Hub : Genes

Ryr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020557	0.66	0.21	0.0e+00	0.11	0.12	0.12	0.11	2.7e-12	6.7e-13	7.2e-13	1.2e-12
2	Adipose	mRNA stability	ENSRNOG00000020557	0.16	0.12	2.2e-15	0.09	0.1	0.1	0.1	1.2e-10	5.9e-11	3.6e-11	6.3e-11
3	BLA	mRNA stability	ENSRNOG00000020557	0.05	0.05	1.9e-03	0.04	0.04	0.04	0	2.1e-03	2.5e-03	3.0e-03	1.8e-01
4	LHb	gene expression	ENSRNOG00000020557	0.19	0.13	2.4e-04	0.15	0.14	0.14	0.13	2.6e-04	2.8e-04	4.4e-04	5.7e-04
5	Liver	gene expression	ENSRNOG00000020557	0.11	0.07	5.8e-13	0.08	0.08	0.08	0.08	7.9e-09	5.3e-09	2.8e-09	2.2e-09
6	Liver	mRNA stability	ENSRNOG00000020557	0.06	0.04	5.4e-08	0.04	0.05	0.04	0.04	1.1e-05	3.9e-06	8.3e-06	1.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	0.2	0.5	0.8	-0.5	-0.7	-0.8	0.6	0.9	0.9
BMI without tail	0.1	0.3	0.5	0.5	0.7	0.3	-0.7	-0.5	-0.5
Body weight	2.8	11.8	12.8	3.4	3.5	3.3	-3.6	-3.5	-3.4
Epididymis fat weight	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.0	0.0	0.2
Glucose	0.3	0.4	0.7	-0.7	-0.6	-0.8	0.5	0.5	0.7
Heart weight	0.6	0.9	1.4	1.0	0.9	1.2	-1.0	-0.7	-0.9
Left kidney weight	2.7	7.6	8.9	3.0	2.7	3.0	-2.9	-2.3	-2.5
Right kidney weight	4.2	12.1	12.6	3.6	3.4	3.5	-3.5	-3.4	-3.4
Tail length	5.6	16.8	19.0	3.9	4.2	3.8	-4.1	-4.4	-4.2
Length with tail	8.2	30.2	33.7	5.2	5.6	5.3	-5.4	-5.8	-5.6
Length without tail	3.8	8.4	9.2	2.8	2.9	2.9	-2.8	-3.0	-3.0
Liver weight, left	0.1	0.1	0.4	-0.2	-0.3	-0.2	0.0	0.6	0.5
Liver weight, right	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	-0.0
Parametrial fat weight	0.7	1.3	2.0	-1.0	-1.2	-0.9	1.0	1.4	1.3
Retroperitoneal fat weight	1.1	3.6	4.8	-1.7	-2.0	-1.7	1.7	2.2	2.2
Intraocular pressure	0.0	0.1	0.2	-0.2	-0.1	-0.5	0.1	-0.2	0.1
Extensor digitorum longus weight	0.2	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9	0.9
Soleus weight	0.8	2.3	2.7	-1.6	-1.5	-1.7	1.6	1.2	1.4
Tibialis anterior weight	0.0	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	0.1
Tibia length	2.0	5.7	6.0	2.4	2.4	2.4	-2.4	-2.3	-2.4
Number of licking bursts	2.3	2.7	3.3	-1.5	-1.8	-1.5	1.7	1.8	1.7
Food consumed during 24 hour testing period	0.4	0.5	0.7	0.6	0.7	0.6	-0.4	-0.8	-0.7
Times rat made contact with spout	0.4	0.5	0.9	-0.5	-0.8	-0.6	0.5	0.9	0.9
Mean time between licks in bursts	0.1	0.2	0.3	0.4	0.3	0.6	-0.4	-0.3	-0.4
Mean num. licks in bursts	0.8	1.0	1.3	0.9	1.0	0.9	-1.1	-0.9	-1.0
Std. dev. time between licks in bursts	0.7	0.9	1.2	0.8	1.0	0.8	-1.0	-1.1	-1.0
Water consumed over 24 hours	0.7	0.8	1.2	1.0	0.9	1.0	-1.1	-0.6	-0.8
Indifference point 0 sec	0.3	0.4	0.5	0.6	0.7	0.7	-0.6	-0.6	-0.6
Indifference point AUC	0.3	0.4	0.6	-0.6	-0.6	-0.5	0.5	0.7	0.8
Indifference point function ln k	0.4	0.6	0.7	0.7	0.8	0.8	-0.6	-0.8	-0.8
Indifference point function log k	0.4	0.6	0.7	0.7	0.8	0.8	-0.6	-0.8	-0.8
Delay discounting total patch changes 0 sec	0.3	0.6	0.7	0.7	0.8	0.8	-0.7	-0.8	-0.7
Delay discounting total patch changes 12 sec	0.3	0.4	0.5	0.6	0.7	0.7	-0.6	-0.6	-0.5
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.3	0.4	0.5
Delay discounting total patch changes 24 sec	0.7	0.9	1.2	0.8	1.1	0.9	-0.8	-1.1	-0.9
Delay discounting total patch changes 6 sec	0.1	0.1	0.1	0.3	0.4	0.4	-0.4	-0.3	-0.2
Delay discounting time to switch 0 sec	1.2	1.8	2.1	-1.5	-1.3	-1.5	1.4	1.2	1.2
Delay discounting water rate 0 sec	0.4	0.7	0.9	-0.7	-0.9	-0.7	0.7	1.0	0.9
Delay discounting water rate 12 sec	0.8	1.2	1.4	1.2	1.1	1.1	-1.0	-1.1	-1.2
Delay discounting water rate 18 sec	0.6	0.8	1.4	-0.9	-1.0	-0.9	1.2	0.7	0.7
Delay discounting water rate 24 sec	0.3	0.4	0.6	0.7	0.5	0.7	-0.5	-0.4	-0.7
Delay discounting water rate 6 sec	0.1	0.1	0.2	0.3	0.3	0.3	-0.2	-0.5	-0.5
Locomotor activity	0.5	0.8	1.0	-0.8	-0.9	-0.8	0.7	1.0	1.0
Locomotor testing distance	1.0	1.6	1.9	-1.2	-1.3	-1.2	1.4	1.3	1.3
Locomotor testing rearing	1.6	2.6	3.4	-1.5	-1.7	-1.4	1.6	1.8	1.6
Light reinforcement 1	0.1	0.3	0.4	-0.5	-0.4	-0.6	0.5	0.3	0.6
Light reinforcement 2	7.1	9.4	10.1	-3.2	-3.0	-3.2	3.2	2.8	3.0
Reaction time number correct	0.0	0.1	0.2	0.2	-0.1	0.3	-0.3	0.4	0.1
Reaction time mean minus median	0.2	0.2	0.3	0.6	0.4	0.5	-0.4	-0.4	-0.5
Reaction time mean minus median AUC	0.3	0.3	0.5	0.7	0.5	0.7	-0.6	-0.4	-0.6
Reaction time num false alarms	0.9	1.2	1.5	-1.1	-1.1	-1.1	0.9	1.2	1.2
Reaction time num false alarms AUC	1.2	1.7	2.2	-1.3	-1.3	-1.2	1.1	1.4	1.5
Reaction time trials correct on left	0.0	0.1	0.2	0.2	-0.1	0.3	-0.3	0.4	0.1
Reaction time trials on left	0.0	0.1	0.2	0.2	-0.1	0.3	-0.2	0.4	0.1
Reaction time mean	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3	0.3	0.3
Reaction time mean AUC	0.2	0.3	0.3	-0.3	-0.6	-0.5	0.5	0.6	0.5
Median of all reaction times	0.2	0.3	0.4	-0.4	-0.6	-0.6	0.5	0.5	0.5
Reaction time omissions	0.3	0.3	0.6	-0.5	-0.7	-0.5	0.5	0.8	0.5
Reaction time false alarm rate	1.0	1.4	1.6	-1.3	-1.1	-1.3	1.2	1.0	1.2
Reaction time premature initiation rate	0.0	0.0	0.0	-0.0	0.1	0.0	0.1	-0.2	-0.2
Reaction time premature initiations	0.0	0.0	0.0	0.1	0.0	0.2	-0.0	0.1	-0.1
Std. dev. reaction times	0.1	0.1	0.2	0.4	0.2	0.4	-0.2	-0.2	-0.3
Reaction time trials completed	0.0	0.1	0.2	0.2	-0.1	0.3	-0.2	0.4	0.1
Reaction time trials AUC	0.1	0.1	0.4	0.1	-0.2	0.2	-0.1	0.6	0.3
Social response proportion	4.2	4.6	5.2	2.2	2.0	2.3	-2.1	-1.9	-2.2
Social responses	0.1	0.1	0.2	0.2	0.3	0.1	-0.3	-0.4	-0.4
Social time	0.6	0.8	1.6	0.7	0.8	0.5	-0.6	-1.3	-1.1
Conditioned locomotion	0.3	0.3	0.6	0.7	0.4	0.8	-0.7	0.0	-0.3
Cocaine response after cond. corrected	0.4	0.4	0.6	0.7	0.6	0.7	-0.8	-0.4	-0.6
Cocaine response after cond. not corrected	0.6	0.6	1.0	0.9	0.7	0.9	-1.0	-0.4	-0.6
Cocaine response before conditioning	1.3	1.6	2.5	1.5	1.2	1.6	-1.4	-0.8	-1.1
Saline control response	0.4	0.6	0.6	0.8	0.8	0.7	-0.8	-0.7	-0.7
Condit. Reinf. active minus inactive responses	4.2	5.2	5.8	2.3	2.3	2.4	-2.2	-2.1	-2.3
Condit. Reinf. active-inactive response ratio	2.6	2.7	3.6	1.9	1.5	1.9	-1.7	-1.2	-1.5
Condit. Reinf. active responses	4.9	6.8	7.1	2.6	2.6	2.7	-2.5	-2.6	-2.7
Condit. Reinf. inactive responses	1.7	2.1	3.1	1.2	1.5	1.3	-1.2	-1.7	-1.6
Condit. Reinf. lever presses	7.4	10.2	12.3	3.0	3.3	3.1	-2.8	-3.5	-3.4
Condit. Reinf. lever reinforcers received	5.7	8.1	8.7	2.9	2.9	2.9	-2.7	-2.7	-2.9
Pavlov. Cond. lever latency	3.5	4.8	5.8	-2.0	-2.3	-2.1	1.9	2.4	2.3
Pavlov. Cond. magazine entry latency	2.0	2.3	3.2	1.3	1.6	1.3	-1.3	-1.8	-1.6
Pavlov. Cond. change in total contacts	6.7	9.3	11.1	2.9	3.1	2.9	-2.7	-3.3	-3.3
Pavlov. Cond. index score	3.2	4.2	5.7	1.8	2.2	1.9	-1.7	-2.4	-2.2
Pavlov. Cond. latency score	3.1	3.9	5.2	1.8	2.1	1.8	-1.7	-2.3	-2.1
Pavlov. Cond. lever contacts	3.3	4.6	5.7	2.0	2.2	2.0	-1.9	-2.4	-2.3
Pavlov. Cond. magazine entry number	1.4	1.8	3.1	-1.1	-1.5	-1.0	1.0	1.8	1.5
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.2	-0.9	-1.3	-0.9	1.1	1.5	1.3
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.7	6.1	2.0	2.3	2.0	-1.9	-2.5	-2.3
Pavlov. Cond. response bias	3.8	5.2	6.4	2.2	2.4	2.2	-2.0	-2.5	-2.4
Conditioned reinforcement - actives	0.3	0.3	0.5	0.5	0.6	0.5	-0.7	-0.3	-0.4
Conditioned reinforcement - inactives	2.1	2.4	2.7	1.6	1.5	1.5	-1.6	-1.4	-1.6
Conditioned locomotion	1.3	1.5	2.2	-1.2	-1.2	-1.2	1.0	1.5	1.4
Intermittent access intake day 1-15 change	1.6	1.6	2.1	1.1	1.4	1.1	-1.3	-1.4	-1.2
Intermittent access intake escalation	1.2	1.2	1.6	0.9	1.2	0.8	-1.2	-1.2	-1.1
Intermittent access intake escalation 2	3.4	3.3	3.8	1.8	1.9	1.7	-2.0	-1.8	-1.8
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.6	0.5	1.0	0.4	-0.5	-1.3	-0.9
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.9	0.4	0.7	0.3	-0.3	-1.0	-0.6
Intermitt. access escalation Index	0.1	0.1	0.1	0.4	0.1	0.4	-0.2	-0.0	-0.3
Intermittent access day 1 total infusions	0.2	0.2	0.9	0.0	-0.5	0.1	0.3	0.9	0.4
Intermittent access day 15 total infusions	0.7	0.8	1.0	1.0	0.9	1.0	-0.9	-0.6	-0.9
Intermittent access terminal intake (last 3 days)	1.2	1.4	1.8	1.3	1.1	1.3	-1.2	-0.8	-1.1
Intermittent access total infusions	0.4	0.4	0.7	0.8	0.6	0.8	-0.6	-0.2	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.1	-0.2	0.0	0.1	0.6	0.3
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.0	0.3	0.2
Intermittent access total locomotion	0.4	0.5	0.7	-0.6	-0.6	-0.7	0.5	0.8	0.8
Intermittent access standard deviation	5.5	5.8	7.1	2.3	2.6	2.2	-2.2	-2.7	-2.5
Cocaine induced anxiety	0.1	0.1	0.2	-0.1	0.1	0.1	0.4	-0.4	-0.2
Post-drug Anxiety	0.4	0.4	1.0	-0.8	-0.4	-0.6	1.0	0.1	0.4
Baseline Anxiety	0.2	0.2	0.5	-0.2	-0.4	-0.3	0.1	0.7	0.6
Lifetime Intake	0.0	0.1	0.2	0.3	0.0	0.3	-0.1	0.4	0.0
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.0	0.2	-0.0	-0.0	-0.3	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	0.0	-0.2	0.1	-0.1	0.1
Progressive ratio test 1 active lever presses	1.3	1.3	1.9	1.4	1.0	1.3	-1.2	-0.6	-1.2
Progressive ratio test 1 breakpoint	1.8	1.9	2.6	1.6	1.2	1.6	-1.4	-0.8	-1.4
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.9	0.5	0.8	0.5	-0.4	-1.0	-0.7
Progressive ratio test 2 active lever presses	0.5	0.6	0.7	0.8	0.8	0.8	-0.7	-0.6	-0.8
Progressive ratio test 2 breakpoint	0.6	0.6	0.8	0.9	0.8	0.8	-0.8	-0.6	-0.8
Progressive ratio test 2 inactive lever presses	3.1	3.5	4.4	1.8	2.0	1.7	-1.6	-2.1	-2.0
Total sessions with >9 infusions	0.3	0.3	1.5	-0.0	-0.5	-0.1	-0.0	1.2	0.6
Short access day 1 total inactive lever presses	0.6	0.6	1.1	0.6	0.9	0.6	-0.5	-1.1	-0.9
Short access day 10 total inactive lever presses	0.5	0.5	1.6	0.3	0.8	0.3	-0.2	-1.3	-0.8
Short access day 1 total infusions	0.2	0.2	0.4	0.6	0.2	0.6	-0.5	0.2	-0.4
Short access day 10 total infusions	0.2	0.3	0.7	-0.2	-0.5	-0.2	0.5	0.8	0.5
Short access total infusions	0.4	0.4	1.2	-0.3	-0.6	-0.2	0.5	1.1	0.7
Short access day 1 locomotion	1.5	1.6	2.4	-1.2	-1.3	-1.1	1.0	1.5	1.5
Short access day 10 total locomotion	0.4	0.5	0.8	0.7	0.9	0.5	-0.7	-0.7	-0.5
Short access total locomotion	0.2	0.2	0.5	-0.3	-0.3	-0.3	0.2	0.7	0.7
Compulsive drug intake	0.4	0.4	0.7	0.5	0.6	0.5	-0.6	-0.9	-0.7
One hour access (0.3 mA shock)	1.4	1.7	2.1	1.2	1.4	1.1	-1.1	-1.4	-1.4
One hour access (shock baseline)	0.1	0.2	0.2	0.4	0.5	0.4	-0.4	-0.3	-0.4
Number of responses in last shaping day	2.2	2.3	2.9	1.7	1.3	1.7	-1.7	-1.1	-1.5
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3	0.3	0.2
Locomotion velocity, session 1	2.5	2.7	3.4	-1.7	-1.6	-1.7	1.8	1.5	1.5
Locomotion distance, session 1	0.9	1.1	1.3	1.1	1.1	1.0	-1.0	-1.1	-1.0
Locomotion velocity, session 2	0.4	0.5	0.6	-0.7	-0.7	-0.8	0.5	0.7	0.7
Locomotion distance, session 2	0.5	0.7	1.1	-0.7	-0.9	-0.8	0.7	1.0	1.0
Locomotion velocity, session 3	0.3	0.3	0.6	-0.4	-0.6	-0.3	0.5	0.8	0.6
Locomotion distance, session 3	6.0	6.5	7.0	2.6	2.6	2.6	-2.7	-2.4	-2.5
Stereotopy head waving bouts, day 3	0.8	1.0	1.9	-0.8	-1.1	-0.6	0.9	1.4	1.0
Stereotopy head waving duration, day 3	3.0	3.7	4.5	-1.9	-2.0	-1.7	1.8	2.1	1.9
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.0	-0.1	-0.0
Locomotion distance, session 7	0.1	0.1	0.1	0.3	0.3	0.2	-0.3	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.1	0.5	0.3
Stereotopy head waving duration, day 7	1.1	1.3	1.9	-1.1	-1.2	-1.0	1.0	1.4	1.2
Locomotion velocity, session 8	3.7	4.4	5.4	-1.9	-2.2	-1.9	2.0	2.3	2.1
Locomotion distance, session 8	0.4	0.5	0.6	-0.6	-0.8	-0.7	0.7	0.8	0.8
Degree of sensitization distance	3.5	3.5	4.0	-2.0	-1.9	-2.0	2.0	1.6	1.7
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.1	0.3	0.2
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.5	-0.6	-0.4	0.7	0.6	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.5	-0.6	-0.3	0.6	0.6	0.4
Condit. Reinf. active responses	1.2	1.4	1.7	-1.0	-1.2	-1.1	1.1	1.3	1.3
Condit. Reinf. inactive responses	0.7	0.8	1.2	-0.8	-0.9	-1.0	0.7	1.0	1.1
Incentive salience index mean	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.3	0.2
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	0.4	0.4	-0.5	-0.4	-0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.5	0.6	0.4	-0.5	-0.6	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.3	-0.5	-0.2	0.4	0.6	0.4
Total zone transitions, hab. session 1	0.5	0.7	1.0	1.0	0.9	0.8	-0.9	-0.8	-0.7
Total locomotion distance, hab. session 1	3.3	4.7	5.7	2.1	2.3	2.0	-2.0	-2.4	-2.2
Locomotion velocity, hab. session 1	1.4	2.1	2.7	1.4	1.5	1.3	-1.3	-1.7	-1.4
Time in familiar zone, hab. session 2	0.5	0.6	1.0	0.5	0.8	0.6	-0.5	-1.0	-0.9
Time in novel zone, hab. session 2	0.6	0.6	0.8	-0.7	-0.9	-0.7	0.7	0.9	0.9
Total zone transitions, hab. session 2	0.1	0.2	0.5	0.0	-0.4	-0.1	0.2	0.7	0.6
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.8	0.7	0.8	-0.7	-0.6	-0.6
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.8	0.6	0.8	-0.6	-0.4	-0.5
Novel to familiar place preference ratio	1.2	1.3	1.7	1.2	1.2	1.0	-1.3	-1.1	-1.0
Novelty place preference	1.1	1.1	1.5	1.1	1.1	1.0	-1.2	-1.0	-1.0
Time in novel zone, NPP test	0.6	0.7	0.9	0.9	0.9	0.7	-1.0	-0.8	-0.7
Total zone transitions, NPP test	0.1	0.2	0.3	-0.4	-0.3	-0.6	0.4	0.3	0.5
Total locomotion distance, NPP test	1.9	2.6	3.5	1.5	1.7	1.4	-1.4	-1.9	-1.7
Locomotion velocity, NPP test	2.3	3.3	4.3	1.7	1.9	1.6	-1.6	-2.1	-1.9
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.5	0.1	0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	-0.3	-0.4	-0.4	0.5	0.4	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	0.0	0.0
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	0.3	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	0.1	-0.0
Pavlov. Cond. lever contacts	0.7	0.8	1.0	1.0	0.9	0.9	-1.0	-0.8	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.3	0.2	-0.3	-0.4	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.3	-0.5	-0.3	0.3	0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	0.4	0.1	0.3	-0.3	0.2	0.0
Pavlov. Cond. response bias	0.1	0.1	0.1	0.4	0.2	0.3	-0.3	-0.2	-0.2
Bone: apparent density	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	0.3	0.3
Bone surface	0.2	0.4	0.6	0.5	0.7	0.5	-0.8	-0.7	-0.6
Bone volume	0.2	0.4	0.6	0.5	0.7	0.5	-0.8	-0.6	-0.6
Bone: connectivity density	0.5	0.8	1.1	-1.0	-0.8	-1.0	0.8	0.8	0.8
Bone: cortical apparent density	2.3	3.0	3.3	-1.6	-1.8	-1.7	1.7	1.8	1.8
Bone: cortical area	2.1	3.2	3.4	1.8	1.8	1.8	-1.8	-1.7	-1.8
Bone: cortical porosity	1.0	1.1	2.0	-0.8	-1.1	-0.7	0.7	1.4	1.2
Bone: cortical porosity	1.1	1.2	2.2	-0.9	-1.2	-0.8	0.8	1.5	1.2
Bone: cortical thickness	0.8	1.4	1.7	1.3	1.2	1.3	-1.1	-1.0	-1.2
Bone: cortical thickness	0.2	0.2	0.5	-0.2	-0.5	-0.2	0.3	0.7	0.5
Bone: cortical tissue density	2.8	3.6	3.9	-1.8	-2.0	-1.8	1.9	2.0	2.0
Bone: elastic displacement	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.1	0.2
Bone: elastic work	2.2	2.8	3.0	1.7	1.7	1.7	-1.6	-1.6	-1.7
Bone: endosteal estimation	1.3	2.9	3.4	1.6	1.8	1.5	-1.7	-1.8	-1.7
Bone: endosteal perimeter	1.3	2.6	3.5	1.4	1.7	1.4	-1.5	-1.9	-1.7
Bone: final force	1.7	2.8	2.9	1.7	1.7	1.7	-1.7	-1.6	-1.7
Bone: final moment	2.5	4.2	4.4	2.1	2.1	2.1	-2.0	-1.9	-2.0
Bone: marrow area	1.4	3.0	3.5	1.6	1.8	1.5	-1.7	-1.9	-1.8
Bone: maximum diameter	1.5	2.7	3.0	1.6	1.7	1.6	-1.7	-1.6	-1.6
Bone: maximum force	2.9	5.1	5.4	2.3	2.3	2.3	-2.2	-2.3	-2.3
Bone: maximum moment	3.9	6.8	7.2	2.6	2.7	2.6	-2.5	-2.6	-2.6
Bone: minimum diameter	5.8	10.7	11.0	3.3	3.3	3.3	-3.2	-3.2	-3.3
Bone: periosteal estimation	2.2	4.5	4.9	2.1	2.2	2.0	-2.1	-2.1	-2.1
Bone: periosteal perimeter	2.0	3.3	3.8	1.7	1.9	1.7	-1.7	-2.0	-1.9
Bone: post-yield work	0.9	1.2	1.8	0.9	1.2	0.9	-0.9	-1.3	-1.2
Bone: stiffness	1.5	2.3	2.5	1.5	1.6	1.5	-1.5	-1.5	-1.6
Bone: tissue strength	4.7	4.5	4.7	2.1	2.2	2.1	-2.1	-2.1	-2.1
Bone: trabecular number	0.1	0.1	0.2	0.2	0.5	0.2	-0.4	-0.4	-0.4
Bone: trabecular spacing	1.8	2.3	2.4	1.6	1.5	1.5	-1.5	-1.5	-1.5
Bone: trabecular thickness	0.3	0.3	0.6	-0.5	-0.6	-0.5	0.4	0.8	0.6
Bone: trabecular tissue density	2.7	3.8	4.0	-1.9	-2.0	-2.0	1.8	2.0	2.0
Breakpoint value in progressive ratio session	1.8	2.0	3.1	1.2	1.4	1.2	-1.1	-1.8	-1.7
Distance traveled before self-admin	1.8	1.9	2.5	1.6	1.3	1.6	-1.2	-1.2	-1.4
Distance traveled after self-admin	5.8	6.4	7.3	2.5	2.7	2.4	-2.2	-2.7	-2.6
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	0.6	1.0	0.5	-0.9	-1.0	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.1	-0.5	-0.1	0.2	0.7	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.3	0.2	0.3	-0.0	-0.5	-0.4
Extinction: sum of active levers before priming	1.3	1.3	1.7	1.1	1.3	1.0	-1.1	-1.3	-1.2
Active lever presses in extinction session 6	0.5	0.5	1.1	0.4	0.9	0.4	-0.4	-1.1	-0.8
Delta distance traveled before/after self-admin	0.9	1.0	2.1	0.6	1.1	0.5	-0.8	-1.5	-1.1
Delta ambulatory time before/after self-admin	1.4	1.5	2.2	1.1	1.4	0.9	-1.2	-1.5	-1.3
Time in closed arm before self-admin	0.2	0.2	0.5	-0.2	-0.7	-0.0	0.4	0.7	0.3
Time in closed arm after self-admin	0.2	0.2	0.4	0.3	0.4	0.3	-0.3	-0.6	-0.6
Time in open arm before self-admin	1.5	1.6	1.9	1.2	1.4	1.0	-1.3	-1.4	-1.2
Time in open arm after self-admin	0.8	0.9	1.4	1.1	0.9	1.1	-1.2	-0.5	-0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	-0.0	-0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.3	0.2	0.4	-0.3	0.3	0.1
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.4	0.4	0.4	-0.4	-0.5	-0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.1	-0.1	0.3	-0.4	0.3	0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	-0.0	0.2	-0.0	0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.3	0.3	0.2	-0.4	-0.5	-0.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.2	0.2	0.2
Ambulatory time before self-admin	1.0	1.0	1.4	1.2	0.9	1.2	-0.8	-0.9	-1.1
Ambulatory time after self-admin	6.1	6.8	7.9	2.6	2.7	2.5	-2.3	-2.8	-2.7
Total heroin consumption	1.6	1.9	2.2	1.5	1.4	1.5	-1.2	-1.4	-1.4
Area under the delay curve	0.1	0.2	0.6	-0.0	0.3	0.0	0.0	-0.8	-0.5
Delay disc. indifference point, 0s delay	0.6	0.6	1.3	0.6	0.9	0.5	-0.5	-1.2	-0.9
Delay disc. indifference point, 16s delay	1.6	1.6	2.9	1.0	1.4	1.0	-1.0	-1.7	-1.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	-0.2	0.3	-0.3	0.2	-0.8	-0.4
Delay disc. indifference point, 24s delay	1.6	1.5	2.4	1.1	1.3	1.1	-1.1	-1.5	-1.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.2	0.3	0.1	-0.2	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.7	0.7	1.1	-1.0	-0.8	-1.0	1.0	0.4	0.6
Delay discount exponential model param	0.2	0.2	0.6	-0.1	-0.4	-0.1	0.0	0.8	0.5
Delay discount hyperbolic model param	0.1	0.1	0.5	0.1	-0.2	0.1	-0.1	0.7	0.4
Fecal boli incidents, locomotor time 1	3.1	3.4	4.5	-2.0	-1.8	-2.1	1.8	1.6	1.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.4	0.5	-0.4	-0.3	-0.4
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0	0.1	0.1
Bouts of movement, locomotor time 1	0.5	0.5	1.2	0.3	0.8	0.4	-0.4	-1.1	-1.0
Total resting periods, locomotor time 1	0.4	0.4	1.0	0.2	0.7	0.3	-0.3	-1.0	-0.9
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.2	0.2	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	0.2	0.4	-0.5	-0.0	-0.1
Vertical activity count, locomotor time 1	1.2	1.3	1.8	1.1	1.1	1.1	-1.4	-1.0	-1.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	0.0	0.2	-0.2	0.0	0.0
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	-0.2	-0.5	0.7	-0.1	0.1
Total resting periods, locomotor time 2	0.2	0.2	0.5	-0.7	-0.3	-0.4	0.7	0.1	0.2
Rest time, locomotor task time 2	0.2	0.2	0.4	0.6	0.4	0.6	-0.5	-0.2	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.1	0.3	0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.5	0.3	0.5	0.2	-0.6	-0.7	-0.5
Weight adjusted by age	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.4	0.5	0.5
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	1.8	1.2	1.2	1.2	-1.4	-1.3	-1.3
Locomotion in novel chamber	0.3	0.4	0.7	-0.7	-0.5	-0.8	0.6	0.3	0.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	0.0	0.2	-0.0	-0.0	-0.4	-0.4
Progressive ratio	0.3	0.4	0.8	-0.7	-0.4	-0.9	0.6	0.1	0.6
Food seeking constrained by brief footshock	3.2	3.9	4.5	2.0	2.0	1.9	-1.8	-2.1	-2.1
Seeking ratio, punishment vs. effort	1.7	2.1	3.0	1.6	1.3	1.7	-1.4	-1.1	-1.5
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.6	-0.4	-0.6	0.7	0.2	0.5
Run reversals in cocaine runway, males	1.4	1.4	2.4	-1.0	-1.4	-0.8	1.1	1.6	1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.3	-0.1	-0.2	0.2	0.1	0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	-0.8	-0.7	-0.6	0.7	0.7	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.3	0.4	0.1	-0.3	-0.5	-0.3
Cd content in liver	0.3	0.3	0.5	-0.6	-0.6	-0.6	0.7	0.4	0.5
Co content in liver	2.0	2.3	2.4	-1.5	-1.5	-1.5	1.5	1.5	1.5
Cu content in liver	1.2	1.4	1.7	1.2	1.2	1.3	-1.1	-1.1	-1.1
Fe content in liver	0.3	0.3	0.6	-0.7	-0.5	-0.8	0.6	0.3	0.5
K content in liver	0.6	0.6	0.8	0.8	0.7	0.9	-0.8	-0.5	-0.6
Mg content in liver	0.0	0.0	0.1	0.2	-0.0	0.3	-0.2	0.3	0.1
Mn content in liver	0.3	0.4	0.8	0.8	0.3	0.9	-0.8	0.2	-0.2
Na content in liver	5.4	5.8	6.5	2.5	2.4	2.4	-2.5	-2.2	-2.3
Rb content in liver	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	-0.1	-0.1
Se content in liver	4.0	4.9	7.2	-1.9	-2.4	-2.0	1.8	2.7	2.5
Sr content in liver	0.8	0.8	1.1	-0.8	-0.9	-0.8	0.8	1.0	0.9
Zn content in liver	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.6	0.6