations	0.3	0.4	1.0	0.1	-0.2	0.6	-0.9	1.0
Std. dev. reaction times	0.5	0.7	0.9	0.9	-1.0	-0.9	-0.7	0.7
Reaction time trials completed	0.5	0.7	1.3	-0.4	0.7	0.1	1.1	-1.1
Reaction time trials AUC	0.5	0.7	1.6	-0.4	0.7	0.0	1.2	-1.3
Social response proportion	0.1	0.2	0.3	0.2	0.2	0.5	-0.4	0.6
Social responses	0.3	0.4	0.7	0.5	-0.5	-0.1	-0.9	0.8
Social time	1.8	2.3	3.8	-1.9	1.6	1.6	1.3	-1.1
Conditioned locomotion	1.0	1.2	2.4	0.6	-0.2	-1.2	1.3	-1.5
Cocaine response after cond. corrected	1.8	2.0	4.2	-1.7	1.6	2.1	0.4	-0.1
Cocaine response after cond. not corrected	1.2	1.3	3.1	-1.2	0.9	1.8	-0.6	0.9
Cocaine response before conditioning	1.4	1.7	2.4	1.1	-1.5	-0.9	-1.5	1.4
Saline control response	2.7	3.6	5.2	2.3	-1.7	-1.4	-2.0	1.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.8	-0.1	-0.3	0.7	-1.1	1.3
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.0	-0.6	0.0	1.0	-0.8	1.0
Condit. Reinf. active responses	0.6	0.8	2.0	0.1	-0.2	0.7	-1.2	1.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	0.0	-0.1	0.0	0.0
Condit. Reinf. lever presses	0.7	1.0	2.5	-0.2	-0.4	0.7	-1.3	1.6
Condit. Reinf. lever reinforcers received	0.6	0.9	2.3	0.1	-0.2	0.8	-1.3	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.2	0.3	-0.2	0.5	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.8	0.1	0.2	0.5	-0.6
Pavlov. Cond. change in total contacts	0.7	0.9	1.9	-0.4	-0.1	1.0	-1.2	1.4
Pavlov. Cond. index score	0.2	0.2	0.7	-0.9	0.1	0.5	0.0	0.0
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.8	0.1	0.4	0.1	-0.0
Pavlov. Cond. lever contacts	0.4	0.6	1.2	0.2	-0.7	-0.0	-1.0	1.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.8	-0.3	-0.2	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.1	0.7	-0.1	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	-0.9	0.1	0.5	0.1	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.6	-0.1	0.2	0.0	0.0
Conditioned reinforcement - actives	0.1	0.1	0.2	0.2	-0.2	-0.5	0.3	-0.3
Conditioned reinforcement - inactives	3.0	3.4	4.6	-2.1	2.1	1.5	1.8	-1.6
Conditioned locomotion	0.7	0.8	1.5	1.1	-1.1	-1.2	-0.1	-0.1
Intermittent access intake day 1-15 change	2.7	2.7	3.8	-2.0	2.0	1.4	1.5	-1.3
Intermittent access intake escalation	2.1	2.1	2.9	-1.7	1.7	1.2	1.3	-1.2
Intermittent access intake escalation 2	2.3	2.3	3.5	-1.9	1.9	1.7	1.0	-0.7
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	0.0
Intermitt. access day 15 inactive lever presses	1.6	1.8	2.2	-1.5	1.5	1.3	1.3	-1.0
Intermitt. access escalation Index	0.4	0.4	0.7	0.8	-0.8	-0.6	-0.4	0.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.1	0.2
Intermittent access day 15 total infusions	0.4	0.5	0.6	-0.8	0.8	0.5	0.8	-0.7
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	0.3	0.2	0.4	-0.3
Intermittent access total infusions	0.1	0.1	0.3	-0.3	0.3	0.0	0.6	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.5	-0.5	-0.4	0.0	0.0
Intermittent access day 15 total locomotion	0.6	0.6	1.4	0.7	-0.7	-1.2	0.5	-0.7
Intermittent access total locomotion	0.6	0.7	1.6	0.8	-0.8	-1.3	0.5	-0.7
Intermittent access standard deviation	2.4	2.6	4.8	-2.0	2.0	2.2	0.7	-0.2
Cocaine induced anxiety	0.5	0.6	0.9	-1.0	1.0	0.9	0.4	-0.3
Post-drug Anxiety	0.2	0.2	0.3	-0.6	0.6	0.5	0.3	-0.2
Baseline Anxiety	0.3	0.3	0.6	0.2	-0.2	-0.8	0.6	-0.8
Lifetime Intake	0.1	0.1	0.2	0.0	-0.0	-0.3	0.5	-0.4
Incentive Sensitization - Responses	1.0	1.0	1.7	-1.0	1.0	0.4	1.3	-1.2
Incentive Sensitization - Breakpoint	1.0	1.0	1.6	-1.0	1.0	0.5	1.3	-1.2
Progressive ratio test 1 active lever presses	0.7	0.7	1.1	1.0	-1.0	-1.1	-0.5	0.4
Progressive ratio test 1 breakpoint	0.7	0.7	1.3	1.0	-1.0	-1.1	-0.4	0.3
Progressive ratio test 1 inactive lever presses	0.7	0.7	0.9	-1.0	1.0	0.7	0.9	-0.7
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	-0.1	0.1	-0.3	0.6	-0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.2	0.2	-0.1	0.6	-0.5
Progressive ratio test 2 inactive lever presses	3.0	3.4	4.2	-2.1	2.1	1.6	1.9	-1.6
Total sessions with >9 infusions	1.0	1.1	1.5	-1.2	1.2	1.1	0.9	-0.7
Short access day 1 total inactive lever presses	2.8	3.2	6.6	-1.2	1.2	-0.3	2.5	-2.6
Short access day 10 total inactive lever presses	2.5	2.8	5.3	-2.0	2.0	2.3	0.8	-0.4
Short access day 1 total infusions	0.6	0.6	1.3	-0.5	0.5	0.1	1.1	-1.1
Short access day 10 total infusions	0.1	0.1	0.3	0.4	-0.4	-0.6	0.1	-0.1
Short access total infusions	0.3	0.4	0.7	0.4	-0.4	-0.9	0.6	-0.7
Short access day 1 locomotion	0.0	0.0	0.1	0.0	-0.0	0.2	0.3	-0.2
Short access day 10 total locomotion	0.7	0.8	1.3	1.1	-1.1	-1.0	-0.5	0.4
Short access total locomotion	0.9	0.9	1.5	1.2	-1.2	-1.1	-0.6	0.5
Compulsive drug intake	1.0	0.9	1.7	1.2	-1.2	-1.3	-0.1	-0.2
One hour access (0.3 mA shock)	0.3	0.4	0.7	0.7	-0.7	-0.8	0.2	-0.3
One hour access (shock baseline)	0.1	0.1	0.1	-0.3	0.3	0.3	0.1	0.0
Number of responses in last shaping day	0.9	0.9	1.0	-1.0	1.0	0.8	1.0	-0.9
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	0.2	0.3	0.1	-0.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.4	-0.6	-0.6	-0.1	-0.0
Locomotion distance, session 1	1.2	1.6	2.7	0.9	-1.7	-0.9	-1.4	1.3
Locomotion velocity, session 2	0.2	0.2	0.4	-0.6	0.1	-0.0	0.5	-0.6
Locomotion distance, session 2	0.6	0.9	2.1	0.7	-1.5	-1.3	-0.4	0.2
Locomotion velocity, session 3	1.3	1.6	3.3	1.0	-1.8	-1.4	-0.9	0.7
Locomotion distance, session 3	0.9	0.9	2.3	0.5	-1.2	-1.5	0.5	-0.7
Stereotopy head waving bouts, day 3	1.7	2.0	3.6	-1.7	1.8	1.9	0.7	-0.4
Stereotopy head waving duration, day 3	0.5	0.6	1.5	-0.6	1.1	1.2	0.0	0.2
Locomotion velocity, session 7	1.3	1.5	2.3	1.5	-1.4	-1.4	-0.8	0.7
Locomotion distance, session 7	0.6	0.8	2.0	0.7	-0.8	-1.4	0.6	-0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.5	-0.4	-0.5	-0.1	-0.1
Stereotopy head waving duration, day 7	0.3	0.3	0.5	0.6	-0.6	-0.2	-0.7	0.6
Locomotion velocity, session 8	0.8	1.0	2.4	0.7	-1.6	-0.9	-0.8	0.7
Locomotion distance, session 8	1.9	2.8	5.8	1.4	-2.4	-1.8	-1.3	1.0
Degree of sensitization distance	0.4	0.4	0.8	0.4	0.2	0.6	-0.8	0.9
Degree of sensitization stereotypy	0.8	0.9	1.5	1.2	-1.1	-1.1	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.5	0.5	1.1	-0.6	1.0	1.0	0.3	-0.0
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.4	-1.0	1.5	1.5	0.3	0.1
Condit. Reinf. active responses	0.3	0.4	0.6	-0.6	0.8	0.7	0.5	-0.4
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.1	-0.4	-0.6	0.5	-0.7
Incentive salience index mean	0.3	0.3	0.4	-0.6	0.6	0.6	0.5	-0.4
Condit. Reinf. lever presses	0.5	0.7	1.7	-0.5	0.3	-0.2	1.2	-1.3
Time in familiar zone, hab. session 1	1.8	1.7	2.6	-0.9	1.6	0.8	1.6	-1.4
Time in novel zone, hab. session 1	0.4	0.4	0.9	0.2	-0.6	-0.0	-0.9	1.0
Total zone transitions, hab. session 1	1.2	1.7	3.3	1.0	-1.8	-1.1	-1.3	1.2
Total locomotion distance, hab. session 1	0.5	0.7	1.2	0.6	-1.1	-0.6	-0.9	0.8
Locomotion velocity, hab. session 1	0.8	1.1	1.9	0.9	-1.4	-0.9	-1.0	0.9
Time in familiar zone, hab. session 2	1.6	1.7	2.1	-1.3	1.5	1.0	1.4	-1.3
Time in novel zone, hab. session 2	0.5	0.6	0.9	1.0	-0.7	-0.8	-0.6	0.5
Total zone transitions, hab. session 2	0.2	0.3	0.8	-0.0	-0.9	-0.5	-0.4	0.3
Total locomotion distance, hab. session 2	0.5	0.6	1.2	0.5	-1.1	-0.6	-0.9	0.8
Locomotion velocity, hab. session 2	0.5	0.7	1.5	0.6	-1.2	-0.7	-0.9	0.8
Novel to familiar place preference ratio	5.6	5.9	9.0	3.0	-2.8	-2.6	-2.0	1.4
Novelty place preference	6.3	6.6	10.2	3.2	-2.9	-2.8	-2.0	1.5
Time in novel zone, NPP test	5.4	5.7	8.9	3.0	-2.6	-2.4	-2.0	1.6
Total zone transitions, NPP test	3.1	4.5	7.9	1.4	-2.8	-1.5	-2.4	2.1
Total locomotion distance, NPP test	0.9	1.2	2.1	0.6	-1.3	-0.5	-1.4	1.3
Locomotion velocity, NPP test	1.2	1.8	2.8	0.9	-1.7	-0.8	-1.6	1.4
Pavlov. Cond. lever latency	2.4	3.0	6.6	1.4	-0.7	0.2	-2.4	2.6
Pavlov. Cond. magazine entry latency	3.9	5.0	9.4	-1.9	1.6	0.4	3.1	-3.0
Pavlov. Cond. change in total contacts	1.6	1.7	2.8	-1.1	1.3	0.6	1.7	-1.6
Pavlov. Cond. index score	3.9	5.0	9.3	-1.9	1.6	0.4	3.0	-3.1
Pavlov. Cond. latency score	3.3	4.2	8.5	-1.6	1.3	0.1	2.9	-2.9
Pavlov. Cond. lever contacts	1.4	1.7	3.4	-1.1	0.6	0.0	1.8	-1.9
Pavlov. Cond. magazine entry number	4.2	5.3	10.6	1.7	-1.6	-0.3	-3.2	3.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.5	-0.4	-0.3	-0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	4.4	5.5	9.2	-2.2	1.9	0.8	3.0	-3.0
Pavlov. Cond. response bias	4.6	5.6	10.2	-2.1	1.8	0.6	3.2	-3.2
Bone: apparent density	0.7	1.2	1.9	1.4	-1.3	-1.4	-0.7	0.3
Bone surface	0.1	0.1	0.2	0.0	-0.5	-0.4	0.1	-0.3
Bone volume	0.1	0.3	0.6	0.4	-0.7	-0.7	-0.1	-0.2
Bone: connectivity density	1.2	1.8	3.7	1.9	-1.4	-1.9	-0.3	0.0
Bone: cortical apparent density	0.1	0.2	0.4	0.6	-0.2	-0.7	0.2	-0.3
Bone: cortical area	2.1	3.2	5.1	-2.3	2.0	1.9	1.4	-1.2
Bone: cortical porosity	1.5	1.6	3.5	1.9	-1.2	-1.6	-0.6	0.4
Bone: cortical porosity	1.6	1.7	3.7	1.9	-1.2	-1.8	-0.4	0.2
Bone: cortical thickness	2.3	3.8	6.6	-2.5	2.2	2.6	0.9	-0.6
Bone: cortical thickness	0.1	0.1	0.1	-0.4	0.4	0.4	0.3	-0.3
Bone: cortical tissue density	0.2	0.2	0.6	0.7	-0.3	-0.8	0.2	-0.2
Bone: elastic displacement	0.6	0.7	1.2	-1.0	1.0	1.1	0.4	-0.3
Bone: elastic work	0.5	0.7	1.6	-1.2	0.6	1.3	-0.0	0.1
Bone: endosteal estimation	0.2	0.5	1.0	1.0	-0.8	-0.7	-0.6	0.5
Bone: endosteal perimeter	0.3	0.7	1.7	-0.2	0.1	-0.7	1.2	-1.3
Bone: final force	0.8	1.4	3.5	-1.4	1.0	1.9	-0.4	0.6
Bone: final moment	1.1	1.7	4.4	-1.6	1.1	2.1	-0.4	0.7
Bone: marrow area	0.3	0.6	1.0	1.0	-0.8	-0.8	-0.6	0.5
Bone: maximum diameter	1.2	2.1	3.2	-1.8	1.5	1.3	1.4	-1.2
Bone: maximum force	0.3	0.6	1.5	-0.7	0.5	1.2	-0.5	0.6
Bone: maximum moment	0.4	0.7	1.9	-0.9	0.6	1.4	-0.5	0.6
Bone: minimum diameter	0.3	0.6	1.1	-0.8	0.5	0.1	1.0	-1.0
Bone: periosteal estimation	0.1	0.2	0.4	-0.6	0.5	0.6	0.3	-0.2
Bone: periosteal perimeter	0.8	1.4	2.4	-1.1	0.9	0.3	1.5	-1.5
Bone: post-yield work	0.0	0.0	0.2	0.1	-0.4	-0.1	-0.2	0.1
Bone: stiffness	0.0	0.1	0.1	-0.0	0.1	0.4	-0.3	0.3
Bone: tissue strength	1.4	1.3	3.2	-1.0	0.8	1.8	-0.8	1.1
Bone: trabecular number	1.2	1.9	4.5	1.5	-1.5	-2.1	0.1	-0.6
Bone: trabecular spacing	1.6	2.0	5.0	-1.5	1.4	2.2	-0.4	0.8
Bone: trabecular thickness	1.2	1.5	2.6	1.3	-1.6	-1.5	-0.8	0.4
Bone: trabecular tissue density	0.3	0.4	0.6	0.6	-0.6	-0.2	-0.8	0.7
Breakpoint value in progressive ratio session	0.3	0.4	0.5	0.7	-0.7	-0.4	-0.6	0.6
Distance traveled before self-admin	0.9	1.0	1.5	-1.2	1.2	1.0	0.7	-0.6
Distance traveled after self-admin	0.4	0.5	0.6	-0.7	0.7	0.4	0.8	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.4	-0.4	-0.5	0.5	-0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.4	-0.4	-0.2	-0.6	0.5
Diff in mean of infusions in LGA sessions	1.9	2.1	3.6	-1.8	1.8	1.9	0.7	-0.4
Extinction: sum of active levers before priming	0.6	0.6	0.9	0.9	-0.9	-0.9	-0.7	0.5
Active lever presses in extinction session 6	1.4	1.3	1.9	1.4	-1.4	-1.0	-1.0	1.0
Delta distance traveled before/after self-admin	0.1	0.2	0.3	0.5	-0.5	-0.5	-0.2	0.1
Delta ambulatory time before/after self-admin	0.5	0.5	0.8	0.8	-0.8	-0.4	-0.9	0.8
Time in closed arm before self-admin	0.5	0.5	1.4	-0.0	0.0	0.6	-1.0	1.2
Time in closed arm after self-admin	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.3
Time in open arm before self-admin	0.4	0.4	1.0	-0.3	0.3	-0.2	0.9	-1.0
Time in open arm after self-admin	1.4	1.6	2.8	1.6	-1.6	-1.7	-0.4	0.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.1	0.7	-0.7	-0.3	-1.0	1.0
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.9	0.4	-0.4	0.3	-1.3	1.4
Time to tail flick, vehicle, after self-admin	1.0	1.1	1.9	-1.1	1.1	1.4	-0.5	0.8
Time to tail flick, test, before self-admin	1.7	1.6	2.5	1.6	-1.6	-1.3	-1.0	0.7
Time to tail flick, test, after self-admin	0.3	0.4	0.6	-0.8	0.8	0.7	0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.9	-1.4	1.4	0.9	0.9	-0.7
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	-1.0	1.0	0.8	0.8	-0.6
Ambulatory time before self-admin	1.0	1.0	1.4	-1.2	1.2	0.9	1.0	-0.8
Ambulatory time after self-admin	0.0	0.0	0.0	0.2	-0.2	-0.2	0.1	-0.2
Total heroin consumption	0.5	0.6	0.8	-0.6	0.6	0.9	-0.7	0.8
Area under the delay curve	0.8	0.9	2.0	0.8	-0.8	-1.4	0.7	-0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.4	-0.4	-0.2	0.1	-0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.6	-0.6	-0.9	0.5	-0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.3	-0.3	-0.4	0.2	-0.3
Delay disc. indifference point, 24s delay	0.4	0.4	0.8	0.5	-0.5	-0.9	0.4	-0.6
Delay disc. indifference point, 4s delay	0.4	0.5	1.1	0.0	-0.0	-0.4	1.0	-1.0
Delay disc. indifference point, 8s delay	0.9	0.9	2.4	0.7	-0.7	-1.5	0.7	-0.9
Delay discount exponential model param	0.8	0.8	1.7	-0.6	0.6	1.3	-0.9	1.0
Delay discount hyperbolic model param	0.8	0.9	1.8	-0.6	0.6	1.3	-0.8	1.0
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.2	0.2	0.6	-0.6	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.5	-0.5	-0.6	-0.1	0.0
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.7	0.8	-0.8	-1.3	0.1	-0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	0.1	0.4	-0.2	0.1
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1	0.1
Rest time, locomotor task time 1	0.2	0.2	0.6	0.2	-0.2	-0.4	0.5	-0.8
Distance moved, locomotor task time 1	0.5	0.6	0.9	-0.5	0.5	0.9	-0.8	0.9
Vertical activity count, locomotor time 1	0.3	0.3	0.7	-0.1	0.1	0.3	-0.9	0.8
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.1	0.4	-0.4	0.1	-1.1	1.1
Bouts of movement, locomotor time 2	0.4	0.4	0.6	-0.8	0.8	0.8	0.5	-0.3
Total resting periods, locomotor time 2	0.4	0.4	0.5	-0.7	0.7	0.6	0.7	-0.5
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	-0.4	-0.3	0.0	-0.1
Distance moved, locomotor task time 2	0.3	0.4	0.6	-0.5	0.5	0.6	-0.6	0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	0.2
Weight adjusted by age	0.8	0.9	1.8	-1.1	1.1	1.3	-0.2	0.4
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.7	0.6	-0.6	-1.3	0.9	-1.2
Locomotion in novel chamber	0.5	0.6	0.7	-0.8	0.8	0.8	0.7	-0.6
Locomotion in novel chamber post-restriction	0.7	0.8	1.0	1.0	-1.0	-0.7	-1.0	0.8
Progressive ratio	2.0	2.3	4.7	1.1	-1.1	-0.2	-2.2	2.1
Food seeking constrained by brief footshock	0.5	0.6	1.5	-0.4	0.4	-0.1	1.1	-1.2
Seeking ratio, punishment vs. effort	3.3	4.0	7.9	-1.5	1.5	0.1	2.8	-2.8
Run reversals in cocaine runway, females	1.8	1.8	3.7	-1.0	1.0	-0.1	1.8	-1.9
Run reversals in cocaine runway, males	0.7	0.7	1.3	-0.8	0.8	1.1	-0.5	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.5	-0.0	0.0	0.5	-0.6	0.7
Latency to leave start box in cocaine runway, F	1.0	1.1	2.5	-1.0	1.0	1.6	-0.5	0.8
Latency to leave start box in cocaine runway, M	0.7	0.7	1.2	1.1	-1.1	-0.9	-0.3	0.1
Cd content in liver	1.2	1.3	2.9	-0.4	1.1	1.7	-0.9	1.2
Co content in liver	0.7	0.8	1.3	-1.1	1.0	1.0	0.6	-0.4
Cu content in liver	2.1	2.5	5.0	1.3	-1.0	0.0	-2.2	2.2
Fe content in liver	0.9	1.1	2.2	-0.1	1.1	1.5	-0.8	1.1
K content in liver	0.8	0.8	1.4	0.5	-1.2	-0.3	-1.2	1.0
Mg content in liver	0.3	0.3	0.9	0.1	-1.0	-0.6	-0.3	0.1
Mn content in liver	1.7	1.9	2.9	1.4	-1.7	-1.3	-1.3	1.2
Na content in liver	0.6	0.6	1.2	1.1	-0.4	-0.4	-0.9	0.9
Rb content in liver	1.1	1.3	3.1	-0.5	1.7	1.8	-0.2	0.7
Se content in liver	0.0	0.0	0.1	-0.1	-0.4	0.0	-0.3	0.1
Sr content in liver	0.2	0.2	0.7	0.0	-0.8	-0.5	-0.2	0.0
Zn content in liver	2.1	2.4	5.0	0.9	-1.1	0.2	-2.2	2.2