Hub : Genes

Slc15a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000021644	0.17	0.07	5.1e-12	0.09	0.08	0.08	0.08	6.1e-10	5.0e-09	6.0e-09	1.2e-09
2	Adipose	mRNA stability	ENSRNOG00000021644	0.03	0.02	1.3e-03	0.01	0.01	0.01	0.01	4.4e-02	1.8e-02	6.0e-02	2.6e-02
3	BLA	mRNA stability	ENSRNOG00000021644	0.08	0.05	3.0e-03	0.06	0.03	0.03	0.05	6.0e-04	8.7e-03	9.7e-03	1.2e-03
4	Brain	mRNA stability	ENSRNOG00000021644	0.13	0.07	5.0e-07	0.02	0.05	0.06	0.06	2.7e-03	1.8e-05	2.7e-06	5.4e-06
5	Liver	gene expression	ENSRNOG00000021644	0.05	0.03	6.9e-05	0.01	0.01	0.01	0	1.5e-02	1.6e-02	4.3e-02	7.8e-02
6	NAcc	mRNA stability	ENSRNOG00000021644	0.03	0.02	6.1e-03	0.02	0.02	0.01	0.01	8.4e-03	1.5e-02	3.8e-02	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	1.9	6.3	16.2	-0.7	4.0	0.8	-1.7	2.9	3.0
BMI without tail	0.7	1.4	4.1	0.0	2.0	0.4	-0.1	1.3	1.6
Body weight	1.6	6.9	17.7	-0.3	4.2	0.2	-1.7	3.1	3.3
Epididymis fat weight	1.1	2.6	6.7	-2.6	0.4	1.4	-2.2	-1.0	-0.9
Glucose	1.5	2.3	3.4	-1.8	-1.0	1.5	-0.9	-1.8	-1.8
Heart weight	0.7	0.9	2.4	-1.5	0.1	1.3	-0.7	-0.9	-0.6
Left kidney weight	0.9	2.7	6.0	-2.1	1.2	2.4	-2.1	-0.2	-0.2
Right kidney weight	0.4	1.2	2.6	-1.3	1.0	1.4	-1.6	0.2	0.2
Tail length	0.2	0.5	0.8	0.8	0.8	-0.7	0.3	0.8	0.9
Length with tail	0.7	2.7	6.7	-0.2	2.6	0.0	-1.4	1.9	1.9
Length without tail	0.8	1.7	3.5	-0.4	1.9	-0.1	-1.5	1.6	1.3
Liver weight, left	0.6	1.0	1.9	-0.4	-1.4	0.7	0.2	-1.2	-1.4
Liver weight, right	0.1	0.2	0.5	0.1	-0.7	-0.1	-0.7	-0.2	-0.2
Parametrial fat weight	2.4	4.7	10.8	-3.3	0.2	2.9	-2.2	-1.4	-1.6
Retroperitoneal fat weight	2.8	9.3	20.4	-4.5	-0.8	3.3	-2.4	-3.0	-3.1
Intraocular pressure	0.2	0.3	1.1	0.7	-0.2	-0.4	1.0	0.3	0.4
Extensor digitorum longus weight	3.1	12.3	23.5	1.3	4.8	-1.1	-1.4	4.8	4.9
Soleus weight	1.3	3.7	7.5	-1.0	-2.6	0.7	0.1	-2.5	-2.7
Tibialis anterior weight	4.6	16.0	30.0	3.2	4.3	-2.8	0.2	5.4	5.5
Tibia length	0.5	1.3	3.4	0.1	1.9	-0.4	-0.6	1.4	1.3
Number of licking bursts	0.2	0.2	0.4	-0.7	0.6	0.3	-0.6	0.1	-0.1
Food consumed during 24 hour testing period	0.4	0.5	1.2	0.4	-1.1	-0.4	0.7	-0.7	-0.7
Times rat made contact with spout	0.6	0.7	1.6	1.2	-0.4	-1.3	0.7	0.7	0.3
Mean time between licks in bursts	0.5	0.7	1.5	0.9	0.4	-0.3	-0.4	1.2	1.2
Mean num. licks in bursts	0.8	1.0	2.2	1.5	-1.1	-1.2	1.2	0.1	0.1
Std. dev. time between licks in bursts	0.3	0.4	0.6	-0.5	-0.8	0.6	-0.3	-0.7	-0.6
Water consumed over 24 hours	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.2	0.1	0.1
Indifference point 0 sec	0.1	0.2	0.3	0.2	0.5	-0.3	-0.5	0.5	0.5
Indifference point AUC	1.0	1.2	2.0	1.2	0.6	-1.1	-0.4	1.3	1.4
Indifference point function ln k	1.3	1.9	3.8	-1.9	-0.4	1.6	-0.4	-1.6	-1.4
Indifference point function log k	1.3	1.9	3.8	-1.9	-0.4	1.6	-0.4	-1.6	-1.4
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.3	0.3	-0.4	-0.3	0.4	0.4
Delay discounting total patch changes 12 sec	2.5	3.4	6.1	1.8	1.7	-1.6	-0.3	2.3	2.5
Delay discounting total patch changes 18 sec	0.5	0.6	1.4	1.2	0.0	-1.2	0.2	0.8	0.6
Delay discounting total patch changes 24 sec	3.2	4.0	7.2	0.7	2.7	-0.5	-1.7	2.5	2.6
Delay discounting total patch changes 6 sec	0.3	0.4	0.9	-0.2	0.9	0.2	-1.0	0.6	0.6
Delay discounting time to switch 0 sec	0.4	0.7	1.8	-0.4	1.3	0.6	-0.6	0.8	0.7
Delay discounting water rate 0 sec	0.7	1.1	2.8	-0.1	-1.7	-0.3	0.5	-1.4	-1.3
Delay discounting water rate 12 sec	0.7	1.1	2.3	-0.9	-1.2	0.3	0.2	-1.2	-1.5
Delay discounting water rate 18 sec	1.1	1.4	2.8	-1.3	-0.8	1.1	-0.3	-1.7	-1.5
Delay discounting water rate 24 sec	0.8	1.0	2.2	-0.7	-1.0	0.4	0.8	-1.3	-1.5
Delay discounting water rate 6 sec	0.7	1.1	2.2	-0.9	-1.2	0.3	0.2	-1.3	-1.5
Locomotor activity	0.5	0.8	2.0	-0.0	-1.4	-0.4	0.1	-1.1	-1.3
Locomotor testing distance	0.5	0.8	1.8	0.0	-1.4	-0.3	-0.1	-1.1	-1.2
Locomotor testing rearing	0.5	0.8	1.9	0.7	-1.4	-0.9	0.4	-0.7	-0.9
Light reinforcement 1	0.2	0.4	1.0	0.8	-1.0	-0.5	0.6	-0.5	-0.4
Light reinforcement 2	0.9	1.1	2.4	-1.3	-0.0	1.6	-1.2	-0.8	-0.8
Reaction time number correct	1.0	1.4	4.4	1.1	0.5	-1.4	2.1	0.7	0.3
Reaction time mean minus median	0.9	1.2	2.2	1.5	0.3	-1.5	1.3	0.7	0.8
Reaction time mean minus median AUC	1.9	2.4	4.8	2.1	-0.3	-2.2	2.2	0.5	0.7
Reaction time num false alarms	0.2	0.2	0.8	-0.1	-0.9	-0.1	0.1	-0.5	-0.7
Reaction time num false alarms AUC	0.1	0.2	0.6	0.2	-0.8	-0.3	0.3	-0.3	-0.4
Reaction time trials correct on left	1.0	1.4	4.4	1.1	0.5	-1.4	2.1	0.7	0.3
Reaction time trials on left	1.1	1.6	4.9	1.2	0.4	-1.5	2.2	0.7	0.4
Reaction time mean	0.7	1.0	2.1	1.4	-0.5	-1.2	1.2	0.4	0.5
Reaction time mean AUC	0.6	0.8	1.7	1.3	-0.6	-1.1	1.2	0.2	0.3
Median of all reaction times	0.3	0.4	1.0	1.0	-0.1	-0.7	0.6	0.6	0.6
Reaction time omissions	0.5	0.7	1.6	0.9	-0.4	-1.3	1.2	0.2	0.0
Reaction time false alarm rate	0.5	0.6	1.3	-0.7	-0.9	0.7	-1.1	-0.7	-0.6
Reaction time premature initiation rate	1.5	2.0	4.4	-0.9	2.1	1.0	-1.7	1.1	1.3
Reaction time premature initiations	1.0	1.5	4.2	0.2	2.0	-0.3	-0.1	1.5	1.5
Std. dev. reaction times	1.1	1.6	3.2	1.6	-0.8	-1.8	1.8	0.1	0.2
Reaction time trials completed	1.1	1.6	4.9	1.2	0.4	-1.5	2.2	0.7	0.4
Reaction time trials AUC	1.0	1.4	4.5	1.1	0.4	-1.4	2.1	0.6	0.3
Social response proportion	0.3	0.3	0.6	-0.6	-0.3	0.6	0.3	-0.7	-0.8
Social responses	0.4	0.6	1.1	0.3	-1.1	-0.4	0.9	-0.6	-0.8
Social time	0.8	1.1	2.5	1.4	-0.7	-1.2	1.6	0.1	-0.1
Conditioned locomotion	0.3	0.4	0.8	0.3	0.7	0.2	-0.5	0.9	0.8
Cocaine response after cond. corrected	0.1	0.1	0.1	0.4	0.2	-0.1	0.2	0.3	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.4	0.6	-0.2	-0.2	0.2	0.3	0.3
Cocaine response before conditioning	0.3	0.3	0.7	0.8	-0.6	-0.8	0.4	0.2	0.0
Saline control response	1.2	1.7	2.7	1.4	1.0	-1.3	0.7	1.6	1.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.8	0.9	-0.6	-0.7	0.4	0.4	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	-0.3	1.0	0.4	-0.3	0.6	0.6
Condit. Reinf. active responses	0.2	0.3	0.7	0.9	-0.6	-0.8	0.3	0.4	0.3
Condit. Reinf. inactive responses	0.7	0.8	2.4	0.8	-1.6	-0.9	0.7	-0.6	-0.6
Condit. Reinf. lever presses	0.6	0.9	2.1	0.4	1.1	-0.6	-0.2	1.4	1.1
Condit. Reinf. lever reinforcers received	0.5	0.7	1.4	1.2	-0.2	-1.1	0.6	0.9	0.7
Pavlov. Cond. lever latency	0.8	1.0	2.2	-0.2	-1.2	0.2	0.9	-1.5	-1.3
Pavlov. Cond. magazine entry latency	4.1	4.7	9.2	1.9	2.1	-1.5	0.1	3.0	2.9
Pavlov. Cond. change in total contacts	1.5	2.1	4.1	1.3	1.2	-1.3	0.0	2.0	1.9
Pavlov. Cond. index score	2.8	3.6	7.6	1.2	2.2	-1.2	-0.3	2.8	2.5
Pavlov. Cond. latency score	2.6	3.2	6.9	1.0	2.2	-1.0	-0.4	2.6	2.4
Pavlov. Cond. lever contacts	1.2	1.7	3.5	1.3	0.9	-1.4	0.2	1.9	1.5
Pavlov. Cond. magazine entry number	6.1	7.5	14.9	-2.0	-3.1	1.7	-0.0	-3.9	-3.7
Pavlov. Cond. intertrial magazine entries	1.2	1.6	3.3	-0.5	-1.7	-0.0	0.7	-1.8	-1.7
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.0	8.3	1.4	2.2	-1.4	-0.2	2.9	2.6
Pavlov. Cond. response bias	2.0	2.8	5.7	1.5	1.5	-1.3	-0.1	2.4	2.2
Conditioned reinforcement - actives	0.7	0.7	1.8	0.4	-1.3	0.0	0.6	-0.9	-0.9
Conditioned reinforcement - inactives	0.4	0.5	1.0	-0.7	-0.3	0.8	-1.0	-0.6	-0.4
Conditioned locomotion	1.1	1.4	1.7	-1.3	-0.9	1.3	-1.2	-1.1	-1.1
Intermittent access intake day 1-15 change	1.2	1.2	3.3	0.7	-1.8	-0.7	1.0	-1.0	-1.0
Intermittent access intake escalation	0.8	0.8	2.1	0.8	-1.5	-0.8	0.8	-0.6	-0.6
Intermittent access intake escalation 2	0.6	0.6	1.6	1.1	-0.7	-1.3	0.7	-0.0	-0.0
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.9	-1.7	0.2	1.6	-1.2	-0.7	-0.6
Intermitt. access day 15 inactive lever presses	1.5	1.6	5.0	-1.5	1.1	1.0	-2.2	0.2	0.4
Intermitt. access escalation Index	2.1	1.9	4.1	-1.7	-0.3	2.0	-1.7	-0.7	-0.7
Intermittent access day 1 total infusions	3.0	3.4	6.8	-2.6	0.9	2.6	-2.5	-0.3	-0.2
Intermittent access day 15 total infusions	1.8	2.1	2.8	-1.6	-1.3	1.7	-1.2	-1.5	-1.4
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.9	-1.0	-0.1	1.0	-1.4	-0.3	-0.2
Intermittent access total infusions	1.4	1.5	3.1	-1.6	-0.1	1.7	-1.8	-0.5	-0.4
Intermittent access day 1 locomotion	3.6	3.7	7.3	-2.4	1.3	2.7	-2.7	0.1	0.2
Intermittent access day 15 total locomotion	1.0	1.1	3.0	-1.0	1.0	0.9	-1.7	0.3	0.6
Intermittent access total locomotion	3.1	3.5	8.6	-2.3	1.3	2.3	-2.9	0.3	0.5
Intermittent access standard deviation	1.3	1.4	2.7	1.6	-1.1	-1.7	1.5	-0.2	-0.1
Cocaine induced anxiety	0.5	0.6	1.7	0.8	0.5	-1.3	0.3	0.7	0.8
Post-drug Anxiety	1.1	1.2	2.2	1.2	0.9	-1.5	0.8	1.1	1.1
Baseline Anxiety	0.7	0.8	1.1	0.9	1.0	-0.7	0.4	1.0	1.0
Lifetime Intake	1.2	1.3	2.7	-1.5	0.1	1.6	-1.6	-0.4	-0.3
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.5	0.2	0.2	-0.7	0.1	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	-0.8	0.3	0.4	-0.9	-0.0	0.0
Progressive ratio test 1 active lever presses	1.0	1.0	1.6	-0.9	-1.0	1.2	-0.6	-1.1	-1.1
Progressive ratio test 1 breakpoint	0.9	0.9	1.4	-0.7	-1.1	1.1	-0.2	-1.2	-1.1
Progressive ratio test 1 inactive lever presses	0.9	0.9	2.3	-0.8	1.2	0.3	-1.5	0.7	0.8
Progressive ratio test 2 active lever presses	0.9	0.9	1.3	-1.1	-0.8	1.1	-0.8	-1.0	-0.9
Progressive ratio test 2 breakpoint	1.3	1.5	2.2	-1.3	-1.2	1.2	-0.6	-1.5	-1.3
Progressive ratio test 2 inactive lever presses	0.9	1.0	3.0	-1.3	0.2	0.9	-1.7	-0.4	-0.1
Total sessions with >9 infusions	1.1	1.3	2.8	-1.6	0.1	1.7	-1.3	-0.5	-0.5
Short access day 1 total inactive lever presses	1.1	1.2	2.4	-1.5	-0.1	1.6	-1.3	-0.7	-0.7
Short access day 10 total inactive lever presses	1.1	1.3	2.1	-1.1	-0.8	1.5	-0.5	-1.4	-1.2
Short access day 1 total infusions	0.3	0.4	0.8	-0.9	-0.1	0.8	-0.7	-0.4	-0.3
Short access day 10 total infusions	3.0	3.3	7.2	-2.2	1.1	2.7	-2.5	-0.1	0.2
Short access total infusions	1.0	1.1	2.3	-1.4	0.6	1.5	-1.5	-0.1	0.1
Short access day 1 locomotion	1.0	1.1	2.6	-0.8	1.0	1.1	-1.6	0.7	0.7
Short access day 10 total locomotion	1.8	2.0	4.6	-1.5	1.5	1.4	-2.2	0.6	0.7
Short access total locomotion	2.4	2.5	5.9	-1.3	1.7	1.6	-2.4	1.0	1.1
Compulsive drug intake	1.4	1.4	3.4	1.6	0.0	-1.8	1.2	0.7	0.7
One hour access (0.3 mA shock)	1.9	2.3	3.2	-1.8	-1.2	1.7	-1.2	-1.6	-1.5
One hour access (shock baseline)	2.6	3.0	4.2	-1.7	-1.6	1.9	-0.9	-2.1	-1.9
Number of responses in last shaping day	0.0	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.3	-0.4	0.5	0.5	-0.4	0.1	0.0
Locomotion velocity, session 1	0.4	0.5	1.3	1.1	-0.3	-0.8	0.5	0.5	0.6
Locomotion distance, session 1	0.8	1.0	1.9	1.1	0.7	-0.7	-0.6	1.3	1.4
Locomotion velocity, session 2	1.5	1.8	3.9	0.6	1.6	-0.3	-1.0	1.7	2.0
Locomotion distance, session 2	0.7	1.0	1.8	1.0	0.7	-0.7	-0.6	1.4	1.3
Locomotion velocity, session 3	2.1	2.5	6.7	-1.3	1.7	1.5	-2.6	0.9	0.7
Locomotion distance, session 3	0.4	0.4	1.0	-0.8	-0.1	1.0	-0.6	-0.4	-0.6
Stereotopy head waving bouts, day 3	0.9	1.1	3.9	-1.0	0.7	1.0	-2.0	0.0	0.2
Stereotopy head waving duration, day 3	0.6	0.8	2.0	-1.0	0.9	0.9	-1.4	0.1	0.3
Locomotion velocity, session 7	0.8	0.9	1.9	-1.1	0.4	1.4	-1.3	-0.3	-0.4
Locomotion distance, session 7	0.5	0.7	1.3	-1.1	0.2	1.1	-1.0	-0.5	-0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.2	0.7	-0.0	-0.1	0.7	0.6
Stereotopy head waving duration, day 7	0.6	0.8	1.7	0.4	1.2	-0.2	-0.1	1.3	1.1
Locomotion velocity, session 8	0.2	0.2	0.8	0.1	-0.2	-0.1	0.9	-0.5	-0.3
Locomotion distance, session 8	0.3	0.4	1.2	-0.4	0.7	0.6	-1.1	0.5	0.3
Degree of sensitization distance	0.6	0.6	1.4	-0.4	1.1	0.3	-1.2	0.5	0.8
Degree of sensitization stereotypy	0.7	0.8	1.6	0.7	1.0	-0.6	0.4	1.3	1.1
Condit. Reinf. active minus inactive responses	1.8	2.0	3.2	1.8	0.3	-1.7	0.6	1.6	1.6
Condit. Reinf. active-inactive response ratio	2.7	2.9	5.6	2.4	-0.3	-2.3	1.5	1.4	1.4
Condit. Reinf. active responses	1.3	1.6	2.9	1.2	0.7	-1.2	-0.5	1.6	1.7
Condit. Reinf. inactive responses	0.6	0.7	2.8	-0.7	0.7	0.6	-1.7	0.3	0.3
Incentive salience index mean	0.8	0.9	1.7	1.0	0.4	-0.9	-0.5	1.3	1.3
Condit. Reinf. lever presses	0.4	0.5	2.0	-0.5	0.3	0.6	-1.4	0.2	0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.2	0.2	-0.3	-0.5	0.3	0.3
Time in novel zone, hab. session 1	0.8	0.8	1.3	-0.2	-1.1	0.2	1.1	-1.1	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.8	0.9	0.0	-0.7	0.3	0.6	0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.6	-0.1	0.7	0.2	-0.8	0.5	0.5
Locomotion velocity, hab. session 1	0.3	0.5	1.0	0.4	0.8	-0.3	-0.6	0.9	1.0
Time in familiar zone, hab. session 2	0.9	0.9	2.1	0.4	-1.1	-0.4	1.4	-1.0	-0.9
Time in novel zone, hab. session 2	0.6	0.6	1.5	0.0	0.8	0.0	-1.2	1.0	0.8
Total zone transitions, hab. session 2	0.6	0.7	1.4	1.2	0.2	-0.9	-0.3	1.0	1.0
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.6	0.3	-0.3	-0.8	0.7	0.8
Locomotion velocity, hab. session 2	0.2	0.3	1.0	0.3	0.3	-0.0	-1.0	0.5	0.6
Novel to familiar place preference ratio	1.0	1.0	2.3	-0.5	1.5	0.7	-1.1	1.1	1.0
Novelty place preference	0.9	0.9	1.9	-0.7	1.4	0.9	-1.1	0.9	0.7
Time in novel zone, NPP test	1.1	1.1	2.8	-0.5	1.7	0.7	-1.0	1.2	1.0
Total zone transitions, NPP test	0.8	1.1	2.2	1.5	0.4	-1.1	0.2	1.3	1.3
Total locomotion distance, NPP test	0.1	0.2	0.3	0.5	-0.1	-0.2	-0.6	0.3	0.4
Locomotion velocity, NPP test	0.1	0.1	0.3	0.4	-0.5	-0.1	-0.5	-0.1	-0.0
Pavlov. Cond. lever latency	0.2	0.2	0.9	-0.2	-0.2	-0.0	1.0	-0.3	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.2	0.2	0.8	-0.2	-0.5	0.8	1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.5	-0.2	-0.5	-0.4	0.4	0.5
Pavlov. Cond. index score	0.1	0.2	0.4	0.5	0.0	-0.6	0.0	0.3	0.6
Pavlov. Cond. latency score	0.0	0.1	0.1	0.3	-0.1	-0.4	-0.1	0.0	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.0	-0.3	0.2	-0.6	-0.3	-0.1
Pavlov. Cond. magazine entry number	0.4	0.6	0.8	-0.9	-0.2	0.9	-0.7	-0.6	-0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.4	1.1	-1.0	-1.2	0.4	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.6	0.1	-0.7	-0.1	0.5	0.7
Pavlov. Cond. response bias	0.2	0.3	0.6	0.6	0.2	-0.4	-0.2	0.6	0.8
Bone: apparent density	0.2	0.3	1.2	-0.6	0.4	0.6	-1.1	0.2	-0.0
Bone surface	0.3	0.6	1.3	-0.6	1.1	0.6	-0.8	0.7	0.6
Bone volume	0.2	0.4	0.7	-0.7	0.7	0.6	-0.8	0.3	0.2
Bone: connectivity density	0.4	0.7	1.2	-0.1	1.1	0.4	-0.9	1.0	0.9
Bone: cortical apparent density	0.3	0.4	0.9	0.9	-0.0	-0.8	0.4	0.5	0.7
Bone: cortical area	0.1	0.1	0.3	0.1	0.1	-0.2	-0.5	0.3	0.3
Bone: cortical porosity	0.2	0.2	0.9	0.5	-0.1	-0.4	0.9	0.1	0.0
Bone: cortical porosity	0.4	0.4	1.2	0.8	0.1	-0.5	1.1	0.4	0.3
Bone: cortical thickness	1.2	2.0	4.0	2.0	0.1	-1.9	0.8	1.4	1.3
Bone: cortical thickness	0.2	0.2	0.4	0.7	-0.5	-0.4	0.6	0.2	0.1
Bone: cortical tissue density	0.4	0.5	1.0	1.0	0.1	-0.9	0.5	0.6	0.8
Bone: elastic displacement	1.0	1.1	2.3	0.9	-1.5	-0.9	1.3	-0.8	-0.7
Bone: elastic work	0.7	0.9	1.8	1.3	-0.1	-1.3	1.0	0.5	0.7
Bone: endosteal estimation	1.9	4.0	8.6	-2.9	0.3	2.5	-2.2	-1.5	-1.4
Bone: endosteal perimeter	2.4	4.8	10.8	-3.3	0.2	2.8	-2.2	-1.7	-1.6
Bone: final force	0.5	0.7	1.6	0.5	0.9	-0.5	-0.6	1.1	1.3
Bone: final moment	0.4	0.7	1.5	0.5	0.9	-0.5	-0.6	1.0	1.2
Bone: marrow area	2.0	4.3	9.3	-3.0	0.2	2.6	-2.2	-1.7	-1.6
Bone: maximum diameter	0.3	0.6	1.4	-1.0	0.6	0.9	-1.2	0.0	-0.0
Bone: maximum force	0.9	1.6	3.4	-0.5	1.8	0.5	-1.6	1.3	1.4
Bone: maximum moment	0.8	1.5	2.9	-0.4	1.7	0.4	-1.5	1.2	1.4
Bone: minimum diameter	1.7	3.2	7.5	-2.3	-0.0	2.1	-2.7	-1.0	-1.1
Bone: periosteal estimation	0.8	1.7	3.5	-1.8	0.4	1.5	-1.9	-0.6	-0.6
Bone: periosteal perimeter	0.1	0.2	0.6	-0.8	0.1	0.4	-0.7	-0.3	-0.3
Bone: post-yield work	2.5	3.4	6.8	-2.6	0.9	2.5	-2.3	-0.7	-0.8
Bone: stiffness	0.2	0.3	0.6	-0.5	0.8	0.4	-0.8	0.4	0.5
Bone: tissue strength	0.4	0.3	0.7	-0.2	-0.8	0.4	-0.0	-0.8	-0.7
Bone: trabecular number	0.5	0.7	1.9	-0.5	1.0	0.7	-1.4	0.7	0.5
Bone: trabecular spacing	1.1	1.5	2.7	1.6	-1.1	-1.5	1.6	-0.2	-0.1
Bone: trabecular thickness	0.4	0.5	0.8	-0.9	-0.3	0.4	-0.6	-0.7	-0.9
Bone: trabecular tissue density	1.5	2.2	4.5	-0.7	-1.9	0.2	0.5	-2.0	-2.1
Breakpoint value in progressive ratio session	2.5	2.8	5.0	2.1	0.9	-2.2	1.3	1.5	1.6
Distance traveled before self-admin	1.6	1.7	2.5	1.2	1.3	-1.5	0.5	1.6	1.4
Distance traveled after self-admin	0.2	0.2	0.5	0.5	0.3	-0.6	0.0	0.7	0.4
Delta time in closed arm before/after self-admin	2.0	1.9	3.7	0.6	1.7	-0.9	-0.5	1.9	1.8
Delta time in open arm before/after self-admin	0.9	0.8	1.5	1.2	0.6	-0.3	-0.1	1.2	1.2
Diff in mean of infusions in LGA sessions	2.0	2.2	3.9	2.0	0.8	-1.7	1.1	1.5	1.6
Extinction: sum of active levers before priming	1.1	1.1	2.3	0.6	1.5	-0.4	-0.0	1.3	1.4
Active lever presses in extinction session 6	1.6	1.5	2.8	1.7	0.5	-1.6	0.9	1.1	1.2
Delta distance traveled before/after self-admin	0.5	0.5	0.8	-0.5	-0.8	0.9	-0.2	-0.8	-0.9
Delta ambulatory time before/after self-admin	0.5	0.5	1.1	-0.3	-1.0	0.6	0.3	-0.9	-0.9
Time in closed arm before self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	-0.0	-0.1
Time in closed arm after self-admin	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1	0.0	-0.2
Time in open arm before self-admin	1.1	1.2	2.5	-0.8	-1.3	0.5	0.2	-1.6	-1.5
Time in open arm after self-admin	0.4	0.4	0.7	0.9	-0.8	-0.4	0.7	-0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.7	1.3	-0.0	-1.1	0.9	0.7	0.7
Time to tail flick, vehicle, before self-admin	1.1	1.2	2.5	-0.7	1.6	1.1	-1.0	1.1	0.8
Time to tail flick, vehicle, after self-admin	0.7	0.7	2.1	-0.1	1.4	0.2	-0.0	1.0	1.1
Time to tail flick, test, before self-admin	0.8	0.8	1.5	-1.2	1.0	0.7	-1.2	0.1	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.1	-0.8	-0.3	0.2	-0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.4	-0.1	-0.7	0.6	0.0	0.2
Delta time to tail flick, test, before/after SA	1.2	1.1	2.7	1.7	-1.0	-1.3	1.0	0.1	0.1
Ambulatory time before self-admin	1.4	1.4	2.6	1.3	0.9	-1.6	0.6	1.3	1.1
Ambulatory time after self-admin	0.2	0.2	0.4	-0.1	0.5	0.1	-0.6	0.5	0.3
Total heroin consumption	2.6	3.1	5.3	2.2	1.1	-2.3	1.6	1.5	1.7
Area under the delay curve	0.9	0.9	2.1	-1.3	0.4	1.4	-1.3	-0.2	-0.4
Delay disc. indifference point, 0s delay	1.0	1.0	2.0	-1.2	1.1	1.3	-1.4	0.2	0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.9	-0.6	0.4	0.8	-1.0	0.1	-0.0
Delay disc. indifference point, 2s delay	0.9	1.0	2.2	-1.5	0.2	1.3	-1.1	-0.6	-0.8
Delay disc. indifference point, 24s delay	0.4	0.4	1.1	-0.7	-0.1	0.9	-1.1	-0.2	-0.4
Delay disc. indifference point, 4s delay	1.3	1.3	2.6	-1.6	0.8	1.5	-1.6	0.0	-0.3
Delay disc. indifference point, 8s delay	1.1	1.1	2.4	-1.5	-0.0	1.6	-0.8	-0.9	-0.9
Delay discount exponential model param	1.0	1.0	2.3	1.3	-0.4	-1.5	1.3	0.2	0.5
Delay discount hyperbolic model param	1.1	1.1	2.4	1.4	-0.4	-1.5	1.4	0.2	0.5
Fecal boli incidents, locomotor time 1	1.0	1.1	1.9	1.4	0.2	-1.3	1.0	1.0	0.9
Change in fecal boli incidents, locomotor task	2.5	2.3	4.3	-2.1	-0.3	2.1	-1.0	-1.5	-1.5
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.6	-1.0	-0.0	1.3	-0.9	-0.5	-0.6
Bouts of movement, locomotor time 1	4.3	4.7	10.1	3.2	0.2	-2.8	1.8	2.0	1.9
Total resting periods, locomotor time 1	2.9	3.2	6.9	2.6	0.2	-2.2	1.5	1.7	1.6
Rest time, locomotor task time 1	0.1	0.1	0.4	0.1	-0.6	-0.0	0.3	-0.4	-0.1
Distance moved, locomotor task time 1	0.2	0.2	0.6	-0.8	0.4	0.4	-0.4	-0.3	-0.3
Vertical activity count, locomotor time 1	1.9	2.0	3.4	-1.4	-1.2	1.3	-0.1	-1.8	-1.8
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.3	-0.6	-0.1	0.6	-0.3	-0.4
Bouts of movement, locomotor time 2	5.1	5.5	8.5	2.8	1.6	-2.5	0.6	2.8	2.9
Total resting periods, locomotor time 2	4.7	5.0	7.8	2.7	1.4	-2.3	0.4	2.7	2.8
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.3	-0.6	0.4	-0.1	-0.3	-0.5
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.2	-0.4	-0.5	0.7	-0.6	-0.4
Vertical activity count, locomotor time 2	1.3	1.4	2.8	-0.2	-1.4	0.0	1.1	-1.7	-1.6
Weight adjusted by age	3.5	4.0	7.0	1.7	2.2	-1.7	0.1	2.5	2.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.5	-0.8	0.4	0.3	-1.2	0.2	0.4
Locomotion in novel chamber	0.9	1.1	2.1	-1.3	-0.8	0.5	0.0	-1.3	-1.4
Locomotion in novel chamber post-restriction	0.8	1.0	1.6	-0.2	-1.2	-0.0	1.0	-1.3	-1.3
Progressive ratio	0.2	0.3	0.8	-0.6	0.4	0.9	-0.6	-0.0	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.1	-0.5	0.4	0.0	-0.4	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.3	-0.5	-0.3	0.1	-0.2	-0.4
Run reversals in cocaine runway, females	1.0	1.0	1.9	-1.3	1.0	0.9	-1.4	0.2	0.3
Run reversals in cocaine runway, males	1.5	1.5	2.7	-0.6	-1.6	1.0	-0.3	-1.6	-1.5
Latency to leave start box in cocaine runway	1.6	1.8	3.9	-2.0	0.2	1.8	-1.4	-0.8	-0.9
Latency to leave start box in cocaine runway, F	0.3	0.4	0.8	-0.9	0.4	0.6	-0.9	0.1	-0.0
Latency to leave start box in cocaine runway, M	2.7	2.6	4.2	-1.6	-1.1	1.8	-0.1	-2.0	-2.1
Cd content in liver	1.0	1.1	2.4	0.2	-1.5	-0.4	1.1	-1.3	-1.1
Co content in liver	2.1	2.4	5.5	0.7	-2.3	-1.0	1.8	-1.5	-1.4
Cu content in liver	0.1	0.1	0.2	-0.2	0.4	0.2	-0.3	-0.2	0.3
Fe content in liver	0.1	0.1	0.2	-0.1	0.5	0.1	-0.1	0.5	0.4
K content in liver	1.2	1.2	3.9	-0.8	1.0	1.0	-2.0	0.5	0.6
Mg content in liver	0.8	0.8	3.4	-0.4	0.7	0.5	-1.8	0.3	0.5
Mn content in liver	0.7	0.8	1.4	-0.2	1.1	0.5	-1.2	1.0	1.1
Na content in liver	0.2	0.3	0.6	0.8	-0.1	-0.4	-0.2	0.6	0.6
Rb content in liver	0.7	0.9	1.8	-1.0	-0.8	0.5	-0.7	-1.4	-1.2
Se content in liver	0.8	1.0	1.7	-0.5	1.3	0.9	-1.3	0.9	0.9
Sr content in liver	4.5	4.1	7.5	1.9	1.8	-1.8	0.3	2.7	2.7
Zn content in liver	2.9	3.2	6.8	1.9	1.3	-1.3	-0.5	2.3	2.6