ENSRNOG00000025388

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr6:24743562:24747293 0.05 0.05 6.5e-05 0.03 0.03 0.04 0.03 9.2e-05 1.1e-04 7.7e-05 1.3e-04
2 Liver gene expression ENSRNOG00000025388 0.03 0.03 9.2e-03 0.01 0.01 0.01 0.01 1.5e-02 1.9e-02 1.2e-02 1.7e-02
3 Liver isoform ratio ENSRNOT00000034712 0.05 0.05 1.5e-04 0.04 0.03 0.03 0.03 7.5e-05 1.0e-04 1.1e-04 1.3e-04
4 Liver isoform ratio ENSRNOT00000084751 0.04 0.05 2.5e-04 0.03 0.03 0.03 0.03 1.5e-04 1.8e-04 1.8e-04 2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.20.71.11.00.00.9-0.9
BMI without tail0.10.30.30.60.60.5-0.5
Body weight1.56.37.42.7-1.92.7-2.7
Epididymis fat weight14.132.835.96.0-5.05.9-5.9
Glucose0.20.20.40.60.10.5-0.5
Heart weight6.49.212.73.6-1.33.4-3.4
Left kidney weight0.10.20.50.2-0.70.2-0.2
Right kidney weight1.64.67.91.8-2.81.9-1.9
Tail length0.10.20.30.60.10.5-0.5
Length with tail1.45.25.42.3-2.12.3-2.3
Length without tail0.71.61.81.2-1.31.2-1.2
Liver weight, left1.11.82.11.4-1.11.4-1.4
Liver weight, right7.312.114.73.8-2.43.8-3.8
Parametrial fat weight4.58.710.43.2-2.03.2-3.2
Retroperitoneal fat weight20.367.372.78.5-7.28.5-8.5
Intraocular pressure6.38.911.32.8-3.42.9-2.9
Extensor digitorum longus weight3.915.618.1-4.33.0-4.24.2
Soleus weight3.610.413.0-3.62.0-3.53.5
Tibialis anterior weight3.311.312.9-3.62.6-3.63.6
Tibia length1.95.36.92.6-1.32.5-2.5
Number of licking bursts0.10.10.2-0.3-0.4-0.20.2
Food consumed during 24 hour testing period0.30.40.5-0.60.7-0.60.6
Times rat made contact with spout1.61.82.4-1.60.5-1.51.5
Mean time between licks in bursts2.43.43.61.9-1.61.9-1.9
Mean num. licks in bursts0.10.20.2-0.40.4-0.40.4
Std. dev. time between licks in bursts0.00.00.00.20.10.2-0.2
Water consumed over 24 hours1.72.12.2-1.51.2-1.51.5
Indifference point 0 sec0.40.60.70.8-0.80.8-0.8
Indifference point AUC3.54.26.3-1.82.5-1.91.9
Indifference point function ln k0.00.10.10.1-0.40.2-0.2
Indifference point function log k0.00.10.10.1-0.40.2-0.2
Delay discounting total patch changes 0 sec0.30.50.60.7-0.80.7-0.7
Delay discounting total patch changes 12 sec0.60.81.01.0-0.70.9-0.9
Delay discounting total patch changes 18 sec0.10.10.40.10.6-0.00.0
Delay discounting total patch changes 24 sec0.50.71.01.0-0.20.9-0.9
Delay discounting total patch changes 6 sec0.00.00.00.10.20.1-0.1
Delay discounting time to switch 0 sec0.40.62.10.1-1.40.3-0.3
Delay discounting water rate 0 sec0.20.41.4-0.01.2-0.20.2
Delay discounting water rate 12 sec1.52.32.81.7-1.11.6-1.6
Delay discounting water rate 18 sec0.71.01.11.0-1.11.0-1.0
Delay discounting water rate 24 sec2.23.03.11.7-1.71.8-1.8
Delay discounting water rate 6 sec1.01.52.01.4-0.61.3-1.3
Locomotor activity1.42.27.00.6-2.60.8-0.8
Locomotor testing distance0.30.51.6-0.4-1.3-0.20.2
Locomotor testing rearing0.50.70.9-1.00.5-0.90.9
Light reinforcement 14.48.18.6-2.92.7-2.92.9
Light reinforcement 24.35.75.8-2.42.4-2.42.4
Reaction time number correct0.60.90.9-1.01.0-0.90.9
Reaction time mean minus median0.10.10.40.1-0.60.1-0.1
Reaction time mean minus median AUC0.20.20.50.3-0.70.3-0.3
Reaction time num false alarms0.10.10.5-0.2-0.7-0.20.2
Reaction time num false alarms AUC0.20.20.6-0.4-0.8-0.30.3
Reaction time trials correct on left0.60.90.9-1.01.0-0.90.9
Reaction time trials on left0.70.91.0-1.01.0-1.01.0
Reaction time mean1.21.71.81.3-1.21.3-1.3
Reaction time mean AUC1.11.41.51.2-1.11.2-1.2
Median of all reaction times1.21.61.81.3-1.01.3-1.3
Reaction time omissions0.10.10.1-0.30.2-0.30.3
Reaction time false alarm rate0.30.41.50.2-1.20.3-0.3
Reaction time premature initiation rate0.50.71.70.5-1.30.6-0.6
Reaction time premature initiations0.10.10.6-0.1-0.80.0-0.0
Std. dev. reaction times0.40.60.60.7-0.80.7-0.7
Reaction time trials completed0.70.91.0-1.01.0-1.01.0
Reaction time trials AUC0.81.21.2-1.11.1-1.11.1
Social response proportion0.20.30.40.6-0.20.5-0.5
Social responses0.10.10.20.30.50.2-0.2
Social time0.30.40.60.80.80.5-0.5
Conditioned locomotion2.42.93.7-1.91.0-1.91.9
Cocaine response after cond. corrected0.70.81.1-1.10.1-1.01.0
Cocaine response after cond. not corrected1.51.72.3-1.50.5-1.41.4
Cocaine response before conditioning1.31.62.2-1.21.5-1.21.2
Saline control response0.91.21.8-1.01.3-1.01.0
Condit. Reinf. active minus inactive responses3.13.84.7-2.21.3-2.12.1
Condit. Reinf. active-inactive response ratio0.80.81.0-1.00.6-1.01.0
Condit. Reinf. active responses2.43.34.1-2.01.2-2.02.0
Condit. Reinf. inactive responses1.31.62.0-1.40.7-1.41.4
Condit. Reinf. lever presses1.62.22.8-1.70.9-1.61.6
Condit. Reinf. lever reinforcers received2.13.03.6-1.91.2-1.91.9
Pavlov. Cond. lever latency1.52.12.41.6-1.01.5-1.5
Pavlov. Cond. magazine entry latency0.60.71.5-0.61.2-0.70.7
Pavlov. Cond. change in total contacts0.50.70.9-1.00.4-0.90.9
Pavlov. Cond. index score1.21.61.6-1.21.2-1.31.3
Pavlov. Cond. latency score1.31.71.9-1.21.4-1.31.3
Pavlov. Cond. lever contacts0.70.91.2-1.10.5-1.11.1
Pavlov. Cond. magazine entry number0.30.30.60.4-0.80.5-0.5
Pavlov. Cond. intertrial magazine entries3.95.05.12.2-2.32.3-2.3
Pavlov. Cond. lever-magazine prob. diff.0.91.21.3-1.01.1-1.11.1
Pavlov. Cond. response bias1.52.02.4-1.61.0-1.51.5
Conditioned reinforcement - actives2.62.56.1-1.02.5-1.21.2
Conditioned reinforcement - inactives3.13.54.6-1.72.1-1.81.8
Conditioned locomotion0.50.52.0-0.11.4-0.30.3
Intermittent access intake day 1-15 change2.12.16.8-0.62.6-0.80.8
Intermittent access intake escalation1.71.76.0-0.32.4-0.50.5
Intermittent access intake escalation 21.51.56.00.22.4-0.10.1
Intermitt. access day 1 inactive lever presses0.30.30.8-0.20.9-0.30.3
Intermitt. access day 15 inactive lever presses13.014.325.7-3.05.1-3.33.3
Intermitt. access escalation Index0.60.52.10.21.40.0-0.0
Intermittent access day 1 total infusions5.05.76.0-2.42.3-2.42.4
Intermittent access day 15 total infusions4.65.110.1-1.73.2-1.91.9
Intermittent access terminal intake (last 3 days)3.84.28.4-1.52.9-1.71.7
Intermittent access total infusions2.02.22.3-1.41.5-1.51.5
Intermittent access day 1 locomotion1.91.92.2-1.51.0-1.51.5
Intermittent access day 15 total locomotion1.01.01.7-0.91.3-0.90.9
Intermittent access total locomotion0.30.30.4-0.50.6-0.50.5
Intermittent access standard deviation0.40.41.1-0.31.1-0.40.4
Cocaine induced anxiety1.31.54.0-0.72.0-0.90.9
Post-drug Anxiety0.40.40.60.8-0.00.7-0.7
Baseline Anxiety2.32.54.71.2-2.21.4-1.4
Lifetime Intake2.83.13.4-1.71.8-1.81.8
Incentive Sensitization - Responses0.20.20.70.20.90.1-0.1
Incentive Sensitization - Breakpoint0.30.30.80.30.90.2-0.2
Progressive ratio test 1 active lever presses1.51.62.7-1.01.6-1.11.1
Progressive ratio test 1 breakpoint1.31.32.2-0.91.5-1.11.1
Progressive ratio test 1 inactive lever presses5.76.112.0-1.93.5-2.12.1
Progressive ratio test 2 active lever presses0.30.31.1-0.11.0-0.30.3
Progressive ratio test 2 breakpoint0.30.41.2-0.21.1-0.30.3
Progressive ratio test 2 inactive lever presses4.04.610.3-1.53.2-1.71.7
Total sessions with >9 infusions1.41.61.7-1.21.2-1.31.3
Short access day 1 total inactive lever presses5.86.48.7-2.32.9-2.42.4
Short access day 10 total inactive lever presses1.21.31.7-1.11.3-1.11.1
Short access day 1 total infusions4.95.27.0-2.02.7-2.22.2
Short access day 10 total infusions3.33.63.9-1.91.7-2.02.0
Short access total infusions2.62.93.5-1.51.9-1.71.7
Short access day 1 locomotion6.56.87.6-2.52.8-2.62.6
Short access day 10 total locomotion0.90.91.2-0.91.1-0.90.9
Short access total locomotion0.50.50.6-0.60.8-0.70.7
Compulsive drug intake1.00.92.60.5-1.60.7-0.7
One hour access (0.3 mA shock)2.22.63.3-1.41.8-1.61.6
One hour access (shock baseline)1.92.23.1-1.31.8-1.41.4
Number of responses in last shaping day0.80.82.0-0.51.4-0.70.7
Context. condit. distance diff. score0.00.00.00.1-0.00.1-0.1
Locomotion velocity, session 10.20.20.80.10.9-0.00.0
Locomotion distance, session 12.12.82.8-1.71.6-1.71.7
Locomotion velocity, session 20.20.30.30.5-0.60.5-0.5
Locomotion distance, session 20.10.10.3-0.10.6-0.10.1
Locomotion velocity, session 30.70.81.1-0.81.0-0.90.9
Locomotion distance, session 31.11.21.4-1.01.2-1.11.1
Stereotopy head waving bouts, day 31.82.12.2-1.41.4-1.51.5
Stereotopy head waving duration, day 30.10.10.1-0.30.3-0.30.3
Locomotion velocity, session 71.61.72.8-1.11.7-1.21.2
Locomotion distance, session 70.30.41.1-0.31.1-0.40.4
Stereotopy head waving bouts, day 70.00.00.00.1-0.20.1-0.1
Stereotopy head waving duration, day 70.20.30.4-0.60.3-0.60.6
Locomotion velocity, session 80.40.51.5-0.41.2-0.50.5
Locomotion distance, session 80.40.70.9-0.71.0-0.80.8
Degree of sensitization distance0.70.70.80.9-0.60.9-0.9
Degree of sensitization stereotypy0.30.30.60.4-0.70.5-0.5
Condit. Reinf. active minus inactive responses0.80.91.50.8-1.20.9-0.9
Condit. Reinf. active-inactive response ratio1.11.11.80.9-1.41.0-1.0
Condit. Reinf. active responses0.10.20.2-0.4-0.4-0.40.4
Condit. Reinf. inactive responses1.51.82.2-1.50.9-1.51.5
Incentive salience index mean0.10.10.2-0.1-0.5-0.10.1
Condit. Reinf. lever presses0.40.50.8-0.9-0.1-0.80.8
Time in familiar zone, hab. session 10.50.50.70.8-0.30.8-0.8
Time in novel zone, hab. session 10.90.80.90.9-0.90.9-0.9
Total zone transitions, hab. session 10.10.10.2-0.40.3-0.40.4
Total locomotion distance, hab. session 10.20.30.5-0.50.7-0.50.5
Locomotion velocity, hab. session 11.11.61.6-1.31.2-1.31.3
Time in familiar zone, hab. session 20.10.10.5-0.10.7-0.20.2
Time in novel zone, hab. session 21.01.01.80.8-1.30.9-0.9
Total zone transitions, hab. session 20.10.10.1-0.4-0.1-0.30.3
Total locomotion distance, hab. session 20.20.30.3-0.60.4-0.50.5
Locomotion velocity, hab. session 20.40.50.6-0.80.4-0.80.8
Novel to familiar place preference ratio1.31.42.01.0-1.41.1-1.1
Novelty place preference2.02.02.61.3-1.61.4-1.4
Time in novel zone, NPP test2.22.32.71.4-1.71.5-1.5
Total zone transitions, NPP test1.42.02.2-1.51.2-1.51.5
Total locomotion distance, NPP test2.02.72.9-1.71.5-1.71.7
Locomotion velocity, NPP test3.14.44.9-2.21.8-2.22.2
Pavlov. Cond. lever latency2.02.52.61.6-1.51.6-1.6
Pavlov. Cond. magazine entry latency0.10.10.2-0.20.4-0.20.2
Pavlov. Cond. change in total contacts0.00.00.0-0.20.0-0.20.2
Pavlov. Cond. index score0.91.21.3-1.01.1-1.11.1
Pavlov. Cond. latency score0.91.21.4-1.01.2-1.11.1
Pavlov. Cond. lever contacts1.01.21.4-1.20.9-1.21.2
Pavlov. Cond. magazine entry number0.60.81.00.8-1.00.8-0.8
Pavlov. Cond. intertrial magazine entries0.81.01.4-1.20.4-1.11.1
Pavlov. Cond. lever-magazine prob. diff.1.62.02.2-1.51.2-1.51.5
Pavlov. Cond. response bias1.51.92.0-1.41.3-1.41.4
Bone: apparent density5.18.59.3-3.12.5-3.03.0
Bone surface3.15.45.5-2.32.3-2.32.3
Bone volume3.25.45.5-2.32.3-2.32.3
Bone: connectivity density4.77.48.4-2.92.2-2.92.9
Bone: cortical apparent density0.20.30.5-0.7-0.1-0.60.6
Bone: cortical area0.30.50.5-0.70.6-0.70.7
Bone: cortical porosity1.31.41.5-1.21.1-1.21.2
Bone: cortical porosity1.31.41.4-1.21.2-1.21.2
Bone: cortical thickness0.00.00.00.1-0.20.1-0.1
Bone: cortical thickness1.61.92.0-1.41.3-1.41.4
Bone: cortical tissue density0.20.20.3-0.6-0.1-0.50.5
Bone: elastic displacement0.50.50.8-0.9-0.1-0.80.8
Bone: elastic work0.70.91.3-1.10.3-1.11.1
Bone: endosteal estimation0.51.01.2-1.01.1-1.01.0
Bone: endosteal perimeter0.20.30.3-0.60.5-0.60.6
Bone: final force0.20.30.3-0.50.6-0.50.5
Bone: final moment0.20.30.3-0.50.5-0.50.5
Bone: marrow area0.51.01.0-1.01.0-1.01.0
Bone: maximum diameter0.91.61.8-1.31.1-1.31.3
Bone: maximum force0.00.00.1-0.20.3-0.20.2
Bone: maximum moment0.00.10.1-0.30.3-0.30.3
Bone: minimum diameter0.00.10.10.4-0.10.3-0.3
Bone: periosteal estimation0.61.31.4-1.11.1-1.21.2
Bone: periosteal perimeter0.20.30.3-0.60.4-0.60.6
Bone: post-yield work0.40.60.6-0.80.6-0.80.8
Bone: stiffness0.00.00.00.10.20.0-0.0
Bone: tissue strength1.41.32.30.9-1.51.0-1.0
Bone: trabecular number4.06.36.8-2.62.2-2.62.6
Bone: trabecular spacing3.74.74.92.1-2.22.2-2.2
Bone: trabecular thickness0.91.11.3-1.01.1-1.01.0
Bone: trabecular tissue density0.20.30.5-0.50.7-0.50.5
Breakpoint value in progressive ratio session0.60.70.9-1.00.4-1.01.0
Distance traveled before self-admin0.00.00.0-0.20.1-0.20.2
Distance traveled after self-admin0.40.50.60.8-0.30.7-0.7
Delta time in closed arm before/after self-admin0.00.00.00.10.20.1-0.1
Delta time in open arm before/after self-admin0.20.20.3-0.6-0.1-0.50.5
Diff in mean of infusions in LGA sessions0.30.30.6-0.40.8-0.50.5
Extinction: sum of active levers before priming0.30.30.5-0.7-0.2-0.60.6
Active lever presses in extinction session 60.60.61.4-0.41.2-0.60.6
Delta distance traveled before/after self-admin0.91.01.41.2-0.11.1-1.1
Delta ambulatory time before/after self-admin0.10.20.20.40.50.3-0.3
Time in closed arm before self-admin0.60.70.80.9-0.80.9-0.9
Time in closed arm after self-admin1.91.92.01.4-1.41.4-1.4
Time in open arm before self-admin0.00.00.1-0.3-0.1-0.20.2
Time in open arm after self-admin2.12.32.9-1.71.1-1.61.6
Sum of active levers in priming session hrs 5-60.80.80.9-1.00.8-0.90.9
Time to tail flick, vehicle, before self-admin2.62.62.71.6-1.51.7-1.7
Time to tail flick, vehicle, after self-admin5.15.55.82.3-2.42.3-2.3
Time to tail flick, test, before self-admin0.40.40.5-0.70.5-0.70.7
Time to tail flick, test, after self-admin0.20.20.30.4-0.50.4-0.4
Delta time to tail flick, vehicle, before/after SA0.00.00.00.2-0.20.2-0.2
Delta time to tail flick, test, before/after SA0.40.30.4-0.50.6-0.60.6
Ambulatory time before self-admin0.10.10.2-0.40.2-0.40.4
Ambulatory time after self-admin0.20.20.30.60.30.5-0.5
Total heroin consumption2.83.33.5-1.81.7-1.91.9
Area under the delay curve1.31.45.7-0.3-2.40.1-0.1
Delay disc. indifference point, 0s delay5.45.913.11.7-3.61.9-1.9
Delay disc. indifference point, 16s delay0.70.72.5-0.6-1.6-0.30.3
Delay disc. indifference point, 2s delay0.40.40.90.5-1.00.5-0.5
Delay disc. indifference point, 24s delay2.32.26.4-1.2-2.5-0.80.8
Delay disc. indifference point, 4s delay0.10.10.3-0.2-0.5-0.10.1
Delay disc. indifference point, 8s delay1.31.35.3-0.3-2.3-0.00.0
Delay discount exponential model param1.21.34.90.52.20.2-0.2
Delay discount hyperbolic model param0.90.93.30.61.80.3-0.3
Fecal boli incidents, locomotor time 10.20.30.4-0.6-0.0-0.60.6
Change in fecal boli incidents, locomotor task4.74.54.62.1-2.02.2-2.2
Time >=10cm from walls, locomotor time 11.11.14.00.2-2.00.4-0.4
Bouts of movement, locomotor time 11.92.13.0-1.70.4-1.61.6
Total resting periods, locomotor time 12.32.63.4-1.90.8-1.81.8
Rest time, locomotor task time 10.00.10.1-0.20.2-0.20.2
Distance moved, locomotor task time 11.21.41.51.2-1.21.1-1.1
Vertical activity count, locomotor time 10.50.60.60.7-0.80.7-0.7
Time >=10cm from walls, locomotor time 20.10.10.1-0.30.0-0.30.3
Bouts of movement, locomotor time 20.20.20.50.2-0.70.3-0.3
Total resting periods, locomotor time 20.00.00.0-0.1-0.1-0.10.1
Rest time, locomotor task time 21.31.51.9-1.40.8-1.31.3
Distance moved, locomotor task time 20.91.01.31.1-0.71.1-1.1
Vertical activity count, locomotor time 20.40.50.70.8-0.40.7-0.7
Weight adjusted by age0.10.10.30.20.60.1-0.1
Seeking ratio, delayed vs. immediate footshock0.30.41.60.11.3-0.00.0
Locomotion in novel chamber1.01.21.31.1-1.01.1-1.1
Locomotion in novel chamber post-restriction3.84.57.11.8-2.72.0-2.0
Progressive ratio0.20.20.70.20.90.0-0.0
Food seeking constrained by brief footshock3.94.75.4-2.12.3-2.22.2
Seeking ratio, punishment vs. effort0.50.71.0-1.0-0.0-0.90.9
Run reversals in cocaine runway, females0.70.72.30.3-1.50.4-0.4
Run reversals in cocaine runway, males0.20.20.8-0.3-0.9-0.20.2
Latency to leave start box in cocaine runway1.11.22.3-0.81.5-1.01.0
Latency to leave start box in cocaine runway, F0.91.01.2-0.91.1-1.01.0
Latency to leave start box in cocaine runway, M1.11.12.5-0.71.6-0.80.8
Cd content in liver0.00.00.0-0.1-0.2-0.10.1
Co content in liver4.85.66.6-2.61.7-2.62.6
Cu content in liver0.00.00.0-0.20.1-0.20.2
Fe content in liver0.00.00.10.10.30.1-0.1
K content in liver0.10.10.20.20.50.1-0.1
Mg content in liver0.10.10.10.40.20.3-0.3
Mn content in liver0.70.81.0-0.81.0-0.80.8
Na content in liver0.91.01.9-0.81.4-0.80.8
Rb content in liver0.00.00.00.1-0.20.1-0.1
Se content in liver0.20.30.40.60.10.6-0.6
Sr content in liver0.20.20.50.3-0.70.3-0.3
Zn content in liver1.11.21.41.2-0.91.2-1.2