Rinl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	ENSRNOT00000036907	0.02	0.02	6.5e-03	0.02	0.01	0.02	0.01	6.4e-03	3.7e-02	6.6e-03	3.2e-02
2	Brain	intron excision ratio	chr1:84086426:84086850	0.03	0.02	3.2e-03	0.03	0.02	0.03	0.02	1.7e-03	6.0e-03	4.8e-04	2.3e-03
3	Liver	gene expression	ENSRNOG00000025354	0.16	0.1	4.6e-15	0.09	0.1	0.08	0.09	3.4e-10	5.7e-11	1.5e-09	1.3e-10
4	Liver	mRNA stability	ENSRNOG00000025354	0.1	0.07	4.0e-11	0.08	0.06	0.08	0.07	4.4e-09	1.0e-07	7.2e-09	1.5e-08
5	PL	gene expression	ENSRNOG00000025354	0.04	0.03	8.8e-04	0.04	0.03	0.01	0.03	7.4e-04	3.4e-03	3.2e-02	2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.1	0.3	0.6	-0.4	0.4	-0.7	0.4	-0.8
BMI without tail	0.2	0.3	0.6	0.8	-0.5	0.4	-0.8	0.3
Body weight	2.1	9.1	13.0	3.0	-1.7	3.6	-3.0	3.3
Epididymis fat weight	0.0	0.0	0.1	-0.2	0.3	-0.2	0.2	-0.2
Glucose	0.4	0.6	0.8	-0.8	0.9	-0.3	0.8	-0.8
Heart weight	1.0	1.4	1.8	1.1	-1.4	1.1	-1.1	1.2
Left kidney weight	2.9	8.4	9.8	3.0	-2.4	3.1	-3.0	3.0
Right kidney weight	3.8	10.8	12.6	3.3	-2.7	3.5	-3.3	3.5
Tail length	4.1	12.2	15.9	3.5	-2.4	4.0	-3.5	3.9
Length with tail	6.2	22.6	30.7	4.7	-3.2	5.5	-4.7	5.3
Length without tail	3.1	6.7	9.4	2.5	-1.7	3.1	-2.5	2.9
Liver weight, left	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.2	-0.2
Liver weight, right	0.0	0.0	0.1	0.0	0.1	0.3	0.0	0.1
Parametrial fat weight	0.4	0.7	0.9	-0.9	0.6	-0.8	0.9	-0.9
Retroperitoneal fat weight	1.1	3.8	5.3	-2.0	2.3	-1.6	2.0	-1.7
Intraocular pressure	0.1	0.2	0.6	-0.3	0.8	-0.1	0.2	-0.5
Extensor digitorum longus weight	0.1	0.6	0.8	-0.7	0.5	-0.9	0.7	-0.9
Soleus weight	1.0	3.0	4.0	-1.7	1.6	-2.0	1.6	-1.7
Tibialis anterior weight	0.0	0.0	0.1	0.0	-0.1	-0.3	-0.0	0.0
Tibia length	2.2	6.1	7.0	2.6	-2.1	2.6	-2.5	2.5
Number of licking bursts	1.3	1.5	2.2	-1.3	0.7	-1.2	1.3	-1.5
Food consumed during 24 hour testing period	0.5	0.6	0.8	0.7	-0.9	0.9	-0.7	0.6
Times rat made contact with spout	0.4	0.4	0.6	-0.7	0.6	-0.8	0.7	-0.6
Mean time between licks in bursts	0.2	0.3	0.3	0.5	-0.5	0.5	-0.5	0.6
Mean num. licks in bursts	0.4	0.4	0.9	0.7	-0.2	0.5	-0.7	0.9
Std. dev. time between licks in bursts	0.4	0.5	0.7	0.8	-0.6	0.6	-0.8	0.8
Water consumed over 24 hours	1.0	1.2	1.5	1.0	-1.2	1.2	-1.0	1.0
Indifference point 0 sec	0.4	0.6	0.8	0.8	-0.9	0.7	-0.8	0.7
Indifference point AUC	1.1	1.3	3.6	-1.0	1.9	-0.9	1.0	-0.6
Indifference point function ln k	1.0	1.4	3.2	1.0	-1.8	1.1	-1.0	0.8
Indifference point function log k	1.0	1.4	3.2	1.0	-1.8	1.1	-1.0	0.8
Delay discounting total patch changes 0 sec	0.4	0.7	0.8	0.8	-0.9	0.8	-0.8	0.8
Delay discounting total patch changes 12 sec	0.2	0.2	0.4	0.4	0.3	0.4	-0.4	0.7
Delay discounting total patch changes 18 sec	0.8	1.0	3.5	-0.7	1.9	-0.8	0.7	-0.3
Delay discounting total patch changes 24 sec	0.4	0.4	0.8	0.6	0.2	0.7	-0.6	0.9
Delay discounting total patch changes 6 sec	0.0	0.1	0.1	0.2	0.3	0.1	-0.2	0.3
Delay discounting time to switch 0 sec	1.8	2.7	4.4	-1.6	2.1	-1.4	1.6	-1.4
Delay discounting water rate 0 sec	0.2	0.3	0.6	-0.7	0.1	-0.3	0.7	-0.8
Delay discounting water rate 12 sec	0.7	1.1	2.4	0.9	-0.6	1.5	-0.9	1.1
Delay discounting water rate 18 sec	0.4	0.5	0.9	-0.7	-0.2	-0.6	0.7	-0.9
Delay discounting water rate 24 sec	0.7	0.9	1.4	0.9	-1.2	1.1	-0.9	0.8
Delay discounting water rate 6 sec	0.2	0.2	0.5	0.4	-0.6	0.7	-0.4	0.3
Locomotor activity	1.0	1.5	3.5	-1.2	1.9	-1.0	1.2	-0.8
Locomotor testing distance	1.1	1.8	2.4	-1.3	1.6	-1.3	1.3	-1.2
Locomotor testing rearing	1.8	2.9	3.8	-1.6	2.0	-1.9	1.6	-1.4
Light reinforcement 1	0.5	1.0	2.4	-0.9	1.5	-0.6	0.9	-0.6
Light reinforcement 2	6.0	7.9	10.2	-2.9	2.0	-2.8	2.9	-3.2
Reaction time number correct	0.1	0.2	0.4	0.4	-0.6	0.3	-0.4	0.4
Reaction time mean minus median	0.2	0.3	0.5	0.4	-0.5	0.7	-0.4	0.5
Reaction time mean minus median AUC	0.4	0.6	0.9	0.6	-0.8	1.0	-0.6	0.7
Reaction time num false alarms	0.5	0.7	1.3	-0.6	0.1	-1.2	0.6	-1.1
Reaction time num false alarms AUC	0.7	1.0	1.9	-0.8	0.2	-1.4	0.8	-1.3
Reaction time trials correct on left	0.1	0.2	0.4	0.4	-0.6	0.3	-0.4	0.4
Reaction time trials on left	0.1	0.2	0.4	0.3	-0.7	0.3	-0.3	0.3
Reaction time mean	0.0	0.0	0.1	-0.2	-0.1	0.0	0.2	-0.3
Reaction time mean AUC	0.1	0.1	0.2	-0.3	-0.1	-0.1	0.3	-0.5
Median of all reaction times	0.1	0.1	0.3	-0.3	0.0	-0.3	0.3	-0.6
Reaction time omissions	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.2	-0.5
Reaction time false alarm rate	0.8	1.2	1.8	-1.0	0.6	-1.3	1.0	-1.4
Reaction time premature initiation rate	0.0	0.0	0.0	-0.0	0.1	-0.1	0.0	-0.0
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	0.2
Std. dev. reaction times	0.1	0.2	0.4	0.4	-0.4	0.6	-0.4	0.4
Reaction time trials completed	0.1	0.2	0.4	0.3	-0.7	0.3	-0.3	0.3
Reaction time trials AUC	0.1	0.1	0.3	0.3	-0.6	0.2	-0.3	0.2
Social response proportion	5.3	5.8	6.6	2.4	-2.6	2.3	-2.4	2.3
Social responses	0.1	0.1	0.3	0.2	-0.3	0.5	-0.2	0.2
Social time	0.1	0.1	0.3	0.3	-0.0	0.5	-0.3	0.6
Conditioned locomotion	0.7	0.8	1.2	0.9	-0.9	1.1	-0.9	0.8
Cocaine response after cond. corrected	0.6	0.7	1.0	0.8	-1.0	0.9	-0.8	0.7
Cocaine response after cond. not corrected	1.1	1.2	1.4	1.1	-1.2	1.1	-1.2	0.9
Cocaine response before conditioning	2.0	2.5	3.1	1.7	-1.3	1.4	-1.8	1.6
Saline control response	0.5	0.6	0.9	0.9	-0.9	0.3	-0.9	0.7
Condit. Reinf. active minus inactive responses	4.7	5.8	6.6	2.6	-2.4	2.2	-2.5	2.4
Condit. Reinf. active-inactive response ratio	3.2	3.4	3.8	2.0	-1.8	1.5	-1.9	1.9
Condit. Reinf. active responses	5.2	7.2	8.1	2.8	-2.6	2.5	-2.8	2.7
Condit. Reinf. inactive responses	1.3	1.6	1.8	1.4	-1.0	1.2	-1.4	1.3
Condit. Reinf. lever presses	6.8	9.4	10.2	3.2	-2.8	3.1	-3.2	3.1
Condit. Reinf. lever reinforcers received	6.3	8.8	9.7	3.1	-2.8	2.9	-3.1	2.9
Pavlov. Cond. lever latency	3.0	4.1	4.6	-2.1	1.7	-2.1	2.1	-2.1
Pavlov. Cond. magazine entry latency	1.8	2.0	3.0	1.4	-1.2	1.7	-1.4	1.3
Pavlov. Cond. change in total contacts	5.8	8.1	9.0	3.0	-2.5	2.8	-3.0	2.9
Pavlov. Cond. index score	2.7	3.5	4.1	2.0	-1.6	2.0	-1.9	1.9
Pavlov. Cond. latency score	2.6	3.3	4.0	1.9	-1.5	2.0	-1.8	1.8
Pavlov. Cond. lever contacts	2.8	3.9	4.4	2.1	-1.7	2.0	-2.1	2.0
Pavlov. Cond. magazine entry number	1.0	1.2	1.7	-1.1	0.9	-1.3	1.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.1	-1.1	0.8	-0.7	1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.0	4.7	2.1	-1.7	2.2	-2.1	2.0
Pavlov. Cond. response bias	3.3	4.6	5.0	2.2	-1.9	2.2	-2.2	2.2
Conditioned reinforcement - actives	1.5	1.5	4.1	1.1	-2.0	0.7	-1.1	0.5
Conditioned reinforcement - inactives	1.7	2.0	3.3	1.3	-0.7	1.8	-1.3	1.5
Conditioned locomotion	0.5	0.6	1.3	-0.6	-0.6	-0.9	0.6	-1.2
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.7	0.1	0.9	-0.7	1.1
Intermittent access intake escalation	0.5	0.5	0.7	0.7	-0.3	0.8	-0.8	0.8
Intermittent access intake escalation 2	1.9	1.9	3.0	1.5	-0.7	1.3	-1.5	1.7
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.8	0.5	-0.7	0.9	-0.5	0.4
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	0.4	-0.4	0.8	-0.4	0.3
Intermitt. access escalation Index	0.9	0.8	2.3	0.9	-1.5	0.2	-0.9	0.4
Intermittent access day 1 total infusions	1.2	1.4	5.5	0.8	-2.3	0.5	-0.8	0.1
Intermittent access day 15 total infusions	1.6	1.8	3.1	1.3	-1.8	1.2	-1.3	1.0
Intermittent access terminal intake (last 3 days)	1.9	2.1	2.3	1.4	-1.5	1.4	-1.4	1.3
Intermittent access total infusions	1.8	2.0	4.5	1.3	-2.1	1.1	-1.3	0.8
Intermittent access day 1 locomotion	2.5	2.6	10.1	1.1	-3.2	0.4	-1.1	0.0
Intermittent access day 15 total locomotion	0.3	0.4	1.7	0.2	-1.3	0.1	-0.2	-0.2
Intermittent access total locomotion	0.5	0.6	2.4	0.0	-1.5	-0.3	-0.0	-0.7
Intermittent access standard deviation	3.2	3.4	4.9	1.9	-0.9	1.9	-1.9	2.2
Cocaine induced anxiety	0.1	0.1	0.3	-0.3	0.5	-0.2	0.3	0.1
Post-drug Anxiety	0.5	0.5	0.8	-0.8	0.5	-0.9	0.8	-0.6
Baseline Anxiety	0.1	0.2	0.6	0.2	-0.8	-0.2	-0.2	-0.3
Lifetime Intake	1.0	1.1	3.6	0.9	-1.9	0.6	-0.9	0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.0	-0.1	0.2	0.0	-0.0
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.3	0.2	-0.1	0.3	-0.2
Progressive ratio test 1 active lever presses	4.8	4.9	10.3	2.2	-3.2	1.7	-2.2	1.3
Progressive ratio test 1 breakpoint	4.8	4.9	9.0	2.2	-3.0	1.9	-2.2	1.6
Progressive ratio test 1 inactive lever presses	1.5	1.6	4.5	1.1	-2.1	0.9	-1.1	0.5
Progressive ratio test 2 active lever presses	2.1	2.2	5.1	1.4	-2.3	1.2	-1.4	0.8
Progressive ratio test 2 breakpoint	2.2	2.4	5.6	1.4	-2.4	1.2	-1.4	0.8
Progressive ratio test 2 inactive lever presses	3.7	4.3	5.9	2.1	-2.4	2.0	-2.1	1.7
Total sessions with >9 infusions	0.7	0.8	2.9	0.7	-1.7	0.1	-0.7	-0.1
Short access day 1 total inactive lever presses	0.6	0.6	0.9	0.8	-0.9	0.8	-0.8	0.6
Short access day 10 total inactive lever presses	0.3	0.3	0.7	0.5	-0.8	0.6	-0.5	0.3
Short access day 1 total infusions	1.1	1.2	2.7	1.0	-1.6	0.8	-1.0	0.6
Short access day 10 total infusions	0.3	0.4	1.6	0.3	-1.3	-0.1	-0.3	-0.2
Short access total infusions	0.6	0.6	2.7	0.4	-1.6	-0.0	-0.4	-0.2
Short access day 1 locomotion	0.7	0.8	1.4	-0.8	0.0	-1.2	0.8	-1.1
Short access day 10 total locomotion	2.3	2.5	7.8	1.4	-2.8	0.7	-1.4	0.5
Short access total locomotion	1.2	1.3	5.4	0.6	-2.3	-0.2	-0.6	-0.3
Compulsive drug intake	0.2	0.2	0.2	0.5	-0.3	0.2	-0.5	0.5
One hour access (0.3 mA shock)	2.1	2.4	4.3	1.6	-2.1	1.3	-1.6	1.1
One hour access (shock baseline)	0.5	0.6	1.3	0.7	-1.1	0.7	-0.7	0.4
Number of responses in last shaping day	2.1	2.1	2.9	1.4	-1.0	1.7	-1.4	1.7
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	-0.3
Locomotion velocity, session 1	2.6	2.8	3.4	-1.6	1.6	-1.8	1.7	-1.7
Locomotion distance, session 1	0.6	0.8	1.1	0.8	-0.8	1.0	-0.8	1.0
Locomotion velocity, session 2	0.5	0.6	0.8	-0.8	0.9	-0.7	0.7	-0.8
Locomotion distance, session 2	0.5	0.8	1.0	-0.8	0.8	-1.0	0.9	-0.8
Locomotion velocity, session 3	0.1	0.1	0.1	-0.3	0.2	0.2	0.4	-0.3
Locomotion distance, session 3	6.2	6.8	7.9	2.7	-2.3	2.8	-2.6	2.6
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.5	0.4	-0.8	0.5	-0.5
Stereotopy head waving duration, day 3	2.3	2.8	3.3	-1.7	1.5	-1.8	1.7	-1.7
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	0.3	0.3	0.1	-0.1
Locomotion distance, session 7	0.1	0.1	0.3	0.4	-0.1	0.5	-0.4	0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.1	0.2	-0.2	0.1	-0.1
Stereotopy head waving duration, day 7	0.9	1.1	1.5	-1.0	0.9	-1.2	0.9	-1.0
Locomotion velocity, session 8	2.8	3.3	3.6	-1.9	1.8	-1.7	1.8	-1.9
Locomotion distance, session 8	0.4	0.6	0.9	-0.6	0.7	-0.9	0.7	-0.7
Degree of sensitization distance	3.6	3.6	3.8	-1.9	1.8	-1.9	1.9	-1.9
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.1	-0.4	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.1	-0.4	0.2	-0.3
Condit. Reinf. active responses	0.8	1.0	1.2	-1.0	0.7	-1.0	1.1	-1.1
Condit. Reinf. inactive responses	0.7	0.8	1.0	-1.0	0.8	-0.8	1.0	-1.0
Incentive salience index mean	0.0	0.0	0.0	-0.0	-0.1	0.2	0.0	-0.1
Condit. Reinf. lever presses	0.1	0.2	0.4	0.3	-0.3	0.6	-0.3	0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.5	-0.1	0.3	-0.6	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.1	-0.2	0.4	-0.2
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.8	-0.5	0.4	-0.7	0.8
Total locomotion distance, hab. session 1	2.1	3.0	3.9	1.8	-1.5	1.4	-1.8	2.0
Locomotion velocity, hab. session 1	0.8	1.1	1.6	1.1	-1.0	0.8	-1.1	1.3
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.5	-0.3	0.6	-0.5	0.6
Time in novel zone, hab. session 2	0.6	0.6	0.9	-0.9	0.5	-0.8	0.9	-0.7
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.3	-0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.6	-0.8	0.6	-0.6	0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.5	-0.7	0.5	-0.6	0.8
Novel to familiar place preference ratio	0.5	0.6	1.1	0.8	-0.4	0.7	-0.7	1.0
Novelty place preference	0.5	0.5	0.9	0.7	-0.3	0.7	-0.6	1.0
Time in novel zone, NPP test	0.2	0.2	0.5	0.5	-0.2	0.5	-0.4	0.7
Total zone transitions, NPP test	0.2	0.3	0.4	-0.5	0.5	-0.5	0.6	-0.6
Total locomotion distance, NPP test	1.2	1.6	2.0	1.3	-1.2	1.1	-1.3	1.4
Locomotion velocity, NPP test	1.6	2.2	2.7	1.6	-1.4	1.3	-1.5	1.6
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.6	0.3	-0.5	0.5	-0.4
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.2	0.1	-0.2	0.2	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3	0.0
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.2	0.2	-0.3	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	-0.3	0.3	-0.4	0.2
Pavlov. Cond. lever contacts	0.8	1.0	1.2	1.1	-0.7	1.1	-1.1	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.0	0.0	0.2	-0.0	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.3	0.5	-0.5	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.5	-0.4	0.4	-0.6	0.3
Pavlov. Cond. response bias	0.1	0.2	0.2	0.5	-0.4	0.4	-0.5	0.3
Bone: apparent density	0.1	0.2	0.4	-0.3	0.7	-0.1	0.2	-0.4
Bone surface	0.2	0.4	0.8	0.6	-0.2	0.9	-0.8	0.5
Bone volume	0.3	0.4	0.8	0.7	-0.2	0.9	-0.8	0.5
Bone: connectivity density	0.6	0.9	1.1	-1.0	0.9	-0.8	0.9	-1.0
Bone: cortical apparent density	2.4	3.1	3.8	-1.7	1.7	-2.0	1.7	-1.7
Bone: cortical area	2.0	3.1	3.8	1.9	-1.3	1.7	-1.9	1.9
Bone: cortical porosity	0.5	0.6	0.7	-0.8	0.7	-0.8	0.7	-0.7
Bone: cortical porosity	0.6	0.6	0.8	-0.9	0.8	-0.8	0.8	-0.8
Bone: cortical thickness	0.9	1.6	2.1	1.4	-0.8	1.2	-1.3	1.3
Bone: cortical thickness	0.0	0.0	0.1	-0.1	0.2	-0.0	0.2	-0.1
Bone: cortical tissue density	2.8	3.6	4.3	-1.8	1.8	-2.1	1.9	-1.8
Bone: elastic displacement	0.1	0.1	0.2	-0.3	0.4	-0.2	0.2	-0.3
Bone: elastic work	2.2	2.9	3.6	1.8	-1.3	1.9	-1.7	1.8
Bone: endosteal estimation	1.0	2.1	2.3	1.5	-1.3	1.3	-1.5	1.5
Bone: endosteal perimeter	0.9	1.9	1.9	1.4	-1.3	1.3	-1.4	1.4
Bone: final force	1.6	2.6	3.1	1.7	-1.0	1.7	-1.6	1.8
Bone: final moment	2.4	4.0	4.7	2.2	-1.4	2.1	-2.1	2.2
Bone: marrow area	1.0	2.2	2.4	1.5	-1.3	1.4	-1.6	1.6
Bone: maximum diameter	1.5	2.7	3.2	1.8	-1.3	1.8	-1.7	1.6
Bone: maximum force	2.8	4.8	5.8	2.4	-1.7	2.1	-2.3	2.3
Bone: maximum moment	3.7	6.5	7.8	2.8	-2.0	2.5	-2.7	2.6
Bone: minimum diameter	5.2	9.5	11.3	3.3	-2.6	2.8	-3.4	3.3
Bone: periosteal estimation	1.9	3.8	4.5	2.1	-1.5	1.9	-2.1	2.1
Bone: periosteal perimeter	1.6	2.7	3.0	1.7	-1.5	1.5	-1.7	1.7
Bone: post-yield work	0.7	0.9	1.3	1.0	-1.2	0.7	-0.9	0.9
Bone: stiffness	1.3	2.1	2.8	1.7	-1.1	1.3	-1.6	1.5
Bone: tissue strength	4.6	4.4	5.2	2.2	-1.9	2.0	-2.3	2.1
Bone: trabecular number	0.1	0.1	0.3	0.4	-0.0	0.4	-0.5	0.2
Bone: trabecular spacing	1.6	2.0	2.5	1.6	-1.3	1.3	-1.3	1.6
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	0.3	-0.1	0.3	-0.5
Bone: trabecular tissue density	2.9	4.0	4.3	-2.0	2.1	-2.0	2.0	-1.9
Breakpoint value in progressive ratio session	1.0	1.1	1.5	1.2	-0.9	0.7	-1.2	1.2
Distance traveled before self-admin	2.1	2.2	2.6	1.5	-1.3	1.5	-1.5	1.6
Distance traveled after self-admin	5.7	6.3	6.5	2.5	-2.5	2.4	-2.5	2.5
Delta time in closed arm before/after self-admin	0.6	0.6	0.8	0.8	-0.8	0.9	-0.8	0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0	-0.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.1	0.5	-0.1	-0.1	0.3
Extinction: sum of active levers before priming	0.9	0.9	1.2	1.1	-0.8	0.7	-1.1	1.0
Active lever presses in extinction session 6	0.2	0.1	0.2	0.4	-0.3	0.3	-0.4	0.4
Delta distance traveled before/after self-admin	0.3	0.4	0.4	0.6	-0.6	0.6	-0.6	0.6
Delta ambulatory time before/after self-admin	1.2	1.3	1.5	1.2	-1.2	1.0	-1.2	1.0
Time in closed arm before self-admin	0.0	0.0	0.1	-0.2	0.3	-0.2	0.2	-0.1
Time in closed arm after self-admin	0.5	0.5	1.2	0.7	-1.1	0.6	-0.7	0.3
Time in open arm before self-admin	1.0	1.1	1.5	1.0	-0.7	1.2	-1.0	1.1
Time in open arm after self-admin	0.7	0.8	1.3	0.9	-0.5	0.9	-0.9	1.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.1	0.7	-0.5	0.1	0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	0.5	-0.7	0.6	-0.5	0.4
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	0.6	-1.0	0.7	-0.6	0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	-0.2	0.1	-0.1	0.2
Time to tail flick, test, after self-admin	0.4	0.4	1.5	0.4	-1.2	0.2	-0.4	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.4	-0.6	0.3	-0.4	0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	-0.4	0.1	-0.1	-0.0
Ambulatory time before self-admin	1.1	1.1	1.4	1.1	-0.9	1.1	-1.1	1.2
Ambulatory time after self-admin	5.5	6.0	6.7	2.5	-2.2	2.5	-2.5	2.6
Total heroin consumption	0.9	1.1	2.0	1.2	-0.7	0.6	-1.2	1.4
Area under the delay curve	0.0	0.1	0.2	-0.2	0.4	-0.2	0.2	0.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.5	-0.1	0.2	-0.5	0.5
Delay disc. indifference point, 16s delay	1.1	1.2	1.5	1.0	-1.2	1.0	-1.0	1.0
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	-0.3	0.6	-0.3	0.3	-0.3
Delay disc. indifference point, 24s delay	0.7	0.7	1.4	0.6	0.5	1.2	-0.5	1.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.2	-0.2	0.1	-0.2	0.1
Delay disc. indifference point, 8s delay	1.6	1.6	2.3	-1.2	1.5	-1.3	1.2	-1.0
Delay discount exponential model param	0.0	0.1	0.2	0.2	-0.5	0.1	-0.2	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.5	0.2	-0.2	0.1
Fecal boli incidents, locomotor time 1	2.4	2.6	4.5	-1.6	0.6	-1.6	1.6	-2.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.6	-0.7	-0.0	-0.6	0.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.2	-0.0	-0.5	-0.1	0.0	-0.1
Bouts of movement, locomotor time 1	0.3	0.3	1.0	0.5	-1.0	0.1	-0.5	0.4
Total resting periods, locomotor time 1	0.3	0.4	1.4	0.5	-1.2	0.1	-0.5	0.3
Rest time, locomotor task time 1	0.1	0.1	0.5	0.0	-0.7	-0.1	-0.0	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.2	0.6	0.3	-0.2	0.4
Vertical activity count, locomotor time 1	0.8	0.9	1.2	1.0	-0.5	1.0	-1.0	1.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.0	0.3	0.0	-0.0	0.2
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.4	-0.6	-0.3	0.4	-0.5
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.4	-0.4
Rest time, locomotor task time 2	0.4	0.5	0.7	0.6	-0.8	0.7	-0.6	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.3	0.6	-0.4	0.3	-0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	0.3	-0.0	-0.2	0.2
Weight adjusted by age	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	1.4	1.1	-0.8	1.1	-1.1	1.2
Locomotion in novel chamber	0.4	0.5	1.0	-0.6	0.4	-1.0	0.6	-0.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	0.3	0.1	0.1	-0.0
Progressive ratio	0.6	0.7	1.0	-0.8	0.6	-1.0	0.8	-0.9
Food seeking constrained by brief footshock	3.0	3.7	4.2	2.0	-1.9	1.6	-2.0	1.9
Seeking ratio, punishment vs. effort	2.5	3.0	3.4	1.8	-1.6	1.8	-1.8	1.7
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.5	0.1	-0.1	0.5	-0.6
Run reversals in cocaine runway, males	0.9	0.9	1.2	-1.0	1.1	-0.9	1.0	-0.8
Latency to leave start box in cocaine runway	0.4	0.4	1.4	-0.6	1.2	-0.2	0.6	-0.2
Latency to leave start box in cocaine runway, F	1.0	1.1	2.3	-1.0	1.5	-0.8	1.0	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	-0.5	0.4	-0.2	0.1
Cd content in liver	0.5	0.5	1.1	-0.6	0.6	-1.1	0.6	-0.6
Co content in liver	1.3	1.5	2.2	-1.1	1.0	-1.4	1.0	-1.5
Cu content in liver	1.4	1.7	2.4	1.3	-1.1	1.5	-1.3	1.3
Fe content in liver	0.5	0.6	0.7	-0.8	0.8	-0.5	0.9	-0.8
K content in liver	0.8	0.8	1.1	0.9	-0.7	1.0	-0.8	0.9
Mg content in liver	0.1	0.1	0.3	0.3	-0.3	0.6	-0.2	0.3
Mn content in liver	0.7	0.8	0.8	0.9	-0.9	0.8	-0.9	0.9
Na content in liver	5.0	5.3	6.1	2.4	-1.9	2.5	-2.3	2.4
Rb content in liver	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	0.1
Se content in liver	3.4	4.1	4.7	-2.0	2.2	-1.9	2.0	-2.0
Sr content in liver	0.4	0.3	0.6	-0.4	0.4	-0.7	0.4	-0.8
Zn content in liver	0.2	0.2	0.4	-0.4	0.6	-0.3	0.5	-0.6