Hub : Genes

Kctd21

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000024793 0.04 0.02 2.7e-04 0.02 0.01 0.01 0.01 4.4e-03 3.1e-02 2.4e-02 3.9e-02
2 Adipose mRNA stability ENSRNOG00000024793 0.19 0.09 0.0e+00 0.12 0.15 0.15 0.14 2.9e-13 4.4e-16 3.3e-16 2.3e-15
3 BLA gene expression ENSRNOG00000024793 0.22 0.1 9.1e-10 0.14 0.15 0.14 0.15 7.4e-08 1.4e-08 3.5e-08 1.9e-08
4 Brain gene expression ENSRNOG00000024793 0.13 0.07 5.9e-11 0.1 0.1 0.1 0.1 8.9e-10 2.4e-09 1.4e-09 2.5e-09
5 Brain mRNA stability ENSRNOG00000024793 0.14 0.07 6.1e-15 0.16 0.16 0.16 0.16 3.0e-14 4.3e-15 1.4e-14 8.2e-15
6 IL gene expression ENSRNOG00000024793 0.27 0.14 1.0e-03 0.07 0.09 0.05 0.07 1.0e-02 4.4e-03 2.5e-02 1.1e-02
7 OFC gene expression ENSRNOG00000024793 0.17 0.11 7.6e-03 0.04 0.07 0.04 0.06 3.1e-02 9.4e-03 4.7e-02 1.5e-02
8 PL gene expression ENSRNOG00000024793 0.21 0.11 1.8e-12 0.17 0.13 0.14 0.15 1.1e-12 4.0e-10 6.3e-11 2.5e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail1.03.45.9-1.8-1.4-2.0-1.5-1.8-2.4-1.8-1.8
BMI without tail6.413.420.5-3.5-2.0-4.1-3.4-3.3-4.5-4.1-3.9
Body weight2.811.920.3-3.6-2.0-3.9-3.1-2.8-4.5-3.3-3.7
Epididymis fat weight2.96.710.9-2.7-1.0-2.7-2.5-2.3-2.7-3.3-2.9
Glucose0.20.30.9-0.10.60.30.20.90.30.9-0.1
Heart weight0.40.51.6-0.31.3-0.2-0.71.20.20.6-0.4
Left kidney weight1.54.36.9-2.60.4-2.5-2.3-0.5-2.3-1.7-2.6
Right kidney weight1.13.14.7-2.0-0.1-2.2-2.0-0.9-2.1-1.7-2.0
Tail length4.413.319.9-4.2-0.3-4.4-4.0-1.8-4.2-3.5-4.5
Length with tail2.69.615.1-3.4-1.2-3.6-3.1-2.1-3.9-2.9-3.5
Length without tail0.10.30.80.4-0.90.30.5-0.3-0.10.60.6
Liver weight, left0.81.32.2-1.3-0.9-1.2-0.9-1.1-1.5-1.1-1.2
Liver weight, right3.66.010.5-2.1-2.4-2.2-1.5-3.2-2.7-3.2-1.9
Parametrial fat weight1.32.44.3-0.9-2.0-1.4-1.0-2.1-2.0-1.7-0.8
Retroperitoneal fat weight6.019.829.6-4.3-3.0-4.7-3.9-4.5-5.4-5.1-4.1
Intraocular pressure2.63.68.90.72.41.40.73.01.92.80.7
Extensor digitorum longus weight0.41.62.9-1.5-0.2-1.6-1.3-0.3-1.7-0.5-1.7
Soleus weight1.23.55.7-2.1-0.9-2.2-2.0-1.3-2.4-1.8-1.8
Tibialis anterior weight0.30.91.6-0.8-0.7-1.0-0.8-0.7-1.3-0.7-1.2
Tibia length0.41.12.50.51.40.80.61.61.31.20.5
Number of licking bursts1.01.23.80.2-1.9-0.30.1-1.9-0.9-1.10.1
Food consumed during 24 hour testing period1.01.22.00.51.41.00.81.41.31.40.4
Times rat made contact with spout0.70.81.7-0.6-0.9-0.7-0.5-1.3-1.0-1.1-0.7
Mean time between licks in bursts2.53.56.6-2.61.7-1.9-2.40.6-1.2-1.2-2.5
Mean num. licks in bursts0.70.82.9-0.51.70.0-0.31.50.50.8-0.5
Std. dev. time between licks in bursts2.42.84.6-1.8-0.2-1.9-2.1-1.0-1.8-1.9-1.7
Water consumed over 24 hours0.50.51.40.6-1.20.30.7-1.2-0.2-0.40.5
Indifference point 0 sec0.50.91.3-1.11.1-0.8-1.01.1-0.60.6-0.8
Indifference point AUC0.20.20.8-0.40.4-0.5-0.90.2-0.3-0.2-0.4
Indifference point function ln k0.50.81.60.70.20.81.30.70.71.30.8
Indifference point function log k0.50.81.60.70.20.81.30.70.71.30.8
Delay discounting total patch changes 0 sec0.50.71.4-1.01.1-0.6-0.91.2-0.40.8-0.7
Delay discounting total patch changes 12 sec0.70.91.8-1.31.0-0.9-1.30.4-0.5-0.7-1.1
Delay discounting total patch changes 18 sec0.91.22.4-1.31.3-1.2-1.50.9-0.7-0.2-1.3
Delay discounting total patch changes 24 sec0.81.12.5-1.21.1-1.0-1.60.4-0.5-0.7-1.1
Delay discounting total patch changes 6 sec0.10.10.4-0.1-0.2-0.00.00.2-0.30.60.3
Delay discounting time to switch 0 sec1.01.63.81.1-1.90.61.2-2.00.2-1.10.8
Delay discounting water rate 0 sec0.81.23.5-0.61.8-0.2-0.81.90.31.1-0.7
Delay discounting water rate 12 sec0.50.82.40.11.10.1-0.31.50.21.5-0.1
Delay discounting water rate 18 sec0.40.51.0-0.61.0-0.6-0.80.9-0.50.6-0.6
Delay discounting water rate 24 sec0.91.33.80.71.00.90.71.50.92.00.6
Delay discounting water rate 6 sec0.50.82.00.60.70.80.51.20.81.40.8
Locomotor activity0.50.71.7-0.6-0.8-1.0-0.6-1.0-1.3-0.8-0.3
Locomotor testing distance1.22.03.7-1.70.3-1.9-1.7-0.2-1.7-1.0-1.4
Locomotor testing rearing2.74.36.7-2.3-0.5-2.6-2.0-1.3-2.5-2.2-2.2
Light reinforcement 10.61.23.3-0.1-1.5-0.6-0.3-1.8-0.9-1.6-0.2
Light reinforcement 20.10.20.40.4-0.40.40.3-0.40.3-0.30.6
Reaction time number correct0.60.91.91.4-1.00.81.3-0.50.50.51.2
Reaction time mean minus median0.40.51.1-1.00.1-1.0-0.90.1-1.0-0.2-0.7
Reaction time mean minus median AUC0.10.10.3-0.50.1-0.4-0.40.2-0.50.2-0.2
Reaction time num false alarms0.30.51.0-0.3-0.8-0.5-0.6-1.0-0.7-0.8-0.3
Reaction time num false alarms AUC0.00.00.1-0.0-0.20.0-0.2-0.3-0.0-0.30.1
Reaction time trials correct on left0.60.91.91.4-1.00.81.3-0.50.50.51.2
Reaction time trials on left0.60.91.91.4-1.00.81.3-0.50.50.41.2
Reaction time mean0.20.30.7-0.3-0.6-0.6-0.4-0.8-0.6-0.8-0.2
Reaction time mean AUC0.10.10.4-0.1-0.6-0.2-0.2-0.6-0.3-0.50.1
Median of all reaction times0.10.20.50.2-0.5-0.10.0-0.7-0.1-0.70.2
Reaction time omissions0.40.50.9-0.80.0-0.9-1.0-0.0-0.8-0.4-0.8
Reaction time false alarm rate0.10.20.5-0.60.2-0.2-0.7-0.1-0.1-0.4-0.3
Reaction time premature initiation rate3.54.77.0-2.6-0.1-2.6-2.2-1.1-2.5-2.2-2.5
Reaction time premature initiations1.62.33.4-1.7-0.4-1.8-1.3-1.0-1.8-1.7-1.6
Std. dev. reaction times0.91.32.3-1.4-0.0-1.5-1.3-0.3-1.4-0.9-1.1
Reaction time trials completed0.60.91.91.4-1.00.81.3-0.50.50.41.2
Reaction time trials AUC0.40.61.31.2-1.00.61.0-0.60.20.31.0
Social response proportion1.01.13.3-0.2-1.4-0.40.0-1.8-0.7-1.60.0
Social responses1.82.33.7-1.2-1.4-1.5-1.1-1.9-1.9-1.8-1.0
Social time0.70.92.60.7-1.60.10.2-1.6-0.3-1.10.6
Conditioned locomotion0.20.30.60.7-0.30.50.60.10.30.80.6
Cocaine response after cond. corrected0.10.20.4-0.40.5-0.3-0.70.2-0.0-0.3-0.3
Cocaine response after cond. not corrected0.10.10.30.10.50.3-0.00.40.6-0.00.2
Cocaine response before conditioning0.70.91.51.1-0.41.11.2-0.21.10.21.2
Saline control response0.81.01.8-1.20.2-1.3-1.30.2-1.4-0.1-1.1
Condit. Reinf. active minus inactive responses2.22.74.6-2.12.0-1.7-1.91.7-1.00.1-1.8
Condit. Reinf. active-inactive response ratio0.91.02.2-1.01.5-0.6-0.91.5-0.20.6-0.8
Condit. Reinf. active responses3.34.57.8-2.82.1-2.4-2.61.6-1.6-0.2-2.5
Condit. Reinf. inactive responses2.22.74.3-2.00.5-2.0-2.1-0.0-1.8-1.0-2.1
Condit. Reinf. lever presses2.94.011.7-1.53.1-0.9-1.33.4-0.12.2-1.3
Condit. Reinf. lever reinforcers received3.24.47.4-2.72.4-2.2-2.61.9-1.40.0-2.4
Pavlov. Cond. lever latency3.95.316.81.3-3.60.71.4-4.1-0.3-2.81.0
Pavlov. Cond. magazine entry latency2.42.78.40.22.20.6-0.12.91.12.50.5
Pavlov. Cond. change in total contacts2.33.210.0-1.12.9-0.6-1.03.20.12.0-0.9
Pavlov. Cond. index score3.54.514.9-1.03.4-0.3-1.13.90.62.7-0.6
Pavlov. Cond. latency score3.34.214.1-0.73.2-0.1-0.93.80.72.7-0.3
Pavlov. Cond. lever contacts3.54.814.5-1.43.4-0.8-1.53.80.02.6-1.1
Pavlov. Cond. magazine entry number4.55.517.90.4-3.7-0.50.6-4.2-1.4-3.10.0
Pavlov. Cond. intertrial magazine entries3.03.97.2-1.7-1.1-2.1-1.9-2.0-2.2-2.7-1.7
Pavlov. Cond. lever-magazine prob. diff.3.34.213.7-1.03.3-0.4-1.23.70.52.5-0.7
Pavlov. Cond. response bias4.15.717.9-1.33.9-0.6-1.54.20.42.7-1.0
Conditioned reinforcement - actives2.42.44.80.62.21.40.82.12.21.30.6
Conditioned reinforcement - inactives0.10.10.30.20.10.50.3-0.00.5-0.00.3
Conditioned locomotion2.12.55.20.81.91.70.92.02.31.50.9
Intermittent access intake day 1-15 change1.31.32.70.51.41.00.61.71.31.50.5
Intermittent access intake escalation1.41.33.20.41.60.80.51.81.21.50.3
Intermittent access intake escalation 20.20.20.8-0.30.90.1-0.20.60.50.1-0.3
Intermitt. access day 1 inactive lever presses0.20.20.90.1-0.30.2-0.1-0.80.3-0.90.2
Intermitt. access day 15 inactive lever presses0.10.10.10.3-0.00.30.20.00.30.20.3
Intermitt. access escalation Index0.20.20.50.4-0.70.40.5-0.50.00.10.4
Intermittent access day 1 total infusions0.40.51.5-0.61.2-0.1-0.51.10.30.5-0.5
Intermittent access day 15 total infusions1.82.05.00.22.11.00.32.21.51.70.2
Intermittent access terminal intake (last 3 days)0.80.92.7-0.31.70.5-0.11.51.00.8-0.2
Intermittent access total infusions0.60.72.5-0.41.60.4-0.21.30.90.5-0.3
Intermittent access day 1 locomotion0.60.71.80.50.71.10.60.71.30.60.6
Intermittent access day 15 total locomotion0.60.72.0-0.21.40.4-0.11.40.80.7-0.2
Intermittent access total locomotion0.30.31.2-0.31.10.3-0.10.90.70.3-0.3
Intermittent access standard deviation0.10.10.2-0.30.4-0.0-0.40.00.2-0.4-0.4
Cocaine induced anxiety0.50.62.00.4-1.40.10.7-1.2-0.4-0.40.7
Post-drug Anxiety0.10.10.2-0.1-0.4-0.30.1-0.3-0.4-0.10.2
Baseline Anxiety0.90.92.9-0.31.7-0.1-0.51.70.41.0-0.4
Lifetime Intake0.70.83.0-0.31.70.4-0.11.41.00.6-0.2
Incentive Sensitization - Responses1.61.63.4-1.51.8-0.8-1.51.3-0.2-0.1-1.7
Incentive Sensitization - Breakpoint1.41.43.3-1.41.8-0.7-1.31.2-0.1-0.0-1.6
Progressive ratio test 1 active lever presses0.20.20.40.4-0.00.60.6-0.00.60.10.5
Progressive ratio test 1 breakpoint0.20.20.40.5-0.10.60.6-0.10.70.00.6
Progressive ratio test 1 inactive lever presses0.00.00.1-0.00.30.0-0.20.20.2-0.2-0.1
Progressive ratio test 2 active lever presses1.11.23.6-1.21.9-0.5-1.11.30.20.0-1.3
Progressive ratio test 2 breakpoint0.91.02.7-1.11.6-0.5-1.01.00.1-0.1-1.3
Progressive ratio test 2 inactive lever presses0.40.41.6-0.51.3-0.1-0.40.90.30.1-0.6
Total sessions with >9 infusions0.60.61.80.11.30.60.31.11.10.50.4
Short access day 1 total inactive lever presses0.20.20.50.00.70.20.00.70.40.40.1
Short access day 10 total inactive lever presses0.50.62.00.1-1.4-0.10.0-1.3-0.6-0.70.1
Short access day 1 total infusions0.50.62.5-0.51.6-0.1-0.31.10.50.0-0.4
Short access day 10 total infusions0.60.72.7-0.71.6-0.1-0.41.20.50.1-0.5
Short access total infusions0.40.41.7-0.41.30.0-0.20.90.6-0.1-0.2
Short access day 1 locomotion2.02.13.60.91.71.30.91.91.81.61.0
Short access day 10 total locomotion0.00.10.2-0.30.4-0.0-0.10.30.2-0.0-0.2
Short access total locomotion0.30.30.80.30.40.70.50.10.9-0.20.6
Compulsive drug intake0.00.00.10.00.10.10.1-0.10.2-0.30.1
One hour access (0.3 mA shock)1.11.34.0-1.32.0-0.6-1.11.30.10.0-1.0
One hour access (shock baseline)0.50.62.0-0.71.4-0.1-0.51.20.30.5-0.4
Number of responses in last shaping day1.61.64.0-1.30.4-1.3-1.5-0.7-0.8-2.0-1.4
Context. condit. distance diff. score1.92.35.90.32.31.00.52.41.71.70.5
Locomotion velocity, session 11.51.62.31.20.91.31.11.21.51.31.4
Locomotion distance, session 10.40.50.90.50.90.60.21.00.90.70.6
Locomotion velocity, session 20.30.31.1-0.21.10.0-0.10.90.30.5-0.1
Locomotion distance, session 20.00.00.1-0.1-0.2-0.3-0.1-0.1-0.40.10.0
Locomotion velocity, session 30.20.20.50.20.60.30.10.70.50.60.3
Locomotion distance, session 31.51.73.70.71.61.10.41.91.51.60.6
Stereotopy head waving bouts, day 31.41.75.2-0.2-1.8-0.5-0.2-2.3-0.9-1.90.0
Stereotopy head waving duration, day 30.20.20.70.4-0.80.20.4-0.6-0.20.20.6
Locomotion velocity, session 70.20.30.60.20.60.40.40.80.60.70.2
Locomotion distance, session 70.40.51.3-0.61.1-0.2-0.51.10.20.4-0.6
Stereotopy head waving bouts, day 70.40.40.80.60.40.80.80.30.90.30.7
Stereotopy head waving duration, day 70.10.10.30.10.60.30.30.50.40.40.2
Locomotion velocity, session 83.94.711.40.62.71.51.13.42.13.11.0
Locomotion distance, session 80.81.13.10.11.60.60.41.81.01.40.3
Degree of sensitization distance2.12.13.0-1.7-0.4-1.7-1.4-1.0-1.7-1.7-1.5
Degree of sensitization stereotypy1.71.83.00.81.71.31.01.71.71.40.7
Condit. Reinf. active minus inactive responses1.61.72.7-1.6-0.3-1.6-1.6-0.6-1.6-1.1-1.3
Condit. Reinf. active-inactive response ratio1.61.72.7-1.5-0.4-1.6-1.6-0.7-1.6-1.1-1.3
Condit. Reinf. active responses0.91.11.7-1.1-0.6-1.2-1.1-0.7-1.3-1.0-0.9
Condit. Reinf. inactive responses0.00.00.0-0.1-0.1-0.00.1-0.2-0.1-0.1-0.0
Incentive salience index mean0.91.11.9-1.40.3-1.3-1.40.0-1.0-0.7-1.1
Condit. Reinf. lever presses0.20.30.9-0.31.0-0.0-0.20.90.30.5-0.1
Time in familiar zone, hab. session 10.00.00.1-0.00.20.10.10.20.20.1-0.1
Time in novel zone, hab. session 10.60.61.2-0.6-0.7-0.9-0.7-0.7-1.1-0.7-0.5
Total zone transitions, hab. session 10.91.32.81.3-1.01.01.5-0.20.61.01.7
Total locomotion distance, hab. session 13.65.111.6-1.1-2.6-1.7-1.2-3.4-2.2-3.4-0.9
Locomotion velocity, hab. session 12.94.210.2-0.9-2.4-1.4-1.1-3.2-1.9-3.2-0.8
Time in familiar zone, hab. session 20.30.40.7-0.80.7-0.6-0.70.5-0.50.3-0.6
Time in novel zone, hab. session 20.10.10.20.10.30.20.00.30.4-0.1-0.0
Total zone transitions, hab. session 20.40.51.20.9-0.60.60.70.20.31.01.1
Total locomotion distance, hab. session 23.04.07.6-1.3-2.0-1.8-1.6-2.6-2.2-2.7-1.1
Locomotion velocity, hab. session 23.44.68.0-1.4-2.2-2.0-1.7-2.8-2.4-2.8-1.2
Novel to familiar place preference ratio0.10.10.30.1-0.50.10.5-0.3-0.0-0.0-0.2
Novelty place preference0.00.00.10.0-0.2-0.00.4-0.1-0.10.0-0.3
Time in novel zone, NPP test0.00.00.1-0.0-0.00.00.40.2-0.00.3-0.3
Total zone transitions, NPP test0.71.12.01.10.31.00.90.91.01.41.3
Total locomotion distance, NPP test1.92.67.4-1.1-1.2-1.4-1.4-2.0-1.4-2.7-1.0
Locomotion velocity, NPP test2.23.19.0-1.1-1.5-1.4-1.4-2.4-1.5-3.0-0.9
Pavlov. Cond. lever latency0.30.41.40.5-1.20.10.3-1.0-0.2-0.30.4
Pavlov. Cond. magazine entry latency0.60.81.6-1.31.1-0.9-0.90.9-0.5-0.0-1.0
Pavlov. Cond. change in total contacts0.60.72.4-0.81.6-0.2-0.61.20.50.0-0.6
Pavlov. Cond. index score0.91.12.2-1.41.5-1.0-1.11.1-0.4-0.1-1.1
Pavlov. Cond. latency score0.70.92.0-1.31.4-0.8-0.91.1-0.3-0.1-1.1
Pavlov. Cond. lever contacts0.50.61.5-1.01.2-0.6-0.80.9-0.1-0.0-0.8
Pavlov. Cond. magazine entry number0.70.91.61.2-1.30.90.9-1.20.4-0.30.9
Pavlov. Cond. intertrial magazine entries0.30.31.10.1-0.8-0.0-0.1-1.1-0.2-0.90.1
Pavlov. Cond. lever-magazine prob. diff.0.70.82.0-1.21.4-0.7-0.91.1-0.20.0-0.9
Pavlov. Cond. response bias0.40.50.9-1.00.8-0.8-0.80.6-0.4-0.2-0.7
Bone: apparent density0.20.30.50.5-0.10.70.70.10.50.50.5
Bone surface0.50.93.0-0.51.70.1-0.21.60.60.9-0.6
Bone volume0.30.61.7-0.71.3-0.3-0.41.10.10.5-0.8
Bone: connectivity density0.91.52.81.10.81.41.11.11.71.21.1
Bone: cortical apparent density0.20.20.5-0.1-0.7-0.4-0.2-0.7-0.6-0.3-0.1
Bone: cortical area0.71.02.3-1.40.7-1.1-1.00.5-0.8-0.4-1.5
Bone: cortical porosity0.20.30.50.6-0.10.60.70.00.60.20.6
Bone: cortical porosity0.30.30.50.7-0.10.70.7-0.10.7-0.00.6
Bone: cortical thickness0.10.10.2-0.4-0.3-0.3-0.2-0.3-0.3-0.4-0.4
Bone: cortical thickness0.50.61.9-0.21.40.2-0.41.30.80.40.0
Bone: cortical tissue density0.10.20.5-0.0-0.7-0.3-0.1-0.7-0.6-0.3-0.0
Bone: elastic displacement0.30.30.70.8-0.60.70.7-0.20.40.40.5
Bone: elastic work1.31.72.91.7-0.41.61.60.31.31.31.4
Bone: endosteal estimation0.92.03.5-1.91.5-1.5-1.60.9-0.9-0.5-1.8
Bone: endosteal perimeter1.02.14.7-1.72.2-1.1-1.31.7-0.50.5-1.6
Bone: final force0.20.30.60.20.50.50.60.70.60.70.3
Bone: final moment0.10.20.50.00.50.30.50.70.50.70.1
Bone: marrow area0.81.83.2-1.81.3-1.4-1.60.7-0.9-0.5-1.7
Bone: maximum diameter0.81.52.6-1.61.6-1.0-1.11.3-0.60.3-1.6
Bone: maximum force0.40.81.70.30.80.80.81.20.91.30.4
Bone: maximum moment0.40.71.50.20.80.70.71.20.81.20.2
Bone: minimum diameter1.42.64.8-2.20.7-2.0-1.9-0.0-1.6-1.2-2.1
Bone: periosteal estimation1.12.34.1-2.01.8-1.4-1.51.3-0.8-0.2-2.0
Bone: periosteal perimeter0.81.42.5-1.51.1-1.2-1.20.9-1.00.3-1.6
Bone: post-yield work0.20.30.50.40.10.60.70.30.60.60.6
Bone: stiffness0.10.20.50.2-0.10.40.70.20.30.50.5
Bone: tissue strength2.52.45.01.8-1.21.92.2-0.51.40.81.8
Bone: trabecular number0.60.91.61.1-0.31.21.30.01.00.81.3
Bone: trabecular spacing0.20.20.8-0.10.9-0.1-0.50.60.3-0.0-0.2
Bone: trabecular thickness0.40.51.4-0.8-0.5-0.9-0.7-0.3-1.20.0-0.7
Bone: trabecular tissue density1.92.64.7-0.9-2.1-1.5-0.9-2.1-2.2-1.6-0.9
Breakpoint value in progressive ratio session0.30.30.60.60.30.70.50.50.80.60.6
Distance traveled before self-admin0.00.00.1-0.0-0.3-0.1-0.1-0.3-0.2-0.20.0
Distance traveled after self-admin0.70.81.71.1-1.30.80.9-0.90.30.11.1
Delta time in closed arm before/after self-admin1.21.23.1-1.2-0.2-1.6-1.20.0-1.80.1-1.1
Delta time in open arm before/after self-admin0.60.61.5-0.81.2-0.3-0.90.80.1-0.1-0.9
Diff in mean of infusions in LGA sessions0.91.03.70.3-1.9-0.10.5-1.7-0.8-0.70.4
Extinction: sum of active levers before priming0.30.30.5-0.70.3-0.6-0.60.2-0.6-0.1-0.7
Active lever presses in extinction session 60.50.51.20.80.70.80.40.71.10.50.5
Delta distance traveled before/after self-admin0.30.41.00.8-1.00.40.6-0.60.00.20.6
Delta ambulatory time before/after self-admin0.70.81.71.3-0.90.91.0-0.20.40.91.0
Time in closed arm before self-admin1.11.31.81.40.21.31.20.61.41.11.2
Time in closed arm after self-admin2.12.23.61.60.41.61.61.11.51.91.6
Time in open arm before self-admin0.50.61.5-0.1-1.2-0.5-0.1-1.2-0.8-0.90.0
Time in open arm after self-admin1.11.21.7-1.3-0.2-1.2-1.3-0.7-1.2-1.3-1.2
Sum of active levers in priming session hrs 5-60.30.30.6-0.1-0.7-0.4-0.3-0.7-0.6-0.5-0.5
Time to tail flick, vehicle, before self-admin0.40.40.8-0.2-0.8-0.6-0.3-0.9-0.9-0.7-0.4
Time to tail flick, vehicle, after self-admin0.70.82.20.51.10.40.21.50.71.40.1
Time to tail flick, test, before self-admin0.30.30.7-0.40.8-0.2-0.30.90.10.5-0.3
Time to tail flick, test, after self-admin0.70.71.1-0.91.0-1.0-1.00.8-0.6-0.0-1.1
Delta time to tail flick, vehicle, before/after SA2.12.04.20.91.61.20.72.01.61.90.7
Delta time to tail flick, test, before/after SA0.10.10.20.3-0.4-0.10.1-0.4-0.2-0.30.0
Ambulatory time before self-admin0.20.20.30.40.10.50.40.30.50.50.4
Ambulatory time after self-admin1.21.32.51.6-1.11.31.2-0.30.80.91.4
Total heroin consumption0.00.10.20.3-0.00.20.10.20.10.50.1
Area under the delay curve0.40.41.20.30.80.40.21.10.51.10.2
Delay disc. indifference point, 0s delay0.30.30.7-0.70.8-0.4-0.80.40.0-0.3-0.7
Delay disc. indifference point, 16s delay0.80.82.41.10.20.70.80.90.61.50.8
Delay disc. indifference point, 2s delay0.30.30.9-0.21.00.3-0.20.90.50.6-0.2
Delay disc. indifference point, 24s delay0.30.30.80.5-0.20.30.70.30.10.90.5
Delay disc. indifference point, 4s delay0.70.71.3-1.01.1-0.6-1.01.0-0.20.4-1.0
Delay disc. indifference point, 8s delay0.60.61.70.30.90.50.31.30.61.30.4
Delay discount exponential model param0.40.51.3-0.4-0.7-0.4-0.3-1.0-0.5-1.2-0.3
Delay discount hyperbolic model param0.40.41.3-0.1-0.9-0.3-0.0-1.1-0.5-1.0-0.1
Fecal boli incidents, locomotor time 11.71.84.90.52.20.8-0.12.11.71.10.2
Change in fecal boli incidents, locomotor task1.00.93.40.6-1.80.00.9-1.4-0.7-0.30.7
Time >=10cm from walls, locomotor time 11.01.01.70.90.81.00.71.31.21.30.6
Bouts of movement, locomotor time 10.20.20.90.00.3-0.1-0.10.7-0.21.0-0.0
Total resting periods, locomotor time 10.40.41.80.50.20.50.40.80.31.30.5
Rest time, locomotor task time 10.70.81.80.80.40.80.81.00.81.40.9
Distance moved, locomotor task time 11.31.52.6-1.40.3-1.4-1.4-0.4-1.2-1.3-1.6
Vertical activity count, locomotor time 10.80.91.7-1.00.2-1.0-1.3-0.3-0.9-0.8-1.3
Time >=10cm from walls, locomotor time 20.40.41.0-0.61.0-0.3-0.70.90.10.1-0.9
Bouts of movement, locomotor time 20.20.20.4-0.60.0-0.5-0.5-0.0-0.5-0.2-0.6
Total resting periods, locomotor time 20.10.10.1-0.40.0-0.3-0.30.0-0.3-0.1-0.3
Rest time, locomotor task time 20.80.91.71.2-1.00.81.3-0.90.5-0.31.3
Distance moved, locomotor task time 21.72.03.9-1.81.6-1.2-1.81.0-0.6-0.5-2.0
Vertical activity count, locomotor time 21.81.93.9-1.71.1-1.4-2.00.5-0.9-0.8-2.0
Weight adjusted by age1.51.63.2-1.80.7-1.4-1.6-0.0-1.1-1.1-1.6
Seeking ratio, delayed vs. immediate footshock0.10.10.20.20.10.30.3-0.00.5-0.20.2
Locomotion in novel chamber1.51.93.30.80.91.61.21.31.81.51.4
Locomotion in novel chamber post-restriction3.03.57.01.01.81.81.22.52.12.61.2
Progressive ratio1.11.32.60.91.00.90.81.51.11.60.9
Food seeking constrained by brief footshock1.01.22.5-1.30.2-1.6-1.0-0.1-1.4-0.8-1.3
Seeking ratio, punishment vs. effort2.63.25.8-1.8-0.6-1.9-1.7-1.5-1.9-2.4-2.0
Run reversals in cocaine runway, females4.04.06.3-2.3-0.2-2.5-2.3-0.8-2.5-1.6-2.4
Run reversals in cocaine runway, males1.11.13.30.70.90.80.51.50.91.80.5
Latency to leave start box in cocaine runway0.60.62.00.1-1.0-0.20.1-1.4-0.3-1.40.1
Latency to leave start box in cocaine runway, F0.70.83.1-0.6-0.4-0.7-0.6-1.1-0.5-1.8-0.5
Latency to leave start box in cocaine runway, M0.90.81.61.2-0.91.01.2-0.70.70.11.1
Cd content in liver0.30.40.7-0.5-0.4-0.6-0.5-0.7-0.7-0.8-0.4
Co content in liver1.01.12.0-1.41.2-1.1-1.40.8-0.6-0.3-1.1
Cu content in liver1.82.13.9-1.70.4-1.8-2.0-0.1-1.6-1.0-1.8
Fe content in liver0.30.31.1-0.41.1-0.0-0.30.80.4-0.0-0.5
K content in liver0.40.41.2-0.0-0.9-0.20.0-1.1-0.5-0.8-0.1
Mg content in liver0.00.00.1-0.20.1-0.2-0.20.0-0.2-0.1-0.3
Mn content in liver1.11.32.31.5-0.61.41.5-0.41.10.41.3
Na content in liver0.60.61.41.0-0.11.10.9-0.21.2-0.10.7
Rb content in liver0.40.50.9-0.90.4-0.9-0.80.5-0.90.4-0.8
Se content in liver0.81.01.81.2-1.00.91.0-1.30.6-0.71.1
Sr content in liver0.50.51.00.40.90.60.41.00.80.90.3
Zn content in liver1.01.02.1-1.21.3-1.0-1.40.9-0.6-0.1-1.0