Hub : Genes

Slx4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000024445 0.47 0.11 0.0e+00 0.38 0.38 0.39 0.38 7.1e-45 5.3e-44 9.3e-46 4.5e-45
2 Adipose mRNA stability ENSRNOG00000024445 0.36 0.09 0.0e+00 0.36 0.37 0.36 0.37 2.0e-41 2.3e-43 2.3e-42 2.4e-43
3 BLA gene expression ENSRNOG00000024445 0.41 0.11 0.0e+00 0.32 0.3 0.32 0.33 6.0e-18 2.3e-16 1.4e-17 3.7e-18
4 BLA mRNA stability ENSRNOG00000024445 0.11 0.05 5.4e-07 0.12 0.12 0.06 0.11 4.3e-07 7.3e-07 4.6e-04 2.1e-06
5 Brain gene expression ENSRNOG00000024445 0.71 0.04 0.0e+00 0.56 0.6 0.6 0.62 2.4e-62 4.8e-69 8.1e-70 2.1e-72
6 Brain mRNA stability ENSRNOG00000024445 0.12 0.04 0.0e+00 0.19 0.2 0.2 0.2 2.7e-17 4.7e-18 1.3e-18 2.5e-18
7 IL gene expression ENSRNOG00000024445 0.64 0.11 3.0e-10 0.29 0.27 0.32 0.32 1.2e-07 2.8e-07 1.6e-08 1.6e-08
8 IL mRNA stability ENSRNOG00000024445 0.33 0.15 4.9e-04 0.14 0.05 0.07 0.07 4.1e-04 2.1e-02 8.1e-03 1.1e-02
9 LHb gene expression ENSRNOG00000024445 0.54 0.12 2.2e-06 0.3 0.21 0.27 0.26 7.8e-08 1.0e-05 4.7e-07 5.7e-07
10 LHb mRNA stability ENSRNOG00000024445 0.33 0.12 2.3e-04 0.17 0.06 0.05 0.09 6.3e-05 1.4e-02 2.1e-02 4.3e-03
11 Liver gene expression ENSRNOG00000024445 0.51 0.12 0.0e+00 0.32 0.3 0.31 0.32 2.8e-36 2.4e-34 1.3e-34 4.0e-36
12 NAcc gene expression ENSRNOG00000024445 0.29 0.08 0.0e+00 0.29 0.25 0.27 0.28 4.4e-22 1.1e-18 1.9e-20 8.0e-21
13 NAcc mRNA stability ENSRNOG00000024445 0.2 0.07 3.1e-15 0.2 0.19 0.2 0.19 3.4e-15 3.6e-14 1.8e-14 3.8e-14
14 OFC gene expression ENSRNOG00000024445 0.46 0.15 8.4e-06 0.18 0.14 0.2 0.15 4.6e-05 2.8e-04 1.9e-05 1.8e-04
15 PL gene expression ENSRNOG00000024445 0.44 0.08 0.0e+00 0.5 0.48 0.5 0.51 1.0e-43 7.0e-41 3.9e-43 3.2e-44
16 PL mRNA stability ENSRNOG00000024445 0.18 0.08 6.9e-12 0.15 0.15 0.12 0.15 1.9e-11 1.2e-11 2.5e-09 1.7e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
BMI with tail0.30.83.4-0.5-0.8-0.7-1.8-0.4-1.6-0.3-0.70.7-0.8-0.8-0.7-0.70.0-0.7-1.3
BMI without tail0.20.51.60.80.50.4-1.00.8-0.40.70.31.30.50.60.60.61.10.50.1
Body weight1.66.98.72.92.82.70.92.81.92.82.72.42.72.72.82.83.02.82.5
Epididymis fat weight1.63.75.41.81.92.11.81.82.01.71.90.82.02.02.02.02.12.02.3
Glucose1.01.52.8-1.0-1.0-1.5-1.4-1.0-1.6-0.9-1.1-0.3-1.2-1.3-1.2-1.2-1.7-1.2-1.2
Heart weight0.40.61.40.81.20.70.90.60.90.60.80.00.80.70.70.70.50.71.0
Left kidney weight2.15.98.32.52.82.52.32.22.92.22.50.72.62.62.62.62.22.52.7
Right kidney weight1.54.47.32.12.42.22.41.82.71.82.20.32.22.22.22.21.62.22.4
Tail length3.29.711.73.43.43.21.93.22.93.13.22.03.43.43.43.42.93.33.4
Length with tail5.420.027.44.55.04.63.94.34.84.34.82.04.74.74.74.74.04.75.2
Length without tail2.35.06.42.12.32.51.92.12.42.22.51.12.32.32.22.22.22.42.5
Liver weight, left0.40.71.90.70.80.81.40.41.40.60.8-0.40.70.70.70.70.50.80.9
Liver weight, right0.10.20.8-0.1-0.5-0.2-0.9-0.0-0.70.1-0.10.6-0.2-0.2-0.2-0.20.4-0.2-0.8
Parametrial fat weight0.30.72.70.61.00.71.60.41.40.30.6-0.60.70.70.80.8-0.00.60.9
Retroperitoneal fat weight3.110.413.93.13.73.53.22.93.72.93.31.03.33.33.33.32.93.33.7
Intraocular pressure0.40.61.4-0.8-0.3-0.9-0.0-0.9-0.4-0.8-0.7-0.8-0.9-0.9-0.8-0.8-1.2-0.7-0.3
Extensor digitorum longus weight0.51.97.21.60.21.3-1.51.8-0.51.71.02.71.31.31.41.41.31.2-0.1
Soleus weight3.49.914.83.62.43.3-0.13.81.33.63.03.83.43.43.43.43.53.32.3
Tibialis anterior weight0.92.97.22.00.81.8-0.92.20.12.11.52.71.81.81.81.81.81.70.7
Tibia length0.00.10.7-0.20.00.10.8-0.30.7-0.20.0-0.9-0.1-0.0-0.0-0.00.3-0.00.2
Number of licking bursts0.10.11.2-0.10.3-0.01.1-0.10.5-0.1-0.1-0.50.00.00.00.0-0.20.00.3
Food consumed during 24 hour testing period8.610.412.4-3.5-3.4-3.4-1.5-3.5-2.3-3.4-3.4-2.7-3.4-3.4-3.4-3.4-3.5-3.4-3.3
Times rat made contact with spout2.52.86.4-1.8-1.7-1.60.8-2.0-0.2-2.0-1.6-2.5-1.6-1.6-1.6-1.6-2.1-1.6-1.3
Mean time between licks in bursts0.20.31.2-0.20.4-0.30.7-0.50.4-0.6-0.3-1.1-0.2-0.2-0.2-0.2-1.1-0.20.2
Mean num. licks in bursts0.30.30.9-0.5-0.8-0.4-0.0-0.70.1-0.7-0.4-1.0-0.5-0.5-0.5-0.5-0.6-0.5-0.5
Std. dev. time between licks in bursts0.40.40.8-0.6-0.1-0.9-0.1-0.7-0.6-0.8-0.8-0.4-0.7-0.7-0.8-0.8-0.8-0.7-0.7
Water consumed over 24 hours1.72.03.0-1.7-1.6-1.40.5-1.7-0.5-1.7-1.5-1.7-1.5-1.5-1.4-1.4-1.3-1.5-1.2
Indifference point 0 sec0.00.00.3-0.1-0.10.00.5-0.00.20.00.1-0.20.10.10.00.00.40.10.2
Indifference point AUC0.10.20.90.10.60.21.00.10.50.20.5-0.10.20.20.10.10.30.30.7
Indifference point function ln k0.20.21.1-0.3-0.8-0.3-1.0-0.2-0.7-0.2-0.50.2-0.4-0.4-0.3-0.3-0.0-0.3-0.8
Indifference point function log k0.20.21.1-0.3-0.8-0.3-1.0-0.2-0.7-0.2-0.50.2-0.4-0.4-0.3-0.3-0.0-0.3-0.8
Delay discounting total patch changes 0 sec0.00.10.4-0.00.10.10.60.10.30.00.2-0.10.10.10.10.10.40.20.2
Delay discounting total patch changes 12 sec0.10.10.70.00.20.10.80.10.20.20.3-0.00.10.10.10.10.60.20.4
Delay discounting total patch changes 18 sec0.10.11.1-0.30.0-0.11.0-0.30.3-0.30.1-0.5-0.1-0.1-0.2-0.20.0-0.00.3
Delay discounting total patch changes 24 sec1.62.04.51.31.41.51.11.41.11.41.51.11.41.41.41.42.11.51.3
Delay discounting total patch changes 6 sec0.10.10.2-0.4-0.4-0.20.2-0.2-0.4-0.2-0.10.0-0.3-0.3-0.3-0.30.3-0.2-0.4
Delay discounting time to switch 0 sec0.00.10.40.40.30.10.10.20.10.20.20.10.30.30.20.2-0.60.20.2
Delay discounting water rate 0 sec1.01.62.1-1.4-1.4-1.2-0.9-1.4-0.9-1.4-1.3-1.0-1.4-1.4-1.3-1.3-0.7-1.3-1.4
Delay discounting water rate 12 sec0.30.41.0-0.7-0.6-0.6-1.0-0.7-0.5-0.8-0.9-0.4-0.7-0.7-0.6-0.6-0.1-0.7-0.8
Delay discounting water rate 18 sec0.10.10.40.30.20.4-0.70.4-0.10.20.10.60.20.20.30.30.50.2-0.1
Delay discounting water rate 24 sec0.30.42.4-0.3-0.0-0.11.1-0.71.0-1.0-0.6-1.5-0.3-0.3-0.1-0.1-0.5-0.3-0.1
Delay discounting water rate 6 sec0.10.21.4-0.2-0.4-0.2-1.2-0.0-0.8-0.1-0.40.6-0.2-0.3-0.2-0.20.2-0.3-0.6
Locomotor activity1.82.94.71.71.91.71.51.61.51.71.71.01.71.71.81.82.21.71.9
Locomotor testing distance1.01.63.31.21.71.21.41.01.31.01.00.31.21.21.21.21.81.21.6
Locomotor testing rearing0.40.63.80.01.0-0.12.0-0.41.2-0.50.1-1.50.00.10.10.1-0.20.01.0
Light reinforcement 10.10.10.70.10.90.10.70.10.5-0.00.1-0.30.20.20.20.20.30.10.6
Light reinforcement 20.71.03.5-1.1-0.4-0.71.0-1.20.2-1.4-0.9-1.9-0.8-0.8-0.9-0.9-0.8-0.9-0.5
Reaction time number correct1.01.46.30.71.50.72.50.22.2-0.00.7-1.50.80.80.90.9-0.30.81.3
Reaction time mean minus median0.20.30.5-0.7-0.4-0.5-0.3-0.7-0.2-0.4-0.4-0.7-0.6-0.6-0.6-0.6-0.2-0.5-0.1
Reaction time mean minus median AUC0.10.10.7-0.30.1-0.20.4-0.40.4-0.10.2-0.8-0.2-0.3-0.2-0.2-0.1-0.10.5
Reaction time num false alarms14.920.631.14.55.34.54.04.24.74.24.71.94.74.74.64.64.54.75.6
Reaction time num false alarms AUC13.819.428.54.45.14.43.64.24.44.34.62.14.54.64.54.54.54.65.3
Reaction time trials correct on left1.01.46.30.71.50.72.50.22.2-0.00.7-1.50.80.80.90.9-0.30.81.3
Reaction time trials on left1.01.46.20.71.50.72.50.22.2-0.10.7-1.60.80.80.90.9-0.30.81.3
Reaction time mean0.50.71.0-0.9-0.5-1.0-0.5-0.9-0.7-0.8-0.8-0.7-0.9-0.9-0.9-0.9-1.0-0.9-0.4
Reaction time mean AUC0.40.60.9-0.9-0.5-0.9-0.3-0.9-0.5-0.8-0.8-0.9-0.8-0.8-0.9-0.9-0.9-0.8-0.3
Median of all reaction times0.60.81.5-0.8-0.6-1.1-0.7-0.8-0.9-0.9-0.9-0.5-0.9-0.9-0.9-0.9-1.2-0.9-0.6
Reaction time omissions0.10.11.2-0.30.1-0.20.3-0.50.5-0.3-0.0-1.1-0.2-0.2-0.2-0.2-0.3-0.10.3
Reaction time false alarm rate7.811.015.43.43.43.41.73.52.53.73.52.73.43.43.33.33.93.53.9
Reaction time premature initiation rate1.41.94.51.51.41.40.11.40.91.41.41.31.31.41.41.42.11.41.3
Reaction time premature initiations2.23.14.81.82.21.81.41.52.11.41.70.41.81.81.91.92.01.82.0
Std. dev. reaction times0.10.20.7-0.00.60.10.6-0.10.70.10.4-0.70.10.10.10.10.10.30.8
Reaction time trials completed1.01.46.20.71.50.72.50.22.2-0.10.7-1.60.80.80.90.9-0.30.81.3
Reaction time trials AUC1.01.46.70.61.50.62.60.02.2-0.20.6-1.80.70.70.80.8-0.50.71.2
Social response proportion2.42.63.4-1.8-1.7-1.9-1.0-1.7-1.4-1.7-1.7-1.4-1.7-1.7-1.8-1.8-1.4-1.7-1.4
Social responses0.10.10.70.10.20.2-0.20.20.00.20.30.10.20.20.10.10.80.10.4
Social time0.81.11.61.10.71.10.31.30.61.11.11.01.21.21.11.11.21.10.9
Conditioned locomotion1.31.63.41.21.21.21.61.01.91.01.4-0.11.31.31.31.30.81.31.4
Cocaine response after cond. corrected0.20.20.70.20.80.20.7-0.00.60.10.3-0.50.10.10.20.2-0.30.20.7
Cocaine response after cond. not corrected0.20.20.80.40.90.30.70.20.50.20.5-0.20.30.30.40.4-0.20.40.8
Cocaine response before conditioning0.40.50.8-0.7-0.9-0.8-0.4-0.6-0.9-0.7-0.9-0.1-0.7-0.7-0.7-0.7-0.7-0.7-0.9
Saline control response0.10.10.7-0.3-0.9-0.3-0.4-0.1-0.4-0.3-0.40.3-0.2-0.2-0.2-0.20.5-0.3-0.6
Condit. Reinf. active minus inactive responses3.13.85.3-2.2-1.5-2.2-0.3-2.3-1.1-2.2-2.1-2.2-2.1-2.1-2.1-2.1-1.8-2.2-1.3
Condit. Reinf. active-inactive response ratio2.22.33.2-1.7-1.4-1.6-0.4-1.8-0.7-1.7-1.6-1.8-1.6-1.6-1.6-1.6-1.5-1.6-1.3
Condit. Reinf. active responses3.85.36.8-2.5-2.3-2.6-1.3-2.5-2.1-2.3-2.5-1.6-2.5-2.5-2.6-2.6-2.1-2.6-1.9
Condit. Reinf. inactive responses1.72.23.5-1.5-1.6-1.7-1.4-1.4-1.9-1.3-1.5-0.3-1.6-1.6-1.6-1.6-1.2-1.6-1.3
Condit. Reinf. lever presses5.37.39.5-3.0-2.4-3.0-0.8-3.1-1.7-3.1-3.0-2.7-2.9-2.9-2.9-2.9-2.5-2.9-2.1
Condit. Reinf. lever reinforcers received4.66.58.5-2.8-2.5-2.9-1.2-2.8-2.1-2.7-2.8-2.1-2.8-2.8-2.8-2.8-2.4-2.8-2.0
Pavlov. Cond. lever latency4.56.28.02.72.32.81.02.71.92.82.82.22.62.62.62.62.52.72.2
Pavlov. Cond. magazine entry latency5.15.911.7-2.6-1.5-2.50.7-3.0-0.5-2.9-2.4-3.4-2.5-2.5-2.5-2.5-3.2-2.5-1.4
Pavlov. Cond. change in total contacts6.99.712.7-3.4-2.5-3.5-0.8-3.6-2.0-3.5-3.4-3.2-3.3-3.3-3.3-3.3-3.5-3.4-2.5
Pavlov. Cond. index score6.58.511.3-3.2-2.4-3.3-0.5-3.3-1.7-3.4-3.1-3.1-3.1-3.1-3.1-3.1-3.3-3.1-2.3
Pavlov. Cond. latency score6.58.211.1-3.1-2.3-3.2-0.4-3.3-1.6-3.3-3.1-3.1-3.0-3.0-3.0-3.0-3.3-3.1-2.3
Pavlov. Cond. lever contacts2.63.75.0-2.0-1.7-2.2-0.6-2.1-1.4-2.2-2.2-1.8-2.0-2.0-2.0-2.0-2.0-2.1-1.6
Pavlov. Cond. magazine entry number7.79.412.83.52.53.40.63.61.83.53.23.23.33.33.33.33.23.32.5
Pavlov. Cond. intertrial magazine entries0.10.10.7-0.0-0.5-0.1-0.80.1-0.80.0-0.30.5-0.1-0.1-0.0-0.00.6-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.6.17.910.5-3.1-2.3-3.1-0.4-3.2-1.6-3.2-3.0-3.0-3.0-3.0-3.0-3.0-3.2-3.0-2.3
Pavlov. Cond. response bias4.56.28.2-2.7-2.1-2.9-0.6-2.8-1.6-2.8-2.7-2.5-2.6-2.6-2.7-2.7-2.8-2.7-2.0
Conditioned reinforcement - actives2.22.22.91.61.51.60.41.70.81.71.41.71.51.61.61.61.51.51.4
Conditioned reinforcement - inactives0.20.20.50.40.00.5-0.10.40.20.50.50.40.40.40.40.40.70.40.3
Conditioned locomotion1.11.32.71.21.01.2-0.11.30.21.41.11.61.11.11.11.11.61.11.0
Intermittent access intake day 1-15 change2.02.04.41.51.31.30.01.60.51.71.41.81.41.41.41.42.11.41.1
Intermittent access intake escalation1.41.43.21.21.21.10.21.30.51.31.21.31.11.11.11.11.81.21.0
Intermittent access intake escalation 21.11.11.81.11.41.00.61.00.71.11.10.81.01.01.01.01.31.11.1
Intermitt. access day 1 inactive lever presses0.80.92.00.81.21.01.10.61.30.61.0-0.40.90.90.90.91.40.91.1
Intermitt. access day 15 inactive lever presses1.51.62.81.31.61.31.31.11.51.11.30.31.31.31.31.30.91.31.7
Intermitt. access escalation Index3.63.24.01.91.91.81.91.72.01.71.90.71.91.91.91.91.01.92.0
Intermittent access day 1 total infusions0.10.20.30.30.10.40.30.40.40.30.40.30.40.40.40.40.50.40.4
Intermittent access day 15 total infusions0.60.72.00.90.80.80.10.90.20.90.71.10.80.80.80.81.40.80.6
Intermittent access terminal intake (last 3 days)1.61.73.01.41.41.30.71.40.91.41.21.21.31.41.41.41.71.31.4
Intermittent access total infusions0.30.30.90.60.60.60.20.60.20.60.50.70.50.60.60.61.00.50.6
Intermittent access day 1 locomotion0.20.20.30.40.30.50.50.40.50.30.50.10.50.50.50.50.60.50.4
Intermittent access day 15 total locomotion0.70.71.40.80.40.9-0.11.00.31.00.91.20.80.90.90.91.20.90.6
Intermittent access total locomotion1.31.52.71.20.81.30.31.40.71.41.41.31.31.31.31.31.71.31.0
Intermittent access standard deviation1.51.63.41.41.31.20.21.40.61.41.21.41.31.31.31.31.91.31.0
Cocaine induced anxiety0.30.30.6-0.4-0.5-0.40.0-0.7-0.2-0.7-0.7-0.7-0.6-0.5-0.5-0.5-0.8-0.6-0.5
Post-drug Anxiety0.40.42.0-0.10.10.31.4-0.41.1-0.40.1-1.40.10.10.10.1-0.60.10.7
Baseline Anxiety0.30.30.80.30.50.50.70.40.70.50.7-0.10.60.50.50.50.20.60.9
Lifetime Intake0.20.20.60.40.40.40.30.40.20.40.30.50.40.40.40.40.80.40.5
Incentive Sensitization - Responses5.05.06.12.42.22.41.52.32.12.22.21.42.42.52.52.51.92.42.5
Incentive Sensitization - Breakpoint5.05.06.12.42.22.41.62.32.12.22.21.42.42.52.52.52.02.42.5
Progressive ratio test 1 active lever presses0.10.20.4-0.4-0.7-0.3-0.3-0.3-0.5-0.3-0.50.1-0.4-0.3-0.3-0.30.3-0.4-0.6
Progressive ratio test 1 breakpoint0.10.20.4-0.3-0.6-0.2-0.5-0.2-0.6-0.2-0.40.3-0.3-0.3-0.3-0.30.6-0.3-0.5
Progressive ratio test 1 inactive lever presses0.50.51.40.40.80.81.00.31.20.30.6-0.50.60.60.60.60.90.60.9
Progressive ratio test 2 active lever presses2.22.33.81.61.31.71.11.61.21.51.41.21.61.61.61.61.91.51.6
Progressive ratio test 2 breakpoint2.22.43.71.61.41.71.11.61.31.51.41.21.61.71.71.71.91.61.6
Progressive ratio test 2 inactive lever presses0.00.10.60.00.10.20.20.00.1-0.1-0.2-0.00.00.10.10.10.8-0.00.2
Total sessions with >9 infusions0.50.51.3-0.9-0.6-0.60.4-0.9-0.1-0.9-0.7-1.1-0.8-0.7-0.7-0.7-0.1-0.7-0.6
Short access day 1 total inactive lever presses0.10.20.9-0.00.40.11.0-0.20.7-0.20.2-0.90.10.10.10.10.10.10.4
Short access day 10 total inactive lever presses1.81.93.61.31.41.51.91.01.91.01.6-0.31.41.41.41.40.91.41.8
Short access day 1 total infusions0.20.20.70.20.40.50.80.20.70.30.4-0.20.40.40.40.40.60.40.6
Short access day 10 total infusions0.20.30.5-0.5-0.4-0.5-0.0-0.6-0.3-0.7-0.6-0.5-0.5-0.5-0.5-0.5-0.7-0.6-0.4
Short access total infusions0.10.10.30.20.30.30.40.30.20.20.20.20.30.30.30.30.60.20.5
Short access day 1 locomotion0.30.30.5-0.6-0.6-0.6-0.4-0.6-0.6-0.6-0.5-0.3-0.7-0.6-0.6-0.6-0.3-0.6-0.7
Short access day 10 total locomotion0.00.00.2-0.0-0.20.0-0.40.1-0.20.20.20.30.00.00.00.00.40.1-0.2
Short access total locomotion0.00.00.3-0.3-0.2-0.0-0.0-0.2-0.0-0.2-0.0-0.2-0.2-0.1-0.1-0.10.5-0.1-0.2
Compulsive drug intake0.80.81.9-0.9-0.8-0.8-0.1-0.9-0.4-1.0-1.0-0.9-0.9-0.9-0.9-0.9-1.4-0.9-1.0
One hour access (0.3 mA shock)0.40.51.90.60.30.7-0.20.8-0.20.70.51.20.60.60.60.61.40.60.1
One hour access (shock baseline)0.60.72.60.80.70.9-0.10.90.10.80.81.10.70.80.80.81.60.80.6
Number of responses in last shaping day0.10.10.5-0.20.2-0.10.7-0.30.3-0.3-0.0-0.7-0.2-0.1-0.1-0.10.1-0.10.2
Context. condit. distance diff. score0.00.00.40.00.3-0.10.1-0.10.3-0.1-0.0-0.3-0.0-0.1-0.0-0.0-0.6-0.00.0
Locomotion velocity, session 10.40.40.7-0.7-0.2-0.8-0.7-0.6-0.7-0.6-0.7-0.2-0.7-0.8-0.8-0.8-0.7-0.7-0.3
Locomotion distance, session 10.00.00.1-0.1-0.2-0.10.1-0.10.2-0.10.0-0.2-0.1-0.1-0.1-0.1-0.0-0.00.1
Locomotion velocity, session 20.70.92.3-0.9-0.8-0.9-1.5-0.8-1.1-0.7-0.9-0.3-1.0-1.0-1.0-1.0-0.6-1.0-0.8
Locomotion distance, session 20.10.10.2-0.3-0.5-0.2-0.3-0.3-0.4-0.3-0.4-0.0-0.3-0.3-0.2-0.20.2-0.3-0.1
Locomotion velocity, session 30.30.31.10.70.20.50.00.8-0.10.70.41.00.60.60.60.60.50.50.3
Locomotion distance, session 30.10.10.4-0.3-0.6-0.3-0.3-0.2-0.3-0.2-0.20.1-0.3-0.3-0.3-0.3-0.3-0.2-0.5
Stereotopy head waving bouts, day 30.91.01.41.20.81.10.71.11.01.00.90.71.11.11.21.21.01.10.9
Stereotopy head waving duration, day 30.70.91.11.00.81.00.71.01.01.00.90.51.01.01.01.01.01.00.8
Locomotion velocity, session 70.30.41.70.40.70.41.30.11.10.00.2-0.80.40.40.50.5-0.20.30.7
Locomotion distance, session 70.40.51.6-0.5-0.2-0.61.0-0.80.3-0.9-0.7-1.2-0.5-0.5-0.5-0.5-1.3-0.6-0.1
Stereotopy head waving bouts, day 70.10.10.3-0.2-0.0-0.3-0.4-0.3-0.2-0.2-0.1-0.2-0.3-0.4-0.3-0.3-0.5-0.3-0.3
Stereotopy head waving duration, day 70.10.10.20.30.30.3-0.40.30.00.40.40.40.20.20.20.20.20.30.1
Locomotion velocity, session 80.81.01.6-1.0-1.0-1.0-0.8-0.8-1.3-0.9-1.1-0.1-1.0-1.1-1.1-1.1-1.1-1.1-1.1
Locomotion distance, session 80.00.00.2-0.2-0.1-0.2-0.0-0.2-0.0-0.3-0.3-0.3-0.2-0.2-0.2-0.2-0.4-0.2-0.1
Degree of sensitization distance0.30.31.50.20.60.21.2-0.10.9-0.10.2-0.80.20.20.20.2-0.40.20.6
Degree of sensitization stereotypy0.20.20.6-0.40.1-0.5-0.3-0.5-0.2-0.4-0.3-0.3-0.5-0.5-0.5-0.5-0.8-0.4-0.2
Condit. Reinf. active minus inactive responses0.70.84.30.21.40.32.1-0.11.5-0.20.4-1.40.30.30.30.30.00.31.4
Condit. Reinf. active-inactive response ratio0.60.73.1-0.80.2-0.61.4-1.00.6-1.0-0.7-1.8-0.6-0.6-0.6-0.6-0.6-0.60.3
Condit. Reinf. active responses1.01.24.90.71.90.72.20.31.70.30.9-0.90.70.70.70.70.30.71.8
Condit. Reinf. inactive responses1.11.42.51.21.61.01.31.01.30.91.30.41.11.11.11.10.91.21.5
Incentive salience index mean1.01.25.10.51.60.72.30.21.90.20.8-1.10.70.70.70.70.50.71.6
Condit. Reinf. lever presses0.20.21.1-0.30.1-0.01.0-0.50.7-0.50.0-1.0-0.2-0.1-0.2-0.2-0.3-0.10.2
Time in familiar zone, hab. session 10.30.31.4-0.3-0.4-0.6-0.9-0.3-1.2-0.3-0.60.4-0.5-0.5-0.5-0.5-0.2-0.5-0.5
Time in novel zone, hab. session 10.50.51.60.61.00.61.30.41.20.40.7-0.30.60.60.60.60.10.61.0
Total zone transitions, hab. session 10.00.00.1-0.3-0.3-0.10.1-0.1-0.1-0.2-0.0-0.0-0.1-0.2-0.2-0.20.0-0.1-0.0
Total locomotion distance, hab. session 10.10.20.50.20.20.40.30.40.10.50.50.70.30.30.30.30.50.40.4
Locomotion velocity, hab. session 10.10.10.60.2-0.00.4-0.10.40.00.50.50.80.30.30.20.20.50.40.2
Time in familiar zone, hab. session 20.40.42.00.50.20.3-0.90.7-0.60.80.61.40.40.40.40.40.90.50.2
Time in novel zone, hab. session 20.20.21.0-0.30.4-0.21.0-0.30.6-0.4-0.2-1.0-0.1-0.2-0.2-0.2-0.3-0.20.4
Total zone transitions, hab. session 20.70.91.70.70.91.01.30.71.30.81.10.10.80.90.80.81.01.01.2
Total locomotion distance, hab. session 22.12.83.91.71.51.71.11.81.41.82.01.71.71.71.71.71.51.81.6
Locomotion velocity, hab. session 21.11.52.31.30.81.40.51.40.81.51.51.51.31.31.31.31.11.41.1
Novel to familiar place preference ratio0.20.20.5-0.4-0.2-0.40.0-0.5-0.2-0.5-0.3-0.4-0.5-0.4-0.4-0.4-0.7-0.4-0.2
Novelty place preference0.10.10.2-0.4-0.1-0.4-0.2-0.4-0.4-0.3-0.2-0.1-0.4-0.4-0.4-0.4-0.5-0.3-0.2
Time in novel zone, NPP test0.20.30.4-0.5-0.1-0.6-0.3-0.5-0.6-0.5-0.4-0.2-0.6-0.6-0.6-0.6-0.6-0.5-0.3
Total zone transitions, NPP test0.20.40.7-0.7-0.8-0.6-0.7-0.5-0.6-0.5-0.50.0-0.6-0.7-0.6-0.6-0.3-0.6-0.7
Total locomotion distance, NPP test0.20.30.9-0.5-0.9-0.3-0.9-0.1-0.8-0.1-0.20.7-0.4-0.4-0.4-0.4-0.2-0.4-0.8
Locomotion velocity, NPP test0.30.41.3-0.5-1.1-0.4-1.1-0.2-0.9-0.2-0.30.7-0.5-0.5-0.5-0.5-0.3-0.4-1.0
Pavlov. Cond. lever latency0.10.10.80.30.10.1-0.70.4-0.50.50.20.90.20.10.10.10.30.2-0.1
Pavlov. Cond. magazine entry latency0.50.63.1-0.6-0.5-0.31.3-0.80.9-1.0-0.5-1.7-0.4-0.4-0.4-0.4-1.1-0.4-0.2
Pavlov. Cond. change in total contacts0.20.21.30.10.20.41.0-0.11.2-0.20.0-1.00.20.30.20.20.10.20.5
Pavlov. Cond. index score0.30.31.8-0.4-0.3-0.11.0-0.60.8-0.7-0.3-1.3-0.2-0.2-0.2-0.2-0.6-0.3-0.0
Pavlov. Cond. latency score0.40.52.0-0.7-0.5-0.40.8-0.80.5-0.9-0.5-1.4-0.5-0.4-0.5-0.5-0.7-0.5-0.2
Pavlov. Cond. lever contacts0.20.21.1-0.10.20.21.0-0.20.8-0.3-0.0-0.90.10.20.10.10.10.10.4
Pavlov. Cond. magazine entry number0.40.52.20.70.50.5-0.60.9-0.50.90.51.50.50.50.50.51.10.50.4
Pavlov. Cond. intertrial magazine entries1.01.23.00.71.21.11.70.81.60.61.0-0.21.00.90.90.91.50.91.4
Pavlov. Cond. lever-magazine prob. diff.0.20.21.4-0.3-0.3-0.00.9-0.50.8-0.6-0.2-1.2-0.2-0.1-0.1-0.1-0.4-0.20.0
Pavlov. Cond. response bias0.30.31.7-0.4-0.4-0.20.9-0.60.7-0.7-0.4-1.3-0.3-0.3-0.3-0.3-0.8-0.3-0.2
Bone: apparent density0.40.71.60.81.30.70.90.71.00.70.90.00.80.80.80.80.50.81.0
Bone surface0.30.51.40.51.00.61.20.40.90.40.7-0.20.60.60.60.60.70.60.8
Bone volume0.20.31.00.51.00.40.90.40.70.40.6-0.10.50.50.50.50.40.50.7
Bone: connectivity density0.71.11.71.11.31.01.01.01.11.01.10.21.11.11.21.20.91.11.1
Bone: cortical apparent density0.10.10.5-0.3-0.3-0.00.6-0.40.5-0.2-0.0-0.7-0.2-0.2-0.2-0.2-0.0-0.1-0.0
Bone: cortical area0.10.20.4-0.5-0.1-0.4-0.0-0.5-0.2-0.6-0.7-0.6-0.4-0.4-0.4-0.4-0.2-0.5-0.5
Bone: cortical porosity6.26.79.82.53.02.72.82.33.12.12.50.52.72.72.72.72.52.63.0
Bone: cortical porosity4.85.29.62.12.82.32.91.83.11.62.1-0.22.32.32.32.32.12.22.8
Bone: cortical thickness1.21.92.9-1.6-0.9-1.5-0.4-1.6-0.7-1.7-1.6-1.7-1.5-1.5-1.4-1.4-1.3-1.5-1.2
Bone: cortical thickness0.40.52.1-0.20.8-0.41.5-0.61.0-0.7-0.3-1.4-0.2-0.2-0.1-0.1-1.0-0.20.4
Bone: cortical tissue density0.10.10.5-0.2-0.20.10.7-0.20.6-0.10.1-0.6-0.1-0.1-0.0-0.00.10.00.1
Bone: elastic displacement0.60.61.5-0.8-0.8-0.9-1.2-0.6-1.1-0.5-0.70.0-0.8-0.8-0.8-0.8-0.3-0.8-0.8
Bone: elastic work0.10.20.4-0.60.1-0.50.2-0.5-0.1-0.6-0.5-0.6-0.4-0.4-0.4-0.40.2-0.4-0.1
Bone: endosteal estimation2.24.86.72.32.22.31.52.31.92.32.61.82.32.32.22.22.32.42.2
Bone: endosteal perimeter0.71.53.81.51.11.2-0.31.60.11.51.12.01.31.31.21.21.41.20.7
Bone: final force1.01.73.60.91.81.11.70.81.90.81.3-0.41.21.21.21.21.61.21.7
Bone: final moment0.91.43.00.81.60.91.60.71.70.81.2-0.41.11.11.11.11.51.11.6
Bone: marrow area2.35.06.82.32.32.31.62.32.02.32.61.72.32.32.22.22.32.42.3
Bone: maximum diameter0.30.51.6-0.3-0.6-0.5-1.2-0.1-1.3-0.3-0.70.7-0.4-0.4-0.4-0.4-0.5-0.6-1.2
Bone: maximum force0.30.51.20.41.00.51.10.41.10.40.7-0.30.60.60.60.61.00.60.8
Bone: maximum moment0.20.30.80.20.70.40.90.20.90.30.6-0.40.40.40.40.40.80.40.6
Bone: minimum diameter0.30.61.30.71.10.80.80.70.80.50.60.20.80.80.70.70.70.70.8
Bone: periosteal estimation0.71.41.91.21.41.21.01.21.11.11.30.81.31.31.21.21.31.21.2
Bone: periosteal perimeter0.10.21.00.50.60.2-0.60.6-0.50.40.11.00.40.40.30.30.50.3-0.0
Bone: post-yield work0.50.61.70.71.00.81.30.41.30.40.8-0.40.70.70.70.70.40.71.0
Bone: stiffness0.30.40.60.70.70.60.70.70.60.70.80.50.70.70.70.70.50.70.5
Bone: tissue strength2.72.65.3-2.0-1.1-1.70.0-2.0-0.5-2.0-1.6-2.3-1.7-1.7-1.7-1.7-1.3-1.7-1.0
Bone: trabecular number0.10.20.50.20.70.30.60.00.70.00.2-0.60.30.30.30.30.30.30.5
Bone: trabecular spacing1.31.72.1-1.3-1.2-1.4-1.4-1.3-1.4-1.2-1.4-0.6-1.4-1.4-1.4-1.4-1.4-1.4-1.0
Bone: trabecular thickness0.10.10.8-0.10.2-0.10.9-0.30.7-0.30.0-0.8-0.0-0.0-0.1-0.1-0.5-0.0-0.1
Bone: trabecular tissue density0.10.10.40.30.00.3-0.30.3-0.10.40.20.60.20.20.20.20.30.2-0.0
Breakpoint value in progressive ratio session0.30.40.6-0.7-0.5-0.7-0.5-0.7-0.6-0.5-0.6-0.5-0.8-0.8-0.7-0.7-0.1-0.6-0.6
Distance traveled before self-admin4.34.613.02.41.72.0-0.82.70.02.72.03.62.12.22.22.22.02.11.1
Distance traveled after self-admin3.43.85.52.41.92.00.82.31.32.11.91.82.22.22.22.21.22.11.8
Delta time in closed arm before/after self-admin0.50.51.90.40.60.71.40.21.30.30.6-0.90.50.60.60.60.40.60.9
Delta time in open arm before/after self-admin0.30.30.9-0.5-0.3-0.50.6-0.60.2-0.8-0.5-0.9-0.3-0.4-0.4-0.4-0.9-0.5-0.3
Diff in mean of infusions in LGA sessions0.20.20.8-0.3-0.9-0.3-0.7-0.2-0.7-0.1-0.20.3-0.4-0.4-0.3-0.3-0.4-0.3-0.7
Extinction: sum of active levers before priming2.32.34.3-1.7-1.4-1.4-0.0-1.9-0.5-1.8-1.5-2.1-1.6-1.6-1.6-1.6-1.3-1.5-1.5
Active lever presses in extinction session 60.50.51.3-0.6-0.8-0.7-1.1-0.4-1.1-0.2-0.60.4-0.7-0.7-0.6-0.6-0.1-0.6-0.9
Delta distance traveled before/after self-admin0.80.95.2-0.3-0.0-0.11.9-0.71.4-0.8-0.2-2.3-0.1-0.1-0.1-0.1-1.1-0.10.6
Delta ambulatory time before/after self-admin1.01.16.5-0.7-0.3-0.51.8-1.01.2-1.1-0.4-2.5-0.4-0.4-0.4-0.4-1.5-0.40.4
Time in closed arm before self-admin2.12.43.41.81.41.60.61.91.01.81.61.41.81.71.71.71.31.71.5
Time in closed arm after self-admin3.33.55.51.61.82.02.21.52.31.51.9-0.01.91.92.02.01.81.92.3
Time in open arm before self-admin1.21.21.8-1.1-1.2-1.2-1.3-1.1-1.3-0.9-1.2-0.3-1.3-1.3-1.1-1.1-0.4-1.2-1.3
Time in open arm after self-admin0.50.60.8-0.7-0.9-0.9-0.4-0.8-0.5-0.7-0.7-0.4-0.8-0.8-0.8-0.8-0.9-0.8-0.9
Sum of active levers in priming session hrs 5-63.23.25.8-1.9-1.4-1.8-0.0-2.2-0.5-2.1-1.8-2.4-1.9-1.9-1.8-1.8-2.1-1.8-1.5
Time to tail flick, vehicle, before self-admin0.20.21.20.30.40.31.10.00.9-0.20.1-1.00.30.30.30.3-0.30.20.5
Time to tail flick, vehicle, after self-admin4.85.19.02.22.42.22.91.83.01.72.4-0.32.32.32.32.31.52.42.8
Time to tail flick, test, before self-admin0.50.41.10.91.00.50.60.60.60.60.60.30.70.70.70.7-0.30.60.8
Time to tail flick, test, after self-admin0.20.30.9-0.4-0.2-0.6-0.1-0.6-0.3-0.5-0.5-0.4-0.5-0.5-0.5-0.5-0.9-0.5-0.5
Delta time to tail flick, vehicle, before/after SA3.13.04.41.71.81.71.41.71.71.82.10.91.81.81.71.71.61.92.1
Delta time to tail flick, test, before/after SA1.11.01.5-1.1-1.2-1.0-1.0-0.9-1.1-0.7-0.9-0.2-1.0-1.1-1.0-1.0-0.6-1.0-1.2
Ambulatory time before self-admin4.04.213.82.31.51.8-1.12.7-0.22.61.83.72.02.02.02.01.71.90.9
Ambulatory time after self-admin1.61.72.61.61.31.30.61.61.01.41.41.01.51.51.51.50.41.41.3
Total heroin consumption0.20.20.4-0.4-0.5-0.5-0.6-0.4-0.6-0.4-0.6-0.0-0.5-0.5-0.4-0.4-0.3-0.5-0.6
Area under the delay curve0.00.00.20.10.1-0.00.4-0.10.30.00.3-0.4-0.00.10.00.0-0.20.10.1
Delay disc. indifference point, 0s delay0.10.10.50.10.30.10.7-0.10.4-0.00.2-0.60.10.10.20.20.00.1-0.0
Delay disc. indifference point, 16s delay0.00.00.10.1-0.10.10.10.10.20.10.2-0.10.10.10.10.1-0.00.1-0.1
Delay disc. indifference point, 2s delay1.92.13.91.31.91.42.01.11.91.01.5-0.21.41.41.41.41.31.41.7
Delay disc. indifference point, 24s delay0.60.60.9-0.9-1.0-0.8-0.1-0.9-0.3-0.8-0.6-0.9-0.8-0.7-0.8-0.8-1.0-0.7-0.5
Delay disc. indifference point, 4s delay0.20.20.50.60.70.30.30.40.30.40.50.20.30.40.50.50.20.40.4
Delay disc. indifference point, 8s delay0.00.00.20.2-0.00.0-0.00.10.00.30.40.20.10.10.00.0-0.20.20.1
Delay discount exponential model param0.10.10.3-0.1-0.2-0.1-0.60.0-0.5-0.1-0.40.4-0.1-0.2-0.1-0.10.2-0.2-0.2
Delay discount hyperbolic model param0.20.20.4-0.4-0.5-0.3-0.6-0.2-0.6-0.3-0.60.2-0.3-0.4-0.4-0.4-0.1-0.4-0.5
Fecal boli incidents, locomotor time 10.00.10.30.10.2-0.00.5-0.00.40.10.0-0.30.10.10.10.1-0.10.10.5
Change in fecal boli incidents, locomotor task0.50.40.90.70.30.6-0.20.80.20.80.80.90.70.70.70.70.80.70.5
Time >=10cm from walls, locomotor time 12.22.25.81.61.21.3-0.61.80.01.81.52.41.41.41.41.42.01.41.0
Bouts of movement, locomotor time 14.34.89.4-2.0-2.2-2.3-3.0-1.6-3.1-1.6-2.20.2-2.2-2.2-2.1-2.1-2.0-2.2-2.6
Total resting periods, locomotor time 12.83.16.2-1.6-1.8-1.8-2.4-1.3-2.5-1.3-1.80.3-1.7-1.7-1.6-1.6-1.6-1.7-2.2
Rest time, locomotor task time 10.40.51.1-0.7-1.1-0.5-1.0-0.5-1.0-0.5-0.90.1-0.7-0.7-0.5-0.5-0.1-0.7-0.8
Distance moved, locomotor task time 12.93.24.91.72.01.81.81.62.01.72.20.61.91.91.71.71.61.91.9
Vertical activity count, locomotor time 12.42.54.01.71.61.50.71.71.21.82.01.41.71.71.61.61.21.71.6
Time >=10cm from walls, locomotor time 22.82.93.61.91.81.71.11.81.41.91.91.21.81.81.91.91.41.91.8
Bouts of movement, locomotor time 20.20.21.10.1-0.1-0.1-1.10.2-0.90.30.00.9-0.1-0.1-0.0-0.00.1-0.0-0.3
Total resting periods, locomotor time 20.30.31.60.0-0.2-0.2-1.30.2-1.10.2-0.11.0-0.2-0.2-0.1-0.1-0.0-0.1-0.5
Rest time, locomotor task time 22.22.56.4-1.4-2.0-1.3-2.5-0.9-2.5-0.9-1.41.0-1.4-1.4-1.4-1.4-1.0-1.4-2.0
Distance moved, locomotor task time 22.22.65.21.61.91.62.21.32.31.21.7-0.31.61.61.61.61.01.61.8
Vertical activity count, locomotor time 23.43.75.32.02.21.91.81.82.01.92.30.72.02.01.91.91.32.12.3
Weight adjusted by age4.24.75.8-2.3-2.0-2.4-1.5-2.3-2.0-2.0-2.1-1.5-2.4-2.4-2.4-2.4-2.3-2.3-2.2
Seeking ratio, delayed vs. immediate footshock3.23.65.9-1.9-2.4-1.8-1.2-2.0-1.4-2.1-2.0-1.5-1.9-1.9-1.9-1.9-2.0-2.0-2.1
Locomotion in novel chamber0.50.61.1-0.8-1.0-0.9-0.7-0.8-0.8-0.6-0.6-0.4-0.8-0.9-0.9-0.9-0.8-0.7-1.1
Locomotion in novel chamber post-restriction0.40.51.70.30.90.51.30.21.10.30.6-0.70.50.50.50.50.50.60.9
Progressive ratio0.30.41.5-0.2-0.9-0.2-1.20.2-1.00.3-0.11.2-0.2-0.2-0.2-0.20.4-0.2-0.7
Food seeking constrained by brief footshock1.51.83.7-1.1-1.2-1.1-1.7-1.1-1.7-1.3-1.6-0.1-1.4-1.3-1.3-1.3-1.0-1.5-1.9
Seeking ratio, punishment vs. effort0.20.20.7-0.30.1-0.30.0-0.5-0.1-0.7-0.7-0.8-0.4-0.4-0.4-0.4-0.7-0.5-0.5
Run reversals in cocaine runway, females0.60.62.30.51.00.61.50.21.20.40.8-0.50.50.50.60.6-0.10.71.2
Run reversals in cocaine runway, males0.30.30.60.60.70.50.20.60.10.50.50.70.50.50.50.50.60.50.5
Latency to leave start box in cocaine runway0.00.00.10.20.10.20.20.20.30.10.2-0.10.20.20.20.20.10.20.4
Latency to leave start box in cocaine runway, F0.10.10.9-0.20.2-0.00.8-0.30.5-0.4-0.1-0.9-0.0-0.1-0.1-0.1-0.4-0.10.4
Latency to leave start box in cocaine runway, M0.20.21.10.2-0.50.0-1.00.3-0.80.40.11.0-0.0-0.0-0.0-0.00.1-0.0-0.3
Cd content in liver2.62.83.8-1.7-1.6-1.9-2.0-1.5-2.0-1.6-1.8-0.5-1.8-1.7-1.7-1.7-1.4-1.8-1.7
Co content in liver0.20.30.8-0.4-0.6-0.4-0.6-0.4-0.7-0.4-0.50.0-0.5-0.5-0.5-0.5-0.4-0.5-0.9
Cu content in liver1.21.42.81.21.01.10.11.30.11.51.21.71.11.11.11.11.61.21.0
Fe content in liver0.40.40.7-0.8-0.7-0.6-0.8-0.7-0.7-0.7-0.6-0.3-0.7-0.7-0.7-0.7-0.2-0.7-0.5
K content in liver8.18.112.13.12.23.00.23.31.13.53.23.43.03.03.03.03.33.12.2
Mg content in liver1.41.52.71.31.01.30.21.40.31.51.21.71.21.31.31.31.51.30.8
Mn content in liver0.80.93.10.70.71.11.70.81.20.60.80.20.90.90.90.91.10.80.8
Na content in liver0.80.81.50.80.71.20.80.81.00.91.00.30.90.90.90.91.11.00.8
Rb content in liver2.53.15.7-1.8-2.4-1.8-1.7-1.5-2.3-1.3-1.6-0.1-1.9-1.8-1.8-1.8-1.1-1.7-2.1
Se content in liver0.20.31.4-0.00.40.41.2-0.11.0-0.10.1-0.80.20.20.20.20.60.20.8
Sr content in liver0.40.40.60.70.80.5-0.00.70.20.60.50.70.70.70.70.70.60.60.4
Zn content in liver2.52.83.61.91.71.70.51.90.91.81.71.71.81.81.81.81.91.81.4