Cops4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000023650	0.1	0.05	3.5e-04	0.06	0.02	0.03	0.04	5.9e-04	1.9e-02	1.4e-02	3.3e-03
2	Brain	gene expression	ENSRNOG00000023650	0.15	0.06	6.5e-13	0.1	0.14	0.15	0.14	8.2e-10	1.1e-12	1.9e-13	5.6e-13
3	Brain	intron excision ratio	chr14:9096935:9108677	0.07	0.04	1.9e-04	0.01	0.03	0	0.01	4.9e-02	2.0e-03	1.4e-01	6.8e-02
4	LHb	gene expression	ENSRNOG00000023650	0.12	0.07	4.8e-03	0.08	0.09	0.1	0.06	6.1e-03	4.3e-03	2.6e-03	1.2e-02
5	Liver	gene expression	ENSRNOG00000023650	0.33	0.09	0.0e+00	0.37	0.39	0.38	0.38	5.6e-43	1.6e-45	8.8e-45	3.2e-45

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.8	5.8	13.2	-2.3	-0.8	2.5	-1.9	3.6
BMI without tail	0.8	1.6	4.8	-0.9	0.2	1.6	-0.4	2.2
Body weight	1.4	6.1	10.5	-3.2	-2.7	1.9	-1.1	2.8
Epididymis fat weight	0.2	0.5	1.4	-1.2	-0.5	0.1	-0.3	1.0
Glucose	0.3	0.4	0.7	-0.7	-0.7	-0.6	-0.8	0.3
Heart weight	2.5	3.6	6.3	-1.9	-1.6	2.5	-2.1	1.2
Left kidney weight	1.7	4.8	8.2	-2.9	-2.2	2.0	-2.1	1.5
Right kidney weight	2.0	5.6	8.6	-2.9	-2.2	2.3	-2.4	1.8
Tail length	0.1	0.4	1.1	-0.3	-0.8	-0.1	1.0	-0.2
Length with tail	0.6	2.0	6.4	-1.9	-2.5	0.1	0.4	0.1
Length without tail	0.9	1.9	4.8	-2.0	-2.2	0.3	-0.7	0.4
Liver weight, left	2.5	4.0	7.9	-2.8	-2.4	1.0	-1.0	2.0
Liver weight, right	0.8	1.3	3.0	0.2	-0.6	-1.7	1.0	-1.5
Parametrial fat weight	0.8	1.5	3.1	-1.8	-1.6	-0.1	-1.3	0.6
Retroperitoneal fat weight	0.9	2.9	4.5	-2.1	-0.8	1.4	-1.8	2.0
Intraocular pressure	0.5	0.6	1.9	0.7	1.4	-0.7	-0.1	0.5
Extensor digitorum longus weight	4.2	17.0	26.6	-5.0	-5.2	3.2	-3.8	3.0
Soleus weight	3.3	9.7	15.9	-4.0	-3.7	2.0	-3.2	2.2
Tibialis anterior weight	1.2	4.1	10.3	-2.7	-3.2	0.9	-1.0	0.9
Tibia length	0.1	0.3	0.6	-0.2	-0.1	-0.8	0.8	0.5
Number of licking bursts	0.2	0.2	0.6	0.8	0.4	-0.4	0.3	-0.4
Food consumed during 24 hour testing period	1.0	1.2	2.1	1.4	1.0	-0.9	0.4	-1.4
Times rat made contact with spout	0.6	0.7	3.1	-0.4	0.1	-0.1	-1.8	-0.4
Mean time between licks in bursts	0.8	1.1	2.6	1.3	1.6	-0.9	0.4	-0.3
Mean num. licks in bursts	0.4	0.5	1.5	-0.9	-0.4	0.4	-1.2	0.1
Std. dev. time between licks in bursts	0.2	0.3	0.4	0.7	0.4	-0.6	-0.2	-0.6
Water consumed over 24 hours	1.3	1.5	3.2	1.3	1.3	-0.8	-0.1	-1.8
Indifference point 0 sec	0.4	0.6	1.9	-0.8	-0.7	0.4	-1.4	0.0
Indifference point AUC	0.9	1.1	2.5	-0.3	-0.6	-1.4	1.6	-0.6
Indifference point function ln k	1.5	2.1	6.6	-0.1	0.5	1.7	-2.6	0.9
Indifference point function log k	1.5	2.1	6.6	-0.1	0.5	1.7	-2.6	0.9
Delay discounting total patch changes 0 sec	0.6	1.0	3.1	-1.0	-0.9	0.5	-1.7	0.2
Delay discounting total patch changes 12 sec	0.1	0.1	0.3	-0.3	0.0	0.1	-0.2	0.5
Delay discounting total patch changes 18 sec	0.3	0.4	1.4	-0.7	-1.2	-0.3	0.0	-0.1
Delay discounting total patch changes 24 sec	1.7	2.2	4.4	-1.9	-2.1	1.0	-0.1	1.4
Delay discounting total patch changes 6 sec	0.6	1.0	2.1	-1.5	-1.1	0.7	-0.5	0.8
Delay discounting time to switch 0 sec	0.2	0.4	0.5	0.6	0.5	0.5	0.7	0.7
Delay discounting water rate 0 sec	0.4	0.6	1.5	-0.3	-0.2	-1.1	-0.3	-1.2
Delay discounting water rate 12 sec	2.0	3.0	7.3	-2.0	-2.7	1.5	-1.1	0.4
Delay discounting water rate 18 sec	2.5	3.3	4.6	-2.1	-2.0	1.4	-2.0	1.4
Delay discounting water rate 24 sec	2.4	3.3	5.7	-2.3	-2.4	1.4	-1.5	1.2
Delay discounting water rate 6 sec	0.3	0.5	1.1	-0.2	-1.0	-0.2	-0.5	-1.0
Locomotor activity	0.4	0.6	1.7	-0.2	-0.8	0.7	-1.3	-0.3
Locomotor testing distance	1.1	1.8	4.1	-0.7	-1.5	1.5	-2.0	0.1
Locomotor testing rearing	1.5	2.4	7.2	-0.8	-0.6	1.7	-2.7	0.9
Light reinforcement 1	1.0	1.9	3.9	-1.6	-2.0	0.5	-1.6	-0.0
Light reinforcement 2	0.5	0.6	1.9	-0.2	-0.9	-1.4	0.2	-0.6
Reaction time number correct	0.4	0.5	1.0	0.7	1.0	-0.6	0.4	-0.9
Reaction time mean minus median	0.2	0.3	0.5	-0.6	0.0	-0.6	-0.4	0.7
Reaction time mean minus median AUC	0.3	0.4	0.8	-0.4	0.5	-0.0	-0.7	0.9
Reaction time num false alarms	2.2	3.0	6.6	-1.5	-1.1	2.6	-1.6	1.5
Reaction time num false alarms AUC	1.7	2.4	5.7	-1.3	-0.9	2.4	-1.3	1.3
Reaction time trials correct on left	0.4	0.5	1.0	0.7	1.0	-0.6	0.4	-0.9
Reaction time trials on left	0.3	0.4	0.8	0.5	0.9	-0.5	0.3	-0.8
Reaction time mean	1.0	1.3	3.0	-1.7	-0.9	-0.6	-1.2	1.1
Reaction time mean AUC	0.7	0.9	2.2	-1.5	-0.8	-0.6	-0.8	0.8
Median of all reaction times	0.7	1.0	2.4	-1.5	-0.9	-0.8	-0.9	0.8
Reaction time omissions	0.9	1.2	2.3	-1.5	-1.0	0.9	0.2	1.3
Reaction time false alarm rate	2.1	3.0	6.0	-1.5	-1.2	2.4	-1.4	1.9
Reaction time premature initiation rate	0.4	0.5	2.0	0.8	0.3	-0.1	0.0	-1.4
Reaction time premature initiations	0.8	1.2	3.4	1.2	0.8	-0.5	0.4	-1.8
Std. dev. reaction times	0.9	1.2	2.6	-1.6	-1.0	-0.0	-1.0	1.2
Reaction time trials completed	0.3	0.4	0.8	0.5	0.9	-0.5	0.3	-0.8
Reaction time trials AUC	0.2	0.3	0.6	0.4	0.8	-0.4	0.3	-0.7
Social response proportion	1.3	1.4	3.3	1.2	1.8	1.1	-0.8	0.5
Social responses	1.4	1.8	4.3	1.8	2.1	0.3	-0.6	-1.0
Social time	4.6	6.0	9.9	2.5	2.0	-2.7	1.6	-3.2
Conditioned locomotion	0.9	1.0	3.5	-1.3	-1.9	-0.1	0.2	0.2
Cocaine response after cond. corrected	0.6	0.6	1.4	1.0	1.2	-0.3	0.8	0.0
Cocaine response after cond. not corrected	0.4	0.5	0.9	1.0	0.9	-0.2	0.7	0.1
Cocaine response before conditioning	0.0	0.0	0.2	0.1	-0.1	0.1	-0.4	0.0
Saline control response	0.5	0.7	1.4	-0.6	-1.1	-0.1	-1.2	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	-0.2	0.2	-0.4	-0.8	0.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.0	0.4	-0.9	-0.5	0.3
Condit. Reinf. active responses	0.3	0.4	1.0	0.0	0.8	-0.3	-1.0	-0.4
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.2	0.3	0.4	-0.3	-0.7
Condit. Reinf. lever presses	0.7	0.9	2.2	0.9	0.7	-1.0	0.4	-1.5
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	0.3	1.0	-0.3	-0.7	-0.6
Pavlov. Cond. lever latency	0.6	0.9	1.7	-1.0	-1.1	0.7	0.2	1.3
Pavlov. Cond. magazine entry latency	0.7	0.9	1.7	1.3	1.0	-0.7	0.8	-0.8
Pavlov. Cond. change in total contacts	1.6	2.2	3.4	1.8	1.4	-1.7	0.5	-1.6
Pavlov. Cond. index score	1.4	1.8	2.5	1.5	1.3	-1.5	0.6	-1.6
Pavlov. Cond. latency score	1.7	2.2	3.4	1.6	1.2	-1.6	0.8	-1.9
Pavlov. Cond. lever contacts	0.3	0.4	1.0	0.5	0.7	-0.5	-0.3	-1.0
Pavlov. Cond. magazine entry number	0.9	1.2	1.5	-1.2	-1.2	1.2	-0.5	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	0.2	-0.2	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.8	1.7	1.3	-1.4	0.6	-1.6
Pavlov. Cond. response bias	0.3	0.4	1.2	0.7	1.1	-0.6	-0.2	-0.4
Conditioned reinforcement - actives	1.6	1.6	4.1	2.0	1.4	-0.1	0.6	-1.1
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.4	0.1	-0.3	-0.0	-0.5
Conditioned locomotion	1.0	1.2	1.8	1.1	0.7	-1.3	1.0	-1.3
Intermittent access intake day 1-15 change	0.1	0.1	0.5	-0.2	-0.7	0.1	0.3	-0.3
Intermittent access intake escalation	0.2	0.2	0.8	-0.5	-0.9	0.3	-0.2	0.1
Intermittent access intake escalation 2	0.8	0.8	2.1	-1.3	-1.5	-0.1	-0.3	0.6
Intermitt. access day 1 inactive lever presses	1.4	1.5	3.1	-1.5	-1.7	1.2	-0.4	0.8
Intermitt. access day 15 inactive lever presses	1.1	1.2	3.8	-1.5	-1.9	0.0	0.5	-0.0
Intermitt. access escalation Index	0.3	0.2	0.7	0.4	0.8	0.5	0.1	-0.1
Intermittent access day 1 total infusions	1.0	1.1	2.0	1.3	1.2	-0.5	1.4	-0.3
Intermittent access day 15 total infusions	0.4	0.5	1.8	0.6	0.1	-0.1	1.4	0.0
Intermittent access terminal intake (last 3 days)	0.3	0.4	1.5	0.3	-0.4	0.0	1.2	-0.3
Intermittent access total infusions	0.7	0.8	2.3	1.0	0.6	-0.1	1.5	-0.2
Intermittent access day 1 locomotion	0.9	0.9	1.7	1.1	0.8	-0.9	1.3	-0.5
Intermittent access day 15 total locomotion	1.9	2.1	3.1	1.7	1.2	-1.4	1.8	-1.0
Intermittent access total locomotion	1.4	1.6	3.1	1.4	1.0	-1.2	1.7	-0.8
Intermittent access standard deviation	1.2	1.3	2.2	-1.3	-1.5	1.2	-0.6	1.0
Cocaine induced anxiety	0.5	0.6	1.3	-0.6	-0.6	-1.0	-1.1	-0.3
Post-drug Anxiety	0.3	0.4	1.1	-0.7	-1.0	-0.1	-0.5	-0.1
Baseline Anxiety	1.1	1.1	2.3	1.1	0.2	1.0	1.5	-1.1
Lifetime Intake	0.5	0.6	1.5	1.0	0.6	0.2	1.2	-0.0
Incentive Sensitization - Responses	4.2	4.2	6.5	2.5	1.9	-1.6	2.0	-2.1
Incentive Sensitization - Breakpoint	3.7	3.8	5.5	2.3	1.6	-1.5	2.0	-2.0
Progressive ratio test 1 active lever presses	0.9	0.9	2.0	1.4	1.0	-0.1	1.2	-0.5
Progressive ratio test 1 breakpoint	0.9	0.9	1.9	1.4	0.9	-0.2	1.1	-0.8
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.3	-1.3	-1.0	1.0	-0.4	1.5
Progressive ratio test 2 active lever presses	1.1	1.2	2.5	1.6	0.9	0.1	1.4	-0.8
Progressive ratio test 2 breakpoint	1.7	1.9	3.7	1.9	1.1	-0.2	1.8	-1.2
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.9	1.0	0.9	-0.3	0.8	-0.3
Total sessions with >9 infusions	0.1	0.1	0.1	0.3	0.2	-0.2	0.4	0.1
Short access day 1 total inactive lever presses	0.6	0.7	1.8	0.9	0.9	1.3	-0.3	0.1
Short access day 10 total inactive lever presses	1.7	1.9	3.2	-1.7	-1.4	0.7	-1.8	0.8
Short access day 1 total infusions	0.6	0.6	1.4	-0.4	0.1	1.1	-0.6	1.2
Short access day 10 total infusions	0.1	0.2	0.4	0.2	-0.0	0.6	0.6	0.1
Short access total infusions	0.2	0.2	0.3	0.6	0.3	0.5	0.5	0.1
Short access day 1 locomotion	1.6	1.7	2.5	-1.6	-1.4	0.9	-0.8	1.6
Short access day 10 total locomotion	1.9	2.0	3.2	1.5	1.4	-1.8	1.4	-0.8
Short access total locomotion	0.4	0.4	1.4	0.0	-0.4	-1.2	0.7	-0.4
Compulsive drug intake	0.4	0.4	1.6	0.0	0.5	-1.3	-0.2	-0.2
One hour access (0.3 mA shock)	2.9	3.4	5.2	2.0	1.3	-1.7	2.3	-1.8
One hour access (shock baseline)	1.2	1.4	4.2	1.2	0.3	-0.4	2.0	-1.0
Number of responses in last shaping day	2.1	2.2	3.9	-0.7	-0.1	2.0	-1.6	2.0
Context. condit. distance diff. score	1.0	1.2	3.3	-1.3	-1.8	0.9	-0.3	-0.3
Locomotion velocity, session 1	0.5	0.5	1.2	-0.7	-0.9	0.4	-1.1	-0.2
Locomotion distance, session 1	2.3	2.9	6.0	-2.0	-2.4	0.7	-1.9	0.6
Locomotion velocity, session 2	0.3	0.3	1.0	-0.3	0.3	0.0	-1.0	0.5
Locomotion distance, session 2	1.8	2.6	4.4	-1.8	-1.6	0.9	-2.1	1.4
Locomotion velocity, session 3	0.3	0.4	1.2	-0.2	-0.6	-0.6	-0.3	-1.1
Locomotion distance, session 3	0.7	0.8	1.7	-1.3	-1.0	0.5	-1.1	0.2
Stereotopy head waving bouts, day 3	0.9	1.0	3.3	1.0	-0.3	-0.4	0.8	-1.8
Stereotopy head waving duration, day 3	1.0	1.3	3.0	1.1	-0.2	-0.6	1.3	-1.7
Locomotion velocity, session 7	0.6	0.7	2.1	-1.0	-1.4	0.5	-0.1	0.2
Locomotion distance, session 7	0.7	0.9	1.9	-1.1	-0.4	0.4	-1.4	1.1
Stereotopy head waving bouts, day 7	0.6	0.7	1.8	0.1	-1.1	-0.3	0.5	-1.3
Stereotopy head waving duration, day 7	0.8	1.0	2.2	0.7	-0.3	-0.7	1.3	-1.5
Locomotion velocity, session 8	0.3	0.4	1.0	-0.5	-1.0	-0.1	0.4	-0.6
Locomotion distance, session 8	0.7	1.1	3.0	-1.2	-1.7	0.1	-0.9	-0.2
Degree of sensitization distance	0.3	0.3	0.8	0.5	0.9	-0.3	-0.3	0.5
Degree of sensitization stereotypy	0.2	0.2	0.5	0.1	-0.5	-0.1	0.3	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	0.4	-0.7	0.4	0.8	0.0
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.2	-0.0	-0.8	0.9	1.1	0.4
Condit. Reinf. active responses	0.4	0.4	1.3	-0.4	-1.2	0.5	-0.6	0.2
Condit. Reinf. inactive responses	0.6	0.8	2.3	-0.7	-1.0	-0.0	-1.5	-0.2
Incentive salience index mean	0.2	0.2	0.6	0.4	-0.7	-0.2	0.3	-0.4
Condit. Reinf. lever presses	0.6	0.7	2.3	-0.7	-1.5	-0.3	-0.9	-0.0
Time in familiar zone, hab. session 1	0.5	0.5	1.0	-0.7	-1.0	0.9	-0.1	-0.2
Time in novel zone, hab. session 1	0.5	0.5	0.9	0.8	1.0	-0.8	-0.1	-0.5
Total zone transitions, hab. session 1	0.3	0.4	1.0	-0.6	-0.9	0.1	-1.0	0.1
Total locomotion distance, hab. session 1	1.4	1.9	5.2	-1.3	-2.3	-0.3	-1.4	-0.9
Locomotion velocity, hab. session 1	1.1	1.6	4.1	-1.2	-2.0	-0.1	-1.4	-0.6
Time in familiar zone, hab. session 2	0.5	0.5	1.4	-1.2	-0.8	0.3	-0.2	0.6
Time in novel zone, hab. session 2	0.5	0.5	1.3	1.2	1.0	0.2	0.0	-0.4
Total zone transitions, hab. session 2	2.1	2.7	5.7	-1.9	-1.7	0.4	-2.4	0.9
Total locomotion distance, hab. session 2	2.0	2.7	5.2	-1.7	-2.3	-0.1	-2.2	-0.6
Locomotion velocity, hab. session 2	1.8	2.4	4.7	-1.6	-2.2	-0.3	-2.1	-0.7
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.1	-0.1	0.6	-0.3	0.2
Novelty place preference	0.1	0.1	0.2	0.2	0.4	0.5	-0.2	0.2
Time in novel zone, NPP test	0.2	0.2	0.5	0.2	0.3	0.7	-0.4	0.1
Total zone transitions, NPP test	0.8	1.2	2.8	-0.9	-1.4	0.1	-1.7	0.3
Total locomotion distance, NPP test	1.6	2.3	4.8	-1.6	-2.2	-0.1	-2.0	-0.0
Locomotion velocity, NPP test	1.5	2.2	4.7	-1.7	-2.2	-0.2	-1.9	0.1
Pavlov. Cond. lever latency	0.7	0.9	2.7	-0.3	-0.7	-0.9	1.7	-0.5
Pavlov. Cond. magazine entry latency	0.9	1.1	3.1	-0.3	0.1	1.1	-1.8	1.1
Pavlov. Cond. change in total contacts	1.1	1.1	2.6	-0.3	-0.3	1.4	-1.6	1.0
Pavlov. Cond. index score	1.0	1.3	3.8	-0.3	0.0	1.3	-1.9	1.0
Pavlov. Cond. latency score	1.0	1.3	4.0	-0.3	-0.1	1.2	-2.0	0.8
Pavlov. Cond. lever contacts	0.8	0.9	3.3	0.1	0.6	0.9	-1.8	0.6
Pavlov. Cond. magazine entry number	1.1	1.4	3.4	0.6	-0.0	-1.2	1.9	-1.3
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.9	1.7	1.4	-0.5	1.1	-1.4
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	4.0	-0.3	0.0	1.5	-2.0	1.0
Pavlov. Cond. response bias	0.6	0.8	2.6	-0.2	0.2	0.8	-1.6	0.8
Bone: apparent density	1.9	3.1	6.6	-1.7	-1.3	2.6	-0.7	1.9
Bone surface	1.5	2.7	4.9	-1.6	-1.6	2.2	-1.4	1.3
Bone volume	1.3	2.2	4.3	-1.5	-1.8	2.1	-0.3	1.1
Bone: connectivity density	1.8	2.9	6.8	-1.4	-1.1	2.6	-0.9	1.9
Bone: cortical apparent density	0.1	0.1	0.2	0.2	-0.0	-0.4	-0.0	-0.4
Bone: cortical area	1.2	1.8	3.5	-1.1	-1.9	1.5	-1.1	1.0
Bone: cortical porosity	0.3	0.3	0.9	-0.5	-0.3	0.2	-0.6	1.0
Bone: cortical porosity	0.2	0.2	0.7	-0.1	0.2	0.4	-0.4	0.9
Bone: cortical thickness	0.4	0.6	1.0	-0.4	-0.8	1.0	-1.0	0.6
Bone: cortical thickness	1.2	1.4	3.5	-0.1	0.2	1.9	-1.5	1.0
Bone: cortical tissue density	0.1	0.2	0.3	0.4	0.2	-0.5	0.1	-0.5
Bone: elastic displacement	0.5	0.5	1.0	-0.7	-0.6	0.2	-1.0	0.8
Bone: elastic work	0.4	0.6	0.7	-0.4	-0.8	0.8	-0.9	0.8
Bone: endosteal estimation	0.3	0.7	1.3	-1.1	-1.1	0.6	-0.0	0.7
Bone: endosteal perimeter	1.0	2.0	4.9	-1.8	-2.2	0.9	-0.4	1.0
Bone: final force	1.6	2.7	4.5	-1.5	-1.3	2.1	-1.4	1.7
Bone: final moment	2.1	3.5	5.7	-1.8	-1.3	2.4	-1.7	2.0
Bone: marrow area	0.3	0.6	1.2	-1.1	-1.1	0.5	-0.1	0.7
Bone: maximum diameter	0.2	0.4	1.7	-0.4	-1.3	0.0	0.4	-0.1
Bone: maximum force	2.0	3.4	6.0	-1.8	-2.0	2.4	-1.2	1.6
Bone: maximum moment	2.5	4.3	7.3	-2.1	-2.0	2.7	-1.5	1.9
Bone: minimum diameter	0.5	1.0	2.5	-1.0	-1.6	0.7	-0.7	0.6
Bone: periosteal estimation	0.6	1.2	3.1	-1.2	-1.8	0.9	-0.4	0.7
Bone: periosteal perimeter	1.1	1.9	4.9	-1.5	-2.2	1.0	-0.6	1.0
Bone: post-yield work	1.3	1.8	3.3	-1.3	-1.8	1.8	-0.5	0.6
Bone: stiffness	0.3	0.5	1.5	-0.5	-0.8	1.2	0.1	0.4
Bone: tissue strength	0.3	0.3	0.9	-0.4	-0.9	0.4	0.1	-0.2
Bone: trabecular number	2.6	4.0	7.5	-2.1	-2.1	2.7	-0.6	1.8
Bone: trabecular spacing	1.7	2.2	3.4	1.6	1.2	-1.8	1.4	-1.3
Bone: trabecular thickness	0.2	0.2	0.7	-0.5	-0.9	0.4	0.2	0.3
Bone: trabecular tissue density	2.1	2.9	5.7	1.6	0.6	-2.0	1.4	-2.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.1	0.3	-0.2	0.3	-0.2
Distance traveled before self-admin	0.8	0.9	3.1	-0.2	0.0	1.8	-0.8	0.8
Distance traveled after self-admin	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.5	-0.3
Delta time in closed arm before/after self-admin	1.6	1.5	2.6	-1.1	-0.9	1.2	-1.6	1.2
Delta time in open arm before/after self-admin	5.1	4.9	8.7	2.6	2.9	-1.3	2.5	-1.0
Diff in mean of infusions in LGA sessions	0.8	0.9	1.9	0.8	0.7	-1.4	0.8	-0.9
Extinction: sum of active levers before priming	1.3	1.3	3.5	0.1	-0.5	-1.2	1.9	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.8	-0.4	-0.2	-0.3	0.9	0.6
Delta distance traveled before/after self-admin	0.5	0.6	1.3	-0.1	-0.7	-1.0	0.5	-1.1
Delta ambulatory time before/after self-admin	1.4	1.5	4.1	0.8	-0.3	-1.4	0.9	-2.0
Time in closed arm before self-admin	0.6	0.6	1.1	-1.1	-0.8	0.5	-0.8	0.8
Time in closed arm after self-admin	3.1	3.3	4.3	-2.1	-1.6	1.4	-1.9	1.9
Time in open arm before self-admin	0.7	0.8	2.4	-1.1	-1.6	-0.2	-0.3	-0.3
Time in open arm after self-admin	0.6	0.7	1.3	0.7	0.8	-0.8	1.1	-0.4
Sum of active levers in priming session hrs 5-6	2.0	1.9	5.4	1.2	0.8	-0.6	2.3	-1.3
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.9	1.4	1.3	0.7	0.0	0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.3	0.2	-0.6	0.7	0.3
Time to tail flick, test, before self-admin	1.1	1.1	3.7	0.7	0.7	1.9	0.4	0.8
Time to tail flick, test, after self-admin	0.5	0.5	1.1	0.8	0.7	1.1	0.3	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	-0.5	-0.6	-1.0	0.6	-0.3
Delta time to tail flick, test, before/after SA	0.4	0.3	0.8	0.1	-0.1	-0.9	0.0	-0.9
Ambulatory time before self-admin	1.3	1.4	3.8	-0.6	-0.2	1.9	-1.2	1.2
Ambulatory time after self-admin	0.8	0.8	1.8	-0.4	-0.7	1.3	-1.3	-0.3
Total heroin consumption	0.2	0.3	0.5	0.5	0.4	0.3	0.6	-0.7
Area under the delay curve	0.9	0.9	2.3	-1.0	-0.6	0.2	-1.5	1.0
Delay disc. indifference point, 0s delay	1.8	1.9	6.0	-0.9	-0.7	1.2	-2.5	0.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	0.6	0.2	-0.7	0.3	-0.2
Delay disc. indifference point, 2s delay	1.2	1.4	2.3	-1.3	-0.8	0.9	-1.5	1.2
Delay disc. indifference point, 24s delay	1.6	1.5	4.1	0.9	0.7	-2.0	1.1	-1.1
Delay disc. indifference point, 4s delay	4.2	4.4	8.5	-2.0	-1.6	1.9	-2.9	1.8
Delay disc. indifference point, 8s delay	0.6	0.6	1.4	-1.0	-0.3	0.2	-0.9	1.2
Delay discount exponential model param	0.8	0.9	2.0	1.0	0.7	0.0	1.4	-0.9
Delay discount hyperbolic model param	1.5	1.6	3.3	1.4	0.9	-0.5	1.8	-1.3
Fecal boli incidents, locomotor time 1	0.7	0.8	1.8	-0.5	0.0	1.3	-0.5	1.3
Change in fecal boli incidents, locomotor task	0.9	0.8	2.7	-0.6	-0.6	-0.5	-1.7	-0.6
Time >=10cm from walls, locomotor time 1	1.0	1.1	2.8	-1.5	-1.7	-0.1	0.1	0.5
Bouts of movement, locomotor time 1	1.0	1.1	3.0	0.9	1.7	-1.2	0.5	0.1
Total resting periods, locomotor time 1	1.1	1.3	2.5	1.0	1.6	-1.6	0.5	-0.2
Rest time, locomotor task time 1	0.1	0.1	0.3	0.1	0.4	-0.6	-0.1	0.0
Distance moved, locomotor task time 1	1.1	1.2	3.5	-0.8	-0.6	1.9	-0.9	0.7
Vertical activity count, locomotor time 1	1.3	1.3	5.2	-0.2	-0.6	2.3	-1.0	0.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.2	0.7	0.2	0.0	-0.3	-1.1
Bouts of movement, locomotor time 2	0.5	0.5	0.9	0.9	0.8	-0.4	0.5	-0.8
Total resting periods, locomotor time 2	0.7	0.8	1.3	1.1	1.0	-0.7	0.5	-0.9
Rest time, locomotor task time 2	0.3	0.3	0.5	-0.4	-0.5	-0.7	0.7	-0.4
Distance moved, locomotor task time 2	0.2	0.3	0.9	0.3	1.0	0.5	0.0	0.3
Vertical activity count, locomotor time 2	0.7	0.7	2.5	-0.3	-0.1	1.6	-0.8	0.7
Weight adjusted by age	1.5	1.7	4.8	-1.8	-2.2	-0.4	-0.4	-0.2
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	4.2	-2.1	-1.6	1.1	-1.3	1.4
Locomotion in novel chamber	2.6	3.2	4.6	-1.9	-1.7	1.7	-1.5	2.1
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	0.4	0.9	0.5	-1.0	0.6
Progressive ratio	1.4	1.7	5.2	0.6	0.1	-1.5	2.3	-0.8
Food seeking constrained by brief footshock	0.8	1.0	2.3	-1.3	-1.5	0.3	0.6	0.7
Seeking ratio, punishment vs. effort	2.1	2.5	3.4	-1.8	-1.6	1.6	-1.5	1.3
Run reversals in cocaine runway, females	0.4	0.4	0.8	-0.5	-0.1	0.9	-0.7	0.7
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.2	-0.3	0.8	-0.3	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.7	0.5	0.4	0.3	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.4	0.2	0.1	0.5	0.2
Latency to leave start box in cocaine runway, M	0.4	0.3	1.0	0.4	0.4	1.0	-0.6	0.2
Cd content in liver	0.5	0.5	1.8	0.6	-0.1	-0.7	-0.2	-1.3
Co content in liver	0.9	1.0	1.6	0.3	1.0	1.1	-1.1	1.3
Cu content in liver	2.5	3.1	4.4	-1.7	-1.1	1.7	-1.9	2.1
Fe content in liver	0.7	0.9	1.3	-0.5	-1.2	1.1	-1.0	0.8
K content in liver	4.0	4.0	7.1	1.3	1.4	-2.1	2.7	-2.2
Mg content in liver	1.3	1.3	3.0	0.6	0.8	-0.9	1.7	-1.3
Mn content in liver	1.1	1.3	3.6	0.6	0.7	-1.3	1.9	-0.4
Na content in liver	1.1	1.2	2.1	-1.2	-0.5	1.5	-1.3	0.5
Rb content in liver	0.8	1.0	3.5	0.8	1.9	0.3	-0.2	0.9
Se content in liver	0.3	0.4	1.4	-0.2	-0.2	1.2	0.6	-0.0
Sr content in liver	2.1	1.9	3.3	-1.5	-0.8	1.6	-0.8	1.8
Zn content in liver	0.6	0.6	0.9	-0.8	-0.8	0.6	-0.7	0.9