Hub : Genes

Ccnyl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression ENSRNOG00000023807 0.46 0.21 3.4e-03 -0 0.03 0.01 -0 4.1e-01 2.3e-03 4.1e-02 9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail2.06.66.6-2.6
BMI without tail4.49.39.3-3.0
Body weight0.10.40.4-0.6
Epididymis fat weight1.22.92.91.7
Glucose0.40.70.7-0.8
Heart weight18.626.626.65.2
Left kidney weight0.00.10.10.3
Right kidney weight0.41.31.31.1
Tail length0.00.10.10.4
Length with tail2.38.38.32.9
Length without tail2.75.95.92.4
Liver weight, left0.91.51.5-1.2
Liver weight, right3.25.45.4-2.3
Parametrial fat weight0.10.20.20.4
Retroperitoneal fat weight0.20.60.60.8
Intraocular pressure1.11.61.61.2
Extensor digitorum longus weight2.510.210.2-3.2
Soleus weight6.318.418.4-4.3
Tibialis anterior weight2.910.210.2-3.2
Tibia length0.30.90.91.0
Number of licking bursts1.31.61.61.3
Food consumed during 24 hour testing period0.91.11.1-1.1
Times rat made contact with spout0.10.10.10.3
Mean time between licks in bursts0.00.00.0-0.0
Mean num. licks in bursts0.70.90.9-0.9
Std. dev. time between licks in bursts0.60.70.7-0.8
Water consumed over 24 hours1.72.02.0-1.4
Indifference point 0 sec0.61.01.01.0
Indifference point AUC15.518.218.2-4.3
Indifference point function ln k6.99.89.83.1
Indifference point function log k6.99.89.83.1
Delay discounting total patch changes 0 sec1.52.52.51.6
Delay discounting total patch changes 12 sec6.68.88.8-3.0
Delay discounting total patch changes 18 sec1.82.42.4-1.5
Delay discounting total patch changes 24 sec3.84.84.8-2.2
Delay discounting total patch changes 6 sec2.94.54.5-2.1
Delay discounting time to switch 0 sec0.40.50.50.7
Delay discounting water rate 0 sec0.10.10.1-0.4
Delay discounting water rate 12 sec2.43.63.61.9
Delay discounting water rate 18 sec6.28.28.22.9
Delay discounting water rate 24 sec12.817.717.74.2
Delay discounting water rate 6 sec0.20.30.30.6
Locomotor activity2.54.04.02.0
Locomotor testing distance9.115.115.13.9
Locomotor testing rearing4.97.87.82.8
Light reinforcement 11.22.12.1-1.5
Light reinforcement 20.30.40.40.6
Reaction time number correct1.82.62.61.6
Reaction time mean minus median5.06.56.5-2.5
Reaction time mean minus median AUC3.74.74.7-2.2
Reaction time num false alarms0.20.30.3-0.5
Reaction time num false alarms AUC0.00.00.0-0.2
Reaction time trials correct on left1.82.62.61.6
Reaction time trials on left2.02.82.81.7
Reaction time mean0.30.40.4-0.6
Reaction time mean AUC0.30.40.4-0.6
Median of all reaction times0.00.00.00.2
Reaction time omissions2.12.82.81.7
Reaction time false alarm rate0.00.00.0-0.1
Reaction time premature initiation rate0.00.00.0-0.2
Reaction time premature initiations0.20.30.30.6
Std. dev. reaction times1.52.02.0-1.4
Reaction time trials completed2.02.82.81.7
Reaction time trials AUC1.42.12.11.4
Social response proportion0.30.40.4-0.6
Social responses1.41.81.8-1.3
Social time0.20.20.2-0.4
Conditioned locomotion1.21.51.5-1.2
Cocaine response after cond. corrected0.30.40.4-0.6
Cocaine response after cond. not corrected0.80.90.91.0
Cocaine response before conditioning7.69.39.33.1
Saline control response3.24.24.2-2.1
Condit. Reinf. active minus inactive responses0.00.00.00.1
Condit. Reinf. active-inactive response ratio0.50.50.50.7
Condit. Reinf. active responses0.10.20.2-0.4
Condit. Reinf. inactive responses0.30.40.4-0.6
Condit. Reinf. lever presses0.10.10.1-0.3
Condit. Reinf. lever reinforcers received0.00.00.0-0.1
Pavlov. Cond. lever latency0.81.11.1-1.0
Pavlov. Cond. magazine entry latency0.10.10.1-0.3
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.00.00.00.2
Pavlov. Cond. latency score0.00.00.00.2
Pavlov. Cond. lever contacts0.91.21.21.1
Pavlov. Cond. magazine entry number1.31.61.61.3
Pavlov. Cond. intertrial magazine entries0.30.40.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1
Pavlov. Cond. response bias0.30.40.40.7
Conditioned reinforcement - actives0.80.80.80.9
Conditioned reinforcement - inactives0.40.40.40.6
Conditioned locomotion11.013.213.2-3.6
Intermittent access intake day 1-15 change0.10.10.10.3
Intermittent access intake escalation0.10.10.10.3
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses1.71.81.81.3
Intermitt. access day 15 inactive lever presses1.11.21.21.1
Intermitt. access escalation Index28.725.725.7-5.1
Intermittent access day 1 total infusions1.51.71.7-1.3
Intermittent access day 15 total infusions1.01.11.1-1.0
Intermittent access terminal intake (last 3 days)0.00.10.1-0.2
Intermittent access total infusions1.82.02.0-1.4
Intermittent access day 1 locomotion2.22.32.3-1.5
Intermittent access day 15 total locomotion1.31.41.4-1.2
Intermittent access total locomotion7.18.08.0-2.8
Intermittent access standard deviation1.81.91.91.4
Cocaine induced anxiety2.32.72.71.6
Post-drug Anxiety2.42.62.61.6
Baseline Anxiety2.42.52.51.6
Lifetime Intake0.10.20.2-0.4
Incentive Sensitization - Responses4.34.24.2-2.1
Incentive Sensitization - Breakpoint2.62.62.6-1.6
Progressive ratio test 1 active lever presses10.010.310.3-3.2
Progressive ratio test 1 breakpoint9.810.210.2-3.2
Progressive ratio test 1 inactive lever presses0.20.30.3-0.5
Progressive ratio test 2 active lever presses0.70.70.7-0.9
Progressive ratio test 2 breakpoint0.30.30.3-0.5
Progressive ratio test 2 inactive lever presses1.41.61.6-1.3
Total sessions with >9 infusions3.33.63.61.9
Short access day 1 total inactive lever presses3.53.93.9-2.0
Short access day 10 total inactive lever presses2.62.82.81.7
Short access day 1 total infusions0.00.00.0-0.1
Short access day 10 total infusions0.30.30.3-0.5
Short access total infusions0.50.60.60.8
Short access day 1 locomotion0.10.10.1-0.3
Short access day 10 total locomotion0.80.90.91.0
Short access total locomotion1.31.41.4-1.2
Compulsive drug intake0.00.00.00.0
One hour access (0.3 mA shock)1.92.22.2-1.5
One hour access (shock baseline)0.10.10.1-0.3
Number of responses in last shaping day8.28.38.32.9
Context. condit. distance diff. score5.76.96.92.6
Locomotion velocity, session 10.20.20.20.4
Locomotion distance, session 11.21.61.6-1.3
Locomotion velocity, session 25.76.76.7-2.6
Locomotion distance, session 22.73.93.9-2.0
Locomotion velocity, session 30.00.10.1-0.2
Locomotion distance, session 30.30.30.30.5
Stereotopy head waving bouts, day 30.80.90.9-1.0
Stereotopy head waving duration, day 32.73.33.3-1.8
Locomotion velocity, session 70.20.20.2-0.4
Locomotion distance, session 72.12.72.7-1.6
Stereotopy head waving bouts, day 71.11.31.31.1
Stereotopy head waving duration, day 70.60.70.70.8
Locomotion velocity, session 80.20.30.30.5
Locomotion distance, session 81.52.22.21.5
Degree of sensitization distance3.63.63.6-1.9
Degree of sensitization stereotypy1.31.41.41.2
Condit. Reinf. active minus inactive responses0.20.20.20.5
Condit. Reinf. active-inactive response ratio1.51.61.61.3
Condit. Reinf. active responses0.70.80.8-0.9
Condit. Reinf. inactive responses4.95.85.8-2.4
Incentive salience index mean0.40.50.5-0.7
Condit. Reinf. lever presses5.98.08.0-2.8
Time in familiar zone, hab. session 10.00.00.00.1
Time in novel zone, hab. session 10.30.30.30.6
Total zone transitions, hab. session 10.00.00.0-0.0
Total locomotion distance, hab. session 10.00.00.00.1
Locomotion velocity, hab. session 10.00.00.00.1
Time in familiar zone, hab. session 22.93.13.1-1.8
Time in novel zone, hab. session 26.16.16.12.5
Total zone transitions, hab. session 22.02.62.61.6
Total locomotion distance, hab. session 22.02.62.61.6
Locomotion velocity, hab. session 21.42.02.01.4
Novel to familiar place preference ratio0.00.00.00.0
Novelty place preference0.60.70.7-0.8
Time in novel zone, NPP test0.20.30.3-0.5
Total zone transitions, NPP test0.20.30.3-0.5
Total locomotion distance, NPP test0.00.10.1-0.2
Locomotion velocity, NPP test0.30.40.4-0.6
Pavlov. Cond. lever latency0.81.11.11.0
Pavlov. Cond. magazine entry latency0.00.00.00.2
Pavlov. Cond. change in total contacts1.01.11.1-1.0
Pavlov. Cond. index score1.11.41.4-1.2
Pavlov. Cond. latency score1.01.31.3-1.1
Pavlov. Cond. lever contacts4.04.74.7-2.2
Pavlov. Cond. magazine entry number0.40.50.5-0.7
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.31.3-1.1
Pavlov. Cond. response bias0.20.30.3-0.5
Bone: apparent density0.00.10.1-0.3
Bone surface2.44.34.3-2.1
Bone volume0.10.20.2-0.4
Bone: connectivity density1.82.82.8-1.7
Bone: cortical apparent density6.58.48.4-2.9
Bone: cortical area0.20.30.3-0.5
Bone: cortical porosity9.910.710.73.3
Bone: cortical porosity9.510.310.33.2
Bone: cortical thickness0.71.21.2-1.1
Bone: cortical thickness1.61.91.9-1.4
Bone: cortical tissue density6.28.08.0-2.8
Bone: elastic displacement0.10.10.1-0.3
Bone: elastic work0.50.70.70.8
Bone: endosteal estimation0.00.00.00.0
Bone: endosteal perimeter1.83.63.61.9
Bone: final force0.20.40.40.6
Bone: final moment0.91.41.41.2
Bone: marrow area0.00.00.00.0
Bone: maximum diameter0.30.50.50.7
Bone: maximum force0.20.30.30.6
Bone: maximum moment0.81.41.41.2
Bone: minimum diameter0.50.90.90.9
Bone: periosteal estimation0.20.30.30.6
Bone: periosteal perimeter0.61.01.01.0
Bone: post-yield work3.24.34.32.1
Bone: stiffness0.00.00.00.2
Bone: tissue strength6.96.76.72.6
Bone: trabecular number0.71.11.1-1.0
Bone: trabecular spacing2.32.92.91.7
Bone: trabecular thickness0.00.00.0-0.2
Bone: trabecular tissue density1.11.61.61.2
Breakpoint value in progressive ratio session4.75.35.3-2.3
Distance traveled before self-admin2.52.72.7-1.7
Distance traveled after self-admin4.14.54.5-2.1
Delta time in closed arm before/after self-admin0.70.60.6-0.8
Delta time in open arm before/after self-admin0.20.20.2-0.4
Diff in mean of infusions in LGA sessions0.10.10.1-0.3
Extinction: sum of active levers before priming4.34.34.3-2.1
Active lever presses in extinction session 61.91.81.8-1.3
Delta distance traveled before/after self-admin0.60.70.7-0.8
Delta ambulatory time before/after self-admin0.20.30.3-0.5
Time in closed arm before self-admin2.02.32.31.5
Time in closed arm after self-admin1.61.71.71.3
Time in open arm before self-admin0.50.50.5-0.7
Time in open arm after self-admin2.52.82.8-1.7
Sum of active levers in priming session hrs 5-66.05.95.9-2.4
Time to tail flick, vehicle, before self-admin1.51.51.5-1.2
Time to tail flick, vehicle, after self-admin6.87.27.22.7
Time to tail flick, test, before self-admin11.511.311.33.4
Time to tail flick, test, after self-admin4.34.44.4-2.1
Delta time to tail flick, vehicle, before/after SA4.74.64.62.1
Delta time to tail flick, test, before/after SA18.916.916.9-4.1
Ambulatory time before self-admin5.86.16.1-2.5
Ambulatory time after self-admin7.68.48.4-2.9
Total heroin consumption0.10.10.10.4
Area under the delay curve0.40.50.5-0.7
Delay disc. indifference point, 0s delay1.31.41.4-1.2
Delay disc. indifference point, 16s delay0.50.50.5-0.7
Delay disc. indifference point, 2s delay0.10.10.1-0.4
Delay disc. indifference point, 24s delay0.10.10.1-0.3
Delay disc. indifference point, 4s delay1.21.31.3-1.1
Delay disc. indifference point, 8s delay0.00.00.0-0.2
Delay discount exponential model param0.40.40.40.7
Delay discount hyperbolic model param0.40.40.40.6
Fecal boli incidents, locomotor time 10.50.50.50.7
Change in fecal boli incidents, locomotor task0.30.30.30.5
Time >=10cm from walls, locomotor time 10.00.00.00.1
Bouts of movement, locomotor time 10.00.00.00.1
Total resting periods, locomotor time 10.00.00.00.1
Rest time, locomotor task time 10.00.00.00.1
Distance moved, locomotor task time 11.11.21.2-1.1
Vertical activity count, locomotor time 10.30.30.3-0.5
Time >=10cm from walls, locomotor time 20.20.20.20.5
Bouts of movement, locomotor time 20.00.00.00.1
Total resting periods, locomotor time 20.00.00.00.2
Rest time, locomotor task time 20.30.30.30.5
Distance moved, locomotor task time 20.60.70.7-0.8
Vertical activity count, locomotor time 20.70.70.7-0.8
Weight adjusted by age5.76.46.4-2.5
Seeking ratio, delayed vs. immediate footshock3.03.43.4-1.8
Locomotion in novel chamber13.416.616.6-4.1
Locomotion in novel chamber post-restriction3.44.14.1-2.0
Progressive ratio0.00.00.00.2
Food seeking constrained by brief footshock4.65.65.6-2.4
Seeking ratio, punishment vs. effort2.22.72.7-1.6
Run reversals in cocaine runway, females5.35.25.22.3
Run reversals in cocaine runway, males3.13.03.01.7
Latency to leave start box in cocaine runway0.00.00.0-0.0
Latency to leave start box in cocaine runway, F0.70.80.80.9
Latency to leave start box in cocaine runway, M3.13.03.0-1.7
Cd content in liver3.63.93.92.0
Co content in liver2.73.23.21.8
Cu content in liver0.60.70.70.8
Fe content in liver2.32.72.71.7
K content in liver11.911.911.9-3.4
Mg content in liver3.03.13.1-1.7
Mn content in liver0.00.00.0-0.2
Na content in liver17.618.718.7-4.3
Rb content in liver0.30.40.4-0.6
Se content in liver2.83.43.41.8
Sr content in liver1.71.61.6-1.3
Zn content in liver0.00.00.0-0.1