Hub : Genes

Ankrd52

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000030597 0.1 0.06 1.1e-09 0.07 0.07 0.05 0.06 1.1e-08 4.7e-08 7.0e-06 1.7e-07
2 Adipose mRNA stability ENSRNOG00000030597 0.06 0.05 1.4e-04 0.03 0.03 0.02 0.03 1.6e-04 6.3e-04 9.7e-04 7.7e-04
3 Eye mRNA stability ENSRNOG00000030597 0.24 0.16 9.9e-03 0.1 0.06 0.07 0.06 1.4e-02 4.7e-02 3.3e-02 3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.99.327.1-0.70.7-5.2
BMI without tail0.71.42.8-0.80.8-1.7
Body weight0.62.57.1-0.40.4-2.7
Epididymis fat weight0.10.10.2-0.30.30.4
Glucose0.61.02.8-0.10.2-1.7
Heart weight0.10.20.3-0.60.50.2
Left kidney weight0.71.92.51.6-1.6-0.8
Right kidney weight0.30.80.90.9-0.80.8
Tail length1.85.415.9-0.40.44.0
Length with tail0.51.95.10.5-0.52.3
Length without tail0.41.01.21.0-1.1-0.8
Liver weight, left0.71.11.6-0.90.9-1.3
Liver weight, right0.20.41.1-0.20.0-1.0
Parametrial fat weight0.10.20.3-0.50.40.4
Retroperitoneal fat weight0.93.07.4-0.90.9-2.7
Intraocular pressure0.91.21.6-1.21.30.8
Extensor digitorum longus weight2.510.121.0-2.12.2-4.6
Soleus weight2.67.521.3-0.70.8-4.6
Tibialis anterior weight0.62.05.6-0.40.4-2.4
Tibia length0.30.92.7-0.10.21.6
Number of licking bursts2.02.43.4-1.41.4-1.8
Food consumed during 24 hour testing period0.20.20.7-0.10.1-0.8
Times rat made contact with spout0.70.91.0-0.90.9-1.0
Mean time between licks in bursts0.60.92.1-0.50.61.4
Mean num. licks in bursts0.40.50.80.6-0.60.9
Std. dev. time between licks in bursts1.11.41.71.3-1.30.8
Water consumed over 24 hours1.01.21.31.1-1.1-1.1
Indifference point 0 sec1.21.95.70.3-0.2-2.4
Indifference point AUC0.10.10.4-0.10.10.6
Indifference point function ln k0.00.00.0-0.00.1-0.0
Indifference point function log k0.00.00.0-0.00.1-0.0
Delay discounting total patch changes 0 sec1.01.64.80.1-0.1-2.2
Delay discounting total patch changes 12 sec1.01.31.9-1.01.0-1.4
Delay discounting total patch changes 18 sec0.00.00.00.00.0-0.2
Delay discounting total patch changes 24 sec0.40.51.20.3-0.3-1.1
Delay discounting total patch changes 6 sec0.60.92.6-0.10.1-1.6
Delay discounting time to switch 0 sec0.40.71.10.7-0.7-1.1
Delay discounting water rate 0 sec0.50.81.3-1.11.1-0.3
Delay discounting water rate 12 sec0.71.01.4-1.21.2-0.4
Delay discounting water rate 18 sec2.73.64.9-2.22.20.9
Delay discounting water rate 24 sec3.85.37.9-2.82.8-0.3
Delay discounting water rate 6 sec1.52.22.7-1.41.41.6
Locomotor activity1.52.43.51.4-1.31.9
Locomotor testing distance0.61.11.70.9-0.91.3
Locomotor testing rearing0.10.20.2-0.50.50.1
Light reinforcement 11.83.38.60.9-0.82.9
Light reinforcement 20.50.71.90.3-0.31.4
Reaction time number correct0.91.31.6-1.21.3-0.9
Reaction time mean minus median0.40.61.40.4-0.41.2
Reaction time mean minus median AUC1.72.23.11.8-1.70.7
Reaction time num false alarms0.30.40.8-0.50.5-0.9
Reaction time num false alarms AUC0.50.70.8-0.90.8-0.8
Reaction time trials correct on left0.91.31.6-1.21.3-0.9
Reaction time trials on left0.81.11.3-1.11.2-0.9
Reaction time mean0.81.11.41.1-1.20.7
Reaction time mean AUC0.60.81.21.1-1.10.3
Median of all reaction times0.60.81.21.0-1.10.4
Reaction time omissions0.10.10.20.4-0.50.1
Reaction time false alarm rate0.10.10.30.1-0.1-0.5
Reaction time premature initiation rate1.21.63.0-1.01.01.7
Reaction time premature initiations1.72.42.8-1.71.71.3
Std. dev. reaction times0.50.70.80.9-0.90.7
Reaction time trials completed0.81.11.3-1.11.2-0.9
Reaction time trials AUC1.11.52.0-1.41.4-0.9
Social response proportion0.40.40.50.7-0.70.6
Social responses3.34.38.71.5-1.52.9
Social time0.50.71.4-0.60.6-1.2
Conditioned locomotion1.72.02.7-1.61.7-0.7
Cocaine response after cond. corrected2.22.53.0-1.71.7-1.2
Cocaine response after cond. not corrected2.42.73.6-1.91.8-1.1
Cocaine response before conditioning0.30.40.70.5-0.60.8
Saline control response0.30.40.7-0.50.5-0.8
Condit. Reinf. active minus inactive responses1.62.04.7-0.80.82.2
Condit. Reinf. active-inactive response ratio2.12.22.6-1.51.61.3
Condit. Reinf. active responses0.81.13.20.0-0.01.8
Condit. Reinf. inactive responses0.40.50.70.8-0.80.5
Condit. Reinf. lever presses1.41.94.9-0.60.62.2
Condit. Reinf. lever reinforcers received0.70.92.7-0.30.31.6
Pavlov. Cond. lever latency0.40.61.7-0.30.2-1.3
Pavlov. Cond. magazine entry latency0.80.92.40.4-0.51.5
Pavlov. Cond. change in total contacts0.30.41.20.00.01.1
Pavlov. Cond. index score0.70.92.70.2-0.21.6
Pavlov. Cond. latency score0.70.92.30.4-0.41.5
Pavlov. Cond. lever contacts0.50.72.0-0.10.21.4
Pavlov. Cond. magazine entry number0.81.02.6-0.40.5-1.6
Pavlov. Cond. intertrial magazine entries0.60.80.9-0.90.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.81.02.80.3-0.31.7
Pavlov. Cond. response bias0.81.23.4-0.20.21.8
Conditioned reinforcement - actives0.40.40.60.8-0.80.3
Conditioned reinforcement - inactives0.80.91.4-1.21.2-0.1
Conditioned locomotion1.92.36.10.6-0.62.5
Intermittent access intake day 1-15 change0.70.72.1-0.20.21.5
Intermittent access intake escalation1.81.82.2-1.21.21.5
Intermittent access intake escalation 21.71.73.2-1.01.01.8
Intermitt. access day 1 inactive lever presses1.41.51.6-1.31.31.2
Intermitt. access day 15 inactive lever presses1.31.43.1-0.80.81.7
Intermitt. access escalation Index1.41.21.81.3-1.30.1
Intermittent access day 1 total infusions0.20.30.70.2-0.2-0.8
Intermittent access day 15 total infusions0.10.10.2-0.40.40.2
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.4-0.0
Intermittent access total infusions0.10.10.2-0.10.1-0.4
Intermittent access day 1 locomotion0.00.00.0-0.20.2-0.1
Intermittent access day 15 total locomotion0.60.72.0-0.20.21.4
Intermittent access total locomotion0.10.10.40.2-0.20.6
Intermittent access standard deviation0.60.71.6-0.40.41.3
Cocaine induced anxiety1.31.52.01.4-1.40.8
Post-drug Anxiety2.22.53.71.9-1.9-0.2
Baseline Anxiety0.10.10.2-0.40.40.0
Lifetime Intake0.30.30.70.3-0.3-0.8
Incentive Sensitization - Responses0.10.10.40.1-0.10.6
Incentive Sensitization - Breakpoint0.20.20.40.4-0.40.7
Progressive ratio test 1 active lever presses0.40.51.2-0.30.3-1.1
Progressive ratio test 1 breakpoint0.50.51.4-0.20.2-1.2
Progressive ratio test 1 inactive lever presses0.20.20.60.3-0.30.8
Progressive ratio test 2 active lever presses0.10.10.20.1-0.1-0.5
Progressive ratio test 2 breakpoint0.30.30.40.6-0.6-0.2
Progressive ratio test 2 inactive lever presses0.20.20.30.5-0.5-0.2
Total sessions with >9 infusions1.41.52.21.5-1.5-0.3
Short access day 1 total inactive lever presses0.10.10.10.2-0.20.3
Short access day 10 total inactive lever presses0.70.80.8-0.90.90.9
Short access day 1 total infusions1.51.62.21.5-1.5-0.7
Short access day 10 total infusions0.20.20.50.1-0.1-0.7
Short access total infusions1.21.31.41.1-1.1-1.2
Short access day 1 locomotion0.30.40.50.7-0.70.2
Short access day 10 total locomotion1.81.95.3-0.50.52.3
Short access total locomotion0.20.20.40.4-0.40.7
Compulsive drug intake0.20.20.70.1-0.1-0.8
One hour access (0.3 mA shock)0.10.10.3-0.00.0-0.6
One hour access (shock baseline)0.30.40.5-0.70.70.4
Number of responses in last shaping day0.90.92.70.2-0.21.7
Context. condit. distance diff. score0.10.10.1-0.30.2-0.4
Locomotion velocity, session 11.61.72.31.5-1.4-0.9
Locomotion distance, session 11.72.33.41.8-1.8-0.1
Locomotion velocity, session 22.63.14.42.1-2.10.8
Locomotion distance, session 22.43.44.72.2-2.11.0
Locomotion velocity, session 31.72.05.90.3-0.22.4
Locomotion distance, session 30.00.00.1-0.10.20.2
Stereotopy head waving bouts, day 32.42.96.71.0-1.02.6
Stereotopy head waving duration, day 31.92.35.70.7-0.82.4
Locomotion velocity, session 70.20.30.40.6-0.60.3
Locomotion distance, session 70.40.50.8-0.80.90.0
Stereotopy head waving bouts, day 71.21.42.01.4-1.40.5
Stereotopy head waving duration, day 71.51.82.71.6-1.70.2
Locomotion velocity, session 82.32.84.12.0-2.00.3
Locomotion distance, session 80.20.30.50.7-0.70.3
Degree of sensitization distance0.20.20.5-0.10.0-0.7
Degree of sensitization stereotypy0.80.81.01.0-1.0-0.8
Condit. Reinf. active minus inactive responses1.01.12.90.4-0.41.7
Condit. Reinf. active-inactive response ratio0.40.40.9-0.50.41.0
Condit. Reinf. active responses1.82.23.21.3-1.31.8
Condit. Reinf. inactive responses1.51.82.41.5-1.50.9
Incentive salience index mean1.11.31.31.2-1.11.1
Condit. Reinf. lever presses2.12.94.32.1-2.1-0.3
Time in familiar zone, hab. session 12.01.95.3-0.40.32.3
Time in novel zone, hab. session 12.52.54.71.2-1.2-2.2
Total zone transitions, hab. session 11.31.93.11.8-1.60.1
Total locomotion distance, hab. session 13.24.66.82.6-2.50.8
Locomotion velocity, hab. session 12.33.34.62.1-2.11.0
Time in familiar zone, hab. session 22.72.87.2-0.70.82.7
Time in novel zone, hab. session 23.13.27.51.0-1.0-2.7
Total zone transitions, hab. session 22.22.93.81.9-1.8-1.2
Total locomotion distance, hab. session 21.11.52.31.5-1.40.1
Locomotion velocity, hab. session 21.72.33.51.9-1.8-0.0
Novel to familiar place preference ratio2.52.64.41.3-1.3-2.1
Novelty place preference1.92.02.81.2-1.3-1.7
Time in novel zone, NPP test1.92.03.51.1-1.2-1.9
Total zone transitions, NPP test0.81.11.41.0-0.9-1.2
Total locomotion distance, NPP test1.11.52.11.4-1.4-0.7
Locomotion velocity, NPP test0.91.32.01.4-1.3-0.4
Pavlov. Cond. lever latency1.01.21.8-1.31.30.2
Pavlov. Cond. magazine entry latency0.60.82.5-0.00.11.6
Pavlov. Cond. change in total contacts0.10.10.10.3-0.2-0.4
Pavlov. Cond. index score0.50.70.91.0-0.90.5
Pavlov. Cond. latency score0.91.21.71.3-1.30.4
Pavlov. Cond. lever contacts1.61.92.71.6-1.6-0.5
Pavlov. Cond. magazine entry number0.20.20.6-0.20.1-0.8
Pavlov. Cond. intertrial magazine entries0.60.71.0-1.00.90.6
Pavlov. Cond. lever-magazine prob. diff.0.50.70.90.9-0.90.6
Pavlov. Cond. response bias0.20.30.70.3-0.30.9
Bone: apparent density3.05.07.12.6-2.7-0.9
Bone surface5.810.315.33.9-3.9-0.5
Bone volume6.110.415.33.9-3.9-0.9
Bone: connectivity density1.82.84.02.0-2.0-0.6
Bone: cortical apparent density0.50.61.7-0.30.3-1.3
Bone: cortical area1.42.22.41.5-1.6-1.3
Bone: cortical porosity0.40.40.60.8-0.80.2
Bone: cortical porosity0.90.91.31.1-1.1-0.4
Bone: cortical thickness0.71.12.40.6-0.7-1.5
Bone: cortical thickness0.40.50.7-0.70.7-0.8
Bone: cortical tissue density0.40.51.2-0.30.3-1.1
Bone: elastic displacement0.10.10.10.3-0.30.2
Bone: elastic work0.50.71.20.7-0.7-1.1
Bone: endosteal estimation0.40.81.10.8-0.8-1.1
Bone: endosteal perimeter0.71.52.21.5-1.50.5
Bone: final force1.93.16.51.1-1.2-2.5
Bone: final moment1.82.96.11.2-1.2-2.5
Bone: marrow area0.30.71.00.8-0.8-1.0
Bone: maximum diameter1.32.33.41.8-1.80.5
Bone: maximum force1.62.96.71.0-1.0-2.6
Bone: maximum moment1.62.86.31.0-1.0-2.5
Bone: minimum diameter0.71.21.61.2-1.2-0.7
Bone: periosteal estimation1.32.62.71.6-1.7-1.5
Bone: periosteal perimeter1.32.13.11.8-1.8-0.3
Bone: post-yield work0.10.10.4-0.00.0-0.6
Bone: stiffness1.93.08.50.5-0.6-2.9
Bone: tissue strength1.51.54.40.2-0.2-2.1
Bone: trabecular number1.62.53.81.9-1.90.2
Bone: trabecular spacing3.74.87.1-2.72.70.5
Bone: trabecular thickness7.28.712.33.5-3.5-1.2
Bone: trabecular tissue density2.63.66.8-1.41.4-2.6
Breakpoint value in progressive ratio session1.31.44.1-0.20.22.0
Distance traveled before self-admin0.40.40.80.4-0.50.9
Distance traveled after self-admin0.20.20.30.5-0.40.4
Delta time in closed arm before/after self-admin3.63.55.5-2.32.30.1
Delta time in open arm before/after self-admin1.11.13.10.2-0.2-1.8
Diff in mean of infusions in LGA sessions1.01.23.5-0.1-0.01.9
Extinction: sum of active levers before priming2.02.03.8-1.11.11.9
Active lever presses in extinction session 60.40.40.70.5-0.50.8
Delta distance traveled before/after self-admin0.00.00.10.3-0.1-0.2
Delta ambulatory time before/after self-admin0.30.30.60.7-0.6-0.3
Time in closed arm before self-admin1.31.41.71.3-1.3-1.0
Time in closed arm after self-admin0.00.00.00.1-0.0-0.2
Time in open arm before self-admin0.90.92.0-0.60.51.4
Time in open arm after self-admin0.70.71.2-0.70.7-1.1
Sum of active levers in priming session hrs 5-60.10.10.4-0.10.10.6
Time to tail flick, vehicle, before self-admin3.33.44.32.1-2.01.3
Time to tail flick, vehicle, after self-admin0.70.81.0-1.01.00.6
Time to tail flick, test, before self-admin1.51.42.01.4-1.40.5
Time to tail flick, test, after self-admin0.91.01.51.2-1.2-0.0
Delta time to tail flick, vehicle, before/after SA3.23.14.1-2.02.0-1.1
Delta time to tail flick, test, before/after SA0.40.40.5-0.70.70.4
Ambulatory time before self-admin0.10.10.40.2-0.20.6
Ambulatory time after self-admin0.10.10.20.4-0.30.2
Total heroin consumption0.91.02.10.7-0.71.5
Area under the delay curve0.20.30.40.4-0.4-0.6
Delay disc. indifference point, 0s delay3.03.34.41.6-1.6-2.1
Delay disc. indifference point, 16s delay0.10.10.20.2-0.20.4
Delay disc. indifference point, 2s delay0.70.81.10.8-0.8-1.0
Delay disc. indifference point, 24s delay0.30.30.80.1-0.1-0.9
Delay disc. indifference point, 4s delay0.80.91.31.1-1.1-0.0
Delay disc. indifference point, 8s delay0.40.40.5-0.70.7-0.5
Delay discount exponential model param0.20.20.3-0.40.40.5
Delay discount hyperbolic model param0.30.30.6-0.50.40.7
Fecal boli incidents, locomotor time 11.11.21.5-1.21.2-0.7
Change in fecal boli incidents, locomotor task1.61.52.31.5-1.50.3
Time >=10cm from walls, locomotor time 11.11.11.11.0-1.0-1.1
Bouts of movement, locomotor time 10.20.20.7-0.20.20.8
Total resting periods, locomotor time 10.40.41.30.1-0.11.1
Rest time, locomotor task time 10.20.20.30.5-0.50.4
Distance moved, locomotor task time 10.91.01.11.0-1.0-0.9
Vertical activity count, locomotor time 10.30.30.5-0.40.4-0.7
Time >=10cm from walls, locomotor time 20.50.60.7-0.70.7-0.8
Bouts of movement, locomotor time 20.80.91.41.1-1.20.2
Total resting periods, locomotor time 21.11.21.81.3-1.30.1
Rest time, locomotor task time 20.50.60.91.0-1.0-0.2
Distance moved, locomotor task time 20.50.60.9-1.01.00.2
Vertical activity count, locomotor time 21.51.72.2-1.51.5-0.8
Weight adjusted by age0.30.40.6-0.70.70.3
Seeking ratio, delayed vs. immediate footshock1.11.31.81.0-1.01.3
Locomotion in novel chamber0.00.00.0-0.10.1-0.2
Locomotion in novel chamber post-restriction1.31.64.50.4-0.32.1
Progressive ratio0.40.50.7-0.60.6-0.9
Food seeking constrained by brief footshock0.40.41.30.1-0.11.1
Seeking ratio, punishment vs. effort0.60.71.90.3-0.31.4
Run reversals in cocaine runway, females0.70.71.10.8-0.71.0
Run reversals in cocaine runway, males1.31.32.40.8-0.91.6
Latency to leave start box in cocaine runway1.82.02.51.6-1.6-1.0
Latency to leave start box in cocaine runway, F3.33.74.82.1-2.2-1.3
Latency to leave start box in cocaine runway, M0.60.51.0-0.81.00.2
Cd content in liver0.20.20.50.00.1-0.7
Co content in liver0.70.92.0-0.40.71.4
Cu content in liver1.51.82.71.6-1.3-1.0
Fe content in liver0.40.50.6-0.80.8-0.6
K content in liver0.90.91.51.2-1.00.5
Mg content in liver1.21.21.91.4-1.3-0.1
Mn content in liver4.14.87.32.6-2.7-0.0
Na content in liver0.30.30.40.6-0.6-0.5
Rb content in liver1.01.31.81.2-1.3-0.7
Se content in liver0.10.10.20.5-0.2-0.0
Sr content in liver1.71.51.8-1.31.31.0
Zn content in liver3.03.33.4-1.81.91.8