Hub : Genes

Skint10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000022988	0.21	0.1	3.1e-12	0.18	0.2	0.16	0.17	6.1e-10	9.8e-11	3.5e-09	1.6e-09
2	Brain	gene expression	ENSRNOG00000022988	0.08	0.05	2.9e-08	0.11	0.1	0.09	0.09	4.8e-10	3.7e-09	5.0e-09	8.3e-09
3	IL	gene expression	ENSRNOG00000022988	0.17	0.1	4.8e-03	0.07	0.01	0.01	0	7.6e-03	1.6e-01	1.7e-01	2.9e-01
4	OFC	gene expression	ENSRNOG00000022988	0.27	0.13	2.1e-05	0.06	0.16	0.14	0.15	1.8e-02	1.3e-04	3.2e-04	2.0e-04
5	PL	alternative polyA	ENSRNOT00000106746	0.06	0.04	2.4e-04	0.07	0.05	0.05	0.07	7.2e-06	9.8e-05	8.3e-05	8.4e-06
6	PL	gene expression	ENSRNOG00000022988	0.23	0.11	0.0e+00	0.21	0.22	0.23	0.22	1.1e-15	6.1e-17	2.8e-17	2.7e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	1.1	3.7	6.5	1.9	1.9	1.9	1.5	-2.5	1.6
BMI without tail	0.0	0.1	0.4	-0.3	-0.1	-0.1	-0.6	0.1	-0.3
Body weight	0.2	0.8	2.8	0.7	1.0	0.9	-0.1	-1.7	0.3
Epididymis fat weight	0.0	0.1	0.3	-0.2	0.0	-0.0	-0.6	-0.2	-0.2
Glucose	0.1	0.1	0.5	0.1	-0.0	-0.1	0.7	-0.3	0.3
Heart weight	0.9	1.3	3.1	0.9	1.4	1.3	-0.1	-1.8	0.6
Left kidney weight	5.7	16.2	26.4	4.0	4.4	4.4	2.5	-5.1	3.3
Right kidney weight	3.1	8.8	16.1	3.0	3.1	3.1	1.7	-4.0	2.3
Tail length	1.8	5.4	8.3	-2.4	-2.0	-2.1	-2.9	2.1	-2.4
Length with tail	0.6	2.3	5.1	-1.5	-1.1	-1.2	-2.3	0.8	-1.8
Length without tail	0.1	0.1	0.7	0.2	0.3	0.2	-0.1	-0.8	-0.1
Liver weight, left	0.3	0.6	1.0	0.7	0.8	0.8	0.4	-1.0	0.6
Liver weight, right	0.2	0.3	0.7	-0.4	-0.2	-0.2	-0.8	-0.4	-0.8
Parametrial fat weight	2.5	4.9	6.7	-2.3	-2.2	-2.2	-2.4	1.2	-2.6
Retroperitoneal fat weight	0.4	1.3	1.7	-1.3	-1.2	-1.3	-1.1	0.8	-1.2
Intraocular pressure	0.0	0.0	0.1	-0.0	-0.2	-0.2	-0.0	-0.4	-0.2
Extensor digitorum longus weight	1.1	4.5	9.2	2.1	2.0	2.0	1.6	-3.0	1.7
Soleus weight	2.3	6.8	8.7	2.6	2.5	2.5	2.6	-3.0	2.5
Tibialis anterior weight	2.4	8.1	16.2	2.8	2.6	2.6	2.4	-4.0	2.3
Tibia length	0.4	1.2	4.3	-1.0	-0.3	-0.3	-2.1	0.8	-1.1
Number of licking bursts	0.1	0.2	0.4	0.3	-0.1	-0.1	0.6	-0.6	0.2
Food consumed during 24 hour testing period	0.3	0.4	0.9	-0.6	-0.3	-0.3	-0.9	1.0	-0.4
Times rat made contact with spout	0.1	0.1	0.2	-0.2	0.1	0.1	-0.5	0.3	-0.1
Mean time between licks in bursts	0.1	0.1	0.5	-0.1	-0.1	-0.1	-0.1	0.7	-0.1
Mean num. licks in bursts	0.1	0.1	0.4	-0.1	0.3	0.3	-0.6	0.4	-0.0
Std. dev. time between licks in bursts	1.6	1.9	2.7	-1.4	-1.4	-1.4	-1.1	1.6	-1.3
Water consumed over 24 hours	0.2	0.3	0.7	-0.4	-0.1	-0.1	-0.8	0.8	-0.2
Indifference point 0 sec	0.8	1.3	2.1	-1.2	-1.2	-1.2	-0.9	1.4	-0.9
Indifference point AUC	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.1	-0.4
Indifference point function ln k	0.0	0.0	0.1	0.1	0.0	0.0	0.3	0.2	0.2
Indifference point function log k	0.0	0.0	0.1	0.1	0.0	0.0	0.3	0.2	0.2
Delay discounting total patch changes 0 sec	1.1	1.8	2.6	-1.4	-1.4	-1.4	-1.2	1.6	-1.1
Delay discounting total patch changes 12 sec	1.5	1.9	2.7	-1.4	-1.3	-1.3	-1.4	1.6	-1.2
Delay discounting total patch changes 18 sec	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.4	0.1	-0.2
Delay discounting total patch changes 24 sec	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2	-0.1	-0.1
Delay discounting total patch changes 6 sec	0.6	0.9	1.1	-1.0	-0.8	-0.8	-1.0	1.0	-0.8
Delay discounting time to switch 0 sec	0.1	0.2	0.3	-0.4	-0.5	-0.5	-0.3	0.6	-0.4
Delay discounting water rate 0 sec	0.2	0.3	0.4	0.5	0.5	0.5	0.5	-0.7	0.4
Delay discounting water rate 12 sec	0.8	1.1	1.9	1.0	1.2	1.2	0.6	-1.4	0.8
Delay discounting water rate 18 sec	0.5	0.6	0.9	-0.8	-1.0	-1.0	-0.3	0.7	-0.8
Delay discounting water rate 24 sec	0.4	0.5	0.6	-0.8	-0.7	-0.7	-0.7	0.7	-0.7
Delay discounting water rate 6 sec	0.1	0.2	0.4	0.3	0.6	0.6	0.1	-0.6	0.2
Locomotor activity	0.2	0.3	0.8	-0.5	-0.1	-0.1	-0.9	0.9	-0.3
Locomotor testing distance	0.2	0.3	0.8	-0.3	0.3	0.3	-0.9	0.8	-0.0
Locomotor testing rearing	0.1	0.1	0.4	-0.1	0.3	0.3	-0.6	0.5	0.1
Light reinforcement 1	0.5	1.0	1.2	-1.0	-1.1	-1.1	-0.6	1.0	-1.0
Light reinforcement 2	0.8	1.1	3.2	1.0	0.6	0.6	1.8	-0.7	1.1
Reaction time number correct	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.0	-0.5
Reaction time mean minus median	0.3	0.4	0.7	0.5	0.8	0.8	0.3	-0.2	0.7
Reaction time mean minus median AUC	0.4	0.6	1.0	0.6	1.0	1.0	0.1	-0.6	0.8
Reaction time num false alarms	1.2	1.6	2.5	1.2	1.6	1.6	0.8	-1.0	1.3
Reaction time num false alarms AUC	0.9	1.3	2.0	1.1	1.4	1.4	0.6	-0.7	1.2
Reaction time trials correct on left	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.0	-0.5
Reaction time trials on left	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.2	0.0	-0.4
Reaction time mean	0.0	0.0	0.1	0.0	0.2	0.2	-0.1	0.3	0.2
Reaction time mean AUC	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3	0.3	-0.0
Median of all reaction times	0.1	0.1	0.3	-0.4	-0.2	-0.2	-0.4	0.5	-0.3
Reaction time omissions	0.7	1.0	1.5	0.9	1.2	1.2	0.7	-0.5	1.2
Reaction time false alarm rate	1.4	2.0	3.2	1.4	1.8	1.8	0.8	-1.0	1.5
Reaction time premature initiation rate	1.4	1.9	2.7	-1.4	-1.3	-1.3	-1.3	1.6	-1.3
Reaction time premature initiations	1.4	2.1	2.4	-1.5	-1.4	-1.4	-1.3	1.6	-1.5
Std. dev. reaction times	0.5	0.7	1.0	0.7	1.0	1.0	0.6	-0.3	1.0
Reaction time trials completed	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.2	0.0	-0.4
Reaction time trials AUC	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.2	-0.1	-0.3
Social response proportion	0.0	0.0	0.1	0.2	0.0	0.0	0.3	0.0	0.3
Social responses	1.6	2.0	2.7	-1.4	-1.5	-1.5	-1.2	1.6	-1.2
Social time	0.2	0.3	0.6	0.6	0.4	0.4	0.7	-0.3	0.8
Conditioned locomotion	1.0	1.2	2.3	1.1	0.8	0.8	1.5	-1.3	0.9
Cocaine response after cond. corrected	0.6	0.6	1.2	0.8	0.8	0.8	0.8	-0.1	1.1
Cocaine response after cond. not corrected	0.7	0.7	1.2	0.9	0.9	0.9	0.8	-0.4	1.1
Cocaine response before conditioning	0.0	0.0	0.1	0.0	-0.1	-0.1	0.1	-0.4	-0.1
Saline control response	0.7	1.0	2.1	-1.0	-0.7	-0.7	-1.0	1.4	-0.8
Condit. Reinf. active minus inactive responses	1.0	1.3	1.9	1.1	1.4	1.4	0.7	-0.9	1.2
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.1	0.9	1.0	1.0	0.5	-0.7	0.9
Condit. Reinf. active responses	0.2	0.3	0.4	0.5	0.7	0.7	0.3	-0.3	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.2	0.3	-0.2
Condit. Reinf. lever presses	0.5	0.7	1.5	-0.9	-0.5	-0.5	-1.1	1.2	-0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.2	0.4	0.4	0.0	-0.0	0.3
Pavlov. Cond. lever latency	0.2	0.3	1.0	0.5	0.2	0.2	0.7	-1.0	0.4
Pavlov. Cond. magazine entry latency	0.7	0.8	2.1	-0.9	-0.5	-0.5	-1.1	1.5	-0.5
Pavlov. Cond. change in total contacts	0.4	0.6	1.6	-0.8	-0.3	-0.3	-1.0	1.3	-0.5
Pavlov. Cond. index score	0.7	0.9	2.4	-0.9	-0.4	-0.4	-1.2	1.5	-0.6
Pavlov. Cond. latency score	0.6	0.8	1.9	-0.9	-0.4	-0.4	-1.1	1.4	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	1.1	-0.6	-0.2	-0.2	-0.8	1.0	-0.4
Pavlov. Cond. magazine entry number	0.8	1.0	2.4	1.0	0.6	0.6	1.3	-1.6	0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	0.7	0.4	0.4	1.0	-0.9	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	2.5	-0.9	-0.4	-0.4	-1.2	1.6	-0.6
Pavlov. Cond. response bias	0.8	1.1	2.4	-1.0	-0.7	-0.7	-1.3	1.6	-0.8
Conditioned reinforcement - actives	5.2	5.1	6.7	2.2	2.6	2.6	1.3	-2.5	2.1
Conditioned reinforcement - inactives	1.3	1.5	1.9	1.1	1.4	1.4	0.8	-1.3	1.1
Conditioned locomotion	1.9	2.3	3.4	1.4	1.8	1.8	0.3	-1.9	1.4
Intermittent access intake day 1-15 change	1.9	1.9	2.9	1.3	1.4	1.4	1.0	-1.7	1.2
Intermittent access intake escalation	2.1	2.0	3.1	1.4	1.4	1.4	1.1	-1.8	1.3
Intermittent access intake escalation 2	0.2	0.2	0.4	0.3	0.3	0.3	0.5	-0.6	0.4
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.7	0.6	0.8	0.8	0.3	-0.6	0.4
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	0.4	0.7	0.7	0.3	-0.7	0.3
Intermitt. access escalation Index	0.2	0.2	0.5	-0.4	-0.3	-0.3	-0.4	0.2	-0.7
Intermittent access day 1 total infusions	0.6	0.7	1.2	0.7	1.1	1.1	0.1	-1.0	0.7
Intermittent access day 15 total infusions	2.7	3.0	4.6	1.6	2.0	2.0	1.0	-2.1	1.5
Intermittent access terminal intake (last 3 days)	1.4	1.5	2.6	1.1	1.4	1.4	0.5	-1.6	0.9
Intermittent access total infusions	2.1	2.3	3.2	1.4	1.8	1.8	0.8	-1.8	1.3
Intermittent access day 1 locomotion	2.2	2.3	3.2	1.4	1.8	1.8	0.7	-1.8	1.4
Intermittent access day 15 total locomotion	1.8	1.9	3.1	1.2	1.4	1.4	0.9	-1.8	1.3
Intermittent access total locomotion	2.5	2.8	4.4	1.5	1.8	1.8	0.9	-2.1	1.6
Intermittent access standard deviation	4.3	4.6	5.0	2.2	2.2	2.2	2.0	-2.0	2.1
Cocaine induced anxiety	0.4	0.5	0.6	0.7	0.7	0.7	0.7	-0.7	0.6
Post-drug Anxiety	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.0	0.3	-0.1
Baseline Anxiety	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.1	0.3	-0.1
Lifetime Intake	2.4	2.7	3.6	1.6	1.9	1.9	1.0	-1.9	1.5
Incentive Sensitization - Responses	0.2	0.2	0.5	0.1	0.5	0.5	-0.1	-0.7	0.0
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	0.3	0.6	0.6	0.1	-0.9	0.2
Progressive ratio test 1 active lever presses	1.6	1.6	2.2	1.3	1.5	1.5	0.8	-1.4	1.1
Progressive ratio test 1 breakpoint	1.8	1.9	2.6	1.4	1.6	1.6	0.9	-1.5	1.2
Progressive ratio test 1 inactive lever presses	1.4	1.5	2.0	1.2	1.4	1.4	0.8	-1.3	1.2
Progressive ratio test 2 active lever presses	2.5	2.7	4.4	1.4	1.9	1.9	0.7	-2.1	1.4
Progressive ratio test 2 breakpoint	2.5	2.7	4.4	1.5	1.9	1.9	0.9	-2.1	1.4
Progressive ratio test 2 inactive lever presses	1.5	1.7	2.9	1.1	1.5	1.5	0.6	-1.7	1.0
Total sessions with >9 infusions	0.6	0.7	0.7	0.9	0.9	0.9	0.8	-0.8	0.8
Short access day 1 total inactive lever presses	5.4	6.0	6.8	2.5	2.6	2.6	2.0	-2.5	2.5
Short access day 10 total inactive lever presses	0.9	0.9	1.6	0.9	1.3	1.3	0.3	-1.1	0.6
Short access day 1 total infusions	0.9	0.9	1.2	0.9	1.1	1.1	0.7	-1.0	0.9
Short access day 10 total infusions	2.3	2.6	2.9	1.5	1.7	1.7	1.3	-1.7	1.6
Short access total infusions	3.3	3.6	3.8	1.9	1.9	1.9	1.8	-2.0	1.9
Short access day 1 locomotion	2.9	3.0	4.1	1.6	1.9	1.9	1.3	-2.0	1.5
Short access day 10 total locomotion	6.1	6.7	7.9	2.5	2.7	2.7	2.0	-2.8	2.6
Short access total locomotion	3.5	3.5	4.1	1.8	2.0	2.0	1.6	-2.0	1.8
Compulsive drug intake	2.0	2.0	2.4	-1.4	-1.3	-1.3	-1.4	1.4	-1.6
One hour access (0.3 mA shock)	0.4	0.4	0.6	0.6	0.8	0.8	0.2	-0.8	0.5
One hour access (shock baseline)	3.1	3.6	4.4	1.9	2.1	2.1	1.3	-2.1	1.9
Number of responses in last shaping day	2.3	2.3	2.6	1.5	1.6	1.6	1.3	-1.6	1.6
Context. condit. distance diff. score	0.2	0.3	0.4	-0.5	-0.6	-0.5	-0.6	0.5	-0.6
Locomotion velocity, session 1	3.5	3.7	4.3	-2.1	-1.9	-2.0	-2.0	1.5	-2.1
Locomotion distance, session 1	0.8	1.1	2.1	-1.1	-0.8	-0.8	-1.4	0.7	-1.1
Locomotion velocity, session 2	4.6	5.4	6.6	-2.4	-2.2	-2.3	-2.6	1.9	-2.4
Locomotion distance, session 2	0.1	0.1	0.3	0.1	0.5	0.5	-0.4	-0.0	0.3
Locomotion velocity, session 3	0.3	0.3	0.5	0.5	0.6	0.6	0.3	-0.4	0.7
Locomotion distance, session 3	0.4	0.4	0.9	0.6	0.6	0.5	0.8	-0.2	0.9
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	0.3	0.3	0.4	0.1	-0.6	0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.1	0.1	0.2	-0.3	-0.6	-0.2
Locomotion velocity, session 7	0.4	0.4	0.7	0.6	0.5	0.5	0.8	-0.1	0.8
Locomotion distance, session 7	0.7	0.8	1.4	0.9	1.1	1.1	0.6	-0.0	1.2
Stereotopy head waving bouts, day 7	1.0	1.2	1.6	-1.1	-1.1	-1.1	-1.1	0.6	-1.2
Stereotopy head waving duration, day 7	1.2	1.4	1.7	-1.2	-1.2	-1.2	-1.1	1.0	-1.3
Locomotion velocity, session 8	1.1	1.3	1.8	-1.1	-1.3	-1.3	-0.6	1.4	-0.9
Locomotion distance, session 8	0.1	0.1	0.4	-0.3	-0.1	-0.1	-0.6	0.4	-0.2
Degree of sensitization distance	0.6	0.6	1.1	0.8	1.0	1.0	0.4	-0.5	0.8
Degree of sensitization stereotypy	1.0	1.1	1.4	-1.1	-1.0	-1.1	-1.1	0.8	-1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.6	0.7	0.7	0.4	-0.7	0.6
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.0	0.9	0.8	0.7	0.9	-1.0	0.8
Condit. Reinf. active responses	0.3	0.3	0.5	0.5	0.7	0.7	0.4	-0.6	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.2	0.2	-0.1	0.2	0.0
Incentive salience index mean	0.7	0.8	1.1	0.9	1.0	1.0	0.6	-1.1	0.8
Condit. Reinf. lever presses	0.2	0.2	0.4	0.4	0.6	0.6	0.2	-0.7	0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.2	0.0
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.4	-0.3	-0.3	-0.4	0.6	-0.3
Total zone transitions, hab. session 1	0.6	0.8	1.3	-0.9	-0.8	-0.8	-1.2	0.4	-1.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.3	-0.2	-0.3	-0.7	-0.4	-0.6
Locomotion velocity, hab. session 1	0.2	0.2	0.6	-0.4	-0.3	-0.3	-0.8	-0.2	-0.7
Time in familiar zone, hab. session 2	1.0	1.0	1.6	1.0	1.2	1.3	0.7	-0.6	1.1
Time in novel zone, hab. session 2	0.8	0.8	1.1	-0.9	-1.0	-1.1	-0.7	0.6	-0.9
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.2	0.2	0.1	-0.6	0.5	-0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.6	0.9	0.8	0.2	-0.6	0.6
Locomotion velocity, hab. session 2	0.5	0.7	1.2	0.9	1.1	1.0	0.4	-0.8	0.8
Novel to familiar place preference ratio	0.7	0.7	0.8	0.9	0.9	0.8	0.9	-0.5	0.9
Novelty place preference	0.5	0.5	0.6	0.7	0.7	0.7	0.7	-0.5	0.7
Time in novel zone, NPP test	0.4	0.4	0.4	0.6	0.7	0.6	0.7	-0.4	0.6
Total zone transitions, NPP test	0.0	0.1	0.3	-0.1	0.1	0.1	-0.5	-0.0	-0.1
Total locomotion distance, NPP test	0.4	0.6	1.1	0.6	1.0	0.9	-0.2	-1.0	0.5
Locomotion velocity, NPP test	0.7	1.1	1.9	0.9	1.3	1.2	0.0	-1.4	0.7
Pavlov. Cond. lever latency	0.5	0.6	1.0	-0.7	-0.7	-0.7	-1.0	0.7	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.4	-0.2	-0.2	-0.6	0.4	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	0.1
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	0.4	0.3	0.3	-0.3	0.3
Pavlov. Cond. latency score	0.1	0.1	0.1	0.2	0.3	0.3	0.4	-0.3	0.3
Pavlov. Cond. lever contacts	0.5	0.6	0.9	0.7	0.7	0.6	1.0	-0.9	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.1	0.1	0.3	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	0.9	1.0	0.9	1.2	-0.3	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.4	0.5	0.5	0.3	-0.5	0.4
Pavlov. Cond. response bias	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	-0.2	0.0
Bone: apparent density	1.1	1.9	2.5	-1.4	-1.6	-1.6	-0.9	1.6	-1.0
Bone surface	1.7	3.0	3.4	-1.8	-1.6	-1.6	-1.8	1.7	-1.7
Bone volume	0.7	1.2	1.3	-1.1	-1.1	-1.1	-1.0	1.1	-0.9
Bone: connectivity density	2.8	4.4	5.2	-2.2	-2.1	-2.1	-1.8	2.3	-1.9
Bone: cortical apparent density	0.8	1.1	1.8	-0.9	-1.3	-1.3	-0.2	1.3	-0.8
Bone: cortical area	0.1	0.2	0.9	-0.3	0.1	0.2	-0.9	0.0	-0.4
Bone: cortical porosity	0.2	0.3	0.6	-0.4	-0.6	-0.6	-0.4	-0.3	-0.7
Bone: cortical porosity	1.2	1.3	2.1	-1.1	-1.2	-1.2	-1.0	0.4	-1.5
Bone: cortical thickness	0.8	1.3	1.8	1.2	1.3	1.3	0.6	-1.3	1.0
Bone: cortical thickness	0.2	0.2	0.7	0.0	0.3	0.3	-0.6	-0.8	-0.3
Bone: cortical tissue density	0.9	1.2	1.9	-1.0	-1.4	-1.4	-0.3	1.3	-0.8
Bone: elastic displacement	0.7	0.8	1.7	0.9	0.7	0.7	0.9	-1.3	0.7
Bone: elastic work	0.1	0.1	0.2	0.3	0.3	0.4	0.1	-0.5	0.3
Bone: endosteal estimation	1.9	4.1	7.5	-2.2	-1.5	-1.5	-2.7	1.5	-2.3
Bone: endosteal perimeter	1.2	2.4	4.4	-1.7	-1.1	-1.1	-2.1	1.5	-1.7
Bone: final force	0.5	0.9	1.6	-1.0	-0.8	-0.7	-1.2	0.7	-1.1
Bone: final moment	0.4	0.7	1.3	-0.9	-0.6	-0.6	-1.1	0.6	-0.9
Bone: marrow area	1.6	3.5	6.9	-2.0	-1.4	-1.4	-2.6	1.3	-2.2
Bone: maximum diameter	0.5	0.9	2.2	-1.0	-0.6	-0.6	-1.5	0.4	-1.2
Bone: maximum force	0.7	1.2	1.9	-1.2	-0.9	-0.9	-1.4	1.0	-1.2
Bone: maximum moment	0.6	1.0	1.6	-1.1	-0.8	-0.8	-1.3	0.9	-1.0
Bone: minimum diameter	0.5	0.9	2.7	-0.9	-0.3	-0.3	-1.6	0.8	-0.9
Bone: periosteal estimation	0.9	1.9	4.7	-1.4	-0.8	-0.8	-2.2	0.8	-1.6
Bone: periosteal perimeter	1.1	1.7	4.0	-1.4	-0.8	-0.8	-2.0	1.0	-1.5
Bone: post-yield work	2.2	3.0	3.5	-1.9	-1.6	-1.6	-1.7	1.9	-1.8
Bone: stiffness	0.6	0.9	1.2	-1.0	-0.8	-0.9	-1.1	0.8	-1.0
Bone: tissue strength	0.1	0.1	0.5	-0.1	-0.0	-0.0	-0.1	0.7	0.1
Bone: trabecular number	2.6	4.1	5.2	-2.1	-2.2	-2.2	-1.5	2.3	-1.7
Bone: trabecular spacing	1.9	2.5	4.2	1.7	1.5	1.5	1.3	-2.1	1.2
Bone: trabecular thickness	0.3	0.3	1.3	-0.5	-0.5	-0.4	-0.2	1.1	-0.0
Bone: trabecular tissue density	1.5	2.1	2.5	1.6	1.4	1.4	1.5	-1.3	1.4
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.4	0.3	0.2	0.4	-0.7	0.3
Distance traveled before self-admin	1.1	1.2	1.3	1.1	1.1	1.1	1.0	-1.1	1.1
Distance traveled after self-admin	3.3	3.6	4.2	2.0	2.1	2.0	1.8	-1.9	1.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	-0.5	-0.4	-0.3	-0.9	0.4	-0.2
Delta time in open arm before/after self-admin	0.6	0.5	0.8	-0.7	-0.9	-0.8	-0.5	0.6	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.1	0.3	0.3	-0.6	-0.4	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.4	0.1	-0.6
Active lever presses in extinction session 6	3.2	3.0	3.6	1.8	1.8	1.7	1.6	-1.9	1.6
Delta distance traveled before/after self-admin	1.0	1.0	1.4	1.1	1.2	1.2	0.9	-1.1	0.6
Delta ambulatory time before/after self-admin	2.1	2.3	2.7	1.6	1.6	1.6	1.5	-1.6	1.1
Time in closed arm before self-admin	0.1	0.1	0.1	0.2	0.3	0.2	0.3	-0.3	0.1
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.1	0.2
Time in open arm before self-admin	0.1	0.2	0.3	-0.4	-0.4	-0.5	-0.3	0.6	-0.1
Time in open arm after self-admin	0.3	0.3	0.7	-0.6	-0.5	-0.5	-0.8	0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.3	0.9	0.5	0.4	1.1	-0.6	0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	0.4	0.5	0.4	-0.5	0.2
Time to tail flick, vehicle, after self-admin	1.2	1.3	1.4	1.2	1.1	1.2	1.1	-1.1	1.0
Time to tail flick, test, before self-admin	0.1	0.1	0.6	0.2	0.3	0.2	-0.2	-0.8	0.3
Time to tail flick, test, after self-admin	3.3	3.3	4.8	1.9	1.9	1.9	1.6	-1.4	2.2
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	2.4	1.4	1.3	1.4	1.5	-1.5	1.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	0.6	0.4	0.5	0.7	0.3	0.7
Ambulatory time before self-admin	0.4	0.4	0.6	0.7	0.6	0.6	0.6	-0.8	0.6
Ambulatory time after self-admin	2.7	2.9	3.5	1.9	1.7	1.7	1.9	-1.6	1.5
Total heroin consumption	0.1	0.1	0.3	-0.3	-0.6	-0.6	0.1	0.3	-0.0
Area under the delay curve	0.1	0.1	0.3	0.2	-0.0	-0.0	0.6	-0.0	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.1	0.3	-0.4
Delay disc. indifference point, 16s delay	1.0	1.0	1.2	1.0	1.0	1.0	1.1	-0.9	1.1
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	-0.1	-0.1	0.3	-0.0	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.2	-0.1	-0.1	0.6	-0.1	0.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	-0.0	-0.1
Delay disc. indifference point, 8s delay	0.5	0.5	1.1	0.6	0.4	0.4	1.0	-0.4	0.9
Delay discount exponential model param	0.0	0.0	0.2	-0.0	0.2	0.2	-0.4	-0.1	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.0	0.3	-0.0
Change in fecal boli incidents, locomotor task	0.6	0.5	0.8	-0.8	-0.9	-0.9	-0.4	0.6	-0.7
Time >=10cm from walls, locomotor time 1	1.3	1.3	2.1	-1.2	-1.0	-1.0	-1.4	1.1	-1.0
Bouts of movement, locomotor time 1	2.2	2.4	4.5	-1.6	-1.3	-1.3	-2.1	1.2	-1.6
Total resting periods, locomotor time 1	2.6	2.9	4.7	-1.8	-1.5	-1.5	-2.2	1.4	-1.7
Rest time, locomotor task time 1	1.4	1.6	2.7	-1.4	-1.1	-1.1	-1.6	1.1	-1.2
Distance moved, locomotor task time 1	1.2	1.3	1.9	1.2	1.2	1.2	1.1	-1.4	0.8
Vertical activity count, locomotor time 1	1.9	2.0	2.3	1.5	1.5	1.5	1.2	-1.5	1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.2	0.4	0.4	-0.1	-0.3	0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.4	0.3	0.2	0.2	0.2	-0.5	0.6
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.2	0.1	0.1	0.1	-0.3	0.4
Rest time, locomotor task time 2	0.5	0.5	1.3	-0.7	-0.7	-0.7	-0.4	1.1	-0.5
Distance moved, locomotor task time 2	2.5	2.9	5.1	1.6	1.9	1.9	0.9	-2.3	1.3
Vertical activity count, locomotor time 2	2.9	3.2	4.5	1.7	2.1	2.1	0.7	-2.1	1.5
Weight adjusted by age	0.1	0.1	0.2	0.4	0.4	0.4	0.2	-0.4	0.3
Seeking ratio, delayed vs. immediate footshock	2.7	3.1	3.4	1.8	1.8	1.8	1.8	-1.7	1.8
Locomotion in novel chamber	3.0	3.7	4.3	1.9	2.0	2.0	1.6	-2.1	2.0
Locomotion in novel chamber post-restriction	0.3	0.4	0.6	0.5	0.8	0.7	0.0	-0.8	0.4
Progressive ratio	0.5	0.6	1.4	0.8	0.5	0.5	1.2	-0.7	0.6
Food seeking constrained by brief footshock	1.6	2.0	2.2	-1.5	-1.4	-1.4	-1.3	1.3	-1.5
Seeking ratio, punishment vs. effort	2.8	3.4	4.9	-2.0	-1.6	-1.7	-2.2	1.7	-1.8
Run reversals in cocaine runway, females	1.7	1.7	2.1	-1.3	-1.4	-1.4	-1.0	1.4	-1.2
Run reversals in cocaine runway, males	5.4	5.2	5.9	2.4	2.3	2.3	2.0	-2.3	2.4
Latency to leave start box in cocaine runway	1.7	1.8	2.0	1.4	1.4	1.3	1.1	-1.4	1.4
Latency to leave start box in cocaine runway, F	3.4	3.7	4.2	2.0	2.0	1.9	1.8	-1.9	2.0
Latency to leave start box in cocaine runway, M	0.5	0.4	0.6	-0.8	-0.6	-0.6	-0.8	0.5	-0.6
Cd content in liver	0.3	0.4	0.5	-0.5	-0.7	-0.7	-0.4	0.7	-0.5
Co content in liver	0.5	0.6	1.1	-0.8	-0.6	-0.6	-1.1	0.6	-0.9
Cu content in liver	0.2	0.2	0.4	0.2	0.3	0.3	0.6	0.6	0.6
Fe content in liver	0.2	0.3	1.3	0.4	-0.2	-0.2	1.1	-0.3	0.4
K content in liver	0.5	0.5	1.9	-0.6	-0.3	-0.3	-0.6	1.4	-0.2
Mg content in liver	0.6	0.6	1.1	0.7	0.8	0.8	0.9	0.3	1.1
Mn content in liver	0.4	0.5	0.9	0.7	0.6	0.6	0.8	-1.0	0.6
Na content in liver	1.1	1.1	2.1	-1.0	-0.8	-0.8	-1.2	1.4	-0.9
Rb content in liver	0.2	0.3	1.0	0.2	-0.2	-0.2	1.0	0.5	0.4
Se content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.5	0.4	-0.3
Sr content in liver	0.0	0.0	0.1	-0.0	0.1	0.1	-0.3	-0.2	-0.2
Zn content in liver	0.7	0.8	2.4	-0.9	-0.7	-0.7	-0.6	1.5	-0.6