Hub : Genes

Tsku

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS ENSRNOT00000099039 0.04 0.04 2.9e-03 0.03 0.01 0.01 0.02 7.4e-04 3.4e-02 1.7e-02 4.0e-03
2 Adipose gene expression ENSRNOG00000027784 0.76 0.07 0.0e+00 0.48 0.52 0.51 0.51 7.4e-60 2.9e-66 3.6e-66 9.5e-65
3 Adipose isoform ratio ENSRNOT00000099039 0.08 0.07 3.6e-04 0.03 0.02 0.02 0.03 1.7e-04 2.2e-03 1.1e-03 2.4e-04
4 Adipose intron excision ratio chr1:152662698:152671518 0.03 0.03 5.0e-03 0.01 0.01 0.01 0.01 2.8e-02 7.0e-03 3.3e-02 1.9e-02
5 IL alternative TSS ENSRNOT00000034843 0.23 0.13 2.3e-03 0.09 0.04 0.03 0.05 3.6e-03 4.0e-02 7.0e-02 2.2e-02
6 Liver alternative polyA ENSRNOT00000034843 0.05 0.04 1.9e-03 0.02 0.01 0.01 0.01 2.3e-03 8.3e-03 7.4e-03 9.7e-03
7 Liver alternative polyA ENSRNOT00000114498 0.06 0.05 1.1e-03 0.02 0.01 0.01 0.01 3.2e-03 3.2e-02 6.3e-02 3.0e-02
8 Liver alternative TSS ENSRNOT00000034843 0.03 0.02 5.0e-03 0 0 -0 -0 1.9e-01 1.0e-01 6.5e-01 3.8e-01
9 Liver gene expression ENSRNOG00000027784 0.15 0.1 2.6e-05 0.02 0.03 0.03 0.03 6.0e-03 4.1e-04 1.3e-04 2.0e-04
10 Liver intron excision ratio chr1:152662698:152670303 0.21 0.11 1.2e-13 0.11 0.09 0.08 0.11 2.0e-12 1.5e-10 5.4e-09 6.5e-12
11 Liver intron excision ratio chr1:152662698:152671336 0.11 0.06 6.0e-11 0.04 0.09 0.09 0.08 5.7e-05 1.0e-09 4.8e-10 1.4e-09
12 Liver intron excision ratio chr1:152662698:152671435 0.33 0.14 1.3e-06 0.01 0.01 0.01 0.01 2.2e-02 1.1e-02 5.4e-02 1.3e-02
13 Liver intron excision ratio chr1:152662698:152671518 0.12 0.07 5.0e-10 0.09 0.07 0.08 0.08 1.4e-10 2.2e-08 6.2e-09 2.7e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail0.31.14.60.70.30.71.1-1.9-0.0-0.1-1.1-2.1-0.1-1.2-0.90.1
BMI without tail1.83.913.60.5-1.70.53.1-2.70.8-0.9-2.9-3.71.2-1.1-1.8-1.0
Body weight0.93.613.00.1-1.30.12.9-2.31.2-1.3-2.9-3.61.0-0.9-2.0-1.1
Epididymis fat weight1.02.311.40.4-0.10.42.0-2.7-0.10.0-1.7-3.4-0.2-1.9-0.50.1
Glucose0.10.20.4-0.6-0.1-0.60.10.40.5-0.6-0.10.1-0.00.30.0-0.5
Heart weight0.81.12.1-0.9-1.1-0.90.61.11.1-1.1-0.80.41.41.3-1.3-0.9
Left kidney weight1.33.87.1-1.8-2.5-1.82.7-0.12.0-2.0-2.6-1.71.80.9-1.7-2.1
Right kidney weight0.82.34.5-1.4-2.0-1.42.1-0.11.6-1.7-2.1-1.41.30.6-1.2-1.7
Tail length3.09.020.2-1.9-3.9-1.94.5-0.92.8-2.8-4.4-3.32.90.8-2.9-3.1
Length with tail1.24.310.7-1.0-2.5-1.03.3-1.12.0-1.9-3.2-2.81.60.1-2.0-2.0
Length without tail0.20.51.30.51.10.5-0.9-0.1-0.40.50.80.3-1.0-0.50.60.7
Liver weight, left0.30.52.50.3-0.10.31.0-1.00.0-0.1-0.8-1.6-0.3-0.8-0.20.1
Liver weight, right1.32.18.01.30.41.31.2-2.7-0.50.4-1.0-2.8-1.0-2.10.20.6
Parametrial fat weight0.51.03.01.50.31.50.7-1.5-0.10.1-0.7-1.7-0.1-1.1-0.80.4
Retroperitoneal fat weight2.58.433.61.90.51.92.8-5.6-1.41.2-2.2-5.8-1.3-4.20.31.4
Intraocular pressure0.50.72.5-1.6-0.3-1.6-0.21.10.4-0.30.11.10.61.0-0.3-0.4
Extensor digitorum longus weight0.31.14.6-0.6-0.6-0.61.6-1.5-0.0-0.0-1.4-2.20.4-0.9-0.60.2
Soleus weight0.51.45.2-0.3-1.1-0.31.9-1.90.2-0.1-1.7-2.30.5-0.9-0.5-0.2
Tibialis anterior weight0.10.51.1-0.3-0.7-0.30.9-0.20.6-0.7-1.0-0.90.80.1-1.1-0.5
Tibia length0.71.94.2-1.1-0.9-1.1-0.22.01.5-1.4-0.31.41.62.0-1.7-1.5
Number of licking bursts3.33.97.31.92.11.9-0.8-2.4-2.12.11.1-1.4-2.2-2.71.82.3
Food consumed during 24 hour testing period2.42.97.5-1.8-1.9-1.80.12.71.4-1.4-0.22.31.32.5-0.1-1.9
Times rat made contact with spout0.20.20.50.3-0.40.30.6-0.7-0.40.4-0.3-0.6-0.4-0.60.70.1
Mean time between licks in bursts5.37.411.4-3.0-3.4-3.02.81.23.1-3.1-2.9-0.82.62.2-2.3-3.3
Mean num. licks in bursts2.93.55.8-1.9-2.3-1.91.12.01.9-1.9-1.31.12.12.4-1.6-2.1
Std. dev. time between licks in bursts1.31.63.3-0.9-1.8-0.91.7-0.01.3-1.3-1.7-0.91.20.7-1.0-1.6
Water consumed over 24 hours1.11.32.91.00.81.0-0.7-0.8-1.41.41.00.1-1.4-1.11.71.2
Indifference point 0 sec4.47.211.8-2.1-2.8-2.11.62.43.1-3.2-2.20.83.43.2-3.4-3.0
Indifference point AUC0.20.20.4-0.3-0.6-0.30.6-0.30.3-0.3-0.7-0.60.50.1-0.6-0.3
Indifference point function ln k0.81.13.2-0.8-0.5-0.8-0.41.81.0-1.00.11.50.81.6-0.8-1.0
Indifference point function log k0.81.13.2-0.8-0.5-0.8-0.41.81.0-1.00.11.50.81.6-0.8-1.0
Delay discounting total patch changes 0 sec3.65.99.8-1.9-2.5-1.91.42.22.8-2.9-1.90.83.12.9-3.1-2.7
Delay discounting total patch changes 12 sec1.62.14.0-1.1-1.9-1.11.60.21.4-1.4-1.8-0.72.01.0-1.9-1.4
Delay discounting total patch changes 18 sec2.23.05.2-1.7-2.3-1.71.80.71.8-1.8-1.9-0.42.11.5-1.9-1.9
Delay discounting total patch changes 24 sec0.81.01.5-0.9-1.1-0.91.10.31.2-1.2-1.2-0.50.90.7-1.0-1.2
Delay discounting total patch changes 6 sec0.81.24.0-0.3-1.1-0.30.31.11.1-1.1-0.70.61.91.5-2.0-0.9
Delay discounting time to switch 0 sec4.06.18.62.42.72.4-1.8-1.9-2.92.82.2-0.4-2.9-2.82.92.8
Delay discounting water rate 0 sec3.04.86.6-2.2-2.2-2.21.32.02.5-2.5-1.70.72.62.6-2.5-2.5
Delay discounting water rate 12 sec1.82.84.9-1.6-1.7-1.60.72.01.8-1.9-0.91.21.82.2-1.5-2.0
Delay discounting water rate 18 sec0.81.11.7-1.3-1.2-1.30.90.81.1-1.1-1.00.11.11.1-0.8-1.2
Delay discounting water rate 24 sec0.60.82.4-1.0-0.5-1.0-0.31.50.6-0.70.21.40.81.4-0.4-0.8
Delay discounting water rate 6 sec0.50.71.8-0.9-0.7-0.9-0.21.40.6-0.6-0.01.21.01.2-0.6-0.7
Locomotor activity0.91.43.4-0.5-1.8-0.50.81.11.3-1.3-0.90.51.41.4-0.8-1.6
Locomotor testing distance2.43.96.5-1.6-2.5-1.62.01.02.3-2.4-2.1-0.52.31.8-2.1-2.5
Locomotor testing rearing1.42.24.3-0.5-1.8-0.52.1-0.51.7-1.7-2.1-1.51.50.6-1.7-1.7
Light reinforcement 11.42.54.32.01.72.0-0.6-1.8-1.61.60.8-1.1-1.7-2.11.11.7
Light reinforcement 20.20.20.60.80.70.8-0.70.4-0.00.00.50.3-0.40.0-0.10.2
Reaction time number correct0.60.82.81.00.71.0-1.41.1-0.40.51.21.7-0.40.50.40.3
Reaction time mean minus median1.41.83.1-0.8-1.7-0.81.30.71.6-1.6-1.5-0.31.71.2-1.8-1.6
Reaction time mean minus median AUC1.41.73.0-0.7-1.5-0.70.81.21.7-1.7-1.10.31.51.6-1.7-1.6
Reaction time num false alarms1.82.45.31.51.41.5-0.2-2.3-1.71.70.5-1.5-1.3-2.31.11.7
Reaction time num false alarms AUC1.11.53.11.01.21.0-0.4-1.6-1.51.50.6-0.9-1.2-1.71.31.4
Reaction time trials correct on left0.60.82.81.00.71.0-1.41.1-0.40.51.21.7-0.40.50.40.3
Reaction time trials on left0.60.82.91.00.71.0-1.41.2-0.40.41.21.7-0.40.50.40.3
Reaction time mean0.10.20.80.30.10.30.4-0.60.3-0.3-0.4-0.9-0.1-0.4-0.30.0
Reaction time mean AUC0.10.20.50.40.50.40.1-0.6-0.00.00.0-0.7-0.6-0.70.20.3
Median of all reaction times0.20.30.70.60.70.6-0.1-0.7-0.20.30.2-0.7-0.8-0.80.40.6
Reaction time omissions0.10.20.8-0.30.1-0.30.4-0.40.4-0.4-0.5-0.90.1-0.3-0.5-0.1
Reaction time false alarm rate1.11.54.40.61.10.60.2-2.1-1.21.20.1-1.7-1.0-2.00.91.3
Reaction time premature initiation rate2.63.57.0-1.1-2.3-1.12.5-0.61.7-1.7-2.7-1.92.20.7-2.5-1.6
Reaction time premature initiations1.41.94.4-0.7-1.8-0.71.60.21.4-1.4-1.8-0.81.91.0-2.1-1.3
Std. dev. reaction times1.11.52.8-0.7-1.4-0.71.6-0.21.3-1.4-1.7-1.21.20.5-1.5-1.2
Reaction time trials completed0.60.82.91.00.71.0-1.41.2-0.40.41.21.7-0.40.50.40.3
Reaction time trials AUC0.40.62.20.90.50.9-1.21.1-0.20.31.01.5-0.30.50.20.2
Social response proportion0.40.51.01.00.61.0-0.2-0.8-0.40.50.3-0.5-1.0-0.80.70.5
Social responses0.60.82.90.70.20.70.6-1.7-0.60.6-0.4-1.6-0.6-1.30.40.6
Social time3.03.96.92.12.52.1-1.6-1.4-2.02.01.8-0.3-2.6-2.12.12.1
Conditioned locomotion0.10.10.50.10.20.1-0.50.4-0.30.30.60.7-0.10.10.40.2
Cocaine response after cond. corrected0.70.82.00.11.10.1-0.0-1.3-0.50.50.2-1.2-1.4-1.40.90.8
Cocaine response after cond. not corrected0.20.31.10.11.00.1-0.4-0.5-0.00.00.4-0.4-1.0-0.60.40.4
Cocaine response before conditioning0.70.82.90.1-0.20.1-0.81.60.7-0.70.51.70.71.4-0.5-0.7
Saline control response1.92.64.4-1.4-1.8-1.41.41.12.1-2.1-1.6-0.21.51.6-1.6-2.1
Condit. Reinf. active minus inactive responses6.37.812.9-2.9-2.7-2.92.31.43.3-3.3-2.9-0.73.22.5-3.6-3.1
Condit. Reinf. active-inactive response ratio1.11.12.4-1.6-0.7-1.60.90.41.2-1.2-1.1-0.61.00.7-1.3-1.0
Condit. Reinf. active responses9.413.120.1-3.6-3.7-3.63.21.84.4-4.4-3.8-1.04.13.2-4.5-4.1
Condit. Reinf. inactive responses6.27.711.6-2.3-3.4-2.32.51.53.4-3.4-2.9-0.43.22.7-3.1-3.4
Condit. Reinf. lever presses17.023.433.6-4.7-4.9-4.72.84.55.8-5.8-3.71.25.65.6-5.6-5.5
Condit. Reinf. lever reinforcers received10.014.021.7-3.7-3.8-3.73.12.04.5-4.6-3.8-0.84.33.4-4.7-4.3
Pavlov. Cond. lever latency16.722.932.95.04.65.0-2.6-4.6-5.75.73.5-1.3-5.5-5.55.45.4
Pavlov. Cond. magazine entry latency3.94.57.5-2.0-1.7-2.00.52.52.5-2.5-1.11.12.62.7-2.7-2.1
Pavlov. Cond. change in total contacts11.115.524.0-3.9-3.5-3.92.03.84.9-4.9-2.91.04.54.6-4.7-4.5
Pavlov. Cond. index score12.716.623.9-4.2-3.8-4.22.04.04.9-4.9-2.91.14.74.8-4.8-4.5
Pavlov. Cond. latency score11.414.420.7-3.8-3.5-3.81.73.94.5-4.5-2.61.24.44.5-4.5-4.2
Pavlov. Cond. lever contacts17.424.234.7-4.9-4.8-4.92.74.75.9-5.9-3.71.35.85.7-5.7-5.5
Pavlov. Cond. magazine entry number6.17.511.53.42.23.4-1.2-2.8-3.23.21.7-0.9-3.0-3.23.02.9
Pavlov. Cond. intertrial magazine entries0.50.62.10.0-1.10.01.5-0.90.3-0.3-1.3-1.30.4-0.4-0.4-0.5
Pavlov. Cond. lever-magazine prob. diff.12.115.622.8-4.1-3.7-4.12.03.84.8-4.8-2.90.94.54.6-4.7-4.4
Pavlov. Cond. response bias17.424.033.6-5.1-4.8-5.12.64.65.8-5.8-3.61.35.85.7-5.6-5.5
Conditioned reinforcement - actives1.61.53.7-1.4-0.8-1.4-0.21.91.3-1.1-0.11.51.11.8-0.8-1.1
Conditioned reinforcement - inactives0.20.20.7-0.20.4-0.2-0.4-0.0-0.40.50.50.3-0.6-0.30.90.5
Conditioned locomotion1.31.63.7-1.6-0.6-1.6-0.31.91.3-1.20.01.50.81.7-0.7-1.2
Intermittent access intake day 1-15 change1.41.43.7-1.2-0.9-1.2-0.21.91.1-1.1-0.11.51.11.8-0.8-1.1
Intermittent access intake escalation1.91.84.4-1.4-1.1-1.4-0.12.11.4-1.3-0.21.61.32.0-1.0-1.3
Intermittent access intake escalation 20.60.61.0-0.9-0.8-0.90.20.90.7-0.7-0.40.61.01.0-0.7-0.7
Intermitt. access day 1 inactive lever presses0.40.41.1-0.10.7-0.1-0.3-0.7-0.70.70.5-0.2-0.8-0.81.00.7
Intermitt. access day 15 inactive lever presses0.20.20.5-0.50.5-0.5-0.50.2-0.20.30.50.4-0.6-0.10.70.3
Intermitt. access escalation Index0.10.10.20.5-0.10.5-0.10.1-0.20.10.10.20.30.1-0.10.1
Intermittent access day 1 total infusions0.80.91.5-1.2-1.1-1.20.90.51.0-0.9-0.9-0.01.10.8-0.8-0.9
Intermittent access day 15 total infusions1.92.24.0-1.9-1.3-1.90.22.01.5-1.4-0.51.41.52.0-0.9-1.4
Intermittent access terminal intake (last 3 days)1.51.63.1-1.8-1.3-1.80.51.31.3-1.1-0.70.71.51.5-1.0-1.1
Intermittent access total infusions0.80.91.9-1.4-1.0-1.40.60.81.0-0.9-0.70.31.11.0-0.7-0.9
Intermittent access day 1 locomotion0.10.10.2-0.30.1-0.3-0.30.3-0.10.10.30.50.10.20.20.1
Intermittent access day 15 total locomotion1.41.42.3-1.5-1.0-1.50.41.51.4-1.3-0.60.81.11.5-0.9-1.3
Intermittent access total locomotion0.70.81.7-1.3-0.8-1.30.60.61.0-0.9-0.70.10.90.8-0.7-0.9
Intermittent access standard deviation0.20.20.5-0.7-0.4-0.70.40.10.6-0.4-0.4-0.20.50.3-0.2-0.4
Cocaine induced anxiety2.02.33.61.51.61.5-0.9-1.5-1.71.71.2-0.4-1.9-1.81.71.7
Post-drug Anxiety0.40.50.90.50.70.5-0.5-0.5-0.80.80.6-0.0-0.9-0.81.00.8
Baseline Anxiety2.22.33.7-1.9-1.6-1.90.71.71.6-1.6-0.90.81.71.9-1.3-1.6
Lifetime Intake1.01.12.1-1.4-1.1-1.40.61.01.1-1.0-0.70.51.31.2-0.7-1.0
Incentive Sensitization - Responses3.73.76.7-2.6-2.1-2.61.71.02.0-2.0-1.9-0.22.11.7-1.8-2.0
Incentive Sensitization - Breakpoint3.53.56.6-2.6-2.0-2.61.61.12.0-1.9-1.8-0.12.01.7-1.8-1.9
Progressive ratio test 1 active lever presses0.20.20.30.20.50.2-0.5-0.1-0.50.50.50.2-0.5-0.40.60.5
Progressive ratio test 1 breakpoint0.20.20.30.30.40.3-0.5-0.2-0.50.60.50.2-0.3-0.40.50.6
Progressive ratio test 1 inactive lever presses0.10.10.5-0.7-0.4-0.70.20.10.2-0.1-0.20.00.50.2-0.1-0.1
Progressive ratio test 2 active lever presses2.22.45.6-2.4-1.5-2.41.30.81.7-1.6-1.4-0.21.51.2-1.2-1.6
Progressive ratio test 2 breakpoint1.82.04.4-2.1-1.5-2.11.30.61.5-1.4-1.4-0.21.51.2-1.3-1.4
Progressive ratio test 2 inactive lever presses1.01.13.3-1.8-1.1-1.80.90.51.1-1.0-0.9-0.01.00.8-0.6-1.0
Total sessions with >9 infusions1.41.63.2-1.0-1.3-1.00.21.71.4-1.3-0.51.01.61.8-1.4-1.3
Short access day 1 total inactive lever presses0.10.20.6-0.80.2-0.80.10.10.00.00.10.1-0.4-0.10.70.0
Short access day 10 total inactive lever presses0.20.20.50.70.60.7-0.5-0.2-0.50.50.50.2-0.4-0.40.50.5
Short access day 1 total infusions2.12.33.7-1.4-1.7-1.40.91.51.8-1.7-1.10.61.91.8-1.4-1.7
Short access day 10 total infusions0.70.71.3-1.0-1.0-1.00.80.41.0-0.9-0.9-0.11.10.7-0.8-0.9
Short access total infusions0.50.61.4-0.8-0.9-0.80.60.60.8-0.8-0.70.21.20.8-0.7-0.8
Short access day 1 locomotion1.61.75.1-1.2-0.6-1.2-0.62.21.1-1.00.32.01.12.0-0.8-1.0
Short access day 10 total locomotion0.30.30.5-0.6-0.5-0.60.40.20.7-0.6-0.5-0.10.60.5-0.6-0.6
Short access total locomotion0.10.10.3-0.1-0.0-0.1-0.40.50.1-0.10.20.60.40.5-0.2-0.1
Compulsive drug intake0.00.00.10.20.30.2-0.20.10.1-0.10.10.0-0.30.0-0.1-0.1
One hour access (0.3 mA shock)2.12.55.0-2.2-1.6-2.21.21.01.7-1.6-1.40.11.71.5-1.4-1.6
One hour access (shock baseline)1.61.83.6-1.9-1.4-1.90.81.11.4-1.3-0.90.61.51.5-1.0-1.3
Number of responses in last shaping day0.40.41.3-0.0-0.6-0.01.0-0.90.2-0.2-0.9-1.10.6-0.3-0.5-0.2
Context. condit. distance diff. score1.11.43.1-1.3-1.0-1.30.31.20.9-0.9-0.60.81.81.6-1.7-0.8
Locomotion velocity, session 10.70.72.3-0.40.8-0.4-1.00.9-0.30.21.21.2-1.10.11.50.2
Locomotion distance, session 10.40.51.4-0.60.2-0.6-0.51.20.9-0.90.30.90.11.0-0.3-0.8
Locomotion velocity, session 20.50.51.6-1.3-0.5-1.30.40.70.7-0.6-0.10.5-0.20.60.7-0.9
Locomotion distance, session 20.20.30.7-0.5-0.3-0.50.10.80.7-0.7-0.20.40.10.7-0.0-0.8
Locomotion velocity, session 30.20.20.4-0.6-0.1-0.6-0.10.60.5-0.50.00.50.20.6-0.0-0.6
Locomotion distance, session 30.40.51.5-0.90.0-0.9-0.41.20.5-0.60.31.00.40.9-0.2-0.5
Stereotopy head waving bouts, day 30.30.31.31.10.01.1-0.1-0.5-0.30.30.2-0.1-0.5-0.50.70.1
Stereotopy head waving duration, day 30.20.30.80.0-0.60.0-0.10.80.4-0.40.00.90.40.8-0.2-0.6
Locomotion velocity, session 70.20.30.5-0.10.7-0.1-0.2-0.5-0.50.60.4-0.3-0.6-0.70.60.7
Locomotion distance, session 70.20.20.8-0.60.2-0.60.5-0.60.1-0.1-0.4-0.9-0.1-0.4-0.20.2
Stereotopy head waving bouts, day 70.91.02.9-0.5-0.9-0.5-0.31.70.9-1.00.11.60.91.6-0.4-1.2
Stereotopy head waving duration, day 71.61.93.7-1.2-1.5-1.20.41.81.5-1.5-0.61.31.41.9-0.9-1.7
Locomotion velocity, session 81.41.73.8-1.9-1.3-1.90.41.61.0-0.9-0.51.11.51.7-0.9-0.9
Locomotion distance, session 81.01.53.0-1.4-1.0-1.40.31.51.3-1.3-0.60.91.31.7-1.2-1.3
Degree of sensitization distance0.80.83.30.0-0.50.01.4-1.40.3-0.2-1.3-1.80.3-0.7-0.7-0.0
Degree of sensitization stereotypy2.42.66.3-1.5-1.2-1.5-0.32.51.6-1.6-0.12.01.52.4-1.0-1.8
Condit. Reinf. active minus inactive responses0.60.72.20.0-0.60.01.2-1.00.5-0.5-1.2-1.50.7-0.3-1.0-0.3
Condit. Reinf. active-inactive response ratio0.91.02.7-0.1-1.1-0.11.4-0.60.7-0.7-1.5-1.21.30.2-1.6-0.6
Condit. Reinf. active responses0.20.31.30.3-0.10.30.7-1.00.1-0.1-0.7-1.20.0-0.6-0.3-0.0
Condit. Reinf. inactive responses0.20.20.70.10.50.1-0.2-0.3-0.30.40.3-0.1-0.8-0.50.80.2
Incentive salience index mean0.40.51.6-0.3-0.6-0.31.1-0.80.4-0.4-1.0-1.30.4-0.3-0.6-0.3
Condit. Reinf. lever presses0.10.10.5-0.7-0.4-0.70.4-0.10.00.0-0.2-0.1-0.10.00.5-0.2
Time in familiar zone, hab. session 10.10.10.2-0.10.1-0.10.0-0.3-0.40.50.1-0.1-0.3-0.30.40.5
Time in novel zone, hab. session 10.20.20.80.2-0.00.20.4-0.70.1-0.1-0.5-0.90.1-0.4-0.4-0.1
Total zone transitions, hab. session 10.40.61.91.00.41.0-1.10.80.00.00.91.40.20.7-0.30.1
Total locomotion distance, hab. session 11.11.64.52.00.52.00.4-2.1-0.60.6-0.3-1.7-0.7-1.50.00.7
Locomotion velocity, hab. session 10.81.23.92.00.42.00.3-1.8-0.40.5-0.3-1.4-0.4-1.2-0.20.5
Time in familiar zone, hab. session 21.11.13.1-1.2-1.7-1.21.20.30.6-0.6-1.2-0.11.50.9-1.0-0.9
Time in novel zone, hab. session 20.20.21.30.21.10.2-0.50.00.1-0.20.5-0.2-0.9-0.40.40.1
Total zone transitions, hab. session 20.70.92.10.20.10.2-0.81.41.1-1.00.31.30.91.4-1.3-0.7
Total locomotion distance, hab. session 20.60.82.61.30.21.30.6-1.50.00.1-0.7-1.60.0-0.9-0.80.2
Locomotion velocity, hab. session 20.70.93.01.40.21.40.6-1.60.00.1-0.7-1.7-0.0-1.0-0.70.2
Novel to familiar place preference ratio0.10.10.50.20.30.2-0.30.50.6-0.70.00.20.10.3-0.5-0.4
Novelty place preference0.10.10.4-0.00.3-0.0-0.20.40.5-0.70.00.1-0.00.2-0.3-0.4
Time in novel zone, NPP test0.20.20.6-0.30.1-0.3-0.10.50.6-0.8-0.10.10.20.4-0.4-0.6
Total zone transitions, NPP test0.20.31.00.10.60.1-1.00.80.3-0.20.71.0-0.10.5-0.1-0.0
Total locomotion distance, NPP test1.01.43.91.41.11.40.1-2.0-0.50.5-0.1-1.9-1.1-1.70.20.8
Locomotion velocity, NPP test1.31.94.81.71.41.7-0.0-2.2-0.70.70.1-2.0-1.4-2.00.51.0
Pavlov. Cond. lever latency0.91.22.51.61.51.6-0.9-0.8-1.01.00.9-0.4-1.1-1.20.41.1
Pavlov. Cond. magazine entry latency2.22.94.4-1.7-1.8-1.71.50.81.9-2.0-1.8-0.42.01.6-2.1-1.8
Pavlov. Cond. change in total contacts0.90.92.4-1.5-0.8-1.50.80.61.1-1.1-0.8-0.10.70.8-0.6-1.0
Pavlov. Cond. index score2.33.04.8-2.2-2.2-2.21.80.81.8-1.8-1.8-0.31.81.6-1.4-1.9
Pavlov. Cond. latency score2.22.84.4-2.1-2.1-2.11.60.81.7-1.8-1.7-0.21.81.6-1.5-1.8
Pavlov. Cond. lever contacts1.01.22.8-1.7-1.5-1.71.20.30.9-0.9-1.1-0.10.80.8-0.2-1.2
Pavlov. Cond. magazine entry number2.63.34.42.02.02.0-1.5-1.0-2.02.11.80.2-2.1-1.82.02.0
Pavlov. Cond. intertrial magazine entries1.41.63.71.01.41.0-0.7-1.0-1.21.31.0-0.4-1.8-1.61.91.2
Pavlov. Cond. lever-magazine prob. diff.1.92.34.2-2.0-2.0-2.01.60.71.5-1.5-1.5-0.11.61.4-1.1-1.6
Pavlov. Cond. response bias0.80.91.8-1.3-1.3-1.31.10.20.9-1.0-1.0-0.30.90.7-0.5-1.1
Bone: apparent density0.10.20.60.7-0.00.7-0.2-0.2-0.80.70.30.20.2-0.30.20.8
Bone surface1.12.04.2-1.4-1.9-1.41.30.91.3-1.4-1.4-0.02.11.3-1.7-1.2
Bone volume0.61.02.4-1.0-1.5-1.01.30.20.7-0.8-1.3-0.41.50.7-1.1-0.8
Bone: connectivity density0.10.21.00.2-0.30.2-0.40.8-0.40.30.41.00.60.5-0.10.4
Bone: cortical apparent density0.50.71.40.70.50.7-0.0-1.2-0.91.00.3-0.5-1.0-1.11.10.8
Bone: cortical area0.91.44.0-0.6-1.0-0.61.5-0.51.1-1.1-1.7-1.51.60.2-2.0-0.7
Bone: cortical porosity0.80.92.2-0.4-0.4-0.4-0.51.51.2-1.00.21.40.71.5-0.6-1.1
Bone: cortical porosity0.60.72.0-0.3-0.2-0.3-0.61.40.9-0.80.41.40.31.2-0.1-0.9
Bone: cortical thickness0.20.41.10.70.50.70.1-1.0-0.30.5-0.1-0.9-0.1-0.8-0.30.7
Bone: cortical thickness0.20.20.5-0.60.4-0.60.0-0.00.7-0.6-0.2-0.40.10.2-0.7-0.3
Bone: cortical tissue density0.50.71.50.70.50.7-0.1-1.1-0.91.00.4-0.4-1.1-1.01.20.9
Bone: elastic displacement1.41.62.81.11.51.1-1.0-0.9-1.51.51.1-0.3-1.3-1.41.11.7
Bone: elastic work1.92.44.11.11.91.1-1.7-0.5-1.81.91.80.3-1.6-1.41.82.0
Bone: endosteal estimation1.53.25.2-1.8-2.3-1.82.20.21.8-1.9-2.3-1.22.01.1-1.8-1.9
Bone: endosteal perimeter2.24.67.1-2.3-2.7-2.32.31.12.1-2.5-2.4-0.52.61.8-2.1-2.3
Bone: final force0.10.10.90.2-0.10.20.0-0.00.1-0.2-0.2-0.20.80.1-1.00.2
Bone: final moment0.10.21.2-0.0-0.4-0.00.20.10.3-0.3-0.4-0.11.00.3-1.1-0.0
Bone: marrow area1.32.84.6-1.6-2.1-1.62.10.11.6-1.8-2.1-1.21.90.9-1.7-1.7
Bone: maximum diameter2.44.58.3-1.8-2.3-1.82.10.82.3-2.5-2.4-0.92.81.6-2.9-2.1
Bone: maximum force0.10.21.1-0.1-0.3-0.10.00.30.3-0.3-0.20.11.00.5-1.00.0
Bone: maximum moment0.20.41.5-0.4-0.6-0.40.20.50.5-0.5-0.40.11.20.6-1.1-0.2
Bone: minimum diameter1.01.94.9-0.8-1.6-0.82.2-0.90.9-1.1-2.1-2.11.4-0.2-1.4-0.9
Bone: periosteal estimation1.83.66.0-1.8-2.1-1.82.30.01.9-2.1-2.4-1.52.21.0-2.3-1.8
Bone: periosteal perimeter1.93.25.5-1.6-2.3-1.62.00.81.7-1.9-2.1-0.52.41.4-2.0-1.8
Bone: post-yield work0.30.41.2-0.0-0.8-0.00.10.80.3-0.4-0.20.71.11.0-0.8-0.3
Bone: stiffness0.10.10.40.60.30.6-0.2-0.3-0.10.10.0-0.20.2-0.2-0.70.5
Bone: tissue strength1.41.33.31.41.31.4-1.80.4-1.01.11.61.4-0.5-0.10.41.2
Bone: trabecular number1.11.73.51.41.01.4-0.9-0.8-1.91.81.10.1-0.8-1.31.11.9
Bone: trabecular spacing0.91.22.3-1.1-0.7-1.10.21.51.4-1.5-0.40.90.71.5-0.8-1.5
Bone: trabecular thickness0.30.31.50.1-0.20.10.7-1.0-0.40.3-0.6-1.2-0.0-0.8-0.00.4
Bone: trabecular tissue density0.50.72.71.00.41.00.4-1.7-0.30.3-0.3-1.5-0.7-1.10.10.4
Breakpoint value in progressive ratio session0.30.30.60.50.80.5-0.6-0.2-0.60.60.70.3-0.7-0.40.60.6
Distance traveled before self-admin0.30.30.50.60.60.6-0.3-0.4-0.70.70.4-0.2-0.7-0.70.60.7
Distance traveled after self-admin1.61.82.71.31.71.3-1.6-0.2-1.31.31.60.8-1.7-0.91.51.3
Delta time in closed arm before/after self-admin0.60.62.2-0.4-0.5-0.41.2-1.4-0.20.2-0.9-1.50.0-0.90.20.2
Delta time in open arm before/after self-admin2.22.13.4-1.1-1.7-1.11.21.11.6-1.6-1.40.11.81.6-1.8-1.6
Diff in mean of infusions in LGA sessions2.93.35.22.11.92.1-0.8-2.1-1.91.91.1-1.0-2.0-2.31.71.9
Extinction: sum of active levers before priming0.10.10.4-0.30.0-0.30.5-0.50.2-0.2-0.4-0.6-0.5-0.30.2-0.2
Active lever presses in extinction session 62.01.96.1-0.8-0.7-0.8-0.62.51.4-1.40.22.11.02.3-1.0-1.4
Delta distance traveled before/after self-admin0.20.20.80.20.30.2-0.80.6-0.10.10.70.9-0.30.30.30.1
Delta ambulatory time before/after self-admin0.40.51.70.20.60.2-1.20.8-0.30.31.01.3-0.40.40.40.3
Time in closed arm before self-admin0.70.83.2-0.3-0.0-0.3-1.01.80.5-0.50.71.70.41.3-0.2-0.5
Time in closed arm after self-admin0.80.81.80.10.90.1-1.20.4-0.90.91.31.1-1.0-0.31.30.9
Time in open arm before self-admin2.22.44.21.51.61.5-0.6-2.0-1.71.70.9-0.9-1.8-2.01.61.7
Time in open arm after self-admin0.70.81.80.0-1.10.01.3-0.60.7-0.7-1.4-1.11.20.1-1.2-0.7
Sum of active levers in priming session hrs 5-60.00.00.2-0.10.3-0.1-0.0-0.10.2-0.20.0-0.1-0.4-0.10.2-0.2
Time to tail flick, vehicle, before self-admin0.40.41.20.60.30.60.2-1.1-0.60.6-0.0-0.8-0.2-0.80.20.6
Time to tail flick, vehicle, after self-admin1.21.32.5-1.1-1.1-1.10.21.61.1-1.1-0.41.01.51.6-1.1-1.1
Time to tail flick, test, before self-admin0.30.20.60.1-0.50.10.7-0.30.4-0.4-0.7-0.60.60.1-0.8-0.4
Time to tail flick, test, after self-admin0.80.81.5-1.1-0.8-1.11.2-0.10.9-0.9-1.1-0.90.60.3-0.5-0.9
Delta time to tail flick, vehicle, before/after SA2.12.06.1-1.4-1.0-1.4-0.32.51.3-1.3-0.01.91.22.1-0.9-1.3
Delta time to tail flick, test, before/after SA0.20.10.5-0.10.5-0.1-0.40.2-0.20.20.50.3-0.6-0.10.70.2
Ambulatory time before self-admin0.50.51.00.50.90.5-0.6-0.2-0.80.80.80.2-1.0-0.70.90.8
Ambulatory time after self-admin1.71.93.41.01.71.0-1.80.2-1.31.31.81.2-1.8-0.71.71.3
Total heroin consumption0.00.00.1-0.00.1-0.0-0.30.10.2-0.20.10.30.10.3-0.2-0.2
Area under the delay curve0.10.10.4-0.6-0.1-0.6-0.10.40.2-0.20.10.3-0.00.30.2-0.2
Delay disc. indifference point, 0s delay0.60.61.1-0.8-0.8-0.80.60.61.1-1.1-0.7-0.10.60.7-0.8-1.1
Delay disc. indifference point, 16s delay0.30.30.6-0.30.4-0.3-0.70.6-0.30.30.70.7-0.50.10.80.3
Delay disc. indifference point, 2s delay1.01.11.6-1.2-0.9-1.20.41.21.2-1.2-0.60.50.91.3-0.9-1.2
Delay disc. indifference point, 24s delay0.70.61.00.50.90.5-0.5-0.7-1.01.00.7-0.3-0.9-1.01.01.0
Delay disc. indifference point, 4s delay1.01.02.5-1.6-0.8-1.61.00.41.3-1.3-1.0-0.50.40.6-0.4-1.3
Delay disc. indifference point, 8s delay0.20.20.5-0.5-0.4-0.5-0.10.70.3-0.3-0.00.50.50.6-0.3-0.3
Delay discount exponential model param0.10.10.30.5-0.00.50.2-0.5-0.10.1-0.2-0.30.1-0.3-0.30.1
Delay discount hyperbolic model param0.20.20.70.80.20.8-0.1-0.6-0.40.40.1-0.3-0.1-0.4-0.00.4
Fecal boli incidents, locomotor time 10.60.71.6-1.3-0.6-1.30.01.20.7-0.7-0.10.90.51.1-0.5-0.7
Change in fecal boli incidents, locomotor task1.21.22.11.41.21.4-0.9-0.5-1.11.11.00.1-1.3-1.01.11.1
Time >=10cm from walls, locomotor time 11.11.13.2-0.7-0.6-0.7-0.21.80.9-0.9-0.01.51.01.6-1.0-0.9
Bouts of movement, locomotor time 10.10.10.3-0.60.1-0.60.10.40.5-0.5-0.10.2-0.10.4-0.1-0.5
Total resting periods, locomotor time 10.10.10.4-0.20.5-0.2-0.50.50.1-0.10.40.6-0.50.20.4-0.1
Rest time, locomotor task time 10.50.61.50.11.20.1-1.00.6-0.30.31.10.8-1.2-0.11.20.3
Distance moved, locomotor task time 11.31.42.8-1.1-1.5-1.11.7-0.80.8-0.8-1.7-1.41.40.2-1.3-0.8
Vertical activity count, locomotor time 11.21.22.9-0.7-1.5-0.71.3-0.40.8-0.8-1.5-1.01.70.5-1.6-0.8
Time >=10cm from walls, locomotor time 20.90.91.7-0.8-0.8-0.80.70.91.3-1.3-0.80.20.81.1-1.0-1.3
Bouts of movement, locomotor time 20.70.71.3-1.1-0.8-1.10.60.71.1-1.1-0.70.10.50.9-0.5-1.1
Total resting periods, locomotor time 20.30.40.8-0.9-0.5-0.90.40.60.8-0.8-0.40.20.20.6-0.2-0.8
Rest time, locomotor task time 22.12.43.82.01.72.0-1.2-1.1-1.71.71.4-0.1-1.7-1.61.61.7
Distance moved, locomotor task time 23.23.75.2-2.3-2.0-2.31.90.82.2-2.2-2.1-0.62.01.6-2.0-2.2
Vertical activity count, locomotor time 22.32.54.0-1.8-1.9-1.81.9-0.01.5-1.5-2.0-1.11.90.9-1.8-1.5
Weight adjusted by age1.41.53.3-1.2-1.3-1.21.8-0.71.2-1.1-1.7-1.61.00.1-1.0-1.2
Seeking ratio, delayed vs. immediate footshock1.51.72.90.71.40.7-0.7-1.2-1.61.51.0-0.6-1.6-1.71.71.5
Locomotion in novel chamber0.60.72.2-0.7-0.5-0.7-0.21.50.8-1.0-0.01.00.61.3-0.7-0.9
Locomotion in novel chamber post-restriction2.32.87.9-1.4-1.0-1.4-0.32.81.7-1.7-0.12.11.32.6-1.3-1.7
Progressive ratio0.10.10.3-0.10.3-0.1-0.50.4-0.10.10.50.5-0.10.2-0.00.1
Food seeking constrained by brief footshock1.82.23.5-1.0-1.7-1.01.31.01.9-1.8-1.5-0.11.61.5-1.7-1.9
Seeking ratio, punishment vs. effort1.21.52.7-0.8-1.6-0.81.50.31.5-1.4-1.6-0.71.40.9-1.4-1.4
Run reversals in cocaine runway, females1.81.86.9-0.7-1.1-0.72.2-2.10.1-0.1-1.8-2.60.6-1.0-0.5-0.1
Run reversals in cocaine runway, males0.10.10.5-0.6-0.1-0.6-0.20.5-0.10.10.30.7-0.00.30.30.1
Latency to leave start box in cocaine runway1.61.72.51.41.51.4-0.9-1.2-1.41.41.1-0.3-1.6-1.61.51.4
Latency to leave start box in cocaine runway, F0.91.02.30.91.00.9-0.2-1.4-1.01.00.4-0.9-1.1-1.51.01.1
Latency to leave start box in cocaine runway, M0.90.81.41.10.91.1-1.20.2-0.90.91.21.0-0.7-0.30.80.9
Cd content in liver0.80.82.50.70.50.70.3-1.6-0.90.9-0.1-1.4-0.7-1.40.40.9
Co content in liver1.21.42.9-1.5-1.6-1.51.7-0.01.0-1.0-1.5-1.00.90.5-0.6-1.2
Cu content in liver1.01.22.2-1.3-1.2-1.31.5-0.31.2-1.2-1.4-0.70.60.6-0.7-1.3
Fe content in liver0.10.10.4-0.70.1-0.70.4-0.40.1-0.1-0.3-0.6-0.2-0.2-0.20.1
K content in liver0.20.20.50.4-0.10.4-0.0-0.5-0.60.50.20.1-0.1-0.30.70.4
Mg content in liver0.10.20.3-0.5-0.4-0.50.20.20.3-0.4-0.30.30.50.5-0.2-0.4
Mn content in liver1.92.13.31.41.81.4-1.8-0.4-1.61.51.81.0-1.6-1.01.61.5
Na content in liver0.50.62.5-0.2-0.2-0.2-0.81.30.4-0.40.61.60.41.1-0.0-0.4
Rb content in liver0.81.01.7-1.0-1.2-1.01.20.01.0-1.0-1.2-0.11.30.9-1.0-1.1
Se content in liver4.25.18.91.92.61.9-1.9-1.4-2.62.52.20.1-3.0-2.32.92.5
Sr content in liver0.10.10.2-0.40.2-0.4-0.20.3-0.20.10.30.3-0.30.00.30.1
Zn content in liver4.34.77.0-2.0-2.3-2.01.41.62.6-2.7-1.90.42.62.5-2.6-2.6