Hub : Genes

Hspb6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020922	0.11	0.06	5.7e-09	0.06	0.07	0.06	0.07	4e-07	2.1e-08	1.4e-07	3.0e-08
2	Brain	gene expression	ENSRNOG00000020922	0.19	0.09	5.6e-17	0.17	0.18	0.18	0.18	3e-15	2.5e-16	3.6e-16	4.5e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.1	0.3	0.5	0.4	-0.7
BMI without tail	0.0	0.0	0.0	-0.1	0.1
Body weight	2.4	10.1	14.0	-2.5	3.7
Epididymis fat weight	0.2	0.4	0.5	-0.7	0.5
Glucose	0.3	0.5	1.0	1.0	0.1
Heart weight	0.4	0.6	1.1	-1.1	0.2
Left kidney weight	2.6	7.4	13.2	-1.3	3.6
Right kidney weight	4.2	11.9	19.3	-2.1	4.4
Tail length	3.4	10.3	14.1	-2.6	3.8
Length with tail	6.7	24.5	30.4	-4.3	5.5
Length without tail	5.3	11.7	13.2	-3.2	3.6
Liver weight, left	0.7	1.1	2.2	1.5	-0.2
Liver weight, right	0.3	0.5	0.8	0.9	-0.5
Parametrial fat weight	1.5	2.9	5.2	2.3	0.8
Retroperitoneal fat weight	1.4	4.6	8.1	2.8	-1.1
Intraocular pressure	0.1	0.1	0.1	-0.4	-0.2
Extensor digitorum longus weight	0.4	1.5	2.8	1.7	0.6
Soleus weight	0.1	0.4	0.7	0.8	-0.2
Tibialis anterior weight	0.5	1.7	2.3	1.5	1.0
Tibia length	2.9	8.1	10.2	-2.5	3.2
Number of licking bursts	2.1	2.5	4.4	0.7	-2.1
Food consumed during 24 hour testing period	1.2	1.4	2.7	-1.6	0.3
Times rat made contact with spout	0.7	0.9	1.7	1.3	0.1
Mean time between licks in bursts	0.2	0.2	0.2	-0.4	-0.5
Mean num. licks in bursts	1.5	1.8	3.5	0.2	1.9
Std. dev. time between licks in bursts	1.5	1.8	2.6	-1.6	-1.0
Water consumed over 24 hours	0.5	0.6	0.7	-0.6	0.9
Indifference point 0 sec	0.1	0.2	0.3	-0.6	-0.2
Indifference point AUC	0.5	0.6	0.8	0.9	-0.6
Indifference point function ln k	0.3	0.5	0.5	-0.7	0.7
Indifference point function log k	0.3	0.5	0.5	-0.7	0.7
Delay discounting total patch changes 0 sec	0.2	0.3	0.6	-0.8	-0.1
Delay discounting total patch changes 12 sec	0.2	0.2	0.3	0.4	-0.5
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	-0.5	-0.3
Delay discounting total patch changes 24 sec	1.2	1.5	2.3	-1.5	0.8
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	-0.1	-0.3
Delay discounting time to switch 0 sec	0.9	1.4	2.1	1.4	-0.8
Delay discounting water rate 0 sec	0.5	0.7	1.3	0.3	-1.2
Delay discounting water rate 12 sec	0.9	1.3	2.4	-1.5	0.5
Delay discounting water rate 18 sec	0.2	0.3	0.5	0.2	-0.7
Delay discounting water rate 24 sec	1.2	1.6	2.9	-1.7	-0.6
Delay discounting water rate 6 sec	1.9	2.8	5.1	-2.3	0.7
Locomotor activity	1.1	1.7	3.1	1.8	-0.5
Locomotor testing distance	0.6	1.0	1.8	1.4	-0.5
Locomotor testing rearing	1.3	2.0	2.5	1.6	-1.3
Light reinforcement 1	0.2	0.3	0.6	-0.3	-0.8
Light reinforcement 2	2.2	2.9	3.5	1.5	-1.9
Reaction time number correct	0.0	0.0	0.1	0.1	0.2
Reaction time mean minus median	0.4	0.5	0.8	-0.5	0.9
Reaction time mean minus median AUC	1.0	1.2	1.9	-0.7	1.4
Reaction time num false alarms	0.5	0.7	0.9	0.7	-0.9
Reaction time num false alarms AUC	0.8	1.1	1.3	0.9	-1.1
Reaction time trials correct on left	0.0	0.0	0.1	0.1	0.2
Reaction time trials on left	0.0	0.0	0.1	0.1	0.3
Reaction time mean	0.3	0.4	0.4	-0.5	0.6
Reaction time mean AUC	0.1	0.2	0.2	-0.3	0.5
Median of all reaction times	0.1	0.1	0.1	-0.4	0.3
Reaction time omissions	0.1	0.1	0.2	0.4	0.1
Reaction time false alarm rate	0.5	0.7	1.1	0.6	-1.0
Reaction time premature initiation rate	0.5	0.6	0.8	-0.9	-0.7
Reaction time premature initiations	0.3	0.4	0.6	-0.8	-0.5
Std. dev. reaction times	0.9	1.2	1.2	-1.1	1.1
Reaction time trials completed	0.0	0.0	0.1	0.1	0.3
Reaction time trials AUC	0.1	0.1	0.2	0.4	0.3
Social response proportion	1.5	1.6	1.8	-1.4	1.1
Social responses	0.2	0.3	0.5	-0.7	0.3
Social time	3.0	4.0	5.5	-2.3	1.6
Conditioned locomotion	0.6	0.7	1.1	0.5	-1.1
Cocaine response after cond. corrected	0.7	0.8	1.6	1.3	0.1
Cocaine response after cond. not corrected	1.0	1.1	2.1	1.5	0.3
Cocaine response before conditioning	0.8	1.0	1.2	-1.0	1.1
Saline control response	0.1	0.1	0.2	0.4	0.2
Condit. Reinf. active minus inactive responses	0.8	1.0	1.2	-1.1	0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.1
Condit. Reinf. active responses	2.6	3.6	4.7	-2.2	1.6
Condit. Reinf. inactive responses	4.0	4.9	8.0	-2.8	1.4
Condit. Reinf. lever presses	5.0	6.9	7.8	-2.5	2.8
Condit. Reinf. lever reinforcers received	3.1	4.3	6.1	-2.5	1.6
Pavlov. Cond. lever latency	4.1	5.6	6.3	2.5	-2.2
Pavlov. Cond. magazine entry latency	1.8	2.0	2.6	-1.6	1.2
Pavlov. Cond. change in total contacts	7.3	10.2	12.6	-3.5	2.8
Pavlov. Cond. index score	4.0	5.3	6.1	-2.5	2.1
Pavlov. Cond. latency score	3.7	4.7	5.8	-2.4	1.9
Pavlov. Cond. lever contacts	4.0	5.5	6.4	-2.5	2.1
Pavlov. Cond. magazine entry number	3.3	4.0	4.1	2.0	-2.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.0	1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	3.8	5.0	5.4	-2.3	2.1
Pavlov. Cond. response bias	4.8	6.6	8.0	-2.8	2.3
Conditioned reinforcement - actives	0.2	0.2	0.3	0.2	-0.6
Conditioned reinforcement - inactives	2.1	2.4	4.7	-2.2	-0.4
Conditioned locomotion	1.9	2.3	4.2	0.6	-2.1
Intermittent access intake day 1-15 change	2.7	2.6	3.2	-1.4	1.8
Intermittent access intake escalation	2.8	2.8	3.0	-1.6	1.7
Intermittent access intake escalation 2	1.4	1.4	1.9	-0.9	1.4
Intermitt. access day 1 inactive lever presses	2.2	2.4	3.0	-1.7	1.4
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.6	-1.3	-0.0
Intermitt. access escalation Index	0.2	0.1	0.2	-0.4	-0.4
Intermittent access day 1 total infusions	2.0	2.3	4.6	0.0	-2.1
Intermittent access day 15 total infusions	1.1	1.2	1.9	-1.4	-0.7
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.4	-1.0	-1.2
Intermittent access total infusions	1.2	1.3	2.0	-0.8	-1.4
Intermittent access day 1 locomotion	1.8	1.8	3.3	-0.6	-1.8
Intermittent access day 15 total locomotion	1.2	1.3	2.2	-1.5	-0.6
Intermittent access total locomotion	1.4	1.6	3.2	-0.2	-1.8
Intermittent access standard deviation	5.2	5.6	7.8	-2.8	1.8
Cocaine induced anxiety	0.3	0.4	0.6	-0.3	0.8
Post-drug Anxiety	0.3	0.3	0.5	0.7	-0.3
Baseline Anxiety	1.3	1.3	2.2	0.7	-1.5
Lifetime Intake	0.7	0.8	1.6	-0.3	-1.3
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	-0.2
Progressive ratio test 1 active lever presses	1.4	1.5	2.9	-1.7	0.0
Progressive ratio test 1 breakpoint	1.5	1.5	2.9	-1.7	0.3
Progressive ratio test 1 inactive lever presses	1.7	1.8	3.5	-1.9	-0.3
Progressive ratio test 2 active lever presses	0.6	0.6	1.1	-1.1	-0.4
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	-0.9	-0.5
Progressive ratio test 2 inactive lever presses	2.6	3.0	5.8	-2.4	-0.4
Total sessions with >9 infusions	0.9	1.0	1.3	0.8	-1.1
Short access day 1 total inactive lever presses	1.6	1.8	3.2	-1.8	-0.6
Short access day 10 total inactive lever presses	1.3	1.5	2.3	-1.5	0.8
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.4
Short access day 10 total infusions	0.3	0.3	0.5	0.2	-0.7
Short access total infusions	0.6	0.7	0.9	0.7	-1.0
Short access day 1 locomotion	0.1	0.2	0.3	0.2	-0.5
Short access day 10 total locomotion	1.2	1.4	2.7	-1.6	-0.2
Short access total locomotion	1.0	1.0	1.8	0.4	-1.3
Compulsive drug intake	0.0	0.0	0.0	-0.2	0.1
One hour access (0.3 mA shock)	2.2	2.5	5.1	-2.3	0.0
One hour access (shock baseline)	0.7	0.8	1.3	-1.1	-0.6
Number of responses in last shaping day	0.8	0.8	0.9	-0.9	-0.8
Context. condit. distance diff. score	0.2	0.2	0.4	-0.6	-0.1
Locomotion velocity, session 1	0.8	0.9	1.6	1.3	-0.3
Locomotion distance, session 1	0.7	1.0	1.5	-1.2	0.7
Locomotion velocity, session 2	0.8	1.0	1.4	0.8	-1.2
Locomotion distance, session 2	0.9	1.2	2.4	0.2	-1.6
Locomotion velocity, session 3	0.2	0.2	0.4	0.3	-0.6
Locomotion distance, session 3	3.9	4.2	7.7	-2.8	0.9
Stereotopy head waving bouts, day 3	1.7	2.0	3.8	1.9	-0.5
Stereotopy head waving duration, day 3	2.6	3.2	5.5	2.3	-0.9
Locomotion velocity, session 7	0.7	0.8	1.4	-1.2	0.4
Locomotion distance, session 7	0.2	0.3	0.3	-0.6	0.5
Stereotopy head waving bouts, day 7	0.9	1.1	2.1	0.2	-1.4
Stereotopy head waving duration, day 7	1.9	2.3	3.0	1.3	-1.7
Locomotion velocity, session 8	2.7	3.2	5.4	1.0	-2.3
Locomotion distance, session 8	0.7	1.0	1.7	-0.6	-1.3
Degree of sensitization distance	0.9	1.0	1.9	1.4	-0.0
Degree of sensitization stereotypy	1.2	1.3	2.6	0.0	-1.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.4	-0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.3	1.2	-0.3
Condit. Reinf. active responses	1.6	2.0	3.0	1.0	-1.7
Condit. Reinf. inactive responses	1.5	1.8	3.5	0.3	-1.9
Incentive salience index mean	0.2	0.3	0.6	0.2	-0.7
Condit. Reinf. lever presses	0.2	0.3	0.3	-0.5	-0.5
Time in familiar zone, hab. session 1	1.3	1.2	2.2	0.5	1.5
Time in novel zone, hab. session 1	2.2	2.2	4.3	-0.0	-2.1
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.5	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	1.5	-1.2	0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.7	0.2
Time in familiar zone, hab. session 2	0.8	0.8	1.5	-0.4	1.2
Time in novel zone, hab. session 2	0.7	0.7	0.9	0.6	-1.0
Total zone transitions, hab. session 2	2.7	3.4	5.4	1.2	-2.3
Total locomotion distance, hab. session 2	0.6	0.8	1.4	-0.4	-1.2
Locomotion velocity, hab. session 2	0.5	0.7	1.4	-0.1	-1.2
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.7	0.1
Novelty place preference	0.2	0.2	0.4	-0.7	0.0
Time in novel zone, NPP test	0.1	0.2	0.3	-0.5	-0.1
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	-0.1
Total locomotion distance, NPP test	1.4	2.0	2.1	-1.3	1.5
Locomotion velocity, NPP test	1.3	1.9	2.1	-1.3	1.5
Pavlov. Cond. lever latency	0.5	0.6	1.2	-0.1	1.1
Pavlov. Cond. magazine entry latency	0.7	1.0	1.6	0.5	-1.3
Pavlov. Cond. change in total contacts	1.1	1.2	2.2	-0.5	-1.5
Pavlov. Cond. index score	1.0	1.3	2.4	0.5	-1.5
Pavlov. Cond. latency score	0.7	0.9	1.8	0.2	-1.4
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.3	-0.8
Pavlov. Cond. magazine entry number	0.9	1.1	2.0	-0.5	1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	0.8	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.9	0.5	-1.7
Pavlov. Cond. response bias	0.5	0.6	1.0	0.5	-1.0
Bone: apparent density	0.6	1.1	2.1	-0.2	1.4
Bone surface	1.5	2.7	2.8	-1.6	1.7
Bone volume	1.5	2.6	3.5	-1.3	1.9
Bone: connectivity density	0.2	0.3	0.4	-0.4	0.6
Bone: cortical apparent density	1.1	1.4	1.8	1.0	-1.4
Bone: cortical area	1.0	1.5	2.2	-0.9	1.5
Bone: cortical porosity	2.0	2.2	4.4	0.1	-2.1
Bone: cortical porosity	2.4	2.6	5.1	0.1	-2.3
Bone: cortical thickness	0.2	0.4	0.7	0.0	0.8
Bone: cortical thickness	0.9	1.0	1.7	1.3	-0.5
Bone: cortical tissue density	1.3	1.6	2.2	1.0	-1.5
Bone: elastic displacement	0.1	0.1	0.2	0.5	0.1
Bone: elastic work	1.3	1.7	2.5	-0.9	1.6
Bone: endosteal estimation	1.3	2.8	2.9	-1.7	1.6
Bone: endosteal perimeter	1.3	2.6	3.5	-1.9	1.3
Bone: final force	1.4	2.3	2.5	-1.4	1.6
Bone: final moment	1.8	2.9	3.5	-1.5	1.9
Bone: marrow area	1.3	2.8	2.8	-1.7	1.7
Bone: maximum diameter	1.0	1.9	2.4	-1.2	1.5
Bone: maximum force	2.3	4.0	4.2	-1.9	2.1
Bone: maximum moment	2.7	4.7	5.3	-2.0	2.3
Bone: minimum diameter	2.7	5.1	7.2	-2.7	1.7
Bone: periosteal estimation	1.6	3.2	3.9	-1.6	2.0
Bone: periosteal perimeter	0.8	1.2	1.7	-0.9	1.3
Bone: post-yield work	2.3	3.1	5.1	-2.3	1.0
Bone: stiffness	1.3	2.0	2.0	-1.4	1.4
Bone: tissue strength	3.9	3.7	5.2	-2.3	1.5
Bone: trabecular number	1.5	2.3	2.6	-1.4	1.6
Bone: trabecular spacing	0.0	0.0	0.0	0.2	0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.1	0.4
Bone: trabecular tissue density	3.5	4.9	9.1	3.0	-0.8
Breakpoint value in progressive ratio session	1.3	1.4	2.5	-1.6	0.6
Distance traveled before self-admin	0.0	0.0	0.0	0.2	0.0
Distance traveled after self-admin	3.2	3.5	4.3	-2.1	1.7
Delta time in closed arm before/after self-admin	2.6	2.5	3.8	-1.1	1.9
Delta time in open arm before/after self-admin	0.7	0.7	0.8	0.8	-0.9
Diff in mean of infusions in LGA sessions	0.5	0.6	1.1	-0.0	-1.1
Extinction: sum of active levers before priming	2.9	3.0	4.8	-1.1	2.2
Active lever presses in extinction session 6	2.1	2.0	3.9	0.0	2.0
Delta distance traveled before/after self-admin	4.4	4.7	5.3	-2.3	2.0
Delta ambulatory time before/after self-admin	5.1	5.6	6.6	-2.6	2.1
Time in closed arm before self-admin	2.0	2.2	3.8	0.8	-2.0
Time in closed arm after self-admin	0.0	0.0	0.1	-0.3	-0.0
Time in open arm before self-admin	3.0	3.2	4.9	-1.3	2.2
Time in open arm after self-admin	0.7	0.8	1.0	-0.7	1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	0.5
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.2	0.6	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	0.2	-0.5
Time to tail flick, test, before self-admin	0.8	0.8	1.2	-1.1	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.6	0.4
Delta time to tail flick, test, before/after SA	1.1	1.0	1.9	1.4	-0.1
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	-0.2
Ambulatory time after self-admin	6.6	7.3	9.0	-3.0	2.3
Total heroin consumption	0.4	0.5	0.9	-0.9	0.2
Area under the delay curve	0.5	0.5	1.0	-1.0	-0.1
Delay disc. indifference point, 0s delay	0.8	0.9	1.8	-1.4	-0.1
Delay disc. indifference point, 16s delay	0.8	0.9	1.7	-1.3	-0.0
Delay disc. indifference point, 2s delay	1.6	1.7	2.8	-1.7	0.8
Delay disc. indifference point, 24s delay	2.3	2.2	3.4	-1.9	1.0
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	-0.4	-0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.6	0.1
Delay discount exponential model param	0.5	0.5	1.0	1.0	-0.1
Delay discount hyperbolic model param	0.5	0.5	1.0	1.0	-0.0
Fecal boli incidents, locomotor time 1	2.7	2.9	3.0	1.7	-1.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.1
Bouts of movement, locomotor time 1	1.2	1.3	2.6	-1.6	0.2
Total resting periods, locomotor time 1	0.8	0.9	1.8	-1.3	0.1
Rest time, locomotor task time 1	1.4	1.5	1.6	1.3	-1.1
Distance moved, locomotor task time 1	0.2	0.3	0.3	-0.5	0.5
Vertical activity count, locomotor time 1	2.3	2.4	3.1	-1.8	1.3
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.6	1.1	-1.6
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.0	-0.4
Rest time, locomotor task time 2	0.7	0.9	1.0	0.8	-1.0
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.0
Vertical activity count, locomotor time 2	1.3	1.4	2.0	-1.4	0.9
Weight adjusted by age	0.2	0.2	0.4	-0.2	0.6
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	3.6	-1.9	0.7
Locomotion in novel chamber	0.5	0.6	0.7	0.9	-0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.2	-0.3
Progressive ratio	0.1	0.1	0.2	-0.1	-0.4
Food seeking constrained by brief footshock	2.0	2.5	3.0	-1.7	1.4
Seeking ratio, punishment vs. effort	0.6	0.7	1.0	-1.0	0.7
Run reversals in cocaine runway, females	1.1	1.1	1.3	-1.1	0.9
Run reversals in cocaine runway, males	1.5	1.5	2.9	1.7	0.2
Latency to leave start box in cocaine runway	0.6	0.6	1.0	-1.0	0.5
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	-0.8	0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	0.5
Cd content in liver	0.1	0.2	0.3	0.1	0.6
Co content in liver	0.3	0.4	0.4	0.7	-0.5
Cu content in liver	0.5	0.6	0.7	-0.8	0.8
Fe content in liver	0.0	0.0	0.1	0.1	-0.3
K content in liver	0.1	0.1	0.2	-0.2	-0.4
Mg content in liver	0.9	0.9	1.1	0.9	-1.0
Mn content in liver	1.7	2.0	2.6	1.6	-1.1
Na content in liver	1.5	1.6	2.6	-1.6	0.8
Rb content in liver	0.2	0.2	0.3	-0.4	-0.5
Se content in liver	7.0	8.4	9.3	3.1	-2.7
Sr content in liver	1.1	1.0	1.3	1.2	-0.9
Zn content in liver	0.1	0.1	0.1	0.2	-0.3