Hub : Genes

Pnpla3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000022268 0.41 0.15 0.0e+00 0.2 0.02 0.22 0.07 4.3e-22 2.0e-03 1.3e-23 6.0e-08
2 Adipose mRNA stability ENSRNOG00000022268 0.06 0.04 1.5e-06 0.05 0 0.04 0.01 3.7e-06 9.5e-02 5.9e-05 1.3e-02
3 BLA gene expression ENSRNOG00000022268 0.12 0.08 4.5e-03 0.05 0.01 0.01 0.04 1.5e-03 4.9e-02 4.9e-02 4.2e-03
4 BLA mRNA stability ENSRNOG00000022268 0.06 0.04 2.4e-03 0.01 0.02 0.02 0.01 7.9e-02 2.2e-02 3.6e-02 8.4e-02
5 Brain mRNA stability ENSRNOG00000022268 0.06 0.03 1.4e-06 0.06 0.04 0.07 0.04 1.5e-06 4.5e-05 6.8e-07 2.8e-04
6 Eye gene expression ENSRNOG00000022268 0.6 0.17 3.4e-07 0.28 0.24 0.21 0.28 3.5e-05 1.3e-04 4.4e-04 3.3e-05
7 IL gene expression ENSRNOG00000022268 0.14 0.09 3.6e-03 0.07 0.06 0.02 0.05 7.2e-03 1.2e-02 8.7e-02 2.6e-02
8 Liver gene expression ENSRNOG00000022268 0.06 0.04 4.1e-04 0.02 0.01 0.01 0 3.3e-03 1.7e-02 1.3e-02 3.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail1.96.37.32.42.5-2.12.52.72.6-2.7-2.5
BMI without tail1.32.84.61.51.50.62.02.21.5-1.6-1.9
Body weight1.04.35.91.82.1-1.02.32.32.2-2.2-2.4
Epididymis fat weight0.41.01.40.81.1-0.61.11.21.1-0.9-1.1
Glucose1.82.74.0-1.8-1.70.3-1.8-2.0-1.61.61.8
Heart weight0.10.20.4-0.20.5-0.60.60.50.5-0.3-0.2
Left kidney weight14.942.752.06.36.8-4.26.97.16.8-6.6-7.2
Right kidney weight15.945.352.56.57.0-4.87.07.27.1-6.8-6.9
Tail length0.10.31.6-0.3-0.31.3-0.2-0.2-0.30.2-0.0
Length with tail0.00.10.40.20.40.30.30.20.4-0.3-0.7
Length without tail0.51.13.81.01.0-2.00.40.41.0-0.9-0.8
Liver weight, left0.20.40.80.60.6-0.90.30.50.5-0.6-0.6
Liver weight, right0.00.10.10.10.30.30.30.20.2-0.1-0.4
Parametrial fat weight0.00.10.20.50.3-0.4-0.3-0.10.0-0.30.1
Retroperitoneal fat weight1.23.85.62.02.2-1.21.82.01.9-2.1-2.4
Intraocular pressure0.10.10.2-0.30.20.50.40.20.10.1-0.1
Extensor digitorum longus weight0.20.81.30.90.80.51.01.10.7-0.8-1.1
Soleus weight0.20.62.30.60.6-1.50.40.30.7-0.6-0.8
Tibialis anterior weight0.00.00.20.50.10.0-0.3-0.20.10.0-0.2
Tibia length0.20.71.10.60.7-0.81.01.01.1-0.8-0.6
Number of licking bursts1.11.32.2-1.5-1.21.3-0.7-0.8-1.31.21.1
Food consumed during 24 hour testing period2.22.75.11.31.6-2.31.51.51.6-1.7-1.4
Times rat made contact with spout0.91.12.60.81.0-1.60.90.91.0-1.1-0.6
Mean time between licks in bursts2.63.75.1-2.3-2.01.6-1.6-1.9-1.92.01.8
Mean num. licks in bursts3.34.06.72.12.0-2.61.51.62.2-2.1-1.7
Std. dev. time between licks in bursts0.40.50.8-0.6-0.70.2-0.9-0.9-0.90.80.3
Water consumed over 24 hours2.52.93.61.41.8-1.71.91.91.9-1.8-1.2
Indifference point 0 sec0.10.10.2-0.1-0.30.0-0.4-0.4-0.20.40.2
Indifference point AUC0.10.20.4-0.0-0.2-0.6-0.6-0.5-0.30.20.4
Indifference point function ln k1.01.52.41.11.20.31.61.41.3-1.2-1.3
Indifference point function log k1.01.52.41.11.20.31.61.41.3-1.2-1.3
Delay discounting total patch changes 0 sec0.10.20.4-0.4-0.50.3-0.6-0.5-0.40.60.4
Delay discounting total patch changes 12 sec0.10.21.20.10.1-1.1-0.1-0.00.1-0.1-0.4
Delay discounting total patch changes 18 sec0.40.61.5-0.6-0.6-0.3-0.9-0.9-0.60.61.2
Delay discounting total patch changes 24 sec0.10.10.20.40.10.40.20.30.2-0.2-0.0
Delay discounting total patch changes 6 sec0.30.50.8-0.6-0.6-0.9-0.7-0.7-0.40.60.7
Delay discounting time to switch 0 sec0.10.10.30.60.20.50.00.20.2-0.1-0.3
Delay discounting water rate 0 sec0.20.30.60.20.4-0.30.80.60.6-0.5-0.4
Delay discounting water rate 12 sec0.50.81.80.50.61.01.41.20.8-0.8-0.2
Delay discounting water rate 18 sec0.10.10.4-0.4-0.30.1-0.1-0.1-0.10.00.7
Delay discounting water rate 24 sec1.41.92.71.31.4-0.61.61.71.5-1.5-1.3
Delay discounting water rate 6 sec0.20.30.6-0.6-0.50.8-0.3-0.5-0.50.50.7
Locomotor activity1.21.83.21.01.4-0.61.81.71.5-1.5-1.1
Locomotor testing distance0.00.00.1-0.3-0.10.3-0.0-0.1-0.10.10.4
Locomotor testing rearing0.10.20.50.10.30.20.70.70.4-0.3-0.5
Light reinforcement 11.12.03.21.61.60.21.61.81.5-1.5-0.7
Light reinforcement 21.52.02.91.51.50.61.61.71.3-1.3-1.4
Reaction time number correct1.21.72.6-1.4-1.61.3-1.2-1.1-1.41.31.0
Reaction time mean minus median0.00.10.2-0.4-0.0-0.30.0-0.1-0.10.3-0.1
Reaction time mean minus median AUC0.20.31.00.10.4-0.30.70.60.4-0.2-1.0
Reaction time num false alarms0.81.02.1-1.4-1.10.8-0.5-0.6-1.00.81.4
Reaction time num false alarms AUC0.40.61.5-1.1-0.80.5-0.4-0.4-0.70.51.2
Reaction time trials correct on left1.21.72.6-1.4-1.61.3-1.2-1.1-1.41.31.0
Reaction time trials on left1.31.82.7-1.5-1.71.3-1.2-1.2-1.51.31.1
Reaction time mean0.40.51.0-0.7-0.4-0.2-0.8-1.0-0.71.00.5
Reaction time mean AUC0.40.51.0-0.7-0.4-0.2-0.8-1.0-0.71.00.4
Median of all reaction times0.60.81.4-0.8-0.5-0.3-1.1-1.2-0.81.20.8
Reaction time omissions1.11.52.5-1.6-1.40.4-1.2-1.3-1.31.40.7
Reaction time false alarm rate0.10.10.4-0.5-0.1-0.10.20.1-0.1-0.00.7
Reaction time premature initiation rate0.91.23.31.20.9-1.80.30.50.8-0.9-1.4
Reaction time premature initiations0.20.31.20.40.1-1.1-0.3-0.10.1-0.2-0.8
Std. dev. reaction times0.10.10.2-0.30.0-0.4-0.2-0.3-0.20.4-0.1
Reaction time trials completed1.31.82.7-1.5-1.71.3-1.2-1.2-1.51.31.1
Reaction time trials AUC0.91.31.9-1.2-1.41.2-1.0-0.9-1.21.10.8
Social response proportion0.40.50.80.80.6-0.20.60.70.6-0.7-0.9
Social responses0.10.20.90.60.20.10.10.30.0-0.4-0.9
Social time2.83.75.3-1.9-2.10.4-2.3-2.3-2.31.81.5
Conditioned locomotion0.80.91.9-1.4-1.01.0-0.5-0.9-1.00.90.8
Cocaine response after cond. corrected0.20.21.0-0.6-0.31.00.10.1-0.20.30.4
Cocaine response after cond. not corrected0.40.42.2-0.7-0.51.50.20.1-0.30.40.6
Cocaine response before conditioning0.20.30.5-0.5-0.70.4-0.4-0.4-0.50.50.6
Saline control response0.10.20.8-0.3-0.10.90.20.2-0.10.20.8
Condit. Reinf. active minus inactive responses0.10.21.00.30.3-1.0-0.2-0.30.1-0.1-0.1
Condit. Reinf. active-inactive response ratio0.10.10.40.20.3-0.6-0.1-0.20.1-0.10.2
Condit. Reinf. active responses0.81.12.61.11.2-1.60.70.71.0-1.0-1.0
Condit. Reinf. inactive responses1.41.72.71.31.2-1.61.01.11.1-1.3-1.5
Condit. Reinf. lever presses0.30.41.11.00.6-0.60.30.50.4-0.6-1.0
Condit. Reinf. lever reinforcers received0.40.62.01.00.8-1.40.20.20.7-0.7-0.6
Pavlov. Cond. lever latency0.30.31.2-1.1-0.60.6-0.1-0.3-0.40.60.5
Pavlov. Cond. magazine entry latency0.50.61.8-0.0-0.5-0.2-1.3-1.1-0.90.60.3
Pavlov. Cond. change in total contacts0.60.82.51.40.9-1.6-0.10.20.7-0.9-0.5
Pavlov. Cond. index score0.10.20.60.60.0-0.5-0.8-0.5-0.2-0.0-0.0
Pavlov. Cond. latency score0.20.20.60.60.0-0.5-0.8-0.5-0.2-0.0-0.1
Pavlov. Cond. lever contacts0.40.51.41.20.6-0.80.10.30.5-0.7-0.7
Pavlov. Cond. magazine entry number0.20.20.7-0.7-0.10.50.80.50.20.0-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.40.30.8-1.21.00.70.9-0.6-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.70.1-0.3-0.7-0.4-0.2-0.0-0.1
Pavlov. Cond. response bias0.20.30.80.80.3-0.9-0.4-0.10.1-0.3-0.3
Conditioned reinforcement - actives0.70.72.0-0.5-0.4-0.3-1.0-0.9-0.60.81.4
Conditioned reinforcement - inactives0.00.10.30.10.1-0.5-0.10.00.1-0.00.3
Conditioned locomotion1.41.72.91.41.7-0.31.41.61.2-1.3-0.9
Intermittent access intake day 1-15 change0.70.71.5-0.6-0.70.7-0.8-0.8-0.80.81.2
Intermittent access intake escalation0.70.61.4-0.6-0.71.0-0.6-0.6-0.70.81.2
Intermittent access intake escalation 20.50.51.8-0.5-0.50.3-0.7-0.8-0.40.71.4
Intermitt. access day 1 inactive lever presses1.81.92.71.21.3-1.61.31.51.2-1.7-1.2
Intermitt. access day 15 inactive lever presses1.71.95.61.11.1-2.40.81.11.1-1.5-1.3
Intermitt. access escalation Index0.10.00.10.30.20.00.00.20.2-0.1-0.4
Intermittent access day 1 total infusions0.50.61.00.71.0-1.00.60.70.8-0.6-0.4
Intermittent access day 15 total infusions0.10.10.30.40.5-0.20.30.30.4-0.20.4
Intermittent access terminal intake (last 3 days)0.20.20.50.60.7-0.50.30.40.5-0.30.2
Intermittent access total infusions0.30.30.60.60.8-0.40.60.60.6-0.40.0
Intermittent access day 1 locomotion0.10.10.10.10.30.30.30.40.1-0.10.1
Intermittent access day 15 total locomotion0.40.51.20.50.70.51.01.10.5-0.5-0.0
Intermittent access total locomotion0.70.81.60.91.00.11.11.30.8-0.8-0.6
Intermittent access standard deviation0.60.71.01.01.0-0.80.80.81.0-0.6-0.3
Cocaine induced anxiety3.74.25.51.91.9-1.52.22.42.2-2.2-2.1
Post-drug Anxiety1.92.12.61.11.3-1.31.51.61.4-1.6-1.6
Baseline Anxiety3.13.34.9-1.8-1.71.1-2.0-2.2-2.01.91.4
Lifetime Intake0.50.61.00.81.0-0.60.80.80.9-0.6-0.1
Incentive Sensitization - Responses3.03.04.91.81.9-2.21.21.61.7-1.8-1.5
Incentive Sensitization - Breakpoint3.63.65.62.02.0-2.41.41.71.9-1.9-1.7
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.2-0.0-0.4-0.4-0.20.60.6
Progressive ratio test 1 breakpoint0.30.40.8-0.4-0.40.0-0.7-0.7-0.40.80.9
Progressive ratio test 1 inactive lever presses0.10.10.20.20.3-0.40.20.40.2-0.2-0.5
Progressive ratio test 2 active lever presses0.80.82.51.01.1-1.60.40.60.9-0.7-0.3
Progressive ratio test 2 breakpoint0.80.82.80.91.0-1.70.30.60.9-0.7-0.4
Progressive ratio test 2 inactive lever presses0.60.72.60.90.9-1.60.20.40.7-0.8-0.2
Total sessions with >9 infusions0.10.10.20.20.40.40.40.30.20.10.5
Short access day 1 total inactive lever presses3.03.34.61.72.1-1.71.82.12.0-1.9-1.1
Short access day 10 total inactive lever presses3.94.35.22.02.2-1.72.22.32.3-2.2-1.7
Short access day 1 total infusions1.11.21.81.21.2-1.01.01.11.3-1.1-0.1
Short access day 10 total infusions0.30.30.7-0.5-0.30.4-0.4-0.5-0.50.70.8
Short access total infusions0.50.60.90.80.9-0.60.80.81.0-0.6-0.0
Short access day 1 locomotion0.20.20.50.40.7-0.20.20.30.3-0.30.7
Short access day 10 total locomotion0.80.91.3-0.9-1.01.0-0.8-0.8-1.01.01.2
Short access total locomotion0.10.10.4-0.2-0.10.4-0.1-0.1-0.20.30.7
Compulsive drug intake0.20.21.20.20.3-1.1-0.3-0.30.1-0.3-0.5
One hour access (0.3 mA shock)0.00.00.20.30.40.00.10.20.2-0.00.2
One hour access (shock baseline)0.30.31.5-0.2-0.11.20.10.1-0.20.50.9
Number of responses in last shaping day0.80.82.6-0.5-0.6-0.2-1.2-1.0-0.80.61.6
Context. condit. distance diff. score3.54.26.11.72.1-1.32.52.42.2-2.0-2.0
Locomotion velocity, session 12.42.53.51.91.7-1.21.41.51.6-1.8-1.5
Locomotion distance, session 10.00.10.1-0.0-0.1-0.3-0.3-0.3-0.10.00.3
Locomotion velocity, session 23.94.56.52.32.2-0.22.32.52.1-2.2-2.3
Locomotion distance, session 20.10.10.40.3-0.1-0.6-0.6-0.4-0.10.1-0.2
Locomotion velocity, session 32.02.43.71.51.6-0.01.81.91.4-1.6-1.5
Locomotion distance, session 30.30.31.9-0.3-0.41.4-0.1-0.1-0.50.40.2
Stereotopy head waving bouts, day 32.93.54.62.12.0-1.31.62.01.8-2.1-1.8
Stereotopy head waving duration, day 35.16.28.32.42.7-1.52.62.92.6-2.7-2.4
Locomotion velocity, session 70.40.41.20.40.40.40.70.90.4-0.5-1.1
Locomotion distance, session 70.10.10.2-0.1-0.40.3-0.5-0.3-0.40.4-0.0
Stereotopy head waving bouts, day 75.56.29.02.32.6-0.62.93.02.6-2.5-2.5
Stereotopy head waving duration, day 72.42.94.71.41.70.12.22.21.8-1.7-1.8
Locomotion velocity, session 810.212.214.73.73.7-2.33.53.83.8-3.5-3.4
Locomotion distance, session 82.03.03.61.81.8-0.91.81.91.9-1.7-1.9
Degree of sensitization distance1.11.13.50.90.9-1.90.60.71.0-0.9-1.0
Degree of sensitization stereotypy2.52.74.71.31.7-0.02.22.01.8-1.6-1.6
Condit. Reinf. active minus inactive responses2.22.43.3-1.8-1.80.5-1.7-1.6-1.81.61.1
Condit. Reinf. active-inactive response ratio1.41.53.3-1.8-1.40.3-1.0-1.1-1.41.21.1
Condit. Reinf. active responses2.73.24.4-1.8-2.01.2-2.0-1.8-2.11.81.3
Condit. Reinf. inactive responses0.60.71.4-0.3-0.90.9-1.2-1.0-0.90.90.5
Incentive salience index mean2.32.83.9-1.7-1.90.8-1.9-1.8-2.01.71.2
Condit. Reinf. lever presses0.91.21.9-0.8-1.20.8-1.4-1.2-1.31.10.6
Time in familiar zone, hab. session 11.00.91.21.01.1-0.50.91.10.9-1.0-1.0
Time in novel zone, hab. session 10.40.41.1-1.1-0.60.5-0.1-0.3-0.40.50.9
Total zone transitions, hab. session 11.52.13.1-1.2-1.40.6-1.7-1.8-1.51.41.6
Total locomotion distance, hab. session 10.10.10.50.70.30.50.10.30.2-0.3-0.1
Locomotion velocity, hab. session 10.20.20.80.90.40.40.10.40.3-0.4-0.4
Time in familiar zone, hab. session 20.10.10.50.1-0.10.70.10.2-0.1-0.0-0.1
Time in novel zone, hab. session 20.10.10.4-0.30.1-0.60.1-0.10.10.00.6
Total zone transitions, hab. session 20.70.91.71.20.9-1.30.40.60.9-0.9-0.8
Total locomotion distance, hab. session 20.40.51.11.10.7-0.30.50.70.7-0.7-0.8
Locomotion velocity, hab. session 20.30.41.01.00.6-0.30.20.40.5-0.6-0.7
Novel to familiar place preference ratio0.30.40.90.10.6-0.21.00.70.7-0.6-0.2
Novelty place preference0.60.61.60.30.9-0.21.21.01.0-0.8-0.4
Time in novel zone, NPP test0.80.82.10.30.9-0.21.41.11.1-0.9-0.4
Total zone transitions, NPP test0.10.10.20.1-0.2-0.5-0.5-0.3-0.10.10.2
Total locomotion distance, NPP test0.40.51.21.10.80.10.60.90.7-0.7-0.6
Locomotion velocity, NPP test0.10.20.60.80.30.50.00.30.2-0.2-0.4
Pavlov. Cond. lever latency1.51.93.00.91.3-0.91.71.61.4-1.4-1.3
Pavlov. Cond. magazine entry latency3.54.56.3-2.0-2.20.4-2.5-2.5-2.12.12.3
Pavlov. Cond. change in total contacts3.53.85.2-1.8-2.00.5-2.3-2.3-2.01.92.1
Pavlov. Cond. index score2.33.04.5-1.6-1.70.4-2.1-2.1-1.71.81.8
Pavlov. Cond. latency score1.62.03.1-1.2-1.40.4-1.8-1.8-1.41.51.5
Pavlov. Cond. lever contacts2.02.33.6-1.1-1.51.0-1.9-1.8-1.61.61.5
Pavlov. Cond. magazine entry number3.84.86.92.22.3-0.62.52.62.2-2.2-2.2
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.2-0.40.1-0.4-0.4-0.30.10.5
Pavlov. Cond. lever-magazine prob. diff.3.13.85.5-1.8-2.00.6-2.3-2.4-2.02.02.0
Pavlov. Cond. response bias4.35.37.2-2.1-2.40.9-2.7-2.7-2.42.42.3
Bone: apparent density0.30.51.7-0.5-0.70.3-0.8-0.8-0.50.51.3
Bone surface0.10.10.5-0.1-0.1-0.1-0.3-0.3-0.10.20.7
Bone volume0.10.10.7-0.1-0.2-0.0-0.3-0.2-0.10.10.8
Bone: connectivity density0.20.30.8-0.5-0.40.3-0.5-0.5-0.50.40.9
Bone: cortical apparent density0.81.12.2-0.7-1.0-0.4-1.5-1.3-1.10.90.9
Bone: cortical area0.30.41.00.20.6-0.21.00.80.7-0.7-0.4
Bone: cortical porosity0.10.10.2-0.00.10.10.40.30.3-0.2-0.5
Bone: cortical porosity0.30.30.70.20.40.00.80.70.6-0.5-0.8
Bone: cortical thickness0.30.50.7-0.7-0.6-0.7-0.8-0.9-0.70.40.6
Bone: cortical thickness0.10.10.9-0.3-0.2-0.9-0.0-0.1-0.1-0.20.1
Bone: cortical tissue density0.60.81.8-0.5-0.8-0.5-1.3-1.2-0.90.80.7
Bone: elastic displacement1.31.52.51.11.2-0.21.51.61.3-1.2-1.1
Bone: elastic work5.26.79.82.52.7-1.03.03.12.7-2.6-2.6
Bone: endosteal estimation3.37.111.02.52.7-0.33.33.32.9-2.6-2.5
Bone: endosteal perimeter2.14.47.91.62.01.02.82.82.2-1.9-1.8
Bone: final force0.71.13.10.81.0-1.80.80.81.0-1.1-0.9
Bone: final moment1.11.84.11.01.3-2.01.11.21.3-1.4-1.2
Bone: marrow area3.47.311.42.52.8-0.43.33.43.0-2.7-2.5
Bone: maximum diameter3.97.111.42.22.6-0.73.43.32.9-2.7-2.5
Bone: maximum force1.52.73.61.21.6-1.91.71.61.7-1.7-1.6
Bone: maximum moment2.13.74.61.41.9-2.12.01.92.0-2.0-1.9
Bone: minimum diameter0.71.32.40.91.11.01.61.51.2-1.0-0.6
Bone: periosteal estimation2.24.57.51.72.1-0.32.72.72.3-2.1-1.9
Bone: periosteal perimeter1.52.65.71.01.50.72.42.21.6-1.4-1.4
Bone: post-yield work0.30.42.5-0.4-0.0-1.6-0.1-0.10.2-0.10.1
Bone: stiffness0.20.21.1-0.8-0.2-1.10.0-0.3-0.00.10.3
Bone: tissue strength0.30.30.50.20.5-0.60.40.50.5-0.5-0.7
Bone: trabecular number0.81.32.8-1.3-1.11.1-0.7-0.9-0.91.01.7
Bone: trabecular spacing1.92.44.41.71.4-1.21.41.51.5-1.5-2.1
Bone: trabecular thickness0.10.10.50.1-0.10.3-0.5-0.3-0.30.20.7
Bone: trabecular tissue density0.20.30.8-0.2-0.4-0.6-0.9-0.8-0.40.40.5
Breakpoint value in progressive ratio session0.30.30.60.60.5-0.10.50.70.4-0.5-0.8
Distance traveled before self-admin0.10.10.30.1-0.0-0.5-0.3-0.4-0.00.1-0.5
Distance traveled after self-admin0.91.01.41.11.1-1.00.70.91.0-1.0-1.2
Delta time in closed arm before/after self-admin0.30.31.80.20.1-1.3-0.3-0.20.2-0.20.1
Delta time in open arm before/after self-admin1.01.02.20.60.61.11.41.50.7-0.8-0.8
Diff in mean of infusions in LGA sessions1.31.52.9-0.7-0.9-1.4-1.7-1.7-0.90.91.2
Extinction: sum of active levers before priming0.10.10.3-0.2-0.2-0.3-0.10.1-0.20.0-0.6
Active lever presses in extinction session 60.30.31.00.10.4-0.70.50.50.3-0.5-1.0
Delta distance traveled before/after self-admin2.02.23.71.31.6-0.71.71.91.5-1.7-1.0
Delta ambulatory time before/after self-admin1.51.62.61.11.4-0.71.51.61.4-1.3-0.7
Time in closed arm before self-admin1.92.12.5-1.3-1.61.3-1.5-1.5-1.51.51.5
Time in closed arm after self-admin0.30.41.6-0.4-0.30.3-0.6-0.4-0.40.51.3
Time in open arm before self-admin0.20.20.2-0.4-0.40.5-0.3-0.5-0.40.4-0.4
Time in open arm after self-admin1.11.33.70.80.61.01.31.30.7-0.8-1.9
Sum of active levers in priming session hrs 5-60.40.40.70.70.6-0.30.60.60.6-0.6-0.9
Time to tail flick, vehicle, before self-admin0.10.10.20.30.2-0.40.20.40.3-0.4-0.2
Time to tail flick, vehicle, after self-admin0.20.20.8-0.6-0.40.9-0.20.0-0.60.40.2
Time to tail flick, test, before self-admin0.10.10.10.0-0.20.30.20.40.0-0.1-0.3
Time to tail flick, test, after self-admin1.51.62.1-1.0-1.31.0-1.4-1.3-1.21.31.4
Delta time to tail flick, vehicle, before/after SA0.20.20.40.40.6-0.70.30.30.5-0.4-0.5
Delta time to tail flick, test, before/after SA1.00.91.6-0.6-0.70.4-1.2-1.2-0.80.91.3
Ambulatory time before self-admin0.20.20.70.2-0.0-0.9-0.1-0.10.1-0.2-0.6
Ambulatory time after self-admin0.40.40.80.70.7-0.90.40.50.6-0.7-0.6
Total heroin consumption0.40.51.10.60.5-1.00.70.50.7-0.7-1.0
Area under the delay curve2.12.33.4-1.6-1.60.2-1.8-1.8-1.71.61.0
Delay disc. indifference point, 0s delay0.10.10.3-0.10.10.20.60.60.1-0.4-0.6
Delay disc. indifference point, 16s delay2.42.43.8-1.3-1.50.6-2.0-2.0-1.71.81.1
Delay disc. indifference point, 2s delay0.70.71.1-1.1-1.0-0.1-1.0-0.9-1.00.80.5
Delay disc. indifference point, 24s delay0.60.51.0-0.5-0.8-0.2-0.9-1.0-0.81.0-0.2
Delay disc. indifference point, 4s delay0.30.30.9-0.5-0.3-1.0-0.6-0.6-0.40.20.4
Delay disc. indifference point, 8s delay2.93.04.2-1.7-1.80.9-2.0-2.1-2.01.91.0
Delay discount exponential model param2.12.23.41.51.6-0.11.81.81.7-1.6-0.9
Delay discount hyperbolic model param1.51.62.41.41.3-0.01.51.61.5-1.3-0.8
Fecal boli incidents, locomotor time 10.10.10.30.40.1-0.30.10.20.1-0.2-0.5
Change in fecal boli incidents, locomotor task0.20.20.9-0.4-0.21.00.30.2-0.10.10.4
Time >=10cm from walls, locomotor time 10.30.30.50.70.6-0.10.50.60.6-0.6-0.4
Bouts of movement, locomotor time 10.00.10.10.0-0.0-0.3-0.4-0.3-0.20.3-0.1
Total resting periods, locomotor time 10.10.10.4-0.1-0.2-0.4-0.6-0.5-0.30.50.1
Rest time, locomotor task time 10.30.31.00.70.6-0.20.40.50.4-0.2-1.0
Distance moved, locomotor task time 10.10.10.20.20.1-0.20.10.20.3-0.30.5
Vertical activity count, locomotor time 10.10.20.9-0.2-0.1-0.3-0.2-0.4-0.00.00.9
Time >=10cm from walls, locomotor time 20.10.20.7-0.1-0.30.8-0.2-0.0-0.20.20.6
Bouts of movement, locomotor time 20.80.91.9-1.4-1.2-0.0-0.9-0.8-1.30.70.5
Total resting periods, locomotor time 20.91.01.8-1.4-1.3-0.2-1.0-1.0-1.30.80.5
Rest time, locomotor task time 20.20.30.5-0.4-0.60.1-0.6-0.6-0.60.70.6
Distance moved, locomotor task time 21.01.22.00.91.1-0.01.31.41.1-1.2-1.0
Vertical activity count, locomotor time 21.21.32.01.11.1-0.11.41.41.2-1.3-0.9
Weight adjusted by age0.50.61.00.80.90.10.91.00.8-0.6-0.7
Seeking ratio, delayed vs. immediate footshock1.92.22.8-1.2-1.61.6-1.4-1.4-1.41.51.7
Locomotion in novel chamber0.60.85.2-0.2-0.12.30.00.0-0.20.60.6
Locomotion in novel chamber post-restriction0.70.91.4-0.8-1.11.2-0.8-0.9-1.00.90.8
Progressive ratio0.40.51.0-0.6-0.4-0.4-0.9-1.0-0.60.90.5
Food seeking constrained by brief footshock0.70.81.31.11.0-0.70.80.81.1-1.0-0.4
Seeking ratio, punishment vs. effort0.80.91.61.10.9-0.31.01.11.0-1.3-0.7
Run reversals in cocaine runway, females1.81.85.1-0.8-0.82.3-1.1-1.1-1.21.21.5
Run reversals in cocaine runway, males0.30.20.8-0.10.20.00.90.80.3-0.6-0.2
Latency to leave start box in cocaine runway1.71.82.51.61.3-0.91.41.51.5-1.3-1.3
Latency to leave start box in cocaine runway, F0.40.50.80.90.7-0.70.60.70.8-0.7-0.3
Latency to leave start box in cocaine runway, M2.01.92.51.41.5-1.01.41.51.5-1.3-1.6
Cd content in liver0.30.31.4-1.2-0.5-0.20.0-0.3-0.20.50.5
Co content in liver1.01.21.71.21.2-0.51.11.31.1-1.3-0.5
Cu content in liver5.36.47.6-2.1-2.52.6-2.5-2.6-2.52.62.8
Fe content in liver0.20.30.50.50.6-0.10.50.70.7-0.60.5
K content in liver0.50.51.31.10.7-1.1-0.00.30.5-0.8-0.6
Mg content in liver0.20.20.50.70.3-0.7-0.5-0.20.0-0.3-0.2
Mn content in liver0.70.81.31.11.0-0.40.81.10.7-1.1-0.8
Na content in liver3.84.05.4-2.2-2.10.7-2.1-2.3-2.12.11.9
Rb content in liver0.30.40.6-0.8-0.5-0.1-0.6-0.7-0.70.50.8
Se content in liver0.10.10.30.5-0.20.2-0.5-0.4-0.10.10.5
Sr content in liver0.60.50.6-0.7-0.80.7-0.8-0.7-0.70.80.7
Zn content in liver1.01.01.8-0.9-1.01.1-1.0-1.0-0.90.91.3