Hub : Genes

Ecrg4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000023576	0.45	0.18	0.0e+00	0.23	0.23	0.23	0.24	3.8e-25	5.3e-25	9.4e-26	7.6e-27
2	Liver	gene expression	ENSRNOG00000023576	0.1	0.07	2.1e-12	0.07	0.07	0.06	0.06	3.4e-08	4.7e-08	2.2e-07	1.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.7	8.7	9.8	-2.8	3.1
BMI without tail	0.1	0.1	0.1	0.4	-0.3
Body weight	0.1	0.5	0.5	-0.7	0.7
Epididymis fat weight	0.0	0.0	0.1	0.2	0.0
Glucose	0.0	0.0	0.0	0.1	-0.1
Heart weight	0.4	0.6	0.8	-0.7	0.9
Left kidney weight	0.0	0.1	0.2	0.4	-0.2
Right kidney weight	0.0	0.1	0.2	0.4	-0.2
Tail length	1.2	3.7	4.6	1.6	-2.2
Length with tail	0.3	1.2	1.5	0.9	-1.2
Length without tail	1.3	2.9	3.2	-1.6	1.8
Liver weight, left	0.4	0.6	1.0	1.0	-0.5
Liver weight, right	0.2	0.4	0.4	0.7	-0.6
Parametrial fat weight	0.1	0.2	0.2	-0.4	0.4
Retroperitoneal fat weight	0.2	0.8	0.9	-0.9	0.9
Intraocular pressure	2.6	3.6	3.9	-2.0	1.8
Extensor digitorum longus weight	6.4	25.7	27.3	-4.9	5.2
Soleus weight	0.7	2.0	2.6	-1.2	1.6
Tibialis anterior weight	1.9	6.5	7.1	-2.4	2.7
Tibia length	0.1	0.3	0.3	0.5	-0.5
Number of licking bursts	0.3	0.4	0.4	0.6	-0.6
Food consumed during 24 hour testing period	0.9	1.0	1.1	-1.0	1.0
Times rat made contact with spout	0.4	0.5	0.6	0.6	-0.8
Mean time between licks in bursts	0.8	1.1	1.6	-0.8	1.3
Mean num. licks in bursts	0.3	0.4	0.4	-0.6	0.6
Std. dev. time between licks in bursts	0.5	0.6	0.9	-0.6	0.9
Water consumed over 24 hours	0.4	0.5	0.6	-0.8	0.6
Indifference point 0 sec	0.1	0.1	0.2	0.2	0.5
Indifference point AUC	1.1	1.3	1.4	-1.1	1.2
Indifference point function ln k	0.1	0.2	0.2	-0.4	0.4
Indifference point function log k	0.1	0.2	0.2	-0.4	0.4
Delay discounting total patch changes 0 sec	0.2	0.3	0.6	-0.1	0.8
Delay discounting total patch changes 12 sec	0.0	0.1	0.1	0.3	0.2
Delay discounting total patch changes 18 sec	1.2	1.6	2.3	-1.0	1.5
Delay discounting total patch changes 24 sec	0.2	0.3	0.5	-0.1	0.7
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	0.4	0.1
Delay discounting time to switch 0 sec	0.8	1.2	1.3	1.1	-1.0
Delay discounting water rate 0 sec	0.8	1.3	1.4	-1.1	1.2
Delay discounting water rate 12 sec	0.0	0.0	0.0	0.1	0.2
Delay discounting water rate 18 sec	0.6	0.8	0.8	0.9	-0.9
Delay discounting water rate 24 sec	0.0	0.0	0.0	-0.1	-0.0
Delay discounting water rate 6 sec	0.0	0.0	0.0	0.2	-0.0
Locomotor activity	0.3	0.4	0.5	0.6	-0.7
Locomotor testing distance	1.7	2.9	3.0	1.7	-1.7
Locomotor testing rearing	2.2	3.4	4.0	1.7	-2.0
Light reinforcement 1	3.7	6.7	7.6	-2.4	2.8
Light reinforcement 2	1.1	1.5	2.0	-1.0	1.4
Reaction time number correct	1.1	1.6	1.6	-1.2	1.3
Reaction time mean minus median	1.9	2.4	2.6	1.5	-1.6
Reaction time mean minus median AUC	1.6	2.1	2.4	1.3	-1.5
Reaction time num false alarms	1.8	2.5	2.8	-1.7	1.5
Reaction time num false alarms AUC	2.5	3.5	3.6	-1.9	1.9
Reaction time trials correct on left	1.1	1.6	1.6	-1.2	1.3
Reaction time trials on left	1.0	1.5	1.5	-1.2	1.2
Reaction time mean	2.2	3.0	3.2	1.7	-1.8
Reaction time mean AUC	1.5	1.9	2.2	1.3	-1.5
Median of all reaction times	1.4	1.9	2.1	1.3	-1.4
Reaction time omissions	1.0	1.3	1.4	1.2	-1.1
Reaction time false alarm rate	0.6	0.9	0.9	-0.9	0.9
Reaction time premature initiation rate	0.0	0.1	0.1	0.2	-0.3
Reaction time premature initiations	0.1	0.2	0.2	-0.4	0.4
Std. dev. reaction times	3.1	4.3	4.3	2.1	-2.1
Reaction time trials completed	1.0	1.5	1.5	-1.2	1.2
Reaction time trials AUC	1.0	1.5	1.5	-1.2	1.2
Social response proportion	0.1	0.1	0.1	-0.2	0.3
Social responses	0.3	0.4	0.5	0.5	-0.7
Social time	3.7	4.9	4.9	2.2	-2.2
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1
Cocaine response after cond. corrected	1.0	1.1	1.3	-1.1	1.0
Cocaine response after cond. not corrected	0.9	1.0	1.2	-1.1	0.9
Cocaine response before conditioning	0.0	0.0	0.0	0.2	-0.1
Saline control response	0.2	0.3	0.3	-0.6	0.4
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.4	-0.9
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.7	0.9	-1.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.1
Condit. Reinf. inactive responses	0.8	0.9	1.1	-0.9	1.0
Condit. Reinf. lever presses	0.4	0.5	0.6	0.6	-0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	-0.6	0.3
Pavlov. Cond. lever latency	0.6	0.8	0.9	-0.9	0.9
Pavlov. Cond. magazine entry latency	0.7	0.8	0.8	0.8	-0.9
Pavlov. Cond. change in total contacts	0.6	0.9	1.0	1.0	-0.9
Pavlov. Cond. index score	0.5	0.7	0.7	0.8	-0.8
Pavlov. Cond. latency score	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. lever contacts	1.8	2.5	2.5	1.6	-1.5
Pavlov. Cond. magazine entry number	1.3	1.7	1.7	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	4.2	5.4	5.5	-2.3	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. response bias	2.4	3.4	3.5	1.9	-1.8
Conditioned reinforcement - actives	0.1	0.1	0.1	0.2	-0.3
Conditioned reinforcement - inactives	0.1	0.2	0.2	0.3	-0.5
Conditioned locomotion	1.1	1.3	1.5	-1.0	1.2
Intermittent access intake day 1-15 change	0.3	0.3	0.4	0.5	-0.6
Intermittent access intake escalation	0.9	0.8	1.1	0.7	-1.1
Intermittent access intake escalation 2	1.3	1.3	1.8	0.9	-1.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.5	0.7	-0.5
Intermitt. access escalation Index	0.2	0.1	0.3	-0.5	0.1
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 15 total infusions	0.4	0.5	0.7	0.6	-0.8
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	0.1	-0.3
Intermittent access total infusions	0.1	0.1	0.1	0.3	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.2	0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	0.2
Intermittent access total locomotion	0.1	0.1	0.1	-0.2	0.3
Intermittent access standard deviation	0.6	0.6	0.7	0.8	-0.8
Cocaine induced anxiety	1.4	1.6	1.8	-1.2	1.3
Post-drug Anxiety	3.1	3.4	3.6	-1.9	1.8
Baseline Anxiety	0.1	0.1	0.1	-0.3	0.1
Lifetime Intake	0.0	0.0	0.0	0.0	0.0
Incentive Sensitization - Responses	1.0	1.0	1.2	0.9	-1.1
Incentive Sensitization - Breakpoint	0.7	0.7	0.9	0.8	-0.9
Progressive ratio test 1 active lever presses	0.8	0.8	0.8	-0.9	0.9
Progressive ratio test 1 breakpoint	0.8	0.8	0.8	-0.9	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.3	-0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.2	0.3	-0.5
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.7	0.8	-0.8
Total sessions with >9 infusions	2.2	2.4	2.6	-1.5	1.6
Short access day 1 total inactive lever presses	0.4	0.4	0.6	0.8	-0.4
Short access day 10 total inactive lever presses	0.4	0.4	0.5	0.6	-0.7
Short access day 1 total infusions	0.1	0.1	0.1	-0.0	0.3
Short access day 10 total infusions	0.2	0.2	0.2	-0.4	0.4
Short access total infusions	0.6	0.7	0.8	-0.7	0.9
Short access day 1 locomotion	0.4	0.4	0.5	-0.5	0.7
Short access day 10 total locomotion	0.2	0.3	0.3	0.6	-0.4
Short access total locomotion	0.6	0.6	0.7	-0.7	0.8
Compulsive drug intake	1.8	1.8	1.9	1.3	-1.4
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.3	-0.6
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	-0.1
Number of responses in last shaping day	0.1	0.1	0.1	0.4	-0.4
Context. condit. distance diff. score	0.9	1.0	1.3	0.9	-1.1
Locomotion velocity, session 1	0.1	0.1	0.3	-0.5	0.2
Locomotion distance, session 1	1.2	1.5	1.9	-1.4	1.1
Locomotion velocity, session 2	3.5	4.2	4.5	-1.9	2.1
Locomotion distance, session 2	3.5	5.0	5.2	-2.2	2.3
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	-0.4
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.2
Stereotopy head waving bouts, day 3	0.4	0.5	0.5	0.7	-0.7
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.4	-0.6
Locomotion velocity, session 7	0.2	0.2	0.3	-0.3	0.6
Locomotion distance, session 7	0.6	0.8	0.9	-0.9	0.9
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.2	-0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.3	0.3	-0.5
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	0.0
Locomotion distance, session 8	0.6	0.9	0.9	-0.9	1.0
Degree of sensitization distance	1.3	1.4	1.4	-1.2	1.2
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	-0.2
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	-1.1	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.9	-0.9	0.2
Condit. Reinf. active responses	0.3	0.4	0.7	-0.8	0.4
Condit. Reinf. inactive responses	0.5	0.6	0.6	-0.8	0.8
Incentive salience index mean	0.1	0.1	0.2	-0.5	0.0
Condit. Reinf. lever presses	0.3	0.4	0.5	0.4	-0.7
Time in familiar zone, hab. session 1	0.1	0.0	0.1	-0.3	0.0
Time in novel zone, hab. session 1	1.1	1.1	1.2	1.1	-1.0
Total zone transitions, hab. session 1	0.2	0.3	0.3	0.6	-0.4
Total locomotion distance, hab. session 1	0.6	0.9	1.0	-0.9	1.0
Locomotion velocity, hab. session 1	0.5	0.7	0.9	-0.7	0.9
Time in familiar zone, hab. session 2	0.6	0.6	0.7	0.8	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	0.3
Total zone transitions, hab. session 2	0.4	0.5	0.6	-0.7	0.7
Total locomotion distance, hab. session 2	1.6	2.2	2.4	-1.6	1.4
Locomotion velocity, hab. session 2	1.3	1.8	2.0	-1.4	1.3
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.4	0.3
Novelty place preference	0.1	0.1	0.1	-0.3	0.2
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	0.0
Total zone transitions, NPP test	0.5	0.7	0.9	-0.9	0.6
Total locomotion distance, NPP test	0.7	1.0	1.0	-1.0	1.0
Locomotion velocity, NPP test	1.0	1.4	1.4	-1.2	1.2
Pavlov. Cond. lever latency	0.3	0.4	0.5	-0.5	0.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.2	-0.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.7	0.5
Pavlov. Cond. index score	0.2	0.2	0.3	0.4	-0.5
Pavlov. Cond. latency score	0.3	0.3	0.4	0.5	-0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.2	0.3	-0.4
Pavlov. Cond. magazine entry number	0.6	0.8	0.9	-0.8	1.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.3
Bone: apparent density	5.2	8.6	9.0	3.0	-2.9
Bone surface	0.4	0.8	1.1	1.0	-0.7
Bone volume	2.3	3.8	4.3	2.1	-1.8
Bone: connectivity density	1.2	1.8	2.2	1.5	-1.2
Bone: cortical apparent density	2.2	2.9	3.2	-1.6	1.8
Bone: cortical area	0.2	0.2	0.3	-0.4	0.6
Bone: cortical porosity	1.5	1.6	1.6	1.3	-1.2
Bone: cortical porosity	1.8	2.0	2.0	1.4	-1.4
Bone: cortical thickness	0.3	0.5	0.5	-0.6	0.7
Bone: cortical thickness	0.1	0.1	0.1	-0.3	0.3
Bone: cortical tissue density	2.1	2.7	3.0	-1.5	1.7
Bone: elastic displacement	0.8	0.9	1.1	1.1	-0.8
Bone: elastic work	0.5	0.6	0.6	0.8	-0.8
Bone: endosteal estimation	0.0	0.0	0.0	0.2	-0.1
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.1
Bone: final force	0.2	0.4	0.4	-0.6	0.6
Bone: final moment	0.2	0.4	0.4	-0.6	0.7
Bone: marrow area	0.0	0.0	0.0	0.1	-0.0
Bone: maximum diameter	0.1	0.1	0.2	0.4	-0.2
Bone: maximum force	0.2	0.4	0.4	-0.6	0.7
Bone: maximum moment	0.2	0.4	0.5	-0.6	0.7
Bone: minimum diameter	0.4	0.7	1.0	-0.7	1.0
Bone: periosteal estimation	0.0	0.0	0.0	0.1	0.0
Bone: periosteal perimeter	0.0	0.0	0.0	-0.1	0.1
Bone: post-yield work	0.1	0.2	0.2	0.4	-0.4
Bone: stiffness	0.3	0.5	0.5	-0.7	0.7
Bone: tissue strength	0.4	0.4	0.5	-0.7	0.6
Bone: trabecular number	4.2	6.5	6.7	2.6	-2.5
Bone: trabecular spacing	3.4	4.3	4.4	-2.1	2.1
Bone: trabecular thickness	5.7	6.9	7.2	2.6	-2.7
Bone: trabecular tissue density	0.1	0.2	0.2	0.4	-0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.2	0.4	-0.5
Distance traveled before self-admin	0.3	0.3	0.4	0.6	-0.4
Distance traveled after self-admin	3.9	4.3	4.7	2.2	-2.0
Delta time in closed arm before/after self-admin	1.0	0.9	1.3	1.2	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	-0.4
Diff in mean of infusions in LGA sessions	0.8	0.9	1.0	0.9	-1.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	-0.1
Active lever presses in extinction session 6	1.7	1.6	2.1	-1.5	1.1
Delta distance traveled before/after self-admin	0.7	0.8	0.8	0.9	-0.9
Delta ambulatory time before/after self-admin	0.6	0.6	0.7	0.8	-0.7
Time in closed arm before self-admin	0.1	0.1	0.2	-0.5	0.3
Time in closed arm after self-admin	0.7	0.7	0.9	0.9	-0.7
Time in open arm before self-admin	0.3	0.4	0.5	-0.5	0.7
Time in open arm after self-admin	0.4	0.4	0.5	0.6	-0.7
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.4	0.6	-0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	-0.0
Time to tail flick, test, before self-admin	0.6	0.6	0.7	-0.8	0.8
Time to tail flick, test, after self-admin	2.7	2.8	3.3	-1.8	1.5
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.2	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	-0.4	0.3
Ambulatory time before self-admin	0.0	0.1	0.1	0.3	-0.2
Ambulatory time after self-admin	0.8	0.9	1.2	1.1	-0.8
Total heroin consumption	0.1	0.2	0.2	-0.5	0.3
Area under the delay curve	0.3	0.4	0.6	-0.8	0.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.2	-0.4	0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.1	-0.4
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	-0.6	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.1	-0.4
Delay disc. indifference point, 4s delay	0.8	0.9	1.1	-1.1	0.8
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	0.1
Delay discount exponential model param	0.3	0.3	0.5	0.7	-0.3
Delay discount hyperbolic model param	0.6	0.6	0.9	1.0	-0.6
Fecal boli incidents, locomotor time 1	2.8	3.1	3.1	-1.7	1.8
Change in fecal boli incidents, locomotor task	0.2	0.1	0.2	0.4	-0.3
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.0	-1.3	1.4
Bouts of movement, locomotor time 1	10.2	11.3	12.1	-3.5	3.2
Total resting periods, locomotor time 1	10.3	11.5	12.2	-3.5	3.3
Rest time, locomotor task time 1	1.1	1.2	1.4	-1.2	1.0
Distance moved, locomotor task time 1	0.3	0.3	0.4	0.7	-0.4
Vertical activity count, locomotor time 1	1.6	1.7	2.0	1.4	-1.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	0.0
Bouts of movement, locomotor time 2	3.2	3.4	3.6	-1.8	1.9
Total resting periods, locomotor time 2	2.8	3.0	3.2	-1.6	1.8
Rest time, locomotor task time 2	0.0	0.1	0.1	0.2	-0.2
Distance moved, locomotor task time 2	0.3	0.3	0.4	-0.5	0.6
Vertical activity count, locomotor time 2	0.4	0.4	0.5	-0.7	0.6
Weight adjusted by age	0.0	0.1	0.1	-0.2	0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	0.4	-0.5
Locomotion in novel chamber	7.7	9.6	9.6	-3.1	3.1
Locomotion in novel chamber post-restriction	3.8	4.5	4.7	-2.2	2.1
Progressive ratio	3.2	3.7	4.6	-2.1	1.7
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.1	-0.0
Seeking ratio, punishment vs. effort	1.7	2.1	2.6	1.6	-1.2
Run reversals in cocaine runway, females	0.6	0.6	0.7	-0.8	0.7
Run reversals in cocaine runway, males	0.4	0.4	0.4	-0.6	0.6
Latency to leave start box in cocaine runway	2.6	2.8	3.1	-1.6	1.8
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.0	0.3
Latency to leave start box in cocaine runway, M	6.4	6.1	6.3	-2.4	2.5
Cd content in liver	0.1	0.1	0.1	0.3	-0.3
Co content in liver	0.2	0.2	0.4	0.2	-0.7
Cu content in liver	0.3	0.3	0.6	0.3	-0.8
Fe content in liver	2.9	3.5	3.6	1.8	-1.9
K content in liver	0.8	0.8	1.1	-0.7	1.1
Mg content in liver	0.1	0.1	0.1	-0.1	0.4
Mn content in liver	0.2	0.2	0.2	-0.4	0.5
Na content in liver	1.5	1.6	2.2	1.5	-1.0
Rb content in liver	3.7	4.7	5.1	-2.3	2.0
Se content in liver	0.3	0.4	0.4	-0.5	0.6
Sr content in liver	0.0	0.0	0.0	-0.1	0.1
Zn content in liver	0.0	0.0	0.0	-0.0	-0.1