Hub : Genes

Tbcb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000020781 0.04 0.04 8.3e-03 0.01 0.01 0.01 0.01 8.6e-03 4.5e-02 1.4e-02 2.6e-02
2 Adipose mRNA stability ENSRNOG00000020781 0.05 0.04 7.1e-06 0.02 0.03 0.03 0.03 1.2e-03 3.6e-04 5.3e-04 7.2e-04
3 BLA gene expression ENSRNOG00000020781 0.19 0.09 6.4e-09 0.1 0.14 0.14 0.13 3.9e-06 3.5e-08 8.9e-08 1.4e-07
4 BLA mRNA stability ENSRNOG00000020781 0.29 0.12 1.0e-14 0.25 0.26 0.27 0.27 1.9e-13 2.3e-14 5.4e-15 7.2e-15
5 Brain gene expression ENSRNOG00000020781 0.09 0.06 7.3e-08 0.07 0.06 0.06 0.07 3.6e-07 4.9e-06 1.1e-06 5.6e-07
6 Brain mRNA stability ENSRNOG00000020781 0.52 0.07 0.0e+00 0.58 0.26 0.6 0.21 2.2e-66 5.2e-24 4.0e-69 3.0e-19
7 IL mRNA stability ENSRNOG00000020781 0.37 0.19 8.4e-07 0.24 0.02 0.13 0.2 2.1e-06 9.5e-02 4.2e-04 1.5e-05
8 LHb gene expression ENSRNOG00000020781 0.71 0.22 2.6e-03 0.12 -0.01 0.1 0 1.0e-03 5.7e-01 2.1e-03 2.4e-01
9 LHb mRNA stability ENSRNOG00000020781 0.41 0.16 2.5e-10 0.3 0.12 0.32 0.25 5.6e-08 7.5e-04 1.8e-08 1.2e-06
10 Liver mRNA stability ENSRNOG00000020781 0.06 0.04 1.1e-07 0.05 0.05 0.05 0.05 1.6e-06 1.9e-06 3.6e-06 2.6e-06
11 NAcc gene expression ENSRNOG00000020781 0.28 0.14 8.8e-10 0.14 0.14 0.13 0.13 2.3e-10 1.5e-10 1.3e-09 3.6e-10
12 NAcc mRNA stability ENSRNOG00000020781 0.31 0.13 0.0e+00 0.31 0.31 0.31 0.31 1.7e-23 1.0e-23 1.3e-23 1.4e-23
13 OFC mRNA stability ENSRNOG00000020781 0.37 0.17 1.7e-07 0.21 0.06 0.2 0.23 1.2e-05 1.3e-02 1.4e-05 3.7e-06
14 PL gene expression ENSRNOG00000020781 0.16 0.1 1.0e-10 0.13 0.12 0.11 0.12 2.3e-10 1.4e-09 1.0e-08 1.0e-09
15 PL mRNA stability ENSRNOG00000020781 0.32 0.13 0.0e+00 0.36 0.4 0.4 0.4 6.4e-29 1.5e-32 3.9e-32 9.5e-33

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
BMI with tail0.20.71.2-0.31.0-0.60.7-0.80.90.8-0.81.00.6-0.70.91.1-0.90.9
BMI without tail0.10.10.2-0.4-0.30.1-0.40.4-0.5-0.40.3-0.3-0.40.3-0.3-0.10.3-0.4
Body weight2.510.513.21.5-3.42.8-3.43.3-3.3-3.33.3-3.2-3.53.6-3.3-3.53.3-3.3
Epididymis fat weight0.10.20.50.5-0.30.5-0.50.3-0.3-0.30.5-0.3-0.60.7-0.4-0.30.5-0.3
Glucose0.20.30.8-0.90.2-0.90.6-0.60.40.6-0.30.40.1-0.50.50.3-0.40.5
Heart weight0.20.31.21.1-0.30.9-0.40.3-0.3-0.40.5-0.5-0.50.6-0.2-0.60.5-0.3
Left kidney weight2.57.110.20.3-3.01.7-2.62.9-3.0-2.92.6-2.4-3.23.1-3.0-2.62.6-2.8
Right kidney weight4.613.116.60.8-4.02.7-3.63.9-4.0-3.93.6-3.5-4.13.9-3.9-3.73.6-3.9
Tail length4.814.516.91.2-4.03.1-3.94.0-4.1-4.04.0-3.9-3.94.0-3.9-4.14.0-4.0
Length with tail7.929.135.02.8-5.64.8-5.55.5-5.5-5.65.5-5.5-5.55.8-5.5-5.95.5-5.6
Length without tail5.411.715.92.5-3.43.3-3.63.4-3.3-3.53.4-3.3-3.54.0-3.5-3.63.4-3.4
Liver weight, left0.40.72.2-1.50.6-1.40.8-0.60.50.7-0.60.80.7-0.70.60.9-0.60.6
Liver weight, right0.20.32.0-1.40.2-0.90.4-0.20.10.2-0.30.40.6-0.30.20.6-0.30.1
Parametrial fat weight0.50.99.0-3.0-0.2-1.80.5-0.1-0.30.10.00.30.3-0.2-0.20.70.00.0
Retroperitoneal fat weight1.44.88.5-2.81.8-2.92.3-2.21.92.2-1.92.22.0-2.01.92.2-2.02.1
Intraocular pressure0.10.10.30.60.20.30.1-0.30.30.2-0.30.10.5-0.20.2-0.0-0.30.2
Extensor digitorum longus weight0.20.71.8-1.30.4-1.40.8-0.80.60.9-0.70.80.6-0.70.70.5-0.70.7
Soleus weight0.10.30.6-0.70.5-0.80.5-0.50.50.5-0.50.60.6-0.40.40.7-0.50.4
Tibialis anterior weight0.10.31.7-1.3-0.1-1.10.4-0.40.20.5-0.30.40.2-0.30.3-0.0-0.30.3
Tibia length2.87.911.41.9-2.82.6-3.02.6-2.7-2.73.2-2.9-3.42.9-2.8-2.83.2-2.7
Number of licking bursts2.83.35.20.22.3-1.31.8-2.12.22.1-1.51.81.8-1.72.21.8-1.52.2
Food consumed during 24 hour testing period0.91.12.51.6-0.71.5-1.11.0-0.8-1.01.1-1.1-0.91.0-0.9-0.91.2-0.9
Times rat made contact with spout0.50.61.7-1.10.5-1.30.9-1.00.81.0-0.10.60.2-0.60.70.6-0.00.9
Mean time between licks in bursts0.00.00.10.20.10.3-0.20.3-0.2-0.3-0.30.10.10.1-0.10.2-0.3-0.2
Mean num. licks in bursts1.21.42.5-0.8-1.60.3-1.01.1-1.3-1.11.3-1.2-1.41.0-1.3-1.21.3-1.3
Std. dev. time between licks in bursts0.40.51.91.3-0.11.4-0.80.8-0.7-0.80.0-0.50.10.5-0.5-0.30.0-0.7
Water consumed over 24 hours0.50.61.10.5-0.70.6-0.70.7-0.6-0.71.0-0.8-0.80.8-0.7-0.71.0-0.6
Indifference point 0 sec0.10.20.30.3-0.20.5-0.50.5-0.4-0.60.3-0.4-0.20.5-0.5-0.10.3-0.4
Indifference point AUC0.40.40.8-0.90.6-0.90.7-0.60.60.6-0.50.60.8-0.60.60.8-0.50.5
Indifference point function ln k0.30.40.70.5-0.80.7-0.60.6-0.6-0.60.4-0.6-0.60.6-0.6-0.90.4-0.7
Indifference point function log k0.30.40.70.5-0.80.7-0.60.6-0.6-0.60.4-0.6-0.60.6-0.6-0.90.4-0.7
Delay discounting total patch changes 0 sec0.20.30.50.5-0.40.7-0.70.7-0.6-0.70.4-0.5-0.30.7-0.7-0.30.4-0.6
Delay discounting total patch changes 12 sec0.00.10.5-0.7-0.1-0.20.00.1-0.2-0.20.1-0.20.2-0.3-0.10.20.1-0.2
Delay discounting total patch changes 18 sec0.00.00.30.50.30.3-0.1-0.00.2-0.00.00.10.00.30.00.20.00.1
Delay discounting total patch changes 24 sec1.01.33.01.7-0.71.4-1.30.9-0.8-1.01.1-1.0-1.11.3-0.9-1.11.2-0.8
Delay discounting total patch changes 6 sec0.10.10.2-0.3-0.10.1-0.40.4-0.3-0.50.1-0.10.20.5-0.40.10.1-0.3
Delay discounting time to switch 0 sec0.60.91.8-1.30.7-1.11.0-0.70.70.8-0.90.80.9-1.30.81.0-0.90.8
Delay discounting water rate 0 sec0.60.91.3-0.21.1-0.80.8-0.91.00.9-1.01.11.0-0.61.01.1-1.11.0
Delay discounting water rate 12 sec0.81.12.61.4-0.71.1-1.10.9-0.8-0.81.1-0.8-1.21.6-0.7-1.21.1-0.8
Delay discounting water rate 18 sec0.10.20.3-0.10.5-0.40.3-0.50.40.5-0.30.40.2-0.10.40.4-0.40.5
Delay discounting water rate 24 sec0.30.44.22.10.41.0-0.3-0.10.30.1-0.00.0-0.30.40.3-0.3-0.10.2
Delay discounting water rate 6 sec1.32.04.32.1-0.81.8-1.61.3-1.1-1.31.2-1.1-1.51.9-1.2-1.11.2-1.1
Locomotor activity0.71.15.9-2.40.4-1.61.0-0.80.50.7-1.00.90.7-1.00.51.1-0.90.6
Locomotor testing distance0.50.92.8-1.70.4-1.30.9-0.80.60.8-1.11.00.5-0.90.60.9-1.00.7
Locomotor testing rearing1.93.03.8-1.21.6-1.91.7-1.91.81.8-1.82.01.5-1.41.71.6-1.91.9
Light reinforcement 10.10.10.30.30.6-0.00.3-0.20.40.2-0.30.40.4-0.00.30.4-0.30.4
Light reinforcement 22.53.34.6-1.11.9-1.81.9-1.81.81.8-1.81.81.9-1.81.82.1-1.81.9
Reaction time number correct0.00.00.2-0.20.1-0.30.1-0.20.10.20.10.2-0.00.40.10.20.00.2
Reaction time mean minus median0.60.81.30.6-0.80.7-1.01.1-1.0-1.10.9-0.8-0.71.1-1.0-0.70.9-0.9
Reaction time mean minus median AUC1.31.73.20.7-1.10.9-1.41.5-1.4-1.51.3-1.0-1.21.8-1.4-1.01.3-1.3
Reaction time num false alarms0.81.11.5-0.31.2-0.91.0-1.11.11.0-1.21.20.9-0.81.01.1-1.11.1
Reaction time num false alarms AUC0.91.31.8-0.51.3-1.01.2-1.21.21.1-1.31.31.1-1.01.11.3-1.21.2
Reaction time trials correct on left0.00.00.2-0.20.1-0.30.1-0.20.10.20.10.2-0.00.40.10.20.00.2
Reaction time trials on left0.00.00.2-0.30.1-0.40.1-0.20.10.20.00.2-0.00.40.10.20.00.2
Reaction time mean0.30.30.80.9-0.30.5-0.60.6-0.4-0.60.7-0.4-0.70.9-0.6-0.40.6-0.4
Reaction time mean AUC0.20.20.60.6-0.20.3-0.40.5-0.4-0.50.6-0.3-0.50.8-0.5-0.10.6-0.3
Median of all reaction times0.10.10.50.7-0.10.2-0.20.2-0.1-0.20.4-0.1-0.40.5-0.2-0.10.3-0.1
Reaction time omissions0.00.10.2-0.40.1-0.4-0.00.2-0.2-0.2-0.20.3-0.10.4-0.20.3-0.2-0.1
Reaction time false alarm rate0.60.81.2-0.21.0-0.60.9-0.91.00.8-1.11.00.8-1.00.91.0-1.00.9
Reaction time premature initiation rate0.10.10.90.90.00.7-0.40.3-0.1-0.2-0.0-0.2-0.20.2-0.1-0.10.0-0.3
Reaction time premature initiations0.10.10.60.80.10.5-0.30.1-0.0-0.1-0.10.0-0.10.4-0.10.1-0.0-0.1
Std. dev. reaction times0.91.32.51.4-0.81.1-1.21.3-1.0-1.21.1-0.9-1.11.6-1.1-0.91.1-1.0
Reaction time trials completed0.00.00.2-0.30.1-0.40.1-0.20.10.20.00.2-0.00.40.10.20.00.2
Reaction time trials AUC0.10.10.3-0.60.2-0.60.2-0.30.20.3-0.10.40.10.30.20.3-0.10.2
Social response proportion2.12.33.10.9-1.51.7-1.51.6-1.5-1.61.6-1.8-1.11.2-1.6-1.51.5-1.7
Social responses0.60.81.60.2-0.91.0-1.01.2-1.0-1.20.8-0.9-0.10.8-1.2-0.40.7-1.3
Social time3.03.95.92.4-1.72.3-2.11.9-1.7-1.91.9-1.9-1.82.1-1.9-1.91.9-1.9
Conditioned locomotion0.60.81.1-0.20.9-0.60.9-1.00.91.0-1.00.80.8-1.11.00.8-1.00.9
Cocaine response after cond. corrected0.30.32.9-1.7-0.0-0.90.4-0.1-0.10.1-0.40.30.4-0.40.10.2-0.40.1
Cocaine response after cond. not corrected0.40.44.2-2.0-0.3-1.00.30.2-0.3-0.1-0.40.20.3-0.3-0.20.1-0.4-0.2
Cocaine response before conditioning1.31.62.10.6-1.41.1-1.31.4-1.4-1.31.2-1.2-1.41.3-1.5-1.21.2-1.4
Saline control response0.00.10.4-0.6-0.2-0.30.1-0.1-0.00.0-0.30.10.2-0.20.0-0.2-0.3-0.0
Condit. Reinf. active minus inactive responses1.31.62.50.4-1.41.3-1.31.5-1.4-1.41.1-1.3-0.91.1-1.4-1.41.1-1.6
Condit. Reinf. active-inactive response ratio0.10.10.2-0.20.1-0.20.2-0.30.20.3-0.30.20.5-0.30.3-0.1-0.30.1
Condit. Reinf. active responses3.54.86.01.4-2.22.3-2.32.4-2.3-2.42.1-2.2-1.92.2-2.3-2.22.0-2.5
Condit. Reinf. inactive responses4.75.87.92.2-2.12.8-2.62.7-2.4-2.62.3-2.4-2.22.5-2.5-2.12.3-2.5
Condit. Reinf. lever presses7.310.011.81.3-3.32.9-3.23.2-3.3-3.23.4-3.4-3.13.0-3.3-3.33.4-3.4
Condit. Reinf. lever reinforcers received3.75.26.51.8-2.22.6-2.42.4-2.3-2.42.2-2.3-2.02.3-2.3-2.42.2-2.4
Pavlov. Cond. lever latency5.06.97.9-1.72.5-2.72.7-2.72.62.7-2.82.82.6-2.62.62.6-2.82.7
Pavlov. Cond. magazine entry latency2.93.34.01.0-1.81.8-1.81.9-1.9-2.02.0-2.0-1.71.7-1.9-1.72.0-1.9
Pavlov. Cond. change in total contacts8.311.613.92.8-3.23.7-3.63.4-3.3-3.43.4-3.5-3.43.5-3.3-3.63.4-3.4
Pavlov. Cond. index score5.26.98.51.8-2.52.7-2.72.6-2.6-2.62.9-2.8-2.72.6-2.6-2.62.9-2.6
Pavlov. Cond. latency score4.96.37.61.7-2.42.6-2.52.5-2.5-2.52.8-2.7-2.52.4-2.5-2.42.8-2.5
Pavlov. Cond. lever contacts4.76.58.41.9-2.42.6-2.62.5-2.4-2.52.9-2.7-2.62.6-2.4-2.62.9-2.5
Pavlov. Cond. magazine entry number4.04.96.4-1.52.2-2.12.2-2.12.22.1-2.52.42.4-2.22.12.3-2.52.1
Pavlov. Cond. intertrial magazine entries0.91.21.7-0.61.1-1.11.0-1.01.11.0-1.21.31.2-0.90.91.3-1.21.0
Pavlov. Cond. lever-magazine prob. diff.5.26.78.31.6-2.52.5-2.62.6-2.6-2.62.9-2.8-2.72.6-2.6-2.62.9-2.6
Pavlov. Cond. response bias5.47.49.22.3-2.52.9-2.82.6-2.5-2.63.0-2.8-2.82.8-2.5-2.83.0-2.6
Conditioned reinforcement - actives0.20.20.3-0.30.3-0.30.5-0.50.40.5-0.40.40.3-0.40.50.2-0.40.4
Conditioned reinforcement - inactives0.80.94.02.0-0.21.8-0.90.8-0.5-0.80.8-0.9-0.60.9-0.5-0.80.8-0.6
Conditioned locomotion2.32.73.5-0.21.9-1.01.7-1.81.91.8-1.71.61.7-1.71.81.7-1.71.8
Intermittent access intake day 1-15 change2.52.54.21.3-1.41.5-1.51.6-1.4-1.61.6-1.4-1.82.0-1.5-1.81.6-1.6
Intermittent access intake escalation2.52.54.21.5-1.41.6-1.51.5-1.4-1.51.6-1.4-1.82.0-1.4-1.71.6-1.5
Intermittent access intake escalation 21.81.72.40.7-1.41.1-1.11.3-1.3-1.31.4-1.4-1.31.4-1.3-1.51.4-1.4
Intermitt. access day 1 inactive lever presses3.74.05.20.7-1.82.0-2.02.3-2.2-2.32.3-2.2-1.42.0-2.2-1.52.3-2.1
Intermitt. access day 15 inactive lever presses0.60.71.61.1-0.41.3-0.90.9-0.7-0.90.9-0.8-0.20.8-0.7-0.50.9-0.8
Intermitt. access escalation Index0.20.20.70.80.40.10.3-0.50.60.5-0.60.40.2-0.40.50.1-0.60.4
Intermittent access day 1 total infusions2.22.53.70.71.9-0.61.5-1.81.91.8-1.71.61.4-1.61.91.4-1.71.9
Intermittent access day 15 total infusions0.30.43.61.90.50.90.0-0.20.40.2-0.10.0-0.10.10.4-0.3-0.10.4
Intermittent access terminal intake (last 3 days)0.40.52.41.50.80.60.5-0.60.80.6-0.50.40.4-0.40.80.0-0.50.7
Intermittent access total infusions0.60.71.81.31.00.30.7-0.91.00.9-0.80.60.6-0.71.00.4-0.81.0
Intermittent access day 1 locomotion1.11.11.91.01.40.10.9-1.11.31.1-1.00.91.1-1.11.21.0-1.01.1
Intermittent access day 15 total locomotion0.30.33.11.80.50.9-0.0-0.20.50.2-0.10.1-0.20.30.3-0.0-0.10.2
Intermittent access total locomotion1.11.32.00.61.4-0.31.1-1.21.31.2-1.11.11.1-1.11.31.2-1.11.2
Intermittent access standard deviation5.66.08.12.5-2.22.8-2.42.4-2.2-2.42.5-2.5-2.42.5-2.3-2.62.5-2.4
Cocaine induced anxiety0.40.50.7-0.0-0.80.5-0.70.8-0.8-0.80.8-0.8-0.50.5-0.8-0.60.8-0.8
Post-drug Anxiety0.10.10.7-0.80.1-0.30.20.0-0.1-0.00.0-0.10.7-0.60.10.30.0-0.0
Baseline Anxiety1.11.12.2-0.31.3-0.81.1-1.01.11.0-1.01.11.5-1.11.11.3-1.01.1
Lifetime Intake0.70.81.20.81.1-0.10.9-1.01.11.0-0.90.80.6-0.91.10.6-0.91.1
Incentive Sensitization - Responses0.20.20.30.50.30.10.4-0.50.50.5-0.40.2-0.1-0.50.5-0.1-0.40.4
Incentive Sensitization - Breakpoint0.10.10.30.50.30.10.4-0.50.50.5-0.40.3-0.2-0.40.5-0.1-0.40.4
Progressive ratio test 1 active lever presses0.60.63.61.9-0.31.4-0.70.4-0.3-0.40.5-0.6-0.70.6-0.4-0.70.5-0.4
Progressive ratio test 1 breakpoint0.90.93.11.8-0.61.5-0.90.7-0.6-0.70.8-0.9-0.90.8-0.7-0.90.8-0.7
Progressive ratio test 1 inactive lever presses0.60.62.61.6-0.21.5-0.70.6-0.4-0.60.7-0.7-0.30.7-0.4-0.60.7-0.6
Progressive ratio test 2 active lever presses0.20.21.81.30.10.80.0-0.20.30.2-0.1-0.1-0.3-0.10.3-0.4-0.10.2
Progressive ratio test 2 breakpoint0.10.21.31.20.20.60.2-0.30.30.3-0.2-0.0-0.2-0.30.3-0.3-0.20.2
Progressive ratio test 2 inactive lever presses0.91.16.12.5-0.32.2-0.80.6-0.3-0.60.6-1.0-0.30.3-0.3-1.00.6-0.7
Total sessions with >9 infusions1.11.21.4-0.71.2-1.01.1-1.11.11.1-1.11.21.0-1.01.11.2-1.11.2
Short access day 1 total inactive lever presses0.40.43.51.90.11.4-0.40.2-0.0-0.20.2-0.4-0.20.30.0-0.40.2-0.1
Short access day 10 total inactive lever presses1.41.52.71.4-1.21.6-1.21.2-1.1-1.21.1-1.3-0.91.0-1.2-1.21.1-1.4
Short access day 1 total infusions0.10.10.20.20.4-0.10.3-0.40.50.4-0.40.40.3-0.40.50.1-0.40.4
Short access day 10 total infusions0.40.50.70.20.8-0.40.7-0.70.80.7-0.70.70.4-0.70.70.7-0.70.8
Short access total infusions1.01.11.3-0.41.1-0.91.2-1.21.11.2-1.11.10.8-1.11.11.0-1.11.2
Short access day 1 locomotion0.20.20.9-0.30.8-0.40.5-0.30.40.3-0.30.60.50.10.30.9-0.30.5
Short access day 10 total locomotion0.70.82.01.3-0.51.4-0.90.9-0.8-0.90.9-0.9-0.60.8-0.8-0.40.9-1.0
Short access total locomotion0.80.81.5-0.51.1-0.60.9-0.90.90.9-0.80.91.0-0.90.81.2-0.80.8
Compulsive drug intake0.00.00.20.1-0.20.1-0.20.2-0.2-0.20.1-0.2-0.20.3-0.1-0.50.1-0.0
One hour access (0.3 mA shock)1.21.44.32.1-0.71.9-1.10.9-0.8-0.91.0-1.1-1.01.1-0.8-1.21.0-0.8
One hour access (shock baseline)0.10.21.41.20.10.9-0.10.00.1-0.00.1-0.2-0.10.00.1-0.20.1-0.1
Number of responses in last shaping day0.30.31.51.20.40.60.2-0.40.50.4-0.50.10.2-0.40.6-0.3-0.50.1
Context. condit. distance diff. score0.10.11.21.10.30.4-0.0-0.20.30.2-0.20.10.2-0.00.3-0.0-0.20.3
Locomotion velocity, session 10.70.81.5-1.20.5-1.21.0-1.00.81.0-0.60.70.7-1.00.80.8-0.60.8
Locomotion distance, session 10.50.61.51.2-0.71.0-0.80.5-0.4-0.50.9-0.8-0.70.7-0.6-0.91.0-0.6
Locomotion velocity, session 20.60.81.3-0.80.7-0.90.9-0.80.80.8-1.00.81.1-1.10.80.9-0.90.7
Locomotion distance, session 21.21.72.50.31.5-0.71.2-1.41.61.4-1.31.41.4-1.31.51.4-1.31.4
Locomotion velocity, session 30.20.30.4-0.20.6-0.50.5-0.50.60.5-0.50.60.7-0.40.50.5-0.40.5
Locomotion distance, session 33.03.36.42.5-1.42.5-1.91.9-1.5-1.91.5-1.7-1.21.9-1.6-1.81.5-1.7
Stereotopy head waving bouts, day 30.91.15.4-2.30.5-1.61.0-0.80.50.8-0.80.80.6-1.10.61.1-0.80.6
Stereotopy head waving duration, day 31.72.16.5-2.61.0-2.11.5-1.31.01.3-1.11.20.9-1.61.11.6-1.11.2
Locomotion velocity, session 70.30.41.71.3-0.41.0-0.70.4-0.3-0.50.3-0.4-0.40.7-0.5-0.60.4-0.5
Locomotion distance, session 70.10.10.40.6-0.40.4-0.40.3-0.2-0.30.1-0.2-0.10.5-0.4-0.60.2-0.4
Stereotopy head waving bouts, day 70.91.01.60.11.2-0.61.0-1.21.11.1-1.11.00.7-1.01.30.9-1.01.2
Stereotopy head waving duration, day 72.32.83.3-0.81.8-1.51.7-1.81.71.8-1.81.71.4-1.71.81.7-1.71.8
Locomotion velocity, session 83.64.35.8-0.12.4-1.52.1-2.32.42.2-2.02.12.3-2.12.22.2-2.02.3
Locomotion distance, session 80.71.11.81.31.3-0.00.8-1.01.31.0-1.01.01.2-0.81.20.8-0.91.1
Degree of sensitization distance0.60.61.5-1.20.4-1.20.8-0.80.60.8-0.60.70.5-0.80.60.6-0.70.7
Degree of sensitization stereotypy1.21.32.10.51.4-0.51.0-1.21.31.2-1.21.10.9-1.01.41.0-1.11.3
Condit. Reinf. active minus inactive responses0.20.20.4-0.30.5-0.40.5-0.50.40.5-0.20.40.4-0.60.50.6-0.20.5
Condit. Reinf. active-inactive response ratio0.30.31.9-1.40.3-0.90.5-0.30.10.3-0.10.20.3-0.60.30.7-0.10.3
Condit. Reinf. active responses2.22.63.2-0.41.8-1.31.7-1.81.81.8-1.61.61.6-1.81.81.8-1.61.8
Condit. Reinf. inactive responses2.53.04.20.61.9-0.91.6-1.92.01.9-1.91.81.8-1.71.91.6-1.91.9
Incentive salience index mean0.10.20.4-0.10.6-0.20.4-0.40.40.4-0.20.30.5-0.50.50.7-0.20.4
Condit. Reinf. lever presses0.00.00.20.50.10.4-0.10.2-0.1-0.20.2-0.20.1-0.0-0.10.20.2-0.1
Time in familiar zone, hab. session 10.30.30.7-0.7-0.9-0.2-0.30.3-0.5-0.30.6-0.5-0.50.4-0.5-0.80.7-0.5
Time in novel zone, hab. session 11.00.92.00.31.4-0.40.9-0.81.00.8-1.01.01.0-0.91.11.2-1.11.0
Total zone transitions, hab. session 10.10.10.50.70.20.30.1-0.30.30.30.0-0.00.1-0.20.3-0.10.00.2
Total locomotion distance, hab. session 11.01.41.90.6-1.21.3-1.21.2-1.2-1.21.3-1.4-1.20.9-1.1-1.21.3-1.3
Locomotion velocity, hab. session 10.60.81.10.2-1.00.8-0.80.9-1.0-0.91.0-1.1-0.90.6-0.9-0.91.0-1.0
Time in familiar zone, hab. session 21.92.03.3-0.3-1.61.0-1.41.7-1.7-1.71.3-1.5-1.21.3-1.7-1.21.3-1.8
Time in novel zone, hab. session 21.21.22.0-0.21.2-1.01.1-1.31.31.3-1.01.10.9-1.11.31.0-1.01.4
Total zone transitions, hab. session 22.93.84.7-0.72.1-1.62.0-2.12.12.1-1.81.92.0-2.12.22.0-1.92.1
Total locomotion distance, hab. session 20.10.10.30.40.60.10.3-0.30.40.3-0.00.20.2-0.40.50.4-0.00.3
Locomotion velocity, hab. session 20.10.20.40.10.6-0.10.4-0.40.50.4-0.20.30.4-0.50.50.6-0.20.4
Novel to familiar place preference ratio0.20.20.40.7-0.20.6-0.50.5-0.4-0.50.4-0.4-0.40.5-0.3-0.40.4-0.3
Novelty place preference0.10.10.60.8-0.10.5-0.40.4-0.2-0.40.3-0.3-0.30.5-0.2-0.40.3-0.2
Time in novel zone, NPP test0.10.10.50.70.10.4-0.20.1-0.0-0.10.1-0.1-0.10.20.1-0.20.10.0
Total zone transitions, NPP test0.10.10.2-0.10.2-0.30.3-0.50.40.5-0.30.30.3-0.40.30.2-0.20.4
Total locomotion distance, NPP test2.23.03.60.5-1.91.5-1.71.7-1.8-1.71.9-1.9-1.81.6-1.8-1.81.9-1.8
Locomotion velocity, NPP test2.33.34.10.4-2.01.5-1.81.8-1.9-1.82.0-2.0-2.01.6-1.9-1.92.0-2.0
Pavlov. Cond. lever latency0.10.20.50.3-0.60.3-0.40.3-0.4-0.30.3-0.4-0.70.5-0.4-0.70.4-0.4
Pavlov. Cond. magazine entry latency0.30.40.7-0.80.7-0.80.7-0.60.60.6-0.40.60.6-0.70.70.7-0.50.7
Pavlov. Cond. change in total contacts0.30.30.60.50.80.00.4-0.40.60.4-0.40.40.7-0.50.60.6-0.40.5
Pavlov. Cond. index score0.40.61.0-0.80.8-0.80.8-0.60.60.6-0.50.70.9-0.80.71.0-0.60.7
Pavlov. Cond. latency score0.20.30.6-0.50.7-0.40.6-0.40.40.4-0.40.50.7-0.60.50.7-0.40.5
Pavlov. Cond. lever contacts0.00.00.2-0.10.00.2-0.10.4-0.2-0.30.1-0.10.40.0-0.20.20.0-0.3
Pavlov. Cond. magazine entry number0.50.60.70.7-0.80.9-0.90.8-0.7-0.80.5-0.7-0.70.8-0.8-0.80.6-0.9
Pavlov. Cond. intertrial magazine entries1.01.11.6-0.40.9-0.91.1-1.11.11.1-1.31.11.3-1.11.10.9-1.21.0
Pavlov. Cond. lever-magazine prob. diff.0.50.71.2-0.71.0-0.80.9-0.70.70.7-0.60.80.9-0.90.81.1-0.60.8
Pavlov. Cond. response bias0.20.21.0-1.00.3-0.70.5-0.20.20.3-0.20.30.5-0.50.30.5-0.20.3
Bone: apparent density0.61.11.7-0.4-1.10.4-1.01.0-1.1-1.01.3-1.0-1.31.1-1.2-0.81.3-1.0
Bone surface1.62.93.51.2-1.61.7-1.81.7-1.6-1.61.9-1.7-1.81.8-1.8-1.61.9-1.7
Bone volume1.62.63.40.9-1.61.4-1.71.6-1.6-1.61.8-1.7-1.81.8-1.7-1.61.8-1.6
Bone: connectivity density0.30.40.7-0.2-0.60.4-0.60.8-0.7-0.70.8-0.6-0.70.7-0.9-0.30.8-0.7
Bone: cortical apparent density2.02.63.2-0.31.7-1.31.6-1.71.81.7-1.81.71.7-1.51.71.6-1.81.7
Bone: cortical area1.31.92.40.6-1.51.1-1.41.5-1.5-1.51.5-1.5-1.11.4-1.5-1.51.5-1.6
Bone: cortical porosity1.21.22.70.21.6-0.61.0-1.01.21.0-1.11.21.1-1.01.11.6-1.11.2
Bone: cortical porosity1.61.83.30.41.8-0.71.2-1.31.51.3-1.31.41.4-1.21.41.8-1.31.4
Bone: cortical thickness0.30.40.7-0.3-0.80.2-0.60.7-0.7-0.70.8-0.7-0.40.5-0.7-0.70.8-0.8
Bone: cortical thickness0.80.91.6-1.10.8-1.31.0-1.00.91.0-0.91.00.9-1.00.91.0-0.90.9
Bone: cortical tissue density2.43.13.8-0.31.8-1.41.7-1.81.91.9-1.91.91.8-1.71.81.8-1.91.9
Bone: elastic displacement0.00.00.4-0.6-0.1-0.40.1-0.0-0.1-0.0-0.10.0-0.0-0.1-0.10.0-0.1-0.1
Bone: elastic work1.82.33.00.5-1.61.2-1.51.5-1.6-1.51.7-1.7-1.71.4-1.6-1.51.7-1.6
Bone: endosteal estimation1.63.54.01.4-1.91.9-2.01.8-1.8-1.91.9-1.9-1.91.8-1.9-1.91.9-1.9
Bone: endosteal perimeter1.53.13.91.7-1.72.0-1.91.8-1.7-1.81.7-1.8-1.51.7-1.7-1.91.6-1.8
Bone: final force1.72.73.60.9-1.61.6-1.71.6-1.6-1.71.9-1.8-1.51.7-1.7-1.51.9-1.7
Bone: final moment2.13.44.10.9-1.81.7-1.91.9-1.9-1.92.0-2.0-1.71.9-1.9-1.82.0-1.9
Bone: marrow area1.73.64.11.4-1.91.9-2.01.9-1.9-2.02.0-2.0-1.91.9-2.0-1.91.9-1.9
Bone: maximum diameter1.52.73.11.0-1.61.5-1.71.8-1.7-1.71.8-1.7-1.51.7-1.7-1.61.7-1.8
Bone: maximum force2.74.76.11.3-2.12.1-2.22.1-2.1-2.22.5-2.3-2.12.2-2.2-2.12.4-2.2
Bone: maximum moment3.15.36.51.4-2.32.3-2.42.3-2.3-2.42.5-2.5-2.22.3-2.3-2.42.5-2.4
Bone: minimum diameter3.25.97.92.4-2.32.8-2.62.5-2.3-2.52.3-2.5-2.12.4-2.3-2.62.3-2.5
Bone: periosteal estimation2.04.24.81.3-2.11.9-2.22.1-2.1-2.12.2-2.2-1.92.0-2.1-2.12.1-2.1
Bone: periosteal perimeter1.22.02.70.6-1.61.3-1.41.5-1.5-1.51.4-1.6-1.21.2-1.5-1.61.4-1.6
Bone: post-yield work2.02.74.62.0-1.32.1-1.81.6-1.4-1.61.6-1.6-1.51.7-1.5-1.51.6-1.5
Bone: stiffness1.42.22.91.0-1.41.5-1.51.4-1.4-1.41.7-1.6-1.51.4-1.4-1.51.7-1.5
Bone: tissue strength3.93.75.11.9-1.52.3-2.12.0-1.8-2.02.0-1.9-1.82.1-1.8-1.92.0-1.8
Bone: trabecular number1.62.43.40.8-1.51.4-1.61.5-1.6-1.51.8-1.6-1.81.6-1.6-1.31.8-1.5
Bone: trabecular spacing0.20.20.5-0.5-0.60.1-0.40.6-0.7-0.60.2-0.4-0.40.4-0.5-0.50.2-0.6
Bone: trabecular thickness0.00.00.10.10.2-0.20.1-0.30.30.3-0.10.3-0.10.00.30.1-0.10.3
Bone: trabecular tissue density2.73.87.5-2.61.3-2.72.1-2.01.72.0-1.61.81.7-2.11.71.7-1.71.8
Breakpoint value in progressive ratio session1.21.43.11.2-1.21.8-1.21.1-1.0-1.01.1-1.5-0.80.7-1.0-1.31.1-1.3
Distance traveled before self-admin0.10.10.60.1-0.3-0.00.2-0.30.20.4-0.3-0.1-0.0-0.80.2-0.5-0.30.1
Distance traveled after self-admin3.84.25.01.1-2.12.2-2.12.1-2.1-2.22.1-2.2-1.92.0-2.1-2.22.0-2.1
Delta time in closed arm before/after self-admin2.72.63.50.9-1.71.3-1.71.6-1.6-1.51.9-1.7-1.81.7-1.7-1.51.8-1.6
Delta time in open arm before/after self-admin0.70.71.2-1.10.9-1.00.8-0.40.60.6-1.01.10.7-0.20.71.0-0.90.8
Diff in mean of infusions in LGA sessions0.50.61.60.20.60.00.7-0.80.90.9-1.00.50.9-1.30.90.4-1.00.5
Extinction: sum of active levers before priming3.23.24.2-0.0-2.01.5-1.71.8-1.9-1.72.0-1.9-2.01.7-1.9-1.72.1-2.0
Active lever presses in extinction session 62.42.34.5-0.6-2.10.7-1.31.5-1.7-1.51.6-1.7-1.41.1-1.8-1.61.6-1.9
Delta distance traveled before/after self-admin5.25.58.31.3-2.12.4-2.52.6-2.4-2.72.3-2.2-2.12.9-2.4-2.12.4-2.4
Delta ambulatory time before/after self-admin5.96.410.51.8-2.22.6-2.72.7-2.5-2.82.6-2.4-2.43.2-2.6-2.22.7-2.5
Time in closed arm before self-admin2.42.73.7-0.01.9-1.11.7-1.81.81.6-1.81.71.6-1.81.91.4-1.81.9
Time in closed arm after self-admin0.10.10.50.7-0.20.5-0.1-0.1-0.1-0.00.2-0.40.0-0.50.0-0.30.2-0.1
Time in open arm before self-admin4.85.17.20.6-2.41.7-2.32.3-2.4-2.32.7-2.5-2.02.2-2.6-1.92.7-2.5
Time in open arm after self-admin1.41.53.80.1-1.10.6-1.31.5-1.4-1.41.2-0.9-1.21.9-1.4-0.71.2-1.2
Sum of active levers in priming session hrs 5-60.10.10.20.2-0.40.4-0.30.3-0.2-0.20.3-0.4-0.30.1-0.3-0.30.2-0.4
Time to tail flick, vehicle, before self-admin1.11.11.5-0.11.0-0.81.0-1.21.21.1-1.11.01.0-1.21.11.0-1.11.0
Time to tail flick, vehicle, after self-admin0.00.00.2-0.4-0.2-0.00.1-0.0-0.2-0.2-0.0-0.20.4-0.4-0.00.0-0.1-0.2
Time to tail flick, test, before self-admin0.40.42.11.50.90.40.2-0.50.70.5-0.40.6-0.10.20.70.2-0.40.8
Time to tail flick, test, after self-admin0.00.00.20.10.20.10.00.10.10.00.10.1-0.10.50.00.10.1-0.0
Delta time to tail flick, vehicle, before/after SA0.80.81.30.1-0.80.8-0.91.1-1.1-1.21.0-0.9-0.61.0-1.0-0.70.9-0.9
Delta time to tail flick, test, before/after SA0.50.43.6-1.9-0.0-1.10.6-0.20.10.3-0.30.30.7-0.40.10.5-0.30.0
Ambulatory time before self-admin0.10.10.7-0.2-0.1-0.10.3-0.30.20.4-0.40.00.3-0.80.2-0.2-0.30.1
Ambulatory time after self-admin7.38.010.12.0-2.73.2-3.02.9-2.8-3.02.9-3.0-2.72.9-2.9-2.82.9-2.9
Total heroin consumption0.30.31.10.7-0.51.0-0.50.4-0.4-0.30.3-0.7-0.60.0-0.4-0.60.4-0.7
Area under the delay curve0.40.41.11.0-0.31.1-0.70.6-0.6-0.60.8-0.8-0.30.3-0.4-0.40.7-0.5
Delay disc. indifference point, 0s delay0.40.54.32.10.11.2-0.2-0.20.30.20.2-0.4-0.4-0.20.3-0.60.10.1
Delay disc. indifference point, 16s delay1.01.02.21.1-0.71.5-1.11.0-1.0-1.01.0-1.2-0.40.5-0.8-0.71.0-1.0
Delay disc. indifference point, 2s delay1.01.13.21.8-0.81.5-1.10.8-0.7-0.80.9-1.0-0.91.0-0.7-1.20.8-0.8
Delay disc. indifference point, 24s delay2.62.63.81.6-1.32.0-1.81.7-1.6-1.71.6-1.6-1.11.7-1.6-1.41.6-1.6
Delay disc. indifference point, 4s delay0.10.10.10.30.40.30.1-0.20.10.20.2-0.10.4-0.30.30.20.10.2
Delay disc. indifference point, 8s delay0.30.30.70.6-0.30.6-0.70.6-0.5-0.60.8-0.6-0.40.5-0.5-0.10.7-0.5
Delay discount exponential model param0.60.61.2-0.90.5-1.10.9-0.80.80.8-1.00.90.3-0.60.60.5-0.90.7
Delay discount hyperbolic model param0.40.41.1-1.00.3-1.00.7-0.60.60.6-0.90.80.3-0.50.50.4-0.70.5
Fecal boli incidents, locomotor time 12.42.64.3-1.61.3-1.61.9-1.51.51.5-1.61.41.8-2.11.41.8-1.71.3
Change in fecal boli incidents, locomotor task0.30.31.1-1.0-0.4-0.3-0.30.5-0.7-0.50.4-0.3-0.10.3-0.5-0.20.6-0.5
Time >=10cm from walls, locomotor time 10.00.00.1-0.30.2-0.20.20.0-0.0-0.00.2-0.00.1-0.10.00.30.20.1
Bouts of movement, locomotor time 10.60.62.71.6-0.61.4-0.60.5-0.3-0.50.7-0.9-0.60.4-0.4-1.10.6-0.5
Total resting periods, locomotor time 10.40.51.81.3-0.61.2-0.50.4-0.3-0.40.6-0.9-0.50.1-0.3-1.00.5-0.5
Rest time, locomotor task time 11.31.42.9-1.20.9-1.11.3-1.31.11.3-1.00.81.2-1.71.21.1-1.21.0
Distance moved, locomotor task time 10.10.10.60.8-0.10.3-0.50.2-0.0-0.2-0.10.1-0.30.6-0.1-0.4-0.0-0.2
Vertical activity count, locomotor time 12.32.44.81.4-1.21.6-1.91.7-1.5-1.71.4-1.2-1.42.2-1.6-1.31.6-1.5
Time >=10cm from walls, locomotor time 21.92.03.1-0.81.4-1.21.6-1.51.51.5-1.41.31.6-1.81.51.4-1.41.4
Bouts of movement, locomotor time 20.00.00.10.2-0.00.10.1-0.20.10.20.2-0.2-0.1-0.20.2-0.30.30.3
Total resting periods, locomotor time 20.00.00.1-0.10.1-0.10.2-0.30.20.30.0-0.00.2-0.30.3-0.00.10.3
Rest time, locomotor task time 20.50.51.0-0.90.6-0.80.8-0.70.60.7-0.60.51.0-0.90.70.8-0.60.7
Distance moved, locomotor task time 20.10.10.60.80.50.1-0.1-0.30.40.3-0.40.4-0.20.10.40.0-0.30.3
Vertical activity count, locomotor time 20.91.01.81.3-0.71.2-1.20.9-0.8-0.90.9-0.8-1.01.3-0.8-1.01.0-0.8
Weight adjusted by age0.10.10.70.1-0.10.0-0.40.3-0.3-0.30.6-0.2-0.40.8-0.3-0.10.6-0.0
Seeking ratio, delayed vs. immediate footshock1.61.85.42.3-0.91.8-1.41.3-1.1-1.31.3-1.3-1.31.2-1.0-1.41.1-1.0
Locomotion in novel chamber0.30.41.1-1.00.2-0.60.7-0.50.40.4-0.70.40.8-1.00.40.7-0.60.3
Locomotion in novel chamber post-restriction0.10.10.8-0.2-0.30.10.1-0.0-0.00.0-0.0-0.30.2-0.9-0.0-0.20.0-0.1
Progressive ratio0.00.00.1-0.1-0.10.1-0.00.2-0.1-0.2-0.0-0.10.0-0.1-0.20.30.0-0.1
Food seeking constrained by brief footshock3.13.84.51.0-2.02.0-2.02.1-2.0-2.12.0-2.1-1.91.8-2.1-1.92.0-2.0
Seeking ratio, punishment vs. effort0.60.81.11.0-0.71.0-0.90.8-0.7-0.80.9-0.9-0.80.9-0.7-1.00.9-0.8
Run reversals in cocaine runway, females0.70.71.71.0-0.50.9-0.90.8-0.6-0.80.7-0.6-0.91.3-0.7-0.70.7-0.6
Run reversals in cocaine runway, males0.60.65.6-2.4-0.1-1.40.40.2-0.4-0.20.20.20.1-0.0-0.30.70.2-0.1
Latency to leave start box in cocaine runway0.20.31.81.4-0.00.7-0.50.10.0-0.10.0-0.0-0.70.8-0.1-0.40.1-0.2
Latency to leave start box in cocaine runway, F0.10.10.91.00.30.4-0.20.00.2-0.0-0.00.2-0.20.70.10.10.10.0
Latency to leave start box in cocaine runway, M0.10.10.30.4-0.20.1-0.2-0.00.10.0-0.20.1-0.40.30.0-0.5-0.2-0.1
Cd content in liver0.10.10.3-0.1-0.3-0.0-0.20.0-0.1-0.10.4-0.2-0.60.3-0.2-0.20.3-0.1
Co content in liver0.30.41.0-0.60.7-0.60.6-0.40.40.4-0.70.70.7-0.50.41.0-0.70.5
Cu content in liver0.50.71.00.7-0.70.8-0.90.9-0.8-0.80.8-0.7-0.91.0-0.8-0.80.8-0.7
Fe content in liver0.00.00.00.10.20.00.1-0.20.20.1-0.10.10.2-0.20.10.2-0.10.1
K content in liver0.10.10.2-0.1-0.00.2-0.20.4-0.4-0.4-0.1-0.0-0.10.2-0.30.1-0.1-0.3
Mg content in liver0.50.61.2-1.10.7-0.80.7-0.40.40.4-0.90.80.8-0.70.51.0-0.90.5
Mn content in liver1.01.23.3-1.80.9-1.51.2-0.90.70.8-1.01.01.0-1.10.81.3-0.90.8
Na content in liver1.61.72.71.5-1.11.6-1.41.3-1.2-1.31.0-1.2-1.21.3-1.1-1.61.2-1.2
Rb content in liver0.10.10.50.70.50.30.1-0.10.30.1-0.40.30.3-0.10.30.3-0.40.2
Se content in liver7.79.311.3-2.43.0-3.23.2-3.13.02.9-3.03.13.2-3.12.93.4-3.03.0
Sr content in liver0.90.81.3-1.10.7-1.10.9-0.90.80.8-0.80.90.9-1.00.81.0-0.80.8
Zn content in liver0.10.10.3-0.20.4-0.20.2-0.10.10.1-0.30.30.4-0.10.10.5-0.40.2