Hub : Genes

ENSRNOG00000022871

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000022871	0.21	0.11	0.0e+00	0.17	0.19	0.19	0.18	5.8e-19	6.0e-21	2.2e-20	4.4e-20
2	Liver	gene expression	ENSRNOG00000022871	0.02	0.02	4.3e-03	0.01	0.02	0.01	0.01	3.7e-02	4.9e-03	5.6e-02	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	5.6	18.3	20.8	4.0	-4.6
BMI without tail	1.3	2.8	3.5	1.4	-1.9
Body weight	0.9	3.7	4.3	1.8	-2.1
Epididymis fat weight	0.2	0.5	0.6	-0.7	0.8
Glucose	1.6	2.4	2.8	1.4	-1.7
Heart weight	0.0	0.0	0.0	-0.2	0.2
Left kidney weight	0.0	0.0	0.0	0.2	0.0
Right kidney weight	0.9	2.6	3.1	-1.5	1.7
Tail length	3.4	10.4	11.0	-3.1	3.3
Length with tail	1.7	6.1	6.9	-2.3	2.6
Length without tail	0.0	0.0	0.0	0.0	0.2
Liver weight, left	1.7	2.7	3.0	1.6	-1.7
Liver weight, right	1.5	2.5	2.7	1.7	-1.5
Parametrial fat weight	0.4	0.7	0.8	-0.8	0.9
Retroperitoneal fat weight	0.2	0.6	0.7	0.7	-0.8
Intraocular pressure	0.1	0.1	0.1	-0.4	0.0
Extensor digitorum longus weight	2.8	11.3	13.5	3.0	-3.7
Soleus weight	8.3	24.3	26.4	4.7	-5.1
Tibialis anterior weight	0.6	2.2	2.6	1.3	-1.6
Tibia length	0.9	2.6	2.7	-1.5	1.7
Number of licking bursts	0.1	0.1	0.2	-0.4	0.0
Food consumed during 24 hour testing period	0.4	0.4	0.6	0.5	-0.8
Times rat made contact with spout	0.0	0.0	0.1	-0.1	-0.3
Mean time between licks in bursts	4.5	6.2	6.3	-2.5	2.5
Mean num. licks in bursts	0.1	0.1	0.1	0.3	-0.2
Std. dev. time between licks in bursts	0.6	0.8	0.9	-0.8	1.0
Water consumed over 24 hours	0.6	0.7	0.8	0.8	-0.9
Indifference point 0 sec	0.3	0.5	0.5	0.7	-0.7
Indifference point AUC	0.6	0.7	0.7	-0.8	0.8
Indifference point function ln k	0.1	0.2	0.3	0.3	-0.5
Indifference point function log k	0.1	0.2	0.3	0.3	-0.5
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	0.4	-0.5
Delay discounting total patch changes 12 sec	0.3	0.4	0.5	0.6	-0.7
Delay discounting total patch changes 18 sec	0.8	1.0	1.2	-0.9	1.1
Delay discounting total patch changes 24 sec	0.0	0.0	0.0	0.1	0.1
Delay discounting total patch changes 6 sec	0.0	0.0	0.0	0.1	0.1
Delay discounting time to switch 0 sec	1.4	2.1	2.7	1.7	-1.2
Delay discounting water rate 0 sec	0.3	0.5	0.8	-0.9	0.3
Delay discounting water rate 12 sec	0.4	0.5	0.9	0.4	-1.0
Delay discounting water rate 18 sec	0.7	0.9	1.5	-1.2	0.5
Delay discounting water rate 24 sec	0.1	0.1	0.2	-0.5	-0.2
Delay discounting water rate 6 sec	0.7	1.0	1.4	-1.2	0.8
Locomotor activity	2.0	3.2	4.2	-1.5	2.1
Locomotor testing distance	1.0	1.6	2.1	-1.0	1.5
Locomotor testing rearing	0.1	0.1	0.2	-0.4	0.3
Light reinforcement 1	5.7	10.4	11.5	-3.0	3.4
Light reinforcement 2	1.7	2.2	2.4	-1.4	1.6
Reaction time number correct	0.1	0.1	0.2	-0.1	-0.4
Reaction time mean minus median	0.6	0.8	0.9	-0.9	0.9
Reaction time mean minus median AUC	0.0	0.0	0.0	0.1	0.0
Reaction time num false alarms	0.0	0.1	0.1	-0.3	-0.0
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.3	-0.0
Reaction time trials correct on left	0.1	0.1	0.2	-0.1	-0.4
Reaction time trials on left	0.1	0.1	0.2	-0.1	-0.5
Reaction time mean	0.1	0.2	0.2	0.5	-0.3
Reaction time mean AUC	0.2	0.3	0.4	0.6	-0.5
Median of all reaction times	0.6	0.8	0.9	1.0	-0.8
Reaction time omissions	0.0	0.0	0.0	0.0	0.1
Reaction time false alarm rate	0.0	0.0	0.0	-0.0	-0.0
Reaction time premature initiation rate	0.9	1.2	1.3	-1.1	1.1
Reaction time premature initiations	0.9	1.3	1.7	-1.3	1.0
Std. dev. reaction times	0.1	0.1	0.1	-0.3	0.4
Reaction time trials completed	0.1	0.1	0.2	-0.1	-0.5
Reaction time trials AUC	0.1	0.1	0.2	-0.2	-0.4
Social response proportion	0.2	0.3	0.4	-0.3	0.6
Social responses	5.3	6.8	8.2	-2.3	2.9
Social time	0.9	1.2	1.4	1.2	-1.0
Conditioned locomotion	0.6	0.7	1.0	0.6	-1.0
Cocaine response after cond. corrected	3.6	4.0	5.5	1.6	-2.3
Cocaine response after cond. not corrected	3.5	3.9	5.4	1.6	-2.3
Cocaine response before conditioning	0.6	0.8	1.0	-0.8	1.0
Saline control response	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. active minus inactive responses	2.1	2.6	2.9	-1.7	1.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	-0.2
Condit. Reinf. active responses	2.0	2.8	3.0	-1.7	1.6
Condit. Reinf. inactive responses	1.8	2.3	2.4	-1.5	1.5
Condit. Reinf. lever presses	2.2	3.0	3.0	-1.7	1.7
Condit. Reinf. lever reinforcers received	1.6	2.3	2.5	-1.6	1.4
Pavlov. Cond. lever latency	0.5	0.6	0.7	0.8	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.7	0.8	-0.9	0.9
Pavlov. Cond. change in total contacts	0.3	0.5	0.5	-0.7	0.7
Pavlov. Cond. index score	0.7	0.9	0.9	-1.0	0.9
Pavlov. Cond. latency score	0.5	0.7	0.7	-0.8	0.8
Pavlov. Cond. lever contacts	0.6	0.9	1.0	-1.0	0.9
Pavlov. Cond. magazine entry number	0.9	1.1	1.2	1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	0.9	-0.9	1.0
Pavlov. Cond. response bias	1.7	2.3	2.5	-1.6	1.5
Conditioned reinforcement - actives	1.9	1.9	1.9	-1.4	1.4
Conditioned reinforcement - inactives	0.1	0.1	0.1	0.1	-0.4
Conditioned locomotion	6.9	8.3	8.7	-2.8	3.0
Intermittent access intake day 1-15 change	5.2	5.2	5.7	-2.2	2.4
Intermittent access intake escalation	5.3	5.2	5.4	-2.2	2.3
Intermittent access intake escalation 2	5.6	5.6	6.0	-2.3	2.5
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.2	-0.4	0.4
Intermitt. access day 15 inactive lever presses	0.8	0.9	0.9	-0.9	1.0
Intermitt. access escalation Index	0.3	0.3	0.4	0.7	-0.4
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	0.0
Intermittent access day 15 total infusions	2.8	3.1	3.4	-1.9	1.7
Intermittent access terminal intake (last 3 days)	1.5	1.6	1.7	-1.3	1.2
Intermittent access total infusions	0.6	0.7	0.9	-1.0	0.7
Intermittent access day 1 locomotion	0.9	0.9	1.1	-1.0	0.9
Intermittent access day 15 total locomotion	4.5	4.8	4.8	-2.2	2.2
Intermittent access total locomotion	1.3	1.4	1.5	-1.2	1.2
Intermittent access standard deviation	3.0	3.2	3.4	-1.8	1.8
Cocaine induced anxiety	0.1	0.1	0.2	-0.1	0.4
Post-drug Anxiety	0.2	0.2	0.3	-0.3	0.5
Baseline Anxiety	0.5	0.5	0.6	-0.8	0.7
Lifetime Intake	0.4	0.4	0.6	-0.8	0.5
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.2	0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.7	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.6	0.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.4
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	-0.8	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	-0.6	0.5
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.3	0.2
Total sessions with >9 infusions	0.0	0.0	0.0	0.1	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	0.4
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.1	-0.1
Short access day 1 total infusions	0.1	0.1	0.1	-0.3	0.4
Short access day 10 total infusions	0.7	0.8	1.1	-1.0	0.7
Short access total infusions	0.0	0.0	0.1	-0.2	0.1
Short access day 1 locomotion	0.6	0.7	0.9	-0.7	0.9
Short access day 10 total locomotion	3.9	4.2	4.4	-2.0	2.1
Short access total locomotion	0.9	0.9	1.0	-0.9	1.0
Compulsive drug intake	1.7	1.7	1.8	1.3	-1.3
One hour access (0.3 mA shock)	0.0	0.1	0.1	-0.3	-0.1
One hour access (shock baseline)	0.8	0.9	1.3	-1.1	0.7
Number of responses in last shaping day	0.1	0.1	0.2	-0.3	0.4
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	-0.0
Locomotion velocity, session 1	0.1	0.1	0.1	-0.0	0.4
Locomotion distance, session 1	0.1	0.1	0.1	0.3	0.4
Locomotion velocity, session 2	3.1	3.6	4.9	-1.5	2.2
Locomotion distance, session 2	0.3	0.4	0.8	-0.2	0.9
Locomotion velocity, session 3	8.3	9.6	9.9	-3.1	3.2
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.3
Stereotopy head waving bouts, day 3	5.7	6.9	7.8	-2.4	2.8
Stereotopy head waving duration, day 3	6.5	7.9	8.7	-2.7	3.0
Locomotion velocity, session 7	1.7	1.9	2.0	-1.4	1.3
Locomotion distance, session 7	0.0	0.1	0.1	-0.3	-0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.2	0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.1	0.4
Locomotion velocity, session 8	0.6	0.8	1.1	-0.6	1.1
Locomotion distance, session 8	0.2	0.3	0.4	-0.3	0.7
Degree of sensitization distance	0.2	0.2	0.3	0.4	-0.5
Degree of sensitization stereotypy	2.5	2.7	3.1	1.7	-1.5
Condit. Reinf. active minus inactive responses	5.2	5.8	6.1	-2.4	2.5
Condit. Reinf. active-inactive response ratio	2.2	2.4	2.5	-1.6	1.5
Condit. Reinf. active responses	3.3	4.0	4.8	-1.8	2.2
Condit. Reinf. inactive responses	0.4	0.4	0.7	-0.4	0.8
Incentive salience index mean	2.4	2.9	3.4	-1.6	1.9
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	-0.2
Time in familiar zone, hab. session 1	2.6	2.5	2.8	-1.7	1.5
Time in novel zone, hab. session 1	1.6	1.5	1.8	1.3	-1.2
Total zone transitions, hab. session 1	0.5	0.7	1.0	-0.6	1.0
Total locomotion distance, hab. session 1	0.7	1.0	1.6	-0.7	1.2
Locomotion velocity, hab. session 1	1.2	1.8	2.5	-1.0	1.6
Time in familiar zone, hab. session 2	6.8	7.1	7.5	-2.7	2.6
Time in novel zone, hab. session 2	5.5	5.5	5.7	2.4	-2.3
Total zone transitions, hab. session 2	0.6	0.7	1.1	1.1	-0.6
Total locomotion distance, hab. session 2	0.4	0.6	0.9	-0.5	1.0
Locomotion velocity, hab. session 2	0.3	0.5	0.8	-0.3	0.9
Novel to familiar place preference ratio	5.6	5.9	6.3	2.5	-2.3
Novelty place preference	3.6	3.7	4.0	2.0	-1.9
Time in novel zone, NPP test	3.6	3.8	4.0	2.0	-1.9
Total zone transitions, NPP test	0.2	0.3	0.5	0.7	-0.3
Total locomotion distance, NPP test	0.1	0.2	0.3	0.5	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	0.4	0.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.0	-0.3
Pavlov. Cond. magazine entry latency	4.8	6.2	6.4	-2.4	2.5
Pavlov. Cond. change in total contacts	0.5	0.5	0.6	-0.7	0.8
Pavlov. Cond. index score	1.0	1.3	1.6	-1.0	1.3
Pavlov. Cond. latency score	0.9	1.1	1.5	-0.9	1.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.1	0.5
Pavlov. Cond. magazine entry number	1.5	1.9	2.1	1.3	-1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.3	-1.2	1.5
Pavlov. Cond. response bias	2.2	2.7	2.9	-1.6	1.7
Bone: apparent density	0.8	1.3	1.8	1.3	-0.9
Bone surface	0.4	0.7	1.4	1.2	-0.4
Bone volume	0.5	0.9	1.5	1.2	-0.5
Bone: connectivity density	1.0	1.5	2.0	1.4	-1.0
Bone: cortical apparent density	1.4	1.9	2.1	1.3	-1.4
Bone: cortical area	0.7	1.0	1.1	1.1	-1.0
Bone: cortical porosity	0.2	0.2	0.3	-0.4	0.5
Bone: cortical porosity	0.0	0.1	0.1	0.3	-0.0
Bone: cortical thickness	1.4	2.3	2.3	1.5	-1.5
Bone: cortical thickness	0.1	0.1	0.2	-0.4	0.0
Bone: cortical tissue density	1.1	1.4	1.6	1.1	-1.3
Bone: elastic displacement	0.0	0.0	0.0	0.1	0.1
Bone: elastic work	0.6	0.7	0.8	0.8	-0.9
Bone: endosteal estimation	0.1	0.1	0.1	0.3	-0.4
Bone: endosteal perimeter	0.2	0.4	0.6	-0.5	0.7
Bone: final force	1.1	1.8	1.9	1.3	-1.4
Bone: final moment	0.9	1.5	1.6	1.2	-1.3
Bone: marrow area	0.1	0.1	0.1	0.3	-0.4
Bone: maximum diameter	0.4	0.8	1.0	-0.7	1.0
Bone: maximum force	1.0	1.7	1.9	1.2	-1.4
Bone: maximum moment	0.8	1.4	1.6	1.1	-1.3
Bone: minimum diameter	0.0	0.0	0.1	-0.2	0.2
Bone: periosteal estimation	0.3	0.5	0.6	0.8	-0.7
Bone: periosteal perimeter	0.0	0.0	0.0	0.0	0.2
Bone: post-yield work	0.0	0.0	0.1	0.1	-0.3
Bone: stiffness	2.0	3.1	3.4	1.7	-1.8
Bone: tissue strength	2.2	2.2	2.3	1.5	-1.4
Bone: trabecular number	0.1	0.2	0.4	-0.3	0.6
Bone: trabecular spacing	0.1	0.1	0.1	-0.4	-0.2
Bone: trabecular thickness	1.5	1.9	2.7	1.7	-1.0
Bone: trabecular tissue density	0.8	1.2	1.5	0.9	-1.2
Breakpoint value in progressive ratio session	5.9	6.6	6.7	-2.6	2.6
Distance traveled before self-admin	1.4	1.5	1.7	1.3	-1.1
Distance traveled after self-admin	0.2	0.2	0.2	-0.3	0.5
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.3	-0.7
Delta time in open arm before/after self-admin	1.6	1.5	1.6	1.2	-1.3
Diff in mean of infusions in LGA sessions	2.0	2.2	2.4	-1.4	1.6
Extinction: sum of active levers before priming	1.9	1.9	2.1	-1.4	1.3
Active lever presses in extinction session 6	1.4	1.4	1.6	-1.1	1.3
Delta distance traveled before/after self-admin	2.1	2.3	2.5	-1.4	1.6
Delta ambulatory time before/after self-admin	2.3	2.5	2.7	-1.5	1.6
Time in closed arm before self-admin	1.5	1.8	2.2	1.5	-1.1
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	-0.1
Time in open arm before self-admin	1.4	1.5	1.6	-1.3	1.2
Time in open arm after self-admin	0.6	0.6	0.9	0.6	-0.9
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.5	-0.6	0.7
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.2	-0.5	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.0	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.3	0.4	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	0.4
Ambulatory time before self-admin	1.3	1.4	1.5	1.2	-1.1
Ambulatory time after self-admin	0.0	0.1	0.1	-0.1	0.3
Total heroin consumption	1.8	2.1	2.3	-1.4	1.5
Area under the delay curve	1.5	1.6	1.9	1.1	-1.4
Delay disc. indifference point, 0s delay	8.8	9.6	10.3	3.2	-3.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	0.0	-0.2
Delay disc. indifference point, 2s delay	4.8	5.4	5.6	2.3	-2.4
Delay disc. indifference point, 24s delay	0.4	0.4	0.7	0.4	-0.8
Delay disc. indifference point, 4s delay	0.4	0.5	0.6	0.6	-0.8
Delay disc. indifference point, 8s delay	0.6	0.6	0.9	0.6	-0.9
Delay discount exponential model param	1.2	1.3	1.7	-1.0	1.3
Delay discount hyperbolic model param	1.9	2.1	2.5	-1.3	1.6
Fecal boli incidents, locomotor time 1	1.2	1.3	1.5	1.1	-1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.2	0.4
Time >=10cm from walls, locomotor time 1	2.2	2.3	2.7	1.6	-1.4
Bouts of movement, locomotor time 1	0.9	1.0	1.1	-1.1	0.9
Total resting periods, locomotor time 1	0.8	0.9	1.0	-1.0	0.9
Rest time, locomotor task time 1	0.8	0.9	1.0	-0.9	1.0
Distance moved, locomotor task time 1	2.3	2.5	2.9	1.7	-1.4
Vertical activity count, locomotor time 1	0.7	0.7	0.8	0.7	-0.9
Time >=10cm from walls, locomotor time 2	1.6	1.7	1.8	1.3	-1.3
Bouts of movement, locomotor time 2	0.3	0.3	0.4	-0.5	0.6
Total resting periods, locomotor time 2	0.3	0.3	0.4	-0.4	0.6
Rest time, locomotor task time 2	0.4	0.5	0.5	-0.7	0.7
Distance moved, locomotor task time 2	0.6	0.7	0.8	0.9	-0.8
Vertical activity count, locomotor time 2	0.4	0.4	0.5	0.5	-0.7
Weight adjusted by age	0.2	0.3	0.4	0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	4.6	5.3	5.4	-2.3	2.3
Locomotion in novel chamber	0.1	0.1	0.1	-0.4	0.2
Locomotion in novel chamber post-restriction	1.8	2.2	2.3	-1.5	1.4
Progressive ratio	0.0	0.0	0.1	0.2	-0.2
Food seeking constrained by brief footshock	0.5	0.6	0.8	-0.7	0.9
Seeking ratio, punishment vs. effort	0.2	0.3	0.3	-0.5	0.6
Run reversals in cocaine runway, females	0.4	0.4	0.4	-0.6	0.7
Run reversals in cocaine runway, males	1.2	1.2	1.4	-1.0	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	0.1
Latency to leave start box in cocaine runway, F	1.2	1.3	1.7	1.3	-1.0
Latency to leave start box in cocaine runway, M	2.8	2.7	2.7	-1.6	1.6
Cd content in liver	0.3	0.3	0.4	0.5	-0.6
Co content in liver	0.9	1.1	1.2	-1.1	1.0
Cu content in liver	0.1	0.1	0.2	0.4	-0.3
Fe content in liver	0.4	0.5	0.6	-0.7	0.7
K content in liver	0.0	0.0	0.1	0.0	0.3
Mg content in liver	0.0	0.0	0.1	0.3	0.0
Mn content in liver	0.6	0.7	1.1	-0.5	1.1
Na content in liver	0.5	0.6	0.8	0.9	-0.6
Rb content in liver	0.6	0.7	0.9	1.0	-0.8
Se content in liver	0.9	1.0	1.1	-1.0	1.1
Sr content in liver	0.2	0.2	0.3	-0.5	0.2
Zn content in liver	2.4	2.6	3.2	-1.8	1.4