Celsr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability ENSRNOG00000021285 0.12 0.06 1.2e-14 0.11 0.1 0.1 0.1 4.5e-12 3.6e-11 4.0e-11 2.1e-11
2 BLA gene expression ENSRNOG00000021285 0.13 0.09 2.0e-03 0.04 0.03 0.01 0.03 4.0e-03 8.8e-03 6.6e-02 1.2e-02
3 BLA mRNA stability ENSRNOG00000021285 0.12 0.09 2.2e-04 0.05 0.03 0.04 0.03 9.1e-04 6.2e-03 3.0e-03 7.0e-03
4 Brain gene expression ENSRNOG00000021285 0.21 0.1 1.4e-15 0.1 0.15 0.17 0.09 2.4e-09 4.4e-14 5.4e-16 4.9e-09
5 Brain mRNA stability ENSRNOG00000021285 0.22 0.09 0.0e+00 0.22 0.23 0.24 0.13 7.3e-20 1.6e-21 4.5e-22 1.0e-11
6 IL gene expression ENSRNOG00000021285 0.26 0.14 3.1e-04 0.05 0.12 0.14 0.12 3.0e-02 7.5e-04 2.9e-04 1.1e-03
7 IL mRNA stability ENSRNOG00000021285 0.13 0.09 5.7e-03 0.12 0.04 0.05 0.11 9.2e-04 5.2e-02 2.4e-02 1.5e-03
8 LHb gene expression ENSRNOG00000021285 0.32 0.18 6.2e-04 0.04 0.07 0.08 0.05 3.6e-02 8.0e-03 7.5e-03 3.0e-02
9 NAcc gene expression ENSRNOG00000021285 0.18 0.12 8.2e-07 0.05 0.08 0.12 0.1 1.7e-04 1.5e-06 4.0e-09 3.8e-08
10 NAcc mRNA stability ENSRNOG00000021285 0.08 0.06 4.9e-05 0.06 0.06 0.04 0.06 2.2e-05 4.3e-05 3.2e-04 2.8e-05
11 PL gene expression ENSRNOG00000021285 0.1 0.06 2.1e-04 0.05 0.05 0.05 0.05 1.3e-04 1.1e-04 2.1e-04 1.2e-04
12 PL mRNA stability ENSRNOG00000021285 0.09 0.06 7.0e-07 0.04 0.04 0.04 0.05 6.1e-04 3.1e-04 2.7e-04 1.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail2.99.512.5-3.4-1.8-3.5-2.9-3.2-3.5-3.3-3.2-2.5-3.2-2.4-3.5
BMI without tail0.81.74.1-1.80.5-1.5-0.6-1.5-0.6-1.7-1.5-0.3-1.70.0-2.0
Body weight1.46.111.4-3.3-0.1-3.3-1.7-2.2-1.7-3.3-2.3-1.6-3.2-0.6-3.4
Epididymis fat weight0.10.31.3-0.8-0.2-1.2-0.2-0.2-0.3-0.8-0.3-0.5-0.70.1-0.5
Glucose0.20.30.6-0.6-0.8-0.3-0.70.5-0.4-0.70.3-0.2-0.7-0.40.7
Heart weight0.20.31.40.5-1.20.6-0.3-0.4-0.30.5-0.5-0.10.5-1.00.3
Left kidney weight10.129.045.9-5.8-2.5-5.8-4.8-6.0-4.2-6.0-6.1-5.4-6.0-3.6-6.8
Right kidney weight10.630.340.2-6.0-2.9-5.9-5.2-6.2-4.6-6.1-6.1-5.5-6.0-4.1-6.3
Tail length1.03.07.30.62.71.12.11.52.50.61.42.00.52.70.7
Length with tail0.20.82.1-1.01.5-0.90.50.30.9-1.10.20.3-1.21.4-0.6
Length without tail1.02.35.2-1.8-1.1-2.3-1.5-0.9-1.4-1.8-0.8-1.9-1.8-1.0-1.0
Liver weight, left0.30.40.7-0.4-0.7-0.6-0.5-0.8-0.7-0.5-0.9-0.4-0.4-0.7-0.8
Liver weight, right0.50.83.7-0.51.9-1.00.90.10.9-0.60.20.6-0.61.4-0.7
Parametrial fat weight1.12.24.21.12.11.12.01.01.41.21.12.01.11.90.6
Retroperitoneal fat weight1.34.410.0-2.60.0-3.2-1.5-2.2-1.4-2.6-2.0-1.6-2.7-0.5-2.6
Intraocular pressure0.50.73.4-0.11.8-0.80.70.10.5-0.30.40.9-0.31.3-0.5
Extensor digitorum longus weight0.21.01.8-1.0-0.4-1.3-0.7-1.1-0.6-1.0-1.2-1.1-1.0-0.4-1.4
Soleus weight0.30.81.6-0.7-1.0-1.1-1.0-0.7-1.3-0.8-0.8-0.7-0.8-0.9-0.7
Tibialis anterior weight0.10.30.90.7-1.00.70.1-0.0-0.00.8-0.2-0.10.9-0.50.1
Tibia length0.10.40.8-0.7-0.6-0.9-0.60.0-0.8-0.8-0.2-0.6-0.8-0.2-0.5
Number of licking bursts0.91.12.40.61.60.61.21.01.20.51.11.40.61.50.8
Food consumed during 24 hour testing period5.26.211.5-2.6-1.6-2.4-2.9-2.1-1.8-3.2-2.3-2.9-3.4-1.5-2.3
Times rat made contact with spout0.20.20.5-0.40.7-0.60.1-0.50.4-0.6-0.40.0-0.50.6-0.5
Mean time between licks in bursts1.01.42.11.20.81.41.11.31.51.31.21.01.21.20.8
Mean num. licks in bursts1.72.03.6-1.2-1.4-1.4-1.5-1.5-1.3-1.3-1.5-1.9-1.3-1.4-1.3
Std. dev. time between licks in bursts0.20.21.0-0.1-1.00.3-0.4-0.0-0.70.1-0.1-0.10.3-0.7-0.0
Water consumed over 24 hours2.73.25.3-1.9-1.3-1.6-2.1-1.7-1.1-2.3-1.7-2.2-2.3-1.1-1.7
Indifference point 0 sec0.10.10.8-0.10.5-0.10.20.4-0.2-0.20.50.9-0.10.30.1
Indifference point AUC0.20.20.40.20.50.50.60.70.20.40.60.30.50.40.4
Indifference point function ln k1.72.44.9-1.7-0.5-2.2-1.4-1.5-0.7-1.9-1.4-1.6-2.1-0.6-1.8
Indifference point function log k1.72.44.9-1.7-0.5-2.2-1.4-1.5-0.7-1.9-1.4-1.6-2.1-0.6-1.8
Delay discounting total patch changes 0 sec0.20.31.20.30.60.20.50.7-0.00.20.71.10.30.40.3
Delay discounting total patch changes 12 sec0.00.10.2-0.40.1-0.0-0.1-0.3-0.4-0.3-0.10.1-0.2-0.2-0.2
Delay discounting total patch changes 18 sec0.70.91.80.40.90.80.91.40.70.41.31.30.61.10.9
Delay discounting total patch changes 24 sec0.30.41.30.51.00.20.80.40.30.40.51.20.50.5-0.1
Delay discounting total patch changes 6 sec0.40.62.30.60.60.90.80.9-0.00.70.91.50.80.40.4
Delay discounting time to switch 0 sec0.10.20.60.4-0.80.8-0.2-0.3-0.00.4-0.5-0.10.4-0.60.3
Delay discounting water rate 0 sec0.30.51.1-1.0-0.2-0.8-0.7-0.5-0.9-1.0-0.5-0.5-0.9-0.4-0.7
Delay discounting water rate 12 sec0.30.51.2-0.61.1-1.00.40.40.1-0.80.50.5-0.81.0-0.4
Delay discounting water rate 18 sec0.10.20.6-0.50.3-0.4-0.30.4-0.1-0.80.30.3-0.80.4-0.1
Delay discounting water rate 24 sec0.40.61.3-0.8-0.4-1.2-0.9-0.5-0.9-1.0-0.4-0.5-1.0-0.6-0.6
Delay discounting water rate 6 sec0.40.71.7-0.21.2-0.00.71.01.0-0.11.00.9-0.21.30.7
Locomotor activity1.82.96.4-2.50.6-2.2-0.9-1.7-0.6-2.4-1.5-0.7-2.50.1-2.1
Locomotor testing distance0.30.51.0-1.00.4-0.9-0.2-0.60.0-1.0-0.50.0-1.00.4-0.9
Locomotor testing rearing0.40.61.3-1.10.2-0.9-0.3-0.80.2-1.0-0.9-0.8-0.90.3-1.0
Light reinforcement 10.30.62.0-0.91.0-0.40.5-0.40.1-0.9-0.5-0.1-0.80.8-1.4
Light reinforcement 22.33.16.1-2.2-0.3-2.5-1.2-1.5-1.5-2.2-1.6-1.6-2.2-0.5-2.1
Reaction time number correct0.40.60.90.60.70.70.90.90.80.60.70.80.70.80.6
Reaction time mean minus median0.40.50.70.50.80.70.70.80.70.70.80.80.70.80.6
Reaction time mean minus median AUC0.50.71.70.71.30.61.10.40.70.80.41.20.90.90.1
Reaction time num false alarms0.50.62.3-0.01.5-0.00.60.61.3-0.00.90.4-0.11.40.4
Reaction time num false alarms AUC0.60.82.9-0.11.7-0.20.80.61.5-0.01.00.4-0.11.60.4
Reaction time trials correct on left0.40.60.90.60.70.70.90.90.80.60.70.80.70.80.6
Reaction time trials on left0.40.60.90.60.70.80.91.00.80.60.70.80.80.80.6
Reaction time mean1.11.42.91.7-0.41.60.61.00.11.71.00.81.7-0.31.6
Reaction time mean AUC1.41.83.91.9-0.21.80.81.10.32.01.11.01.9-0.11.7
Median of all reaction times1.31.73.51.9-0.81.70.51.1-0.11.91.10.81.8-0.61.8
Reaction time omissions0.70.92.41.3-0.21.60.61.10.31.21.00.71.10.21.1
Reaction time false alarm rate0.20.31.1-0.41.0-0.60.1-0.10.8-0.50.4-0.1-0.60.90.0
Reaction time premature initiation rate1.92.56.3-0.9-2.5-0.8-2.0-1.4-1.9-1.0-1.5-1.7-1.0-2.3-0.5
Reaction time premature initiations0.71.03.6-0.5-1.9-0.2-1.3-0.7-1.2-0.5-1.0-1.0-0.4-1.6-0.0
Std. dev. reaction times0.70.91.41.10.61.10.91.00.71.21.11.01.20.51.2
Reaction time trials completed0.40.60.90.60.70.80.91.00.80.60.70.80.80.80.6
Reaction time trials AUC0.20.30.50.30.60.50.70.70.50.40.40.60.50.60.4
Social response proportion1.61.73.0-1.7-1.0-1.3-1.4-1.0-0.8-1.7-1.2-1.7-1.6-0.7-1.0
Social responses0.91.22.8-1.70.4-1.2-0.7-0.9-0.2-1.6-0.9-1.0-1.50.4-1.4
Social time0.91.13.00.21.40.51.11.31.40.21.31.10.31.70.6
Conditioned locomotion0.00.00.1-0.1-0.1-0.20.10.0-0.1-0.1-0.3-0.3-0.1-0.1-0.3
Cocaine response after cond. corrected0.20.30.8-0.40.7-0.70.10.40.1-0.40.50.5-0.50.9-0.3
Cocaine response after cond. not corrected0.50.62.1-0.01.3-0.30.80.70.70.10.80.9-0.11.5-0.1
Cocaine response before conditioning0.50.61.00.80.80.71.00.71.00.90.60.60.80.80.6
Saline control response0.30.41.4-0.7-0.5-0.9-0.50.3-0.2-0.70.3-1.2-0.7-0.1-0.1
Condit. Reinf. active minus inactive responses0.60.81.4-1.0-0.8-0.9-1.2-0.6-1.0-1.1-0.7-0.8-1.1-0.7-0.1
Condit. Reinf. active-inactive response ratio0.20.20.5-0.4-0.7-0.2-0.6-0.1-0.4-0.5-0.3-0.4-0.5-0.30.2
Condit. Reinf. active responses1.72.43.5-1.7-1.1-1.6-1.8-1.4-1.7-1.9-1.5-1.4-1.8-1.3-1.1
Condit. Reinf. inactive responses2.53.14.2-1.9-0.8-2.0-1.8-1.9-1.8-2.0-1.9-1.5-1.9-1.3-2.1
Condit. Reinf. lever presses0.60.91.4-0.9-0.8-0.8-0.9-1.0-1.0-0.9-1.2-0.9-0.9-0.8-1.0
Condit. Reinf. lever reinforcers received1.21.72.5-1.4-1.0-1.4-1.6-1.1-1.5-1.6-1.2-1.1-1.5-1.1-0.8
Pavlov. Cond. lever latency0.20.30.50.30.60.40.70.60.70.50.70.70.50.50.3
Pavlov. Cond. magazine entry latency0.91.03.21.3-1.80.9-0.30.4-0.91.30.1-0.21.1-1.31.2
Pavlov. Cond. change in total contacts1.11.54.1-0.4-2.0-0.2-1.7-0.9-1.7-0.7-1.1-1.2-0.7-1.70.2
Pavlov. Cond. index score0.40.52.00.3-1.40.2-0.7-0.3-1.00.2-0.5-0.60.1-1.10.4
Pavlov. Cond. latency score0.50.72.50.2-1.60.1-0.9-0.4-1.30.1-0.7-0.70.0-1.30.2
Pavlov. Cond. lever contacts0.71.01.8-0.5-1.4-0.7-1.3-1.0-1.4-0.7-1.1-1.2-0.7-1.2-0.5
Pavlov. Cond. magazine entry number0.50.62.2-0.81.5-0.60.50.20.7-0.70.40.5-0.51.2-0.7
Pavlov. Cond. intertrial magazine entries0.81.02.0-1.0-0.8-1.3-1.1-0.9-1.4-1.0-0.9-0.7-0.9-1.1-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.41.40.5-1.20.3-0.5-0.2-0.80.4-0.4-0.40.2-1.00.4
Pavlov. Cond. response bias0.50.62.10.0-1.5-0.1-1.0-0.6-1.2-0.2-0.8-0.9-0.2-1.20.0
Conditioned reinforcement - actives0.70.71.90.51.4-0.00.70.71.00.61.10.80.61.40.5
Conditioned reinforcement - inactives0.20.31.5-0.50.4-1.2-0.7-0.4-0.1-0.30.0-0.6-0.3-0.1-0.2
Conditioned locomotion0.91.12.9-1.40.5-1.7-0.8-0.8-0.6-1.3-0.6-0.6-1.30.2-1.3
Intermittent access intake day 1-15 change0.40.41.0-0.7-0.3-0.7-1.00.20.1-0.70.3-1.0-0.70.00.5
Intermittent access intake escalation0.60.61.6-0.9-0.3-1.3-1.2-0.2-0.2-0.90.1-1.2-0.9-0.10.1
Intermittent access intake escalation 20.50.51.5-0.8-1.0-0.6-1.20.2-0.3-0.70.3-1.0-0.7-0.40.8
Intermitt. access day 1 inactive lever presses1.21.33.2-0.5-1.4-0.6-1.4-1.3-1.6-0.5-1.3-1.0-0.5-1.8-0.8
Intermitt. access day 15 inactive lever presses3.23.55.6-1.7-1.3-2.2-2.4-1.8-2.3-1.7-1.6-1.8-1.7-1.9-1.6
Intermitt. access escalation Index0.20.20.7-0.30.1-0.8-0.3-0.5-0.3-0.5-0.2-0.1-0.5-0.2-0.6
Intermittent access day 1 total infusions0.91.03.6-1.11.2-1.9-0.6-1.1-0.2-0.9-0.5-0.6-0.90.4-1.2
Intermittent access day 15 total infusions1.21.45.3-1.40.4-2.3-1.3-1.0-0.4-1.3-0.4-1.4-1.30.0-0.9
Intermittent access terminal intake (last 3 days)2.52.88.2-2.10.0-2.9-1.9-1.4-0.9-2.0-0.9-1.8-2.0-0.3-1.3
Intermittent access total infusions2.12.36.9-1.90.3-2.6-1.6-1.4-0.8-1.8-0.8-1.6-1.8-0.2-1.4
Intermittent access day 1 locomotion0.50.52.5-0.51.6-1.30.2-0.40.3-0.30.20.3-0.30.9-0.5
Intermittent access day 15 total locomotion0.90.94.3-1.01.3-2.1-0.5-1.00.1-0.9-0.3-0.6-0.90.5-1.0
Intermittent access total locomotion1.11.24.9-1.30.6-2.2-1.0-1.2-0.5-1.1-0.7-1.0-1.1-0.1-1.0
Intermittent access standard deviation1.01.12.2-1.2-0.7-1.3-1.5-0.9-1.0-1.1-0.6-1.3-1.1-1.0-0.2
Cocaine induced anxiety3.03.55.8-1.4-1.8-1.6-2.0-2.1-2.4-1.5-2.1-1.5-1.5-2.3-1.8
Post-drug Anxiety3.53.88.5-1.1-2.6-1.3-2.1-1.9-2.8-1.1-2.1-1.6-1.1-2.9-1.4
Baseline Anxiety0.80.81.60.90.00.70.81.20.91.01.20.41.00.51.3
Lifetime Intake2.02.36.5-2.00.5-2.5-1.5-1.5-0.6-1.8-0.9-1.5-1.8-0.1-1.5
Incentive Sensitization - Responses0.90.82.0-0.2-0.9-0.9-1.3-1.1-1.3-0.2-0.8-1.1-0.2-1.4-0.3
Incentive Sensitization - Breakpoint0.90.92.0-0.3-0.8-0.9-1.3-1.2-1.3-0.3-0.9-1.1-0.3-1.4-0.4
Progressive ratio test 1 active lever presses0.80.94.8-0.32.2-1.20.5-0.30.5-0.20.40.9-0.21.4-0.7
Progressive ratio test 1 breakpoint0.90.95.1-0.32.2-1.10.5-0.20.5-0.10.41.0-0.11.4-0.7
Progressive ratio test 1 inactive lever presses0.30.31.40.11.2-0.80.3-0.70.00.2-0.30.30.20.2-0.8
Progressive ratio test 2 active lever presses0.20.31.1-0.00.3-1.1-0.6-0.8-0.70.1-0.2-0.40.1-0.4-0.1
Progressive ratio test 2 breakpoint0.20.20.8-0.10.3-0.9-0.6-0.8-0.70.0-0.2-0.40.0-0.5-0.1
Progressive ratio test 2 inactive lever presses0.91.03.3-0.7-0.0-1.8-1.2-1.5-1.1-0.4-0.7-1.2-0.4-0.9-0.8
Total sessions with >9 infusions1.51.73.9-2.00.7-1.8-1.1-1.00.1-1.8-0.7-1.2-1.80.6-1.3
Short access day 1 total inactive lever presses2.32.54.5-1.9-0.2-2.0-1.6-1.8-1.2-1.6-1.5-1.6-1.6-0.8-2.1
Short access day 10 total inactive lever presses1.11.21.7-1.1-1.0-1.1-1.3-0.9-1.3-1.1-1.1-1.0-1.1-1.2-0.8
Short access day 1 total infusions1.11.22.4-1.60.5-1.1-1.0-1.00.2-1.5-0.9-1.0-1.50.3-1.3
Short access day 10 total infusions1.71.95.3-1.81.0-2.3-1.1-1.1-0.7-1.7-0.6-0.8-1.70.3-1.6
Short access total infusions3.03.36.2-2.40.4-2.5-1.8-1.9-1.0-2.2-1.4-1.7-2.2-0.3-2.1
Short access day 1 locomotion0.20.20.6-0.5-0.2-0.3-0.8-0.3-0.2-0.5-0.3-0.6-0.5-0.1-0.2
Short access day 10 total locomotion0.80.94.10.12.0-0.20.90.21.10.20.51.00.21.6-0.2
Short access total locomotion0.80.81.8-1.20.5-1.3-0.9-1.0-0.6-1.0-0.7-0.7-1.0-0.1-1.3
Compulsive drug intake0.50.52.70.5-1.70.8-0.3-0.0-0.20.5-0.3-0.50.5-1.00.6
One hour access (0.3 mA shock)0.30.31.3-0.60.4-1.2-0.5-0.7-0.0-0.4-0.3-0.9-0.40.1-0.6
One hour access (shock baseline)0.80.93.5-1.11.3-1.9-0.6-0.6-0.1-1.0-0.1-0.7-1.00.6-1.0
Number of responses in last shaping day0.10.10.2-0.30.00.4-0.4-0.20.2-0.4-0.1-0.2-0.40.1-0.3
Context. condit. distance diff. score1.01.22.3-1.0-0.6-1.2-0.9-1.5-0.6-1.0-1.4-1.5-1.0-1.0-1.4
Locomotion velocity, session 10.60.61.5-1.20.6-0.8-0.5-0.30.4-1.1-0.50.0-1.20.7-1.1
Locomotion distance, session 10.50.71.90.50.80.80.80.91.40.60.70.80.51.10.3
Locomotion velocity, session 21.41.73.5-1.80.8-1.7-0.6-1.2-0.5-1.7-1.2-0.4-1.80.5-1.9
Locomotion distance, session 20.10.10.30.6-0.50.5-0.00.2-0.10.60.00.20.5-0.20.2
Locomotion velocity, session 30.91.13.0-0.91.7-0.90.5-0.61.3-1.0-0.6-0.1-1.01.5-1.2
Locomotion distance, session 30.80.92.60.41.60.21.20.81.40.30.60.70.21.60.2
Stereotopy head waving bouts, day 30.60.81.9-1.00.0-0.4-0.8-1.4-0.3-1.0-1.3-0.2-1.0-0.5-1.2
Stereotopy head waving duration, day 31.72.04.0-1.5-0.4-0.9-1.4-2.0-0.7-1.5-2.0-0.9-1.5-1.0-2.0
Locomotion velocity, session 70.50.51.4-0.70.9-0.60.3-1.00.3-0.7-1.0-0.2-0.70.5-1.2
Locomotion distance, session 70.10.20.90.01.0-0.50.7-0.00.30.00.10.2-0.00.7-0.2
Stereotopy head waving bouts, day 70.70.81.7-0.90.2-0.8-0.6-1.3-0.1-0.9-1.3-0.7-0.9-0.3-1.3
Stereotopy head waving duration, day 70.20.30.9-0.40.3-0.4-0.2-0.80.1-0.4-0.7-0.3-0.4-0.1-0.9
Locomotion velocity, session 84.35.16.9-2.5-1.0-2.6-2.3-2.5-1.8-2.5-2.5-2.0-2.6-1.6-2.6
Locomotion distance, session 80.30.40.8-0.7-0.0-0.9-0.4-0.8-0.2-0.7-0.7-0.9-0.7-0.3-0.9
Degree of sensitization distance1.41.42.6-1.1-1.0-1.3-1.3-1.3-1.6-1.1-1.0-1.0-1.1-1.4-0.8
Degree of sensitization stereotypy0.30.40.7-0.6-0.1-0.7-0.5-0.7-0.1-0.7-0.8-0.8-0.7-0.2-0.8
Condit. Reinf. active minus inactive responses0.30.30.8-0.00.30.50.10.80.2-0.00.90.8-0.00.50.8
Condit. Reinf. active-inactive response ratio0.70.72.00.60.31.20.51.00.70.61.11.00.70.41.4
Condit. Reinf. active responses1.31.63.10.91.41.01.21.41.10.81.61.80.91.51.2
Condit. Reinf. inactive responses1.01.22.61.01.60.31.31.01.00.91.11.30.91.50.5
Incentive salience index mean0.40.51.1-0.71.0-0.20.10.70.4-0.80.80.6-0.71.00.1
Condit. Reinf. lever presses0.71.02.3-1.31.5-1.00.10.30.5-1.30.40.2-1.31.4-0.9
Time in familiar zone, hab. session 10.90.91.8-1.10.1-1.1-0.8-1.0-0.8-1.1-0.9-0.6-1.1-0.5-1.3
Time in novel zone, hab. session 10.20.21.00.1-1.00.5-0.40.10.10.00.0-0.80.1-0.30.4
Total zone transitions, hab. session 11.31.93.51.7-0.01.91.11.51.21.71.30.91.70.61.5
Total locomotion distance, hab. session 10.20.20.80.40.60.40.70.20.90.40.30.20.40.6-0.1
Locomotion velocity, hab. session 10.20.30.90.40.80.40.80.31.00.40.30.30.40.8-0.1
Time in familiar zone, hab. session 20.20.20.9-0.10.3-0.40.50.30.6-0.10.3-0.5-0.01.0-0.2
Time in novel zone, hab. session 20.20.20.70.3-0.30.8-0.40.3-0.00.30.20.50.2-0.60.8
Total zone transitions, hab. session 20.50.71.8-0.3-1.3-0.3-0.9-0.7-1.0-0.2-0.8-1.1-0.2-1.1-0.7
Total locomotion distance, hab. session 20.10.20.5-0.4-0.4-0.3-0.3-0.3-0.4-0.4-0.4-0.7-0.3-0.4-0.5
Locomotion velocity, hab. session 20.10.10.4-0.3-0.4-0.2-0.3-0.2-0.3-0.3-0.4-0.6-0.2-0.3-0.4
Novel to familiar place preference ratio0.20.21.10.3-0.21.10.10.30.90.30.1-0.10.30.20.4
Novelty place preference0.10.20.90.0-0.10.8-0.00.11.00.0-0.1-0.3-0.00.30.1
Time in novel zone, NPP test0.20.21.1-0.0-0.31.0-0.00.11.10.1-0.1-0.50.10.30.2
Total zone transitions, NPP test0.81.22.81.5-0.11.01.11.10.71.70.90.61.70.31.0
Total locomotion distance, NPP test0.20.30.70.80.60.30.70.50.40.80.40.30.80.30.4
Locomotion velocity, NPP test0.40.61.11.00.90.31.10.60.51.00.60.71.00.60.4
Pavlov. Cond. lever latency0.50.71.41.1-0.91.00.2-0.6-0.31.2-0.5-0.21.2-1.10.4
Pavlov. Cond. magazine entry latency0.20.20.8-0.3-0.60.1-0.40.9-0.1-0.30.7-0.2-0.30.40.7
Pavlov. Cond. change in total contacts0.50.51.3-1.1-0.3-0.6-1.00.5-0.8-1.10.3-0.0-1.10.00.2
Pavlov. Cond. index score0.30.30.8-0.9-0.1-0.7-0.60.6-0.2-0.90.5-0.2-0.90.50.1
Pavlov. Cond. latency score0.30.41.2-1.0-0.1-0.8-0.70.4-0.2-1.10.3-0.4-1.10.4-0.1
Pavlov. Cond. lever contacts0.91.12.3-1.51.2-1.4-0.20.50.3-1.50.50.2-1.51.3-0.6
Pavlov. Cond. magazine entry number0.20.20.60.40.50.30.3-0.80.20.4-0.60.30.4-0.4-0.6
Pavlov. Cond. intertrial magazine entries0.91.12.21.01.00.80.91.20.61.01.51.51.10.71.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.70.2-0.5-0.30.80.0-0.70.70.1-0.70.70.3
Pavlov. Cond. response bias0.50.61.1-1.00.6-0.9-0.20.9-0.0-1.00.80.1-1.01.10.1
Bone: apparent density0.50.91.91.4-0.00.90.51.10.61.11.00.91.00.41.3
Bone surface0.20.30.70.8-0.20.70.20.70.50.60.50.60.50.40.8
Bone volume0.40.71.51.20.20.90.60.90.80.90.80.80.80.61.0
Bone: connectivity density0.50.71.40.90.50.80.50.90.80.80.91.20.60.81.1
Bone: cortical apparent density0.60.71.81.1-0.41.30.60.70.51.00.70.31.20.11.1
Bone: cortical area1.92.94.5-1.6-1.7-1.7-1.9-1.5-1.6-1.9-1.6-2.1-1.9-1.4-1.4
Bone: cortical porosity1.81.93.1-1.6-1.1-1.7-1.7-1.0-1.5-1.7-0.9-1.4-1.7-1.1-1.0
Bone: cortical porosity1.71.93.0-1.6-1.0-1.5-1.7-1.0-1.5-1.6-0.9-1.3-1.7-1.2-0.9
Bone: cortical thickness0.40.62.8-0.3-1.7-0.2-0.9-0.3-0.9-0.5-0.4-1.1-0.4-1.10.0
Bone: cortical thickness3.33.96.0-1.7-2.1-1.5-2.4-1.8-2.0-1.9-1.8-2.4-1.9-2.2-1.4
Bone: cortical tissue density0.40.51.41.0-0.41.20.50.60.40.80.60.21.0-0.01.0
Bone: elastic displacement0.30.31.1-0.71.1-0.70.10.10.2-0.70.30.3-0.50.7-0.8
Bone: elastic work3.24.16.0-2.3-1.1-2.3-2.1-2.0-1.7-2.4-2.0-1.9-2.3-1.5-2.2
Bone: endosteal estimation1.53.35.4-1.8-0.4-2.2-1.7-2.2-1.4-2.0-2.0-1.6-2.2-1.1-2.3
Bone: endosteal perimeter2.34.88.4-2.5-0.4-2.8-2.0-2.2-1.5-2.7-2.1-2.0-2.9-0.9-2.6
Bone: final force2.03.26.4-0.9-2.5-1.3-2.1-1.5-2.2-1.2-1.8-2.1-1.3-2.3-1.3
Bone: final moment2.54.28.5-1.1-2.9-1.5-2.4-1.8-2.5-1.4-2.1-2.4-1.4-2.6-1.6
Bone: marrow area1.53.35.4-1.8-0.4-2.2-1.7-2.2-1.4-2.0-2.0-1.6-2.1-1.1-2.3
Bone: maximum diameter5.510.114.6-3.5-1.7-3.7-3.2-3.2-2.7-3.7-3.1-3.3-3.8-2.1-3.3
Bone: maximum force2.74.78.4-1.2-2.9-1.5-2.6-2.1-2.6-1.5-2.2-2.4-1.6-2.8-1.7
Bone: maximum moment3.35.810.7-1.4-3.3-1.6-2.8-2.3-2.8-1.7-2.5-2.7-1.7-3.1-2.0
Bone: minimum diameter1.12.14.2-1.8-0.0-2.0-1.2-1.3-0.7-1.9-1.2-1.5-2.1-0.3-1.6
Bone: periosteal estimation2.44.96.7-2.2-1.3-2.4-2.3-2.4-1.9-2.5-2.3-2.4-2.6-1.6-2.4
Bone: periosteal perimeter3.25.29.8-2.8-0.6-2.9-2.1-2.1-1.5-3.0-2.1-2.4-3.1-0.8-2.5
Bone: post-yield work0.40.51.70.8-1.30.9-0.40.1-0.70.8-0.30.00.6-1.00.5
Bone: stiffness2.03.111.90.2-3.50.1-2.1-1.1-2.3-0.0-1.5-1.9-0.2-3.0-0.1
Bone: tissue strength0.50.52.00.6-1.40.4-0.50.0-1.00.4-0.2-0.00.6-1.10.0
Bone: trabecular number1.01.52.41.21.01.01.01.61.41.11.51.40.91.31.3
Bone: trabecular spacing2.73.55.8-2.1-0.7-1.8-1.6-2.4-1.9-2.0-2.3-1.6-1.9-1.4-2.3
Bone: trabecular thickness0.20.20.50.60.50.20.40.50.70.40.70.30.30.50.6
Bone: trabecular tissue density0.60.92.01.4-0.91.40.30.40.11.30.40.11.3-0.51.2
Breakpoint value in progressive ratio session0.30.41.30.3-1.1-0.1-0.7-0.4-0.90.1-0.5-0.50.2-1.10.2
Distance traveled before self-admin0.10.10.7-0.10.8-0.40.5-0.30.30.0-0.10.30.00.5-0.4
Distance traveled after self-admin0.91.01.7-0.9-0.8-1.2-1.1-1.1-1.0-0.9-1.0-1.3-1.0-0.8-1.0
Delta time in closed arm before/after self-admin0.30.30.6-0.5-0.8-0.0-0.6-0.5-0.7-0.3-0.5-0.7-0.2-0.8-0.1
Delta time in open arm before/after self-admin0.80.72.20.51.50.41.20.51.40.40.60.40.41.30.1
Diff in mean of infusions in LGA sessions0.80.92.9-0.3-1.2-1.0-1.2-0.4-1.7-0.6-0.5-0.6-0.7-1.5-0.2
Extinction: sum of active levers before priming0.20.20.40.6-0.5-0.1-0.10.1-0.60.60.20.10.7-0.40.5
Active lever presses in extinction session 61.51.54.0-0.5-1.1-1.1-1.3-1.4-2.0-0.7-1.4-0.9-0.8-1.5-1.2
Delta distance traveled before/after self-admin0.30.40.7-0.6-0.4-0.5-0.6-0.6-0.4-0.6-0.7-0.8-0.7-0.3-0.7
Delta ambulatory time before/after self-admin0.40.40.8-0.5-0.5-0.5-0.7-0.6-0.6-0.6-0.6-0.9-0.7-0.4-0.7
Time in closed arm before self-admin0.30.30.90.4-0.70.1-0.40.9-0.20.40.90.20.4-0.31.0
Time in closed arm after self-admin0.10.10.4-0.5-0.4-0.2-0.6-0.0-0.1-0.40.0-0.5-0.4-0.30.1
Time in open arm before self-admin0.91.02.40.91.50.91.50.21.00.80.21.31.01.0-0.0
Time in open arm after self-admin0.80.82.31.21.20.91.50.10.61.00.01.11.10.6-0.1
Sum of active levers in priming session hrs 5-60.70.71.60.1-1.2-0.3-1.1-0.8-1.2-0.2-0.8-0.9-0.2-1.20.0
Time to tail flick, vehicle, before self-admin0.40.51.10.81.00.50.80.30.70.50.51.00.50.70.1
Time to tail flick, vehicle, after self-admin0.10.10.5-0.30.2-0.7-0.40.10.1-0.40.2-0.1-0.40.3-0.1
Time to tail flick, test, before self-admin0.90.92.2-1.50.5-1.2-0.6-0.50.4-1.4-0.4-0.8-1.40.5-0.9
Time to tail flick, test, after self-admin0.40.41.4-0.5-1.1-0.4-1.20.3-0.6-0.40.4-0.8-0.5-0.60.6
Delta time to tail flick, vehicle, before/after SA1.00.91.5-1.0-1.1-0.9-1.2-0.9-1.1-0.8-0.9-1.1-0.8-1.1-0.5
Delta time to tail flick, test, before/after SA0.90.81.91.1-1.00.9-0.21.0-0.51.11.00.41.0-0.71.4
Ambulatory time before self-admin0.20.20.90.20.9-0.10.7-0.10.60.30.10.40.30.6-0.2
Ambulatory time after self-admin0.20.20.5-0.3-0.6-0.5-0.6-0.4-0.5-0.2-0.3-0.7-0.3-0.4-0.4
Total heroin consumption1.01.23.7-0.2-1.3-0.9-1.0-1.2-1.9-0.3-1.2-0.8-0.3-1.7-0.9
Area under the delay curve3.74.07.72.41.02.51.91.91.12.41.92.82.31.01.9
Delay disc. indifference point, 0s delay0.10.10.50.20.20.10.20.0-0.00.30.10.70.30.1-0.3
Delay disc. indifference point, 16s delay3.33.46.42.10.22.51.62.01.22.21.72.22.10.82.1
Delay disc. indifference point, 2s delay0.50.61.40.90.31.00.60.60.10.90.71.21.00.10.6
Delay disc. indifference point, 24s delay0.10.10.6-0.2-0.40.1-0.50.1-0.8-0.30.00.3-0.3-0.5-0.3
Delay disc. indifference point, 4s delay4.44.69.52.51.23.02.11.71.02.71.73.12.70.81.8
Delay disc. indifference point, 8s delay3.43.56.22.41.02.31.81.61.02.31.72.52.20.71.8
Delay discount exponential model param3.94.28.4-2.4-1.1-2.5-1.9-2.0-1.1-2.4-1.9-2.9-2.3-1.0-1.9
Delay discount hyperbolic model param3.63.98.0-2.3-1.1-2.5-1.9-1.8-1.0-2.3-1.8-2.8-2.3-1.0-1.8
Fecal boli incidents, locomotor time 10.10.10.20.10.3-0.40.3-0.3-0.30.1-0.40.20.00.0-0.5
Change in fecal boli incidents, locomotor task0.40.30.90.30.40.80.50.81.00.10.60.40.20.70.4
Time >=10cm from walls, locomotor time 10.40.41.1-0.4-0.7-0.0-0.5-0.8-0.7-0.5-1.1-0.7-0.4-0.7-0.8
Bouts of movement, locomotor time 10.50.51.1-0.6-0.4-1.0-0.9-0.7-0.9-0.8-0.6-0.6-0.8-0.6-0.6
Total resting periods, locomotor time 10.50.61.6-0.3-0.9-0.7-1.0-0.7-1.3-0.6-0.6-0.7-0.6-1.0-0.4
Rest time, locomotor task time 10.30.40.7-0.6-0.0-0.8-0.4-0.9-0.7-0.5-0.8-0.1-0.5-0.3-0.8
Distance moved, locomotor task time 10.10.10.3-0.1-0.2-0.0-0.1-0.3-0.3-0.1-0.3-0.2-0.1-0.2-0.5
Vertical activity count, locomotor time 10.10.20.7-0.2-0.80.3-0.5-0.0-0.4-0.2-0.2-0.4-0.3-0.6-0.1
Time >=10cm from walls, locomotor time 21.11.22.1-1.2-1.4-0.7-1.3-0.7-1.3-1.0-0.8-1.4-1.0-1.1-0.9
Bouts of movement, locomotor time 20.40.51.30.9-0.50.80.30.3-0.31.10.30.61.1-0.60.5
Total resting periods, locomotor time 20.50.61.41.1-0.20.80.40.4-0.21.20.50.81.2-0.50.7
Rest time, locomotor task time 24.55.39.12.02.52.02.72.22.31.92.13.01.92.81.8
Distance moved, locomotor task time 23.43.95.7-2.1-1.4-2.2-2.1-2.1-1.7-1.9-2.0-2.4-2.0-1.8-2.1
Vertical activity count, locomotor time 24.44.86.1-2.5-1.6-2.2-2.5-2.1-2.0-2.3-2.1-2.5-2.4-2.0-2.2
Weight adjusted by age2.62.94.8-2.1-1.4-1.1-1.9-1.5-1.3-2.2-1.6-1.9-2.1-1.1-1.8
Seeking ratio, delayed vs. immediate footshock0.70.91.71.3-0.21.20.71.00.31.30.80.71.30.11.0
Locomotion in novel chamber1.82.25.20.82.11.31.91.32.20.81.21.40.82.30.4
Locomotion in novel chamber post-restriction0.10.10.30.3-0.00.10.2-0.2-0.20.5-0.20.20.6-0.3-0.4
Progressive ratio0.60.71.70.71.00.80.70.80.70.80.71.30.80.70.9
Food seeking constrained by brief footshock0.81.01.5-1.0-0.8-1.0-0.8-1.0-1.2-1.0-1.1-0.8-0.9-0.9-1.1
Seeking ratio, punishment vs. effort2.02.54.2-1.2-2.0-1.3-1.4-1.4-1.9-1.2-1.5-1.9-1.2-1.8-1.5
Run reversals in cocaine runway, females0.70.71.90.10.90.80.81.01.30.11.00.80.01.40.5
Run reversals in cocaine runway, males0.50.52.5-0.41.6-0.30.40.11.0-0.20.10.3-0.31.2-0.3
Latency to leave start box in cocaine runway1.51.72.8-1.5-0.2-1.7-1.3-1.5-0.9-1.5-1.2-1.2-1.4-0.8-1.6
Latency to leave start box in cocaine runway, F0.70.81.6-0.9-0.2-1.0-0.9-1.1-0.4-1.0-0.8-0.9-0.9-0.5-1.3
Latency to leave start box in cocaine runway, M1.81.72.9-1.7-0.3-1.7-1.3-1.2-1.1-1.5-1.1-1.4-1.5-0.9-1.2
Cd content in liver0.10.10.30.3-0.20.1-0.00.5-0.20.40.50.30.4-0.20.6
Co content in liver0.50.61.5-1.20.3-0.8-0.6-0.7-0.2-1.2-0.5-0.7-1.20.1-0.8
Cu content in liver5.97.112.73.60.73.12.62.71.53.62.52.63.61.22.5
Fe content in liver0.30.40.6-0.7-0.7-0.8-0.7-0.0-0.6-0.7-0.3-0.8-0.7-0.3-0.3
K content in liver0.30.31.00.1-0.6-0.3-0.5-0.2-1.0-0.00.0-0.4-0.1-0.9-0.3
Mg content in liver0.20.31.10.2-0.8-0.5-0.5-0.0-1.10.20.1-0.10.1-0.9-0.1
Mn content in liver0.70.71.6-1.11.0-1.2-0.0-0.60.0-1.2-0.3-0.6-1.10.5-1.2
Na content in liver1.51.63.31.7-0.31.80.91.20.61.61.30.81.70.11.6
Rb content in liver0.30.41.30.8-1.20.7-0.10.2-0.50.70.2-0.10.7-0.70.3
Se content in liver0.30.40.90.51.0-0.30.60.80.50.30.80.60.20.90.2
Sr content in liver2.22.03.31.31.71.11.71.11.81.31.11.61.31.71.0
Zn content in liver1.01.11.91.00.71.01.01.41.21.11.11.11.01.00.8