Hub : Genes

Ypel5

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	ENSRNOT00000035362	0.0348	0.0238	2.5e-05	0.052	0.045	0.045	0.049	1.7e-06	8.8e-06	8.0e-06	3.6e-06
2	Adipose	alternative polyA	ENSRNOT00000103854	0.0328	0.0225	4.1e-05	0.049	0.043	0.043	0.046	3.3e-06	1.5e-05	1.5e-05	6.9e-06
3	Adipose	gene expression	ENSRNOG00000026742	0.1900	0.1000	0.0e+00	0.232	0.236	0.234	0.232	2.3e-25	6.3e-26	1.3e-25	2.3e-25
4	Adipose	isoform ratio	ENSRNOT00000035362	0.0320	0.0220	7.8e-05	0.044	0.037	0.038	0.039	9.8e-06	5.4e-05	3.8e-05	3.1e-05
5	Adipose	isoform ratio	ENSRNOT00000101401	0.0650	0.0580	3.5e-04	0.045	0.034	0.033	0.038	9.4e-06	9.3e-05	1.3e-04	4.0e-05
6	Liver	alternative polyA	ENSRNOT00000035362	0.0394	0.0258	5.7e-06	0.045	0.043	0.038	0.041	9.0e-06	1.4e-05	3.8e-05	2.3e-05
7	Liver	alternative polyA	ENSRNOT00000103854	0.0420	0.0273	2.5e-06	0.053	0.046	0.044	0.046	1.6e-06	7.0e-06	1.1e-05	6.8e-06
8	Liver	alternative TSS	ENSRNOT00000035362	0.1188	0.0778	4.2e-06	0.060	0.048	0.049	0.051	3.2e-07	4.5e-06	3.2e-06	2.5e-06
9	Liver	alternative TSS	ENSRNOT00000103854	0.1280	0.0818	4.3e-06	0.061	0.048	0.049	0.050	2.6e-07	5.0e-06	3.2e-06	2.6e-06
10	Liver	gene expression	ENSRNOG00000026742	0.2900	0.1200	0.0e+00	0.369	0.374	0.381	0.377	5.8e-43	1.1e-43	1.4e-44	4.9e-44
11	Liver	isoform ratio	ENSRNOT00000035362	0.1529	0.0793	0.0e+00	0.193	0.206	0.215	0.210	5.6e-21	2.0e-22	1.6e-23	6.1e-23
12	Liver	isoform ratio	ENSRNOT00000101401	0.1393	0.0705	0.0e+00	0.183	0.198	0.204	0.200	7.3e-20	1.4e-21	3.4e-22	8.6e-22
13	Liver	intron excision ratio	chr6:22660590:22667194	0.0459	0.0305	1.9e-06	0.059	0.055	0.055	0.057	4.0e-07	8.6e-07	9.1e-07	6.7e-07
14	Liver	intron excision ratio	chr6:22660590:22671605	0.0721	0.0419	4.6e-11	0.102	0.102	0.097	0.102	2.0e-11	2.3e-11	6.6e-11	2.1e-11
15	Liver	intron excision ratio	chr6:22667280:22668285	0.0400	0.0290	3.6e-05	0.034	0.034	0.033	0.034	9.5e-05	9.9e-05	1.4e-04	9.5e-05
16	NAcc	gene expression	ENSRNOG00000026742	0.0270	0.0210	6.8e-03	0.000	0.005	-0.003	-0.001	3.2e-01	1.4e-01	6.6e-01	4.4e-01

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Light reinforcement 1	5.2	9.6	12.2	-3.1	3.1	2.8	-3.2	3.1	-2.7	2.7	-3.1	3.1	2.7	-3.5	3.5	3.5	-2.7	-3.4	-3.1
Intermittent access day 1 total infusions	5.2	5.9	7.1	-2.3	2.3	2.1	-2.6	2.6	-2.4	2.4	-2.5	2.5	2.1	-2.7	2.5	2.5	-2.4	-2.5	-2.3
Epididymis fat weight	5.0	11.7	30.1	1.3	-1.3	-3.0	1.3	-5.4	2.6	-2.6	5.5	-5.5	-2.7	3.7	-3.5	-3.2	2.7	3.3	2.9
Retroperitoneal fat weight	4.9	16.3	54.3	1.7	-1.7	-3.2	1.7	-6.9	2.6	-2.6	7.4	-7.4	-2.8	4.0	-3.6	-2.9	2.5	3.0	3.0
Time >=10cm from walls, locomotor time 1	4.6	4.7	7.7	1.9	-1.9	-1.9	1.9	-1.7	2.4	-2.4	1.5	-1.5	-2.1	2.2	-2.3	-2.7	2.4	2.8	2.4
Soleus weight	4.5	13.2	17.5	-2.7	2.7	4.0	-2.8	3.8	-3.4	3.4	-3.8	3.8	3.7	-4.0	4.0	4.2	-3.4	-4.2	-3.7
Intermitt. access day 15 inactive lever presses	4.2	4.7	7.4	-1.6	1.6	1.9	-1.7	2.2	-2.3	2.3	-2.2	2.2	2.0	-2.2	2.2	2.7	-2.3	-2.6	-2.2
Extensor digitorum longus weight	4.0	16.0	20.1	-3.0	3.0	4.5	-2.9	4.0	-4.1	4.1	-4.3	4.3	4.3	-4.2	4.2	4.3	-4.1	-4.3	-4.3
Liver weight, right	3.7	6.1	12.9	1.1	-1.1	-2.4	1.2	-3.4	2.3	-2.3	3.6	-3.6	-2.3	2.5	-2.5	-2.4	2.3	2.4	2.4
Ambulatory time before self-admin	3.7	3.9	6.0	-1.5	1.5	2.2	-1.6	0.7	-2.3	2.3	-0.5	0.5	2.4	-2.3	2.5	2.4	-2.3	-2.4	-2.2
Times rat made contact with spout	3.6	4.1	7.7	-0.8	0.8	2.1	-0.5	2.6	-1.8	1.8	-2.8	2.8	1.9	-2.4	2.3	2.1	-1.9	-2.1	-1.9
Delay discounting water rate 12 sec	3.5	5.3	7.7	1.4	-1.4	-2.5	1.1	-2.3	2.4	-2.4	2.3	-2.3	-2.3	2.6	-2.6	-2.8	2.4	2.8	2.5
Delay disc. indifference point, 24s delay	3.5	3.4	6.6	-1.0	1.0	2.2	-1.0	2.4	-1.7	1.7	-2.6	2.6	1.9	-1.9	1.8	1.5	-1.8	-1.6	-1.9
Intermittent access day 1 locomotion	3.4	3.5	5.7	-2.2	2.2	1.5	-2.4	1.6	-1.8	1.8	-1.5	1.5	1.6	-1.9	1.8	2.0	-1.8	-2.0	-1.9
Short access day 1 locomotion	3.4	3.6	5.8	-1.2	1.2	1.8	-1.5	1.5	-2.4	2.4	-1.5	1.5	2.0	-2.1	2.0	2.3	-2.4	-2.3	-1.9
Intraocular pressure	3.3	4.6	6.7	1.9	-1.9	-2.3	2.0	-1.5	2.6	-2.6	1.7	-1.7	-2.4	1.9	-2.0	-2.2	2.4	2.2	2.5
Heart weight	3.2	4.5	8.0	1.3	-1.3	-2.3	1.4	-2.7	2.2	-2.2	2.8	-2.8	-2.1	2.2	-2.1	-1.7	2.2	1.7	2.2
Short access day 1 total inactive lever presses	3.1	3.4	4.9	-2.2	2.2	1.5	-2.1	1.2	-1.8	1.8	-1.3	1.3	1.6	-2.1	2.0	2.2	-1.8	-2.2	-1.8
Tibialis anterior weight	3.0	10.3	14.1	-2.5	2.5	3.5	-2.6	3.5	-3.1	3.1	-3.8	3.8	3.3	-3.3	3.2	3.3	-3.1	-3.3	-3.4
Intermittent access intake escalation	2.8	2.7	4.4	1.0	-1.0	-1.8	1.0	-1.1	2.1	-2.1	1.1	-1.1	-1.8	1.9	-1.8	-1.9	2.1	1.9	1.8
Intermittent access intake escalation 2	2.7	2.6	4.2	0.9	-0.9	-1.9	0.9	-1.2	2.1	-2.1	1.3	-1.3	-1.9	1.8	-1.7	-1.5	2.1	1.6	1.8
Saline control response	2.6	3.5	4.6	-1.8	1.8	1.7	-1.7	1.8	-1.8	1.8	-1.9	1.9	1.6	-2.1	2.1	2.0	-1.7	-2.0	-1.9
Locomotion distance, session 3	2.6	2.8	3.9	-1.0	1.0	1.9	-1.0	2.0	-1.9	1.9	-1.6	1.6	1.8	-1.9	1.8	1.6	-1.8	-1.6	-1.7
Co content in liver	2.6	3.1	5.9	-1.1	1.1	2.0	-0.7	2.3	-1.4	1.4	-2.4	2.4	1.8	-1.9	1.9	1.6	-1.4	-1.7	-1.6
Conditioned reinforcement - inactives	2.5	2.8	4.9	-2.0	2.0	1.2	-2.2	1.5	-1.5	1.5	-1.4	1.4	1.3	-1.8	1.7	1.9	-1.5	-1.9	-1.6
Novelty place preference	2.5	2.6	4.1	2.0	-2.0	-1.2	1.7	-2.0	1.0	-1.0	1.8	-1.8	-1.1	1.8	-1.8	-1.7	1.0	1.7	1.4
Time in novel zone, NPP test	2.5	2.6	4.2	2.1	-2.1	-1.2	1.8	-1.9	1.0	-1.0	1.8	-1.8	-1.1	1.8	-1.8	-1.7	1.1	1.7	1.5
Time >=10cm from walls, locomotor time 2	2.4	2.5	3.7	1.6	-1.6	-1.5	1.7	-1.5	1.4	-1.4	1.5	-1.5	-1.4	1.9	-1.9	-1.7	1.3	1.7	1.6
Social responses	2.3	3.0	5.6	-1.3	1.3	2.0	-1.3	0.3	-2.3	2.3	-0.2	0.2	2.1	-1.7	1.8	2.1	-2.4	-2.0	-2.1
Short access day 10 total infusions	2.3	2.5	3.3	-1.3	1.3	1.2	-1.6	1.7	-1.8	1.8	-1.6	1.6	1.4	-1.8	1.7	1.6	-1.8	-1.7	-1.4
Locomotion velocity, session 7	2.3	2.6	4.6	-2.0	2.0	1.6	-2.2	1.7	-1.3	1.3	-1.7	1.7	1.4	-1.8	1.7	1.0	-1.2	-1.0	-1.5
Bone: cortical porosity	2.3	2.5	5.6	2.1	-2.1	-1.3	2.4	0.7	1.7	-1.7	-0.9	0.9	-1.5	1.2	-1.3	-1.4	1.8	1.3	1.6
Bouts of movement, locomotor time 1	2.3	2.5	3.9	-1.1	1.1	1.8	-1.1	1.7	-1.6	1.6	-2.0	2.0	1.6	-1.9	1.9	1.2	-1.5	-1.2	-1.5
Bone: cortical porosity	2.2	2.4	5.9	2.2	-2.2	-1.2	2.4	0.6	1.7	-1.7	-0.9	0.9	-1.4	1.2	-1.2	-1.3	1.7	1.3	1.5
Delta time in open arm before/after self-admin	2.2	2.1	4.3	-2.1	2.1	1.1	-2.0	1.2	-0.9	0.9	-1.3	1.3	1.1	-1.4	1.5	1.4	-0.8	-1.4	-1.6
Time in open arm after self-admin	2.2	2.5	5.4	-1.4	1.4	1.4	-1.5	2.1	-0.8	0.8	-2.3	2.3	1.1	-1.7	1.8	1.5	-0.8	-1.5	-1.6
Intermittent access intake day 1-15 change	2.1	2.1	3.4	0.9	-0.9	-1.6	0.8	-1.0	1.8	-1.8	1.0	-1.0	-1.6	1.7	-1.7	-1.6	1.8	1.6	1.6
Novel to familiar place preference ratio	2.1	2.2	3.7	1.9	-1.9	-1.0	1.7	-1.9	0.7	-0.7	1.7	-1.7	-0.8	1.6	-1.6	-1.6	0.8	1.6	1.3
Parametrial fat weight	2.0	3.9	6.6	0.4	-0.4	-2.0	0.2	-2.6	2.0	-2.0	2.4	-2.4	-1.8	2.2	-2.1	-2.4	2.1	2.5	1.9
Light reinforcement 2	2.0	2.6	5.4	-1.6	1.6	1.1	-1.7	2.3	-0.9	0.9	-2.3	2.3	0.9	-1.8	1.8	1.6	-0.8	-1.6	-1.3
Progressive ratio test 1 inactive lever presses	2.0	2.2	3.4	-1.5	1.5	1.4	-1.8	0.8	-1.7	1.7	-0.7	0.7	1.6	-1.6	1.6	1.6	-1.7	-1.6	-1.5
Locomotion velocity, NPP test	2.0	2.8	4.0	-1.3	1.3	1.8	-1.3	2.0	-1.8	1.8	-1.7	1.7	1.7	-1.7	1.7	1.7	-1.7	-1.7	-1.7
Locomotion in novel chamber post-restriction	2.0	2.4	3.6	0.9	-0.9	-1.6	0.8	-1.6	1.6	-1.6	1.9	-1.9	-1.6	1.6	-1.6	-1.8	1.6	1.8	1.6
Indifference point AUC	1.9	2.3	3.2	-1.7	1.7	1.3	-1.8	1.7	-1.3	1.3	-1.4	1.4	1.3	-1.7	1.6	1.5	-1.3	-1.6	-1.5
Lifetime Intake	1.8	2.1	4.5	-1.7	1.7	0.9	-2.1	1.6	-1.4	1.4	-1.4	1.4	1.1	-1.5	1.3	1.2	-1.4	-1.2	-1.2
Distance traveled before self-admin	1.8	1.9	3.3	-0.9	0.9	1.6	-1.0	0.2	-1.7	1.7	0.1	-0.1	1.8	-1.6	1.7	1.7	-1.6	-1.7	-1.5
Time to tail flick, vehicle, before self-admin	1.8	1.9	4.0	0.7	-0.7	-1.2	0.7	-1.9	1.1	-1.1	2.0	-2.0	-1.1	1.5	-1.5	-1.4	1.0	1.4	1.4
Delay discounting water rate 6 sec	1.7	2.5	3.1	1.6	-1.6	-1.6	1.3	-1.5	1.7	-1.7	1.5	-1.5	-1.6	1.5	-1.5	-1.6	1.8	1.6	1.6
Intermittent access total infusions	1.6	1.7	4.6	-1.7	1.7	0.8	-2.1	1.5	-1.1	1.1	-1.4	1.4	0.9	-1.3	1.1	1.0	-1.1	-1.0	-1.0
Pavlov. Cond. intertrial magazine entries	1.5	2.0	4.0	1.3	-1.3	-1.6	1.4	-1.6	1.4	-1.4	2.0	-2.0	-1.5	1.2	-1.1	-0.4	1.3	0.4	1.3
Time to tail flick, test, after self-admin	1.5	1.6	2.6	-1.5	1.5	1.1	-1.6	-0.1	-1.4	1.4	0.2	-0.2	1.3	-1.2	1.2	1.5	-1.4	-1.5	-1.2
Delay disc. indifference point, 0s delay	1.5	1.6	2.5	1.1	-1.1	-1.3	1.1	-1.0	1.6	-1.6	1.0	-1.0	-1.3	1.3	-1.2	-1.3	1.6	1.3	1.5
Mg content in liver	1.5	1.6	3.0	-1.1	1.1	1.2	-0.9	1.7	-1.2	1.2	-1.4	1.4	1.0	-1.3	1.3	1.3	-1.1	-1.4	-1.4
Mean time between licks in bursts	1.4	1.9	6.0	0.7	-0.7	-1.1	0.9	-2.4	0.8	-0.8	2.1	-2.1	-0.9	1.5	-1.5	-1.5	0.8	1.5	1.2
Delay discounting total patch changes 18 sec	1.4	1.8	3.1	-1.0	1.0	1.3	-0.9	1.2	-1.2	1.2	-1.2	1.2	1.3	-1.6	1.6	1.8	-1.2	-1.8	-1.5
Change in fecal boli incidents, locomotor task	1.4	1.3	5.2	-0.8	0.8	-0.8	-0.6	-2.1	0.5	-0.5	2.3	-2.3	-0.6	1.0	-0.9	-0.6	0.6	0.6	0.8
Total resting periods, locomotor time 1	1.4	1.6	3.6	-0.6	0.6	1.4	-0.6	1.5	-1.2	1.2	-1.9	1.9	1.2	-1.5	1.4	0.8	-1.1	-0.8	-1.1
Vertical activity count, locomotor time 2	1.4	1.5	1.9	1.3	-1.3	-1.2	1.4	-1.2	1.1	-1.1	1.3	-1.3	-1.1	1.4	-1.3	-1.3	1.1	1.3	1.1
Degree of sensitization distance	1.3	1.4	3.2	0.8	-0.8	-1.1	0.8	-1.8	1.3	-1.3	1.4	-1.4	-1.0	1.1	-1.0	-1.0	1.2	1.0	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	3.0	-1.1	1.1	1.1	-1.1	1.4	-0.8	0.8	-1.7	1.7	1.0	-1.5	1.5	1.5	-0.8	-1.5	-1.1
Extinction: sum of active levers before priming	1.3	1.3	2.8	-0.3	0.3	1.5	-0.3	1.0	-1.3	1.3	-0.9	0.9	1.5	-1.6	1.7	0.9	-1.4	-0.9	-1.2
Delta time to tail flick, test, before/after SA	1.3	1.1	1.6	-1.3	1.3	1.1	-1.3	0.7	-1.1	1.1	-0.3	0.3	1.0	-1.0	1.0	1.2	-1.0	-1.2	-1.2
Water consumed over 24 hours	1.2	1.4	2.5	-0.6	0.6	1.2	-0.4	1.5	-1.0	1.0	-1.6	1.6	1.1	-1.4	1.3	1.2	-1.0	-1.2	-1.2
Delay discounting water rate 24 sec	1.2	1.6	3.8	0.5	-0.5	-1.1	0.5	-1.9	1.0	-1.0	1.9	-1.9	-0.9	1.3	-1.3	-1.2	1.2	1.3	1.2
Conditioned reinforcement - actives	1.2	1.2	2.5	-1.3	1.3	0.8	-1.6	1.1	-1.1	1.1	-0.7	0.7	0.9	-1.2	1.1	1.2	-1.1	-1.2	-1.1
Delta distance traveled before/after self-admin	1.2	1.3	1.8	0.4	-0.4	-1.3	0.5	-1.3	1.2	-1.2	1.3	-1.3	-1.3	1.1	-1.0	-1.2	1.2	1.2	1.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.0	0.3	-0.3	1.0	0.3	1.4	-1.1	1.1	-1.4	1.4	1.0	-1.3	1.3	1.2	-1.1	-1.2	-1.1
Latency to leave start box in cocaine runway, F	1.2	1.3	2.1	-0.8	0.8	1.3	-0.8	1.4	-1.1	1.1	-1.3	1.3	1.2	-1.3	1.3	1.1	-1.0	-1.1	-1.2
Mn content in liver	1.2	1.4	3.3	-0.8	0.8	1.6	-0.3	0.8	-1.8	1.8	-0.7	0.7	1.5	-0.9	0.8	0.9	-1.8	-0.9	-1.5
Na content in liver	1.2	1.3	2.7	-1.1	1.1	1.0	-0.7	1.1	-0.9	0.9	-1.0	1.0	1.0	-1.1	1.2	1.6	-1.0	-1.6	-1.3
Number of licking bursts	1.1	1.3	2.2	-0.7	0.7	1.4	-0.7	0.7	-1.2	1.2	-0.7	0.7	1.4	-1.4	1.5	1.3	-1.4	-1.3	-1.2
Cocaine response before conditioning	1.1	1.4	3.0	-1.6	1.6	1.1	-1.7	0.6	-1.3	1.3	-0.6	0.6	1.2	-1.0	1.0	1.0	-1.2	-1.0	-1.3
One hour access (shock baseline)	1.1	1.3	2.7	-1.3	1.3	0.8	-1.6	1.1	-1.3	1.3	-1.0	1.0	0.9	-1.2	1.0	0.9	-1.3	-0.9	-0.9
Pavlov. Cond. lever latency	1.1	1.4	4.6	0.7	-0.7	-0.8	0.8	-1.7	0.5	-0.5	2.1	-2.1	-0.7	1.2	-1.2	-1.1	0.5	1.1	0.9
Bone: post-yield work	1.1	1.4	2.5	-0.9	0.9	1.4	-0.8	0.9	-1.5	1.5	-0.8	0.8	1.4	-1.2	1.2	1.2	-1.6	-1.1	-1.4
Delay disc. indifference point, 8s delay	1.1	1.1	2.0	-0.7	0.7	1.4	-0.8	1.3	-1.1	1.1	-1.3	1.3	1.3	-1.1	1.0	0.7	-1.1	-0.8	-1.1
Short access day 1 total infusions	1.0	1.0	1.6	-0.8	0.8	0.8	-1.0	0.9	-1.3	1.3	-0.9	0.9	0.9	-1.2	1.1	1.1	-1.3	-1.1	-0.8
Short access total infusions	1.0	1.1	2.0	-1.2	1.2	0.6	-1.4	1.1	-1.2	1.2	-1.0	1.0	0.8	-1.1	1.0	1.0	-1.2	-1.1	-0.8
Time in novel zone, hab. session 1	1.0	0.9	2.1	0.5	-0.5	-0.7	0.7	-1.4	0.7	-0.7	1.3	-1.3	-0.6	1.1	-1.1	-1.2	0.7	1.2	0.8
Total zone transitions, NPP test	1.0	1.4	4.1	-0.9	0.9	1.3	-0.7	2.0	-1.0	1.0	-1.6	1.6	1.0	-1.1	1.1	1.1	-1.0	-1.1	-1.1
Indifference point function ln k	0.9	1.3	2.7	1.6	-1.6	-1.0	1.6	-0.7	0.9	-0.9	0.4	-0.4	-1.1	1.2	-1.3	-1.1	1.0	1.2	1.1
Indifference point function log k	0.9	1.3	2.7	1.6	-1.6	-1.0	1.6	-0.7	0.9	-0.9	0.4	-0.4	-1.1	1.2	-1.3	-1.1	1.0	1.2	1.1
Intermittent access day 15 total locomotion	0.9	0.9	2.9	-1.6	1.6	0.6	-1.7	0.9	-0.8	0.8	-0.6	0.6	0.7	-0.8	0.7	0.7	-0.8	-0.7	-0.9
Progressive ratio test 1 active lever presses	0.9	0.9	3.3	-1.4	1.4	0.5	-1.8	0.1	-1.0	1.0	-0.0	0.0	0.8	-0.9	0.9	0.8	-1.0	-0.9	-0.8
Progressive ratio test 1 breakpoint	0.9	0.9	3.2	-1.3	1.3	0.5	-1.8	0.1	-1.0	1.0	0.0	-0.0	0.8	-0.9	0.9	0.9	-1.0	-1.0	-0.8
Compulsive drug intake	0.9	0.9	1.9	1.1	-1.1	-1.0	1.2	0.1	1.4	-1.4	0.0	-0.0	-1.2	0.4	-0.4	-0.7	1.4	0.6	0.9
Stereotopy head waving bouts, day 3	0.9	1.1	1.7	-0.6	0.6	1.0	-0.5	1.3	-1.0	1.0	-1.3	1.3	1.0	-0.9	0.9	1.3	-1.1	-1.3	-1.1
Total locomotion distance, NPP test	0.9	1.3	2.0	-0.7	0.7	1.4	-0.6	1.3	-1.3	1.3	-1.1	1.1	1.3	-1.1	1.1	1.2	-1.3	-1.2	-1.2
Pavlov. Cond. lever contacts	0.9	1.1	2.6	-0.9	0.9	0.9	-1.0	1.3	-0.7	0.7	-1.6	1.6	0.8	-1.1	1.1	1.0	-0.6	-1.0	-0.9
Pavlov. Cond. response bias	0.9	1.1	2.3	-0.9	0.9	0.7	-0.8	1.2	-0.6	0.6	-1.5	1.5	0.7	-1.2	1.2	1.2	-0.6	-1.2	-0.9
Total heroin consumption	0.9	1.1	2.2	-0.3	0.3	1.0	-0.4	1.3	-1.1	1.1	-1.5	1.5	1.0	-1.1	1.1	1.1	-1.1	-1.1	-1.2
Zn content in liver	0.9	1.0	1.9	-1.4	1.4	0.8	-1.2	0.1	-1.1	1.1	-0.2	0.2	1.0	-1.1	1.1	0.9	-1.1	-1.0	-1.0
Conditioned locomotion	0.8	1.0	2.8	-1.5	1.5	0.7	-1.7	0.4	-1.1	1.1	-0.1	0.1	0.8	-0.6	0.5	0.8	-1.1	-0.8	-1.1
Condit. Reinf. lever presses	0.8	1.1	3.9	-0.7	0.7	0.9	-0.7	1.7	-0.5	0.5	-2.0	2.0	0.6	-1.1	1.0	0.5	-0.5	-0.5	-0.7
Pavlov. Cond. index score	0.8	1.0	1.8	-0.9	0.9	0.8	-1.0	1.0	-0.5	0.5	-1.4	1.4	0.7	-1.2	1.2	1.2	-0.5	-1.2	-0.8
Bone: apparent density	0.8	1.4	7.1	0.5	-0.5	0.4	0.6	2.3	0.1	-0.1	-2.7	2.7	0.0	-0.5	0.4	0.5	0.1	-0.5	-0.4
Bone: maximum diameter	0.8	1.5	2.0	-0.8	0.8	1.3	-0.7	1.1	-1.2	1.2	-1.3	1.3	1.3	-1.2	1.3	1.3	-1.3	-1.3	-1.4
K content in liver	0.8	0.8	1.1	-0.7	0.7	1.1	-0.3	0.8	-1.0	1.0	-0.5	0.5	1.0	-0.8	0.8	1.0	-1.0	-1.0	-1.0
Delay discounting water rate 18 sec	0.7	1.0	2.0	0.4	-0.4	-0.8	0.3	-1.4	0.7	-0.7	1.4	-1.4	-0.7	1.0	-1.0	-1.4	0.7	1.3	0.9
Reaction time mean minus median AUC	0.7	0.9	1.6	0.9	-0.9	-1.1	1.0	0.3	1.2	-1.2	-0.0	0.0	-1.3	1.0	-1.0	-0.8	1.2	0.8	1.0
Reaction time num false alarms AUC	0.7	1.0	2.2	0.4	-0.4	1.2	0.2	1.4	-0.8	0.8	-1.5	1.5	1.0	-1.3	1.3	0.9	-0.7	-0.9	-0.7
Median of all reaction times	0.7	1.0	2.3	1.5	-1.5	-1.2	1.4	-0.2	1.0	-1.0	0.3	-0.3	-1.2	0.7	-0.7	-0.5	1.1	0.6	1.1
Reaction time false alarm rate	0.7	1.0	1.8	0.1	-0.1	1.3	-0.0	0.8	-1.0	1.0	-1.0	1.0	1.2	-1.3	1.3	1.0	-1.0	-1.0	-0.9
Intermittent access terminal intake (last 3 days)	0.7	0.7	2.0	-1.0	1.0	0.2	-1.4	1.3	-0.4	0.4	-1.2	1.2	0.3	-0.8	0.7	0.8	-0.4	-0.7	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.9	-1.2	1.2	0.8	-1.1	0.3	-0.6	0.6	-0.6	0.6	0.8	-1.1	1.2	1.4	-0.7	-1.4	-0.9
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	1.1	-1.1	-0.7	1.4	1.0	0.9	-0.9	-0.8	0.8	-0.9	0.5	-0.7	-0.9	0.8	0.9	0.8
Bone: connectivity density	0.7	1.2	6.0	0.4	-0.4	0.4	0.5	2.1	0.1	-0.1	-2.5	2.5	0.1	-0.6	0.5	0.7	0.1	-0.7	-0.4
Bone: endosteal perimeter	0.7	1.4	2.4	-1.0	1.0	1.3	-0.9	0.8	-1.3	1.3	-0.7	0.7	1.3	-1.3	1.4	1.6	-1.3	-1.5	-1.4
Breakpoint value in progressive ratio session	0.7	0.8	1.8	-0.7	0.7	1.0	-0.8	0.8	-1.3	1.3	-0.8	0.8	1.1	-0.8	0.7	0.4	-1.3	-0.4	-1.0
Delta ambulatory time before/after self-admin	0.7	0.8	1.3	-0.1	0.1	-1.1	0.0	-0.9	1.1	-1.1	0.8	-0.8	-1.1	0.9	-0.9	-1.2	1.1	1.2	0.9
Fecal boli incidents, locomotor time 1	0.7	0.8	3.5	1.9	-1.9	-0.2	1.7	0.3	0.6	-0.6	-0.5	0.5	-0.5	0.5	-0.5	-0.4	0.6	0.4	0.6
Liver weight, left	0.6	1.0	2.4	-0.7	0.7	-0.9	-0.7	-1.5	0.8	-0.8	1.6	-1.6	-0.8	0.8	-0.8	-1.1	0.8	1.1	0.8
Delay discounting water rate 0 sec	0.6	1.0	1.7	1.0	-1.0	-1.0	0.9	-0.4	0.9	-0.9	0.6	-0.6	-1.0	1.0	-1.1	-1.3	1.0	1.3	1.1
Locomotor testing rearing	0.6	1.0	1.3	-0.9	0.9	0.9	-1.1	1.0	-0.8	0.8	-1.1	1.1	0.8	-1.0	1.0	1.1	-0.9	-1.1	-1.0
Reaction time mean	0.6	0.8	1.3	1.2	-1.2	-1.1	1.1	-0.1	1.0	-1.0	0.2	-0.2	-1.1	0.8	-0.8	-0.5	1.1	0.6	0.9
Condit. Reinf. active minus inactive responses	0.6	0.8	1.4	-0.6	0.6	1.0	-0.4	1.2	-0.7	0.7	-1.0	1.0	0.9	-1.0	1.0	1.1	-0.8	-1.1	-0.7
Intermittent access day 15 total infusions	0.6	0.7	1.9	-1.0	1.0	0.3	-1.3	1.4	-0.3	0.3	-1.3	1.3	0.3	-0.8	0.7	0.5	-0.3	-0.6	-0.4
Intermittent access total locomotion	0.6	0.7	3.0	-1.5	1.5	0.3	-1.7	0.6	-0.6	0.6	-0.5	0.5	0.4	-0.5	0.4	0.5	-0.6	-0.5	-0.7
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.7	-1.0	1.0	0.2	-1.3	1.1	-0.4	0.4	-1.1	1.1	0.3	-0.9	0.8	0.8	-0.4	-0.8	-0.6
Short access day 10 total inactive lever presses	0.6	0.6	1.2	-0.3	0.3	0.8	-0.2	0.8	-0.9	0.9	-0.9	0.9	0.8	-0.6	0.6	1.1	-0.9	-1.0	-1.0
Locomotion velocity, hab. session 2	0.6	0.8	1.5	-0.7	0.7	1.0	-0.7	1.0	-1.2	1.2	-0.9	0.9	1.0	-0.7	0.6	0.6	-1.2	-0.6	-0.9
Pavlov. Cond. latency score	0.6	0.8	1.7	-0.8	0.8	0.7	-0.8	0.9	-0.5	0.5	-1.3	1.3	0.6	-1.1	1.1	1.1	-0.4	-1.1	-0.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.6	0.9	-0.9	-0.6	0.8	-0.5	0.6	-0.6	0.7	-0.7	-0.7	1.1	-1.2	-1.3	0.6	1.3	0.7
Bone: trabecular number	0.6	1.0	5.4	0.3	-0.3	0.1	0.4	2.0	0.3	-0.3	-2.3	2.3	-0.2	-0.2	0.0	0.2	0.2	-0.2	-0.2
Ambulatory time after self-admin	0.6	0.7	1.3	-0.9	0.9	0.8	-0.9	-0.5	-0.8	0.8	0.6	-0.6	0.8	-1.0	1.1	0.8	-0.7	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.6	0.6	1.2	0.2	-0.2	-0.8	0.2	-0.3	1.1	-1.1	0.2	-0.2	-0.8	1.0	-1.0	-1.0	1.1	1.0	0.9
Delay discount exponential model param	0.6	0.6	1.8	0.5	-0.5	-0.9	0.5	-1.3	0.6	-0.6	1.3	-1.3	-0.8	0.7	-0.6	-0.3	0.5	0.3	0.7
Rest time, locomotor task time 2	0.6	0.7	1.1	-0.5	0.5	1.0	-0.5	0.8	-1.1	1.1	-0.9	0.9	1.0	-0.9	0.8	0.8	-1.0	-0.8	-0.9
Food seeking constrained by brief footshock	0.6	0.7	3.0	-0.7	0.7	0.3	-0.6	1.4	-0.4	0.4	-1.7	1.7	0.3	-0.7	0.5	0.3	-0.4	-0.2	-0.4
Seeking ratio, punishment vs. effort	0.6	0.7	2.2	0.8	-0.8	-0.2	0.8	1.3	0.7	-0.7	-1.5	1.5	-0.4	-0.1	-0.0	-0.5	0.7	0.6	0.5
Fe content in liver	0.6	0.7	1.5	1.0	-1.0	-1.0	1.2	-0.1	1.0	-1.0	0.2	-0.2	-1.1	0.8	-0.8	-0.4	0.9	0.4	0.8
Reaction time num false alarms	0.5	0.7	1.8	0.8	-0.8	0.9	0.6	1.2	-0.4	0.4	-1.4	1.4	0.6	-0.9	0.8	0.5	-0.3	-0.5	-0.3
Std. dev. reaction times	0.5	0.7	1.3	0.8	-0.8	-1.1	0.8	0.1	1.0	-1.0	0.1	-0.1	-1.1	1.0	-1.1	-0.7	1.0	0.7	0.8
Pavlov. Cond. lever latency	0.5	0.7	1.7	0.4	-0.4	-0.9	0.4	-1.3	0.7	-0.7	1.1	-1.1	-0.7	1.0	-0.9	-0.6	0.7	0.6	0.7
Pavlov. Cond. response bias	0.5	0.7	1.0	-1.0	1.0	1.0	-0.9	1.0	-0.8	0.8	-0.9	0.9	0.9	-0.9	0.8	0.3	-0.8	-0.3	-0.8
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.0	-0.5	0.5	0.9	-0.4	0.2	-0.8	0.8	-0.2	0.2	1.0	-0.6	0.7	1.0	-0.8	-0.9	-1.0
One hour access (0.3 mA shock)	0.5	0.5	2.9	-0.3	0.3	-0.1	-0.6	1.7	-0.1	0.1	-1.4	1.4	-0.1	-0.7	0.6	0.4	-0.1	-0.4	-0.2
Locomotion velocity, session 3	0.5	0.6	2.6	-0.4	0.4	0.7	-0.4	1.6	-0.7	0.7	-1.3	1.3	0.6	-0.7	0.5	0.2	-0.5	-0.2	-0.7
Incentive salience index mean	0.5	0.6	1.0	-0.8	0.8	0.7	-0.9	0.9	-0.5	0.5	-0.9	0.9	0.6	-1.0	0.9	0.6	-0.5	-0.6	-0.6
Time in novel zone, hab. session 2	0.5	0.5	1.4	0.5	-0.5	-0.3	0.4	-1.1	0.4	-0.4	1.2	-1.2	-0.3	0.7	-0.7	-0.9	0.4	0.8	0.5
Total locomotion distance, hab. session 2	0.5	0.7	1.4	-0.6	0.6	1.0	-0.6	0.7	-1.2	1.2	-0.7	0.7	1.0	-0.6	0.5	0.6	-1.2	-0.6	-0.9
Pavlov. Cond. change in total contacts	0.5	0.6	1.3	-0.8	0.8	0.4	-0.8	0.5	-0.3	0.3	-0.7	0.7	0.4	-1.0	1.1	1.1	-0.2	-1.1	-0.5
Bone: marrow area	0.5	1.1	1.7	-0.7	0.7	1.1	-0.6	1.2	-0.9	0.9	-1.1	1.1	1.0	-1.3	1.3	1.1	-1.0	-1.1	-1.1
Bone: periosteal estimation	0.5	1.0	1.5	-0.5	0.5	1.1	-0.4	1.0	-1.0	1.0	-1.1	1.1	1.1	-1.2	1.2	1.1	-1.0	-1.1	-1.1
Bone: periosteal perimeter	0.5	0.8	1.4	-0.6	0.6	1.1	-0.5	0.5	-1.0	1.0	-0.5	0.5	1.1	-0.9	1.0	1.2	-1.0	-1.2	-1.0
Delta time in closed arm before/after self-admin	0.5	0.5	1.9	1.4	-1.4	-0.2	1.4	-0.2	0.2	-0.2	0.3	-0.3	-0.3	0.6	-0.7	-0.4	0.2	0.4	0.5
Time in closed arm after self-admin	0.5	0.5	2.6	0.4	-0.4	-0.3	0.4	-1.3	-0.3	0.3	1.6	-1.6	-0.0	0.3	-0.3	0.0	-0.3	-0.0	0.4
Time to tail flick, test, before self-admin	0.5	0.5	0.9	-0.6	0.6	0.6	-0.7	0.4	-0.7	0.7	-0.7	0.7	0.7	-0.9	0.9	0.8	-0.8	-0.8	-0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	-0.2	0.2	0.8	-0.2	0.8	-0.9	0.9	-1.0	1.0	0.8	-0.5	0.5	0.7	-0.8	-0.7	-0.8
Delay disc. indifference point, 16s delay	0.5	0.5	2.0	-0.1	0.1	0.7	-0.1	1.3	-0.3	0.3	-1.4	1.4	0.4	-0.6	0.5	0.2	-0.3	-0.2	-0.5
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	0.1	-0.1	-0.8	0.2	0.2	0.9	-0.9	-0.3	0.3	-0.8	0.7	-0.8	-1.0	0.9	0.9	0.8
Vertical activity count, locomotor time 1	0.5	0.5	1.1	0.3	-0.3	-0.7	0.3	-0.9	0.8	-0.8	1.0	-1.0	-0.7	0.8	-0.7	-0.6	0.8	0.6	0.6
Locomotion in novel chamber	0.5	0.6	1.3	0.8	-0.8	-0.8	0.6	-1.1	0.5	-0.5	0.9	-0.9	-0.7	0.9	-0.8	-0.5	0.5	0.6	0.6
Rb content in liver	0.5	0.6	2.3	-0.9	0.9	0.6	-0.8	1.5	-0.4	0.4	-1.2	1.2	0.4	-0.7	0.6	0.4	-0.3	-0.5	-0.6
Se content in liver	0.5	0.6	1.4	-0.6	0.6	0.8	-0.5	0.0	-1.2	1.2	-0.1	0.1	1.0	-0.7	0.7	0.8	-1.2	-0.9	-0.9
Body weight	0.4	1.5	3.8	-1.6	1.6	0.8	-1.5	-1.9	-0.9	0.9	1.9	-1.9	1.0	-0.6	0.7	0.6	-0.8	-0.6	-0.8
Tibia length	0.4	1.2	4.8	-1.2	1.2	-0.3	-1.4	-2.0	-0.2	0.2	2.2	-2.2	0.0	0.2	-0.0	0.1	-0.2	-0.1	-0.1
Reaction time mean AUC	0.4	0.5	0.9	1.0	-1.0	-1.0	0.9	0.1	0.8	-0.8	0.1	-0.1	-1.0	0.6	-0.6	-0.4	0.9	0.4	0.8
Reaction time omissions	0.4	0.5	1.4	1.1	-1.1	-0.6	1.2	0.5	0.8	-0.8	-0.3	0.3	-0.8	0.5	-0.6	-0.4	0.9	0.4	0.6
Cocaine response after cond. corrected	0.4	0.4	2.1	0.5	-0.5	-0.1	0.4	1.3	0.3	-0.3	-1.4	1.4	-0.2	0.0	-0.1	-0.3	0.3	0.3	0.2
Cocaine response after cond. not corrected	0.4	0.4	2.3	-0.2	0.2	0.2	-0.3	1.4	-0.0	0.0	-1.5	1.5	0.1	-0.2	0.1	-0.1	-0.0	0.1	-0.2
Condit. Reinf. active responses	0.4	0.5	1.0	-0.6	0.6	0.7	-0.4	0.8	-0.6	0.6	-0.6	0.6	0.6	-0.9	0.8	1.0	-0.6	-1.0	-0.5
Cocaine induced anxiety	0.4	0.4	1.2	0.1	-0.1	0.7	-0.1	0.6	-0.7	0.7	-0.6	0.6	0.6	-0.6	0.6	1.1	-0.7	-0.9	-0.7
Progressive ratio test 2 active lever presses	0.4	0.4	1.9	-1.1	1.1	-0.0	-1.4	0.8	-0.2	0.2	-0.5	0.5	0.1	-0.6	0.6	0.3	-0.2	-0.4	-0.3
Short access day 10 total locomotion	0.4	0.4	1.2	-1.0	1.0	0.4	-1.1	0.2	-0.5	0.5	-0.0	0.0	0.5	-0.4	0.3	0.7	-0.5	-0.6	-0.7
Locomotion distance, session 1	0.4	0.5	3.0	-0.1	0.1	0.0	-0.2	1.7	0.5	-0.5	-1.4	1.4	-0.3	-0.2	0.1	-0.2	0.5	0.2	0.1
Bone surface	0.4	0.7	3.1	0.5	-0.5	0.3	0.6	1.4	-0.1	0.1	-1.8	1.8	0.1	-0.4	0.4	0.7	-0.0	-0.7	-0.4
Bone volume	0.4	0.7	3.7	0.5	-0.5	0.2	0.7	1.6	0.1	-0.1	-1.9	1.9	-0.0	-0.4	0.3	0.6	0.1	-0.5	-0.2
Bone: endosteal estimation	0.4	0.8	1.3	-0.6	0.6	0.9	-0.5	1.1	-0.8	0.8	-1.1	1.1	0.8	-1.1	1.2	0.9	-0.8	-0.9	-1.0
Bone: final force	0.4	0.6	1.3	0.9	-0.9	-0.8	1.1	0.4	0.9	-0.9	-0.6	0.6	-0.9	0.5	-0.6	-0.7	0.8	0.7	0.7
Time in closed arm before self-admin	0.4	0.4	1.9	-0.5	0.5	-0.7	-0.5	-1.4	0.1	-0.1	1.2	-1.2	-0.4	0.4	-0.4	-0.3	0.2	0.3	0.5
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.3	-0.8	0.8	0.2	-1.1	-0.0	-0.6	0.6	0.3	-0.3	0.4	-0.6	0.7	0.9	-0.6	-0.8	-0.6
Run reversals in cocaine runway, males	0.4	0.3	1.3	-0.9	0.9	0.6	-1.1	0.3	-0.5	0.5	-0.2	0.2	0.6	-0.5	0.5	0.4	-0.5	-0.4	-0.6
Latency to leave start box in cocaine runway	0.4	0.4	1.1	0.0	-0.0	0.6	0.0	1.0	-0.6	0.6	-0.8	0.8	0.5	-0.8	0.8	0.6	-0.6	-0.6	-0.7
Cu content in liver	0.4	0.4	1.0	0.1	-0.1	0.6	0.4	0.9	-0.3	0.3	-1.0	1.0	0.5	-0.9	1.0	0.6	-0.4	-0.7	-0.5
Sr content in liver	0.4	0.3	0.8	-0.7	0.7	0.1	-0.9	-0.6	-0.2	0.2	0.7	-0.7	0.2	-0.5	0.6	0.8	-0.2	-0.8	-0.2
BMI without tail	0.3	0.7	2.8	-1.4	1.4	0.4	-1.7	-0.7	-0.6	0.6	0.4	-0.4	0.7	-0.5	0.6	0.5	-0.5	-0.6	-0.5
Tail length	0.3	0.9	1.6	-1.2	1.2	0.7	-1.3	0.6	-0.9	0.9	-0.3	0.3	0.9	-1.0	1.1	0.9	-0.8	-1.1	-0.9
Delay discounting total patch changes 6 sec	0.3	0.4	0.7	-0.3	0.3	0.8	-0.3	0.7	-0.7	0.7	-0.8	0.8	0.7	-0.8	0.8	0.5	-0.8	-0.6	-0.7
Delay discounting time to switch 0 sec	0.3	0.4	0.8	-0.4	0.4	0.9	-0.3	0.4	-0.6	0.6	-0.6	0.6	0.8	-0.6	0.7	0.7	-0.7	-0.7	-0.8
Locomotor activity	0.3	0.5	0.8	0.8	-0.8	-0.6	0.6	0.8	0.9	-0.9	-0.9	0.9	-0.8	0.2	-0.3	-0.2	0.9	0.2	0.6
Locomotor testing distance	0.3	0.4	2.1	0.2	-0.2	0.2	-0.0	1.4	0.2	-0.2	-1.5	1.5	-0.0	-0.4	0.4	0.4	0.2	-0.4	-0.3
Reaction time premature initiation rate	0.3	0.5	1.6	-1.3	1.3	0.7	-1.2	-0.1	-0.4	0.4	0.3	-0.3	0.7	-0.4	0.5	0.1	-0.4	-0.2	-0.6
Conditioned locomotion	0.3	0.3	1.9	-0.0	0.0	0.4	0.1	1.2	0.1	-0.1	-1.4	1.4	0.1	-0.2	0.1	-0.3	-0.0	0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.8	0.8	0.6	-0.5	0.7	-0.4	0.4	-0.6	0.6	0.5	-0.5	0.5	0.3	-0.5	-0.3	-0.4
Condit. Reinf. lever presses	0.3	0.5	0.7	-0.8	0.8	0.6	-0.7	0.6	-0.6	0.6	-0.6	0.6	0.6	-0.8	0.8	0.8	-0.6	-0.8	-0.6
Baseline Anxiety	0.3	0.3	0.6	-0.1	0.1	-0.7	0.2	-0.5	0.8	-0.8	0.5	-0.5	-0.7	0.3	-0.2	-0.7	0.8	0.6	0.7
Progressive ratio test 2 breakpoint	0.3	0.3	1.8	-1.0	1.0	-0.2	-1.3	0.7	0.0	-0.0	-0.4	0.4	-0.1	-0.4	0.4	0.1	0.0	-0.1	-0.1
Condit. Reinf. active responses	0.3	0.3	0.6	-0.6	0.6	0.7	-0.6	0.6	-0.4	0.4	-0.5	0.5	0.5	-0.8	0.8	0.5	-0.4	-0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.6	0.6	0.7	-0.6	0.6	-0.7	0.7	-0.5	0.5	0.6	-0.5	0.5	0.7	-0.7	-0.7	-0.6
Time in familiar zone, hab. session 2	0.3	0.3	0.9	-0.3	0.3	0.1	-0.3	0.8	-0.3	0.3	-0.9	0.9	0.2	-0.5	0.5	1.0	-0.3	-0.9	-0.4
Bone: final moment	0.3	0.5	1.0	0.9	-0.9	-0.7	1.0	0.5	0.8	-0.8	-0.6	0.6	-0.8	0.5	-0.6	-0.7	0.7	0.7	0.6
Bone: minimum diameter	0.3	0.5	0.9	-0.3	0.3	0.8	-0.1	0.5	-0.8	0.8	-0.6	0.6	0.8	-0.9	0.9	1.0	-0.8	-1.0	-0.8
Bone: tissue strength	0.3	0.3	0.8	0.9	-0.9	-0.4	0.9	-0.1	0.4	-0.4	0.3	-0.3	-0.4	0.4	-0.4	-0.5	0.5	0.5	0.5
Time in open arm before self-admin	0.3	0.3	0.8	0.9	-0.9	-0.0	0.8	0.3	0.5	-0.5	-0.4	0.4	-0.3	0.4	-0.4	-0.5	0.3	0.5	0.4
Area under the delay curve	0.3	0.4	1.0	-0.4	0.4	0.8	-0.4	1.0	-0.4	0.4	-1.0	1.0	0.7	-0.5	0.4	0.2	-0.4	-0.2	-0.6
Delay discount hyperbolic model param	0.3	0.4	1.2	0.5	-0.5	-0.7	0.4	-1.1	0.3	-0.3	1.1	-1.1	-0.6	0.4	-0.3	-0.1	0.3	0.1	0.5
Bouts of movement, locomotor time 2	0.3	0.4	0.6	0.7	-0.7	-0.4	0.8	-0.5	0.6	-0.6	0.5	-0.5	-0.4	0.4	-0.3	-0.7	0.6	0.7	0.8
Progressive ratio	0.3	0.4	1.4	-0.8	0.8	-0.2	-0.8	-1.2	-0.3	0.3	1.2	-1.2	-0.0	0.3	-0.3	-0.0	-0.3	-0.0	-0.1
Cd content in liver	0.3	0.3	1.4	1.2	-1.2	-0.2	1.2	-0.3	0.3	-0.3	0.4	-0.4	-0.2	0.4	-0.3	0.1	0.2	-0.1	0.4
BMI with tail	0.2	0.6	3.9	-0.5	0.5	-0.0	-0.5	-2.0	-0.1	0.1	1.6	-1.6	0.1	0.2	-0.1	-0.0	-0.1	0.0	0.0
Indifference point 0 sec	0.2	0.3	0.7	0.6	-0.6	0.4	0.6	0.8	-0.5	0.5	-0.8	0.8	0.3	-0.5	0.5	0.4	-0.5	-0.5	-0.4
Delay discounting total patch changes 0 sec	0.2	0.4	0.7	0.4	-0.4	0.6	0.4	0.7	-0.6	0.6	-0.8	0.8	0.5	-0.7	0.7	0.6	-0.6	-0.7	-0.5
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.3	0.3	0.3	-0.4	0.5	-0.4	0.4	-0.4	0.4	0.3	-0.7	0.6	0.7	-0.2	-0.7	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.6	0.6	0.5	-0.4	0.6	-0.5	0.5	-0.4	0.4	0.5	-0.7	0.7	0.8	-0.5	-0.8	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.7	0.7	0.4	-0.8	0.2	-0.5	0.5	-0.2	0.2	0.4	-0.1	0.1	-0.2	-0.4	0.2	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.4	0.4	0.6	-0.4	0.5	-0.5	0.5	-0.4	0.4	0.5	-0.4	0.4	0.2	-0.6	-0.2	-0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.5	0.5	0.7	-0.4	0.7	-0.5	0.5	-0.5	0.5	0.6	-0.7	0.7	0.3	-0.6	-0.3	-0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	-0.6	-0.6	0.5	-0.0	0.6	-0.6	0.0	-0.0	-0.6	0.2	-0.1	0.3	0.6	-0.3	0.5
Intermitt. access escalation Index	0.2	0.1	0.4	-0.5	0.5	-0.2	-0.6	-0.5	0.4	-0.4	0.5	-0.5	-0.3	0.1	-0.0	-0.1	0.4	0.1	0.2
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.5	0.5	-0.6	-0.7	0.3	0.6	-0.6	-0.0	0.0	-0.6	-0.1	0.1	-0.2	0.6	0.1	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.8	-0.7	0.7	-0.6	-0.9	0.2	0.6	-0.6	0.1	-0.1	-0.6	-0.1	0.1	-0.2	0.6	0.2	0.3
Short access total locomotion	0.2	0.2	1.1	-0.8	0.8	-0.2	-1.0	-0.2	-0.3	0.3	0.3	-0.3	0.1	-0.0	-0.0	0.3	-0.3	-0.3	-0.2
Locomotion velocity, session 1	0.2	0.2	0.6	0.0	-0.0	-0.6	-0.1	0.3	0.7	-0.7	0.1	-0.1	-0.8	0.5	-0.5	-0.5	0.7	0.5	0.4
Stereotopy head waving duration, day 7	0.2	0.3	1.3	0.4	-0.4	0.0	0.3	1.1	0.1	-0.1	-1.1	1.1	-0.1	-0.2	0.2	0.3	0.2	-0.3	-0.1
Locomotion velocity, session 8	0.2	0.2	0.8	-0.5	0.5	0.2	-0.6	0.9	-0.1	0.1	-0.9	0.9	0.2	-0.4	0.4	0.1	-0.2	-0.0	-0.4
Locomotion distance, session 8	0.2	0.3	0.8	-0.0	0.0	0.7	-0.1	0.9	-0.6	0.6	-0.8	0.8	0.6	-0.6	0.5	0.4	-0.6	-0.4	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.7	0.7	0.2	-0.7	0.5	-0.3	0.3	-0.3	0.3	0.2	-0.6	0.6	0.5	-0.3	-0.5	-0.4
Total zone transitions, hab. session 2	0.2	0.2	1.2	0.3	-0.3	0.2	0.3	1.1	-0.3	0.3	-0.8	0.8	0.1	0.1	-0.2	-0.3	-0.2	0.3	0.0
Bone: cortical area	0.2	0.3	0.5	-0.3	0.3	0.7	-0.0	0.3	-0.7	0.7	-0.5	0.5	0.7	-0.5	0.5	0.6	-0.7	-0.6	-0.6
Bone: trabecular spacing	0.2	0.3	0.8	-0.3	0.3	0.2	-0.2	-0.9	-0.6	0.6	0.9	-0.9	0.5	-0.4	0.4	0.4	-0.5	-0.4	-0.2
Distance traveled after self-admin	0.2	0.2	0.7	-0.2	0.2	0.3	-0.3	-0.6	-0.2	0.2	0.8	-0.8	0.3	-0.7	0.8	0.3	-0.1	-0.3	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.6	-0.8	0.8	-0.0	-0.7	-0.5	-0.5	0.5	0.5	-0.5	0.2	0.0	-0.0	-0.1	-0.5	0.1	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.8	0.1	-0.1	-0.0	-0.0	-0.9	-0.4	0.4	0.8	-0.8	0.2	0.4	-0.5	-0.2	-0.4	0.2	0.0
Rest time, locomotor task time 1	0.2	0.2	0.5	0.6	-0.6	-0.1	0.7	0.1	0.2	-0.2	-0.3	0.3	-0.1	0.2	-0.2	-0.6	0.2	0.7	0.4
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.1	-0.1	-0.7	0.0	-0.6	0.5	-0.5	0.6	-0.6	-0.7	0.5	-0.5	-0.4	0.6	0.4	0.4
Weight adjusted by age	0.2	0.2	0.9	-0.7	0.7	-0.1	-1.0	-0.3	0.2	-0.2	0.4	-0.4	-0.0	0.2	-0.1	-0.6	0.2	0.8	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	0.8	-0.8	-0.4	0.9	-0.2	0.3	-0.3	0.3	-0.3	-0.4	0.2	-0.2	-0.4	0.3	0.4	0.4
Glucose	0.1	0.2	0.9	-0.2	0.2	-0.0	-0.4	-0.6	-0.3	0.3	1.0	-1.0	0.2	-0.1	0.1	0.4	-0.3	-0.4	-0.2
Left kidney weight	0.1	0.2	1.0	-0.8	0.8	-0.0	-1.0	0.1	0.3	-0.3	-0.1	0.1	-0.1	-0.1	0.2	0.0	0.2	0.0	-0.2
Right kidney weight	0.1	0.2	0.8	-0.6	0.6	-0.1	-0.5	-0.7	0.3	-0.3	0.9	-0.9	-0.1	0.2	-0.2	-0.1	0.2	0.2	0.0
Length with tail	0.1	0.4	0.9	-0.6	0.6	0.5	-0.4	-0.5	-0.5	0.5	1.0	-1.0	0.6	-0.5	0.6	0.4	-0.4	-0.5	-0.5
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.2	-0.2	0.3	0.4	0.1	-0.2	0.2	0.1	-0.1	0.2	-0.4	0.5	0.5	-0.2	-0.5	-0.2
Mean num. licks in bursts	0.1	0.1	0.7	0.2	-0.2	-0.2	0.4	0.6	0.1	-0.1	-0.8	0.8	-0.2	0.1	-0.2	-0.0	0.2	0.0	0.0
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.4	-0.4	0.1	0.5	-0.6	0.1	-0.1	0.5	-0.5	0.0	0.3	-0.2	-0.3	-0.0	0.3	0.2
Reaction time number correct	0.1	0.1	0.4	0.1	-0.1	-0.2	0.1	0.6	0.3	-0.3	-0.4	0.4	-0.3	0.1	-0.2	-0.2	0.4	0.2	0.3
Reaction time mean minus median	0.1	0.2	0.5	0.1	-0.1	-0.5	0.1	0.7	0.5	-0.5	-0.5	0.5	-0.6	0.5	-0.5	-0.2	0.5	0.2	0.2
Reaction time trials correct on left	0.1	0.1	0.4	0.1	-0.1	-0.2	0.1	0.6	0.3	-0.3	-0.4	0.4	-0.3	0.1	-0.2	-0.2	0.4	0.2	0.3
Reaction time trials on left	0.1	0.1	0.4	0.2	-0.2	-0.2	0.2	0.7	0.3	-0.3	-0.5	0.5	-0.3	0.1	-0.2	-0.2	0.4	0.2	0.3
Reaction time premature initiations	0.1	0.2	0.7	-0.8	0.8	0.4	-0.7	0.1	-0.1	0.1	0.2	-0.2	0.4	-0.2	0.3	-0.1	-0.1	0.1	-0.3
Reaction time trials completed	0.1	0.1	0.4	0.2	-0.2	-0.2	0.2	0.7	0.3	-0.3	-0.5	0.5	-0.3	0.1	-0.2	-0.2	0.4	0.2	0.3
Reaction time trials AUC	0.1	0.1	0.5	0.1	-0.1	-0.3	0.1	0.7	0.3	-0.3	-0.5	0.5	-0.3	0.1	-0.2	-0.2	0.4	0.2	0.3
Social response proportion	0.1	0.1	0.2	-0.4	0.4	0.0	-0.4	-0.1	-0.1	0.1	0.2	-0.2	0.0	0.3	-0.4	-0.5	-0.2	0.5	-0.1
Social time	0.1	0.1	0.5	-0.3	0.3	-0.5	-0.2	-0.1	0.2	-0.2	0.2	-0.2	-0.3	0.6	-0.6	-0.7	0.0	0.7	0.2
Pavlov. Cond. index score	0.1	0.2	0.3	-0.5	0.5	0.6	-0.4	0.5	-0.5	0.5	-0.4	0.4	0.5	-0.4	0.3	0.1	-0.5	-0.1	-0.4
Intermittent access standard deviation	0.1	0.1	0.3	-0.5	0.5	-0.2	-0.5	-0.2	0.1	-0.1	0.5	-0.5	-0.1	0.2	-0.2	-0.0	0.1	0.2	0.1
Post-drug Anxiety	0.1	0.2	0.4	0.5	-0.5	-0.4	0.4	0.3	0.6	-0.6	-0.2	0.2	-0.6	0.2	-0.1	0.1	0.6	0.0	0.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.2	-0.2	-0.0	-0.0	-0.1	-0.5	0.5	0.1	-0.1	0.2	-0.1	0.0	0.1	-0.5	-0.1	0.0
Number of responses in last shaping day	0.1	0.1	0.2	0.2	-0.2	0.1	-0.0	-0.4	-0.3	0.3	0.4	-0.4	0.2	-0.2	0.1	0.2	-0.3	-0.2	0.2
Context. condit. distance diff. score	0.1	0.1	0.2	0.2	-0.2	0.2	0.2	-0.4	-0.4	0.4	0.4	-0.4	0.3	-0.1	0.1	0.3	-0.3	-0.3	-0.2
Locomotion velocity, session 2	0.1	0.2	0.7	0.3	-0.3	-0.2	0.4	0.8	0.5	-0.5	-0.4	0.4	-0.4	0.1	-0.1	-0.4	0.5	0.4	0.3
Locomotion distance, session 2	0.1	0.2	0.6	0.2	-0.2	-0.2	0.2	0.8	0.5	-0.5	-0.7	0.7	-0.4	0.1	-0.2	-0.4	0.4	0.4	0.3
Locomotion distance, session 7	0.1	0.1	0.4	-0.2	0.2	0.4	-0.1	0.0	-0.2	0.2	-0.2	0.2	0.4	-0.6	0.6	0.3	-0.2	-0.3	-0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.7	-0.7	-0.1	0.5	0.2	0.1	-0.1	-0.2	0.2	-0.2	0.2	-0.2	0.1	0.2	-0.2	0.1
Degree of sensitization stereotypy	0.1	0.1	0.4	0.7	-0.7	0.1	0.5	0.0	0.1	-0.1	-0.1	0.1	-0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.6	0.6	0.1	-0.6	-0.2	-0.1	0.1	0.4	-0.4	0.1	-0.3	0.3	0.2	-0.1	-0.2	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	-0.3	0.0	0.2	0.3	0.3	-0.3	-0.4	0.4	-0.1	0.1	-0.1	-0.4	0.3	0.4	0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.6	0.2	-0.2	-0.0	0.1	0.0	-0.0	0.0	-0.1	0.1	-0.0	-0.3	0.3	0.8	-0.0	-0.8	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.6	-0.6	-0.2	0.7	0.3	0.2	-0.2	-0.0	0.0	-0.3	0.5	-0.6	-0.5	0.2	0.5	0.4
Bone: cortical apparent density	0.1	0.1	0.6	-0.6	0.6	-0.1	-0.8	0.1	-0.0	0.0	-0.1	0.1	-0.1	0.1	-0.2	-0.2	-0.1	0.2	-0.1
Bone: cortical thickness	0.1	0.2	0.5	0.5	-0.5	-0.3	0.7	-0.6	0.1	-0.1	0.6	-0.6	-0.2	0.5	-0.4	-0.3	0.2	0.3	0.4
Bone: cortical thickness	0.1	0.2	0.4	0.5	-0.5	-0.2	0.7	0.2	0.3	-0.3	-0.4	0.4	-0.3	0.3	-0.4	-0.5	0.3	0.5	0.5
Bone: cortical tissue density	0.1	0.1	0.5	-0.6	0.6	-0.2	-0.7	-0.0	0.1	-0.1	0.0	-0.0	-0.2	0.2	-0.3	-0.3	0.0	0.3	0.0
Bone: elastic displacement	0.1	0.1	0.3	-0.1	0.1	-0.3	-0.1	0.0	0.2	-0.2	-0.0	0.0	-0.3	0.4	-0.5	-0.5	0.4	0.6	0.4
Bone: elastic work	0.1	0.1	0.3	0.2	-0.2	0.2	0.4	0.6	-0.2	0.2	-0.5	0.5	0.1	0.0	-0.1	-0.3	-0.0	0.2	0.0
Bone: trabecular thickness	0.1	0.2	0.6	0.4	-0.4	0.0	0.6	0.8	0.2	-0.2	-0.8	0.8	-0.2	-0.1	0.1	0.1	0.3	-0.2	0.0
Bone: trabecular tissue density	0.1	0.1	0.2	-0.3	0.3	0.3	-0.2	0.1	-0.4	0.4	0.0	-0.0	0.2	-0.2	0.2	0.5	-0.4	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.3	0.3	-0.0	-0.4	0.6	-0.2	0.2	-0.6	0.6	0.1	0.0	-0.1	0.1	-0.2	-0.1	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.4	-0.0	0.4	-0.3	0.2	-0.2	0.3	-0.3	-0.0	0.0	0.1	-0.4	0.2	0.3	0.4
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.0	0.0	-0.6	-0.0	-0.4	0.3	-0.3	0.6	-0.6	-0.4	0.4	-0.4	-0.2	0.3	0.3	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.1	0.1	0.3	-0.2	-0.3	-0.4	0.4	0.2	-0.2	0.4	-0.0	0.0	0.1	-0.5	-0.2	-0.3
Length without tail	0.0	0.1	0.4	0.2	-0.2	0.3	0.6	-0.3	-0.2	0.2	0.6	-0.6	0.2	-0.1	0.1	0.1	-0.2	-0.0	-0.2
Delay discounting total patch changes 12 sec	0.0	0.1	0.3	-0.1	0.1	-0.2	-0.3	0.1	0.5	-0.5	0.1	-0.1	-0.4	-0.1	0.1	-0.2	0.4	0.1	0.2
Delay discounting total patch changes 24 sec	0.0	0.0	0.2	0.2	-0.2	0.0	0.2	-0.2	-0.0	0.0	0.4	-0.4	0.0	0.1	-0.1	-0.2	-0.1	0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	0.2	-0.2	0.5	0.1	0.4	-0.2	0.2	-0.3	0.3	0.3	-0.2	0.2	-0.1	-0.3	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.1	0.2	-0.1	0.2	-0.2	0.2	-0.1	0.1	0.2	-0.1	0.0	-0.2	-0.2	0.2	-0.1
Stereotopy head waving duration, day 3	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.3	0.4	0.2	-0.2	-0.3	0.3	-0.2	0.1	-0.1	0.1	0.2	-0.1	0.0
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.0	0.2	-0.1	-0.0	0.0	0.1	-0.1	-0.0	0.3	-0.3	0.0	-0.0	0.0	0.0
Bone: maximum force	0.0	0.0	0.4	0.3	-0.3	0.0	0.7	0.0	-0.0	0.0	-0.1	0.1	-0.0	0.0	-0.0	-0.0	-0.1	-0.0	0.0
Bone: maximum moment	0.0	0.0	0.3	0.2	-0.2	0.1	0.5	0.1	-0.1	0.1	-0.2	0.2	0.1	-0.0	0.0	0.0	-0.2	-0.1	-0.1
Bone: stiffness	0.0	0.0	0.3	0.3	-0.3	0.1	0.6	-0.1	0.0	-0.0	0.0	-0.0	0.0	-0.2	0.3	0.1	-0.1	-0.1	0.0

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.