Hub : Genes

Dnmt3a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000026649 0.27 0.13 0.0e+00 0.16 0.14 0.16 0.16 2.0e-17 7.6e-16 7.0e-18 4.7e-17
2 Brain gene expression ENSRNOG00000026649 0.06 0.05 2.9e-05 0.05 0.04 0.04 0.04 1.9e-05 9.3e-05 2.4e-04 9.1e-05
3 Brain mRNA stability ENSRNOG00000026649 0.04 0.03 2.2e-04 0.04 0.03 0.04 0.04 1.7e-04 7.4e-04 2.0e-04 3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.58.39.52.53.03.1
BMI without tail0.51.11.80.61.41.1
Body weight1.66.68.12.12.72.8
Epididymis fat weight17.240.147.95.56.56.9
Glucose0.30.50.80.40.70.9
Heart weight5.27.48.32.72.62.9
Left kidney weight0.51.42.2-1.5-1.3-0.7
Right kidney weight0.10.30.7-0.00.40.8
Tail length0.30.91.2-1.0-0.7-1.1
Length with tail0.00.10.1-0.3-0.0-0.2
Length without tail0.00.10.1-0.3-0.3-0.1
Liver weight, left0.91.52.40.71.51.2
Liver weight, right4.98.19.42.63.12.9
Parametrial fat weight11.322.125.34.05.05.0
Retroperitoneal fat weight32.3106.7123.19.510.311.1
Intraocular pressure2.94.14.81.92.02.2
Extensor digitorum longus weight2.39.310.0-3.0-3.0-3.2
Soleus weight2.77.99.5-2.5-2.8-3.1
Tibialis anterior weight1.13.84.7-1.8-1.8-2.2
Tibia length0.51.52.31.01.51.2
Number of licking bursts1.11.41.71.01.21.3
Food consumed during 24 hour testing period0.10.10.10.40.4-0.1
Times rat made contact with spout1.11.21.8-1.1-0.9-1.3
Mean time between licks in bursts1.92.72.91.51.71.7
Mean num. licks in bursts1.72.12.9-1.2-1.3-1.7
Std. dev. time between licks in bursts0.70.81.11.10.70.9
Water consumed over 24 hours0.10.20.3-0.1-0.4-0.5
Indifference point 0 sec0.40.70.91.00.90.6
Indifference point AUC0.00.00.10.20.20.1
Indifference point function ln k1.92.63.1-1.6-1.8-1.5
Indifference point function log k1.92.63.1-1.6-1.8-1.5
Delay discounting total patch changes 0 sec0.40.61.01.00.80.5
Delay discounting total patch changes 12 sec1.31.72.01.21.41.3
Delay discounting total patch changes 18 sec0.50.70.80.90.80.7
Delay discounting total patch changes 24 sec1.21.51.91.31.41.0
Delay discounting total patch changes 6 sec1.92.93.31.81.81.5
Delay discounting time to switch 0 sec0.50.81.20.80.71.1
Delay discounting water rate 0 sec2.03.14.1-1.4-1.8-2.0
Delay discounting water rate 12 sec0.00.10.20.40.20.2
Delay discounting water rate 18 sec1.72.23.4-1.1-1.4-1.8
Delay discounting water rate 24 sec0.10.10.20.50.10.1
Delay discounting water rate 6 sec0.50.71.2-0.4-0.8-1.1
Locomotor activity0.50.81.30.51.01.1
Locomotor testing distance0.40.71.30.50.81.2
Locomotor testing rearing0.50.71.0-1.0-0.9-0.6
Light reinforcement 10.40.70.9-0.8-1.0-0.8
Light reinforcement 21.21.62.3-1.0-1.5-1.3
Reaction time number correct0.60.81.1-1.0-0.9-0.8
Reaction time mean minus median0.30.30.6-0.70.30.6
Reaction time mean minus median AUC0.30.30.4-0.50.60.7
Reaction time num false alarms1.31.82.11.21.51.3
Reaction time num false alarms AUC1.21.62.11.11.41.3
Reaction time trials correct on left0.60.81.1-1.0-0.9-0.8
Reaction time trials on left0.60.81.1-1.1-0.9-0.8
Reaction time mean0.10.20.30.00.40.6
Reaction time mean AUC0.10.10.1-0.20.20.4
Median of all reaction times0.00.10.10.20.30.3
Reaction time omissions0.10.20.3-0.20.40.6
Reaction time false alarm rate2.23.13.61.81.91.7
Reaction time premature initiation rate0.00.00.10.30.10.0
Reaction time premature initiations0.10.10.2-0.2-0.4-0.3
Std. dev. reaction times0.30.40.7-0.20.70.8
Reaction time trials completed0.60.81.1-1.1-0.9-0.8
Reaction time trials AUC0.60.91.3-1.1-0.9-0.7
Social response proportion0.10.20.4-0.3-0.60.0
Social responses0.10.10.30.20.20.6
Social time0.10.10.3-0.4-0.5-0.1
Conditioned locomotion3.03.64.6-1.8-2.2-1.7
Cocaine response after cond. corrected0.10.20.2-0.5-0.4-0.3
Cocaine response after cond. not corrected0.91.01.4-1.2-0.8-0.9
Cocaine response before conditioning2.53.13.7-1.9-1.7-1.6
Saline control response1.82.43.0-1.6-1.7-1.3
Condit. Reinf. active minus inactive responses1.62.02.2-1.4-1.5-1.3
Condit. Reinf. active-inactive response ratio0.91.01.2-1.1-1.0-0.9
Condit. Reinf. active responses1.11.61.8-1.3-1.3-1.1
Condit. Reinf. inactive responses0.30.40.5-0.7-0.6-0.5
Condit. Reinf. lever presses1.01.31.4-1.1-1.2-1.2
Condit. Reinf. lever reinforcers received1.11.51.7-1.3-1.3-1.1
Pavlov. Cond. lever latency0.50.71.10.61.00.8
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.10.1
Pavlov. Cond. change in total contacts0.00.00.00.1-0.2-0.1
Pavlov. Cond. index score0.20.30.5-0.3-0.7-0.6
Pavlov. Cond. latency score0.20.30.5-0.3-0.7-0.6
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.4-0.2
Pavlov. Cond. magazine entry number0.10.10.2-0.5-0.2-0.4
Pavlov. Cond. intertrial magazine entries1.62.13.31.21.81.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.0-0.4-0.3
Pavlov. Cond. response bias0.20.20.4-0.4-0.6-0.4
Conditioned reinforcement - actives3.63.54.4-1.7-1.9-2.1
Conditioned reinforcement - inactives5.86.57.1-2.4-2.7-2.6
Conditioned locomotion4.85.86.8-2.2-2.4-2.6
Intermittent access intake day 1-15 change2.12.13.4-1.1-1.4-1.8
Intermittent access intake escalation1.41.32.4-0.8-1.0-1.6
Intermittent access intake escalation 20.10.10.20.40.1-0.4
Intermitt. access day 1 inactive lever presses0.20.20.3-0.4-0.5-0.3
Intermitt. access day 15 inactive lever presses1.21.41.9-1.4-1.2-1.0
Intermitt. access escalation Index4.03.64.12.01.62.0
Intermittent access day 1 total infusions1.71.92.5-1.4-1.6-1.2
Intermittent access day 15 total infusions3.23.53.9-1.7-1.9-2.0
Intermittent access terminal intake (last 3 days)2.62.93.1-1.6-1.7-1.8
Intermittent access total infusions3.64.04.6-2.0-2.1-1.9
Intermittent access day 1 locomotion1.91.92.4-1.2-1.5-1.4
Intermittent access day 15 total locomotion0.20.20.4-0.3-0.5-0.6
Intermittent access total locomotion0.91.01.3-0.8-1.1-1.1
Intermittent access standard deviation0.50.50.8-0.5-0.7-0.9
Cocaine induced anxiety0.00.00.1-0.0-0.1-0.3
Post-drug Anxiety1.31.42.01.11.40.9
Baseline Anxiety1.41.51.91.11.41.1
Lifetime Intake4.04.54.9-2.1-2.2-2.0
Incentive Sensitization - Responses1.51.51.8-1.0-1.3-1.3
Incentive Sensitization - Breakpoint0.90.91.1-0.7-1.0-1.1
Progressive ratio test 1 active lever presses2.22.22.7-1.6-1.4-1.5
Progressive ratio test 1 breakpoint1.51.61.9-1.4-1.2-1.2
Progressive ratio test 1 inactive lever presses3.84.14.5-2.0-2.1-1.9
Progressive ratio test 2 active lever presses2.12.22.5-1.4-1.5-1.6
Progressive ratio test 2 breakpoint2.12.32.6-1.4-1.6-1.6
Progressive ratio test 2 inactive lever presses2.42.83.4-1.5-1.7-1.8
Total sessions with >9 infusions6.77.47.8-2.8-2.7-2.6
Short access day 1 total inactive lever presses1.51.61.7-1.3-1.3-1.2
Short access day 10 total inactive lever presses0.20.20.50.10.20.7
Short access day 1 total infusions2.93.13.6-1.7-1.9-1.7
Short access day 10 total infusions4.34.75.3-2.2-2.3-2.0
Short access total infusions3.23.53.9-2.0-1.8-1.8
Short access day 1 locomotion5.45.76.6-2.6-2.3-2.3
Short access day 10 total locomotion1.71.82.0-1.2-1.4-1.4
Short access total locomotion2.22.32.6-1.4-1.5-1.6
Compulsive drug intake5.35.36.62.62.12.1
One hour access (0.3 mA shock)2.32.73.7-1.3-1.7-1.9
One hour access (shock baseline)7.38.48.8-2.8-2.9-3.0
Number of responses in last shaping day2.12.23.0-1.4-1.7-1.2
Context. condit. distance diff. score0.00.00.0-0.2-0.1-0.1
Locomotion velocity, session 10.30.30.40.50.70.6
Locomotion distance, session 10.91.21.4-1.0-1.0-1.2
Locomotion velocity, session 20.20.20.30.50.30.5
Locomotion distance, session 20.10.10.2-0.1-0.2-0.5
Locomotion velocity, session 30.00.00.00.20.10.2
Locomotion distance, session 30.00.00.10.30.20.1
Stereotopy head waving bouts, day 31.82.22.2-1.5-1.5-1.5
Stereotopy head waving duration, day 30.20.20.3-0.4-0.5-0.3
Locomotion velocity, session 70.10.10.20.50.30.1
Locomotion distance, session 71.41.82.41.51.31.1
Stereotopy head waving bouts, day 70.00.00.1-0.3-0.00.2
Stereotopy head waving duration, day 70.30.40.7-0.8-0.6-0.4
Locomotion velocity, session 80.50.60.7-0.8-0.6-0.8
Locomotion distance, session 80.20.30.6-0.2-0.5-0.8
Degree of sensitization distance1.21.21.31.11.11.1
Degree of sensitization stereotypy0.30.40.80.30.50.9
Condit. Reinf. active minus inactive responses2.12.32.91.31.71.5
Condit. Reinf. active-inactive response ratio2.32.53.11.41.81.6
Condit. Reinf. active responses0.10.10.20.20.40.3
Condit. Reinf. inactive responses1.92.32.4-1.5-1.5-1.5
Incentive salience index mean0.20.20.40.20.60.5
Condit. Reinf. lever presses0.91.21.4-1.2-1.0-1.1
Time in familiar zone, hab. session 11.21.21.21.01.11.1
Time in novel zone, hab. session 10.10.10.20.30.30.5
Total zone transitions, hab. session 10.30.50.8-0.6-0.5-0.9
Total locomotion distance, hab. session 11.21.72.1-1.3-1.1-1.5
Locomotion velocity, hab. session 11.92.73.3-1.6-1.5-1.8
Time in familiar zone, hab. session 20.70.71.01.00.80.7
Time in novel zone, hab. session 20.10.10.1-0.3-0.20.2
Total zone transitions, hab. session 20.00.00.10.00.2-0.3
Total locomotion distance, hab. session 20.00.00.1-0.00.1-0.3
Locomotion velocity, hab. session 20.10.10.2-0.3-0.0-0.4
Novel to familiar place preference ratio0.10.10.40.60.2-0.2
Novelty place preference0.20.20.60.80.30.1
Time in novel zone, NPP test0.20.20.60.80.30.1
Total zone transitions, NPP test1.01.51.6-1.3-1.1-1.2
Total locomotion distance, NPP test1.92.62.9-1.6-1.5-1.7
Locomotion velocity, NPP test2.53.63.8-2.0-1.8-1.9
Pavlov. Cond. lever latency0.50.60.80.90.80.6
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.00.1
Pavlov. Cond. change in total contacts0.00.00.00.1-0.10.0
Pavlov. Cond. index score0.10.10.1-0.3-0.4-0.1
Pavlov. Cond. latency score0.00.10.1-0.3-0.3-0.1
Pavlov. Cond. lever contacts0.40.50.7-0.8-0.7-0.5
Pavlov. Cond. magazine entry number0.10.10.10.30.30.3
Pavlov. Cond. intertrial magazine entries1.51.82.1-1.5-1.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.7-0.8-0.5
Pavlov. Cond. response bias0.91.11.3-1.0-1.1-0.9
Bone: apparent density3.55.86.1-2.5-2.5-2.3
Bone surface0.71.31.6-1.1-1.3-1.1
Bone volume2.03.33.9-1.7-2.0-1.8
Bone: connectivity density2.13.34.0-2.0-1.9-1.6
Bone: cortical apparent density0.00.10.1-0.4-0.2-0.1
Bone: cortical area0.00.00.10.30.20.1
Bone: cortical porosity4.04.34.5-2.1-2.1-2.0
Bone: cortical porosity3.33.53.8-1.9-1.9-1.8
Bone: cortical thickness0.20.40.50.70.70.4
Bone: cortical thickness0.80.91.5-0.7-0.9-1.2
Bone: cortical tissue density0.00.10.1-0.3-0.2-0.1
Bone: elastic displacement1.92.12.4-1.6-1.3-1.5
Bone: elastic work0.50.60.8-0.8-0.6-0.9
Bone: endosteal estimation0.10.20.3-0.2-0.5-0.5
Bone: endosteal perimeter0.00.00.0-0.1-0.20.0
Bone: final force0.00.10.20.00.20.4
Bone: final moment0.00.10.10.10.20.4
Bone: marrow area0.10.20.3-0.2-0.5-0.6
Bone: maximum diameter0.00.00.00.0-0.2-0.2
Bone: maximum force0.00.10.10.20.30.3
Bone: maximum moment0.00.00.00.20.20.2
Bone: minimum diameter0.71.31.41.11.01.2
Bone: periosteal estimation0.10.20.3-0.2-0.4-0.6
Bone: periosteal perimeter0.00.00.00.20.00.2
Bone: post-yield work1.31.82.3-1.1-1.3-1.5
Bone: stiffness0.30.40.60.70.50.7
Bone: tissue strength0.80.81.30.70.81.1
Bone: trabecular number3.55.45.8-2.4-2.3-2.3
Bone: trabecular spacing1.11.41.71.31.31.0
Bone: trabecular thickness0.70.81.1-1.0-0.9-0.7
Bone: trabecular tissue density0.10.10.2-0.4-0.1-0.4
Breakpoint value in progressive ratio session1.21.31.6-1.0-1.3-1.2
Distance traveled before self-admin0.10.10.2-0.1-0.4-0.2
Distance traveled after self-admin0.30.30.40.60.70.2
Delta time in closed arm before/after self-admin0.60.60.70.90.60.8
Delta time in open arm before/after self-admin0.20.20.4-0.7-0.3-0.3
Diff in mean of infusions in LGA sessions0.10.10.2-0.50.10.2
Extinction: sum of active levers before priming0.30.30.5-0.5-0.7-0.3
Active lever presses in extinction session 62.72.64.0-2.0-1.5-1.2
Delta distance traveled before/after self-admin2.12.23.51.21.91.3
Delta ambulatory time before/after self-admin0.50.51.00.61.00.5
Time in closed arm before self-admin0.10.10.3-0.3-0.1-0.6
Time in closed arm after self-admin0.10.10.30.00.60.3
Time in open arm before self-admin0.30.30.40.60.40.6
Time in open arm after self-admin0.00.00.1-0.1-0.2-0.2
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.10.0
Time to tail flick, vehicle, before self-admin0.10.10.2-0.20.30.5
Time to tail flick, vehicle, after self-admin5.55.96.72.22.52.6
Time to tail flick, test, before self-admin2.62.52.5-1.6-1.6-1.6
Time to tail flick, test, after self-admin1.21.21.3-1.2-1.1-1.0
Delta time to tail flick, vehicle, before/after SA3.23.13.61.91.81.6
Delta time to tail flick, test, before/after SA0.60.61.1-0.5-1.0-0.6
Ambulatory time before self-admin0.10.10.3-0.1-0.5-0.2
Ambulatory time after self-admin0.10.10.20.40.50.0
Total heroin consumption1.41.72.5-0.7-1.6-1.5
Area under the delay curve0.10.20.20.5-0.20.5
Delay disc. indifference point, 0s delay1.21.32.01.40.51.3
Delay disc. indifference point, 16s delay0.00.00.00.2-0.00.1
Delay disc. indifference point, 2s delay0.30.30.50.70.30.6
Delay disc. indifference point, 24s delay3.93.83.8-1.9-1.9-2.0
Delay disc. indifference point, 4s delay0.40.40.80.90.10.7
Delay disc. indifference point, 8s delay0.10.10.20.4-0.50.2
Delay discount exponential model param0.10.10.1-0.20.3-0.2
Delay discount hyperbolic model param0.10.10.2-0.40.2-0.3
Fecal boli incidents, locomotor time 13.03.23.9-1.5-1.9-2.0
Change in fecal boli incidents, locomotor task4.03.84.42.11.81.9
Time >=10cm from walls, locomotor time 10.80.80.8-0.9-0.8-0.9
Bouts of movement, locomotor time 10.20.20.30.5-0.4-0.3
Total resting periods, locomotor time 10.20.20.30.5-0.5-0.4
Rest time, locomotor task time 10.20.20.50.7-0.3-0.1
Distance moved, locomotor task time 10.40.40.7-0.60.90.4
Vertical activity count, locomotor time 10.10.10.3-0.40.50.2
Time >=10cm from walls, locomotor time 21.31.31.6-1.3-1.0-1.1
Bouts of movement, locomotor time 20.60.61.51.20.40.5
Total resting periods, locomotor time 20.80.92.01.40.50.6
Rest time, locomotor task time 20.10.10.20.4-0.50.0
Distance moved, locomotor task time 20.20.20.5-0.70.3-0.1
Vertical activity count, locomotor time 20.20.20.6-0.7-0.2-0.1
Weight adjusted by age0.40.40.60.50.60.8
Seeking ratio, delayed vs. immediate footshock0.10.10.20.20.10.4
Locomotion in novel chamber0.20.30.50.00.60.7
Locomotion in novel chamber post-restriction1.82.12.91.71.21.4
Progressive ratio0.50.61.0-1.0-0.8-0.3
Food seeking constrained by brief footshock14.818.021.0-4.6-3.9-4.2
Seeking ratio, punishment vs. effort1.01.22.0-1.0-0.9-1.4
Run reversals in cocaine runway, females0.30.30.5-0.2-0.6-0.7
Run reversals in cocaine runway, males1.11.11.3-1.1-0.9-1.2
Latency to leave start box in cocaine runway0.00.00.00.10.10.0
Latency to leave start box in cocaine runway, F0.10.10.20.30.40.3
Latency to leave start box in cocaine runway, M0.80.80.9-0.8-1.0-0.9
Cd content in liver0.40.40.80.90.7-0.2
Co content in liver4.45.25.9-2.4-2.3-2.1
Cu content in liver0.10.10.4-0.6-0.10.0
Fe content in liver0.20.20.4-0.3-0.4-0.7
K content in liver2.12.12.51.41.61.4
Mg content in liver1.92.02.21.51.41.4
Mn content in liver0.30.30.60.80.40.5
Na content in liver1.92.12.2-1.5-1.4-1.4
Rb content in liver0.40.50.80.70.90.6
Se content in liver0.60.70.90.70.91.0
Sr content in liver0.10.10.20.40.20.3
Zn content in liver1.21.32.20.51.21.5