Hub : Genes

Engase

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000027498 0.02 0.01 8.7e-03 0.01 0.01 0 0.01 4.6e-02 1.3e-02 1.6e-01 5.1e-02
2 BLA gene expression ENSRNOG00000027498 0.27 0.11 4.2e-10 0.19 0.2 0.2 0.2 1.4e-10 4.6e-11 9.7e-11 5.5e-11
3 Brain gene expression ENSRNOG00000027498 0.19 0.16 1.7e-04 0.05 0.04 0.06 0.04 2.7e-05 7.8e-05 5.9e-06 7.1e-05
4 IL gene expression ENSRNOG00000027498 0.43 0.19 1.3e-03 0.11 0.07 0.06 0.04 1.7e-03 7.2e-03 1.6e-02 4.4e-02
5 Liver gene expression ENSRNOG00000027498 0.03 0.02 1.3e-03 0.03 0.02 0.03 0.01 2.8e-04 2.1e-03 5.3e-04 1.3e-02
6 NAcc gene expression ENSRNOG00000027498 0.3 0.14 1.4e-12 0.18 0.17 0.17 0.18 1.4e-13 4.9e-13 1.3e-12 4.0e-13
7 OFC gene expression ENSRNOG00000027498 0.43 0.18 1.7e-04 0.13 0.13 0.11 0.12 4.8e-04 4.9e-04 1.4e-03 7.6e-04
8 PL gene expression ENSRNOG00000027498 0.4 0.13 0.0e+00 0.27 0.28 0.27 0.28 1.7e-20 2.9e-21 6.1e-21 1.4e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail2.06.310.1-0.1-2.7-3.2-2.62.5-2.5-2.6-2.7
BMI without tail0.30.72.21.50.50.20.7-0.90.70.70.7
Body weight1.66.911.2-1.9-3.3-0.2-2.92.8-2.8-2.9-2.8
Epididymis fat weight0.40.91.3-0.1-1.2-0.8-1.00.9-1.0-1.0-1.1
Glucose0.50.71.2-0.0-0.8-1.1-0.90.8-0.9-0.9-0.8
Heart weight2.23.23.9-0.4-1.8-2.0-1.91.9-1.9-1.9-1.9
Left kidney weight2.57.29.6-3.1-2.90.1-2.82.8-2.8-2.8-2.7
Right kidney weight1.64.46.1-2.1-2.50.4-2.32.2-2.2-2.3-2.2
Tail length1.64.917.70.41.44.21.9-2.01.91.92.1
Length with tail0.72.77.0-2.4-1.62.7-1.11.1-1.1-1.1-1.0
Length without tail4.910.613.5-3.3-3.7-0.7-3.53.5-3.4-3.5-3.5
Liver weight, left1.42.24.2-2.1-1.4-0.2-1.51.5-1.5-1.5-1.5
Liver weight, right1.52.53.6-1.6-1.9-0.0-1.61.7-1.7-1.6-1.7
Parametrial fat weight0.00.10.2-0.1-0.40.2-0.30.2-0.2-0.3-0.3
Retroperitoneal fat weight0.10.30.8-0.9-0.40.8-0.40.2-0.2-0.4-0.3
Intraocular pressure2.73.85.11.72.30.92.1-2.12.12.12.0
Extensor digitorum longus weight0.31.04.92.20.5-1.10.6-0.70.60.60.6
Soleus weight0.30.91.70.8-1.0-1.3-0.90.7-0.9-0.9-0.8
Tibialis anterior weight0.10.52.30.6-0.4-1.5-0.40.4-0.5-0.4-0.4
Tibia length8.724.545.3-6.7-5.10.7-5.05.0-5.0-5.0-4.8
Number of licking bursts0.00.10.2-0.3-0.20.5-0.10.1-0.1-0.1-0.1
Food consumed during 24 hour testing period0.91.11.5-0.11.21.11.1-1.11.11.11.2
Times rat made contact with spout0.50.60.70.60.80.70.8-0.80.80.80.8
Mean time between licks in bursts0.10.20.5-0.1-0.4-0.7-0.40.4-0.4-0.4-0.5
Mean num. licks in bursts0.40.51.01.00.9-0.40.7-0.70.70.70.7
Std. dev. time between licks in bursts2.32.73.21.41.71.11.8-1.81.81.81.8
Water consumed over 24 hours0.10.20.30.20.50.30.4-0.40.40.40.5
Indifference point 0 sec1.21.92.71.61.6-0.21.4-1.41.41.41.4
Indifference point AUC1.41.72.31.01.11.01.4-1.51.31.41.5
Indifference point function ln k1.92.86.20.1-1.4-2.5-1.61.7-1.6-1.6-1.8
Indifference point function log k1.92.86.20.1-1.4-2.5-1.61.7-1.6-1.6-1.8
Delay discounting total patch changes 0 sec1.42.23.61.91.7-0.61.5-1.51.41.51.4
Delay discounting total patch changes 12 sec2.22.94.52.11.7-0.31.8-1.81.71.81.7
Delay discounting total patch changes 18 sec5.37.19.32.13.11.22.8-3.02.72.82.9
Delay discounting total patch changes 24 sec0.81.02.00.11.4-0.11.0-1.11.11.01.2
Delay discounting total patch changes 6 sec1.11.72.91.71.3-0.51.3-1.41.31.31.3
Delay discounting time to switch 0 sec0.10.10.5-0.7-0.30.2-0.30.4-0.2-0.3-0.4
Delay discounting water rate 0 sec0.50.81.11.00.90.21.0-1.00.91.01.0
Delay discounting water rate 12 sec1.21.87.40.7-0.8-2.7-1.01.0-1.1-1.0-1.1
Delay discounting water rate 18 sec0.30.40.91.00.7-0.30.5-0.60.60.50.6
Delay discounting water rate 24 sec1.72.43.82.01.8-0.61.5-1.61.61.51.6
Delay discounting water rate 6 sec1.21.84.10.0-1.3-2.0-1.41.3-1.3-1.4-1.3
Locomotor activity0.10.11.00.20.01.00.1-0.20.30.10.2
Locomotor testing distance0.81.34.00.50.92.01.0-1.11.11.01.1
Locomotor testing rearing1.62.52.81.31.61.31.7-1.71.71.71.7
Light reinforcement 10.61.12.81.71.0-0.31.0-1.01.01.01.0
Light reinforcement 20.10.10.2-0.2-0.4-0.3-0.30.2-0.2-0.3-0.2
Reaction time number correct4.36.27.62.42.70.62.6-2.72.82.62.6
Reaction time mean minus median1.31.72.2-1.2-1.4-0.4-1.51.4-1.4-1.5-1.4
Reaction time mean minus median AUC0.91.22.1-1.4-1.1-0.0-1.11.1-1.1-1.1-1.1
Reaction time num false alarms0.10.20.30.50.50.20.4-0.40.40.40.4
Reaction time num false alarms AUC0.40.60.70.80.80.60.8-0.80.80.80.8
Reaction time trials correct on left4.36.27.62.42.70.62.6-2.72.82.62.6
Reaction time trials on left4.36.27.62.42.70.72.6-2.72.82.62.7
Reaction time mean0.10.10.2-0.3-0.40.0-0.50.3-0.4-0.5-0.4
Reaction time mean AUC0.10.10.2-0.0-0.4-0.2-0.40.4-0.4-0.4-0.4
Median of all reaction times0.00.00.1-0.1-0.20.0-0.20.1-0.2-0.2-0.1
Reaction time omissions0.40.61.2-1.1-0.80.2-0.80.8-0.8-0.8-0.7
Reaction time false alarm rate0.30.40.5-0.5-0.60.3-0.60.7-0.7-0.6-0.6
Reaction time premature initiation rate0.70.93.41.80.3-1.70.6-0.40.30.60.2
Reaction time premature initiations2.84.09.43.11.8-1.02.1-1.91.92.11.7
Std. dev. reaction times0.40.50.7-0.4-0.7-0.6-0.80.7-0.8-0.8-0.8
Reaction time trials completed4.36.27.62.42.70.72.6-2.72.82.62.7
Reaction time trials AUC4.76.78.32.62.80.72.7-2.82.92.72.8
Social response proportion0.10.10.30.5-0.3-0.0-0.20.2-0.1-0.2-0.3
Social responses0.20.20.4-0.1-0.6-0.6-0.50.5-0.3-0.5-0.5
Social time0.20.31.10.7-0.3-1.0-0.40.4-0.3-0.4-0.4
Conditioned locomotion0.40.50.50.70.70.70.6-0.70.70.60.7
Cocaine response after cond. corrected0.10.10.2-0.3-0.4-0.3-0.50.3-0.4-0.5-0.4
Cocaine response after cond. not corrected0.00.00.2-0.3-0.00.50.0-0.10.10.00.1
Cocaine response before conditioning1.21.43.10.11.01.71.3-1.11.21.31.2
Saline control response0.30.31.0-0.70.21.00.5-0.40.40.50.6
Condit. Reinf. active minus inactive responses0.40.53.0-0.60.31.70.4-0.40.50.40.5
Condit. Reinf. active-inactive response ratio0.20.21.1-0.6-0.01.0-0.0-0.10.1-0.00.1
Condit. Reinf. active responses1.01.32.00.51.21.41.2-1.11.31.21.2
Condit. Reinf. inactive responses1.41.72.21.21.50.41.5-1.31.41.51.3
Condit. Reinf. lever presses2.53.54.31.62.10.92.1-2.02.12.11.9
Condit. Reinf. lever reinforcers received1.21.72.20.91.41.21.4-1.31.51.41.3
Pavlov. Cond. lever latency3.85.26.5-1.9-2.6-1.2-2.52.4-2.5-2.5-2.4
Pavlov. Cond. magazine entry latency0.70.81.51.21.1-0.90.7-0.70.80.70.6
Pavlov. Cond. change in total contacts1.92.73.91.82.00.11.6-1.71.81.61.7
Pavlov. Cond. index score2.12.84.11.62.00.31.8-1.81.81.81.7
Pavlov. Cond. latency score1.92.53.81.42.00.21.7-1.71.71.71.6
Pavlov. Cond. lever contacts3.95.46.71.82.61.42.5-2.42.52.52.4
Pavlov. Cond. magazine entry number1.21.42.5-1.6-1.50.6-1.11.1-1.2-1.1-1.1
Pavlov. Cond. intertrial magazine entries3.03.99.80.21.63.12.0-1.91.92.02.0
Pavlov. Cond. lever-magazine prob. diff.2.53.24.71.72.20.31.9-1.91.91.91.8
Pavlov. Cond. response bias1.92.63.61.61.90.31.7-1.71.81.71.6
Conditioned reinforcement - actives0.50.41.01.00.40.80.5-0.60.60.50.6
Conditioned reinforcement - inactives0.20.20.3-0.5-0.6-0.1-0.50.5-0.6-0.5-0.5
Conditioned locomotion0.91.11.81.30.71.21.0-1.01.01.00.9
Intermittent access intake day 1-15 change0.10.10.6-0.8-0.30.2-0.30.3-0.3-0.3-0.2
Intermittent access intake escalation0.20.20.5-0.40.30.70.3-0.30.30.30.4
Intermittent access intake escalation 20.60.63.7-0.20.01.90.5-0.30.40.50.4
Intermitt. access day 1 inactive lever presses0.30.31.7-1.3-0.20.2-0.40.5-0.5-0.4-0.5
Intermitt. access day 15 inactive lever presses0.20.30.40.50.6-0.00.6-0.60.60.60.6
Intermitt. access escalation Index0.10.10.3-0.60.5-0.20.2-0.20.30.20.3
Intermittent access day 1 total infusions0.10.10.60.3-0.1-0.8-0.30.2-0.3-0.3-0.3
Intermittent access day 15 total infusions0.10.10.20.00.40.10.4-0.40.30.40.4
Intermittent access terminal intake (last 3 days)0.10.10.1-0.20.30.30.3-0.20.20.30.2
Intermittent access total infusions0.00.10.10.10.3-0.20.3-0.20.20.30.2
Intermittent access day 1 locomotion0.50.51.11.00.60.40.8-0.70.70.80.6
Intermittent access day 15 total locomotion0.10.10.7-0.1-0.40.8-0.20.2-0.3-0.2-0.2
Intermittent access total locomotion0.20.20.50.70.20.60.5-0.40.40.50.3
Intermittent access standard deviation3.23.44.9-2.2-1.9-0.8-1.82.0-2.0-1.8-2.0
Cocaine induced anxiety0.20.21.1-1.1-0.30.4-0.20.2-0.2-0.2-0.2
Post-drug Anxiety0.30.40.5-0.10.60.50.7-0.70.70.70.6
Baseline Anxiety0.00.00.20.30.0-0.40.1-0.00.10.1-0.1
Lifetime Intake0.00.00.2-0.10.0-0.5-0.00.0-0.1-0.0-0.1
Incentive Sensitization - Responses0.40.40.6-0.6-0.80.7-0.60.6-0.6-0.6-0.6
Incentive Sensitization - Breakpoint0.50.50.7-0.7-0.80.7-0.70.7-0.7-0.7-0.7
Progressive ratio test 1 active lever presses1.11.11.50.71.20.41.2-1.21.11.21.1
Progressive ratio test 1 breakpoint0.70.71.00.61.0-0.11.0-1.00.91.00.9
Progressive ratio test 1 inactive lever presses0.00.00.2-0.40.10.30.1-0.10.00.10.1
Progressive ratio test 2 active lever presses0.60.71.90.70.51.40.7-0.80.70.70.7
Progressive ratio test 2 breakpoint0.50.61.70.70.41.30.7-0.70.70.70.7
Progressive ratio test 2 inactive lever presses0.10.21.2-0.1-0.21.10.0-0.0-0.00.00.0
Total sessions with >9 infusions0.40.50.6-0.7-0.7-0.5-0.80.6-0.7-0.8-0.8
Short access day 1 total inactive lever presses0.00.00.1-0.4-0.20.3-0.10.0-0.0-0.1-0.1
Short access day 10 total inactive lever presses0.40.51.4-1.2-0.6-0.1-0.70.6-0.6-0.7-0.6
Short access day 1 total infusions0.60.61.2-0.7-0.6-1.1-0.80.7-0.7-0.8-0.7
Short access day 10 total infusions0.10.10.2-0.40.3-0.40.1-0.10.00.1-0.0
Short access total infusions0.30.31.0-0.2-0.4-1.0-0.40.4-0.5-0.4-0.5
Short access day 1 locomotion0.70.71.2-0.7-1.1-0.5-0.90.8-0.8-0.9-0.9
Short access day 10 total locomotion0.40.50.8-0.6-0.90.2-0.60.8-0.7-0.6-0.9
Short access total locomotion2.62.73.7-1.0-1.9-1.2-1.71.8-1.8-1.7-1.8
Compulsive drug intake0.10.10.50.7-0.00.30.1-0.10.20.1-0.0
One hour access (0.3 mA shock)0.70.81.10.91.00.11.0-0.90.91.00.8
One hour access (shock baseline)0.40.50.70.10.80.40.8-0.70.70.80.8
Number of responses in last shaping day1.81.92.6-1.6-1.6-0.0-1.41.4-1.4-1.4-1.4
Context. condit. distance diff. score0.20.20.4-0.00.60.10.5-0.50.50.50.5
Locomotion velocity, session 11.41.52.1-1.4-1.50.1-1.31.3-1.3-1.3-1.2
Locomotion distance, session 10.30.32.01.40.2-0.00.3-0.40.40.30.4
Locomotion velocity, session 20.10.20.60.80.2-0.60.2-0.20.20.20.2
Locomotion distance, session 21.01.46.12.50.7-0.41.0-0.91.01.00.9
Locomotion velocity, session 30.20.30.5-0.7-0.50.0-0.50.5-0.5-0.5-0.5
Locomotion distance, session 31.31.42.7-0.0-1.1-1.7-1.21.3-1.2-1.2-1.3
Stereotopy head waving bouts, day 30.30.31.1-1.0-0.3-0.1-0.50.5-0.5-0.5-0.5
Stereotopy head waving duration, day 30.10.20.8-0.90.20.60.1-0.10.10.10.1
Locomotion velocity, session 70.70.82.10.10.71.40.9-0.80.90.90.9
Locomotion distance, session 72.93.74.62.11.81.22.1-1.92.02.11.9
Stereotopy head waving bouts, day 70.70.82.8-1.7-0.5-0.5-0.90.8-0.7-0.9-0.8
Stereotopy head waving duration, day 71.11.45.4-2.3-0.7-0.1-1.11.0-1.0-1.1-1.0
Locomotion velocity, session 80.50.61.5-0.60.61.20.7-0.70.80.70.7
Locomotion distance, session 81.72.54.72.21.50.21.7-1.61.61.71.5
Degree of sensitization distance9.39.510.92.33.02.73.3-3.33.23.33.3
Degree of sensitization stereotypy0.40.51.3-1.2-0.4-0.5-0.70.6-0.6-0.7-0.6
Condit. Reinf. active minus inactive responses0.40.50.80.50.9-0.40.7-0.80.70.70.7
Condit. Reinf. active-inactive response ratio1.71.92.60.91.60.71.5-1.51.41.51.5
Condit. Reinf. active responses0.30.40.50.60.7-0.50.7-0.70.60.70.6
Condit. Reinf. inactive responses0.10.10.20.50.1-0.50.2-0.10.10.20.1
Incentive salience index mean0.20.30.60.20.7-0.50.5-0.50.50.50.5
Condit. Reinf. lever presses0.10.10.20.30.5-0.40.3-0.30.30.30.2
Time in familiar zone, hab. session 10.30.32.00.30.2-1.4-0.10.1-0.1-0.1-0.1
Time in novel zone, hab. session 10.20.21.1-0.8-0.41.1-0.10.2-0.1-0.1-0.1
Total zone transitions, hab. session 10.71.02.51.60.90.11.0-1.01.11.00.9
Total locomotion distance, hab. session 10.40.62.01.40.60.40.7-0.70.70.70.7
Locomotion velocity, hab. session 10.50.72.61.60.50.30.7-0.70.70.70.7
Time in familiar zone, hab. session 20.10.10.30.30.1-0.50.1-0.10.10.10.0
Time in novel zone, hab. session 20.00.00.3-0.5-0.0-0.0-0.10.1-0.2-0.1-0.1
Total zone transitions, hab. session 22.93.88.62.91.7-0.12.0-1.92.02.01.8
Total locomotion distance, hab. session 21.62.17.32.71.1-0.31.2-1.31.31.21.2
Locomotion velocity, hab. session 21.52.07.02.61.0-0.01.2-1.31.31.21.2
Novel to familiar place preference ratio1.91.93.71.91.5-0.11.4-1.41.41.41.3
Novelty place preference1.71.82.91.71.40.01.4-1.31.31.41.3
Time in novel zone, NPP test1.81.93.41.81.5-0.21.4-1.31.41.41.3
Total zone transitions, NPP test1.42.15.42.31.2-0.11.4-1.41.51.41.3
Total locomotion distance, NPP test1.52.08.93.01.0-0.81.1-1.11.11.11.0
Locomotion velocity, NPP test1.31.97.92.81.0-0.61.1-1.11.21.11.0
Pavlov. Cond. lever latency2.43.03.61.31.81.11.9-1.91.91.91.9
Pavlov. Cond. magazine entry latency0.70.93.0-1.7-0.71.0-0.80.7-0.8-0.8-0.6
Pavlov. Cond. change in total contacts0.50.51.60.4-0.6-1.3-0.60.6-0.6-0.6-0.7
Pavlov. Cond. index score1.21.52.3-1.5-1.2-0.0-1.31.3-1.3-1.3-1.2
Pavlov. Cond. latency score2.02.53.4-1.8-1.6-0.3-1.71.7-1.7-1.7-1.6
Pavlov. Cond. lever contacts1.51.82.2-0.6-1.3-1.5-1.41.4-1.4-1.4-1.4
Pavlov. Cond. magazine entry number1.31.63.81.91.1-0.41.3-1.21.31.31.1
Pavlov. Cond. intertrial magazine entries1.72.13.01.71.5-0.41.5-1.51.51.51.4
Pavlov. Cond. lever-magazine prob. diff.0.91.11.6-1.3-1.10.0-1.21.1-1.1-1.2-1.0
Pavlov. Cond. response bias1.01.31.8-1.4-1.1-0.2-1.21.2-1.2-1.2-1.1
Bone: apparent density2.64.35.01.82.11.62.2-2.22.22.22.2
Bone surface3.35.811.10.12.53.32.4-2.42.42.42.5
Bone volume3.45.86.91.02.62.62.5-2.52.62.52.6
Bone: connectivity density3.45.36.31.62.32.22.4-2.42.52.42.5
Bone: cortical apparent density0.60.83.11.2-0.6-1.8-0.60.5-0.5-0.6-0.6
Bone: cortical area4.77.28.6-2.0-2.9-1.6-2.92.9-2.9-2.9-2.9
Bone: cortical porosity0.60.62.0-1.4-0.60.4-0.70.7-0.7-0.7-0.6
Bone: cortical porosity0.60.62.5-1.6-0.50.5-0.60.6-0.6-0.6-0.6
Bone: cortical thickness11.018.222.9-1.5-4.8-4.1-4.54.5-4.5-4.5-4.6
Bone: cortical thickness6.67.79.3-1.0-3.1-2.8-2.92.9-2.9-2.9-3.0
Bone: cortical tissue density0.50.72.81.2-0.5-1.7-0.40.4-0.4-0.4-0.4
Bone: elastic displacement1.11.23.70.7-1.0-1.9-0.90.9-0.9-0.9-1.0
Bone: elastic work2.83.64.5-0.7-2.1-1.8-2.02.1-2.0-2.0-2.1
Bone: endosteal estimation3.47.49.60.53.13.12.8-2.82.82.82.8
Bone: endosteal perimeter1.94.011.8-1.42.03.41.6-1.71.71.61.8
Bone: final force2.13.44.4-1.6-2.1-0.8-2.02.0-1.9-2.0-2.0
Bone: final moment2.03.34.2-1.6-2.0-0.9-2.02.0-1.9-2.0-2.0
Bone: marrow area3.37.29.40.43.13.12.8-2.82.82.82.7
Bone: maximum diameter1.01.76.7-2.6-0.81.4-1.01.0-1.0-1.0-0.9
Bone: maximum force1.32.22.8-1.2-1.7-0.8-1.61.6-1.6-1.6-1.7
Bone: maximum moment1.22.12.6-1.2-1.6-0.9-1.61.6-1.5-1.6-1.6
Bone: minimum diameter0.20.41.6-1.30.31.10.0-0.00.00.00.1
Bone: periosteal estimation0.10.31.2-1.10.21.10.0-0.00.00.0-0.0
Bone: periosteal perimeter1.83.16.9-2.6-1.60.6-1.71.7-1.7-1.7-1.7
Bone: post-yield work1.01.41.91.41.40.21.2-1.21.31.21.2
Bone: stiffness1.93.03.7-1.6-1.9-0.8-1.81.9-1.9-1.8-1.9
Bone: tissue strength0.40.41.41.20.6-0.60.5-0.50.50.50.4
Bone: trabecular number1.42.22.70.81.51.31.5-1.61.61.51.6
Bone: trabecular spacing0.30.40.6-0.5-0.5-0.8-0.60.7-0.7-0.6-0.7
Bone: trabecular thickness1.21.41.61.11.20.91.2-1.21.31.21.2
Bone: trabecular tissue density0.60.81.3-0.8-1.10.0-1.01.0-1.0-1.0-1.0
Breakpoint value in progressive ratio session0.90.91.50.81.20.61.0-1.01.01.01.0
Distance traveled before self-admin0.40.51.7-1.3-0.51.0-0.40.2-0.4-0.4-0.3
Distance traveled after self-admin2.73.03.81.71.90.91.9-1.71.91.91.7
Delta time in closed arm before/after self-admin0.20.20.7-0.50.40.80.4-0.30.40.40.5
Delta time in open arm before/after self-admin0.50.40.90.90.7-0.40.6-0.70.60.60.6
Diff in mean of infusions in LGA sessions0.70.81.60.21.11.30.8-0.90.80.80.9
Extinction: sum of active levers before priming0.60.62.40.1-0.4-1.5-0.60.7-0.6-0.6-0.6
Active lever presses in extinction session 61.00.92.20.70.71.50.9-1.00.90.90.8
Delta distance traveled before/after self-admin2.12.35.02.21.5-0.51.5-1.41.51.51.4
Delta ambulatory time before/after self-admin3.13.46.02.42.0-0.21.9-1.81.91.91.8
Time in closed arm before self-admin0.80.91.5-0.3-1.2-0.7-1.00.9-1.0-1.0-1.0
Time in closed arm after self-admin1.01.11.7-1.3-1.0-0.5-1.11.1-1.1-1.1-1.1
Time in open arm before self-admin0.20.20.5-0.6-0.40.7-0.30.3-0.3-0.3-0.3
Time in open arm after self-admin0.80.91.00.80.90.91.0-1.01.01.01.0
Sum of active levers in priming session hrs 5-60.30.30.70.30.90.10.5-0.40.50.50.5
Time to tail flick, vehicle, before self-admin0.20.20.60.3-0.6-0.8-0.40.4-0.4-0.4-0.4
Time to tail flick, vehicle, after self-admin3.43.64.8-1.0-1.8-2.2-2.01.9-2.0-2.0-2.0
Time to tail flick, test, before self-admin1.01.02.10.40.81.51.0-1.01.01.01.0
Time to tail flick, test, after self-admin0.40.40.8-0.8-0.70.9-0.50.4-0.5-0.5-0.5
Delta time to tail flick, vehicle, before/after SA0.00.00.20.20.4-0.40.1-0.10.10.10.1
Delta time to tail flick, test, before/after SA2.72.42.9-1.3-1.7-0.9-1.71.6-1.7-1.7-1.7
Ambulatory time before self-admin1.11.23.0-1.7-1.01.0-1.00.9-1.0-1.0-0.9
Ambulatory time after self-admin1.41.61.91.11.31.01.4-1.21.41.41.3
Total heroin consumption0.50.61.5-1.2-0.60.2-0.80.7-0.8-0.8-0.7
Area under the delay curve0.30.31.5-1.2-0.21.1-0.1-0.0-0.0-0.10.0
Delay disc. indifference point, 0s delay1.01.12.7-1.6-1.2-0.2-1.10.9-1.0-1.1-0.9
Delay disc. indifference point, 16s delay0.70.71.00.71.00.30.9-1.01.00.90.9
Delay disc. indifference point, 2s delay0.40.53.1-0.8-0.21.80.0-0.10.10.00.1
Delay disc. indifference point, 24s delay0.10.10.10.10.2-0.00.3-0.30.30.30.3
Delay disc. indifference point, 4s delay0.50.52.1-1.5-0.51.1-0.40.3-0.3-0.4-0.3
Delay disc. indifference point, 8s delay1.21.25.1-2.3-0.71.4-0.70.6-0.6-0.7-0.5
Delay discount exponential model param0.40.41.91.40.2-1.00.2-0.10.10.20.1
Delay discount hyperbolic model param0.40.41.71.30.3-1.20.2-0.10.10.20.1
Fecal boli incidents, locomotor time 10.80.91.51.21.0-0.21.0-1.01.01.00.8
Change in fecal boli incidents, locomotor task0.30.20.80.2-0.3-0.9-0.40.5-0.4-0.4-0.4
Time >=10cm from walls, locomotor time 10.70.71.1-0.01.10.60.8-0.90.90.81.0
Bouts of movement, locomotor time 11.01.14.50.0-0.7-2.1-1.00.8-0.9-1.0-0.9
Total resting periods, locomotor time 10.80.94.30.2-0.5-2.1-0.80.6-0.7-0.8-0.7
Rest time, locomotor task time 11.21.32.5-0.3-1.1-1.6-1.11.2-1.2-1.1-1.3
Distance moved, locomotor task time 10.90.92.90.20.81.70.8-0.90.90.81.1
Vertical activity count, locomotor time 11.61.72.40.91.11.51.3-1.31.31.31.4
Time >=10cm from walls, locomotor time 20.10.10.10.2-0.40.1-0.20.2-0.3-0.2-0.2
Bouts of movement, locomotor time 20.00.00.1-0.10.3-0.30.1-0.20.10.10.1
Total resting periods, locomotor time 20.10.10.20.00.4-0.20.4-0.30.30.40.3
Rest time, locomotor task time 20.10.10.2-0.10.4-0.10.4-0.20.20.40.1
Distance moved, locomotor task time 20.70.91.7-0.4-1.30.4-1.10.9-1.0-1.1-0.9
Vertical activity count, locomotor time 20.20.20.50.1-0.70.4-0.40.4-0.5-0.4-0.5
Weight adjusted by age0.60.62.70.10.41.60.7-0.70.70.70.6
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.1-0.30.30.10.1-0.20.10.0
Locomotion in novel chamber3.44.35.31.02.31.62.3-2.32.22.32.3
Locomotion in novel chamber post-restriction1.11.32.10.21.40.91.1-1.21.51.11.3
Progressive ratio0.10.10.30.60.4-0.40.2-0.10.10.20.1
Food seeking constrained by brief footshock0.60.71.1-0.7-0.8-0.4-0.91.0-0.8-0.9-1.1
Seeking ratio, punishment vs. effort0.20.20.7-0.8-0.40.2-0.40.5-0.2-0.4-0.4
Run reversals in cocaine runway, females0.10.11.0-0.10.1-1.0-0.20.0-0.1-0.2-0.1
Run reversals in cocaine runway, males1.11.01.9-0.2-1.4-0.3-1.11.1-1.1-1.1-1.2
Latency to leave start box in cocaine runway0.10.10.50.70.1-0.60.1-0.30.20.10.2
Latency to leave start box in cocaine runway, F0.30.30.60.80.4-0.50.5-0.60.50.50.5
Latency to leave start box in cocaine runway, M0.20.21.11.00.2-0.50.2-0.20.20.20.2
Cd content in liver0.80.82.70.8-0.7-1.7-0.70.7-0.7-0.7-0.8
Co content in liver0.40.51.41.10.7-1.20.5-0.50.50.50.4
Cu content in liver0.20.30.3-0.2-0.6-0.1-0.60.6-0.6-0.6-0.6
Fe content in liver1.11.32.30.21.50.81.2-1.21.21.21.2
K content in liver0.20.20.3-0.00.50.20.4-0.40.40.40.5
Mg content in liver1.51.52.11.41.30.01.3-1.31.31.31.3
Mn content in liver0.50.61.6-1.3-0.80.7-0.60.6-0.6-0.6-0.6
Na content in liver0.10.10.4-0.70.20.60.1-0.10.10.10.2
Rb content in liver0.91.12.51.60.80.31.1-1.11.11.11.0
Se content in liver1.61.93.60.41.31.91.4-1.41.41.41.5
Sr content in liver1.21.11.3-0.4-1.1-1.1-1.11.1-1.1-1.1-1.1
Zn content in liver1.31.41.6-1.1-1.1-0.9-1.31.3-1.3-1.3-1.3