Hub : Genes

Apeh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000029572	0.2	0.1	7.0e-07	0	0.04	0.04	0.01	1.3e-01	1.2e-05	9.6e-06	9.4e-03
2	Adipose	mRNA stability	ENSRNOG00000029572	0.14	0.09	1.0e-03	0	0.02	0.01	-0	2.5e-01	3.2e-03	2.4e-02	4.3e-01
3	Liver	gene expression	ENSRNOG00000029572	0.16	0.09	1.3e-04	-0	0.03	0.03	0	6.0e-01	4.1e-04	2.4e-04	1.4e-01
4	Liver	mRNA stability	ENSRNOG00000029572	0.03	0.02	1.6e-03	0.01	0.02	0	0.01	3.4e-02	4.2e-03	1.4e-01	1.4e-02
5	PL	mRNA stability	ENSRNOG00000029572	0.18	0.15	5.0e-03	0.03	0.03	0.04	0.02	1.9e-03	5.1e-03	4.2e-04	1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	2.5	8.1	23.5	-2.3	-3.4	-4.8	0.2	-0.4
BMI without tail	1.9	4.1	13.5	-1.6	-1.9	-3.7	-0.6	0.6
Body weight	1.2	5.0	19.9	-0.4	-2.2	-4.5	-0.1	0.5
Epididymis fat weight	0.3	0.7	1.4	-0.6	-0.9	-1.2	0.1	-0.9
Glucose	0.6	0.9	2.2	-0.3	0.3	-0.3	-1.4	1.5
Heart weight	0.7	1.1	2.3	1.1	0.5	1.5	0.5	-1.1
Left kidney weight	1.6	4.7	11.1	-2.3	-1.3	-3.3	-2.0	1.2
Right kidney weight	1.0	2.7	3.9	-1.9	-0.7	-2.0	-2.0	1.3
Tail length	0.6	1.8	3.4	1.2	1.4	-0.2	-1.4	1.9
Length with tail	0.4	1.5	2.9	1.7	1.0	-0.6	-1.1	1.5
Length without tail	0.2	0.5	2.1	1.5	0.4	-0.2	-0.2	0.4
Liver weight, left	1.8	2.8	6.4	1.6	1.7	1.0	-1.2	2.5
Liver weight, right	0.9	1.5	3.4	-0.2	0.8	-0.4	-1.8	1.8
Parametrial fat weight	0.7	1.4	4.8	0.1	-0.1	-1.3	-0.7	2.2
Retroperitoneal fat weight	0.2	0.5	1.2	-0.3	0.2	-0.8	-1.1	0.7
Intraocular pressure	4.5	6.3	13.2	2.6	3.1	3.6	-1.1	1.0
Extensor digitorum longus weight	0.2	0.8	1.7	-0.4	-0.8	-0.2	1.2	-1.3
Soleus weight	0.4	1.2	4.6	0.0	-0.8	-2.1	-0.3	0.6
Tibialis anterior weight	0.3	1.0	1.4	-0.7	-1.1	-1.2	0.7	-1.0
Tibia length	3.1	8.7	30.9	-2.0	-2.6	-5.6	-0.8	1.0
Number of licking bursts	1.1	1.4	3.8	1.2	-0.6	0.4	1.9	-1.0
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.2	0.2	-0.1	-0.3	0.1
Times rat made contact with spout	0.3	0.3	1.1	1.0	0.1	0.1	0.4	0.5
Mean time between licks in bursts	0.3	0.4	0.6	0.6	-0.4	0.8	0.5	-0.8
Mean num. licks in bursts	1.2	1.4	3.4	-0.8	0.8	-0.4	-1.9	1.5
Std. dev. time between licks in bursts	2.6	3.1	8.2	-0.2	-1.2	0.9	2.2	-2.9
Water consumed over 24 hours	0.9	1.0	2.3	0.6	-1.3	-0.7	1.5	-0.5
Indifference point 0 sec	1.9	3.1	6.1	0.4	2.1	0.9	-1.9	2.5
Indifference point AUC	0.8	0.9	2.1	-0.2	-0.5	-1.3	-0.9	1.4
Indifference point function ln k	1.6	2.2	4.3	-2.1	-1.1	-1.6	-0.1	-1.7
Indifference point function log k	1.6	2.2	4.3	-2.1	-1.1	-1.6	-0.1	-1.7
Delay discounting total patch changes 0 sec	1.6	2.5	4.6	0.6	2.2	1.2	-1.6	1.9
Delay discounting total patch changes 12 sec	0.7	0.9	2.2	0.7	1.0	0.4	-0.7	1.5
Delay discounting total patch changes 18 sec	3.0	3.9	7.8	1.9	2.1	1.3	-1.4	2.8
Delay discounting total patch changes 24 sec	0.4	0.5	1.1	0.8	0.6	0.3	-0.6	1.1
Delay discounting total patch changes 6 sec	1.5	2.2	7.4	0.4	1.1	0.2	-1.5	2.7
Delay discounting time to switch 0 sec	0.4	0.5	2.3	0.5	-0.4	-0.0	1.5	-0.2
Delay discounting water rate 0 sec	0.5	0.7	1.7	1.3	0.7	1.2	-0.3	0.1
Delay discounting water rate 12 sec	0.1	0.1	0.3	-0.2	-0.2	-0.6	-0.2	-0.1
Delay discounting water rate 18 sec	1.5	2.0	2.9	-1.3	-1.7	-1.3	0.8	-1.7
Delay discounting water rate 24 sec	0.2	0.3	0.7	0.6	0.4	0.8	-0.2	-0.6
Delay discounting water rate 6 sec	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.6	-0.1
Locomotor activity	1.0	1.6	3.7	0.3	1.9	1.1	-1.7	0.2
Locomotor testing distance	0.8	1.4	3.3	0.2	1.7	0.9	-1.8	0.2
Locomotor testing rearing	0.4	0.6	1.6	0.3	1.1	1.3	-0.1	0.2
Light reinforcement 1	0.4	0.8	2.7	-0.6	-0.6	-1.6	-0.1	0.7
Light reinforcement 2	3.0	3.9	9.7	-1.8	-1.8	-3.1	-0.5	1.8
Reaction time number correct	0.2	0.3	0.5	-0.7	-0.1	0.5	0.7	-0.5
Reaction time mean minus median	0.2	0.3	0.7	-0.3	-0.8	-0.9	-0.4	-0.1
Reaction time mean minus median AUC	0.2	0.3	0.5	0.1	-0.4	-0.7	-0.5	0.6
Reaction time num false alarms	2.9	4.0	12.9	0.8	2.0	3.6	-0.8	-1.4
Reaction time num false alarms AUC	3.1	4.3	12.8	0.8	2.4	3.6	-1.2	-1.0
Reaction time trials correct on left	0.2	0.3	0.5	-0.7	-0.1	0.5	0.7	-0.5
Reaction time trials on left	0.2	0.3	0.5	-0.7	-0.1	0.6	0.7	-0.5
Reaction time mean	0.3	0.5	1.3	1.1	0.5	0.7	-0.5	-0.2
Reaction time mean AUC	0.4	0.6	1.6	1.3	0.6	0.7	-0.6	0.1
Median of all reaction times	0.7	0.9	2.1	1.4	0.9	1.2	-0.4	-0.2
Reaction time omissions	1.9	2.6	6.4	2.0	1.6	2.5	0.2	-0.2
Reaction time false alarm rate	2.8	4.0	11.1	1.2	2.2	3.3	-1.2	-1.1
Reaction time premature initiation rate	1.3	1.7	4.3	-0.1	-0.5	-2.1	-0.2	2.0
Reaction time premature initiations	0.9	1.3	3.3	-0.6	-0.7	-1.8	0.2	1.4
Std. dev. reaction times	0.2	0.3	0.8	0.7	0.3	0.2	-0.9	0.5
Reaction time trials completed	0.2	0.3	0.5	-0.7	-0.1	0.6	0.7	-0.5
Reaction time trials AUC	0.2	0.3	0.6	-0.8	-0.1	0.6	0.7	-0.5
Social response proportion	0.2	0.2	0.5	0.1	0.3	-0.5	0.3	0.7
Social responses	0.1	0.2	0.4	-0.6	0.2	-0.2	-0.6	0.3
Social time	1.8	2.4	4.5	-1.0	-1.6	-0.8	1.8	-2.1
Conditioned locomotion	0.3	0.4	1.2	-1.1	0.1	-0.2	-0.0	0.9
Cocaine response after cond. corrected	1.1	1.3	2.8	-0.3	-0.8	-0.5	1.6	-1.7
Cocaine response after cond. not corrected	0.6	0.7	2.1	-0.5	-0.5	-0.5	0.8	-1.5
Cocaine response before conditioning	0.5	0.6	2.6	-0.5	0.2	-0.2	-1.6	0.4
Saline control response	2.9	3.9	6.0	0.8	2.4	1.4	-2.2	2.4
Condit. Reinf. active minus inactive responses	0.8	1.0	3.4	-0.5	-0.9	-1.9	0.1	0.6
Condit. Reinf. active-inactive response ratio	1.0	1.0	2.9	-0.4	-1.4	-1.7	0.5	-0.2
Condit. Reinf. active responses	0.6	0.8	2.8	-0.4	-0.4	-1.7	0.0	1.0
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.1	0.5	-0.1	-0.1	0.7
Condit. Reinf. lever presses	0.8	1.1	3.5	-0.7	-1.0	-1.9	-0.1	0.7
Condit. Reinf. lever reinforcers received	0.6	0.9	3.0	-0.3	-0.4	-1.7	0.1	1.1
Pavlov. Cond. lever latency	0.4	0.5	1.2	0.6	0.9	1.1	0.0	-0.2
Pavlov. Cond. magazine entry latency	1.6	1.9	3.9	-1.1	-2.0	-1.9	0.6	-0.4
Pavlov. Cond. change in total contacts	0.9	1.2	4.0	0.0	-1.2	-2.0	0.3	0.7
Pavlov. Cond. index score	1.1	1.5	3.3	-0.7	-1.8	-1.7	0.5	-0.3
Pavlov. Cond. latency score	1.1	1.4	3.2	-0.7	-1.8	-1.7	0.5	-0.3
Pavlov. Cond. lever contacts	0.4	0.6	1.4	-0.4	-0.7	-1.2	-0.5	0.8
Pavlov. Cond. magazine entry number	1.5	1.8	3.9	0.8	2.0	1.9	-0.9	0.0
Pavlov. Cond. intertrial magazine entries	2.9	3.7	10.7	1.5	2.2	3.3	-0.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	4.0	-0.9	-2.0	-1.9	0.6	-0.4
Pavlov. Cond. response bias	1.1	1.5	3.5	-1.0	-1.7	-1.9	0.3	-0.0
Conditioned reinforcement - actives	0.4	0.4	1.2	-0.0	0.4	1.1	-0.3	0.7
Conditioned reinforcement - inactives	8.0	9.1	36.4	1.9	-0.9	0.3	2.1	-6.0
Conditioned locomotion	1.4	1.6	6.3	-1.0	0.3	-0.3	-0.9	2.5
Intermittent access intake day 1-15 change	6.3	6.2	26.6	1.3	-0.4	0.4	1.6	-5.2
Intermittent access intake escalation	5.0	5.0	20.9	1.2	-0.5	0.1	1.5	-4.6
Intermittent access intake escalation 2	6.8	6.8	29.5	1.1	-0.5	0.2	1.7	-5.4
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.7	0.8	-0.1	0.6	0.2	-0.4
Intermitt. access day 15 inactive lever presses	6.7	7.4	30.2	1.5	-0.9	0.2	1.9	-5.5
Intermitt. access escalation Index	1.1	0.9	2.4	-0.9	-0.1	-1.1	-0.4	1.5
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.2	-0.5	0.0	0.3
Intermittent access day 15 total infusions	1.3	1.4	5.2	0.8	-0.5	-0.5	0.9	-2.3
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.4	0.5	-0.6	-0.9	0.6	-1.2
Intermittent access total infusions	0.2	0.2	0.6	0.4	-0.4	-0.4	0.4	-0.8
Intermittent access day 1 locomotion	0.2	0.2	0.7	-0.2	-0.4	-0.8	-0.0	0.6
Intermittent access day 15 total locomotion	1.1	1.2	3.6	-0.6	-0.2	-1.3	-0.4	1.9
Intermittent access total locomotion	1.1	1.3	4.0	-0.6	-0.2	-1.3	-0.4	2.0
Intermittent access standard deviation	8.2	8.7	36.6	1.3	-1.0	-0.5	2.0	-6.0
Cocaine induced anxiety	1.5	1.7	7.4	0.4	0.0	0.8	0.6	-2.7
Post-drug Anxiety	0.5	0.5	2.3	0.3	-0.1	0.1	0.5	-1.5
Baseline Anxiety	0.5	0.5	1.5	-0.3	0.5	0.7	-0.5	1.2
Lifetime Intake	0.1	0.1	0.2	0.2	-0.2	-0.4	0.1	0.2
Incentive Sensitization - Responses	2.0	2.0	8.7	0.6	-0.3	0.2	0.9	-2.9
Incentive Sensitization - Breakpoint	2.0	2.0	8.8	0.5	-0.3	0.4	0.9	-3.0
Progressive ratio test 1 active lever presses	2.3	2.3	10.3	-0.5	0.1	-0.7	-0.9	3.2
Progressive ratio test 1 breakpoint	2.3	2.4	10.5	-0.4	0.2	-0.6	-0.9	3.2
Progressive ratio test 1 inactive lever presses	2.2	2.4	9.1	1.1	-0.6	-0.0	1.1	-3.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.1	-0.1	-0.1	0.3	-0.6
Progressive ratio test 2 inactive lever presses	9.7	11.2	47.9	1.5	-0.7	0.8	2.1	-6.9
Total sessions with >9 infusions	3.2	3.5	13.8	0.9	-0.8	-0.6	1.4	-3.7
Short access day 1 total inactive lever presses	1.9	2.1	8.6	0.8	-0.4	0.0	1.0	-2.9
Short access day 10 total inactive lever presses	10.8	11.9	44.4	2.2	-1.6	-0.9	2.6	-6.7
Short access day 1 total infusions	0.9	1.0	3.6	0.5	-0.6	-0.5	0.8	-1.9
Short access day 10 total infusions	0.3	0.4	1.6	0.3	-0.1	-0.4	-0.2	1.3
Short access total infusions	0.3	0.3	1.1	0.1	-0.2	-0.7	-0.1	1.1
Short access day 1 locomotion	1.4	1.5	3.9	0.2	-1.1	-2.0	0.8	-1.4
Short access day 10 total locomotion	1.5	1.7	7.0	-0.5	-0.0	-0.8	-0.7	2.6
Short access total locomotion	2.5	2.5	10.9	-0.3	-0.0	-0.9	-0.8	3.3
Compulsive drug intake	1.9	1.9	7.6	-0.7	-0.0	-0.8	-0.7	2.8
One hour access (0.3 mA shock)	0.7	0.8	2.2	-0.1	-0.4	-1.2	-0.2	1.5
One hour access (shock baseline)	0.2	0.2	0.6	0.4	-0.3	-0.4	0.4	-0.8
Number of responses in last shaping day	2.8	2.8	12.2	0.6	-0.6	0.0	1.2	-3.5
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.2	0.0
Locomotion velocity, session 1	0.4	0.4	1.4	-1.2	-0.5	-0.5	-0.4	0.1
Locomotion distance, session 1	1.7	2.2	4.2	-2.0	-1.0	-2.0	-1.3	0.5
Locomotion velocity, session 2	1.1	1.3	3.0	-1.7	-1.1	-0.8	0.1	-1.3
Locomotion distance, session 2	1.6	2.3	6.4	-2.5	-0.9	-1.6	-1.3	-0.3
Locomotion velocity, session 3	2.1	2.4	5.0	-1.9	-1.1	-2.2	-1.4	0.6
Locomotion distance, session 3	1.9	2.1	4.3	-2.1	-1.4	-1.8	-0.8	-0.2
Stereotopy head waving bouts, day 3	0.8	1.0	2.7	1.1	-0.3	0.4	1.6	-1.0
Stereotopy head waving duration, day 3	0.6	0.8	1.8	1.3	0.6	0.8	0.9	0.3
Locomotion velocity, session 7	1.0	1.1	2.9	-0.3	0.7	-0.1	-1.4	1.7
Locomotion distance, session 7	0.3	0.4	1.1	-1.0	-0.2	-0.3	-0.7	0.4
Stereotopy head waving bouts, day 7	0.1	0.2	0.4	-0.3	0.4	-0.0	-0.5	0.6
Stereotopy head waving duration, day 7	0.3	0.3	0.7	-0.4	0.1	-0.7	-0.5	0.9
Locomotion velocity, session 8	3.1	3.7	9.2	-2.3	-1.6	-3.0	-1.0	0.5
Locomotion distance, session 8	2.8	4.2	9.0	-3.0	-1.0	-2.5	-2.1	0.8
Degree of sensitization distance	1.1	1.1	2.0	1.4	1.1	0.9	0.1	1.2
Degree of sensitization stereotypy	0.6	0.6	1.4	-0.3	0.7	0.0	-1.1	1.2
Condit. Reinf. active minus inactive responses	0.7	0.8	2.2	1.5	-0.0	0.6	1.2	0.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.2	1.4	0.0	0.8	1.5	-0.2
Condit. Reinf. active responses	0.3	0.4	1.0	0.9	-0.4	-0.1	1.0	0.2
Condit. Reinf. inactive responses	0.3	0.4	0.9	-1.0	-0.5	-0.7	-0.3	-0.2
Incentive salience index mean	0.4	0.4	1.0	0.4	-0.9	-0.6	1.0	0.1
Condit. Reinf. lever presses	0.8	1.1	2.5	-0.9	-1.6	-1.3	0.8	-0.3
Time in familiar zone, hab. session 1	1.5	1.4	2.6	1.4	0.6	1.6	1.4	-0.2
Time in novel zone, hab. session 1	0.4	0.4	1.0	-0.6	-0.4	-1.0	-0.5	0.2
Total zone transitions, hab. session 1	1.7	2.4	4.4	-2.1	-0.9	-2.1	-1.5	0.1
Total locomotion distance, hab. session 1	0.6	0.8	1.9	-1.0	-0.5	-1.4	-0.9	-0.0
Locomotion velocity, hab. session 1	0.7	1.0	2.1	-1.1	-0.4	-1.5	-1.1	0.2
Time in familiar zone, hab. session 2	0.9	0.9	2.4	0.4	-0.7	0.4	1.5	-1.1
Time in novel zone, hab. session 2	0.8	0.8	1.4	0.3	1.2	0.9	-1.0	0.7
Total zone transitions, hab. session 2	2.1	2.7	5.6	-2.4	-1.5	-2.0	-0.7	-1.1
Total locomotion distance, hab. session 2	0.8	1.0	2.6	-1.1	-0.8	-1.6	-0.9	-0.1
Locomotion velocity, hab. session 2	0.9	1.2	2.9	-1.3	-0.8	-1.7	-1.0	-0.1
Novel to familiar place preference ratio	4.1	4.4	9.8	-0.9	2.1	0.4	-3.1	2.6
Novelty place preference	4.8	5.0	11.0	-0.8	2.4	0.7	-3.3	2.7
Time in novel zone, NPP test	4.5	4.7	9.4	-0.4	2.5	0.8	-3.1	2.7
Total zone transitions, NPP test	4.1	5.8	11.8	-3.0	-1.5	-3.4	-2.4	0.2
Total locomotion distance, NPP test	0.8	1.0	2.1	-1.1	-0.6	-1.5	-1.2	-0.2
Locomotion velocity, NPP test	1.0	1.5	2.8	-1.3	-0.6	-1.7	-1.5	-0.1
Pavlov. Cond. lever latency	3.2	4.0	6.4	2.1	2.5	1.8	-1.3	2.1
Pavlov. Cond. magazine entry latency	2.8	3.7	6.9	-1.4	-2.2	-0.9	2.0	-2.6
Pavlov. Cond. change in total contacts	1.0	1.1	3.1	0.6	-1.2	-0.6	1.8	-0.3
Pavlov. Cond. index score	2.7	3.4	5.7	-1.1	-2.2	-1.0	2.1	-2.4
Pavlov. Cond. latency score	2.7	3.5	5.3	-1.5	-2.3	-1.2	1.8	-2.3
Pavlov. Cond. lever contacts	2.3	2.8	5.1	-1.4	-2.3	-1.9	1.2	-1.4
Pavlov. Cond. magazine entry number	2.1	2.6	5.3	0.8	1.7	0.4	-2.0	2.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	0.7	0.9	1.0	-0.7	0.4
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.9	6.1	-0.9	-2.4	-1.1	2.4	-2.5
Pavlov. Cond. response bias	3.3	4.0	6.5	-1.2	-2.4	-1.1	2.2	-2.6
Bone: apparent density	0.6	0.9	2.7	-0.3	0.4	-0.2	-1.2	1.7
Bone surface	0.8	1.4	3.3	-1.4	-1.3	-1.8	-0.1	0.3
Bone volume	0.4	0.7	1.4	-1.0	-0.8	-1.2	-0.4	0.5
Bone: connectivity density	1.2	1.9	5.0	-0.0	1.4	0.7	-1.5	2.2
Bone: cortical apparent density	0.2	0.3	0.6	0.1	0.7	0.7	-0.3	0.7
Bone: cortical area	1.6	2.4	5.0	0.4	-1.6	-0.0	2.1	-2.2
Bone: cortical porosity	2.6	2.8	4.1	0.9	2.0	1.8	-1.5	1.9
Bone: cortical porosity	3.1	3.3	5.2	0.9	2.2	2.3	-1.6	1.8
Bone: cortical thickness	1.6	2.7	5.8	0.7	-1.9	-0.6	2.4	-1.9
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.3	0.1	0.4	-0.2
Bone: cortical tissue density	0.3	0.4	0.6	0.1	0.7	0.8	-0.4	0.7
Bone: elastic displacement	0.3	0.4	1.0	0.8	-0.3	0.4	1.0	-0.3
Bone: elastic work	1.3	1.7	3.6	-0.6	-1.8	-1.9	1.1	-0.5
Bone: endosteal estimation	0.2	0.4	0.9	0.1	0.6	0.0	-0.7	0.9
Bone: endosteal perimeter	0.3	0.7	1.9	-1.0	-0.5	0.3	0.1	-1.4
Bone: final force	0.9	1.4	2.8	0.1	-1.6	-1.7	1.3	-0.1
Bone: final moment	1.0	1.7	3.2	0.1	-1.7	-1.8	1.5	-0.5
Bone: marrow area	0.2	0.4	0.9	0.0	0.6	-0.1	-0.8	0.9
Bone: maximum diameter	1.1	2.0	4.7	0.1	-1.5	-0.1	1.7	-2.2
Bone: maximum force	0.4	0.8	1.7	0.4	-1.0	-1.3	0.8	0.5
Bone: maximum moment	0.5	0.8	1.8	0.3	-1.1	-1.3	0.9	0.1
Bone: minimum diameter	0.4	0.7	2.3	-0.4	-0.8	0.3	0.5	-1.5
Bone: periosteal estimation	0.2	0.4	0.7	-0.1	-0.9	-0.6	0.7	-0.6
Bone: periosteal perimeter	0.6	1.0	2.9	-0.5	-0.9	0.4	1.0	-1.7
Bone: post-yield work	0.6	0.8	3.0	-0.7	-0.8	-1.7	-0.0	0.4
Bone: stiffness	0.1	0.2	0.6	0.4	-0.3	-0.5	0.3	0.7
Bone: tissue strength	0.8	0.7	1.2	1.0	-0.7	-1.1	1.0	-0.1
Bone: trabecular number	0.7	1.1	2.2	-1.2	0.2	-0.3	-1.4	1.5
Bone: trabecular spacing	0.7	0.9	1.8	1.2	-0.4	-0.1	1.3	-1.2
Bone: trabecular thickness	0.6	0.8	1.8	-0.7	-0.2	-0.9	-1.3	0.9
Bone: trabecular tissue density	0.2	0.3	1.2	0.3	0.3	-0.4	-0.5	1.1
Breakpoint value in progressive ratio session	0.2	0.3	0.9	0.4	0.1	-0.4	-0.5	0.9
Distance traveled before self-admin	0.9	1.0	3.0	-0.2	-0.3	1.1	0.9	-1.7
Distance traveled after self-admin	0.5	0.5	1.2	-0.0	-0.7	0.2	0.9	-1.1
Delta time in closed arm before/after self-admin	0.7	0.6	2.1	-0.3	-0.8	-1.5	0.3	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.2	0.1	-0.1	-0.3	0.6
Diff in mean of infusions in LGA sessions	1.0	1.1	2.3	1.1	-0.3	0.4	1.5	-1.3
Extinction: sum of active levers before priming	0.7	0.7	1.5	0.1	0.9	0.8	-1.2	0.8
Active lever presses in extinction session 6	0.8	0.8	2.4	-0.0	-0.1	-1.0	-0.8	1.5
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.2	-0.1	-0.6	-0.2	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	1.0	0.4	0.1	-0.7	-0.5	1.0
Time in closed arm before self-admin	0.3	0.4	1.1	1.1	0.3	-0.2	-0.0	0.7
Time in closed arm after self-admin	0.3	0.3	0.8	0.1	-0.6	-0.9	0.6	-0.0
Time in open arm before self-admin	0.2	0.2	0.5	-0.7	-0.3	0.3	0.2	-0.7
Time in open arm after self-admin	0.7	0.8	1.6	-0.7	0.1	-0.6	-1.2	1.3
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.0	0.7	0.3	-0.9	0.6
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	0.9	0.8	0.4	-0.6	0.9
Time to tail flick, vehicle, after self-admin	1.5	1.6	5.0	0.3	1.2	2.2	-0.0	-1.3
Time to tail flick, test, before self-admin	1.3	1.3	4.0	0.1	0.2	-1.0	-1.2	2.0
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.1	0.1	0.5	0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	3.7	-0.3	0.3	1.7	0.6	-1.9
Delta time to tail flick, test, before/after SA	0.4	0.4	1.0	-0.2	-0.3	0.2	0.8	-1.0
Ambulatory time before self-admin	2.4	2.5	10.8	0.8	-0.3	0.3	1.1	-3.3
Ambulatory time after self-admin	0.1	0.1	0.3	-0.2	-0.6	-0.4	0.2	-0.1
Total heroin consumption	1.0	1.2	5.0	0.1	1.0	2.2	-0.3	-0.4
Area under the delay curve	0.3	0.3	1.0	-1.0	-0.2	-0.4	-0.5	0.2
Delay disc. indifference point, 0s delay	1.0	1.1	2.9	0.2	-1.1	-1.7	0.5	0.9
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.6	-0.4	-0.8	-0.2	0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.4	-0.4	-0.5	0.0	0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	-0.7	-0.1	-0.3	-0.3	0.1
Delay disc. indifference point, 4s delay	0.9	1.0	2.6	-0.9	-1.0	-1.6	0.6	-0.2
Delay disc. indifference point, 8s delay	0.6	0.6	1.2	-1.1	0.5	0.8	-0.9	-0.2
Delay discount exponential model param	0.2	0.3	1.0	1.0	0.1	0.2	0.4	0.1
Delay discount hyperbolic model param	0.3	0.3	1.1	1.0	0.2	0.4	0.4	-0.0
Fecal boli incidents, locomotor time 1	0.5	0.5	1.5	0.7	0.7	1.2	-0.2	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.2	0.1	-0.4	-0.4	0.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	-0.5	0.7	0.9	-1.1	0.4
Bouts of movement, locomotor time 1	0.2	0.2	0.8	0.1	-0.3	-0.9	0.3	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.1	-0.2	-0.7	0.2	0.1
Rest time, locomotor task time 1	0.4	0.4	1.6	-0.1	-0.5	-1.3	0.2	0.2
Distance moved, locomotor task time 1	0.6	0.7	2.1	0.4	0.8	1.4	-0.2	-0.6
Vertical activity count, locomotor time 1	1.2	1.2	3.5	0.2	1.3	1.9	-0.8	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	0.3	0.5	0.4	-0.6	0.7
Bouts of movement, locomotor time 2	0.6	0.7	1.2	-0.2	-0.9	-0.7	1.1	-0.9
Total resting periods, locomotor time 2	0.6	0.7	1.0	-0.4	-0.9	-0.7	1.0	-1.0
Rest time, locomotor task time 2	0.5	0.6	2.2	-0.1	-0.6	-1.5	0.2	0.6
Distance moved, locomotor task time 2	0.9	1.1	3.3	0.0	1.0	1.8	-0.4	-1.0
Vertical activity count, locomotor time 2	1.3	1.4	4.5	-0.5	1.1	2.1	-0.8	-0.8
Weight adjusted by age	0.9	1.1	3.0	0.5	0.6	1.7	0.4	-1.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	1.0	-1.0	-0.1	-0.2	-0.5	0.0
Locomotion in novel chamber	0.6	0.7	1.6	0.3	-1.0	-0.6	1.3	-0.5
Locomotion in novel chamber post-restriction	0.4	0.5	1.1	0.1	0.6	0.1	-1.0	1.1
Progressive ratio	0.7	0.9	2.1	-0.2	1.1	0.6	-1.4	0.8
Food seeking constrained by brief footshock	0.4	0.5	0.8	-0.7	-0.9	-0.4	0.8	-0.8
Seeking ratio, punishment vs. effort	1.0	1.2	2.7	-0.2	-0.9	0.4	1.5	-1.7
Run reversals in cocaine runway, females	1.3	1.3	3.6	-0.1	0.3	1.9	0.4	-1.6
Run reversals in cocaine runway, males	0.9	0.9	2.3	1.1	0.7	1.5	0.2	-0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.6	-0.1	-0.3	0.2	0.7
Latency to leave start box in cocaine runway, F	0.5	0.5	1.2	1.1	0.3	0.8	0.7	-0.4
Latency to leave start box in cocaine runway, M	1.1	1.1	2.6	-0.5	-0.6	-1.6	-0.4	1.4
Cd content in liver	2.6	2.8	7.9	2.8	1.4	1.7	0.9	0.7
Co content in liver	0.5	0.5	1.2	0.2	-0.7	-0.3	1.1	-0.9
Cu content in liver	2.1	2.5	5.8	1.7	1.6	0.4	-1.1	2.4
Fe content in liver	3.6	4.3	10.9	3.3	1.9	2.2	0.7	1.1
K content in liver	1.7	1.7	4.5	-1.3	-0.9	-2.1	-0.9	0.9
Mg content in liver	2.3	2.4	5.5	-1.9	-1.5	-2.4	-0.6	-0.0
Mn content in liver	1.0	1.2	2.6	-1.2	0.2	-0.8	-1.6	1.1
Na content in liver	2.1	2.3	3.5	1.7	1.9	1.6	-0.7	1.4
Rb content in liver	4.9	6.1	14.7	3.8	2.2	3.0	1.2	1.0
Se content in liver	0.7	0.8	2.0	-1.0	-1.0	-1.4	-0.2	-0.4
Sr content in liver	2.5	2.3	4.7	-2.0	-1.5	-2.2	-0.5	-0.5
Zn content in liver	1.0	1.0	3.0	0.4	0.4	-0.9	-1.0	1.7