Hub : Genes

Kirrel2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000020864	0.19	0.09	1.1e-16	0.19	0.18	0.19	0.18	4.5e-17	4.1e-16	2.3e-17	9.5e-17
2	Brain	mRNA stability	ENSRNOG00000020864	0.25	0.11	0.0e+00	0.22	0.22	0.21	0.22	5.4e-20	3.9e-20	2.8e-19	2.5e-20
3	IL	gene expression	ENSRNOG00000020864	0.43	0.22	2.2e-03	0.13	0.03	0.03	0.04	4.9e-04	5.9e-02	5.6e-02	3.4e-02
4	LHb	gene expression	ENSRNOG00000020864	0.31	0.15	1.2e-04	0.2	0.19	0.18	0.2	1.3e-05	3.0e-05	3.9e-05	2.2e-05
5	PL	gene expression	ENSRNOG00000020864	0.06	0.05	2.4e-03	0.01	0.04	0.02	0.02	2.4e-02	1.0e-03	8.5e-03	5.9e-03
6	PL	mRNA stability	ENSRNOG00000020864	0.26	0.13	2.7e-07	0.1	0.07	0.04	0.09	8.4e-08	7.2e-06	2.3e-04	4.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	0.2	0.7	1.0	-0.9	0.9	-0.5	-0.9	-0.8	1.0
BMI without tail	0.0	0.0	0.1	0.2	-0.3	0.1	0.3	0.2	-0.2
Body weight	2.0	8.5	12.1	3.1	-2.8	2.4	2.8	3.5	-2.9
Epididymis fat weight	0.0	0.0	0.1	0.2	-0.0	-0.3	0.0	0.4	-0.2
Glucose	0.3	0.4	0.6	0.5	-0.8	0.3	0.8	0.4	-0.8
Heart weight	0.2	0.3	0.5	-0.5	0.7	-0.3	-0.7	-0.1	0.7
Left kidney weight	4.3	12.5	14.2	3.6	-3.4	3.4	3.4	3.8	-3.6
Right kidney weight	5.8	16.6	19.5	4.3	-4.0	3.6	3.9	4.4	-4.1
Tail length	3.7	11.2	14.3	3.6	-3.4	2.4	3.3	3.8	-3.5
Length with tail	4.9	18.0	26.2	4.5	-4.1	3.2	4.0	5.1	-4.3
Length without tail	2.6	5.8	10.2	2.4	-2.2	2.0	2.1	3.2	-2.3
Liver weight, left	0.2	0.3	0.5	0.3	-0.7	0.7	0.7	0.2	-0.6
Liver weight, right	0.1	0.2	0.4	0.1	-0.6	-0.3	0.7	-0.0	-0.5
Parametrial fat weight	3.0	5.9	7.2	2.2	-2.6	2.7	2.7	1.7	-2.5
Retroperitoneal fat weight	0.1	0.2	0.3	0.0	-0.5	0.3	0.5	-0.4	-0.6
Intraocular pressure	0.2	0.3	0.6	-0.4	0.8	-0.2	-0.8	-0.5	0.5
Extensor digitorum longus weight	0.4	1.7	5.3	1.2	-0.9	2.3	0.9	0.8	-1.2
Soleus weight	0.0	0.1	0.1	0.1	-0.2	0.4	0.2	-0.0	-0.3
Tibialis anterior weight	0.9	3.0	5.2	1.6	-1.6	2.3	1.6	1.4	-1.7
Tibia length	1.7	4.8	7.6	2.4	-1.9	2.0	1.9	2.7	-1.9
Number of licking bursts	4.4	5.2	5.8	-2.3	2.2	-2.4	-2.2	-2.2	2.2
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.3	0.5	-0.7	-0.5	-0.1	0.5
Times rat made contact with spout	0.6	0.7	0.9	0.8	-0.9	0.9	0.9	0.5	-0.9
Mean time between licks in bursts	0.3	0.3	0.4	-0.5	0.7	-0.5	-0.7	-0.6	0.7
Mean num. licks in bursts	4.7	5.7	6.5	2.4	-2.4	2.6	2.4	2.2	-2.4
Std. dev. time between licks in bursts	2.4	2.8	3.9	-1.5	1.7	-2.0	-1.7	-1.4	1.7
Water consumed over 24 hours	0.4	0.4	0.6	0.8	-0.5	0.6	0.5	0.7	-0.6
Indifference point 0 sec	0.1	0.2	0.3	-0.5	0.2	-0.6	-0.2	-0.2	0.4
Indifference point AUC	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.1	-0.4	-0.0
Indifference point function ln k	0.2	0.2	0.5	0.7	-0.4	0.4	0.4	0.5	-0.5
Indifference point function log k	0.2	0.2	0.5	0.7	-0.4	0.4	0.4	0.5	-0.5
Delay discounting total patch changes 0 sec	0.1	0.1	0.4	-0.4	0.2	-0.6	-0.2	-0.1	0.3
Delay discounting total patch changes 12 sec	0.0	0.1	0.2	-0.3	-0.0	-0.4	0.1	-0.3	-0.1
Delay discounting total patch changes 18 sec	0.4	0.5	0.9	-0.8	0.6	-0.9	-0.6	-0.4	0.7
Delay discounting total patch changes 24 sec	0.0	0.1	0.2	-0.2	0.2	-0.3	-0.2	0.4	0.2
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.1	-0.1	0.0
Delay discounting time to switch 0 sec	0.0	0.1	0.3	-0.2	0.0	-0.0	-0.0	-0.6	0.1
Delay discounting water rate 0 sec	0.6	1.0	1.2	-1.0	1.0	-1.0	-1.0	-1.1	0.9
Delay discounting water rate 12 sec	0.1	0.2	0.9	0.0	-0.1	-0.9	0.1	0.5	-0.0
Delay discounting water rate 18 sec	0.1	0.2	0.5	-0.4	0.3	-0.7	-0.3	-0.5	0.3
Delay discounting water rate 24 sec	2.2	3.0	4.2	-1.4	1.9	-2.0	-1.9	-1.1	1.7
Delay discounting water rate 6 sec	0.2	0.2	0.8	-0.3	0.5	-0.9	-0.5	0.3	0.3
Locomotor activity	0.5	0.8	1.5	0.7	-1.2	0.4	1.2	0.2	-1.2
Locomotor testing distance	0.2	0.4	0.7	0.5	-0.8	-0.1	0.9	0.1	-0.8
Locomotor testing rearing	0.2	0.4	1.1	-0.5	0.3	-1.0	-0.3	-0.8	0.3
Light reinforcement 1	0.6	1.1	2.2	-1.1	0.8	-1.5	-0.8	-0.8	1.0
Light reinforcement 2	1.3	1.7	2.9	-1.4	1.3	-0.9	-1.2	-1.7	1.3
Reaction time number correct	0.1	0.2	0.3	0.5	-0.3	0.5	0.3	0.3	-0.4
Reaction time mean minus median	0.4	0.5	0.9	0.7	-0.7	0.6	0.7	0.9	-0.8
Reaction time mean minus median AUC	1.2	1.6	2.3	1.2	-1.2	1.2	1.1	1.5	-1.3
Reaction time num false alarms	0.4	0.6	0.7	-0.8	0.8	-0.6	-0.8	-0.9	0.8
Reaction time num false alarms AUC	0.5	0.7	1.0	-0.9	0.9	-0.6	-0.9	-1.0	0.8
Reaction time trials correct on left	0.1	0.2	0.3	0.5	-0.3	0.5	0.3	0.3	-0.4
Reaction time trials on left	0.1	0.2	0.3	0.6	-0.4	0.5	0.4	0.4	-0.4
Reaction time mean	0.1	0.1	0.5	0.3	-0.3	0.0	0.3	0.7	-0.3
Reaction time mean AUC	0.1	0.1	0.3	0.3	-0.3	-0.0	0.3	0.6	-0.4
Median of all reaction times	0.0	0.0	0.1	0.0	-0.0	-0.3	0.0	0.3	-0.0
Reaction time omissions	0.2	0.3	0.5	0.4	-0.6	0.7	0.6	0.5	-0.6
Reaction time false alarm rate	0.6	0.9	1.1	-1.0	0.9	-0.8	-0.9	-1.0	0.9
Reaction time premature initiation rate	1.1	1.4	3.0	-1.0	1.1	-1.7	-1.1	-0.9	1.1
Reaction time premature initiations	0.6	0.9	2.0	-0.7	0.9	-1.4	-0.9	-0.7	0.9
Std. dev. reaction times	0.3	0.4	1.1	0.5	-0.5	0.4	0.4	1.0	-0.6
Reaction time trials completed	0.1	0.2	0.3	0.6	-0.4	0.5	0.4	0.4	-0.4
Reaction time trials AUC	0.3	0.4	0.6	0.8	-0.6	0.8	0.6	0.5	-0.6
Social response proportion	0.5	0.5	1.5	0.7	-0.2	1.2	0.2	0.7	-0.6
Social responses	0.0	0.1	0.2	0.0	0.0	0.5	-0.0	0.1	-0.3
Social time	0.2	0.3	1.1	0.5	-0.2	0.4	0.2	1.0	-0.4
Conditioned locomotion	0.9	1.1	1.4	-1.0	1.1	-0.6	-1.1	-1.2	1.1
Cocaine response after cond. corrected	0.8	0.9	1.4	0.7	-1.0	1.2	1.0	0.5	-1.0
Cocaine response after cond. not corrected	1.8	2.0	2.8	1.1	-1.6	1.4	1.7	0.9	-1.6
Cocaine response before conditioning	0.9	1.1	1.5	0.9	-1.2	0.1	1.2	1.2	-1.1
Saline control response	0.2	0.3	0.4	0.6	-0.6	0.5	0.6	0.3	-0.6
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.4	-0.7	0.4	0.7	0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.3	-0.0	0.1	0.0	-0.1	0.1
Condit. Reinf. active responses	0.6	0.9	1.8	0.8	-1.0	0.4	0.9	1.3	-0.8
Condit. Reinf. inactive responses	0.2	0.2	0.9	0.4	-0.3	-0.4	0.3	0.9	-0.3
Condit. Reinf. lever presses	3.6	4.9	6.8	2.2	-2.2	1.9	2.2	2.6	-2.1
Condit. Reinf. lever reinforcers received	0.4	0.6	1.5	0.6	-0.7	0.2	0.7	1.2	-0.6
Pavlov. Cond. lever latency	1.3	1.8	3.4	-1.3	1.3	-1.0	-1.3	-1.9	1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	0.8	-0.8	0.4	0.8	1.0	-0.7
Pavlov. Cond. change in total contacts	1.4	2.0	4.8	1.4	-1.2	1.0	1.2	2.2	-1.2
Pavlov. Cond. index score	1.2	1.6	3.1	1.3	-1.2	0.7	1.2	1.8	-1.1
Pavlov. Cond. latency score	1.0	1.2	2.5	1.1	-1.1	0.6	1.0	1.6	-1.0
Pavlov. Cond. lever contacts	1.0	1.4	3.1	1.2	-1.1	0.8	1.1	1.7	-1.0
Pavlov. Cond. magazine entry number	1.5	1.8	3.1	-1.4	1.3	-0.9	-1.3	-1.8	1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	0.5	-0.0	-0.5	-0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.5	1.4	-1.4	0.9	1.4	1.9	-1.3
Pavlov. Cond. response bias	1.0	1.3	3.2	1.2	-1.1	0.7	1.0	1.8	-0.9
Conditioned reinforcement - actives	0.3	0.3	1.3	-0.5	0.2	-1.2	-0.2	-0.5	0.3
Conditioned reinforcement - inactives	2.8	3.1	4.5	-1.5	1.9	-2.1	-1.9	-1.1	1.9
Conditioned locomotion	4.2	5.1	5.9	-2.2	2.1	-2.4	-2.1	-2.3	2.3
Intermittent access intake day 1-15 change	1.5	1.5	2.6	1.3	-1.0	1.2	1.0	1.6	-1.1
Intermittent access intake escalation	1.1	1.1	2.1	1.1	-0.8	1.1	0.7	1.5	-0.9
Intermittent access intake escalation 2	1.3	1.3	1.7	1.1	-1.1	1.1	1.1	1.3	-1.1
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.3	1.0	-0.6	1.1	0.6	1.1	-0.7
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.1	-0.6	1.0	-0.4	-1.1	-0.4	1.0
Intermitt. access escalation Index	1.0	0.9	1.4	-0.9	0.9	-0.9	-0.9	-0.7	1.2
Intermittent access day 1 total infusions	6.4	7.2	9.7	-2.7	2.6	-3.1	-2.6	-2.5	2.6
Intermittent access day 15 total infusions	3.0	3.3	4.7	-1.7	1.9	-2.2	-1.9	-1.3	1.9
Intermittent access terminal intake (last 3 days)	4.1	4.4	6.4	-2.1	2.1	-2.5	-2.1	-1.7	2.1
Intermittent access total infusions	4.6	5.1	8.0	-2.2	2.2	-2.8	-2.2	-1.9	2.2
Intermittent access day 1 locomotion	6.8	7.0	8.9	-2.5	2.7	-3.0	-2.7	-2.3	2.5
Intermittent access day 15 total locomotion	3.0	3.2	4.3	-1.6	1.9	-2.1	-2.0	-1.2	1.7
Intermittent access total locomotion	4.6	5.2	7.0	-2.2	2.3	-2.7	-2.3	-2.1	2.1
Intermittent access standard deviation	0.3	0.4	1.5	0.4	-0.4	0.2	0.4	1.2	-0.3
Cocaine induced anxiety	0.6	0.7	1.5	0.8	-0.7	1.2	0.7	0.7	-0.6
Post-drug Anxiety	0.1	0.1	0.5	0.1	-0.0	0.7	0.0	-0.2	0.1
Baseline Anxiety	1.9	2.0	2.4	-1.6	1.3	-1.4	-1.3	-1.4	1.4
Lifetime Intake	2.8	3.2	5.2	-1.8	1.6	-2.3	-1.7	-1.5	1.7
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.4	0.6	-0.8	-0.7	-0.5	0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	-0.3	0.5	-0.7	-0.6	-0.4	0.5
Progressive ratio test 1 active lever presses	1.2	1.3	2.6	-1.1	1.1	-1.6	-1.1	-0.5	1.1
Progressive ratio test 1 breakpoint	0.5	0.6	1.4	-0.7	0.7	-1.2	-0.7	-0.2	0.7
Progressive ratio test 1 inactive lever presses	2.0	2.2	2.5	-1.5	1.6	-1.6	-1.6	-0.9	1.6
Progressive ratio test 2 active lever presses	1.5	1.6	3.3	-1.1	1.2	-1.8	-1.2	-0.8	1.2
Progressive ratio test 2 breakpoint	1.3	1.4	3.2	-1.0	1.1	-1.8	-1.1	-0.8	1.1
Progressive ratio test 2 inactive lever presses	3.9	4.5	6.3	-1.6	2.5	-2.0	-2.5	-1.5	2.4
Total sessions with >9 infusions	0.7	0.8	1.7	-1.0	0.6	-1.3	-0.6	-0.9	0.6
Short access day 1 total inactive lever presses	3.6	4.0	5.0	-1.7	2.2	-2.0	-2.2	-1.5	2.2
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.2	0.2	0.4	-0.2	0.2	0.3
Short access day 1 total infusions	0.4	0.4	0.8	-0.7	0.5	-0.9	-0.5	-0.5	0.6
Short access day 10 total infusions	0.7	0.7	1.1	-1.0	0.7	-1.1	-0.7	-0.8	0.9
Short access total infusions	0.6	0.6	1.2	-0.9	0.5	-1.1	-0.5	-0.8	0.6
Short access day 1 locomotion	0.3	0.3	0.5	-0.6	0.5	-0.7	-0.5	-0.5	0.6
Short access day 10 total locomotion	0.9	1.0	2.4	-0.9	0.9	-1.6	-1.0	-0.6	0.9
Short access total locomotion	1.6	1.7	2.6	-1.3	1.1	-1.6	-1.1	-1.3	1.1
Compulsive drug intake	0.0	0.0	0.1	-0.3	-0.2	0.0	0.2	0.2	-0.1
One hour access (0.3 mA shock)	1.3	1.6	4.9	-1.1	1.0	-2.2	-1.0	-0.5	1.0
One hour access (shock baseline)	1.5	1.8	4.0	-1.0	1.3	-2.0	-1.3	-1.0	1.1
Number of responses in last shaping day	2.5	2.5	4.0	-1.5	1.5	-2.0	-1.6	-1.3	1.6
Context. condit. distance diff. score	0.5	0.6	0.9	-0.8	0.9	-0.4	-0.9	-0.5	1.0
Locomotion velocity, session 1	0.2	0.2	0.3	0.4	-0.6	0.0	0.6	0.0	-0.5
Locomotion distance, session 1	0.0	0.0	0.1	0.2	0.0	-0.3	-0.1	0.3	0.0
Locomotion velocity, session 2	0.4	0.5	1.5	-0.7	0.3	-1.2	-0.3	-0.9	0.4
Locomotion distance, session 2	2.3	3.3	5.1	-1.7	1.8	-2.2	-1.8	-1.8	1.5
Locomotion velocity, session 3	0.3	0.3	0.9	-0.7	0.3	-0.9	-0.3	-0.5	0.3
Locomotion distance, session 3	0.4	0.5	1.0	-0.7	0.7	-1.0	-0.7	0.2	0.7
Stereotopy head waving bouts, day 3	0.5	0.6	0.8	0.7	-0.8	0.9	0.9	0.1	-0.8
Stereotopy head waving duration, day 3	0.3	0.4	0.8	0.5	-0.5	0.9	0.6	-0.3	-0.7
Locomotion velocity, session 7	0.2	0.2	0.3	-0.4	0.4	-0.6	-0.5	-0.0	0.5
Locomotion distance, session 7	0.1	0.1	0.2	0.3	-0.3	-0.2	0.3	0.4	-0.4
Stereotopy head waving bouts, day 7	2.3	2.6	3.2	-1.6	1.5	-1.8	-1.5	-1.6	1.6
Stereotopy head waving duration, day 7	1.6	2.0	2.7	-1.4	1.4	-1.2	-1.3	-1.7	1.5
Locomotion velocity, session 8	4.4	5.3	6.2	-2.5	2.2	-2.2	-2.2	-2.4	2.3
Locomotion distance, session 8	2.8	4.1	4.7	-2.1	2.1	-2.2	-2.1	-1.8	1.9
Degree of sensitization distance	0.6	0.6	0.9	0.9	-0.8	0.7	0.9	0.4	-1.0
Degree of sensitization stereotypy	3.5	3.9	4.8	-2.0	1.9	-2.2	-1.9	-1.8	2.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.6	-0.2	-0.6	-0.5	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.2	0.4	-0.3	1.1	0.4	0.1	-0.6
Condit. Reinf. active responses	2.2	2.7	3.4	-1.8	1.7	-1.2	-1.7	-1.8	1.6
Condit. Reinf. inactive responses	4.6	5.4	6.2	-2.5	2.2	-2.3	-2.2	-2.3	2.5
Incentive salience index mean	0.5	0.6	0.8	-0.9	0.9	-0.6	-0.9	-0.8	0.7
Condit. Reinf. lever presses	0.7	0.9	1.2	-1.1	1.0	-1.0	-1.0	-0.8	0.9
Time in familiar zone, hab. session 1	3.9	3.7	5.8	2.0	-1.8	2.4	1.8	1.6	-1.9
Time in novel zone, hab. session 1	4.9	4.8	6.5	-2.3	2.1	-2.5	-2.1	-2.1	1.9
Total zone transitions, hab. session 1	0.4	0.5	0.9	-0.7	0.7	-0.9	-0.7	-0.5	0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.7	0.1	-0.2	-0.8	0.2	0.2	-0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.3	0.3	-0.4	-0.5	0.4	0.3	-0.4
Time in familiar zone, hab. session 2	2.6	2.7	4.2	1.7	-1.5	2.1	1.5	1.4	-1.7
Time in novel zone, hab. session 2	1.1	1.1	2.2	-1.1	0.8	-1.5	-0.8	-1.0	1.0
Total zone transitions, hab. session 2	2.8	3.7	4.9	-1.9	1.9	-2.1	-1.9	-2.2	1.5
Total locomotion distance, hab. session 2	1.3	1.8	2.8	-1.2	1.3	-1.7	-1.3	-1.3	1.0
Locomotion velocity, hab. session 2	1.0	1.3	2.2	-1.0	1.2	-1.5	-1.2	-1.2	0.9
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.2	0.0	0.4
Novelty place preference	0.2	0.2	0.3	-0.6	0.3	-0.5	-0.3	-0.1	0.5
Time in novel zone, NPP test	0.3	0.3	0.5	-0.7	0.5	-0.6	-0.5	-0.3	0.7
Total zone transitions, NPP test	0.0	0.0	0.2	-0.2	0.1	-0.4	-0.1	-0.2	-0.0
Total locomotion distance, NPP test	1.1	1.6	2.1	1.3	-1.4	0.4	1.3	1.5	-1.4
Locomotion velocity, NPP test	1.3	1.8	2.3	1.4	-1.4	0.6	1.4	1.5	-1.5
Pavlov. Cond. lever latency	0.9	1.1	2.6	1.1	-0.8	1.6	0.8	1.0	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	3.0	-0.6	0.2	-1.7	-0.2	-0.8	0.0
Pavlov. Cond. change in total contacts	2.9	3.1	6.4	-1.9	1.4	-2.5	-1.4	-1.5	1.4
Pavlov. Cond. index score	0.9	1.2	3.8	-1.1	0.6	-1.9	-0.6	-1.1	0.5
Pavlov. Cond. latency score	1.0	1.3	3.7	-1.1	0.7	-1.9	-0.7	-1.1	0.6
Pavlov. Cond. lever contacts	0.5	0.6	1.7	-0.9	0.5	-1.3	-0.5	-0.7	0.6
Pavlov. Cond. magazine entry number	0.8	1.0	3.9	0.8	-0.5	2.0	0.5	1.0	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.6	0.5	-0.1	-0.5	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	4.6	-1.2	0.8	-2.2	-0.8	-1.3	0.7
Pavlov. Cond. response bias	0.3	0.3	1.5	-0.4	-0.1	-1.2	0.1	-0.5	-0.2
Bone: apparent density	1.6	2.7	2.9	1.6	-1.7	1.7	1.7	1.7	-1.5
Bone surface	0.6	1.1	2.0	1.2	-1.0	0.8	1.0	1.4	-0.8
Bone volume	1.2	2.0	3.0	1.5	-1.4	1.2	1.4	1.7	-1.2
Bone: connectivity density	0.3	0.4	0.5	0.6	-0.7	0.5	0.7	0.7	-0.6
Bone: cortical apparent density	1.3	1.7	2.1	-1.4	1.3	-1.1	-1.3	-1.4	1.3
Bone: cortical area	1.1	1.7	2.2	1.3	-1.3	1.1	1.3	1.5	-1.4
Bone: cortical porosity	5.2	5.6	8.5	-2.5	2.2	-2.9	-2.2	-2.2	2.2
Bone: cortical porosity	6.3	6.8	10.2	-2.7	2.4	-3.2	-2.4	-2.4	2.4
Bone: cortical thickness	0.7	1.1	1.4	1.0	-1.1	0.9	1.1	1.0	-1.2
Bone: cortical thickness	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	-0.3	-0.2
Bone: cortical tissue density	1.6	2.1	2.5	-1.5	1.4	-1.2	-1.4	-1.6	1.5
Bone: elastic displacement	0.3	0.3	0.7	0.5	-0.7	0.1	0.7	0.4	-0.8
Bone: elastic work	1.5	1.9	2.4	1.6	-1.3	1.0	1.3	1.5	-1.5
Bone: endosteal estimation	0.6	1.3	2.1	1.3	-1.1	0.8	1.0	1.5	-1.0
Bone: endosteal perimeter	0.2	0.4	1.1	0.8	-0.5	0.3	0.5	1.0	-0.5
Bone: final force	0.6	1.0	1.7	1.1	-0.9	1.1	0.8	1.3	-0.8
Bone: final moment	1.0	1.6	2.6	1.3	-1.1	1.2	1.1	1.6	-1.1
Bone: marrow area	0.7	1.4	2.3	1.3	-1.1	0.9	1.1	1.5	-1.1
Bone: maximum diameter	0.7	1.4	2.1	1.2	-1.0	1.1	1.0	1.4	-1.1
Bone: maximum force	1.0	1.7	2.9	1.4	-1.1	1.3	1.1	1.7	-1.1
Bone: maximum moment	1.3	2.2	3.7	1.6	-1.3	1.4	1.3	1.9	-1.3
Bone: minimum diameter	0.3	0.5	1.5	0.7	-0.5	0.1	0.5	1.2	-0.5
Bone: periosteal estimation	1.2	2.4	3.4	1.6	-1.5	1.2	1.5	1.9	-1.5
Bone: periosteal perimeter	0.9	1.4	1.7	1.3	-1.2	0.9	1.2	1.3	-1.3
Bone: post-yield work	0.1	0.1	0.2	-0.1	0.3	-0.0	-0.4	0.4	0.4
Bone: stiffness	0.5	0.8	1.8	0.9	-0.6	1.4	0.6	1.1	-0.5
Bone: tissue strength	0.2	0.2	0.8	0.3	-0.1	0.3	0.1	0.9	-0.0
Bone: trabecular number	0.8	1.3	2.0	1.2	-1.0	1.1	1.0	1.4	-0.8
Bone: trabecular spacing	0.2	0.3	0.5	0.4	-0.7	0.1	0.7	0.4	-0.7
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.2	0.3	0.2	0.4	-0.1
Bone: trabecular tissue density	0.5	0.7	1.1	0.6	-1.0	0.8	1.1	0.0	-1.0
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.1	0.6	-0.0	-0.6	-0.1	0.1
Distance traveled before self-admin	0.0	0.0	0.1	0.2	-0.3	-0.2	0.3	-0.1	-0.1
Distance traveled after self-admin	0.9	0.9	1.8	1.0	-0.9	0.3	0.9	1.4	-1.0
Delta time in closed arm before/after self-admin	2.8	2.7	3.7	1.7	-1.4	1.9	1.4	1.8	-1.5
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.8	0.1	-0.8	-0.1	-0.5	0.5
Diff in mean of infusions in LGA sessions	1.7	1.9	2.7	-1.1	1.6	-0.9	-1.6	-1.5	1.3
Extinction: sum of active levers before priming	3.7	3.7	4.3	2.1	-1.7	2.1	1.7	2.0	-2.0
Active lever presses in extinction session 6	6.6	6.3	6.8	2.5	-2.6	2.5	2.6	2.3	-2.6
Delta distance traveled before/after self-admin	1.2	1.3	3.0	1.1	-0.9	1.0	0.9	1.7	-1.0
Delta ambulatory time before/after self-admin	1.2	1.4	3.4	1.1	-0.9	0.9	0.9	1.8	-1.1
Time in closed arm before self-admin	3.8	4.4	5.5	-2.3	1.9	-2.2	-1.9	-2.1	2.0
Time in closed arm after self-admin	0.2	0.2	0.3	-0.3	0.5	-0.0	-0.5	-0.4	0.5
Time in open arm before self-admin	4.9	5.2	6.0	2.4	-2.2	2.0	2.2	2.3	-2.5
Time in open arm after self-admin	1.3	1.4	2.0	0.9	-1.4	0.4	1.4	1.4	-1.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.6	-0.2	0.6	0.2	0.3	-0.4
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.2	-1.0	0.8	-1.0	-0.8	-1.1	1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.2	0.0	-0.5	-0.0	-0.4	0.3
Time to tail flick, test, before self-admin	2.9	2.9	3.8	-1.7	1.7	-1.9	-1.7	-1.1	2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.3	-0.5	-0.3	-0.1	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.3	-0.4	-0.0	0.4	0.5	-0.3
Delta time to tail flick, test, before/after SA	1.1	1.0	1.4	1.0	-1.2	0.9	1.2	0.5	-1.2
Ambulatory time before self-admin	0.0	0.0	0.1	-0.0	0.0	-0.3	-0.0	-0.3	0.0
Ambulatory time after self-admin	1.2	1.4	3.0	1.2	-1.0	0.7	0.9	1.7	-1.1
Total heroin consumption	0.2	0.2	0.4	-0.0	0.6	-0.5	-0.6	-0.3	0.4
Area under the delay curve	0.5	0.5	0.9	-0.6	0.9	-0.5	-0.9	-0.5	0.6
Delay disc. indifference point, 0s delay	1.9	2.1	3.0	-1.2	1.7	-1.0	-1.7	-1.0	1.7
Delay disc. indifference point, 16s delay	0.6	0.6	0.9	-0.7	0.9	-0.6	-0.9	-0.5	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.1	0.5	-0.3	-0.5	0.2	0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	0.2	0.2	-0.2	0.5	-0.1
Delay disc. indifference point, 4s delay	1.3	1.4	2.3	-1.1	1.2	-1.5	-1.2	-1.0	1.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2	0.0	-0.0
Delay discount exponential model param	0.2	0.2	0.5	0.4	-0.7	0.4	0.7	0.3	-0.3
Delay discount hyperbolic model param	0.3	0.3	0.6	0.5	-0.8	0.5	0.8	0.3	-0.4
Fecal boli incidents, locomotor time 1	0.8	0.9	2.1	-0.9	0.9	-0.7	-0.9	-1.5	0.7
Change in fecal boli incidents, locomotor task	1.4	1.3	2.0	1.1	-1.1	1.4	1.1	0.9	-1.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	0.0	0.2	-0.0	-0.0	0.3
Bouts of movement, locomotor time 1	0.6	0.7	1.3	-0.7	0.9	-1.1	-0.9	-0.5	0.7
Total resting periods, locomotor time 1	0.5	0.6	1.1	-0.5	0.8	-1.1	-0.8	-0.5	0.6
Rest time, locomotor task time 1	0.5	0.6	1.3	-0.5	0.8	-0.2	-0.8	-1.1	0.7
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.3	-0.1	0.0	0.1	0.4	-0.3
Vertical activity count, locomotor time 1	0.6	0.6	1.3	0.7	-0.7	0.2	0.7	1.1	-0.9
Time >=10cm from walls, locomotor time 2	1.6	1.7	2.5	-1.3	1.3	-1.3	-1.3	-1.6	1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.3	0.1	-0.7	-0.1	-0.2	0.1
Total resting periods, locomotor time 2	0.1	0.1	0.6	-0.4	0.1	-0.7	-0.1	-0.3	0.1
Rest time, locomotor task time 2	0.3	0.3	0.7	-0.4	0.5	-0.6	-0.5	-0.8	0.4
Distance moved, locomotor task time 2	0.2	0.2	0.4	-0.4	0.5	-0.6	-0.5	-0.2	0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.2	-0.1	-0.1	0.1	0.5	-0.3
Weight adjusted by age	0.4	0.4	0.6	0.7	-0.5	0.7	0.5	0.7	-0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	-0.2	0.6	-0.7	-0.7	0.2	0.6
Locomotion in novel chamber	0.1	0.1	0.3	-0.1	0.1	0.3	-0.1	-0.5	-0.0
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.1	0.0	0.2	-0.0	-0.3	-0.1
Progressive ratio	0.2	0.2	0.7	-0.6	0.2	-0.8	-0.2	-0.3	0.4
Food seeking constrained by brief footshock	0.7	0.8	1.6	0.7	-1.0	0.3	1.0	1.3	-0.8
Seeking ratio, punishment vs. effort	0.0	0.0	0.2	0.2	-0.1	0.1	0.1	0.4	-0.1
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.3	-0.1	0.3	0.0	0.7	-0.3
Run reversals in cocaine runway, males	2.9	2.8	3.8	1.2	-1.9	1.9	1.9	1.1	-1.7
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.3	0.6	-0.3	-0.6	0.0	0.6
Latency to leave start box in cocaine runway, F	0.4	0.5	0.8	-0.7	0.9	-0.3	-0.9	-0.3	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.3	0.1	0.3	0.4	-0.1
Cd content in liver	0.3	0.3	0.4	0.6	-0.6	0.2	0.6	0.6	-0.6
Co content in liver	0.1	0.1	0.2	-0.3	0.3	0.3	-0.3	-0.4	0.3
Cu content in liver	0.2	0.2	0.4	0.5	-0.3	0.5	0.3	0.6	-0.2
Fe content in liver	0.1	0.1	0.2	-0.5	0.4	-0.2	-0.4	-0.3	0.4
K content in liver	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.3	-0.3	0.3
Mg content in liver	0.2	0.2	0.5	-0.5	0.4	-0.2	-0.4	-0.7	0.4
Mn content in liver	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.1	-0.6	-0.1
Na content in liver	0.1	0.1	0.3	0.1	0.0	-0.6	-0.0	0.5	-0.0
Rb content in liver	0.9	1.2	1.8	-1.1	1.3	-0.1	-1.3	-0.9	1.3
Se content in liver	2.1	2.6	5.3	-1.7	1.5	-1.0	-1.4	-2.3	1.5
Sr content in liver	0.1	0.1	0.2	-0.3	-0.0	-0.3	0.0	-0.5	-0.0
Zn content in liver	0.1	0.1	0.2	-0.4	0.4	0.2	-0.4	-0.3	0.4