Hub : Genes

Echdc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000029333	0.07	0.04	2.8e-04	0.04	0.04	0.04	0.04	1.9e-05	2.6e-05	6.7e-05	2.5e-05
2	Adipose	mRNA stability	ENSRNOG00000029333	0.04	0.03	1.9e-04	0.02	0.02	0.02	0.02	3.1e-03	3.6e-03	1.4e-03	3.3e-03
3	Brain	mRNA stability	ENSRNOG00000029333	0.03	0.02	2.4e-03	0.01	0.02	0.01	0.01	1.3e-02	6.2e-03	4.0e-02	3.3e-02
4	Liver	alternative polyA	ENSRNOT00000047653	0.23	0.16	4.3e-03	0.03	0.01	0.03	0.03	5.5e-04	2.2e-02	3.9e-04	1.7e-04
5	Liver	alternative polyA	ENSRNOT00000096852	0.22	0.17	9.4e-03	0.02	0.01	0.03	0.03	8.9e-04	3.4e-02	3.8e-04	1.9e-04
6	Liver	gene expression	ENSRNOG00000029333	0.25	0.11	0.0e+00	0.16	0.18	0.18	0.18	6.0e-17	1.0e-19	1.1e-19	1.4e-19
7	Liver	mRNA stability	ENSRNOG00000029333	0.15	0.08	0.0e+00	0.09	0.1	0.1	0.1	7.0e-10	1.0e-11	1.7e-11	2.3e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.5	1.7	3.6	0.2	1.6	1.7	-0.8	0.6	1.4	1.9
BMI without tail	0.1	0.2	0.5	0.3	-0.2	-0.4	0.6	-0.7	-0.3	-0.4
Body weight	0.4	1.6	5.5	1.0	2.3	1.2	-0.2	-0.0	0.9	1.5
Epididymis fat weight	0.2	0.5	1.1	-1.1	-0.4	-0.0	1.0	-1.0	0.2	-0.3
Glucose	0.1	0.1	0.6	-0.8	0.1	0.2	0.2	-0.1	0.3	0.0
Heart weight	0.6	0.9	2.5	1.0	1.6	0.7	-0.6	0.6	0.5	1.1
Left kidney weight	4.0	11.5	29.0	1.3	5.4	4.0	-0.4	0.3	3.4	4.7
Right kidney weight	3.0	8.5	23.5	2.0	4.8	3.1	-0.5	0.3	2.5	3.9
Tail length	0.6	1.7	3.2	1.5	-0.5	-1.8	0.6	-0.6	-1.7	-1.6
Length with tail	0.2	0.8	2.8	1.7	1.0	-0.8	-0.1	-0.1	-0.9	-0.4
Length without tail	0.4	1.0	3.1	0.5	1.8	0.9	-0.7	0.5	0.6	1.2
Liver weight, left	0.2	0.4	1.3	1.1	1.0	0.2	-0.2	0.1	0.0	0.5
Liver weight, right	0.6	1.0	2.4	1.6	0.2	-0.5	-1.4	1.3	-0.8	-0.1
Parametrial fat weight	0.8	1.6	4.8	2.2	0.4	-1.4	-0.9	0.5	-1.6	-0.9
Retroperitoneal fat weight	0.1	0.2	0.4	0.5	-0.1	-0.7	-0.1	-0.2	-0.7	-0.6
Intraocular pressure	0.2	0.4	0.5	-0.6	0.6	0.7	0.4	-0.4	0.7	0.6
Extensor digitorum longus weight	0.6	2.5	4.1	1.2	2.0	1.5	-1.7	1.4	1.0	2.0
Soleus weight	1.3	3.6	7.5	0.1	2.7	2.4	-0.4	0.2	2.1	2.7
Tibialis anterior weight	2.0	7.0	14.7	2.2	3.8	2.6	-2.0	1.8	1.8	3.5
Tibia length	0.1	0.4	0.7	-0.2	0.4	0.8	0.5	-0.4	0.9	0.7
Number of licking bursts	0.5	0.6	1.6	1.3	0.6	-0.1	-1.0	0.9	-0.3	0.3
Food consumed during 24 hour testing period	1.8	2.1	3.9	-2.0	0.6	1.2	1.8	-1.7	1.5	0.7
Times rat made contact with spout	1.2	1.4	2.6	-1.1	0.7	1.0	1.6	-1.6	1.1	0.7
Mean time between licks in bursts	0.7	0.9	2.5	-1.1	-1.6	-0.8	0.5	-0.4	-0.5	-1.2
Mean num. licks in bursts	1.3	1.5	2.5	-1.6	0.3	1.1	1.6	-1.5	1.3	0.7
Std. dev. time between licks in bursts	1.7	2.1	5.4	-0.4	-2.3	-1.6	-0.6	0.8	-1.4	-1.9
Water consumed over 24 hours	1.2	1.4	2.0	-1.2	0.9	1.2	1.4	-1.2	1.4	0.9
Indifference point 0 sec	0.6	1.0	1.7	-0.4	1.2	0.8	1.2	-1.3	0.9	0.8
Indifference point AUC	0.6	0.7	1.9	0.1	0.6	-0.5	1.3	-1.4	-0.4	-0.5
Indifference point function ln k	0.3	0.4	0.6	-0.2	-0.0	0.8	-0.6	0.6	0.7	0.8
Indifference point function log k	0.3	0.4	0.6	-0.2	-0.0	0.8	-0.6	0.6	0.7	0.8
Delay discounting total patch changes 0 sec	0.5	0.7	1.5	-0.2	1.1	0.6	1.1	-1.2	0.7	0.6
Delay discounting total patch changes 12 sec	0.7	1.0	1.8	0.0	-0.8	-1.2	1.0	-1.1	-1.0	-1.3
Delay discounting total patch changes 18 sec	0.1	0.1	0.3	-0.1	0.5	0.5	-0.2	0.1	0.4	0.5
Delay discounting total patch changes 24 sec	0.6	0.7	1.9	-0.1	1.4	0.9	0.4	-0.4	0.9	1.0
Delay discounting total patch changes 6 sec	0.9	1.4	3.4	-1.0	0.9	0.6	1.8	-1.8	0.8	0.3
Delay discounting time to switch 0 sec	1.9	2.9	5.4	0.6	-2.3	-1.5	-1.9	2.0	-1.6	-1.5
Delay discounting water rate 0 sec	1.4	2.3	5.8	-0.0	2.4	1.7	0.9	-1.0	1.6	1.8
Delay discounting water rate 12 sec	2.5	3.8	8.4	-0.6	2.9	2.2	1.2	-1.2	2.2	2.3
Delay discounting water rate 18 sec	0.1	0.2	0.5	0.7	0.7	-0.3	0.1	-0.3	-0.3	-0.1
Delay discounting water rate 24 sec	0.1	0.2	0.7	0.8	0.6	-0.1	-0.3	0.4	-0.2	0.2
Delay discounting water rate 6 sec	1.1	1.6	3.6	-0.1	1.9	1.3	0.9	-1.0	1.3	1.4
Locomotor activity	0.8	1.3	2.8	-1.6	0.0	0.7	1.7	-1.6	1.0	0.2
Locomotor testing distance	1.9	3.1	6.2	-2.1	0.7	1.3	2.5	-2.4	1.7	0.8
Locomotor testing rearing	1.2	1.9	5.5	-2.3	-0.1	1.1	1.6	-1.4	1.4	0.6
Light reinforcement 1	0.2	0.4	0.8	0.8	0.4	0.2	-0.9	0.9	0.0	0.4
Light reinforcement 2	0.7	0.9	2.8	0.5	1.7	1.0	0.3	-0.2	0.9	1.2
Reaction time number correct	0.3	0.4	1.4	1.2	0.6	-0.5	-0.6	0.5	-0.7	-0.2
Reaction time mean minus median	1.3	1.7	6.4	-2.5	-1.6	0.6	1.0	-0.9	0.9	-0.1
Reaction time mean minus median AUC	0.8	1.0	4.0	-2.0	-1.4	0.3	0.7	-0.6	0.6	-0.2
Reaction time num false alarms	1.3	1.8	2.9	-1.5	1.0	1.6	1.2	-1.0	1.7	1.3
Reaction time num false alarms AUC	1.8	2.6	4.5	-1.8	1.2	2.0	1.1	-0.9	2.1	1.6
Reaction time trials correct on left	0.3	0.4	1.4	1.2	0.6	-0.5	-0.6	0.5	-0.7	-0.2
Reaction time trials on left	0.2	0.3	1.0	1.0	0.5	-0.4	-0.6	0.4	-0.6	-0.1
Reaction time mean	0.9	1.2	4.0	-2.0	-1.2	0.1	1.2	-1.1	0.5	-0.4
Reaction time mean AUC	0.7	0.9	2.6	-1.6	-1.4	-0.2	0.8	-0.8	0.1	-0.7
Median of all reaction times	0.6	0.8	2.0	-1.4	-1.2	-0.2	0.8	-0.8	0.0	-0.6
Reaction time omissions	1.5	2.1	8.4	-2.9	-1.6	0.8	0.9	-0.8	1.1	0.1
Reaction time false alarm rate	2.2	3.1	5.6	-2.1	1.0	2.2	1.4	-1.1	2.4	1.7
Reaction time premature initiation rate	0.9	1.3	3.8	-1.1	-0.4	0.0	1.9	-1.8	0.3	-0.3
Reaction time premature initiations	0.4	0.6	1.9	-0.4	-0.2	-0.4	1.4	-1.4	-0.2	-0.5
Std. dev. reaction times	1.6	2.1	7.6	-2.8	-1.3	0.8	1.4	-1.3	1.1	0.0
Reaction time trials completed	0.2	0.3	1.0	1.0	0.5	-0.4	-0.6	0.4	-0.6	-0.1
Reaction time trials AUC	0.2	0.3	0.8	0.9	0.8	-0.2	-0.5	0.3	-0.4	0.1
Social response proportion	0.3	0.3	0.9	-0.7	-1.0	-0.3	0.3	-0.3	-0.2	-0.6
Social responses	1.0	1.2	3.7	-0.7	-1.9	-1.1	-0.1	0.0	-1.0	-1.5
Social time	0.2	0.3	0.9	-1.0	-0.6	0.4	-0.2	0.2	0.5	0.2
Conditioned locomotion	0.5	0.6	2.1	1.5	0.2	-0.3	-0.8	0.9	-0.5	0.1
Cocaine response after cond. corrected	1.9	2.1	3.7	-1.2	1.2	1.9	0.9	-0.8	1.9	1.7
Cocaine response after cond. not corrected	2.0	2.2	4.0	-0.8	1.6	2.0	0.6	-0.4	2.0	1.9
Cocaine response before conditioning	0.2	0.2	0.4	0.6	0.7	0.0	-0.5	0.6	-0.1	0.2
Saline control response	0.6	0.9	2.3	-1.5	-0.1	0.8	1.0	-1.0	1.0	0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.6	-1.3	0.3	0.9	0.8	-0.8	1.0	0.6
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.3	-0.9	0.4	0.4	1.1	-1.1	0.6	0.2
Condit. Reinf. active responses	0.2	0.3	0.5	-0.6	0.4	0.7	0.1	-0.2	0.7	0.6
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.3	0.4	0.5	-0.7	0.6	0.4	0.7
Condit. Reinf. lever presses	0.5	0.6	2.0	-1.4	-0.7	0.2	0.9	-0.9	0.5	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.8	0.3	0.7	0.2	-0.3	0.8	0.5
Pavlov. Cond. lever latency	1.2	1.7	4.1	2.0	0.4	-0.6	-1.7	1.7	-1.0	0.0
Pavlov. Cond. magazine entry latency	2.1	2.5	5.3	-2.3	-1.3	-0.2	2.2	-2.1	0.3	-0.9
Pavlov. Cond. change in total contacts	1.5	2.1	5.6	-2.4	-0.7	0.6	1.9	-1.9	1.1	-0.1
Pavlov. Cond. index score	2.3	3.0	7.5	-2.7	-1.0	0.3	2.4	-2.4	0.9	-0.5
Pavlov. Cond. latency score	2.2	2.8	6.9	-2.6	-0.9	0.4	2.3	-2.3	0.9	-0.4
Pavlov. Cond. lever contacts	0.9	1.3	3.6	-1.9	-0.4	0.6	1.4	-1.4	1.0	0.1
Pavlov. Cond. magazine entry number	1.9	2.4	5.5	2.3	1.8	0.6	-1.7	1.7	0.1	1.4
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.8	1.7	0.1	-0.6	-1.5	1.4	-0.9	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.5	8.3	-2.9	-1.0	0.4	2.6	-2.6	0.9	-0.5
Pavlov. Cond. response bias	1.3	1.8	5.2	-2.3	-1.1	0.2	1.7	-1.6	0.6	-0.5
Conditioned reinforcement - actives	2.5	2.5	4.7	-1.6	1.2	2.2	0.6	-0.4	2.2	1.9
Conditioned reinforcement - inactives	0.2	0.2	0.4	0.0	0.1	0.5	-0.6	0.6	0.4	0.6
Conditioned locomotion	1.1	1.4	1.9	-0.8	1.1	1.2	1.4	-1.4	1.2	1.1
Intermittent access intake day 1-15 change	1.9	1.9	2.8	-0.9	1.7	1.6	1.0	-1.0	1.6	1.5
Intermittent access intake escalation	2.1	2.0	2.9	-1.4	1.4	1.6	1.2	-1.2	1.7	1.4
Intermittent access intake escalation 2	0.9	0.9	1.7	-1.1	0.7	0.7	1.3	-1.3	0.8	0.5
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.6	0.2	1.6	1.2	0.5	-0.5	1.1	1.4
Intermitt. access day 15 inactive lever presses	0.5	0.6	2.0	1.4	1.1	0.3	-0.5	0.3	0.1	0.7
Intermitt. access escalation Index	1.2	1.0	4.7	2.2	1.4	-0.1	-0.5	0.2	-0.4	0.4
Intermittent access day 1 total infusions	0.4	0.4	1.3	0.6	-0.1	0.3	-1.1	1.1	0.1	0.4
Intermittent access day 15 total infusions	0.9	1.0	1.9	-0.2	1.2	1.3	-0.2	0.2	1.2	1.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	-0.2	0.7	0.7	-0.1	0.1	0.7	0.7
Intermittent access total infusions	0.4	0.5	0.9	0.1	0.6	0.9	-0.6	0.7	0.7	1.0
Intermittent access day 1 locomotion	0.8	0.8	2.1	0.5	-0.0	0.7	-1.3	1.5	0.5	0.9
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.6	0.3	0.8	0.1	-0.0	0.8	0.7
Intermittent access total locomotion	0.4	0.5	1.0	0.3	0.6	0.9	-0.5	0.6	0.7	1.0
Intermittent access standard deviation	3.1	3.4	6.8	-1.3	1.4	2.6	-0.5	0.8	2.5	2.5
Cocaine induced anxiety	0.5	0.5	2.3	1.5	1.1	-0.0	-0.1	-0.2	-0.2	0.3
Post-drug Anxiety	1.7	1.9	5.1	2.3	-0.6	-1.1	-1.6	1.4	-1.3	-0.6
Baseline Anxiety	1.6	1.7	5.6	-0.3	-1.5	0.2	-2.0	2.4	0.1	0.1
Lifetime Intake	0.4	0.5	0.9	0.1	0.6	0.9	-0.6	0.6	0.7	1.0
Incentive Sensitization - Responses	0.3	0.3	0.8	-0.9	0.3	0.6	0.4	-0.4	0.7	0.4
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	-0.8	0.5	0.7	0.4	-0.3	0.8	0.6
Progressive ratio test 1 active lever presses	0.4	0.4	0.9	-0.0	-0.0	0.6	-0.9	0.9	0.5	0.6
Progressive ratio test 1 breakpoint	0.4	0.4	0.7	-0.1	0.3	0.8	-0.6	0.7	0.7	0.8
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.0	0.2	1.0	0.9	0.1	-0.0	0.8	1.0
Progressive ratio test 2 active lever presses	1.1	1.2	2.4	-1.2	0.7	1.6	0.0	0.1	1.5	1.4
Progressive ratio test 2 breakpoint	0.9	1.0	1.9	-0.6	0.9	1.4	-0.1	0.1	1.3	1.3
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.9	-0.2	1.2	1.3	0.2	-0.3	1.2	1.4
Total sessions with >9 infusions	0.1	0.1	0.4	-0.3	-0.6	-0.2	-0.0	0.1	-0.2	-0.3
Short access day 1 total inactive lever presses	2.4	2.7	5.6	0.7	2.4	2.0	-0.1	-0.1	1.8	2.4
Short access day 10 total inactive lever presses	2.2	2.5	7.5	0.4	2.7	1.2	1.4	-1.6	1.2	1.5
Short access day 1 total infusions	0.9	1.0	3.0	1.7	0.3	0.0	-1.4	1.2	-0.3	0.4
Short access day 10 total infusions	0.5	0.5	1.2	0.7	1.1	0.7	-0.5	0.4	0.5	0.9
Short access total infusions	0.4	0.5	0.9	0.5	0.7	0.8	-0.7	0.6	0.6	0.9
Short access day 1 locomotion	1.1	1.1	2.4	0.3	1.4	1.4	0.1	-0.3	1.2	1.6
Short access day 10 total locomotion	0.9	1.0	2.1	-0.2	1.4	1.2	0.6	-0.6	1.2	1.3
Short access total locomotion	0.2	0.2	0.5	0.4	0.7	0.4	0.3	-0.5	0.3	0.5
Compulsive drug intake	0.2	0.2	0.4	0.5	-0.2	-0.6	0.0	-0.1	-0.6	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.1	0.1	-0.1	0.4	-0.5	-0.1	-0.1
One hour access (shock baseline)	0.3	0.3	0.6	-0.3	0.6	0.8	0.1	-0.0	0.7	0.8
Number of responses in last shaping day	1.1	1.1	2.3	0.7	1.5	1.2	-0.5	0.2	1.0	1.5
Context. condit. distance diff. score	0.6	0.8	1.2	0.9	-0.5	-0.9	-1.1	1.0	-1.0	-0.7
Locomotion velocity, session 1	2.2	2.4	4.7	1.4	-1.2	-2.2	-0.3	0.3	-2.2	-1.9
Locomotion distance, session 1	0.2	0.3	0.8	0.9	0.6	-0.5	0.2	-0.2	-0.6	-0.2
Locomotion velocity, session 2	2.4	2.9	5.7	1.7	-1.1	-2.4	-0.6	0.6	-2.4	-2.0
Locomotion distance, session 2	0.7	1.0	1.3	-0.8	1.1	1.1	1.0	-1.0	1.1	0.9
Locomotion velocity, session 3	0.5	0.5	1.0	0.4	-0.6	-1.0	-0.5	0.4	-1.0	-0.9
Locomotion distance, session 3	0.2	0.2	0.6	-0.8	0.1	0.6	0.2	-0.1	0.6	0.4
Stereotopy head waving bouts, day 3	0.5	0.6	1.5	0.9	0.1	-0.4	-1.2	1.0	-0.6	-0.1
Stereotopy head waving duration, day 3	0.8	1.0	2.9	1.7	0.4	-1.0	-0.9	0.7	-1.2	-0.5
Locomotion velocity, session 7	0.1	0.1	0.8	-0.9	-0.3	0.1	0.0	0.0	0.1	-0.2
Locomotion distance, session 7	0.7	0.9	3.6	-1.9	-0.6	0.6	0.9	-0.8	0.9	0.1
Stereotopy head waving bouts, day 7	1.4	1.6	2.8	1.1	-0.8	-1.5	-1.1	1.0	-1.7	-1.3
Stereotopy head waving duration, day 7	1.5	1.8	3.1	1.1	-1.1	-1.7	-1.0	1.0	-1.8	-1.5
Locomotion velocity, session 8	1.2	1.4	2.5	0.6	-1.4	-1.6	-0.5	0.5	-1.6	-1.6
Locomotion distance, session 8	0.0	0.0	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.2	-0.1
Degree of sensitization distance	0.1	0.1	0.2	-0.5	-0.1	0.3	0.3	-0.3	0.4	0.2
Degree of sensitization stereotypy	0.6	0.7	1.2	0.5	-0.8	-1.0	-0.6	0.6	-1.1	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.1	0.3	0.7	-0.4	0.5	0.6	0.7
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.3	-0.1	0.3	0.8	-1.0	1.1	0.7	0.9
Condit. Reinf. active responses	0.5	0.6	1.3	0.1	0.9	1.0	0.1	0.0	0.9	1.2
Condit. Reinf. inactive responses	0.4	0.5	1.5	-0.3	0.4	0.3	1.1	-1.2	0.4	0.2
Incentive salience index mean	0.8	1.0	2.2	0.3	1.0	1.3	-0.5	0.6	1.1	1.5
Condit. Reinf. lever presses	0.7	0.9	2.0	0.6	1.4	1.1	-0.0	0.1	0.9	1.3
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.2	0.1	-0.7	0.6	-0.6	-0.6	-0.6
Time in novel zone, hab. session 1	0.3	0.3	1.2	-0.5	-1.1	0.0	-0.5	0.5	0.1	-0.2
Total zone transitions, hab. session 1	0.5	0.6	1.7	1.3	0.2	-0.7	-0.8	0.9	-0.9	-0.4
Total locomotion distance, hab. session 1	0.5	0.7	2.2	1.5	1.4	-0.0	-0.4	0.4	-0.3	0.4
Locomotion velocity, hab. session 1	0.4	0.6	2.2	1.4	1.5	-0.1	0.1	-0.1	-0.3	0.3
Time in familiar zone, hab. session 2	1.2	1.2	2.7	-1.6	-0.5	-0.1	1.7	-1.6	0.3	-0.6
Time in novel zone, hab. session 2	0.4	0.4	1.0	0.9	0.1	-0.0	-1.0	0.9	-0.2	0.3
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.6	0.3	0.3	0.8	-0.7	0.4	0.2
Total locomotion distance, hab. session 2	0.6	0.8	1.8	-0.1	1.3	0.7	1.1	-1.0	0.7	0.8
Locomotion velocity, hab. session 2	0.5	0.7	2.0	0.1	1.4	0.7	0.9	-0.8	0.7	0.8
Novel to familiar place preference ratio	1.9	2.0	3.1	-1.6	0.8	1.6	1.2	-1.2	1.8	1.3
Novelty place preference	1.2	1.2	1.8	-1.3	0.6	1.2	1.0	-1.0	1.3	0.9
Time in novel zone, NPP test	0.9	0.9	1.7	-1.3	0.3	1.1	0.8	-0.8	1.2	0.8
Total zone transitions, NPP test	0.4	0.5	1.1	0.8	1.1	0.6	-0.6	0.4	0.4	0.9
Total locomotion distance, NPP test	0.6	0.8	2.6	0.7	1.6	0.9	0.1	-0.1	0.7	1.2
Locomotion velocity, NPP test	0.9	1.3	3.8	0.7	2.0	1.2	0.2	-0.1	1.0	1.5
Pavlov. Cond. lever latency	0.9	1.1	2.4	-0.8	-1.5	-1.2	-0.0	0.1	-1.0	-1.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.2	-0.8	-0.4	0.2	-0.3	-0.3	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.6	-0.2	-0.2	-0.3	0.3	-0.2	-0.0
Pavlov. Cond. index score	0.1	0.2	0.4	0.5	0.4	0.5	-0.1	0.1	0.4	0.6
Pavlov. Cond. latency score	0.2	0.2	0.5	0.5	0.5	0.5	-0.2	0.2	0.4	0.7
Pavlov. Cond. lever contacts	0.8	0.9	1.7	1.2	1.2	0.9	-0.6	0.5	0.6	1.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	-0.3	1.0	0.5	0.6	-0.6	0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.8	2.1	3.2	-1.4	1.2	1.3	1.8	-1.8	1.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.3	0.4	0.6	0.1	-0.1	0.5	0.7
Pavlov. Cond. response bias	0.1	0.1	0.5	0.7	-0.1	0.0	-0.4	0.4	-0.0	0.2
Bone: apparent density	0.5	0.8	1.4	0.4	-1.2	-1.1	-0.3	0.3	-1.1	-1.2
Bone surface	0.2	0.3	0.7	-0.1	-0.8	-0.7	0.2	-0.2	-0.6	-0.8
Bone volume	0.1	0.2	0.4	0.1	-0.6	-0.5	-0.2	0.2	-0.4	-0.5
Bone: connectivity density	0.7	1.0	2.1	-0.1	-1.3	-1.3	0.5	-0.4	-1.1	-1.5
Bone: cortical apparent density	1.3	1.7	3.0	1.0	-1.3	-1.7	-0.4	0.3	-1.7	-1.6
Bone: cortical area	0.6	0.9	1.6	-0.5	1.0	1.3	0.4	-0.4	1.2	1.2
Bone: cortical porosity	2.1	2.3	4.5	2.1	-0.4	-0.9	-2.1	2.1	-1.3	-0.4
Bone: cortical porosity	2.2	2.4	4.3	1.9	-0.6	-1.2	-2.1	2.1	-1.5	-0.8
Bone: cortical thickness	1.3	2.1	4.5	-0.0	1.9	1.9	-0.1	0.1	1.7	2.1
Bone: cortical thickness	0.8	1.0	1.7	0.8	0.6	1.0	-1.3	1.1	0.7	1.3
Bone: cortical tissue density	1.4	1.8	3.4	1.1	-1.3	-1.9	-0.4	0.3	-1.8	-1.7
Bone: elastic displacement	0.3	0.4	1.2	1.1	1.1	-0.1	0.1	0.0	-0.3	0.2
Bone: elastic work	0.7	0.9	2.1	0.2	1.3	0.3	1.5	-1.3	0.4	0.4
Bone: endosteal estimation	0.1	0.2	0.4	-0.3	-0.5	-0.5	0.1	-0.0	-0.4	-0.6
Bone: endosteal perimeter	0.2	0.5	1.2	-1.1	-1.1	-0.4	0.5	-0.4	-0.2	-0.8
Bone: final force	0.0	0.0	0.2	-0.4	-0.2	0.0	0.1	-0.0	0.1	-0.1
Bone: final moment	0.1	0.1	0.3	-0.5	0.1	0.2	0.4	-0.3	0.3	0.1
Bone: marrow area	0.1	0.1	0.3	-0.2	-0.4	-0.4	0.2	-0.1	-0.3	-0.5
Bone: maximum diameter	0.0	0.1	0.2	0.3	-0.2	0.0	-0.5	0.4	-0.1	0.1
Bone: maximum force	0.1	0.1	0.4	-0.4	0.2	0.1	0.7	-0.6	0.1	-0.0
Bone: maximum moment	0.2	0.3	0.7	-0.5	0.4	0.2	0.8	-0.8	0.3	0.1
Bone: minimum diameter	0.8	1.4	3.1	-1.8	0.2	1.2	1.2	-1.2	1.4	0.8
Bone: periosteal estimation	0.1	0.1	0.3	-0.1	0.6	0.4	0.1	-0.1	0.4	0.4
Bone: periosteal perimeter	0.0	0.1	0.3	-0.6	-0.3	0.1	0.2	-0.2	0.2	-0.0
Bone: post-yield work	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.3	-0.2	-0.2	-0.4
Bone: stiffness	0.1	0.1	0.5	-0.2	-0.7	-0.1	-0.5	0.5	-0.1	-0.1
Bone: tissue strength	0.9	0.9	2.5	-0.9	-0.2	-0.4	1.6	-1.5	-0.1	-0.7
Bone: trabecular number	0.5	0.8	1.6	0.0	-1.1	-1.2	0.3	-0.3	-1.0	-1.3
Bone: trabecular spacing	0.8	1.0	1.7	0.6	1.2	1.0	-1.0	0.9	0.7	1.3
Bone: trabecular thickness	0.7	0.9	2.8	-0.8	-1.7	-0.7	0.7	-0.7	-0.4	-1.0
Bone: trabecular tissue density	0.3	0.4	0.9	1.0	0.1	-0.8	-0.4	0.4	-0.8	-0.5
Breakpoint value in progressive ratio session	0.3	0.3	1.3	-0.1	-1.2	-0.5	-0.4	0.3	-0.4	-0.5
Distance traveled before self-admin	0.7	0.7	3.5	1.9	1.1	-0.2	-0.0	-0.3	-0.3	0.2
Distance traveled after self-admin	2.0	2.3	7.2	1.0	2.7	1.4	0.7	-1.0	1.3	1.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.8	0.1	0.9	0.5	-0.0	0.0	0.4	0.6
Delta time in open arm before/after self-admin	1.1	1.0	3.7	-0.3	0.7	0.0	1.7	-1.9	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	-0.3	-1.0	-0.0	-0.8	1.0	-0.0	-0.2
Extinction: sum of active levers before priming	0.6	0.6	1.5	1.1	-0.2	-0.4	-1.2	1.1	-0.6	-0.1
Active lever presses in extinction session 6	1.1	1.1	2.3	-0.8	-0.3	1.5	-0.4	0.7	1.5	1.3
Delta distance traveled before/after self-admin	2.3	2.5	4.4	-1.1	1.9	2.1	0.4	-0.3	2.0	2.0
Delta ambulatory time before/after self-admin	1.8	2.0	3.5	-0.9	1.6	1.9	0.5	-0.4	1.8	1.8
Time in closed arm before self-admin	0.3	0.4	0.7	-0.1	-0.9	-0.8	0.2	-0.1	-0.8	-0.8
Time in closed arm after self-admin	0.2	0.2	0.6	0.8	0.6	-0.3	-0.0	-0.1	-0.4	-0.1
Time in open arm before self-admin	0.2	0.2	0.6	-0.3	-0.8	-0.1	-0.5	0.6	-0.1	-0.3
Time in open arm after self-admin	0.6	0.7	1.7	-0.9	0.3	0.5	1.2	-1.3	0.6	0.3
Sum of active levers in priming session hrs 5-6	1.5	1.5	3.7	1.1	-1.0	-0.4	-1.9	1.9	-0.6	-0.2
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.8	0.5	0.1	0.7	-1.7	1.6	0.4	0.9
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.8	1.1	0.2	0.6	-1.7	1.6	0.3	0.8
Time to tail flick, test, before self-admin	1.9	1.9	6.1	2.5	2.2	0.4	-0.9	0.5	0.1	1.1
Time to tail flick, test, after self-admin	0.7	0.7	1.1	0.9	1.0	0.8	-0.7	0.6	0.6	1.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	0.2	0.2	-0.4	0.5	0.1	0.2
Delta time to tail flick, test, before/after SA	0.6	0.5	1.9	-1.4	-1.2	0.2	0.1	0.3	0.3	-0.2
Ambulatory time before self-admin	0.5	0.5	2.3	1.5	0.9	-0.1	0.0	-0.2	-0.1	0.2
Ambulatory time after self-admin	1.5	1.6	4.7	1.0	2.2	1.3	0.2	-0.4	1.2	1.6
Total heroin consumption	1.8	2.1	8.4	-0.2	-2.9	-1.2	-0.7	0.9	-1.1	-1.5
Area under the delay curve	0.3	0.4	1.1	-0.8	-0.2	0.0	1.0	-0.9	0.2	-0.2
Delay disc. indifference point, 0s delay	0.5	0.6	1.5	-1.2	-1.2	-0.4	0.5	-0.3	-0.2	-0.8
Delay disc. indifference point, 16s delay	1.3	1.4	1.8	-0.5	1.3	1.2	1.2	-1.2	1.3	1.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.4	-0.6	-0.3	-0.1	0.3	-0.2	-0.4
Delay disc. indifference point, 24s delay	0.7	0.7	2.1	-0.4	-0.0	-0.4	1.5	-1.5	-0.2	-0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.4	0.1	0.2	0.6	-0.6	0.2	0.1
Delay disc. indifference point, 8s delay	0.6	0.7	2.0	-0.7	0.2	0.1	1.4	-1.4	0.3	-0.0
Delay discount exponential model param	0.4	0.4	1.1	0.8	0.2	-0.0	-1.0	0.9	-0.2	0.1
Delay discount hyperbolic model param	0.3	0.4	1.0	0.8	0.3	0.0	-1.0	0.9	-0.1	0.2
Fecal boli incidents, locomotor time 1	0.3	0.4	1.6	-1.3	-0.4	0.4	0.6	-0.4	0.5	0.1
Change in fecal boli incidents, locomotor task	0.6	0.5	1.4	-0.1	-1.2	-0.7	-0.6	0.6	-0.7	-0.8
Time >=10cm from walls, locomotor time 1	1.3	1.3	2.5	1.6	-0.6	-1.4	-0.5	0.2	-1.5	-1.2
Bouts of movement, locomotor time 1	0.6	0.6	0.9	-0.5	-0.8	-0.7	0.9	-0.9	-0.5	-0.9
Total resting periods, locomotor time 1	0.3	0.4	0.6	-0.2	-0.7	-0.7	0.6	-0.7	-0.5	-0.8
Rest time, locomotor task time 1	0.4	0.5	1.3	-1.1	-0.7	0.0	0.8	-0.7	0.2	-0.3
Distance moved, locomotor task time 1	0.6	0.7	2.2	1.5	0.4	-0.7	-0.7	0.5	-0.9	-0.4
Vertical activity count, locomotor time 1	0.3	0.3	0.9	0.2	1.0	0.5	0.4	-0.4	0.4	0.6
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.8	0.9	0.5	-0.2	-0.3	0.2	-0.3	0.1
Bouts of movement, locomotor time 2	0.9	0.9	1.6	1.3	-0.6	-1.1	-0.9	0.8	-1.2	-0.9
Total resting periods, locomotor time 2	0.7	0.8	1.2	1.1	-0.6	-1.0	-0.7	0.6	-1.1	-0.8
Rest time, locomotor task time 2	0.5	0.6	1.8	-0.8	-0.3	-0.1	1.3	-1.3	0.1	-0.3
Distance moved, locomotor task time 2	0.5	0.6	2.1	0.8	1.5	0.6	-0.4	0.3	0.4	0.9
Vertical activity count, locomotor time 2	1.1	1.2	2.3	-0.4	1.5	1.4	0.6	-0.4	1.3	1.4
Weight adjusted by age	1.3	1.4	3.8	1.5	0.1	0.1	-2.0	1.8	-0.2	0.5
Seeking ratio, delayed vs. immediate footshock	1.7	1.9	3.9	-0.7	1.4	2.0	0.1	0.2	1.9	1.9
Locomotion in novel chamber	1.2	1.5	3.3	-0.9	0.6	1.8	-0.1	0.2	1.7	1.7
Locomotion in novel chamber post-restriction	0.7	0.8	2.4	1.5	0.7	0.0	-1.2	1.1	-0.3	0.4
Progressive ratio	0.2	0.2	0.3	-0.4	0.2	0.6	-0.2	0.3	0.6	0.5
Food seeking constrained by brief footshock	1.7	2.0	4.0	0.2	-1.8	-1.9	0.2	-0.2	-1.7	-2.0
Seeking ratio, punishment vs. effort	1.9	2.3	4.5	0.8	-1.6	-2.1	-0.2	0.0	-2.0	-2.1
Run reversals in cocaine runway, females	0.3	0.3	0.6	-0.8	-0.7	-0.2	0.6	-0.5	-0.0	-0.4
Run reversals in cocaine runway, males	1.9	1.8	3.4	-1.6	0.0	1.8	-0.6	0.7	1.8	1.6
Latency to leave start box in cocaine runway	1.3	1.4	3.4	1.0	0.6	0.8	-1.7	1.8	0.5	1.1
Latency to leave start box in cocaine runway, F	2.2	2.4	6.2	1.5	0.6	0.8	-2.4	2.5	0.4	1.2
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	-1.0	0.2	0.5	0.8	-0.6	0.6	0.3
Cd content in liver	0.1	0.1	0.4	-0.1	-0.6	-0.4	-0.2	0.1	-0.4	-0.5
Co content in liver	0.3	0.3	0.7	-0.2	-0.6	-0.7	0.2	-0.3	-0.7	-0.8
Cu content in liver	1.5	1.8	5.6	-2.4	-0.5	0.7	1.6	-1.5	1.1	0.0
Fe content in liver	1.1	1.3	4.2	0.8	0.2	0.6	-2.1	1.8	0.2	0.9
K content in liver	1.1	1.1	2.7	-1.6	-1.6	-0.3	1.0	-0.9	0.1	-0.9
Mg content in liver	1.4	1.5	5.2	-2.3	-0.4	1.1	1.0	-1.0	1.4	0.5
Mn content in liver	0.3	0.3	0.8	0.4	-0.6	-0.2	-0.9	0.9	-0.3	-0.2
Na content in liver	0.6	0.6	2.1	-1.1	-1.5	-0.4	0.4	-0.3	-0.2	-0.9
Rb content in liver	0.2	0.2	1.1	-1.0	0.1	0.2	0.5	-0.5	0.3	0.0
Se content in liver	0.2	0.2	0.8	-0.7	-0.9	-0.2	-0.0	-0.0	-0.0	-0.5
Sr content in liver	0.0	0.0	0.1	0.4	-0.2	-0.1	-0.3	0.0	-0.2	-0.0
Zn content in liver	0.8	0.9	4.3	-2.1	-1.1	0.4	0.5	-0.2	0.6	-0.2