Hub : Genes

Dazap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	ENSRNOT00000101444	0.02	0.02	5.2e-03	0.01	0.01	0.01	0.01	7.3e-03	2.6e-02	1.4e-02	2.0e-02
2	Liver	intron excision ratio	chr7:9534236:9534487	0.06	0.04	3.6e-07	0.05	0.05	0.05	0.05	2.2e-06	1.3e-06	1.5e-06	1.8e-06
3	Liver	intron excision ratio	chr7:9535742:9535944	0.05	0.03	8.5e-06	0.03	0.04	0.04	0.04	1.9e-04	3.6e-05	4.5e-05	6.1e-05
4	NAcc	intron excision ratio	chr7:9536969:9538743	0.03	0.02	9.2e-03	0.02	0.01	0.02	0.01	1.7e-02	3.2e-02	2.0e-02	3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	7.1	22.8	23.9	-4.8	-4.9	4.9	4.5
BMI without tail	2.9	6.1	7.1	-2.7	-2.6	2.6	1.9
Body weight	1.3	5.4	5.9	-2.3	-2.4	2.4	2.1
Epididymis fat weight	0.2	0.4	0.6	0.1	0.8	-0.8	-0.7
Glucose	1.6	2.4	2.7	-1.5	-1.6	1.6	1.4
Heart weight	0.2	0.2	0.7	0.2	0.4	-0.4	-0.8
Left kidney weight	0.0	0.1	0.3	0.6	0.3	-0.3	-0.0
Right kidney weight	1.4	4.0	4.2	2.1	2.0	-2.0	-2.0
Tail length	2.9	8.8	10.2	2.7	3.0	-3.0	-3.2
Length with tail	2.0	7.4	8.3	2.9	2.7	-2.7	-2.5
Length without tail	0.2	0.4	0.9	0.9	0.6	-0.6	-0.0
Liver weight, left	2.6	4.3	5.5	-2.3	-2.0	2.0	1.9
Liver weight, right	1.7	2.8	3.2	-1.8	-1.5	1.5	1.8
Parametrial fat weight	0.3	0.6	1.0	0.7	0.7	-0.7	-1.0
Retroperitoneal fat weight	0.3	1.0	1.4	-1.2	-0.9	0.9	1.0
Intraocular pressure	0.2	0.3	0.5	-0.7	-0.4	0.4	-0.5
Extensor digitorum longus weight	5.2	21.0	22.5	-4.7	-4.7	4.7	4.1
Soleus weight	9.4	27.5	29.5	-4.9	-5.4	5.4	5.2
Tibialis anterior weight	1.2	4.3	4.4	-2.0	-2.1	2.1	2.1
Tibia length	0.9	2.4	2.9	1.5	1.5	-1.5	-1.7
Number of licking bursts	0.2	0.2	0.4	-0.6	-0.5	0.5	-0.2
Food consumed during 24 hour testing period	0.6	0.8	1.0	-0.8	-1.0	1.0	0.7
Times rat made contact with spout	0.4	0.4	0.6	-0.8	-0.7	0.7	0.3
Mean time between licks in bursts	3.9	5.5	6.5	2.1	2.4	-2.3	-2.6
Mean num. licks in bursts	0.0	0.0	0.1	0.0	-0.1	0.0	0.3
Std. dev. time between licks in bursts	0.9	1.1	2.0	1.4	0.9	-0.9	-0.8
Water consumed over 24 hours	0.5	0.6	1.0	-0.3	-0.8	0.8	1.0
Indifference point 0 sec	0.1	0.1	0.2	-0.2	-0.4	0.4	0.5
Indifference point AUC	0.7	0.9	1.2	0.7	0.9	-0.9	-1.1
Indifference point function ln k	0.3	0.4	0.5	-0.4	-0.7	0.7	0.6
Indifference point function log k	0.3	0.4	0.5	-0.4	-0.7	0.7	0.6
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	-0.2	-0.4	0.4	0.3
Delay discounting total patch changes 12 sec	0.5	0.7	1.3	-1.1	-0.8	0.8	0.4
Delay discounting total patch changes 18 sec	1.1	1.5	1.7	1.1	1.2	-1.2	-1.3
Delay discounting total patch changes 24 sec	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4
Delay discounting total patch changes 6 sec	0.2	0.4	0.4	0.7	0.6	-0.6	-0.6
Delay discounting time to switch 0 sec	0.7	1.1	2.9	-0.8	-0.7	0.7	1.7
Delay discounting water rate 0 sec	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.4
Delay discounting water rate 12 sec	1.7	2.6	3.3	-1.8	-1.8	1.8	0.8
Delay discounting water rate 18 sec	0.4	0.6	0.9	-1.0	-0.6	0.6	-0.8
Delay discounting water rate 24 sec	1.2	1.7	3.0	-1.7	-1.3	1.4	-0.0
Delay discounting water rate 6 sec	0.2	0.3	1.0	-0.2	-0.0	0.1	-1.0
Locomotor activity	3.9	6.2	8.5	2.9	2.5	-2.5	-2.1
Locomotor testing distance	2.3	3.8	4.9	2.2	1.9	-1.9	-1.7
Locomotor testing rearing	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.4
Light reinforcement 1	6.7	12.3	13.7	3.4	3.7	-3.7	-3.2
Light reinforcement 2	2.5	3.2	3.7	1.8	1.9	-1.9	-1.6
Reaction time number correct	0.9	1.3	1.7	-1.3	-1.3	1.3	0.5
Reaction time mean minus median	0.5	0.6	0.9	0.8	0.7	-0.7	-0.9
Reaction time mean minus median AUC	0.1	0.1	0.3	0.5	0.1	-0.1	0.3
Reaction time num false alarms	0.2	0.3	0.6	-0.4	-0.7	0.7	0.1
Reaction time num false alarms AUC	0.4	0.5	0.8	-0.7	-0.9	0.9	0.1
Reaction time trials correct on left	0.9	1.3	1.7	-1.3	-1.3	1.3	0.5
Reaction time trials on left	0.9	1.3	1.7	-1.3	-1.3	1.3	0.6
Reaction time mean	0.0	0.0	0.1	0.3	-0.1	0.1	0.2
Reaction time mean AUC	0.0	0.1	0.1	0.2	-0.2	0.2	0.3
Median of all reaction times	0.2	0.3	0.5	-0.2	-0.5	0.5	0.7
Reaction time omissions	0.3	0.4	0.5	0.7	0.6	-0.6	-0.5
Reaction time false alarm rate	0.0	0.0	0.1	-0.0	-0.3	0.3	0.1
Reaction time premature initiation rate	0.8	1.1	1.9	0.8	1.0	-1.0	-1.4
Reaction time premature initiations	0.3	0.4	1.4	0.2	0.4	-0.4	-1.2
Std. dev. reaction times	0.1	0.2	0.3	0.6	0.3	-0.3	-0.4
Reaction time trials completed	0.9	1.3	1.7	-1.3	-1.3	1.3	0.6
Reaction time trials AUC	0.9	1.3	1.8	-1.4	-1.3	1.3	0.5
Social response proportion	0.9	1.0	1.2	1.0	1.1	-1.1	-0.7
Social responses	7.5	9.7	11.1	3.3	3.1	-3.2	-2.8
Social time	0.5	0.7	0.9	-1.0	-0.7	0.7	0.8
Conditioned locomotion	2.0	2.4	3.3	-1.8	-1.6	1.6	1.0
Cocaine response after cond. corrected	6.8	7.6	8.9	-2.9	-2.9	3.0	2.1
Cocaine response after cond. not corrected	7.1	7.9	9.2	-3.0	-3.0	3.0	2.1
Cocaine response before conditioning	0.6	0.7	0.9	0.9	0.9	-0.9	-0.7
Saline control response	0.1	0.1	0.2	-0.4	-0.3	0.3	0.1
Condit. Reinf. active minus inactive responses	1.7	2.1	3.7	1.3	1.3	-1.3	-1.9
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	-0.4	-0.2	0.2	-0.6
Condit. Reinf. active responses	1.8	2.5	3.4	1.7	1.4	-1.4	-1.8
Condit. Reinf. inactive responses	1.1	1.4	2.2	1.5	1.1	-1.1	-1.1
Condit. Reinf. lever presses	1.9	2.6	3.8	1.4	1.5	-1.5	-2.0
Condit. Reinf. lever reinforcers received	1.2	1.7	2.8	1.3	1.1	-1.1	-1.7
Pavlov. Cond. lever latency	0.7	0.9	1.4	-1.2	-0.8	0.7	1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	0.7	-0.7	-0.7
Pavlov. Cond. change in total contacts	0.6	0.8	1.2	1.0	0.7	-0.7	-1.1
Pavlov. Cond. index score	0.7	0.9	1.3	1.1	0.8	-0.8	-1.1
Pavlov. Cond. latency score	0.7	0.9	1.4	1.2	0.8	-0.8	-1.0
Pavlov. Cond. lever contacts	0.5	0.7	1.2	0.9	0.7	-0.7	-1.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	-1.1	-0.9	0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	-0.9	-0.8	0.8	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	1.2	0.9	-0.8	-1.1
Pavlov. Cond. response bias	1.4	2.0	2.8	1.4	1.2	-1.2	-1.7
Conditioned reinforcement - actives	2.4	2.3	2.6	1.5	1.5	-1.5	-1.6
Conditioned reinforcement - inactives	0.6	0.7	1.1	-1.0	-0.8	0.8	0.6
Conditioned locomotion	7.1	8.6	8.9	2.8	3.0	-3.0	-3.0
Intermittent access intake day 1-15 change	6.5	6.5	7.6	2.4	2.5	-2.5	-2.8
Intermittent access intake escalation	5.4	5.4	8.1	1.9	2.2	-2.2	-2.8
Intermittent access intake escalation 2	6.7	6.6	9.7	2.1	2.5	-2.5	-3.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	0.0	0.1	-0.0	-0.6
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	0.5	0.7	-0.7	-0.8
Intermitt. access escalation Index	0.1	0.1	0.3	0.3	-0.2	0.2	0.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.2	0.2	0.3
Intermittent access day 15 total infusions	1.7	1.9	2.6	1.2	1.4	-1.3	-1.6
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.4	1.0	1.0	-1.0	-1.2
Intermittent access total infusions	0.2	0.2	0.3	0.3	0.4	-0.4	-0.5
Intermittent access day 1 locomotion	0.3	0.4	0.4	0.5	0.6	-0.6	-0.6
Intermittent access day 15 total locomotion	3.5	3.7	4.1	1.6	2.0	-2.0	-2.0
Intermittent access total locomotion	1.0	1.1	1.2	1.0	1.1	-1.1	-1.0
Intermittent access standard deviation	2.2	2.3	3.2	1.3	1.5	-1.5	-1.8
Cocaine induced anxiety	0.9	1.0	1.4	1.2	1.0	-1.0	-0.6
Post-drug Anxiety	0.7	0.8	1.1	1.0	1.0	-1.0	-0.3
Baseline Anxiety	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3
Lifetime Intake	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.0	0.1	-0.1	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.1	0.2	-0.2	-0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.5	-0.3	0.3	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.6	-0.4	0.4	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.1	0.2	-0.2	-0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.0	0.2	-0.2	-0.5
Progressive ratio test 2 breakpoint	0.1	0.2	0.2	0.3	0.4	-0.4	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.2	0.3	-0.3	-0.1
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	-0.1	0.1	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.1	0.4	-0.4	-0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Short access day 1 total infusions	0.3	0.3	0.5	0.7	0.6	-0.7	-0.2
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Short access total infusions	0.0	0.0	0.0	0.1	0.0	-0.0	0.1
Short access day 1 locomotion	1.3	1.3	1.8	1.4	1.2	-1.2	-0.9
Short access day 10 total locomotion	3.7	4.0	5.3	1.9	1.9	-1.9	-2.3
Short access total locomotion	1.0	1.0	1.2	1.1	0.9	-0.9	-1.0
Compulsive drug intake	1.1	1.1	1.5	-0.8	-1.1	1.0	1.2
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	-0.4	0.4	0.5
One hour access (shock baseline)	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.3
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.3	-0.3	-0.3
Context. condit. distance diff. score	0.3	0.3	0.4	-0.6	-0.5	0.5	0.6
Locomotion velocity, session 1	0.8	0.9	1.3	1.2	1.0	-1.0	-0.4
Locomotion distance, session 1	0.5	0.7	1.1	0.9	1.0	-1.0	0.2
Locomotion velocity, session 2	5.0	5.9	7.5	2.5	2.7	-2.7	-1.5
Locomotion distance, session 2	2.3	3.3	4.2	2.0	2.0	-2.1	-0.9
Locomotion velocity, session 3	6.1	7.1	7.6	2.5	2.8	-2.7	-2.7
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0
Stereotopy head waving bouts, day 3	5.6	6.7	7.8	2.5	2.8	-2.8	-2.2
Stereotopy head waving duration, day 3	6.3	7.6	8.6	2.6	2.9	-2.9	-2.5
Locomotion velocity, session 7	0.6	0.7	1.2	1.1	0.7	-0.7	-0.8
Locomotion distance, session 7	0.3	0.3	0.5	-0.6	-0.7	0.7	0.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	0.5	0.4	-0.4	0.3
Stereotopy head waving duration, day 7	0.5	0.6	1.0	1.0	0.8	-0.8	-0.1
Locomotion velocity, session 8	1.1	1.3	2.0	1.4	1.2	-1.3	-0.3
Locomotion distance, session 8	0.3	0.4	0.6	0.5	0.8	-0.8	-0.2
Degree of sensitization distance	0.4	0.4	0.4	-0.5	-0.7	0.7	0.6
Degree of sensitization stereotypy	1.5	1.6	2.7	-0.9	-1.2	1.2	1.6
Condit. Reinf. active minus inactive responses	4.6	5.1	5.8	2.1	2.4	-2.4	-2.1
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.7	1.2	1.4	-1.4	-1.6
Condit. Reinf. active responses	4.5	5.5	6.6	2.3	2.6	-2.6	-1.9
Condit. Reinf. inactive responses	1.4	1.6	2.1	1.4	1.4	-1.5	-0.6
Incentive salience index mean	2.8	3.4	4.2	1.8	2.0	-2.1	-1.4
Condit. Reinf. lever presses	0.3	0.4	0.6	0.8	0.6	-0.7	0.4
Time in familiar zone, hab. session 1	2.0	1.9	2.4	1.2	1.4	-1.4	-1.6
Time in novel zone, hab. session 1	0.8	0.8	1.4	-0.4	-0.9	0.9	1.2
Total zone transitions, hab. session 1	1.4	2.0	2.5	1.6	1.5	-1.6	-0.7
Total locomotion distance, hab. session 1	1.9	2.7	4.0	2.0	1.8	-1.8	-0.6
Locomotion velocity, hab. session 1	2.3	3.3	4.2	2.0	2.0	-2.1	-1.0
Time in familiar zone, hab. session 2	5.6	5.9	7.6	2.0	2.4	-2.4	-2.8
Time in novel zone, hab. session 2	4.2	4.2	5.7	-1.6	-2.1	2.1	2.4
Total zone transitions, hab. session 2	0.2	0.2	0.7	0.3	0.3	-0.4	0.8
Total locomotion distance, hab. session 2	1.5	2.0	2.9	1.4	1.7	-1.7	-0.7
Locomotion velocity, hab. session 2	1.6	2.2	3.1	1.5	1.7	-1.8	-0.6
Novel to familiar place preference ratio	3.4	3.6	5.5	-1.4	-1.9	1.9	2.3
Novelty place preference	2.0	2.1	3.4	-1.0	-1.4	1.4	1.9
Time in novel zone, NPP test	2.3	2.5	3.9	-1.1	-1.6	1.5	2.0
Total zone transitions, NPP test	0.1	0.2	0.3	0.3	0.5	-0.5	0.3
Total locomotion distance, NPP test	0.1	0.2	0.2	0.3	0.4	-0.4	0.5
Locomotion velocity, NPP test	0.2	0.3	0.5	0.6	0.7	-0.7	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4
Pavlov. Cond. magazine entry latency	3.2	4.1	4.8	1.7	2.2	-2.2	-2.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	0.5	-0.5	-0.2
Pavlov. Cond. index score	0.7	0.9	1.3	0.9	1.1	-1.1	-0.5
Pavlov. Cond. latency score	0.8	1.0	1.4	1.1	1.2	-1.2	-0.4
Pavlov. Cond. lever contacts	0.3	0.3	0.5	0.7	0.6	-0.6	0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.4	-0.8	-1.2	1.2	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	0.1	-0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.9	1.1	1.4	-1.4	-0.8
Pavlov. Cond. response bias	1.3	1.6	2.0	1.1	1.4	-1.4	-1.1
Bone: apparent density	0.3	0.4	1.1	1.1	0.3	-0.4	0.6
Bone surface	1.0	1.8	4.4	2.1	1.1	-1.2	0.3
Bone volume	1.0	1.7	4.5	2.1	1.0	-1.1	0.3
Bone: connectivity density	0.2	0.3	0.9	0.4	-0.1	0.1	1.0
Bone: cortical apparent density	0.8	1.1	1.3	-1.0	-1.1	1.1	1.0
Bone: cortical area	0.4	0.6	1.3	-0.1	-0.8	0.8	1.1
Bone: cortical porosity	0.7	0.8	1.2	1.1	0.9	-0.9	-0.6
Bone: cortical porosity	0.2	0.2	0.6	0.7	0.4	-0.4	0.1
Bone: cortical thickness	1.0	1.6	2.1	-0.9	-1.3	1.3	1.5
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3
Bone: cortical tissue density	0.6	0.8	0.9	-0.8	-0.9	0.9	0.8
Bone: elastic displacement	0.2	0.3	0.4	0.7	0.5	-0.5	-0.5
Bone: elastic work	0.2	0.3	0.4	-0.0	-0.6	0.6	0.6
Bone: endosteal estimation	0.1	0.3	0.6	-0.3	-0.5	0.5	0.8
Bone: endosteal perimeter	0.4	0.8	1.4	1.2	0.9	-0.9	-0.4
Bone: final force	1.1	1.8	2.6	-0.8	-1.4	1.4	1.6
Bone: final moment	0.8	1.4	2.1	-0.6	-1.3	1.2	1.4
Bone: marrow area	0.2	0.3	0.7	-0.3	-0.5	0.5	0.8
Bone: maximum diameter	1.0	1.8	3.0	1.7	1.3	-1.4	-0.8
Bone: maximum force	1.1	2.0	2.6	-0.9	-1.5	1.5	1.6
Bone: maximum moment	0.9	1.6	2.1	-0.8	-1.4	1.3	1.5
Bone: minimum diameter	0.0	0.1	0.2	0.4	0.0	-0.0	0.3
Bone: periosteal estimation	0.2	0.5	1.1	-0.0	-0.6	0.6	1.1
Bone: periosteal perimeter	0.2	0.3	0.9	1.0	0.4	-0.4	0.0
Bone: post-yield work	0.6	0.8	0.9	-0.9	-1.0	1.0	0.8
Bone: stiffness	2.8	4.4	5.5	-1.7	-2.2	2.1	2.3
Bone: tissue strength	1.6	1.6	1.8	-1.1	-1.3	1.3	1.4
Bone: trabecular number	1.0	1.6	2.7	1.6	1.3	-1.3	-0.6
Bone: trabecular spacing	1.2	1.6	3.0	-1.7	-1.3	1.3	0.1
Bone: trabecular thickness	0.7	0.9	2.5	1.6	0.5	-0.6	0.7
Bone: trabecular tissue density	1.9	2.7	3.5	-1.9	-1.6	1.6	1.4
Breakpoint value in progressive ratio session	5.1	5.7	7.1	2.1	2.4	-2.4	-2.7
Distance traveled before self-admin	0.4	0.4	0.6	-0.4	-0.7	0.6	0.8
Distance traveled after self-admin	0.7	0.7	0.9	0.9	0.9	-0.9	-0.8
Delta time in closed arm before/after self-admin	1.7	1.6	2.8	-1.7	-1.3	1.4	0.3
Delta time in open arm before/after self-admin	1.1	1.0	1.5	-0.9	-1.0	0.9	1.2
Diff in mean of infusions in LGA sessions	2.0	2.2	2.5	1.4	1.6	-1.6	-1.5
Extinction: sum of active levers before priming	0.9	0.9	1.7	0.5	0.9	-0.9	-1.3
Active lever presses in extinction session 6	2.9	2.8	3.0	1.7	1.7	-1.7	-1.7
Delta distance traveled before/after self-admin	1.9	2.0	2.1	1.4	1.5	-1.5	-1.4
Delta ambulatory time before/after self-admin	2.1	2.3	2.5	1.5	1.6	-1.6	-1.4
Time in closed arm before self-admin	0.4	0.4	1.3	-0.3	-0.5	0.4	1.1
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2
Time in open arm before self-admin	0.6	0.7	1.1	0.8	0.7	-0.7	-1.0
Time in open arm after self-admin	0.8	0.9	1.0	-0.9	-1.0	1.0	0.9
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.0	1.0	0.9	-0.9	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.6
Time to tail flick, test, before self-admin	0.5	0.5	0.9	1.0	0.6	-0.6	-0.3
Time to tail flick, test, after self-admin	0.4	0.4	0.5	0.7	0.7	-0.7	-0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.4	-1.2	-0.8	0.9	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.1	0.2	-0.2	-0.4
Ambulatory time before self-admin	0.4	0.4	0.5	-0.4	-0.6	0.6	0.7
Ambulatory time after self-admin	0.4	0.4	0.5	0.7	0.6	-0.6	-0.5
Total heroin consumption	2.0	2.5	2.6	1.5	1.6	-1.6	-1.5
Area under the delay curve	2.2	2.4	2.7	-1.2	-1.6	1.6	1.7
Delay disc. indifference point, 0s delay	5.5	6.0	9.5	-2.0	-2.3	2.3	3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.2	-0.3	0.3	0.5
Delay disc. indifference point, 2s delay	5.3	5.9	7.3	-2.1	-2.4	2.4	2.7
Delay disc. indifference point, 24s delay	0.9	0.9	1.1	-0.8	-1.0	1.1	0.8
Delay disc. indifference point, 4s delay	0.9	0.9	1.7	-0.6	-0.9	0.9	1.3
Delay disc. indifference point, 8s delay	1.5	1.6	2.0	-1.2	-1.4	1.4	1.0
Delay discount exponential model param	2.1	2.2	2.5	1.2	1.6	-1.6	-1.6
Delay discount hyperbolic model param	2.9	3.1	3.5	1.4	1.9	-1.8	-1.9
Fecal boli incidents, locomotor time 1	2.0	2.2	3.1	-1.8	-1.5	1.5	1.1
Change in fecal boli incidents, locomotor task	0.4	0.3	1.0	1.0	0.3	-0.3	-0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	-0.1	-0.6	0.6	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.3	0.4	-0.4	-0.5
Total resting periods, locomotor time 1	0.2	0.3	0.3	0.5	0.5	-0.5	-0.5
Rest time, locomotor task time 1	0.3	0.4	0.5	0.5	0.7	-0.7	-0.4
Distance moved, locomotor task time 1	0.4	0.4	0.8	-0.1	-0.7	0.6	0.9
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.3	-0.7	0.8	0.1
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.4	-1.3	-1.5	1.5	1.0
Bouts of movement, locomotor time 2	0.7	0.8	1.1	1.0	1.0	-1.1	-0.3
Total resting periods, locomotor time 2	0.7	0.7	1.0	1.0	1.0	-1.0	-0.2
Rest time, locomotor task time 2	0.8	0.9	1.2	1.1	1.0	-1.0	-0.6
Distance moved, locomotor task time 2	0.9	1.1	1.4	-1.2	-1.0	1.0	0.8
Vertical activity count, locomotor time 2	1.1	1.2	1.8	-1.3	-1.2	1.2	0.5
Weight adjusted by age	0.7	0.7	1.0	-0.9	-1.0	1.0	0.3
Seeking ratio, delayed vs. immediate footshock	4.8	5.5	6.2	2.5	2.4	-2.4	-2.1
Locomotion in novel chamber	0.1	0.2	0.5	0.1	0.3	-0.2	-0.7
Locomotion in novel chamber post-restriction	0.8	1.0	1.3	0.9	0.9	-0.9	-1.2
Progressive ratio	0.3	0.4	0.9	-1.0	-0.4	0.4	0.5
Food seeking constrained by brief footshock	0.3	0.4	0.7	0.2	0.8	-0.8	-0.4
Seeking ratio, punishment vs. effort	0.4	0.4	0.6	0.7	0.7	-0.7	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.5	0.7	0.7	-0.7	-0.5
Run reversals in cocaine runway, males	1.8	1.7	2.0	1.3	1.4	-1.4	-1.1
Latency to leave start box in cocaine runway	1.0	1.1	2.3	1.5	1.0	-1.0	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.7	0.1	-0.1	0.5
Latency to leave start box in cocaine runway, M	2.1	2.0	3.0	1.2	1.4	-1.3	-1.7
Cd content in liver	0.2	0.2	0.3	-0.3	-0.6	0.5	0.5
Co content in liver	0.5	0.6	0.8	0.6	0.7	-0.7	-0.9
Cu content in liver	0.1	0.1	0.3	0.2	-0.1	0.1	0.6
Fe content in liver	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3
K content in liver	0.1	0.1	0.2	0.4	0.2	-0.3	0.3
Mg content in liver	0.1	0.1	0.2	0.5	0.2	-0.2	0.4
Mn content in liver	1.8	2.1	3.9	2.0	1.5	-1.5	-0.5
Na content in liver	0.6	0.6	1.5	-0.5	-0.6	0.6	1.2
Rb content in liver	0.2	0.3	0.9	-0.0	-0.4	0.3	0.9
Se content in liver	0.3	0.3	0.4	0.5	0.6	-0.7	-0.4
Sr content in liver	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.3
Zn content in liver	1.2	1.3	3.2	0.5	1.0	-0.9	-1.8