Hub : Genes

Lmf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000030633 0.69 0.07 0.0e+00 0.62 0.62 0.63 0.63 1.9e-88 5.1e-89 9.2e-90 1.1e-89
2 Adipose mRNA stability ENSRNOG00000030633 0.11 0.07 8.5e-07 0.01 0.04 0.04 0.04 7.3e-03 1.9e-05 1.1e-05 3.0e-05
3 BLA gene expression ENSRNOG00000030633 0.28 0.11 1.6e-12 0.15 0.2 0.2 0.21 1.6e-08 5.0e-11 8.6e-11 2.6e-11
4 Brain gene expression ENSRNOG00000030633 0.48 0.11 0.0e+00 0.44 0.54 0.53 0.53 5.0e-44 3.7e-58 1.8e-57 1.5e-57
5 Eye gene expression ENSRNOG00000030633 0.5 0.17 1.3e-04 0.04 0.06 0.08 0.06 7.4e-02 4.8e-02 2.5e-02 4.8e-02
6 IL gene expression ENSRNOG00000030633 0.3 0.13 1.2e-04 0.11 0.17 0.16 0.13 1.6e-03 6.0e-05 1.5e-04 5.4e-04
7 LHb gene expression ENSRNOG00000030633 0.47 0.13 1.6e-10 0.32 0.36 0.31 0.32 2.5e-08 2.0e-09 5.1e-08 1.8e-08
8 Liver gene expression ENSRNOG00000030633 0.26 0.09 0.0e+00 0.18 0.18 0.19 0.19 1.5e-19 8.5e-20 6.7e-21 8.0e-21
9 Liver mRNA stability ENSRNOG00000030633 0.02 0.02 6.2e-03 0.01 0.01 0.01 0.01 3.5e-02 8.7e-03 1.4e-02 1.3e-02
10 NAcc gene expression ENSRNOG00000030633 0.35 0.13 0.0e+00 0.24 0.26 0.26 0.26 1.1e-17 1.1e-19 1.6e-19 4.4e-19
11 OFC gene expression ENSRNOG00000030633 0.44 0.13 3.7e-07 0.23 0.23 0.21 0.22 3.6e-06 2.6e-06 8.0e-06 4.7e-06
12 PL gene expression ENSRNOG00000030633 0.37 0.14 2.8e-16 0.1 0.21 0.19 0.21 5.1e-08 4.8e-16 1.1e-14 3.2e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail4.113.220.8-4.2-2.6-2.5-4.3-2.7-4.0-4.6-0.4-3.7-4.3-3.7-4.3
BMI without tail2.34.88.9-3.0-0.9-1.0-2.6-1.3-2.2-2.8-0.8-2.5-2.7-2.1-2.8
Body weight2.39.613.3-3.4-2.8-2.6-3.5-2.7-3.4-3.6-0.1-3.0-3.5-3.2-3.4
Epididymis fat weight2.04.69.2-2.2-2.1-1.8-2.4-1.3-2.4-1.81.3-1.6-2.4-3.0-2.6
Glucose0.20.31.00.90.50.10.50.0-0.00.51.01.00.50.10.3
Heart weight1.11.62.90.71.11.51.21.41.71.2-1.30.41.21.51.3
Left kidney weight3.911.115.3-3.9-3.5-3.3-3.7-3.1-3.0-3.7-1.0-3.7-3.7-2.9-3.5
Right kidney weight7.320.727.1-5.2-4.5-4.2-5.1-4.3-4.4-5.2-0.9-4.9-5.1-4.3-4.8
Tail length0.30.91.71.00.80.81.10.71.01.30.21.11.10.91.0
Length with tail0.10.30.90.4-0.7-1.00.1-0.7-0.30.30.90.40.1-0.40.1
Length without tail0.71.63.6-0.7-1.8-1.9-1.1-1.6-1.3-1.10.3-1.0-1.1-1.2-0.9
Liver weight, left0.10.20.90.40.3-0.2-0.0-0.6-0.6-0.11.00.4-0.0-0.4-0.0
Liver weight, right0.50.95.01.20.6-0.30.3-0.1-0.50.72.21.40.4-0.70.3
Parametrial fat weight0.10.10.7-0.20.40.20.0-0.30.1-0.4-0.9-0.50.00.40.1
Retroperitoneal fat weight1.34.36.8-2.3-1.6-1.5-2.4-1.7-2.4-2.40.5-1.8-2.4-2.2-2.6
Intraocular pressure0.20.41.30.10.40.4-0.40.9-0.6-0.21.10.4-0.3-0.7-0.7
Extensor digitorum longus weight0.20.81.6-1.2-1.1-0.0-1.0-0.4-0.7-1.2-0.7-1.2-1.0-0.6-0.9
Soleus weight0.61.63.0-1.7-1.0-0.7-1.5-1.0-1.1-1.7-0.9-1.7-1.4-0.9-1.3
Tibialis anterior weight0.00.10.2-0.3-0.50.5-0.10.50.1-0.1-0.3-0.2-0.10.0-0.1
Tibia length1.13.16.42.51.90.62.10.31.41.80.31.92.21.72.4
Number of licking bursts0.10.20.7-0.00.00.80.20.80.50.3-0.40.10.20.40.2
Food consumed during 24 hour testing period1.92.33.6-1.9-1.2-1.4-1.7-1.2-1.4-1.9-0.7-1.8-1.7-1.3-1.6
Times rat made contact with spout0.91.05.9-0.6-0.4-0.4-0.0-1.00.5-0.8-2.4-1.5-0.10.90.5
Mean time between licks in bursts4.05.610.91.82.13.32.42.92.62.4-0.71.92.42.62.2
Mean num. licks in bursts0.30.41.90.0-0.2-1.20.0-1.4-0.1-0.5-0.8-0.6-0.00.20.3
Std. dev. time between licks in bursts1.62.03.6-1.1-1.0-1.2-1.5-1.6-1.9-1.70.7-0.8-1.5-1.5-1.7
Water consumed over 24 hours0.70.82.5-0.6-0.8-1.4-0.7-1.6-0.9-1.0-0.3-0.8-0.7-0.6-0.6
Indifference point 0 sec0.40.71.3-0.7-1.1-1.1-0.8-0.9-0.8-0.90.2-0.7-0.8-0.8-0.7
Indifference point AUC1.01.27.10.30.1-0.6-0.4-0.5-1.4-0.02.71.1-0.4-1.3-0.9
Indifference point function ln k1.62.34.6-1.6-1.7-1.5-1.4-1.7-1.0-1.8-1.5-2.1-1.4-0.8-0.9
Indifference point function log k1.62.34.6-1.6-1.7-1.5-1.4-1.7-1.0-1.8-1.5-2.1-1.4-0.8-0.9
Delay discounting total patch changes 0 sec0.20.30.8-0.4-0.8-0.9-0.5-0.6-0.5-0.50.1-0.5-0.5-0.5-0.4
Delay discounting total patch changes 12 sec0.60.83.8-0.2-0.4-0.8-0.7-0.5-1.2-0.31.90.3-0.6-1.4-0.9
Delay discounting total patch changes 18 sec0.81.13.91.31.00.30.80.80.11.12.01.70.8-0.00.5
Delay discounting total patch changes 24 sec0.30.41.80.60.20.10.30.80.10.71.30.80.3-0.40.2
Delay discounting total patch changes 6 sec0.50.82.9-0.1-0.4-1.1-0.6-1.0-1.2-0.41.70.3-0.6-1.1-0.9
Delay discounting time to switch 0 sec0.60.91.30.71.10.91.01.11.11.1-0.20.71.00.91.0
Delay discounting water rate 0 sec0.81.22.2-1.0-1.4-0.8-1.0-1.5-0.9-1.4-0.9-1.4-1.0-0.5-0.8
Delay discounting water rate 12 sec2.33.46.1-1.6-2.5-2.1-1.8-2.1-1.8-2.2-0.7-2.0-1.9-1.4-1.5
Delay discounting water rate 18 sec2.93.97.1-2.0-2.6-1.9-1.8-2.3-1.3-2.3-1.9-2.7-1.9-1.0-1.3
Delay discounting water rate 24 sec1.11.52.6-1.2-1.6-1.1-1.0-1.5-0.7-1.4-1.5-1.6-1.1-0.3-0.7
Delay discounting water rate 6 sec0.71.02.1-0.9-1.5-0.9-0.9-1.3-0.8-1.3-0.9-1.3-0.9-0.4-0.7
Locomotor activity1.11.72.9-0.7-1.5-1.5-1.3-0.9-1.7-1.01.4-0.2-1.3-1.7-1.5
Locomotor testing distance0.30.50.90.90.40.50.70.90.60.80.30.90.70.70.5
Locomotor testing rearing0.81.35.70.5-0.8-1.1-0.6-0.7-1.5-0.22.41.0-0.6-1.4-1.0
Light reinforcement 10.91.73.1-0.9-1.3-1.7-1.3-1.2-1.5-1.01.1-0.6-1.3-1.7-1.4
Light reinforcement 24.56.08.7-1.8-2.7-2.9-2.7-2.5-2.9-2.41.5-1.5-2.6-2.9-2.5
Reaction time number correct0.60.91.21.00.91.01.10.81.00.90.00.91.01.10.9
Reaction time mean minus median0.10.10.3-0.4-0.2-0.0-0.40.2-0.4-0.20.2-0.1-0.4-0.4-0.5
Reaction time mean minus median AUC0.10.10.3-0.5-0.6-0.3-0.4-0.2-0.3-0.3-0.2-0.4-0.4-0.3-0.4
Reaction time num false alarms0.10.20.80.20.20.50.20.90.40.60.50.40.20.00.0
Reaction time num false alarms AUC0.20.31.00.10.60.80.41.00.70.5-0.20.20.30.50.3
Reaction time trials correct on left0.60.91.21.00.91.01.10.81.00.90.00.91.01.10.9
Reaction time trials on left0.71.01.41.11.01.11.10.91.00.9-0.00.91.11.21.0
Reaction time mean0.91.22.40.40.91.60.91.31.40.8-1.40.11.01.31.1
Reaction time mean AUC1.01.32.70.51.01.61.01.41.40.9-1.30.31.11.31.1
Median of all reaction times1.72.34.20.61.22.01.31.62.01.1-2.10.11.41.91.6
Reaction time omissions1.62.14.70.91.61.81.32.21.71.5-0.61.11.41.51.2
Reaction time false alarm rate0.00.10.3-0.30.00.2-0.20.50.10.10.1-0.1-0.1-0.2-0.2
Reaction time premature initiation rate5.16.811.3-2.2-2.3-2.7-2.8-2.4-3.2-2.41.9-1.5-2.8-3.4-3.1
Reaction time premature initiations2.02.84.7-1.3-1.4-1.6-1.7-1.6-2.1-1.61.5-0.8-1.8-2.2-2.1
Std. dev. reaction times0.10.20.6-0.20.30.80.00.70.3-0.0-0.8-0.20.10.40.0
Reaction time trials completed0.71.01.41.11.01.11.10.91.00.9-0.00.91.11.21.0
Reaction time trials AUC0.50.71.00.90.90.90.90.70.90.7-0.10.70.91.00.8
Social response proportion0.20.30.60.60.80.50.40.70.30.50.50.70.40.10.2
Social responses0.10.10.60.40.4-0.00.10.5-0.10.30.80.60.2-0.3-0.2
Social time0.30.32.3-0.40.30.30.00.10.4-0.4-1.5-0.80.10.70.1
Conditioned locomotion0.30.31.0-1.0-0.50.1-0.70.2-0.3-0.7-0.4-0.8-0.6-0.3-0.8
Cocaine response after cond. corrected1.21.42.1-1.4-1.1-1.2-1.3-1.0-1.0-1.3-0.4-1.4-1.3-1.1-1.2
Cocaine response after cond. not corrected2.62.84.6-2.2-1.5-1.4-1.9-1.4-1.4-2.0-0.8-2.1-1.9-1.4-1.8
Cocaine response before conditioning0.70.81.4-1.2-0.8-0.4-1.1-0.4-0.8-1.2-0.5-1.1-1.1-0.7-1.1
Saline control response2.02.74.4-1.4-1.7-1.4-1.9-1.3-2.1-1.70.9-0.9-1.9-2.0-2.1
Condit. Reinf. active minus inactive responses0.50.62.70.6-0.6-0.9-0.3-0.7-1.0-0.01.70.5-0.2-1.1-0.2
Condit. Reinf. active-inactive response ratio0.10.10.40.40.2-0.10.00.4-0.20.20.60.40.1-0.30.1
Condit. Reinf. active responses0.91.32.8-0.1-1.1-1.1-1.0-1.1-1.6-0.91.6-0.0-1.0-1.7-1.0
Condit. Reinf. inactive responses0.81.11.9-0.7-1.0-0.6-1.1-1.1-1.4-1.30.6-0.6-1.1-1.2-1.2
Condit. Reinf. lever presses1.52.13.6-1.1-1.0-1.4-1.6-1.2-1.9-1.51.0-0.9-1.6-1.9-1.7
Condit. Reinf. lever reinforcers received0.91.23.0-0.1-1.0-1.1-0.9-1.0-1.6-0.81.70.0-0.9-1.7-1.0
Pavlov. Cond. lever latency1.01.42.01.30.61.21.31.01.11.40.31.41.31.21.2
Pavlov. Cond. magazine entry latency0.20.30.5-0.70.3-0.2-0.6-0.2-0.5-0.6-0.2-0.7-0.6-0.6-0.5
Pavlov. Cond. change in total contacts0.30.41.1-0.10.0-0.7-0.6-0.7-1.0-0.60.9-0.2-0.6-1.0-0.6
Pavlov. Cond. index score0.81.11.6-1.0-0.2-1.1-1.1-1.1-1.2-1.3-0.0-1.1-1.1-1.2-1.0
Pavlov. Cond. latency score1.11.42.0-1.2-0.5-1.3-1.3-1.2-1.3-1.4-0.2-1.3-1.3-1.3-1.2
Pavlov. Cond. lever contacts1.01.42.0-1.3-0.6-1.3-1.3-1.1-1.2-1.4-0.2-1.3-1.3-1.2-1.3
Pavlov. Cond. magazine entry number0.40.40.80.7-0.30.30.80.40.80.90.10.70.80.80.7
Pavlov. Cond. intertrial magazine entries0.20.31.5-0.0-0.8-1.00.1-1.20.1-0.1-0.6-0.30.00.30.2
Pavlov. Cond. lever-magazine prob. diff.0.70.91.4-1.0-0.2-1.0-1.1-1.0-1.1-1.2-0.0-1.0-1.1-1.1-1.0
Pavlov. Cond. response bias0.40.60.9-0.80.0-0.8-0.9-0.6-0.8-0.90.1-0.8-0.9-0.9-0.9
Conditioned reinforcement - actives0.50.50.8-0.7-0.8-0.5-0.9-0.5-0.8-0.80.3-0.6-0.8-0.8-0.8
Conditioned reinforcement - inactives0.20.30.5-0.7-0.4-0.3-0.6-0.2-0.3-0.7-0.6-0.7-0.5-0.2-0.5
Conditioned locomotion3.44.15.9-2.1-2.1-1.8-2.3-1.8-2.2-2.4-0.1-2.0-2.2-1.9-2.2
Intermittent access intake day 1-15 change0.70.71.6-0.8-0.9-1.0-0.8-1.3-0.7-1.0-0.4-1.0-0.8-0.7-0.6
Intermittent access intake escalation1.11.12.0-1.0-1.2-1.1-1.0-1.4-1.0-1.2-0.2-1.1-1.0-1.0-0.9
Intermittent access intake escalation 23.83.86.0-1.7-2.5-2.2-2.0-2.4-2.0-1.80.5-1.7-2.0-2.1-1.8
Intermitt. access day 1 inactive lever presses2.12.23.5-1.3-1.5-1.7-1.5-1.9-1.7-1.60.5-1.1-1.5-1.6-1.5
Intermitt. access day 15 inactive lever presses3.13.45.9-2.2-1.8-1.8-1.9-1.9-1.4-2.3-1.4-2.4-1.9-1.1-1.5
Intermitt. access escalation Index0.80.71.30.80.90.31.00.91.11.0-0.30.61.00.91.1
Intermittent access day 1 total infusions0.00.00.2-0.10.2-0.1-0.10.00.1-0.3-0.4-0.3-0.00.20.0
Intermittent access day 15 total infusions0.20.20.5-0.4-0.4-0.5-0.4-0.7-0.3-0.6-0.4-0.7-0.4-0.2-0.2
Intermittent access terminal intake (last 3 days)2.83.04.1-1.7-1.8-1.8-1.9-2.0-1.8-2.0-0.2-1.8-1.8-1.7-1.6
Intermittent access total infusions0.30.30.6-0.5-0.5-0.6-0.7-0.7-0.6-0.8-0.1-0.6-0.6-0.5-0.5
Intermittent access day 1 locomotion0.00.00.1-0.2-0.0-0.3-0.2-0.2-0.2-0.3-0.2-0.3-0.2-0.1-0.2
Intermittent access day 15 total locomotion0.40.40.9-0.6-0.3-0.6-0.7-0.6-0.7-0.9-0.2-0.6-0.7-0.5-0.7
Intermittent access total locomotion0.40.41.0-0.8-0.4-0.5-0.6-0.7-0.4-1.0-0.8-1.0-0.6-0.1-0.5
Intermittent access standard deviation0.60.61.8-0.9-0.9-0.5-0.5-0.8-0.1-0.8-1.4-1.3-0.50.1-0.1
Cocaine induced anxiety2.62.95.1-2.0-1.8-1.6-1.9-1.5-1.3-2.1-1.3-2.3-1.8-1.2-1.4
Post-drug Anxiety3.23.54.6-1.9-2.0-2.1-2.1-2.0-1.8-2.1-0.4-2.0-2.0-1.7-1.7
Baseline Anxiety0.50.51.30.90.60.30.70.30.31.01.11.10.70.10.5
Lifetime Intake0.20.20.5-0.5-0.2-0.3-0.5-0.4-0.3-0.7-0.5-0.7-0.4-0.2-0.3
Incentive Sensitization - Responses0.80.81.5-0.7-0.5-0.6-1.0-0.7-1.2-0.80.7-0.5-1.0-1.2-1.1
Incentive Sensitization - Breakpoint0.60.61.1-0.7-0.3-0.4-0.9-0.6-1.0-0.70.6-0.4-0.8-1.1-1.0
Progressive ratio test 1 active lever presses0.40.43.0-0.40.30.10.10.00.7-0.2-1.7-0.80.20.80.4
Progressive ratio test 1 breakpoint0.40.43.0-0.50.20.00.0-0.10.6-0.3-1.7-0.90.10.70.3
Progressive ratio test 1 inactive lever presses0.10.20.6-0.5-0.3-0.3-0.3-0.10.0-0.4-0.8-0.7-0.20.0-0.1
Progressive ratio test 2 active lever presses0.40.40.6-0.7-0.3-0.4-0.7-0.7-0.7-0.8-0.1-0.7-0.7-0.6-0.7
Progressive ratio test 2 breakpoint0.30.30.5-0.6-0.2-0.4-0.7-0.6-0.6-0.7-0.0-0.6-0.6-0.6-0.7
Progressive ratio test 2 inactive lever presses0.40.50.9-0.7-0.2-0.7-0.8-0.7-0.8-1.0-0.1-0.7-0.7-0.6-0.8
Total sessions with >9 infusions0.20.30.8-0.60.10.0-0.6-0.1-0.4-0.9-0.6-0.7-0.5-0.1-0.6
Short access day 1 total inactive lever presses2.12.35.4-2.2-1.0-0.4-1.7-0.6-0.8-2.1-1.9-2.3-1.5-0.5-1.3
Short access day 10 total inactive lever presses10.611.714.1-3.4-3.8-3.5-3.7-3.7-3.7-3.60.4-3.1-3.7-3.6-3.5
Short access day 1 total infusions0.40.41.9-0.70.20.2-0.40.1-0.0-0.9-1.4-1.0-0.30.3-0.3
Short access day 10 total infusions0.70.71.6-1.0-0.6-0.7-0.9-0.7-0.6-1.2-0.9-1.2-0.8-0.5-0.7
Short access total infusions0.30.31.1-0.60.0-0.1-0.4-0.2-0.1-0.8-1.1-0.9-0.30.1-0.3
Short access day 1 locomotion0.40.41.4-0.8-0.3-0.5-0.4-0.7-0.1-0.8-1.2-1.0-0.40.1-0.2
Short access day 10 total locomotion2.32.54.6-2.0-1.4-1.1-1.7-1.4-1.2-2.1-1.4-2.2-1.6-0.9-1.4
Short access total locomotion0.60.71.4-1.0-0.5-0.6-0.8-0.6-0.5-1.1-1.1-1.2-0.7-0.2-0.6
Compulsive drug intake0.30.30.70.80.1-0.20.50.20.20.80.80.80.5-0.00.4
One hour access (0.3 mA shock)1.51.73.8-0.6-1.5-1.9-1.1-1.9-1.5-1.01.1-0.6-1.1-1.6-1.1
One hour access (shock baseline)1.72.03.0-1.0-1.5-1.6-1.5-1.7-1.7-1.40.7-1.0-1.4-1.6-1.4
Number of responses in last shaping day0.30.31.10.00.91.10.40.30.4-0.0-0.8-0.00.30.70.3
Context. condit. distance diff. score0.70.92.1-1.40.1-0.2-1.0-0.6-0.5-1.4-1.2-1.5-1.0-0.3-0.9
Locomotion velocity, session 10.10.10.4-0.40.10.5-0.30.5-0.2-0.4-0.1-0.1-0.4-0.1-0.6
Locomotion distance, session 11.82.33.91.82.01.51.61.41.11.50.81.91.61.31.2
Locomotion velocity, session 20.70.81.7-1.2-0.6-0.1-1.1-0.1-0.9-1.00.1-0.8-1.1-1.0-1.3
Locomotion distance, session 20.71.02.31.11.50.91.10.70.71.10.61.31.10.80.8
Locomotion velocity, session 30.40.52.9-0.50.00.20.30.01.00.1-1.7-0.80.30.90.5
Locomotion distance, session 30.40.41.10.20.70.80.51.00.80.5-0.40.20.50.60.4
Stereotopy head waving bouts, day 31.21.42.81.31.01.11.11.30.81.61.31.71.10.50.9
Stereotopy head waving duration, day 30.70.81.30.90.81.00.91.00.91.20.30.90.90.70.9
Locomotion velocity, session 70.30.31.8-0.60.00.3-0.10.50.5-0.2-1.3-1.0-0.10.20.1
Locomotion distance, session 70.10.20.8-0.30.70.0-0.00.10.1-0.4-0.9-0.6-0.10.20.0
Stereotopy head waving bouts, day 70.10.10.50.2-0.6-0.00.30.00.40.70.30.50.30.20.3
Stereotopy head waving duration, day 70.60.81.90.6-0.20.80.91.01.21.4-0.00.81.00.90.9
Locomotion velocity, session 80.70.82.5-1.6-0.7-0.4-1.0-0.1-0.3-0.8-0.7-1.3-1.0-0.8-1.1
Locomotion distance, session 80.50.81.5-1.10.1-0.5-1.0-0.9-1.0-1.20.0-0.8-1.0-0.8-1.2
Degree of sensitization distance1.91.92.7-1.2-1.0-1.6-1.5-1.6-1.6-1.60.2-1.2-1.5-1.5-1.4
Degree of sensitization stereotypy0.10.10.4-0.1-0.70.10.3-0.00.50.5-0.50.00.30.40.3
Condit. Reinf. active minus inactive responses1.51.63.1-1.5-1.4-0.5-1.60.0-1.3-1.10.7-0.9-1.6-1.7-1.8
Condit. Reinf. active-inactive response ratio0.20.20.9-0.6-0.10.6-0.41.0-0.1-0.10.2-0.1-0.4-0.4-0.6
Condit. Reinf. active responses2.12.64.5-1.9-1.9-0.7-2.0-0.3-1.6-1.60.4-1.3-1.9-2.0-2.1
Condit. Reinf. inactive responses1.51.82.7-1.4-1.6-0.9-1.6-0.8-1.5-1.50.1-1.2-1.6-1.5-1.7
Incentive salience index mean2.63.15.4-1.9-1.9-1.0-2.2-0.5-2.0-1.71.0-1.2-2.1-2.3-2.3
Condit. Reinf. lever presses2.33.15.1-1.9-1.8-1.1-2.1-0.8-2.0-1.70.8-1.3-2.1-2.2-2.3
Time in familiar zone, hab. session 10.30.21.6-0.5-0.2-0.0-0.1-0.20.3-0.4-1.3-0.7-0.10.50.0
Time in novel zone, hab. session 10.40.41.50.70.60.50.40.70.10.81.21.10.4-0.10.1
Total zone transitions, hab. session 11.72.44.32.11.91.01.80.51.11.60.92.01.81.41.6
Total locomotion distance, hab. session 10.20.31.20.4-0.0-0.6-0.0-1.1-0.7-0.20.90.6-0.0-0.2-0.2
Locomotion velocity, hab. session 10.30.41.40.60.1-0.60.1-1.1-0.7-0.11.20.70.1-0.3-0.1
Time in familiar zone, hab. session 20.80.92.3-1.3-0.8-0.5-0.9-0.1-0.3-1.1-1.3-1.5-0.9-0.4-0.7
Time in novel zone, hab. session 21.31.32.61.30.91.11.21.00.91.50.91.61.20.90.9
Total zone transitions, hab. session 20.10.10.3-0.10.40.20.0-0.4-0.0-0.4-0.5-0.30.10.30.0
Total locomotion distance, hab. session 20.91.22.2-1.0-0.7-0.9-1.1-1.5-1.3-1.5-0.2-1.0-1.1-0.8-1.2
Locomotion velocity, hab. session 20.91.32.7-1.0-0.7-1.0-1.2-1.6-1.4-1.5-0.0-0.9-1.2-0.9-1.2
Novel to familiar place preference ratio0.80.81.90.20.61.10.91.31.41.0-0.90.20.81.00.8
Novelty place preference0.60.61.6-0.10.31.00.61.21.30.8-1.0-0.00.60.90.6
Time in novel zone, NPP test0.90.92.20.00.51.20.81.31.50.9-1.20.00.71.20.8
Total zone transitions, NPP test0.71.02.51.11.60.81.10.30.80.90.01.01.21.11.0
Total locomotion distance, NPP test0.10.20.5-0.00.2-0.4-0.3-0.6-0.7-0.40.70.2-0.3-0.3-0.5
Locomotion velocity, NPP test0.20.30.6-0.10.0-0.5-0.4-0.8-0.8-0.50.70.1-0.4-0.5-0.6
Pavlov. Cond. lever latency0.91.22.21.30.60.31.40.31.31.2-0.50.91.41.41.5
Pavlov. Cond. magazine entry latency0.50.62.00.51.11.20.61.40.70.80.20.70.60.30.5
Pavlov. Cond. change in total contacts0.40.51.9-0.10.61.1-0.31.4-0.20.11.00.4-0.2-0.7-0.6
Pavlov. Cond. index score0.10.20.7-0.20.40.6-0.30.8-0.1-0.00.40.0-0.2-0.5-0.3
Pavlov. Cond. latency score0.20.20.6-0.50.10.3-0.50.5-0.4-0.30.5-0.2-0.5-0.7-0.6
Pavlov. Cond. lever contacts1.41.63.2-1.6-0.8-0.3-1.6-0.1-1.4-1.40.5-1.1-1.6-1.7-1.8
Pavlov. Cond. magazine entry number0.30.41.3-0.5-0.9-0.7-0.4-1.1-0.4-0.6-0.6-0.6-0.40.0-0.2
Pavlov. Cond. intertrial magazine entries1.61.92.8-1.3-1.5-1.1-1.6-1.1-1.6-1.50.6-1.0-1.6-1.6-1.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.9-0.10.50.7-0.21.0-0.10.10.50.1-0.1-0.4-0.2
Pavlov. Cond. response bias0.20.20.5-0.50.10.2-0.60.6-0.4-0.40.4-0.2-0.5-0.7-0.7
Bone: apparent density0.50.81.80.80.60.70.81.10.71.31.01.30.80.40.4
Bone surface0.30.63.60.7-0.5-0.00.20.3-0.20.91.91.30.2-0.5-0.2
Bone volume0.50.82.71.0-0.10.40.70.70.31.31.61.50.7-0.00.3
Bone: connectivity density0.30.51.50.40.50.80.61.20.71.20.71.00.60.30.2
Bone: cortical apparent density3.24.25.42.01.82.32.22.02.22.2-0.31.82.32.22.3
Bone: cortical area0.50.71.7-0.4-0.6-0.2-0.9-0.6-1.3-0.91.0-0.2-0.9-1.2-1.0
Bone: cortical porosity1.11.22.3-0.6-0.9-1.0-1.1-0.8-1.5-0.91.3-0.2-1.1-1.5-1.4
Bone: cortical porosity2.32.44.3-1.1-1.6-1.4-1.7-1.4-2.1-1.51.3-0.6-1.7-1.9-2.0
Bone: cortical thickness0.10.10.90.40.40.90.20.2-0.00.00.10.30.30.20.3
Bone: cortical thickness0.30.31.50.10.91.20.10.70.3-0.3-0.7-0.30.20.50.5
Bone: cortical tissue density3.03.84.91.91.72.22.21.92.22.1-0.41.72.22.12.2
Bone: elastic displacement0.10.10.20.2-0.1-0.30.3-0.20.20.30.20.40.20.20.1
Bone: elastic work0.40.50.9-0.7-0.5-0.4-0.8-0.8-0.9-0.90.2-0.5-0.8-0.7-0.9
Bone: endosteal estimation0.40.81.5-0.6-0.9-0.8-1.0-0.7-1.2-0.90.9-0.3-1.0-1.2-1.1
Bone: endosteal perimeter2.14.39.2-0.9-1.7-1.9-2.1-1.4-2.8-1.42.9-0.1-2.1-3.0-2.5
Bone: final force0.30.42.20.60.71.50.31.10.20.20.20.50.50.40.4
Bone: final moment0.40.62.60.70.71.60.51.20.40.40.10.70.60.60.6
Bone: marrow area0.30.71.2-0.4-0.8-0.7-0.9-0.6-1.1-0.70.9-0.1-0.9-1.1-1.0
Bone: maximum diameter1.12.13.6-1.3-1.3-0.8-1.7-0.8-1.8-1.51.0-0.9-1.7-1.9-1.8
Bone: maximum force0.10.21.20.30.51.10.20.50.0-0.0-0.00.30.20.30.2
Bone: maximum moment0.10.21.40.40.41.20.30.60.20.1-0.20.30.40.50.4
Bone: minimum diameter0.30.61.3-0.5-0.7-0.2-0.9-0.2-1.1-0.70.9-0.2-0.9-1.2-1.0
Bone: periosteal estimation0.61.32.7-0.6-1.0-0.7-1.3-0.9-1.6-1.11.2-0.3-1.2-1.5-1.3
Bone: periosteal perimeter1.93.16.2-1.0-1.7-1.5-1.9-1.3-2.4-1.42.1-0.4-1.8-2.5-2.1
Bone: post-yield work1.21.62.41.31.31.41.41.11.31.0-0.60.91.41.61.5
Bone: stiffness0.50.72.40.71.01.50.80.90.70.6-0.40.60.91.00.9
Bone: tissue strength0.70.72.00.80.20.71.00.10.90.7-0.60.71.01.41.0
Bone: trabecular number0.30.51.30.40.60.80.61.10.71.10.71.00.60.30.2
Bone: trabecular spacing1.31.73.4-1.3-1.2-1.3-1.4-1.5-1.3-1.8-0.7-1.6-1.4-0.9-1.1
Bone: trabecular thickness0.20.31.50.10.40.2-0.30.3-0.50.01.20.5-0.2-0.7-0.5
Bone: trabecular tissue density2.33.24.52.11.82.11.91.51.61.70.01.72.01.82.0
Breakpoint value in progressive ratio session1.21.32.3-1.1-1.3-1.2-1.1-1.5-1.2-1.30.0-1.1-1.2-1.1-1.1
Distance traveled before self-admin1.61.82.81.21.31.71.41.51.41.3-0.41.21.41.51.3
Distance traveled after self-admin0.10.10.5-0.30.20.20.10.60.50.1-0.7-0.30.10.40.2
Delta time in closed arm before/after self-admin0.10.10.4-0.10.50.3-0.10.10.1-0.4-0.6-0.4-0.00.30.0
Delta time in open arm before/after self-admin0.20.21.00.0-1.0-0.6-0.1-0.5-0.20.20.30.1-0.1-0.4-0.1
Diff in mean of infusions in LGA sessions1.61.82.5-1.6-1.1-1.3-1.6-1.0-1.3-1.5-0.1-1.4-1.5-1.4-1.5
Extinction: sum of active levers before priming0.30.31.10.2-0.0-0.7-0.3-1.0-0.8-0.30.90.1-0.3-0.6-0.3
Active lever presses in extinction session 61.91.82.7-1.5-1.3-1.2-1.5-1.2-1.3-1.7-0.5-1.5-1.5-1.1-1.3
Delta distance traveled before/after self-admin2.22.34.5-2.1-1.4-1.6-1.6-1.0-1.0-1.7-0.9-2.1-1.7-1.2-1.5
Delta ambulatory time before/after self-admin1.21.32.5-1.5-1.2-1.1-1.2-0.7-0.7-1.3-0.6-1.6-1.2-0.9-1.1
Time in closed arm before self-admin0.91.06.70.6-0.2-0.4-0.10.5-0.70.72.61.3-0.1-1.2-0.7
Time in closed arm after self-admin0.90.93.4-0.1-0.4-0.8-0.8-0.4-1.3-0.41.80.3-0.8-1.5-1.1
Time in open arm before self-admin0.70.82.30.11.11.00.60.61.00.2-1.5-0.30.61.31.0
Time in open arm after self-admin0.10.10.5-0.1-0.5-0.40.1-0.60.2-0.0-0.7-0.40.10.20.4
Sum of active levers in priming session hrs 5-60.20.20.4-0.60.2-0.4-0.5-0.1-0.4-0.50.2-0.4-0.5-0.6-0.6
Time to tail flick, vehicle, before self-admin1.21.21.7-1.3-0.9-0.9-1.2-1.0-1.2-1.20.2-1.0-1.3-1.2-1.3
Time to tail flick, vehicle, after self-admin1.51.62.9-1.3-1.7-1.3-1.4-1.0-1.4-1.10.5-1.0-1.4-1.6-1.3
Time to tail flick, test, before self-admin0.50.51.2-1.1-0.8-0.3-0.8-0.2-0.5-0.6-0.1-1.0-0.8-0.8-0.8
Time to tail flick, test, after self-admin1.51.62.8-1.7-0.9-0.9-1.4-1.1-1.2-1.5-0.3-1.5-1.4-1.2-1.4
Delta time to tail flick, vehicle, before/after SA0.40.40.80.90.40.40.70.70.60.90.40.80.70.50.7
Delta time to tail flick, test, before/after SA0.10.10.2-0.20.20.0-0.2-0.3-0.2-0.4-0.3-0.1-0.20.1-0.2
Ambulatory time before self-admin0.91.01.70.61.01.20.91.01.20.7-1.10.41.01.31.0
Ambulatory time after self-admin0.20.20.9-0.5-0.1-0.0-0.10.30.5-0.2-0.9-0.7-0.10.40.1
Total heroin consumption0.30.30.5-0.5-0.2-0.4-0.6-0.7-0.7-0.70.1-0.5-0.6-0.7-0.7
Area under the delay curve0.80.82.71.30.90.40.90.10.00.71.61.50.80.20.4
Delay disc. indifference point, 0s delay1.81.93.9-0.5-1.4-1.4-1.3-1.0-1.8-0.91.90.0-1.3-2.0-1.6
Delay disc. indifference point, 16s delay0.30.31.90.40.4-0.00.1-0.1-0.40.21.40.80.1-0.4-0.2
Delay disc. indifference point, 2s delay1.61.811.61.70.3-0.20.5-0.2-0.80.83.42.20.5-0.8-0.1
Delay disc. indifference point, 24s delay0.20.20.4-0.60.50.4-0.40.2-0.3-0.7-0.2-0.4-0.4-0.2-0.6
Delay disc. indifference point, 4s delay0.50.62.41.20.2-0.10.6-0.4-0.30.51.61.30.60.10.4
Delay disc. indifference point, 8s delay1.11.12.31.51.40.61.30.40.71.00.81.41.20.91.0
Delay discount exponential model param0.80.82.0-1.3-1.1-0.6-1.0-0.2-0.2-0.7-1.3-1.4-0.9-0.4-0.5
Delay discount hyperbolic model param0.80.82.7-1.3-0.9-0.4-0.9-0.1-0.0-0.7-1.6-1.5-0.8-0.2-0.4
Fecal boli incidents, locomotor time 10.60.72.50.81.60.51.10.20.80.7-0.30.50.90.90.8
Change in fecal boli incidents, locomotor task0.80.82.5-0.5-1.6-1.2-0.8-1.3-0.8-0.70.1-0.6-0.7-0.7-0.5
Time >=10cm from walls, locomotor time 11.61.62.9-0.9-1.5-1.7-1.2-1.6-1.4-0.90.8-0.7-1.2-1.5-1.2
Bouts of movement, locomotor time 10.20.20.8-0.60.00.4-0.20.90.3-0.1-0.6-0.5-0.20.1-0.2
Total resting periods, locomotor time 10.20.31.6-0.20.30.70.21.30.60.3-0.6-0.10.20.40.2
Rest time, locomotor task time 10.40.41.10.00.40.50.50.81.00.3-1.1-0.20.41.00.7
Distance moved, locomotor task time 11.21.32.3-0.8-1.5-1.1-1.3-1.1-1.4-1.00.7-0.6-1.1-1.5-1.2
Vertical activity count, locomotor time 12.62.74.5-1.2-2.0-1.5-1.8-1.6-2.0-1.51.0-0.9-1.7-2.1-1.9
Time >=10cm from walls, locomotor time 23.43.65.0-1.7-2.0-2.2-2.1-2.0-2.1-1.90.4-1.4-2.0-2.1-2.1
Bouts of movement, locomotor time 20.50.51.60.71.30.50.90.50.70.7-0.00.60.90.70.7
Total resting periods, locomotor time 20.60.61.90.81.40.50.90.60.70.80.20.70.90.70.7
Rest time, locomotor task time 21.72.03.31.11.61.01.71.31.81.4-0.90.81.51.71.6
Distance moved, locomotor task time 22.93.45.0-1.7-2.1-1.3-2.2-1.2-2.2-2.00.7-1.3-2.1-2.2-2.2
Vertical activity count, locomotor time 23.74.15.9-1.9-2.1-1.6-2.3-1.9-2.4-2.20.7-1.5-2.2-2.4-2.4
Weight adjusted by age4.75.37.0-2.2-2.5-2.0-2.6-2.3-2.6-2.60.3-2.1-2.5-2.3-2.4
Seeking ratio, delayed vs. immediate footshock0.40.51.00.80.50.10.80.50.71.00.20.80.80.50.8
Locomotion in novel chamber0.50.63.6-0.70.00.5-0.10.40.7-0.3-1.9-1.0-0.00.80.2
Locomotion in novel chamber post-restriction0.20.20.8-0.0-0.50.2-0.50.4-0.5-0.00.90.3-0.4-0.6-0.5
Progressive ratio0.20.20.5-0.7-0.20.3-0.40.20.0-0.5-0.7-0.7-0.40.1-0.2
Food seeking constrained by brief footshock2.83.46.3-1.9-1.5-1.5-2.1-1.9-2.1-2.5-0.3-1.7-2.0-1.6-2.1
Seeking ratio, punishment vs. effort0.30.30.7-0.1-0.3-0.8-0.4-0.8-0.9-0.50.60.0-0.4-0.6-0.6
Run reversals in cocaine runway, females0.20.20.90.0-0.10.70.20.90.50.2-0.7-0.00.20.50.4
Run reversals in cocaine runway, males0.80.81.61.11.20.80.81.10.40.80.81.20.70.50.4
Latency to leave start box in cocaine runway0.90.92.3-1.3-0.20.0-1.1-0.6-0.8-1.5-0.9-1.3-1.0-0.4-1.0
Latency to leave start box in cocaine runway, F0.91.04.5-1.4-0.40.1-0.7-0.20.1-1.1-2.1-1.7-0.60.3-0.3
Latency to leave start box in cocaine runway, M0.40.41.10.00.70.0-0.5-0.3-1.1-0.70.90.3-0.5-0.7-0.8
Cd content in liver0.30.30.70.80.70.30.7-0.00.50.5-0.00.50.70.60.9
Co content in liver0.91.01.9-0.9-0.7-0.9-1.2-0.6-1.2-0.90.7-0.5-1.2-1.3-1.4
Cu content in liver5.36.411.21.82.93.32.52.92.92.0-1.81.22.53.02.6
Fe content in liver0.10.10.40.3-0.4-0.4-0.1-0.3-0.4-0.20.60.1-0.1-0.5-0.1
K content in liver0.20.21.3-0.20.50.60.11.10.40.50.30.20.0-0.1-0.2
Mg content in liver0.40.41.20.30.50.60.31.00.30.81.10.90.3-0.1-0.1
Mn content in liver0.10.10.3-0.4-0.50.0-0.10.50.10.40.60.2-0.2-0.4-0.5
Na content in liver2.93.16.12.21.71.31.71.81.02.32.22.51.70.51.4
Rb content in liver0.30.40.70.70.80.80.50.60.30.60.70.90.50.20.3
Se content in liver0.50.61.6-1.2-1.1-0.4-0.8-0.1-0.2-0.7-0.8-1.2-0.8-0.4-0.8
Sr content in liver2.52.33.21.21.71.61.61.51.81.4-0.80.91.61.81.7
Zn content in liver0.20.20.50.10.70.40.30.70.50.2-0.6-0.00.30.50.4