Spint2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020636	0.31	0.18	0.0e+00	0.1	0.1	0.1	0.11	1.7e-11	1.2e-11	4.6e-11	4.8e-12
2	Liver	gene expression	ENSRNOG00000020636	0.48	0.15	0.0e+00	0.28	0.28	0.28	0.29	3.7e-31	1.7e-31	1.3e-31	6.8e-32
3	Liver	intron excision ratio	chr1:84561924:84565165	0.04	0.03	1.0e-03	0.01	0.01	0.01	0.01	2.5e-02	7.9e-03	3.1e-02	2.2e-02
4	Liver	intron excision ratio	chr1:84561924:84580226	0.09	0.07	5.0e-07	0.03	0.03	0.04	0.03	3.3e-04	1.5e-04	8.8e-05	1.5e-04
5	Liver	intron excision ratio	chr1:84565335:84580226	0.03	0.03	4.8e-03	0	0	-0	0	7.4e-02	1.8e-01	4.1e-01	2.1e-01
6	NAcc	intron excision ratio	chr1:84561924:84580226	0.03	0.03	6.7e-03	0.04	0.02	0.03	0.04	4.0e-04	7.2e-03	1.8e-03	7.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.2	0.5	0.8	0.6	-0.6	0.7	-0.7	0.7	-0.9
BMI without tail	0.2	0.3	0.6	-0.5	0.4	-0.6	0.4	-0.7	0.8
Body weight	2.7	11.5	12.7	-3.4	3.3	-3.5	3.3	-3.6	3.3
Epididymis fat weight	0.0	0.0	0.1	0.2	-0.2	0.1	-0.1	0.0	-0.2
Glucose	0.3	0.4	0.5	0.7	-0.7	0.7	-0.7	0.5	-0.6
Heart weight	0.6	0.9	1.2	-1.1	1.1	-1.0	1.0	-0.9	0.4
Left kidney weight	2.6	7.4	8.8	-3.0	3.0	-2.8	2.9	-2.8	1.9
Right kidney weight	4.1	11.7	12.3	-3.5	3.4	-3.5	3.4	-3.5	3.2
Tail length	5.4	16.2	17.9	-3.8	3.8	-4.1	4.0	-4.2	4.1
Length with tail	8.0	29.5	31.6	-5.3	5.2	-5.5	5.3	-5.6	5.6
Length without tail	3.7	8.2	8.5	-2.9	2.9	-2.9	2.8	-2.8	2.8
Liver weight, left	0.2	0.3	1.6	0.2	-0.3	0.4	-0.3	0.2	-1.3
Liver weight, right	0.0	0.0	0.1	-0.2	0.1	-0.1	0.2	-0.1	-0.3
Parametrial fat weight	0.6	1.1	1.3	1.0	-1.0	1.1	-1.1	1.1	-1.1
Retroperitoneal fat weight	1.2	4.0	7.1	1.8	-1.8	1.9	-1.8	1.8	-2.7
Intraocular pressure	0.1	0.1	0.2	0.4	-0.3	0.2	-0.2	0.1	0.4
Extensor digitorum longus weight	0.2	0.8	0.9	0.9	-0.9	0.9	-0.9	0.9	-0.8
Soleus weight	0.8	2.3	2.5	1.6	-1.6	1.5	-1.6	1.5	-1.4
Tibialis anterior weight	0.0	0.0	0.2	-0.1	0.0	0.0	0.0	-0.0	-0.5
Tibia length	2.0	5.8	6.1	-2.5	2.4	-2.4	2.4	-2.4	2.2
Number of licking bursts	2.4	2.8	3.9	1.5	-1.5	1.7	-1.5	1.8	-2.0
Food consumed during 24 hour testing period	0.4	0.5	1.0	-0.6	0.6	-0.7	0.7	-0.6	1.0
Times rat made contact with spout	0.6	0.6	1.8	0.6	-0.6	0.7	-0.6	0.7	-1.4
Mean time between licks in bursts	0.1	0.2	0.3	-0.6	0.5	-0.4	0.4	-0.4	0.3
Mean num. licks in bursts	0.8	1.0	1.3	-1.0	1.0	-1.0	0.9	-1.1	0.8
Std. dev. time between licks in bursts	0.9	1.1	2.4	-0.9	0.8	-1.0	0.7	-1.1	1.5
Water consumed over 24 hours	0.7	0.8	1.1	-1.0	1.1	-0.9	0.9	-0.9	0.5
Indifference point 0 sec	0.2	0.4	0.6	-0.8	0.7	-0.6	0.8	-0.6	0.1
Indifference point AUC	0.3	0.3	0.4	0.7	-0.6	0.6	-0.5	0.6	-0.4
Indifference point function ln k	0.4	0.5	0.6	-0.8	0.8	-0.8	0.8	-0.7	0.5
Indifference point function log k	0.4	0.5	0.6	-0.8	0.8	-0.8	0.8	-0.7	0.5
Delay discounting total patch changes 0 sec	0.3	0.5	0.8	-0.8	0.8	-0.7	0.9	-0.7	0.2
Delay discounting total patch changes 12 sec	0.3	0.4	0.5	-0.7	0.6	-0.6	0.7	-0.7	0.6
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	0.3	-0.3	0.3	-0.2	0.3	-0.4
Delay discounting total patch changes 24 sec	0.8	1.0	1.3	-0.9	0.8	-0.9	1.1	-1.0	1.1
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	-0.4	0.3	-0.3	0.4	-0.4	0.0
Delay discounting time to switch 0 sec	1.0	1.6	2.3	1.4	-1.4	1.3	-1.5	1.2	-0.5
Delay discounting water rate 0 sec	0.5	0.9	1.8	0.8	-0.7	0.8	-0.8	0.9	-1.4
Delay discounting water rate 12 sec	0.8	1.2	1.6	-1.2	1.2	-1.1	1.2	-1.0	0.6
Delay discounting water rate 18 sec	0.6	0.8	1.1	0.9	-0.9	0.9	-1.0	1.1	-0.8
Delay discounting water rate 24 sec	0.3	0.4	0.7	-0.8	0.8	-0.7	0.6	-0.4	-0.1
Delay discounting water rate 6 sec	0.1	0.1	0.1	-0.2	0.3	-0.4	0.4	-0.2	0.3
Locomotor activity	0.4	0.7	1.0	0.7	-0.8	0.8	-0.9	0.8	-1.0
Locomotor testing distance	0.8	1.4	1.7	1.1	-1.1	1.2	-1.2	1.3	-1.1
Locomotor testing rearing	1.5	2.3	3.1	1.3	-1.4	1.5	-1.6	1.6	-1.8
Light reinforcement 1	0.2	0.3	0.7	0.5	-0.6	0.5	-0.4	0.4	-0.8
Light reinforcement 2	6.8	9.0	10.4	3.1	-3.1	3.1	-3.2	3.0	-2.2
Reaction time number correct	0.1	0.1	0.6	-0.3	0.4	-0.1	0.1	0.0	-0.8
Reaction time mean minus median	0.2	0.2	0.2	-0.5	0.5	-0.5	0.5	-0.4	0.4
Reaction time mean minus median AUC	0.2	0.3	0.4	-0.6	0.6	-0.6	0.6	-0.5	0.3
Reaction time num false alarms	1.0	1.3	1.9	1.0	-1.0	1.2	-1.2	1.1	-1.4
Reaction time num false alarms AUC	1.3	1.9	2.5	1.2	-1.2	1.4	-1.4	1.3	-1.6
Reaction time trials correct on left	0.1	0.1	0.6	-0.3	0.4	-0.1	0.1	0.0	-0.8
Reaction time trials on left	0.1	0.1	0.6	-0.3	0.4	-0.1	0.1	0.0	-0.8
Reaction time mean	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3	0.3	-0.3
Reaction time mean AUC	0.2	0.2	0.3	0.4	-0.4	0.5	-0.5	0.5	-0.5
Median of all reaction times	0.2	0.3	0.3	0.5	-0.5	0.6	-0.6	0.6	-0.5
Reaction time omissions	0.2	0.3	0.6	0.4	-0.4	0.5	-0.7	0.6	-0.7
Reaction time false alarm rate	1.0	1.5	1.7	1.3	-1.3	1.3	-1.3	1.1	-0.9
Reaction time premature initiation rate	0.0	0.0	0.3	-0.0	0.0	-0.1	0.1	-0.1	0.5
Reaction time premature initiations	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1	-0.0	0.1
Std. dev. reaction times	0.1	0.1	0.1	-0.4	0.4	-0.3	0.3	-0.2	0.2
Reaction time trials completed	0.1	0.1	0.6	-0.3	0.4	-0.1	0.1	0.0	-0.8
Reaction time trials AUC	0.1	0.2	0.9	-0.2	0.3	0.1	-0.0	0.2	-1.0
Social response proportion	4.2	4.6	5.4	-2.3	2.3	-2.3	2.0	-2.1	1.9
Social responses	0.2	0.2	0.9	-0.2	0.2	-0.4	0.1	-0.4	1.0
Social time	0.6	0.8	2.4	-0.6	0.6	-0.9	0.7	-0.8	1.6
Conditioned locomotion	0.3	0.4	0.6	-0.7	0.8	-0.5	0.5	-0.5	-0.4
Cocaine response after cond. corrected	0.3	0.3	0.5	-0.7	0.7	-0.6	0.6	-0.7	0.1
Cocaine response after cond. not corrected	0.5	0.6	0.9	-0.9	0.9	-0.8	0.7	-0.8	0.1
Cocaine response before conditioning	1.4	1.7	2.5	-1.6	1.6	-1.3	1.3	-1.2	0.8
Saline control response	0.4	0.5	0.6	-0.7	0.7	-0.7	0.8	-0.7	0.4
Condit. Reinf. active minus inactive responses	4.3	5.3	5.6	-2.4	2.4	-2.3	2.4	-2.2	2.2
Condit. Reinf. active-inactive response ratio	2.4	2.5	3.5	-1.8	1.9	-1.7	1.8	-1.5	0.6
Condit. Reinf. active responses	5.0	7.0	7.2	-2.6	2.6	-2.7	2.7	-2.6	2.7
Condit. Reinf. inactive responses	1.9	2.4	4.5	-1.4	1.3	-1.5	1.4	-1.5	2.1
Condit. Reinf. lever presses	7.5	10.3	12.6	-3.1	3.0	-3.2	3.2	-3.1	3.5
Condit. Reinf. lever reinforcers received	5.8	8.2	8.5	-2.9	2.9	-2.9	2.9	-2.8	2.7
Pavlov. Cond. lever latency	3.6	5.0	7.4	2.1	-2.0	2.2	-2.2	2.1	-2.7
Pavlov. Cond. magazine entry latency	2.1	2.5	4.1	-1.4	1.3	-1.5	1.5	-1.5	2.0
Pavlov. Cond. change in total contacts	7.0	9.8	13.9	-3.0	2.9	-3.1	3.0	-2.9	3.7
Pavlov. Cond. index score	3.4	4.5	7.4	-1.9	1.8	-2.1	2.0	-2.0	2.7
Pavlov. Cond. latency score	3.3	4.1	7.1	-1.8	1.8	-2.0	2.0	-1.9	2.7
Pavlov. Cond. lever contacts	3.4	4.7	6.8	-2.0	2.0	-2.2	2.1	-2.1	2.6
Pavlov. Cond. magazine entry number	1.7	2.1	5.2	1.1	-1.0	1.3	-1.3	1.3	-2.3
Pavlov. Cond. intertrial magazine entries	1.2	1.5	3.1	1.0	-0.9	1.2	-1.1	1.2	-1.8
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.8	6.9	-2.0	2.0	-2.2	2.2	-2.1	2.6
Pavlov. Cond. response bias	3.9	5.4	7.8	-2.2	2.1	-2.3	2.3	-2.2	2.8
Conditioned reinforcement - actives	0.3	0.3	0.6	-0.5	0.5	-0.4	0.6	-0.8	-0.2
Conditioned reinforcement - inactives	1.8	2.1	2.5	-1.4	1.4	-1.6	1.5	-1.5	1.1
Conditioned locomotion	1.5	1.8	3.9	1.1	-1.1	1.3	-1.2	1.1	-2.0
Intermittent access intake day 1-15 change	1.5	1.5	1.9	-1.1	1.0	-1.2	1.3	-1.4	1.2
Intermittent access intake escalation	1.1	1.1	1.5	-0.9	0.8	-1.0	1.1	-1.1	1.2
Intermittent access intake escalation 2	3.0	3.0	3.4	-1.7	1.6	-1.8	1.8	-1.8	1.6
Intermitt. access day 1 inactive lever presses	0.7	0.8	2.9	-0.4	0.3	-0.7	0.7	-0.8	1.7
Intermitt. access day 15 inactive lever presses	0.3	0.4	1.2	-0.3	0.2	-0.5	0.5	-0.7	1.1
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	0.4	-0.3	0.1	0.3	-0.1
Intermittent access day 1 total infusions	0.4	0.5	2.3	0.0	0.0	0.3	-0.2	0.8	-1.5
Intermittent access day 15 total infusions	0.6	0.7	1.0	-1.0	1.0	-0.9	1.0	-0.6	0.3
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.7	-1.3	1.3	-1.2	1.3	-1.0	0.2
Intermittent access total infusions	0.4	0.4	0.7	-0.8	0.8	-0.6	0.8	-0.3	-0.4
Intermittent access day 1 locomotion	0.2	0.2	1.1	-0.0	0.0	0.2	-0.1	0.3	-1.0
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	0.2	-0.4
Intermittent access total locomotion	0.5	0.6	1.4	0.6	-0.6	0.8	-0.6	0.6	-1.2
Intermittent access standard deviation	5.2	5.5	6.5	-2.1	2.1	-2.4	2.5	-2.4	2.5
Cocaine induced anxiety	0.1	0.1	0.6	-0.0	0.0	-0.1	-0.0	-0.5	0.8
Post-drug Anxiety	0.3	0.3	0.4	0.6	-0.7	0.6	-0.6	0.1	0.6
Baseline Anxiety	0.2	0.2	0.6	0.3	-0.3	0.4	-0.3	0.6	-0.8
Lifetime Intake	0.1	0.1	0.6	-0.3	0.3	-0.1	0.2	0.2	-0.8
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.0	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.3	-0.3	0.2	-0.1	0.1	0.1
Progressive ratio test 1 active lever presses	1.0	1.1	1.7	-1.3	1.3	-1.2	1.2	-0.5	0.2
Progressive ratio test 1 breakpoint	1.4	1.5	2.1	-1.4	1.4	-1.4	1.4	-0.7	0.5
Progressive ratio test 1 inactive lever presses	0.4	0.4	1.1	-0.4	0.4	-0.6	0.6	-0.7	1.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.7	-0.8	0.7	-0.8	0.8	-0.5	0.4
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	-0.8	0.8	-0.8	0.9	-0.5	0.2
Progressive ratio test 2 inactive lever presses	2.8	3.2	3.9	-1.6	1.6	-1.9	1.9	-1.7	2.0
Total sessions with >9 infusions	0.6	0.6	2.9	0.1	-0.0	0.4	-0.3	0.7	-1.7
Short access day 1 total inactive lever presses	0.6	0.7	1.5	-0.6	0.6	-0.7	0.8	-0.8	1.2
Short access day 10 total inactive lever presses	0.8	0.9	3.5	-0.4	0.3	-0.6	0.6	-1.1	1.9
Short access day 1 total infusions	0.2	0.2	0.4	-0.6	0.6	-0.5	0.4	0.0	-0.3
Short access day 10 total infusions	0.5	0.5	2.1	0.2	-0.2	0.5	-0.3	0.7	-1.4
Short access total infusions	0.6	0.6	2.5	0.4	-0.4	0.5	-0.4	0.8	-1.6
Short access day 1 locomotion	1.7	1.8	3.1	1.2	-1.3	1.3	-1.2	1.1	-1.8
Short access day 10 total locomotion	0.4	0.4	0.7	-0.7	0.6	-0.5	0.7	-0.9	0.3
Short access total locomotion	0.5	0.5	2.2	0.4	-0.4	0.6	-0.3	0.2	-1.5
Compulsive drug intake	0.6	0.6	1.3	-0.6	0.6	-0.6	0.5	-0.8	1.1
One hour access (0.3 mA shock)	1.3	1.5	1.9	-1.2	1.2	-1.2	1.3	-1.4	1.2
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	0.3	-0.4	0.4	-0.3	0.0
Number of responses in last shaping day	2.0	2.0	2.8	-1.6	1.7	-1.6	1.4	-1.2	0.9
Context. condit. distance diff. score	0.1	0.1	0.2	0.2	-0.2	0.3	-0.4	0.3	-0.1
Locomotion velocity, session 1	2.2	2.4	2.9	1.6	-1.6	1.6	-1.6	1.7	-0.9
Locomotion distance, session 1	0.8	1.0	1.4	-1.0	1.0	-1.0	1.2	-1.0	0.7
Locomotion velocity, session 2	0.3	0.4	0.8	0.6	-0.6	0.7	-0.9	0.5	-0.3
Locomotion distance, session 2	0.6	0.8	1.7	0.7	-0.7	0.9	-0.7	0.8	-1.3
Locomotion velocity, session 3	0.2	0.2	0.4	0.4	-0.3	0.5	-0.5	0.6	-0.6
Locomotion distance, session 3	5.8	6.3	6.9	-2.6	2.6	-2.6	2.5	-2.6	2.0
Stereotopy head waving bouts, day 3	0.6	0.8	1.3	0.6	-0.5	0.8	-1.0	1.0	-1.1
Stereotopy head waving duration, day 3	2.6	3.2	4.2	1.7	-1.7	1.8	-2.1	1.9	-1.5
Locomotion velocity, session 7	0.0	0.0	0.1	-0.0	-0.0	-0.1	-0.1	-0.1	0.3
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	-0.3	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.6	0.1	-0.1	0.2	-0.3	0.2	-0.8
Stereotopy head waving duration, day 7	1.1	1.3	2.2	1.0	-1.0	1.1	-1.2	1.1	-1.5
Locomotion velocity, session 8	3.4	4.1	5.2	1.8	-1.8	2.1	-2.1	2.1	-2.3
Locomotion distance, session 8	0.4	0.5	0.9	0.6	-0.6	0.7	-0.7	0.7	-1.0
Degree of sensitization distance	3.1	3.2	3.9	1.9	-1.9	1.8	-2.0	1.8	-1.0
Degree of sensitization stereotypy	0.1	0.2	0.9	-0.0	0.1	0.1	-0.0	0.1	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.4	-0.4	0.6	-0.5	0.7	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.3	-0.2	0.4	-0.5	0.6	-0.2
Condit. Reinf. active responses	1.1	1.4	2.0	1.0	-1.0	1.2	-1.0	1.3	-1.4
Condit. Reinf. inactive responses	0.9	1.0	2.3	0.9	-1.0	1.0	-0.7	0.9	-1.5
Incentive salience index mean	0.0	0.0	0.1	-0.0	0.0	0.2	-0.1	0.2	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.5	0.4	-0.4	0.5	-0.4	0.4
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	0.5	-0.5	0.5	-0.6	0.5
Time in novel zone, hab. session 1	0.3	0.3	0.9	0.3	-0.3	0.4	-0.4	0.4	-1.0
Total zone transitions, hab. session 1	0.5	0.6	1.0	-0.9	0.8	-0.8	1.0	-0.9	0.2
Total locomotion distance, hab. session 1	3.0	4.2	5.2	-2.1	2.0	-2.1	2.3	-2.2	1.7
Locomotion velocity, hab. session 1	1.3	1.9	2.5	-1.3	1.3	-1.4	1.6	-1.4	1.3
Time in familiar zone, hab. session 2	0.8	0.8	2.4	-0.6	0.6	-0.8	0.6	-0.7	1.6
Time in novel zone, hab. session 2	0.8	0.8	1.7	0.8	-0.8	0.8	-0.7	0.8	-1.3
Total zone transitions, hab. session 2	0.3	0.4	2.2	-0.0	0.0	0.4	-0.1	0.4	-1.5
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.9	0.9	-0.7	0.8	-0.6	-0.0
Locomotion velocity, hab. session 2	0.3	0.4	0.7	-0.8	0.8	-0.6	0.8	-0.5	-0.2
Novel to familiar place preference ratio	1.0	1.1	1.4	-1.0	1.0	-1.1	1.2	-1.2	0.6
Novelty place preference	0.9	0.9	1.3	-0.9	0.9	-1.0	1.1	-1.1	0.5
Time in novel zone, NPP test	0.5	0.5	0.8	-0.7	0.7	-0.8	0.9	-0.9	0.3
Total zone transitions, NPP test	0.1	0.2	0.2	0.4	-0.5	0.5	-0.3	0.4	-0.5
Total locomotion distance, NPP test	1.8	2.5	2.9	-1.5	1.5	-1.6	1.6	-1.6	1.7
Locomotion velocity, NPP test	2.3	3.2	3.5	-1.8	1.7	-1.8	1.9	-1.8	1.8
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.5	-0.5	0.3	-0.4	0.4	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	0.3	-0.3	0.4	-0.3	0.5	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	0.0	-0.3
Pavlov. Cond. index score	0.1	0.1	0.7	-0.2	0.1	0.0	0.1	0.0	-0.9
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.3	0.3	-0.1	0.2	-0.2	-0.5
Pavlov. Cond. lever contacts	0.7	0.8	1.1	-1.0	1.0	-0.9	1.0	-1.0	0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.8	-0.1	0.2	-0.3	0.2	-0.3	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.4	-0.3	0.4	-0.4	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.9	-0.4	0.4	-0.1	0.3	-0.1	-1.0
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.4	0.4	-0.2	0.3	-0.2	-0.4
Bone: apparent density	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4	0.2	0.2
Bone surface	0.3	0.6	1.3	-0.6	0.6	-0.6	0.5	-0.8	1.1
Bone volume	0.3	0.5	1.0	-0.6	0.6	-0.6	0.6	-0.7	1.0
Bone: connectivity density	0.4	0.7	1.0	0.9	-0.9	0.9	-1.0	0.7	-0.0
Bone: cortical apparent density	2.2	2.8	3.2	1.6	-1.6	1.8	-1.6	1.8	-1.7
Bone: cortical area	2.2	3.3	3.9	-2.0	2.0	-1.8	1.8	-1.8	1.5
Bone: cortical porosity	1.1	1.2	3.5	0.7	-0.7	1.0	-1.0	0.9	-1.9
Bone: cortical porosity	1.3	1.4	3.8	0.8	-0.8	1.0	-1.0	1.0	-2.0
Bone: cortical thickness	0.9	1.5	2.0	-1.4	1.4	-1.2	1.3	-1.1	0.7
Bone: cortical thickness	0.2	0.3	1.1	0.1	-0.1	0.4	-0.3	0.4	-1.1
Bone: cortical tissue density	2.6	3.4	3.8	1.8	-1.8	1.9	-1.8	1.9	-1.8
Bone: elastic displacement	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	0.2	-0.2
Bone: elastic work	2.3	2.9	3.5	-1.9	1.9	-1.7	1.7	-1.7	1.4
Bone: endosteal estimation	1.3	2.9	3.6	-1.6	1.6	-1.7	1.6	-1.8	1.9
Bone: endosteal perimeter	1.3	2.7	4.4	-1.4	1.4	-1.6	1.5	-1.7	2.1
Bone: final force	1.7	2.8	3.4	-1.8	1.8	-1.7	1.7	-1.7	1.2
Bone: final moment	2.5	4.2	5.0	-2.2	2.2	-2.1	2.1	-2.0	1.5
Bone: marrow area	1.4	3.0	3.6	-1.6	1.6	-1.7	1.7	-1.8	1.9
Bone: maximum diameter	1.5	2.8	3.0	-1.7	1.7	-1.7	1.6	-1.7	1.7
Bone: maximum force	3.0	5.2	6.0	-2.4	2.4	-2.3	2.3	-2.2	1.9
Bone: maximum moment	3.9	6.8	7.8	-2.8	2.8	-2.6	2.7	-2.6	2.1
Bone: minimum diameter	5.7	10.6	11.6	-3.4	3.4	-3.3	3.3	-3.2	2.8
Bone: periosteal estimation	2.2	4.6	4.7	-2.2	2.2	-2.2	2.1	-2.2	2.1
Bone: periosteal perimeter	2.0	3.4	4.0	-1.7	1.7	-1.8	1.8	-1.8	2.0
Bone: post-yield work	1.0	1.4	2.8	-1.0	1.0	-1.1	1.1	-1.1	1.7
Bone: stiffness	1.5	2.4	2.7	-1.6	1.6	-1.6	1.5	-1.5	1.4
Bone: tissue strength	4.3	4.2	4.6	-2.1	2.1	-2.1	2.2	-2.1	1.7
Bone: trabecular number	0.2	0.2	0.9	-0.3	0.3	-0.3	0.3	-0.5	0.9
Bone: trabecular spacing	1.6	2.1	2.5	-1.5	1.5	-1.5	1.6	-1.5	0.9
Bone: trabecular thickness	0.2	0.3	0.4	0.4	-0.4	0.5	-0.6	0.5	-0.6
Bone: trabecular tissue density	2.6	3.7	3.9	1.9	-1.9	1.9	-2.0	1.9	-1.8
Breakpoint value in progressive ratio session	2.0	2.3	4.7	-1.4	1.4	-1.5	1.2	-1.2	2.2
Distance traveled before self-admin	1.7	1.8	2.3	-1.5	1.5	-1.4	1.5	-1.2	0.9
Distance traveled after self-admin	5.6	6.2	7.2	-2.4	2.4	-2.5	2.7	-2.5	2.5
Delta time in closed arm before/after self-admin	0.7	0.7	1.2	-0.7	0.6	-0.8	0.7	-1.1	0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.9	0.1	-0.0	0.3	-0.1	0.6	-0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.4	0.4	-0.4	0.2	-0.2	0.5
Extinction: sum of active levers before priming	1.4	1.4	1.8	-1.1	1.0	-1.2	1.2	-1.2	1.3
Active lever presses in extinction session 6	0.9	0.9	3.0	-0.6	0.6	-0.7	0.5	-0.9	1.7
Delta distance traveled before/after self-admin	1.1	1.2	3.6	-0.6	0.6	-0.9	0.8	-1.2	1.9
Delta ambulatory time before/after self-admin	1.5	1.6	2.7	-1.0	1.0	-1.2	1.2	-1.4	1.6
Time in closed arm before self-admin	0.3	0.3	0.8	0.1	-0.1	0.3	-0.4	0.8	-0.9
Time in closed arm after self-admin	0.2	0.2	0.7	-0.4	0.3	-0.4	0.1	-0.4	0.9
Time in open arm before self-admin	1.6	1.7	2.2	-1.2	1.1	-1.3	1.2	-1.5	1.5
Time in open arm after self-admin	0.8	0.9	1.3	-1.1	1.2	-1.0	1.1	-0.8	0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.3	0.3	-0.2	0.1	-0.1	0.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	-0.5	0.4	-0.1	0.3	-0.4	-1.0
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.1	-0.4	0.4	-0.5	0.4	-0.3	1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.8	-0.3	0.2	-0.0	-0.0	-0.2	-0.9
Time to tail flick, test, after self-admin	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1	-0.2	-0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.2	-0.2	0.3	-0.4	0.2	-0.1	1.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	0.1	-0.2
Ambulatory time before self-admin	0.9	1.0	1.3	-1.1	1.1	-1.1	1.1	-0.8	0.6
Ambulatory time after self-admin	6.1	6.7	8.0	-2.4	2.4	-2.6	2.7	-2.5	2.8
Total heroin consumption	1.5	1.8	2.3	-1.4	1.4	-1.4	1.5	-1.3	0.9
Area under the delay curve	0.3	0.3	1.5	-0.1	0.0	-0.2	0.2	-0.4	1.2
Delay disc. indifference point, 0s delay	0.8	0.8	2.1	-0.7	0.6	-0.7	0.7	-1.0	1.5
Delay disc. indifference point, 16s delay	1.8	1.8	3.9	-1.1	1.0	-1.2	1.2	-1.4	2.0
Delay disc. indifference point, 2s delay	0.4	0.4	2.3	0.2	-0.2	-0.1	0.0	-0.2	1.5
Delay disc. indifference point, 24s delay	1.7	1.6	2.9	-1.1	1.0	-1.2	1.2	-1.3	1.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.2	0.1	-0.3	0.2	-0.4	0.4
Delay disc. indifference point, 8s delay	0.6	0.6	0.9	0.9	-1.0	0.8	-0.9	0.8	0.0
Delay discount exponential model param	0.3	0.3	1.4	0.1	-0.1	0.3	-0.2	0.4	-1.2
Delay discount hyperbolic model param	0.2	0.2	1.2	-0.0	0.1	0.2	-0.1	0.3	-1.1
Fecal boli incidents, locomotor time 1	3.2	3.5	4.4	2.1	-2.1	1.9	-2.0	1.7	-1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.5	0.5	-0.4	0.4	-0.3	0.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.2
Bouts of movement, locomotor time 1	0.7	0.8	3.3	-0.3	0.3	-0.7	0.5	-0.7	1.8
Total resting periods, locomotor time 1	0.6	0.7	3.5	-0.2	0.2	-0.6	0.4	-0.6	1.9
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.3	0.3	-0.3	0.2	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.5	0.4	-0.3	0.3	-0.3	-0.0
Vertical activity count, locomotor time 1	1.1	1.1	1.3	-1.1	1.1	-1.1	1.1	-1.1	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.2	0.2	-0.1	0.2	-0.1	-0.5
Bouts of movement, locomotor time 2	0.2	0.2	0.4	0.5	-0.6	0.3	-0.5	0.1	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.5	-0.6	0.4	-0.5	0.1	0.3
Rest time, locomotor task time 2	0.2	0.2	0.4	-0.5	0.6	-0.5	0.6	-0.3	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.1	0.3	-0.3	0.1	-0.2
Vertical activity count, locomotor time 2	0.2	0.3	0.9	-0.3	0.2	-0.4	0.3	-0.6	0.9
Weight adjusted by age	0.1	0.1	0.2	0.3	-0.3	0.4	-0.4	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	1.9	-1.1	1.1	-1.3	1.2	-0.9	1.4
Locomotion in novel chamber	0.3	0.4	0.6	0.7	-0.8	0.6	-0.7	0.7	-0.2
Locomotion in novel chamber post-restriction	0.1	0.2	0.9	0.1	-0.0	-0.2	0.1	0.2	0.9
Progressive ratio	0.3	0.3	0.6	0.7	-0.8	0.7	-0.5	0.1	-0.2
Food seeking constrained by brief footshock	3.2	3.9	4.4	-1.9	2.0	-2.0	2.1	-2.0	2.0
Seeking ratio, punishment vs. effort	1.7	2.1	2.7	-1.6	1.6	-1.6	1.5	-1.0	1.2
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.6	-0.6	0.5	-0.5	0.4	-0.3
Run reversals in cocaine runway, males	1.3	1.3	2.7	0.9	-0.8	1.0	-1.1	1.6	-1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.3	-0.3	0.2	-0.2	0.1	-0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	0.7	-0.7	0.7	-0.7	0.8	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.2	-0.3	0.2	-0.4	0.4
Cd content in liver	0.3	0.3	0.5	0.6	-0.6	0.6	-0.6	0.7	-0.4
Co content in liver	1.7	2.0	2.5	1.5	-1.4	1.5	-1.6	1.6	-1.0
Cu content in liver	1.0	1.2	1.6	-1.2	1.2	-1.2	1.3	-1.1	0.6
Fe content in liver	0.3	0.4	0.6	0.7	-0.8	0.6	-0.6	0.5	-0.1
K content in liver	0.6	0.6	0.7	-0.8	0.8	-0.7	0.8	-0.8	0.4
Mg content in liver	0.1	0.1	0.3	-0.2	0.2	-0.1	0.1	-0.1	-0.5
Mn content in liver	0.5	0.6	1.1	-0.9	0.9	-0.5	0.6	-0.4	-1.1
Na content in liver	5.2	5.5	6.2	-2.5	2.4	-2.4	2.4	-2.5	1.9
Rb content in liver	0.0	0.0	0.1	0.0	-0.1	-0.0	0.1	-0.1	-0.2
Se content in liver	4.6	5.5	12.1	1.9	-1.8	2.2	-2.1	2.2	-3.5
Sr content in liver	0.8	0.7	1.0	0.8	-0.7	0.9	-0.9	0.9	-1.0
Zn content in liver	0.3	0.3	0.4	0.6	-0.6	0.6	-0.6	0.6	-0.4