Morc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000026236	0.05	0.03	3.4e-04	0.02	0.02	0.01	0.01	2.9e-03	5.5e-03	2.1e-02	1.4e-02
2	BLA	gene expression	ENSRNOG00000026236	0.11	0.08	2.7e-03	0.01	0.03	0.02	0.02	6.6e-02	6.9e-03	1.9e-02	4.3e-02
3	LHb	gene expression	ENSRNOG00000026236	0.27	0.14	4.4e-03	0.01	0.03	0.04	0.02	1.6e-01	5.8e-02	4.4e-02	1.2e-01
4	Liver	alternative polyA	ENSRNOT00000076473	0.03	0.02	4.1e-03	0.02	0.02	0.02	0.02	9.5e-04	1.6e-03	4.6e-03	2.9e-03
5	Liver	gene expression	ENSRNOG00000026236	0.07	0.04	4.3e-07	0.04	0.05	0.04	0.04	1.9e-05	4.4e-06	1.5e-05	9.1e-06
6	PL	intron excision ratio	chr11:33163168:33163995	0.04	0.03	1.3e-03	0.04	0.02	0	0.02	9.0e-04	1.8e-02	1.5e-01	7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.8	2.5	4.1	1.6	1.4	1.7	-1.5	2.0	-1.0
BMI without tail	0.1	0.2	0.4	0.6	0.5	0.2	-0.5	0.2	-0.1
Body weight	0.3	1.2	2.0	1.0	0.9	1.2	-1.0	1.4	-0.7
Epididymis fat weight	3.6	8.4	14.0	2.0	2.1	3.7	-1.9	3.7	-3.2
Glucose	1.2	1.9	7.1	-0.4	0.6	1.3	0.5	1.3	-2.7
Heart weight	2.1	3.1	4.9	2.1	2.2	1.3	-2.1	1.2	-1.4
Left kidney weight	0.5	1.5	4.7	1.3	-0.5	0.2	-1.4	0.2	2.2
Right kidney weight	0.5	1.5	6.9	0.7	-1.0	-0.3	-0.8	-0.1	2.6
Tail length	0.7	2.2	3.2	-1.3	-1.8	-1.4	1.4	-1.6	1.4
Length with tail	0.1	0.3	0.5	-0.4	-0.7	-0.5	0.3	-0.5	0.5
Length without tail	0.0	0.1	0.3	-0.0	0.1	0.3	-0.2	0.5	-0.0
Liver weight, left	0.1	0.2	0.6	-0.2	-0.8	-0.1	0.1	-0.1	0.5
Liver weight, right	0.1	0.2	0.2	0.4	0.5	0.1	-0.4	0.4	0.5
Parametrial fat weight	2.5	4.9	8.0	2.0	2.3	2.4	-2.0	2.8	-1.6
Retroperitoneal fat weight	1.2	4.0	7.0	1.2	2.0	2.3	-1.1	2.4	-2.6
Intraocular pressure	0.4	0.5	1.2	0.8	1.1	0.2	-0.8	-0.1	-0.7
Extensor digitorum longus weight	2.1	8.5	21.6	1.4	2.9	3.1	-1.3	2.8	-4.6
Soleus weight	0.6	1.6	3.5	0.5	0.7	1.7	-0.5	1.9	-1.5
Tibialis anterior weight	4.0	13.8	33.9	1.8	3.8	3.8	-1.8	3.6	-5.8
Tibia length	0.0	0.0	0.1	0.2	0.1	0.2	-0.3	0.1	0.1
Number of licking bursts	0.3	0.3	0.6	0.7	0.5	-0.4	-0.7	-0.3	0.6
Food consumed during 24 hour testing period	0.8	1.0	1.1	-1.0	-1.0	-1.1	1.0	-0.9	1.0
Times rat made contact with spout	6.8	7.7	11.9	-1.9	-2.6	-3.2	1.9	-3.2	3.4
Mean time between licks in bursts	1.1	1.5	4.2	-0.3	-0.4	-1.4	0.3	-1.5	2.1
Mean num. licks in bursts	2.6	3.1	4.1	-2.0	-2.0	-1.6	2.0	-1.6	1.1
Std. dev. time between licks in bursts	1.6	2.0	2.7	-1.6	-1.6	-1.3	1.6	-1.4	0.9
Water consumed over 24 hours	0.4	0.5	1.0	-0.6	-1.0	-0.4	0.6	-0.3	0.9
Indifference point 0 sec	3.4	5.5	6.8	-2.5	-2.6	-2.3	2.6	-2.1	1.8
Indifference point AUC	0.6	0.7	1.2	-1.0	-0.6	0.7	1.0	0.5	-1.1
Indifference point function ln k	0.5	0.7	1.6	-0.2	-1.0	-0.9	0.2	-1.0	1.2
Indifference point function log k	0.5	0.7	1.6	-0.2	-1.0	-0.9	0.2	-1.0	1.2
Delay discounting total patch changes 0 sec	2.8	4.5	6.0	-2.4	-2.4	-2.0	2.4	-1.8	1.4
Delay discounting total patch changes 12 sec	1.0	1.3	3.0	-1.7	-1.1	-0.2	1.7	-0.5	-0.7
Delay discounting total patch changes 18 sec	1.1	1.4	3.0	-1.7	-1.5	-0.2	1.7	-0.4	-0.4
Delay discounting total patch changes 24 sec	0.4	0.5	1.0	-0.6	-1.0	0.8	0.7	0.6	-0.5
Delay discounting total patch changes 6 sec	2.3	3.5	7.3	-2.6	-1.9	-1.2	2.7	-1.4	-0.0
Delay discounting time to switch 0 sec	0.7	1.0	2.1	1.3	1.5	0.5	-1.2	0.7	-0.0
Delay discounting water rate 0 sec	0.6	1.0	2.0	-1.3	-0.7	-0.1	1.3	-0.2	-1.4
Delay discounting water rate 12 sec	1.7	2.5	3.6	-1.4	-1.9	-1.6	1.4	-1.3	1.9
Delay discounting water rate 18 sec	0.4	0.6	0.8	0.7	0.7	0.8	-0.8	0.7	-0.9
Delay discounting water rate 24 sec	0.2	0.3	1.1	0.0	-1.1	0.2	-0.1	0.2	0.9
Delay discounting water rate 6 sec	0.1	0.1	0.7	-0.2	-0.8	0.1	0.3	-0.1	0.3
Locomotor activity	1.2	2.0	7.8	-0.3	-1.3	-1.1	0.3	-0.9	2.8
Locomotor testing distance	1.3	2.1	3.9	-1.1	-1.5	-1.6	1.1	-1.4	2.0
Locomotor testing rearing	0.2	0.3	1.6	0.2	-0.5	-0.4	-0.2	-0.1	1.3
Light reinforcement 1	0.6	1.0	1.7	1.1	0.7	1.3	-1.1	1.2	-0.1
Light reinforcement 2	3.0	4.0	7.4	1.1	1.3	2.7	-1.1	2.6	-2.4
Reaction time number correct	0.2	0.2	0.5	-0.6	-0.7	0.1	0.6	-0.1	-0.1
Reaction time mean minus median	0.9	1.2	1.8	-1.1	-1.3	-0.9	1.1	-1.2	0.7
Reaction time mean minus median AUC	1.1	1.4	2.8	-1.5	-1.7	-0.6	1.5	-1.0	0.1
Reaction time num false alarms	1.2	1.6	3.9	-0.4	-0.4	-1.7	0.4	-1.5	2.0
Reaction time num false alarms AUC	1.0	1.4	5.1	0.0	-0.3	-1.3	-0.0	-1.1	2.3
Reaction time trials correct on left	0.2	0.2	0.5	-0.6	-0.7	0.1	0.6	-0.1	-0.1
Reaction time trials on left	0.2	0.2	0.5	-0.6	-0.7	0.1	0.7	-0.1	-0.1
Reaction time mean	0.2	0.2	0.6	0.4	0.8	-0.1	-0.3	-0.3	-0.5
Reaction time mean AUC	0.1	0.1	0.4	-0.2	0.2	-0.5	0.2	-0.7	-0.3
Median of all reaction times	0.7	1.0	2.5	1.1	1.6	0.3	-1.1	0.3	-0.9
Reaction time omissions	0.0	0.1	0.2	0.2	0.2	0.5	-0.2	0.1	0.0
Reaction time false alarm rate	0.8	1.2	3.9	0.2	0.1	-1.3	-0.3	-1.1	2.0
Reaction time premature initiation rate	1.3	1.7	2.9	1.1	1.0	1.7	-1.1	1.6	-1.2
Reaction time premature initiations	0.5	0.7	1.9	0.3	0.2	1.4	-0.3	1.2	-1.0
Std. dev. reaction times	0.7	0.9	1.8	-0.9	-0.9	-1.0	0.9	-1.3	0.8
Reaction time trials completed	0.2	0.2	0.5	-0.6	-0.7	0.1	0.7	-0.1	-0.1
Reaction time trials AUC	0.1	0.2	0.3	-0.5	-0.5	0.2	0.6	0.1	-0.3
Social response proportion	0.3	0.3	0.8	0.0	-0.6	-0.6	-0.0	-0.4	0.9
Social responses	0.2	0.2	1.0	0.4	-0.4	-0.2	-0.4	0.1	1.0
Social time	0.1	0.1	0.2	0.1	-0.3	0.5	-0.1	0.4	-0.2
Conditioned locomotion	0.5	0.6	0.9	-0.5	-0.8	-0.9	0.5	-0.8	1.0
Cocaine response after cond. corrected	0.9	1.1	1.9	-1.3	-1.4	-0.6	1.3	-0.6	0.5
Cocaine response after cond. not corrected	1.1	1.2	2.4	-1.3	-1.5	-0.7	1.3	-0.6	0.9
Cocaine response before conditioning	0.1	0.1	0.2	0.3	-0.1	0.3	-0.3	0.3	0.4
Saline control response	0.2	0.2	0.4	-0.6	-0.3	0.2	0.6	0.2	-0.6
Condit. Reinf. active minus inactive responses	0.6	0.7	2.0	0.2	-0.3	1.4	-0.2	1.3	-0.4
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.8	1.3	0.5	1.3	-1.3	1.4	0.0
Condit. Reinf. active responses	0.4	0.6	0.8	-0.9	-0.6	0.8	0.9	0.6	-0.8
Condit. Reinf. inactive responses	0.9	1.1	2.8	-1.7	-0.8	-0.2	1.7	-0.3	-0.7
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.4	-0.3	0.8	0.4	0.6	-0.8
Condit. Reinf. lever reinforcers received	0.5	0.6	1.0	-0.7	-0.5	1.0	0.7	0.9	-0.9
Pavlov. Cond. lever latency	0.6	0.9	1.8	0.3	0.3	-1.3	-0.3	-1.2	1.3
Pavlov. Cond. magazine entry latency	0.2	0.3	1.0	-0.6	-1.0	0.1	0.6	0.0	0.2
Pavlov. Cond. change in total contacts	0.7	1.0	2.5	0.4	0.2	1.6	-0.4	1.5	-1.0
Pavlov. Cond. index score	0.4	0.5	1.2	-0.9	-1.1	0.2	0.9	0.2	-0.4
Pavlov. Cond. latency score	0.3	0.4	1.1	-0.7	-1.1	0.2	0.7	0.1	-0.0
Pavlov. Cond. lever contacts	0.4	0.6	1.5	-0.0	-0.2	1.2	0.0	1.1	-0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	-0.3	0.1	-0.8	0.3	-0.7	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.6	-0.1	-0.1	0.6	-0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	-0.9	-1.1	0.3	0.9	0.2	-0.2
Pavlov. Cond. response bias	0.3	0.5	1.1	-0.2	-0.4	1.0	0.2	1.0	-0.8
Conditioned reinforcement - actives	0.3	0.3	0.5	0.5	-0.3	0.7	-0.5	0.6	0.7
Conditioned reinforcement - inactives	2.4	2.7	4.5	-1.4	-2.1	-1.4	1.3	-1.7	1.8
Conditioned locomotion	0.2	0.3	0.7	-0.3	-0.5	-0.3	0.2	-0.8	0.6
Intermittent access intake day 1-15 change	1.9	1.9	2.6	-1.3	-1.6	-1.4	1.3	-1.6	0.9
Intermittent access intake escalation	2.1	2.0	3.0	-1.4	-1.6	-1.5	1.4	-1.7	0.8
Intermittent access intake escalation 2	2.9	2.9	4.1	-2.0	-2.0	-1.2	2.0	-1.7	0.8
Intermitt. access day 1 inactive lever presses	2.7	2.9	4.3	-1.3	-1.8	-1.7	1.4	-1.8	2.1
Intermitt. access day 15 inactive lever presses	1.5	1.6	4.2	-1.3	-2.1	-0.7	1.1	-1.2	0.9
Intermitt. access escalation Index	0.2	0.1	0.3	-0.2	-0.5	-0.5	0.3	-0.4	0.1
Intermittent access day 1 total infusions	0.5	0.5	1.8	-0.4	-1.3	-0.1	0.3	-0.4	0.9
Intermittent access day 15 total infusions	4.6	5.2	7.8	-2.3	-2.8	-2.0	2.1	-2.5	1.9
Intermittent access terminal intake (last 3 days)	3.5	3.8	6.3	-1.8	-2.5	-1.5	1.6	-2.2	1.8
Intermittent access total infusions	2.4	2.6	4.9	-1.5	-2.2	-1.1	1.4	-1.6	1.6
Intermittent access day 1 locomotion	1.0	1.0	2.8	-0.4	-1.5	-0.6	0.3	-0.8	1.7
Intermittent access day 15 total locomotion	2.5	2.7	5.5	-1.9	-2.4	-1.0	1.8	-1.4	1.0
Intermittent access total locomotion	3.7	4.2	9.1	-2.1	-3.0	-1.2	1.9	-1.7	1.9
Intermittent access standard deviation	2.2	2.4	3.3	-1.7	-1.3	-1.6	1.7	-1.8	0.9
Cocaine induced anxiety	0.3	0.4	0.9	-0.9	-0.9	-0.3	0.6	-0.5	0.2
Post-drug Anxiety	0.5	0.5	1.4	-1.2	-1.0	0.3	0.8	0.1	-0.3
Baseline Anxiety	0.0	0.0	0.2	0.0	0.1	0.1	0.4	0.3	0.0
Lifetime Intake	0.7	0.8	1.5	-0.7	-1.2	-0.6	0.5	-1.0	1.0
Incentive Sensitization - Responses	1.9	1.9	3.0	-1.7	-1.7	-0.8	1.7	-1.3	0.3
Incentive Sensitization - Breakpoint	2.3	2.3	3.6	-1.9	-1.9	-0.9	1.8	-1.5	0.3
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.4	-0.4	-0.0	-0.5	-0.1	0.8
Progressive ratio test 1 breakpoint	0.3	0.3	0.9	0.5	-0.2	-0.1	-0.6	-0.2	1.0
Progressive ratio test 1 inactive lever presses	1.1	1.1	2.0	-0.8	-1.1	-1.1	0.8	-1.4	1.0
Progressive ratio test 2 active lever presses	2.4	2.6	3.9	-1.5	-2.0	-1.4	1.4	-1.9	1.3
Progressive ratio test 2 breakpoint	2.6	2.9	4.0	-1.7	-2.0	-1.5	1.6	-2.0	1.3
Progressive ratio test 2 inactive lever presses	4.9	5.6	11.9	-2.5	-3.5	-1.6	2.4	-2.3	1.6
Total sessions with >9 infusions	0.3	0.4	0.7	0.8	0.3	-0.3	-0.7	-0.4	0.8
Short access day 1 total inactive lever presses	2.3	2.6	4.1	-1.4	-1.5	-1.7	1.3	-2.0	1.6
Short access day 10 total inactive lever presses	0.4	0.4	1.1	-0.8	-0.1	-0.5	0.7	-1.0	-0.3
Short access day 1 total infusions	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.5	0.1
Short access day 10 total infusions	0.4	0.4	1.0	0.9	0.8	0.2	-1.0	-0.1	-0.2
Short access total infusions	0.4	0.5	1.1	1.0	0.7	0.4	-1.0	0.2	0.1
Short access day 1 locomotion	0.5	0.5	1.0	0.5	0.3	-0.7	-0.5	-1.0	1.0
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	-0.1	0.3	-0.4	0.1	0.2
Short access total locomotion	0.4	0.4	0.8	0.9	0.4	0.5	-0.9	0.2	0.2
Compulsive drug intake	1.2	1.2	2.9	0.7	0.2	1.7	-0.6	1.7	-0.9
One hour access (0.3 mA shock)	1.4	1.6	4.0	-1.2	-2.0	-0.5	1.2	-1.0	1.2
One hour access (shock baseline)	3.4	3.9	5.1	-2.1	-2.3	-1.7	2.0	-2.2	1.4
Number of responses in last shaping day	0.5	0.5	0.9	1.0	0.4	-0.1	-1.0	-0.3	0.9
Context. condit. distance diff. score	0.3	0.3	1.0	-0.3	-1.0	0.4	0.4	0.5	0.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.5	-0.3	-0.0
Locomotion distance, session 1	0.2	0.3	0.4	-0.6	-0.5	0.6	0.6	0.5	-0.2
Locomotion velocity, session 2	0.2	0.2	0.6	-0.7	-0.5	-0.0	0.8	0.1	0.1
Locomotion distance, session 2	0.1	0.2	0.3	0.4	0.1	0.4	-0.3	0.6	0.5
Locomotion velocity, session 3	1.2	1.4	3.6	-1.3	-0.2	1.0	1.3	0.5	-1.9
Locomotion distance, session 3	0.5	0.6	1.1	0.5	1.0	0.9	-0.5	0.7	-0.7
Stereotopy head waving bouts, day 3	1.3	1.5	2.5	-1.4	0.4	-1.4	1.4	-1.6	-0.9
Stereotopy head waving duration, day 3	0.9	1.1	1.6	-1.2	0.3	-1.1	1.2	-1.3	-1.0
Locomotion velocity, session 7	0.8	0.8	2.1	-0.5	-0.8	-0.9	0.5	-1.0	1.5
Locomotion distance, session 7	0.6	0.8	4.3	0.5	-0.2	-0.2	-0.4	-0.2	2.1
Stereotopy head waving bouts, day 7	1.6	1.8	3.6	-1.9	-0.7	-0.7	1.8	-0.7	-1.5
Stereotopy head waving duration, day 7	1.4	1.8	3.5	-1.9	-1.1	-0.1	1.8	-0.1	-1.6
Locomotion velocity, session 8	0.9	1.0	2.8	-1.1	-0.1	0.7	1.1	0.7	-1.7
Locomotion distance, session 8	0.3	0.4	0.7	-0.0	-0.7	0.8	0.1	0.9	0.6
Degree of sensitization distance	1.0	1.0	3.8	-0.3	-1.0	-0.8	0.3	-0.7	1.9
Degree of sensitization stereotypy	1.0	1.1	3.3	-1.1	-0.5	0.5	1.0	0.6	-1.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.1	-0.2	0.0
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.8	-0.7	-0.8	-0.9	0.7	-0.8	0.5
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	-0.2	0.3	-0.1	0.1	-0.1
Condit. Reinf. inactive responses	0.0	0.1	0.2	-0.0	-0.0	0.5	0.1	0.2	-0.3
Incentive salience index mean	0.0	0.0	0.1	0.0	-0.3	-0.2	0.0	-0.1	0.3
Condit. Reinf. lever presses	0.2	0.2	0.6	-0.2	-0.8	-0.4	0.3	-0.2	0.7
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.2	-0.2	0.7	-0.3	0.7	0.3
Time in novel zone, hab. session 1	0.7	0.7	2.1	0.6	1.4	0.0	-0.7	-0.2	-1.1
Total zone transitions, hab. session 1	0.7	1.0	3.8	-0.4	-1.1	-0.5	0.4	-0.3	2.0
Total locomotion distance, hab. session 1	0.6	0.9	3.2	-0.3	-0.9	-0.9	0.2	-0.7	1.8
Locomotion velocity, hab. session 1	0.7	1.0	3.6	-0.2	-0.9	-1.0	0.3	-0.7	1.9
Time in familiar zone, hab. session 2	1.4	1.4	3.1	1.1	0.5	1.8	-1.1	1.6	-0.5
Time in novel zone, hab. session 2	0.6	0.6	1.5	-0.4	0.0	-1.2	0.5	-1.2	0.2
Total zone transitions, hab. session 2	0.6	0.7	2.4	0.6	-0.4	0.7	-0.5	0.8	1.5
Total locomotion distance, hab. session 2	0.8	1.0	4.6	0.8	-0.4	0.0	-0.8	0.2	2.1
Locomotion velocity, hab. session 2	0.7	1.0	4.7	0.7	-0.3	-0.1	-0.7	0.3	2.2
Novel to familiar place preference ratio	0.3	0.3	1.1	0.4	1.0	-0.5	-0.5	-0.3	0.1
Novelty place preference	0.6	0.6	2.1	0.8	1.5	-0.1	-0.9	0.1	-0.3
Time in novel zone, NPP test	0.7	0.8	2.3	1.0	1.5	0.1	-1.0	0.3	-0.5
Total zone transitions, NPP test	0.2	0.3	0.7	-0.2	-0.8	0.6	0.3	0.5	0.6
Total locomotion distance, NPP test	0.1	0.2	0.7	0.4	0.1	-0.0	-0.4	0.1	0.8
Locomotion velocity, NPP test	0.2	0.2	1.2	0.3	-0.0	-0.2	-0.3	-0.0	1.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	0.5	0.2	-0.5	0.2	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	0.2	-0.0	-0.5	-0.2	-0.5	0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	-0.4	-0.1	-0.1	0.1	0.1
Pavlov. Cond. index score	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.2	-0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.1	-0.3	-0.4	0.1	-0.3	0.4
Pavlov. Cond. lever contacts	0.5	0.6	1.3	-0.9	-1.1	-0.6	1.0	-0.5	0.3
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.1	-0.2	0.3	0.2	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	1.6	2.0	7.0	-1.4	-0.3	0.2	1.6	-0.3	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.3	0.3
Pavlov. Cond. response bias	0.2	0.3	0.4	-0.4	-0.7	-0.5	0.4	-0.6	0.6
Bone: apparent density	0.2	0.3	0.7	0.7	0.9	0.0	-0.8	0.1	0.1
Bone surface	2.3	4.0	6.5	1.1	1.6	2.5	-1.2	2.5	-2.5
Bone volume	1.6	2.6	3.6	1.2	1.5	1.9	-1.2	1.9	-1.9
Bone: connectivity density	0.6	1.0	1.4	0.9	1.2	0.9	-0.9	1.0	-0.8
Bone: cortical apparent density	0.1	0.2	0.3	0.5	0.4	0.3	-0.6	0.3	-0.1
Bone: cortical area	0.2	0.3	0.8	-0.7	-0.9	0.0	0.7	0.1	-0.1
Bone: cortical porosity	0.2	0.2	0.5	-0.0	-0.4	-0.6	0.1	-0.7	0.7
Bone: cortical porosity	0.1	0.2	0.6	0.2	-0.3	-0.2	-0.2	-0.3	0.8
Bone: cortical thickness	2.1	3.5	5.3	-1.6	-2.3	-1.9	1.7	-1.8	1.8
Bone: cortical thickness	0.2	0.2	0.6	0.0	-0.5	-0.6	-0.1	-0.6	0.7
Bone: cortical tissue density	0.2	0.2	0.4	0.6	0.5	0.4	-0.7	0.4	-0.2
Bone: elastic displacement	0.2	0.3	0.7	-0.0	-0.1	-0.7	0.1	-0.9	0.6
Bone: elastic work	0.2	0.3	0.6	-0.5	-0.4	-0.6	0.6	-0.8	-0.0
Bone: endosteal estimation	3.6	7.8	11.2	2.1	2.8	3.4	-2.2	3.3	-2.9
Bone: endosteal perimeter	1.2	2.4	5.1	0.6	0.9	2.2	-0.6	2.2	-1.7
Bone: final force	0.1	0.2	0.6	-0.2	-0.0	0.6	0.2	0.5	-0.8
Bone: final moment	0.1	0.2	0.6	-0.3	-0.2	0.5	0.3	0.5	-0.8
Bone: marrow area	3.6	7.8	11.5	2.1	2.7	3.4	-2.1	3.3	-2.9
Bone: maximum diameter	0.4	0.7	1.6	-0.2	-0.0	1.2	0.1	1.2	-1.3
Bone: maximum force	0.1	0.2	0.8	-0.2	0.3	0.3	0.2	0.3	-0.9
Bone: maximum moment	0.1	0.2	0.7	-0.2	0.2	0.4	0.2	0.3	-0.9
Bone: minimum diameter	1.8	3.4	8.4	0.5	1.4	2.3	-0.4	2.1	-2.9
Bone: periosteal estimation	1.0	2.1	3.6	0.7	1.1	1.9	-0.7	1.8	-1.8
Bone: periosteal perimeter	0.3	0.5	1.1	-0.4	-0.2	1.0	0.4	1.0	-0.8
Bone: post-yield work	0.3	0.4	1.5	-0.8	-0.1	-0.0	0.8	0.2	-1.2
Bone: stiffness	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.3	-0.1	0.1
Bone: tissue strength	0.2	0.2	0.4	-0.2	-0.4	-0.5	0.2	-0.6	0.6
Bone: trabecular number	0.2	0.3	0.7	0.8	0.7	0.3	-0.8	0.4	0.1
Bone: trabecular spacing	0.8	1.0	2.7	-0.1	-1.2	-0.9	0.0	-0.9	1.7
Bone: trabecular thickness	0.3	0.4	1.0	0.3	0.8	0.4	-0.3	0.5	-1.0
Bone: trabecular tissue density	0.3	0.5	2.2	0.3	-0.5	-0.2	-0.4	-0.2	1.5
Breakpoint value in progressive ratio session	0.2	0.2	0.7	-0.3	-0.8	0.4	0.3	0.1	0.3
Distance traveled before self-admin	0.1	0.1	0.4	0.1	-0.3	0.7	-0.1	0.4	-0.3
Distance traveled after self-admin	1.4	1.5	2.4	1.5	1.6	0.9	-1.5	1.1	-0.4
Delta time in closed arm before/after self-admin	1.1	1.1	1.8	1.3	1.3	0.7	-1.3	0.9	-0.0
Delta time in open arm before/after self-admin	0.2	0.2	0.7	0.2	0.3	0.5	-0.2	0.3	-0.8
Diff in mean of infusions in LGA sessions	1.3	1.4	2.8	-1.7	-1.6	-0.2	1.7	-0.3	-0.5
Extinction: sum of active levers before priming	0.6	0.6	1.3	-1.0	-1.1	0.4	1.0	0.1	-0.3
Active lever presses in extinction session 6	4.2	4.0	5.8	-2.4	-1.6	-1.9	2.4	-2.4	0.6
Delta distance traveled before/after self-admin	1.4	1.5	2.8	1.7	1.5	0.6	-1.7	1.0	0.3
Delta ambulatory time before/after self-admin	1.5	1.6	2.8	1.7	1.4	0.7	-1.7	1.2	0.4
Time in closed arm before self-admin	0.6	0.7	1.5	0.7	0.4	1.2	-0.7	1.0	-0.8
Time in closed arm after self-admin	6.1	6.4	9.4	3.1	2.6	2.3	-3.1	2.6	-0.5
Time in open arm before self-admin	0.1	0.1	0.3	-0.0	0.0	-0.3	0.0	-0.1	0.6
Time in open arm after self-admin	0.8	0.9	1.8	-1.3	-1.0	-0.4	1.3	-0.5	-0.3
Sum of active levers in priming session hrs 5-6	1.4	1.4	2.6	-1.6	-1.0	-0.9	1.6	-1.1	-0.1
Time to tail flick, vehicle, before self-admin	2.9	2.9	6.2	-0.9	-0.6	-2.5	0.9	-2.4	1.9
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.7	1.1	1.0	1.9	-1.1	1.5	-1.6
Time to tail flick, test, before self-admin	0.6	0.5	1.0	1.0	0.5	0.3	-1.0	0.1	1.0
Time to tail flick, test, after self-admin	1.0	1.0	1.9	1.4	0.4	0.7	-1.4	0.9	0.7
Delta time to tail flick, vehicle, before/after SA	3.6	3.5	7.5	1.1	0.8	2.7	-1.1	2.4	-2.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	-0.2	0.2	-0.1	0.3	-0.2
Ambulatory time before self-admin	0.2	0.3	0.7	-0.2	-0.2	0.7	0.2	0.4	-0.8
Ambulatory time after self-admin	0.9	1.0	1.5	1.0	1.2	1.0	-1.0	1.1	-0.6
Total heroin consumption	1.7	2.1	5.8	-1.2	-2.4	-0.7	1.2	-0.7	1.7
Area under the delay curve	1.8	1.9	3.1	1.8	0.7	1.6	-1.8	1.5	0.4
Delay disc. indifference point, 0s delay	1.6	1.7	2.7	1.5	0.8	1.5	-1.5	1.6	-0.3
Delay disc. indifference point, 16s delay	0.7	0.7	1.4	1.2	0.9	0.6	-1.2	0.5	0.1
Delay disc. indifference point, 2s delay	1.8	2.0	3.1	1.8	1.1	1.4	-1.8	1.5	-0.3
Delay disc. indifference point, 24s delay	0.4	0.4	1.2	0.7	-0.2	0.3	-0.7	0.1	1.1
Delay disc. indifference point, 4s delay	1.8	1.9	2.9	1.6	0.8	1.6	-1.6	1.7	-0.1
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	0.9	-0.0	0.7	-0.9	0.7	0.7
Delay discount exponential model param	1.6	1.7	2.7	-1.6	-0.6	-1.5	1.6	-1.4	-0.4
Delay discount hyperbolic model param	1.8	1.9	3.2	-1.8	-0.8	-1.6	1.8	-1.5	-0.2
Fecal boli incidents, locomotor time 1	0.9	1.0	1.6	1.1	-0.2	1.3	-1.1	1.1	0.6
Change in fecal boli incidents, locomotor task	1.1	1.1	2.5	-0.3	-0.9	-1.2	0.3	-1.2	1.6
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.6	-1.2	-1.2	-1.3	1.2	-1.1	0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.4	-0.2	-0.3
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.4	-0.1	-0.1
Rest time, locomotor task time 1	2.4	2.6	4.7	1.6	1.0	2.2	-1.6	2.1	-0.3
Distance moved, locomotor task time 1	1.3	1.4	3.9	-0.7	-0.0	-2.0	0.7	-1.9	0.2
Vertical activity count, locomotor time 1	1.2	1.3	2.6	-1.3	-0.4	-1.6	1.3	-1.3	-0.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.0	0.5	1.0	0.3	-0.5	0.2	-0.9
Bouts of movement, locomotor time 2	1.2	1.3	2.9	0.2	-0.2	1.7	-0.2	1.7	-1.4
Total resting periods, locomotor time 2	0.6	0.6	1.5	-0.0	-0.6	1.2	0.0	1.2	-0.7
Rest time, locomotor task time 2	0.5	0.6	1.7	-0.7	-1.3	0.0	0.7	-0.0	1.0
Distance moved, locomotor task time 2	0.9	1.1	3.3	1.0	1.8	-0.2	-1.0	-0.2	-1.1
Vertical activity count, locomotor time 2	0.9	1.0	2.3	0.8	1.5	0.3	-0.8	0.6	-1.4
Weight adjusted by age	0.4	0.5	1.5	-0.2	-0.8	-0.7	0.2	-0.5	1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.5	1.2	1.2	-0.2	-1.2	-0.0	0.0
Locomotion in novel chamber	0.5	0.6	1.1	-0.8	-1.0	-0.7	0.8	-0.8	0.6
Locomotion in novel chamber post-restriction	1.0	1.2	2.5	0.9	1.5	0.6	-0.9	0.7	-1.6
Progressive ratio	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.3	-0.2	-0.2
Food seeking constrained by brief footshock	0.9	1.1	2.2	-0.6	-0.5	-1.5	0.6	-1.2	1.5
Seeking ratio, punishment vs. effort	0.3	0.4	1.3	0.0	0.1	-0.7	-0.1	-0.7	1.2
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.4	-0.7	-0.3	-0.1	-0.4	0.7
Run reversals in cocaine runway, males	0.5	0.5	1.3	-0.9	-1.2	-0.1	0.8	-0.1	0.2
Latency to leave start box in cocaine runway	0.3	0.4	0.6	0.8	0.8	0.3	-0.8	0.5	-0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.6	1.1	1.2	-0.0	-1.1	0.2	0.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.6	-0.0	0.0	0.8	0.0	0.8	-0.7
Cd content in liver	1.8	1.9	3.9	-1.0	-0.7	-1.9	1.0	-2.0	1.2
Co content in liver	0.2	0.2	0.3	0.5	0.3	0.5	-0.5	0.5	-0.2
Cu content in liver	0.1	0.1	0.2	-0.3	-0.1	-0.4	0.3	-0.5	-0.3
Fe content in liver	1.5	1.8	2.7	-1.5	-0.4	-1.5	1.5	-1.6	-0.8
K content in liver	1.0	1.0	1.9	0.9	1.4	0.7	-0.9	0.8	-1.0
Mg content in liver	0.5	0.5	1.3	0.4	1.1	0.3	-0.4	0.2	-1.1
Mn content in liver	1.7	1.9	3.4	1.2	1.1	1.7	-1.2	1.8	-1.0
Na content in liver	1.0	1.1	3.9	-0.4	0.3	1.0	0.4	1.0	-2.0
Rb content in liver	0.1	0.2	0.3	0.3	-0.1	-0.5	-0.3	-0.5	0.6
Se content in liver	1.7	2.0	4.0	-1.4	-0.6	-2.0	1.4	-2.0	0.3
Sr content in liver	0.8	0.7	2.5	-0.1	-0.7	-0.9	0.1	-0.8	1.6
Zn content in liver	1.1	1.2	1.7	-1.3	-1.2	-1.1	1.3	-1.0	0.6