Hub : Genes

Ddb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020715	0.15	0.06	6.2e-08	0.03	0.05	0.04	0.04	1.5e-04	7.4e-06	4.9e-05	4.5e-05
2	Brain	mRNA stability	ENSRNOG00000020715	0.06	0.04	4.1e-06	0.06	0.06	0.07	0.06	1.7e-06	3.4e-06	4.2e-07	1.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.4	4.6	4.9	2.1	-2.2
BMI without tail	1.7	3.6	3.9	2.0	-1.8
Body weight	2.1	8.8	11.5	3.4	-2.5
Epididymis fat weight	0.7	1.7	2.2	-1.1	1.5
Glucose	1.9	2.9	3.4	-1.6	1.9
Heart weight	0.1	0.1	0.2	-0.1	0.5
Left kidney weight	0.1	0.3	0.6	-0.1	0.8
Right kidney weight	0.0	0.1	0.2	-0.1	0.4
Tail length	1.1	3.2	4.6	2.1	-1.4
Length with tail	1.2	4.2	6.7	2.6	-1.3
Length without tail	0.3	0.6	1.0	1.0	-0.4
Liver weight, left	0.7	1.1	1.5	-0.8	1.2
Liver weight, right	0.5	0.9	1.5	-1.2	0.4
Parametrial fat weight	1.9	3.8	5.4	-1.5	2.3
Retroperitoneal fat weight	2.8	9.1	12.3	-2.4	3.5
Intraocular pressure	0.2	0.3	0.3	0.6	-0.6
Extensor digitorum longus weight	4.2	16.7	17.4	4.0	-4.2
Soleus weight	3.0	8.8	11.4	-3.4	2.5
Tibialis anterior weight	7.4	25.6	26.0	5.1	-5.0
Tibia length	0.3	0.9	1.7	1.3	-0.4
Number of licking bursts	0.0	0.1	0.1	0.2	0.2
Food consumed during 24 hour testing period	0.6	0.7	0.7	-0.8	0.8
Times rat made contact with spout	0.3	0.4	0.6	0.4	-0.8
Mean time between licks in bursts	1.3	1.8	3.2	0.7	-1.8
Mean num. licks in bursts	0.2	0.2	0.5	-0.1	-0.7
Std. dev. time between licks in bursts	0.4	0.5	0.8	-0.9	0.4
Water consumed over 24 hours	0.1	0.1	0.1	0.4	-0.2
Indifference point 0 sec	0.1	0.1	0.2	0.2	-0.4
Indifference point AUC	0.4	0.4	0.8	-0.3	-0.9
Indifference point function ln k	0.8	1.1	1.5	-0.8	1.2
Indifference point function log k	0.8	1.1	1.5	-0.8	1.2
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.2	-0.5
Delay discounting total patch changes 12 sec	3.5	4.6	5.5	1.9	-2.4
Delay discounting total patch changes 18 sec	0.1	0.2	0.3	-0.0	-0.6
Delay discounting total patch changes 24 sec	2.7	3.4	4.7	1.4	-2.2
Delay discounting total patch changes 6 sec	0.0	0.1	0.1	0.3	-0.2
Delay discounting time to switch 0 sec	0.2	0.3	0.7	0.8	-0.1
Delay discounting water rate 0 sec	1.1	1.7	2.8	-1.7	0.8
Delay discounting water rate 12 sec	0.7	1.0	1.5	-1.2	0.7
Delay discounting water rate 18 sec	0.9	1.2	1.5	-1.2	0.9
Delay discounting water rate 24 sec	0.3	0.4	0.7	-0.4	0.8
Delay discounting water rate 6 sec	0.4	0.6	0.7	-0.9	0.7
Locomotor activity	0.6	1.0	1.7	-1.3	0.5
Locomotor testing distance	0.7	1.2	2.3	-1.5	0.3
Locomotor testing rearing	0.8	1.3	2.5	-1.6	0.3
Light reinforcement 1	0.5	0.9	1.4	-1.2	0.6
Light reinforcement 2	2.1	2.8	3.1	-1.6	1.8
Reaction time number correct	1.5	2.2	4.1	2.0	-0.4
Reaction time mean minus median	0.8	1.1	1.7	1.3	-0.7
Reaction time mean minus median AUC	1.1	1.4	2.0	1.4	-0.9
Reaction time num false alarms	0.0	0.0	0.0	-0.1	-0.0
Reaction time num false alarms AUC	0.1	0.2	0.2	0.5	-0.4
Reaction time trials correct on left	1.5	2.2	4.1	2.0	-0.4
Reaction time trials on left	1.7	2.3	4.5	2.1	-0.4
Reaction time mean	0.1	0.1	0.3	0.1	-0.5
Reaction time mean AUC	0.1	0.1	0.1	-0.3	-0.3
Median of all reaction times	0.1	0.1	0.3	-0.0	-0.5
Reaction time omissions	0.6	0.8	1.5	1.2	-0.3
Reaction time false alarm rate	0.3	0.4	0.8	-0.9	0.1
Reaction time premature initiation rate	0.7	0.9	1.2	1.1	-0.8
Reaction time premature initiations	2.5	3.5	5.6	2.4	-1.2
Std. dev. reaction times	0.2	0.3	0.5	0.7	-0.4
Reaction time trials completed	1.7	2.3	4.5	2.1	-0.4
Reaction time trials AUC	1.3	1.9	3.7	1.9	-0.4
Social response proportion	0.5	0.6	1.1	-0.1	1.1
Social responses	0.2	0.2	0.5	-0.1	0.7
Social time	0.4	0.5	0.8	0.9	-0.4
Conditioned locomotion	0.7	0.9	1.1	1.1	-0.8
Cocaine response after cond. corrected	0.3	0.3	0.6	0.1	-0.8
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.6	-0.4
Cocaine response before conditioning	0.9	1.1	1.6	-1.3	0.8
Saline control response	1.7	2.2	2.4	1.6	-1.4
Condit. Reinf. active minus inactive responses	0.5	0.6	1.3	-1.1	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	-0.2
Condit. Reinf. active responses	0.3	0.5	0.9	-1.0	-0.1
Condit. Reinf. inactive responses	0.9	1.2	1.9	-1.4	0.7
Condit. Reinf. lever presses	0.1	0.2	0.3	0.2	-0.5
Condit. Reinf. lever reinforcers received	0.2	0.2	0.2	-0.5	-0.5
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.5	0.7
Pavlov. Cond. magazine entry latency	2.9	3.4	5.4	1.2	-2.3
Pavlov. Cond. change in total contacts	0.4	0.5	1.0	-0.3	-1.0
Pavlov. Cond. index score	1.3	1.7	2.8	0.7	-1.7
Pavlov. Cond. latency score	1.1	1.3	2.4	0.6	-1.5
Pavlov. Cond. lever contacts	0.5	0.8	1.5	-0.2	-1.2
Pavlov. Cond. magazine entry number	5.3	6.6	8.4	-2.2	2.9
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.9	-0.9	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	3.2	0.8	-1.8
Pavlov. Cond. response bias	1.0	1.4	2.8	0.3	-1.7
Conditioned reinforcement - actives	1.1	1.1	1.7	-1.3	0.7
Conditioned reinforcement - inactives	1.7	1.9	3.1	-1.8	0.9
Conditioned locomotion	2.8	3.4	5.2	-2.3	1.3
Intermittent access intake day 1-15 change	1.6	1.6	2.3	-1.5	0.9
Intermittent access intake escalation	1.0	1.0	1.7	-1.3	0.5
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.6	0.1
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.1	-1.5	1.0
Intermitt. access day 15 inactive lever presses	1.5	1.7	3.1	-1.8	0.5
Intermitt. access escalation Index	1.5	1.3	1.9	-1.4	0.9
Intermittent access day 1 total infusions	1.7	1.9	2.7	-1.6	1.0
Intermittent access day 15 total infusions	5.7	6.3	9.3	-3.0	1.9
Intermittent access terminal intake (last 3 days)	2.2	2.4	4.1	-2.0	0.9
Intermittent access total infusions	2.5	2.8	4.4	-2.1	1.0
Intermittent access day 1 locomotion	0.8	0.8	1.5	-1.2	0.4
Intermittent access day 15 total locomotion	0.6	0.6	1.2	-1.1	0.1
Intermittent access total locomotion	1.9	2.2	3.9	-2.0	0.6
Intermittent access standard deviation	0.1	0.1	0.1	-0.3	-0.3
Cocaine induced anxiety	0.4	0.4	0.5	0.5	-0.7
Post-drug Anxiety	0.9	0.9	1.0	1.0	-0.9
Baseline Anxiety	1.3	1.4	1.9	1.4	-1.0
Lifetime Intake	1.3	1.4	2.4	-1.6	0.7
Incentive Sensitization - Responses	0.4	0.4	0.5	-0.7	0.5
Incentive Sensitization - Breakpoint	0.7	0.7	0.9	-0.9	0.7
Progressive ratio test 1 active lever presses	1.9	2.0	2.6	-1.6	1.2
Progressive ratio test 1 breakpoint	1.7	1.7	2.1	-1.5	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.1	-0.5
Progressive ratio test 2 active lever presses	2.6	2.8	3.7	-1.9	1.4
Progressive ratio test 2 breakpoint	3.7	4.1	5.3	-2.3	1.7
Progressive ratio test 2 inactive lever presses	2.0	2.4	4.1	-2.0	0.8
Total sessions with >9 infusions	0.6	0.6	0.9	-0.9	0.6
Short access day 1 total inactive lever presses	1.0	1.1	1.3	-1.1	0.9
Short access day 10 total inactive lever presses	0.8	0.8	1.2	-1.1	0.7
Short access day 1 total infusions	0.2	0.2	0.3	-0.5	0.3
Short access day 10 total infusions	0.7	0.7	1.1	-1.1	0.5
Short access total infusions	0.2	0.2	0.3	-0.6	0.2
Short access day 1 locomotion	0.1	0.1	0.1	-0.1	-0.3
Short access day 10 total locomotion	0.1	0.1	0.2	-0.5	-0.3
Short access total locomotion	0.2	0.2	0.3	-0.3	-0.5
Compulsive drug intake	3.0	3.0	3.4	1.8	-1.6
One hour access (0.3 mA shock)	4.8	5.6	8.3	-2.9	1.7
One hour access (shock baseline)	7.2	8.4	10.4	-3.2	2.5
Number of responses in last shaping day	0.2	0.2	0.3	0.3	-0.5
Context. condit. distance diff. score	0.0	0.0	0.1	0.1	-0.2
Locomotion velocity, session 1	0.3	0.3	0.7	-0.1	-0.8
Locomotion distance, session 1	0.8	1.0	2.1	-0.0	-1.4
Locomotion velocity, session 2	1.3	1.5	2.5	0.7	-1.6
Locomotion distance, session 2	1.1	1.5	2.9	0.3	-1.7
Locomotion velocity, session 3	0.0	0.0	0.0	-0.1	-0.1
Locomotion distance, session 3	0.4	0.4	0.8	-0.2	0.9
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.7	-0.1
Stereotopy head waving duration, day 3	0.1	0.2	0.3	0.2	-0.5
Locomotion velocity, session 7	0.2	0.2	0.4	-0.0	0.6
Locomotion distance, session 7	0.0	0.0	0.0	0.0	0.2
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.7	-0.2
Stereotopy head waving duration, day 7	1.0	1.2	1.9	1.4	-0.7
Locomotion velocity, session 8	0.4	0.5	1.0	1.0	-0.1
Locomotion distance, session 8	0.1	0.1	0.2	-0.2	-0.4
Degree of sensitization distance	0.5	0.5	0.9	-0.1	-1.0
Degree of sensitization stereotypy	0.9	1.0	1.7	1.3	-0.5
Condit. Reinf. active minus inactive responses	1.0	1.1	2.1	0.0	-1.5
Condit. Reinf. active-inactive response ratio	1.4	1.5	3.0	0.3	-1.7
Condit. Reinf. active responses	0.8	1.0	1.5	-0.7	-1.2
Condit. Reinf. inactive responses	0.7	0.9	1.6	-1.3	0.3
Incentive salience index mean	0.5	0.6	0.6	-0.7	-0.8
Condit. Reinf. lever presses	0.7	0.9	1.4	-1.2	0.6
Time in familiar zone, hab. session 1	0.5	0.5	1.0	-1.0	-0.0
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.1	0.6
Total zone transitions, hab. session 1	0.3	0.5	0.5	0.6	-0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.2	-0.4
Locomotion velocity, hab. session 1	0.3	0.5	0.8	0.3	-0.9
Time in familiar zone, hab. session 2	0.3	0.4	0.6	-0.4	0.7
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.0	-0.8
Total zone transitions, hab. session 2	0.3	0.4	0.7	-0.4	-0.8
Total locomotion distance, hab. session 2	0.5	0.6	0.7	-0.9	-0.7
Locomotion velocity, hab. session 2	0.5	0.6	1.1	-1.0	-0.4
Novel to familiar place preference ratio	1.4	1.5	2.4	1.5	-0.8
Novelty place preference	1.1	1.2	2.0	1.4	-0.6
Time in novel zone, NPP test	1.8	1.9	2.8	1.7	-1.0
Total zone transitions, NPP test	0.8	1.1	2.0	0.5	-1.4
Total locomotion distance, NPP test	0.2	0.3	0.3	-0.6	-0.5
Locomotion velocity, NPP test	0.2	0.3	0.7	-0.8	-0.1
Pavlov. Cond. lever latency	0.4	0.6	1.1	1.0	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.3	-0.1
Pavlov. Cond. change in total contacts	0.7	0.8	1.5	-1.2	0.2
Pavlov. Cond. index score	0.2	0.2	0.4	-0.7	0.2
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.9	0.4
Pavlov. Cond. lever contacts	0.9	1.0	1.6	-1.3	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	-1.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.6	-0.1
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	-0.1
Bone: apparent density	0.1	0.2	0.3	-0.5	0.5
Bone surface	0.1	0.2	0.3	0.5	0.4
Bone volume	0.2	0.3	0.6	-0.2	0.8
Bone: connectivity density	0.1	0.1	0.1	0.4	-0.3
Bone: cortical apparent density	0.2	0.2	0.5	0.2	-0.7
Bone: cortical area	0.3	0.5	0.9	-0.9	0.3
Bone: cortical porosity	0.6	0.6	1.1	1.1	-0.4
Bone: cortical porosity	1.4	1.5	2.4	1.5	-0.8
Bone: cortical thickness	0.7	1.1	2.0	0.6	-1.4
Bone: cortical thickness	0.1	0.1	0.1	0.1	-0.3
Bone: cortical tissue density	0.3	0.4	0.7	0.4	-0.8
Bone: elastic displacement	0.0	0.1	0.1	-0.3	-0.2
Bone: elastic work	0.8	1.0	1.4	0.8	-1.2
Bone: endosteal estimation	1.9	4.0	4.4	-1.9	2.1
Bone: endosteal perimeter	2.7	5.6	7.0	-2.0	2.6
Bone: final force	0.2	0.3	0.5	-0.0	-0.7
Bone: final moment	0.1	0.2	0.5	-0.1	-0.7
Bone: marrow area	2.0	4.4	4.9	-2.0	2.2
Bone: maximum diameter	0.3	0.6	0.6	-0.8	0.8
Bone: maximum force	0.0	0.1	0.1	0.1	-0.3
Bone: maximum moment	0.0	0.1	0.1	-0.0	-0.3
Bone: minimum diameter	3.3	6.1	8.5	-2.9	1.9
Bone: periosteal estimation	1.2	2.4	2.8	-1.7	1.4
Bone: periosteal perimeter	0.8	1.2	1.6	-1.2	1.0
Bone: post-yield work	2.9	4.0	5.3	-1.6	2.3
Bone: stiffness	0.1	0.1	0.1	-0.3	0.4
Bone: tissue strength	1.0	1.0	1.4	-1.2	0.7
Bone: trabecular number	0.0	0.0	0.0	-0.0	-0.1
Bone: trabecular spacing	0.2	0.2	0.3	-0.4	-0.5
Bone: trabecular thickness	1.1	1.3	1.6	-1.0	1.3
Bone: trabecular tissue density	2.1	3.0	3.1	-1.7	1.8
Breakpoint value in progressive ratio session	3.1	3.5	4.0	2.0	-1.7
Distance traveled before self-admin	1.2	1.3	1.9	1.4	-0.8
Distance traveled after self-admin	0.0	0.0	0.0	0.1	-0.1
Delta time in closed arm before/after self-admin	4.4	4.3	4.5	2.0	-2.1
Delta time in open arm before/after self-admin	0.6	0.5	1.0	0.2	-1.0
Diff in mean of infusions in LGA sessions	2.6	2.9	3.4	1.9	-1.5
Extinction: sum of active levers before priming	2.9	2.9	3.8	1.9	-1.5
Active lever presses in extinction session 6	1.5	1.5	1.8	1.3	-1.1
Delta distance traveled before/after self-admin	0.2	0.3	0.4	-0.6	0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.5	0.4
Time in closed arm before self-admin	0.5	0.6	0.9	-0.4	1.0
Time in closed arm after self-admin	0.1	0.1	0.1	-0.1	0.3
Time in open arm before self-admin	0.1	0.1	0.1	-0.4	0.2
Time in open arm after self-admin	0.2	0.2	0.3	0.2	-0.6
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	0.6	-0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.6	-0.1
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.2	1.5	-0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.3	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.2	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.3	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.3	-0.5
Ambulatory time before self-admin	0.5	0.6	0.8	0.9	-0.6
Ambulatory time after self-admin	0.3	0.3	0.5	-0.7	0.4
Total heroin consumption	5.8	6.9	9.1	3.0	-2.2
Area under the delay curve	0.2	0.2	0.4	0.1	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.3	0.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.6	-0.6	1.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.4
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	0.4	0.8
Delay discount exponential model param	0.2	0.2	0.5	-0.0	-0.7
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.0	-0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.3	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	-0.2	0.9
Time >=10cm from walls, locomotor time 1	1.5	1.6	1.7	-1.3	1.2
Bouts of movement, locomotor time 1	1.7	1.9	2.2	1.3	-1.5
Total resting periods, locomotor time 1	0.8	0.9	1.0	0.9	-1.0
Rest time, locomotor task time 1	0.4	0.4	0.6	-0.5	0.8
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.4	-0.3
Vertical activity count, locomotor time 1	0.6	0.6	0.7	-0.7	0.8
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.3	0.5
Bouts of movement, locomotor time 2	4.4	4.8	7.5	1.4	-2.7
Total resting periods, locomotor time 2	3.7	3.9	6.7	1.1	-2.6
Rest time, locomotor task time 2	0.4	0.4	0.7	-0.8	0.4
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.7	0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.5	0.4
Weight adjusted by age	4.5	5.1	5.4	2.2	-2.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.7	-0.1
Locomotion in novel chamber	2.9	3.5	4.1	-1.7	2.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	-0.2	0.4
Progressive ratio	0.1	0.1	0.1	-0.3	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.4	-0.3
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.1	-0.6
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.2
Run reversals in cocaine runway, males	2.2	2.1	2.3	-1.4	1.5
Latency to leave start box in cocaine runway	1.7	1.9	2.8	-1.0	1.7
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	-0.5	0.8
Latency to leave start box in cocaine runway, M	3.0	2.8	4.6	-1.0	2.2
Cd content in liver	1.2	1.3	1.4	-1.2	1.1
Co content in liver	0.4	0.5	0.8	-0.9	0.4
Cu content in liver	0.5	0.6	0.8	0.9	-0.7
Fe content in liver	0.2	0.2	0.3	0.5	-0.3
K content in liver	0.2	0.2	0.4	-0.6	0.2
Mg content in liver	0.7	0.8	1.5	-1.2	0.2
Mn content in liver	0.2	0.2	0.3	0.5	-0.4
Na content in liver	0.1	0.1	0.2	-0.4	-0.1
Rb content in liver	1.6	2.0	2.8	-1.7	1.1
Se content in liver	0.2	0.2	0.3	0.5	-0.3
Sr content in liver	7.8	7.1	8.7	2.4	-2.9
Zn content in liver	2.0	2.2	4.3	0.3	-2.1