Ube2u

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000023895	0.24	0.14	2.4e-05	0.07	0.08	0.06	0.08	1.3e-04	5.2e-05	4.5e-04	4.6e-05
2	Brain	gene expression	ENSRNOG00000023895	0.07	0.04	1.8e-07	0.06	0.08	0.08	0.08	1.7e-06	3.5e-08	4.9e-08	1.0e-07
3	Brain	intron excision ratio	chr5:115118981:115122334	0.07	0.05	2.7e-04	0.04	0.02	0.04	0.04	1.2e-04	5.7e-03	1.3e-04	8.1e-05
4	NAcc	gene expression	ENSRNOG00000023895	0.12	0.06	3.6e-09	0.11	0.12	0.11	0.11	8.1e-09	3.1e-09	7.5e-09	2.1e-08
5	PL	gene expression	ENSRNOG00000023895	0.12	0.06	6.4e-07	0.02	0.07	0.04	0.05	1.8e-02	9.9e-06	2.8e-04	6.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.7	2.3	3.8	-1.6	-1.9	1.3	-0.1	-1.9
BMI without tail	0.3	0.5	1.3	-1.0	-0.4	0.4	1.1	-0.1
Body weight	0.1	0.6	0.9	-0.4	-0.8	0.5	-0.9	-0.9
Epididymis fat weight	0.2	0.6	2.1	0.1	0.4	-1.5	-0.5	0.5
Glucose	0.7	1.1	1.8	-1.0	-1.3	0.9	-0.3	-1.3
Heart weight	0.9	1.2	3.9	0.6	0.1	-1.3	-2.0	-0.2
Left kidney weight	0.4	1.2	4.7	-0.4	-0.8	0.2	-2.2	-0.8
Right kidney weight	0.5	1.5	7.0	-0.0	-0.3	-0.5	-2.6	-0.4
Tail length	0.6	1.9	3.2	0.9	1.5	-1.8	0.1	1.8
Length with tail	0.3	1.1	1.3	1.1	1.0	-1.0	-1.1	1.0
Length without tail	0.4	0.8	3.0	0.3	-0.4	0.5	-1.7	-0.7
Liver weight, left	0.6	1.0	3.2	0.8	0.1	-1.8	-1.2	-0.1
Liver weight, right	2.0	3.3	9.2	1.1	0.1	-2.4	-3.0	-0.4
Parametrial fat weight	2.2	4.4	7.8	-2.8	-2.2	2.3	1.0	-1.8
Retroperitoneal fat weight	0.1	0.4	0.5	0.7	0.7	-0.5	-0.3	0.6
Intraocular pressure	0.4	0.5	0.8	0.8	0.9	-0.7	0.0	0.8
Extensor digitorum longus weight	0.4	1.4	6.5	0.2	-0.3	-0.6	-2.6	-0.4
Soleus weight	0.1	0.3	0.7	-0.7	-0.0	-0.3	0.9	0.4
Tibialis anterior weight	4.6	15.8	30.2	-4.9	-3.4	5.5	2.9	-2.3
Tibia length	0.7	2.0	5.5	0.8	0.6	-2.3	-1.8	0.7
Number of licking bursts	0.1	0.1	0.2	0.2	-0.0	0.4	0.2	-0.3
Food consumed during 24 hour testing period	0.5	0.6	1.0	0.1	0.6	-1.0	1.0	0.9
Times rat made contact with spout	0.9	1.0	1.6	-1.3	-1.2	0.9	0.4	-1.0
Mean time between licks in bursts	3.6	5.0	9.1	2.7	1.2	-3.0	-2.7	0.5
Mean num. licks in bursts	0.4	0.4	1.4	-1.2	-0.8	0.3	0.1	-0.3
Std. dev. time between licks in bursts	1.0	1.2	2.5	0.4	-1.0	-0.1	-1.6	-1.6
Water consumed over 24 hours	2.6	3.0	5.2	-1.9	-2.3	1.0	-0.1	-2.2
Indifference point 0 sec	5.5	8.8	16.7	-2.9	-2.9	4.1	1.5	-2.9
Indifference point AUC	0.7	0.9	2.3	-0.7	-0.5	1.0	1.5	-0.4
Indifference point function ln k	0.4	0.5	1.3	0.2	0.0	-1.1	-1.1	0.0
Indifference point function log k	0.4	0.5	1.3	0.2	0.0	-1.1	-1.1	0.0
Delay discounting total patch changes 0 sec	5.4	8.8	15.7	-2.8	-3.0	4.0	1.5	-3.0
Delay discounting total patch changes 12 sec	1.4	1.9	4.7	-0.8	-1.2	2.2	0.8	-1.4
Delay discounting total patch changes 18 sec	4.1	5.4	7.9	-2.2	-2.6	2.8	1.1	-2.5
Delay discounting total patch changes 24 sec	2.5	3.2	4.6	-1.7	-2.0	2.1	0.1	-2.0
Delay discounting total patch changes 6 sec	3.2	4.9	11.3	-2.2	-1.8	3.4	1.6	-1.6
Delay discounting time to switch 0 sec	1.7	2.5	4.4	1.6	2.1	-1.2	-0.1	2.1
Delay discounting water rate 0 sec	0.7	1.2	2.3	-1.1	-1.0	1.5	0.6	-1.0
Delay discounting water rate 12 sec	3.9	5.8	8.7	-3.0	-2.9	2.2	0.8	-2.6
Delay discounting water rate 18 sec	0.9	1.2	1.9	-1.0	-1.4	1.1	-0.1	-1.4
Delay discounting water rate 24 sec	0.6	0.8	1.6	-0.4	-1.1	0.3	-1.0	-1.3
Delay discounting water rate 6 sec	0.2	0.3	0.5	-0.2	-0.7	-0.2	-0.6	-0.7
Locomotor activity	0.0	0.1	0.2	-0.3	-0.1	0.4	-0.3	-0.1
Locomotor testing distance	1.0	1.7	3.1	-1.6	-1.1	1.8	0.9	-0.8
Locomotor testing rearing	0.1	0.2	0.4	-0.4	-0.3	0.7	0.2	-0.3
Light reinforcement 1	0.5	0.9	1.8	-0.9	-1.4	-0.2	-0.3	-1.3
Light reinforcement 2	0.1	0.1	0.4	0.0	-0.1	-0.6	-0.6	-0.1
Reaction time number correct	0.6	0.9	1.5	0.5	0.9	-0.9	1.2	1.0
Reaction time mean minus median	1.0	1.3	3.2	-1.1	-0.6	1.3	1.8	-0.3
Reaction time mean minus median AUC	0.4	0.5	1.8	-0.6	-0.2	0.6	1.3	0.0
Reaction time num false alarms	0.1	0.1	0.4	0.0	0.0	0.4	0.6	0.1
Reaction time num false alarms AUC	0.4	0.5	1.4	-0.6	-0.3	0.9	1.2	-0.1
Reaction time trials correct on left	0.6	0.9	1.5	0.5	0.9	-0.9	1.2	1.0
Reaction time trials on left	0.6	0.8	1.7	0.4	0.9	-0.8	1.3	1.0
Reaction time mean	0.4	0.5	1.5	-0.6	-0.4	1.2	0.8	-0.3
Reaction time mean AUC	0.2	0.3	0.8	-0.3	-0.4	0.9	0.4	-0.4
Median of all reaction times	0.2	0.2	0.9	-0.1	-0.0	0.9	0.6	-0.0
Reaction time omissions	0.9	1.3	1.8	-1.2	-1.0	1.4	1.2	-0.9
Reaction time false alarm rate	0.6	0.8	2.0	-0.8	-0.7	1.4	0.6	-0.6
Reaction time premature initiation rate	0.2	0.2	0.6	-0.0	-0.4	-0.1	-0.8	-0.5
Reaction time premature initiations	0.1	0.1	0.5	0.3	0.1	-0.7	-0.2	0.1
Std. dev. reaction times	2.0	2.7	4.3	-1.8	-1.4	2.1	1.7	-1.1
Reaction time trials completed	0.6	0.8	1.7	0.4	0.9	-0.8	1.3	1.0
Reaction time trials AUC	0.6	0.9	1.7	0.4	0.9	-0.8	1.3	1.1
Social response proportion	0.4	0.5	1.4	0.2	0.6	0.2	1.2	0.7
Social responses	0.3	0.3	0.7	-0.3	-0.7	0.0	0.6	-0.8
Social time	0.3	0.4	0.8	-0.4	-0.4	0.6	0.9	-0.5
Conditioned locomotion	0.0	0.1	0.1	-0.3	-0.2	0.3	0.2	-0.3
Cocaine response after cond. corrected	0.4	0.4	1.3	-0.3	-0.1	1.2	0.8	-0.1
Cocaine response after cond. not corrected	0.6	0.6	1.2	-0.7	-0.5	1.1	0.9	-0.5
Cocaine response before conditioning	0.3	0.4	0.9	-0.9	-0.8	-0.2	0.5	-0.5
Saline control response	0.0	0.0	0.1	-0.2	0.1	0.2	0.4	0.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.8	-0.3	-0.2	-0.9	-0.1	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.5	-0.4	-0.2	0.6	-0.2
Condit. Reinf. active responses	0.3	0.4	0.7	-0.8	-0.8	-0.6	-0.2	-0.6
Condit. Reinf. inactive responses	0.3	0.4	1.1	0.2	0.1	-1.1	-0.9	0.1
Condit. Reinf. lever presses	3.7	5.0	7.7	-2.8	-2.2	2.1	2.4	-1.6
Condit. Reinf. lever reinforcers received	0.3	0.5	1.0	-0.9	-1.0	-0.2	0.0	-0.7
Pavlov. Cond. lever latency	1.5	2.0	5.9	1.5	0.5	-1.2	-2.4	-0.1
Pavlov. Cond. magazine entry latency	1.4	1.6	3.8	-1.3	-0.6	1.4	1.9	-0.3
Pavlov. Cond. change in total contacts	1.3	1.9	4.4	-1.6	-0.7	1.3	2.1	-0.2
Pavlov. Cond. index score	1.6	2.1	3.8	-1.8	-1.1	1.5	1.9	-0.6
Pavlov. Cond. latency score	1.5	1.8	3.2	-1.7	-1.1	1.3	1.8	-0.7
Pavlov. Cond. lever contacts	2.2	3.1	8.7	-1.9	-0.8	1.6	2.9	-0.2
Pavlov. Cond. magazine entry number	0.5	0.6	1.7	0.8	0.2	-0.9	-1.3	-0.1
Pavlov. Cond. intertrial magazine entries	1.8	2.4	3.7	1.9	1.7	-1.4	-1.1	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.5	-1.7	-1.0	1.4	1.9	-0.6
Pavlov. Cond. response bias	1.7	2.4	6.6	-1.6	-0.6	1.5	2.6	0.0
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.2	0.3	-0.3	0.4	0.6
Conditioned reinforcement - inactives	0.5	0.5	1.3	-0.2	-0.7	-0.1	-1.2	-0.9
Conditioned locomotion	0.1	0.2	0.4	-0.6	-0.3	0.4	0.2	-0.2
Intermittent access intake day 1-15 change	3.7	3.7	7.0	1.7	2.4	-1.6	0.5	2.6
Intermittent access intake escalation	3.5	3.4	6.5	1.7	2.4	-1.4	0.5	2.6
Intermittent access intake escalation 2	1.3	1.2	2.3	0.9	1.4	-1.0	0.5	1.5
Intermitt. access day 1 inactive lever presses	2.6	2.8	4.3	-1.8	-2.1	1.1	-1.2	-2.0
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.1	-0.5	-0.6	-1.0	-0.7	-0.5
Intermitt. access escalation Index	2.5	2.2	3.8	1.5	1.9	-0.9	0.7	1.9
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.2	0.1	0.0	0.3
Intermittent access day 15 total infusions	2.3	2.5	5.4	1.4	2.1	-0.9	0.5	2.3
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.3	0.9	1.0	-0.5	0.1	1.1
Intermittent access total infusions	0.7	0.8	2.1	0.8	1.2	-0.3	0.2	1.4
Intermittent access day 1 locomotion	0.9	0.9	2.8	-0.9	0.1	0.7	1.7	0.6
Intermittent access day 15 total locomotion	1.0	1.1	3.5	-1.0	0.3	0.2	1.9	0.9
Intermittent access total locomotion	0.8	0.9	2.8	-0.8	0.3	0.3	1.7	0.9
Intermittent access standard deviation	0.7	0.8	1.6	0.6	1.1	-0.6	0.5	1.3
Cocaine induced anxiety	2.3	2.7	4.3	1.7	2.0	-1.3	0.7	2.1
Post-drug Anxiety	2.4	2.6	4.2	2.0	1.7	-1.8	-0.9	1.4
Baseline Anxiety	0.9	1.0	3.5	-0.1	-0.7	-0.1	-1.9	-0.9
Lifetime Intake	1.2	1.3	3.3	0.9	1.5	-0.3	0.5	1.8
Incentive Sensitization - Responses	0.8	0.8	2.6	-0.7	0.5	0.3	1.6	0.9
Incentive Sensitization - Breakpoint	0.9	0.9	2.7	-0.6	0.6	0.3	1.6	1.1
Progressive ratio test 1 active lever presses	2.0	2.0	3.5	1.6	1.4	-1.9	-0.6	1.4
Progressive ratio test 1 breakpoint	2.5	2.6	4.4	1.9	1.5	-2.1	-0.8	1.5
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.1	0.6	0.6	-1.0	-0.2	0.8
Progressive ratio test 2 active lever presses	0.9	1.0	2.0	0.2	1.0	-0.3	1.4	1.4
Progressive ratio test 2 breakpoint	0.9	0.9	2.0	0.1	0.9	-0.4	1.4	1.3
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.3	0.2	0.8	-0.2	0.8	1.1
Total sessions with >9 infusions	1.7	1.9	3.0	1.7	1.6	-1.3	-0.5	1.4
Short access day 1 total inactive lever presses	0.7	0.8	1.5	-1.2	-1.1	0.9	-0.1	-0.7
Short access day 10 total inactive lever presses	2.8	3.1	4.9	-1.8	-2.2	1.2	-1.0	-2.2
Short access day 1 total infusions	0.8	0.9	1.7	1.0	1.2	-0.6	0.1	1.3
Short access day 10 total infusions	0.3	0.4	1.0	0.1	0.7	0.3	0.6	1.0
Short access total infusions	1.6	1.7	4.1	1.1	1.7	-0.2	0.8	2.0
Short access day 1 locomotion	0.8	0.8	2.6	-0.6	0.4	0.4	1.6	0.9
Short access day 10 total locomotion	0.8	0.9	1.8	-1.3	-0.6	1.1	1.1	-0.2
Short access total locomotion	1.1	1.1	2.6	0.3	1.2	-0.1	1.1	1.6
Compulsive drug intake	2.5	2.5	5.6	-1.9	-1.1	2.4	1.4	-0.6
One hour access (0.3 mA shock)	1.4	1.6	3.8	-0.6	0.8	0.4	1.9	1.7
One hour access (shock baseline)	1.8	2.1	3.6	1.2	1.7	-1.5	-0.1	1.9
Number of responses in last shaping day	1.6	1.6	3.2	-1.0	-1.6	0.9	-0.8	-1.8
Context. condit. distance diff. score	1.5	1.9	6.0	0.6	-0.5	-1.4	-2.4	-0.9
Locomotion velocity, session 1	1.0	1.1	1.5	-1.1	-1.2	1.0	0.8	-1.2
Locomotion distance, session 1	0.1	0.2	0.5	0.5	0.2	-0.7	-0.0	0.0
Locomotion velocity, session 2	0.3	0.3	0.6	0.3	0.5	-0.6	0.7	0.5
Locomotion distance, session 2	0.6	0.8	2.6	-1.0	-0.6	0.2	1.6	-0.2
Locomotion velocity, session 3	0.1	0.1	0.2	0.3	0.4	-0.1	0.1	0.5
Locomotion distance, session 3	0.1	0.1	0.2	0.4	0.1	0.2	-0.3	-0.1
Stereotopy head waving bouts, day 3	1.1	1.4	1.9	1.0	1.4	-1.3	-0.6	1.4
Stereotopy head waving duration, day 3	1.4	1.7	2.7	1.1	1.6	-1.4	-0.3	1.6
Locomotion velocity, session 7	0.5	0.6	1.4	1.0	0.5	-1.2	-0.5	0.3
Locomotion distance, session 7	0.3	0.4	1.1	0.8	-0.0	-1.1	-0.4	-0.3
Stereotopy head waving bouts, day 7	0.4	0.5	1.5	-0.7	-0.4	1.2	0.5	-0.2
Stereotopy head waving duration, day 7	0.8	0.9	2.5	-0.9	-0.3	1.6	1.1	0.1
Locomotion velocity, session 8	0.1	0.1	0.3	0.1	-0.4	-0.1	-0.3	-0.6
Locomotion distance, session 8	0.2	0.3	0.9	-0.1	-0.4	-0.9	-0.3	-0.4
Degree of sensitization distance	0.3	0.3	0.7	-0.4	-0.7	-0.1	-0.0	-0.8
Degree of sensitization stereotypy	0.7	0.8	2.5	-0.8	-0.2	1.6	0.9	0.1
Condit. Reinf. active minus inactive responses	0.8	0.9	1.7	-1.2	-0.7	0.8	1.3	-0.4
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.3	-1.1	-0.8	0.9	0.9	-0.4
Condit. Reinf. active responses	1.2	1.5	2.8	-1.5	-0.9	1.3	1.7	-0.4
Condit. Reinf. inactive responses	0.5	0.5	1.1	-0.7	-0.5	0.9	1.0	-0.3
Incentive salience index mean	1.5	1.9	3.6	-1.9	-1.0	1.1	1.8	-0.4
Condit. Reinf. lever presses	1.1	1.5	3.6	-1.9	-1.2	0.6	1.3	-0.6
Time in familiar zone, hab. session 1	1.3	1.2	3.2	1.3	0.4	-1.0	-1.8	0.1
Time in novel zone, hab. session 1	3.2	3.1	5.5	-2.1	-1.1	1.9	2.3	-0.6
Total zone transitions, hab. session 1	1.1	1.5	2.1	1.3	1.4	-1.2	-0.6	1.4
Total locomotion distance, hab. session 1	0.2	0.3	0.7	0.4	0.5	-0.8	-0.6	0.5
Locomotion velocity, hab. session 1	0.3	0.5	0.6	0.6	0.8	-0.8	-0.4	0.8
Time in familiar zone, hab. session 2	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.4	-0.1
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.3	-0.1	0.5	0.7	0.0
Total zone transitions, hab. session 2	3.7	4.8	8.0	2.7	2.2	-2.8	-1.0	1.8
Total locomotion distance, hab. session 2	2.9	3.8	5.7	2.3	1.9	-2.4	-1.2	1.7
Locomotion velocity, hab. session 2	2.9	3.9	5.6	2.3	2.0	-2.4	-1.0	1.9
Novel to familiar place preference ratio	0.9	1.0	2.2	-1.5	-0.7	1.0	1.0	-0.3
Novelty place preference	0.6	0.6	1.5	-1.2	-0.7	0.8	0.6	-0.4
Time in novel zone, NPP test	0.9	0.9	2.0	-1.4	-0.9	0.9	0.6	-0.6
Total zone transitions, NPP test	1.4	2.0	3.2	1.8	1.5	-1.6	-0.6	1.4
Total locomotion distance, NPP test	1.1	1.5	2.1	1.5	1.3	-1.4	-0.6	1.2
Locomotion velocity, NPP test	1.1	1.6	2.2	1.5	1.4	-1.4	-0.5	1.3
Pavlov. Cond. lever latency	2.3	2.9	4.9	2.2	1.9	-1.8	-0.9	1.4
Pavlov. Cond. magazine entry latency	0.0	0.1	0.2	-0.2	0.0	-0.0	0.4	0.2
Pavlov. Cond. change in total contacts	1.5	1.6	3.1	-1.8	-1.2	1.1	1.3	-0.7
Pavlov. Cond. index score	1.1	1.4	2.3	-1.5	-1.3	1.2	0.8	-1.0
Pavlov. Cond. latency score	1.1	1.4	2.3	-1.5	-1.3	1.3	0.8	-1.0
Pavlov. Cond. lever contacts	1.2	1.5	2.5	-1.6	-1.4	1.2	0.6	-1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.3	-0.1	0.0	-0.5	-0.4
Pavlov. Cond. intertrial magazine entries	2.0	2.3	3.5	1.8	1.9	-1.2	0.5	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.0	-1.4	-1.1	1.1	0.8	-0.8
Pavlov. Cond. response bias	0.6	0.7	1.6	-1.3	-1.0	0.6	0.5	-0.6
Bone: apparent density	0.2	0.4	0.7	0.7	0.4	-0.8	-0.6	0.3
Bone surface	1.1	1.8	3.3	-1.8	-1.5	1.3	0.9	-1.1
Bone volume	0.0	0.1	0.1	-0.3	-0.3	0.3	0.0	-0.1
Bone: connectivity density	1.1	1.8	2.5	-1.6	-1.3	1.6	1.0	-1.0
Bone: cortical apparent density	4.2	5.4	10.7	2.6	2.2	-3.3	-1.2	1.8
Bone: cortical area	0.4	0.5	1.1	-0.7	0.3	0.0	1.0	1.0
Bone: cortical porosity	0.3	0.3	0.9	-0.6	-0.4	1.0	-0.0	-0.2
Bone: cortical porosity	0.7	0.8	1.7	-0.9	-0.9	1.3	0.1	-0.7
Bone: cortical thickness	0.3	0.4	1.2	0.2	0.7	-0.6	-0.3	1.1
Bone: cortical thickness	0.1	0.2	0.3	-0.5	-0.5	-0.3	-0.3	-0.2
Bone: cortical tissue density	4.0	5.2	10.3	2.6	2.1	-3.2	-1.2	1.8
Bone: elastic displacement	0.4	0.4	1.3	0.4	-0.2	-0.7	-1.1	-0.5
Bone: elastic work	0.6	0.8	2.0	0.8	0.5	-0.9	-1.4	0.4
Bone: endosteal estimation	0.6	1.2	2.0	-1.4	-1.4	0.5	0.6	-1.2
Bone: endosteal perimeter	0.6	1.1	2.8	-1.3	-0.7	0.9	1.7	-0.1
Bone: final force	0.5	0.7	1.8	0.2	0.9	-1.0	0.1	1.4
Bone: final moment	0.2	0.3	0.7	-0.6	0.3	-0.3	0.4	0.8
Bone: marrow area	0.6	1.2	2.1	-1.4	-1.4	0.5	0.6	-1.2
Bone: maximum diameter	0.4	0.8	2.3	-0.7	0.3	0.5	1.5	0.9
Bone: maximum force	0.1	0.2	0.5	-0.4	0.2	-0.4	0.5	0.7
Bone: maximum moment	0.3	0.5	1.5	-1.2	-0.6	0.3	0.7	0.1
Bone: minimum diameter	0.4	0.7	1.5	-1.0	-0.3	1.2	0.8	0.2
Bone: periosteal estimation	0.4	0.8	2.0	-1.4	-0.8	0.5	1.1	-0.2
Bone: periosteal perimeter	0.6	1.1	3.3	-1.2	-0.3	0.6	1.8	0.4
Bone: post-yield work	2.2	3.1	6.2	-2.5	-1.6	1.2	2.0	-1.0
Bone: stiffness	0.1	0.2	0.4	-0.4	0.2	-0.6	0.3	0.6
Bone: tissue strength	1.3	1.2	3.1	-1.3	0.0	0.9	1.8	0.8
Bone: trabecular number	0.1	0.2	0.6	0.4	0.1	-0.3	-0.8	0.1
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	-0.3	-0.0	-0.2	-0.3
Bone: trabecular thickness	0.6	0.8	1.1	1.0	1.0	-0.8	-0.2	1.0
Bone: trabecular tissue density	8.3	11.7	24.4	3.9	3.0	-4.9	-1.9	2.5
Breakpoint value in progressive ratio session	0.4	0.5	1.1	-0.2	-0.8	-0.1	-0.7	-1.1
Distance traveled before self-admin	0.4	0.4	0.6	-0.6	-0.7	0.3	-0.8	-0.7
Distance traveled after self-admin	0.4	0.4	0.8	-0.9	-0.5	0.8	0.7	-0.2
Delta time in closed arm before/after self-admin	1.3	1.2	2.9	-0.6	-1.3	1.1	-0.1	-1.7
Delta time in open arm before/after self-admin	1.6	1.6	3.8	-0.4	1.0	0.1	1.9	1.7
Diff in mean of infusions in LGA sessions	0.7	0.8	1.7	-0.1	-1.0	0.2	-1.1	-1.3
Extinction: sum of active levers before priming	1.5	1.5	5.0	1.0	-0.1	-1.0	-2.2	-0.7
Active lever presses in extinction session 6	2.1	2.0	3.5	-1.4	-1.9	0.8	-0.9	-1.8
Delta distance traveled before/after self-admin	0.7	0.7	2.2	-0.5	-0.0	1.0	1.5	0.2
Delta ambulatory time before/after self-admin	0.6	0.6	1.9	0.1	0.6	0.5	1.4	0.8
Time in closed arm before self-admin	1.4	1.6	3.7	0.4	1.5	-0.6	1.3	1.9
Time in closed arm after self-admin	0.1	0.1	0.2	0.3	0.1	0.5	0.4	-0.1
Time in open arm before self-admin	1.6	1.7	4.0	-0.4	-1.5	0.8	-1.1	-2.0
Time in open arm after self-admin	0.5	0.5	1.0	-1.0	-0.3	0.9	0.8	0.2
Sum of active levers in priming session hrs 5-6	2.6	2.6	5.8	-0.1	-1.5	-0.8	-2.4	-2.0
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.3	-1.1	-0.9	1.5	0.6	-0.7
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.1	0.2	0.3	0.5	0.4
Time to tail flick, test, before self-admin	0.4	0.4	0.6	0.6	0.7	-0.0	-0.6	0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.0	-0.3	-0.4	-0.6	-0.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	2.5	0.8	0.7	-1.6	-0.4	0.6
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.6	-0.6	0.2	0.7	-0.4
Ambulatory time before self-admin	1.0	1.0	2.8	-0.5	-0.9	0.2	-1.7	-1.1
Ambulatory time after self-admin	0.5	0.6	1.1	-1.1	-0.5	1.0	0.6	-0.2
Total heroin consumption	0.6	0.7	2.0	0.9	-0.0	-1.4	-0.7	-0.5
Area under the delay curve	1.8	1.9	5.3	2.3	1.5	-0.4	-1.0	0.8
Delay disc. indifference point, 0s delay	3.2	3.5	7.4	2.6	1.0	-1.5	-2.7	-0.0
Delay disc. indifference point, 16s delay	0.6	0.6	2.4	-0.0	0.1	1.5	0.8	0.0
Delay disc. indifference point, 2s delay	1.7	1.9	4.6	2.0	0.7	-0.7	-2.1	-0.1
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.6	0.7	0.3	0.5	0.5
Delay disc. indifference point, 4s delay	4.7	4.9	10.4	3.2	2.2	-2.0	-2.0	1.3
Delay disc. indifference point, 8s delay	1.7	1.8	4.1	2.0	1.5	-1.1	-0.8	0.8
Delay discount exponential model param	1.7	1.8	4.9	-2.2	-1.5	0.4	1.0	-0.8
Delay discount hyperbolic model param	2.1	2.3	6.0	-2.4	-1.6	0.6	1.2	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.4	0.7	0.4	0.7	0.2	0.7	0.8
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.6	0.1	-0.8	-0.9	-0.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.0	0.9	1.0	0.1	-0.6	1.0
Bouts of movement, locomotor time 1	2.2	2.4	4.8	-0.7	-1.8	1.4	-1.3	-2.2
Total resting periods, locomotor time 1	2.0	2.3	4.5	-0.5	-1.7	1.3	-1.3	-2.1
Rest time, locomotor task time 1	0.6	0.6	1.2	-0.3	-0.9	-0.1	-1.0	-1.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.3	0.2	-0.5	0.4	0.2
Vertical activity count, locomotor time 1	0.6	0.6	1.2	0.8	1.0	-0.5	-0.1	1.1
Time >=10cm from walls, locomotor time 2	1.6	1.7	4.1	0.9	0.9	-1.3	-2.0	0.8
Bouts of movement, locomotor time 2	0.5	0.5	1.3	-0.9	-0.6	1.1	0.0	-0.4
Total resting periods, locomotor time 2	0.4	0.4	1.2	-0.7	-0.4	1.1	0.1	-0.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	0.0	0.2	-0.2	-0.2
Distance moved, locomotor task time 2	0.3	0.4	1.2	-0.0	-0.4	-1.1	-0.6	-0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.1	-0.1	-0.6	-0.8	0.1
Weight adjusted by age	0.2	0.3	0.4	0.2	0.6	0.5	0.4	0.7
Seeking ratio, delayed vs. immediate footshock	2.8	3.2	7.3	-0.7	-2.1	0.6	-1.7	-2.7
Locomotion in novel chamber	0.9	1.1	2.2	-1.5	-1.0	1.3	0.5	-0.6
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	-0.1	0.6	0.1	1.0	1.0
Progressive ratio	0.5	0.5	0.7	0.8	0.8	-0.6	0.6	0.8
Food seeking constrained by brief footshock	1.5	1.8	5.7	1.4	0.5	-2.4	-1.2	0.1
Seeking ratio, punishment vs. effort	0.4	0.5	1.2	0.0	-0.5	-0.8	-1.1	-0.6
Run reversals in cocaine runway, females	0.8	0.8	1.5	-0.3	-0.8	0.1	-1.2	-1.2
Run reversals in cocaine runway, males	0.6	0.6	0.8	-0.7	-0.9	0.9	0.7	-0.7
Latency to leave start box in cocaine runway	0.4	0.4	1.5	-0.0	-0.5	-1.2	-0.1	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	-0.1	-0.6	0.6	-0.1
Latency to leave start box in cocaine runway, M	0.7	0.7	1.7	0.3	-0.6	-0.8	-1.3	-0.8
Cd content in liver	4.3	4.7	7.7	-2.4	-2.8	1.6	0.2	-2.7
Co content in liver	2.2	2.6	5.1	-1.2	-2.1	0.1	-1.5	-2.3
Cu content in liver	0.0	0.0	0.1	0.0	0.2	-0.2	-0.0	0.3
Fe content in liver	1.3	1.5	2.6	-1.6	-1.5	1.0	0.6	-1.1
K content in liver	0.9	0.9	1.6	1.0	0.9	-1.3	-0.7	0.9
Mg content in liver	2.2	2.3	5.1	0.4	1.7	0.0	1.8	2.3
Mn content in liver	0.1	0.1	0.2	-0.5	-0.2	0.1	0.2	-0.1
Na content in liver	1.2	1.3	4.3	0.5	0.4	-2.1	-1.1	0.6
Rb content in liver	0.4	0.5	0.9	0.9	0.7	-0.8	-0.6	0.5
Se content in liver	1.1	1.3	1.9	-1.3	-1.4	1.1	0.4	-1.2
Sr content in liver	1.3	1.2	2.2	-1.2	-1.5	0.2	0.4	-1.5
Zn content in liver	0.8	0.9	3.0	-0.7	0.1	0.8	1.7	0.6