Hub : Genes

Phf5a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	ENSRNOG00000024170	0.03	0.02	1.6e-03	0.01	0.02	0.02	0.02	1.8e-02	4.7e-03	4.1e-03	1.1e-02
2	PL	alternative TSS	ENSRNOT00000005837	0.06	0.04	8.1e-05	0.05	0.04	0.01	0.03	1.3e-04	4.1e-04	5.2e-02	2.6e-03
3	PL	alternative TSS	ENSRNOT00000113004	0.06	0.03	1.0e-04	0.05	0.05	0.01	0.03	1.2e-04	1.9e-04	3.5e-02	1.2e-03
4	PL	isoform ratio	ENSRNOT00000005837	0.04	0.03	2.5e-03	0.01	0.02	0	0.01	4.9e-02	1.2e-02	2.0e-01	9.7e-02
5	PL	isoform ratio	ENSRNOT00000113004	0.04	0.03	1.5e-03	0.01	0.02	0	0.01	3.4e-02	5.6e-03	1.7e-01	5.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.2	4.0	4.7	2.2	-2.0	2.0	-1.9	1.9
BMI without tail	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	-0.2
Body weight	1.8	7.4	8.5	2.7	-2.9	2.9	-2.5	2.5
Epididymis fat weight	4.4	10.3	11.0	3.3	-3.2	3.2	-3.2	3.2
Glucose	0.6	0.9	1.1	-0.7	0.9	-0.9	1.0	-1.0
Heart weight	1.5	2.2	3.6	1.9	-1.3	1.3	-1.4	1.4
Left kidney weight	13.4	38.4	39.3	6.1	-6.3	6.3	-6.2	6.2
Right kidney weight	14.0	39.9	40.4	6.3	-6.3	6.3	-6.3	6.4
Tail length	0.2	0.5	0.6	-0.6	0.8	-0.8	0.7	-0.7
Length with tail	0.4	1.6	2.1	1.2	-1.4	1.4	-1.2	1.2
Length without tail	1.8	4.0	5.1	1.6	-2.3	2.3	-1.9	1.9
Liver weight, left	0.9	1.4	1.8	1.3	-1.1	1.1	-1.2	1.2
Liver weight, right	3.2	5.2	5.8	2.4	-2.3	2.3	-2.3	2.2
Parametrial fat weight	0.1	0.2	0.3	0.5	-0.5	0.5	-0.5	0.5
Retroperitoneal fat weight	5.3	17.7	20.6	4.0	-4.5	4.5	-3.9	3.9
Intraocular pressure	0.5	0.6	0.9	0.8	-0.6	0.6	-0.9	0.9
Extensor digitorum longus weight	0.3	1.0	1.1	-0.9	1.1	-1.1	1.0	-1.1
Soleus weight	0.2	0.5	0.8	-0.9	0.8	-0.8	0.4	-0.4
Tibialis anterior weight	0.7	2.5	2.7	-1.6	1.6	-1.6	1.6	-1.5
Tibia length	0.9	2.6	3.0	1.4	-1.7	1.7	-1.6	1.6
Number of licking bursts	0.5	0.6	1.0	-1.0	0.8	-0.8	0.6	-0.6
Food consumed during 24 hour testing period	1.8	2.2	2.8	1.4	-1.7	1.7	-1.3	1.3
Times rat made contact with spout	0.8	0.9	1.0	0.7	-1.0	1.0	-1.0	1.0
Mean time between licks in bursts	0.6	0.8	0.9	-0.8	0.9	-0.9	0.9	-0.9
Mean num. licks in bursts	2.3	2.8	3.0	1.7	-1.7	1.7	-1.6	1.6
Std. dev. time between licks in bursts	1.8	2.2	2.4	-1.6	1.4	-1.4	1.5	-1.5
Water consumed over 24 hours	0.8	0.9	1.1	0.8	-1.0	1.0	-1.0	1.0
Indifference point 0 sec	0.8	1.2	1.3	-1.1	1.1	-1.1	1.2	-1.1
Indifference point AUC	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.0	0.0
Indifference point function ln k	1.1	1.6	2.2	1.3	-1.5	1.5	-1.0	0.9
Indifference point function log k	1.1	1.6	2.2	1.3	-1.5	1.5	-1.0	0.9
Delay discounting total patch changes 0 sec	0.9	1.5	1.6	-1.2	1.2	-1.2	1.3	-1.3
Delay discounting total patch changes 12 sec	0.1	0.1	0.1	-0.3	0.3	-0.3	0.1	-0.1
Delay discounting total patch changes 18 sec	0.4	0.5	0.7	-0.6	0.9	-0.9	0.5	-0.5
Delay discounting total patch changes 24 sec	0.5	0.6	1.1	-0.6	1.0	-1.0	0.6	-0.5
Delay discounting total patch changes 6 sec	0.6	0.9	1.2	-1.1	1.0	-1.0	0.8	-0.7
Delay discounting time to switch 0 sec	0.0	0.1	0.1	0.1	0.1	-0.1	0.4	-0.4
Delay discounting water rate 0 sec	0.2	0.3	0.6	-0.8	0.5	-0.5	0.6	-0.6
Delay discounting water rate 12 sec	0.5	0.7	0.8	-0.8	0.8	-0.8	0.9	-0.9
Delay discounting water rate 18 sec	1.6	2.1	3.0	-1.7	1.3	-1.3	1.5	-1.5
Delay discounting water rate 24 sec	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	-0.2
Delay discounting water rate 6 sec	0.9	1.3	1.5	-1.2	1.1	-1.1	1.1	-1.1
Locomotor activity	2.0	3.2	3.8	1.8	-1.9	1.9	-1.6	1.6
Locomotor testing distance	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1
Locomotor testing rearing	1.7	2.6	3.0	1.7	-1.6	1.6	-1.6	1.6
Light reinforcement 1	0.0	0.1	0.1	0.1	0.4	-0.4	-0.2	0.2
Light reinforcement 2	0.9	1.2	1.7	1.3	-1.0	1.0	-1.0	1.0
Reaction time number correct	0.7	1.0	1.3	-1.1	1.0	-1.0	0.9	-0.9
Reaction time mean minus median	0.1	0.1	0.2	0.4	-0.3	0.3	-0.3	0.3
Reaction time mean minus median AUC	0.8	1.0	1.2	1.1	-1.0	1.0	-0.9	0.9
Reaction time num false alarms	0.1	0.2	0.5	-0.1	0.7	-0.7	0.1	-0.1
Reaction time num false alarms AUC	0.3	0.4	0.9	-0.3	0.9	-0.9	0.2	-0.2
Reaction time trials correct on left	0.7	1.0	1.3	-1.1	1.0	-1.0	0.9	-0.9
Reaction time trials on left	0.7	1.1	1.4	-1.2	1.0	-1.0	0.9	-0.9
Reaction time mean	0.1	0.2	0.3	-0.3	0.3	-0.3	0.5	-0.6
Reaction time mean AUC	0.1	0.1	0.2	-0.3	0.2	-0.2	0.5	-0.5
Median of all reaction times	0.3	0.4	0.7	-0.6	0.5	-0.5	0.8	-0.8
Reaction time omissions	0.4	0.5	0.9	-0.6	0.9	-0.9	0.5	-0.5
Reaction time false alarm rate	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2	0.2
Reaction time premature initiation rate	0.4	0.5	0.7	-0.7	0.6	-0.6	0.8	-0.8
Reaction time premature initiations	0.5	0.7	0.9	-1.0	0.7	-0.7	1.0	-0.9
Std. dev. reaction times	0.2	0.3	0.6	0.7	-0.5	0.5	-0.5	0.5
Reaction time trials completed	0.7	1.1	1.4	-1.2	1.0	-1.0	0.9	-0.9
Reaction time trials AUC	0.5	0.7	1.0	-1.0	0.8	-0.8	0.8	-0.8
Social response proportion	0.1	0.1	0.2	0.2	-0.4	0.4	0.3	-0.3
Social responses	0.0	0.0	0.1	-0.4	0.2	-0.2	0.2	-0.2
Social time	1.8	2.4	2.8	-1.7	1.4	-1.4	1.6	-1.6
Conditioned locomotion	0.7	0.8	1.0	0.9	-0.7	0.7	-1.0	1.0
Cocaine response after cond. corrected	0.0	0.1	0.1	0.1	-0.3	0.3	-0.2	0.2
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0
Cocaine response before conditioning	0.2	0.3	0.5	-0.4	0.7	-0.7	0.5	-0.5
Saline control response	0.1	0.1	0.1	0.1	0.4	-0.4	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.1	-0.4	0.4	-0.1	0.1
Condit. Reinf. active responses	0.3	0.5	0.8	0.6	-0.5	0.5	-0.8	0.9
Condit. Reinf. inactive responses	0.9	1.2	1.7	1.0	-0.8	0.8	-1.3	1.3
Condit. Reinf. lever presses	0.4	0.5	0.6	-0.8	0.7	-0.7	0.7	-0.7
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.3	-0.3	0.3	-0.5	0.5
Pavlov. Cond. lever latency	1.6	2.2	2.6	1.5	-1.3	1.3	-1.6	1.6
Pavlov. Cond. magazine entry latency	4.3	4.9	6.0	-2.4	1.9	-1.9	2.5	-2.4
Pavlov. Cond. change in total contacts	0.9	1.2	1.8	-1.2	0.7	-0.7	1.3	-1.3
Pavlov. Cond. index score	2.9	3.8	4.7	-2.1	1.6	-1.6	2.2	-2.1
Pavlov. Cond. latency score	3.6	4.5	5.4	-2.3	1.8	-1.8	2.3	-2.3
Pavlov. Cond. lever contacts	1.4	2.0	2.5	-1.4	1.2	-1.2	1.6	-1.6
Pavlov. Cond. magazine entry number	2.0	2.5	3.3	1.7	-1.2	1.2	-1.8	1.8
Pavlov. Cond. intertrial magazine entries	3.0	3.9	4.3	2.1	-1.8	1.8	-2.1	2.1
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.9	4.9	-2.1	1.6	-1.6	2.2	-2.2
Pavlov. Cond. response bias	1.5	2.1	2.7	-1.5	1.2	-1.2	1.7	-1.6
Conditioned reinforcement - actives	0.4	0.4	0.9	0.5	-0.1	0.1	-1.0	1.0
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.4	0.6	-0.6	0.3	-0.3
Conditioned locomotion	1.7	2.0	2.7	1.4	-1.2	1.2	-1.6	1.7
Intermittent access intake day 1-15 change	0.6	0.6	0.9	-0.6	0.9	-0.9	0.6	-0.6
Intermittent access intake escalation	0.7	0.7	1.0	-0.7	1.0	-1.0	0.7	-0.7
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.4	0.7	-0.7	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.3	-0.2	0.2	-0.1	0.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.4	0.5	-0.4	0.4	-0.6	0.6
Intermitt. access escalation Index	0.0	0.0	0.1	-0.2	0.0	-0.0	0.3	-0.2
Intermittent access day 1 total infusions	0.8	0.9	1.2	1.0	-0.7	0.7	-1.1	1.1
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.1	0.5	-0.5	-0.0	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	0.3	0.2	-0.2	-0.3	0.4
Intermittent access total infusions	0.2	0.2	0.3	0.5	-0.4	0.4	-0.6	0.6
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	-0.3	0.3	-0.5	0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.4	-0.4	0.4	-0.4	0.4
Intermittent access total locomotion	0.4	0.5	0.5	0.7	-0.7	0.7	-0.7	0.7
Intermittent access standard deviation	0.3	0.3	0.7	0.8	-0.4	0.4	-0.6	0.6
Cocaine induced anxiety	1.1	1.3	2.2	1.1	-1.5	1.5	-0.7	0.7
Post-drug Anxiety	0.3	0.3	0.7	0.4	-0.8	0.8	-0.2	0.2
Baseline Anxiety	1.3	1.3	1.6	-1.3	1.2	-1.2	1.0	-1.0
Lifetime Intake	0.7	0.7	0.9	0.9	-0.7	0.7	-0.9	0.9
Incentive Sensitization - Responses	0.3	0.3	0.4	-0.6	0.6	-0.6	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	0.4	-0.4	0.2	-0.2
Progressive ratio test 1 active lever presses	0.6	0.6	0.6	0.7	-0.7	0.7	-0.8	0.8
Progressive ratio test 1 breakpoint	0.5	0.5	0.5	0.6	-0.7	0.7	-0.7	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.6	-0.2	0.2	-0.3	0.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.2	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.0	-0.0	0.0	-0.3	0.3
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.2	-0.6	1.1	-1.1	0.6	-0.5
Total sessions with >9 infusions	1.8	2.0	2.2	1.3	-1.4	1.4	-1.5	1.5
Short access day 1 total inactive lever presses	0.6	0.6	0.9	0.9	-0.6	0.6	-0.9	0.9
Short access day 10 total inactive lever presses	0.2	0.3	0.4	0.6	-0.3	0.3	-0.6	0.6
Short access day 1 total infusions	1.2	1.2	1.6	1.2	-0.9	0.9	-1.3	1.3
Short access day 10 total infusions	1.0	1.1	1.5	1.0	-1.2	1.2	-0.9	0.9
Short access total infusions	2.1	2.3	2.5	1.6	-1.4	1.4	-1.6	1.6
Short access day 1 locomotion	0.1	0.1	0.2	0.4	-0.3	0.3	-0.3	0.3
Short access day 10 total locomotion	0.1	0.1	0.2	0.1	0.4	-0.4	0.3	-0.3
Short access total locomotion	0.9	0.9	1.3	1.1	-0.8	0.8	-1.0	1.0
Compulsive drug intake	2.3	2.3	3.2	-1.8	1.6	-1.6	1.2	-1.2
One hour access (0.3 mA shock)	0.5	0.6	1.2	-0.5	1.1	-1.1	0.4	-0.4
One hour access (shock baseline)	0.1	0.2	0.4	0.6	-0.3	0.3	-0.3	0.3
Number of responses in last shaping day	1.1	1.1	1.3	-1.1	0.9	-0.9	1.1	-1.1
Context. condit. distance diff. score	7.6	9.3	10.5	3.2	-3.0	3.0	-3.0	3.0
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.3	0.3
Locomotion distance, session 1	2.0	2.6	3.9	-2.0	1.7	-1.7	1.3	-1.3
Locomotion velocity, session 2	0.2	0.2	0.2	0.4	-0.4	0.4	-0.5	0.5
Locomotion distance, session 2	2.9	4.1	5.1	-2.3	2.0	-2.0	1.9	-1.9
Locomotion velocity, session 3	0.3	0.3	0.4	0.5	-0.5	0.5	-0.7	0.7
Locomotion distance, session 3	0.6	0.7	1.0	-1.0	0.9	-0.9	0.5	-0.5
Stereotopy head waving bouts, day 3	0.8	1.0	1.2	0.9	-1.1	1.1	-0.9	0.9
Stereotopy head waving duration, day 3	3.0	3.6	4.1	2.0	-1.9	1.9	-1.8	1.8
Locomotion velocity, session 7	0.4	0.4	0.5	0.5	-0.7	0.7	-0.6	0.6
Locomotion distance, session 7	0.0	0.0	0.1	-0.0	-0.3	0.3	-0.1	0.1
Stereotopy head waving bouts, day 7	2.5	2.8	3.1	1.8	-1.7	1.7	-1.7	1.7
Stereotopy head waving duration, day 7	1.8	2.2	2.8	1.7	-1.4	1.4	-1.4	1.4
Locomotion velocity, session 8	1.9	2.3	2.7	1.5	-1.4	1.4	-1.6	1.6
Locomotion distance, session 8	0.8	1.2	1.5	1.2	-0.9	0.9	-1.1	1.1
Degree of sensitization distance	2.4	2.4	3.0	1.7	-1.7	1.7	-1.2	1.2
Degree of sensitization stereotypy	1.7	1.9	2.1	1.4	-1.3	1.3	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.5	0.3	-0.3	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	0.5	-0.5	0.5	-0.5	0.5
Condit. Reinf. active responses	1.7	2.1	2.3	-1.4	1.5	-1.5	1.4	-1.4
Condit. Reinf. inactive responses	3.7	4.4	5.3	-1.8	2.3	-2.3	2.0	-2.0
Incentive salience index mean	0.5	0.6	0.7	-0.9	0.8	-0.8	0.7	-0.7
Condit. Reinf. lever presses	1.0	1.3	1.6	-1.1	1.3	-1.3	1.0	-1.0
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.2	-0.2	0.2	-0.5	0.5
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.7	-0.6	0.6	-0.3	0.3
Total zone transitions, hab. session 1	3.0	4.3	5.6	-2.4	2.2	-2.2	1.7	-1.7
Total locomotion distance, hab. session 1	1.4	2.1	2.8	-1.5	1.7	-1.7	1.1	-1.1
Locomotion velocity, hab. session 1	2.0	2.9	3.7	-1.7	1.9	-1.9	1.4	-1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.3	0.0	-0.0	-0.3	0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1	-0.0
Total zone transitions, hab. session 2	1.0	1.4	1.9	-1.4	1.3	-1.3	0.9	-0.9
Total locomotion distance, hab. session 2	1.1	1.4	1.7	-1.2	1.3	-1.3	1.0	-1.0
Locomotion velocity, hab. session 2	1.8	2.4	2.9	-1.6	1.7	-1.7	1.4	-1.4
Novel to familiar place preference ratio	2.5	2.6	2.9	1.6	-1.7	1.7	-1.6	1.5
Novelty place preference	3.7	3.8	4.1	1.9	-2.0	2.0	-1.9	1.9
Time in novel zone, NPP test	4.6	4.9	5.1	2.2	-2.3	2.3	-2.1	2.1
Total zone transitions, NPP test	2.7	3.9	5.0	-2.2	2.2	-2.2	1.6	-1.6
Total locomotion distance, NPP test	1.5	2.0	2.5	-1.6	1.5	-1.5	1.2	-1.2
Locomotion velocity, NPP test	2.3	3.2	3.7	-1.9	1.9	-1.9	1.6	-1.6
Pavlov. Cond. lever latency	1.2	1.5	1.6	1.3	-1.3	1.3	-1.2	1.2
Pavlov. Cond. magazine entry latency	0.7	1.0	1.4	-1.2	0.9	-0.9	0.9	-0.9
Pavlov. Cond. change in total contacts	1.4	1.5	1.8	-1.4	1.2	-1.2	1.1	-1.1
Pavlov. Cond. index score	0.3	0.4	0.6	-0.8	0.6	-0.6	0.6	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.8	0.6	-0.6	0.6	-0.6
Pavlov. Cond. lever contacts	1.5	1.8	2.0	-1.3	1.4	-1.4	1.3	-1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	0.9	-0.6	0.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	1.2	1.4	1.6	-1.3	1.1	-1.1	1.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	-0.9	0.7	-0.7	0.7	-0.7
Pavlov. Cond. response bias	0.7	0.8	1.1	-1.1	0.9	-0.9	0.9	-0.9
Bone: apparent density	0.3	0.5	0.7	-0.7	0.6	-0.6	0.8	-0.8
Bone surface	0.1	0.2	0.4	-0.7	0.4	-0.4	0.4	-0.4
Bone volume	0.0	0.0	0.0	-0.2	0.1	-0.1	0.2	-0.2
Bone: connectivity density	0.1	0.2	0.3	-0.4	0.2	-0.2	0.5	-0.5
Bone: cortical apparent density	0.6	0.8	1.1	-1.0	1.0	-1.0	0.8	-0.7
Bone: cortical area	1.5	2.2	2.4	1.6	-1.5	1.5	-1.4	1.4
Bone: cortical porosity	0.3	0.4	0.6	0.8	-0.6	0.6	-0.5	0.5
Bone: cortical porosity	1.0	1.1	1.4	1.2	-1.1	1.1	-0.9	0.9
Bone: cortical thickness	0.1	0.2	0.3	0.5	-0.6	0.6	-0.4	0.4
Bone: cortical thickness	0.3	0.3	0.4	0.5	-0.5	0.5	-0.6	0.6
Bone: cortical tissue density	0.6	0.8	1.0	-1.0	1.0	-1.0	0.7	-0.7
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2
Bone: elastic work	1.7	2.3	2.6	1.6	-1.6	1.6	-1.3	1.3
Bone: endosteal estimation	0.6	1.3	1.4	1.2	-1.1	1.1	-1.2	1.2
Bone: endosteal perimeter	1.8	3.7	4.1	2.0	-1.9	1.9	-1.9	1.9
Bone: final force	1.7	2.7	3.8	1.4	-1.9	1.9	-1.4	1.4
Bone: final moment	1.8	2.9	3.8	1.5	-2.0	2.0	-1.5	1.5
Bone: marrow area	0.7	1.4	1.6	1.3	-1.2	1.2	-1.2	1.2
Bone: maximum diameter	3.9	7.2	7.7	2.8	-2.7	2.7	-2.6	2.6
Bone: maximum force	2.8	4.8	5.7	2.1	-2.4	2.4	-2.0	2.0
Bone: maximum moment	3.0	5.2	6.1	2.2	-2.5	2.5	-2.1	2.1
Bone: minimum diameter	0.5	1.0	1.3	1.2	-1.0	1.0	-1.0	1.0
Bone: periosteal estimation	1.4	2.8	3.1	1.8	-1.7	1.7	-1.6	1.6
Bone: periosteal perimeter	3.8	6.4	7.1	2.7	-2.6	2.6	-2.4	2.4
Bone: post-yield work	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4	0.5
Bone: stiffness	1.6	2.5	3.0	1.6	-1.7	1.7	-1.4	1.4
Bone: tissue strength	0.1	0.1	0.2	0.2	-0.4	0.4	-0.2	0.2
Bone: trabecular number	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	0.1
Bone: trabecular spacing	1.2	1.6	1.8	1.1	-1.4	1.4	-1.2	1.2
Bone: trabecular thickness	0.2	0.3	0.4	-0.3	0.6	-0.6	0.6	-0.6
Bone: trabecular tissue density	2.1	3.0	3.5	-1.7	1.6	-1.6	1.9	-1.9
Breakpoint value in progressive ratio session	0.2	0.2	0.2	-0.4	0.5	-0.5	0.5	-0.5
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1
Distance traveled after self-admin	0.0	0.0	0.1	-0.3	0.2	-0.2	0.1	-0.1
Delta time in closed arm before/after self-admin	1.5	1.5	2.1	1.2	-1.0	1.0	-1.4	1.5
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.3	0.8	-0.8	0.6	-0.6
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	-0.8	0.1	-0.1	0.4	-0.3
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	0.2	-0.2	0.0	-0.0
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	0.0	-0.0	-0.2	0.2
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.2	-0.3	0.3	-0.6	0.7
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.2	-0.3	0.3	-0.6	0.6
Time in closed arm before self-admin	6.6	7.5	9.5	-2.7	2.4	-2.4	3.1	-3.1
Time in closed arm after self-admin	0.3	0.4	0.4	0.6	-0.6	0.6	-0.6	0.6
Time in open arm before self-admin	0.2	0.2	0.3	0.4	-0.2	0.2	-0.6	0.6
Time in open arm after self-admin	0.3	0.3	0.5	-0.3	0.7	-0.7	0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.1	0.2	-0.2	0.3	-0.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.0	-0.3	0.3	-0.1	0.1
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.0	-1.0	1.0	-1.0	0.9	-0.9
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.1	-0.1	0.1	-0.5	0.5
Time to tail flick, test, after self-admin	1.7	1.7	2.5	-1.0	1.6	-1.6	1.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.3	0.4	-0.4	0.5	-0.5
Delta time to tail flick, test, before/after SA	3.8	3.4	3.9	-1.6	2.0	-2.0	1.8	-1.8
Ambulatory time before self-admin	0.1	0.1	0.3	-0.1	0.5	-0.5	0.2	-0.2
Ambulatory time after self-admin	0.8	0.9	1.2	-1.0	1.1	-1.1	0.8	-0.7
Total heroin consumption	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2	0.2
Area under the delay curve	0.1	0.1	0.2	-0.5	0.2	-0.2	0.1	-0.1
Delay disc. indifference point, 0s delay	0.7	0.7	1.0	1.0	-0.9	0.9	-0.8	0.7
Delay disc. indifference point, 16s delay	1.2	1.2	1.7	-1.3	1.0	-1.0	1.1	-1.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.2	-0.4	0.4	-0.5	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.3	0.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	0.2	-0.2	0.0	-0.0
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	-0.9	0.7	-0.7	0.6	-0.6
Delay discount exponential model param	0.1	0.1	0.3	0.6	-0.3	0.3	-0.2	0.1
Delay discount hyperbolic model param	0.0	0.0	0.2	0.4	-0.2	0.2	-0.0	-0.0
Fecal boli incidents, locomotor time 1	0.3	0.3	0.5	-0.7	0.5	-0.5	0.6	-0.6
Change in fecal boli incidents, locomotor task	0.8	0.8	1.1	0.6	-0.8	0.8	-1.0	1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	-0.4	0.4	-0.2	0.2
Bouts of movement, locomotor time 1	0.8	0.9	1.4	0.6	-1.2	1.2	-0.8	0.8
Total resting periods, locomotor time 1	0.4	0.5	0.9	0.3	-0.9	0.9	-0.4	0.4
Rest time, locomotor task time 1	0.6	0.7	1.2	0.6	-1.1	1.1	-0.5	0.5
Distance moved, locomotor task time 1	0.4	0.4	0.7	0.8	-0.4	0.4	-0.7	0.7
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	0.3	-0.3	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.5	0.4	-0.4	0.4	-0.4
Bouts of movement, locomotor time 2	0.3	0.3	0.4	0.5	-0.6	0.6	-0.5	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.4	-0.6	0.6	-0.4	0.4
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.4	0.1	-0.1	0.2	-0.2
Distance moved, locomotor task time 2	0.7	0.8	1.3	1.1	-0.7	0.7	-0.9	0.9
Vertical activity count, locomotor time 2	0.2	0.3	0.6	0.7	-0.3	0.3	-0.6	0.6
Weight adjusted by age	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.2	0.2
Seeking ratio, delayed vs. immediate footshock	3.6	4.1	4.4	-2.1	2.0	-2.0	2.1	-2.1
Locomotion in novel chamber	1.6	2.0	4.1	-0.7	2.0	-2.0	0.8	-0.8
Locomotion in novel chamber post-restriction	1.0	1.2	1.6	-0.9	1.3	-1.3	1.0	-1.0
Progressive ratio	0.2	0.2	0.3	-0.3	0.5	-0.5	0.6	-0.6
Food seeking constrained by brief footshock	1.6	2.0	2.3	1.5	-1.3	1.3	-1.5	1.5
Seeking ratio, punishment vs. effort	0.9	1.1	1.3	0.9	-1.0	1.0	-1.2	1.2
Run reversals in cocaine runway, females	0.8	0.8	1.4	-0.8	1.2	-1.2	0.5	-0.5
Run reversals in cocaine runway, males	0.9	0.8	1.4	0.8	-0.6	0.6	-1.2	1.2
Latency to leave start box in cocaine runway	0.4	0.4	0.6	0.7	-0.8	0.8	-0.5	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.5	0.4	-0.4	0.5	-0.5
Latency to leave start box in cocaine runway, M	2.9	2.8	3.3	1.8	-1.8	1.8	-1.5	1.5
Cd content in liver	0.8	0.9	1.1	1.0	-0.8	0.8	-1.1	1.1
Co content in liver	0.2	0.2	0.3	0.5	-0.5	0.5	-0.5	0.5
Cu content in liver	4.8	5.7	5.8	-2.4	2.4	-2.4	2.4	-2.4
Fe content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2
K content in liver	0.9	0.9	1.0	-1.0	0.9	-0.9	1.0	-0.9
Mg content in liver	1.6	1.6	1.9	-1.3	1.2	-1.2	1.4	-1.4
Mn content in liver	0.2	0.2	0.4	0.5	-0.2	0.2	-0.6	0.6
Na content in liver	3.3	3.5	3.6	-1.9	1.8	-1.8	1.9	-1.9
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	-0.1
Se content in liver	0.8	0.9	1.1	-1.0	1.0	-1.0	0.9	-0.9
Sr content in liver	0.8	0.7	0.9	-0.8	1.0	-1.0	0.7	-0.7
Zn content in liver	1.5	1.6	1.7	-1.3	1.3	-1.3	1.2	-1.2