Rhog

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative polyA	ENSRNOT00000027641	0.05	0.04	3.3e-03	0.03	0.03	0.03	0.04	4.1e-04	5.8e-04	7.5e-04	2.7e-04
2	Brain	alternative polyA	ENSRNOT00000117183	0.06	0.04	1.2e-03	0.04	0.04	0.04	0.04	1.1e-04	1.5e-04	1.8e-04	6.4e-05
3	Brain	gene expression	ENSRNOG00000020393	0.03	0.02	3.8e-03	0.01	0.01	-0	0.01	3.7e-02	1.9e-02	4.9e-01	5.7e-02
4	IL	intron excision ratio	chr1:156619909:156627780	0.29	0.17	7.6e-03	0.02	-0.01	0.06	0.03	9.7e-02	7.5e-01	1.3e-02	6.1e-02
5	Liver	gene expression	ENSRNOG00000020393	0.21	0.1	0.0e+00	0.14	0.14	0.13	0.14	2.6e-15	1.7e-15	1.7e-14	3.3e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.8	2.5	6.4	0.9	-0.9	-2.5	2.2	-0.3
BMI without tail	0.9	1.8	4.9	-1.1	1.1	0.1	2.2	1.4
Body weight	0.3	1.4	2.3	-1.1	1.1	1.2	1.5	1.0
Epididymis fat weight	0.2	0.4	0.8	0.9	-0.9	0.0	0.5	-0.7
Glucose	0.2	0.3	1.4	0.2	-0.2	-1.2	0.4	0.1
Heart weight	1.2	1.7	2.8	-1.7	1.7	0.6	0.6	1.4
Left kidney weight	1.1	3.2	4.0	-2.0	2.0	0.8	2.0	1.9
Right kidney weight	0.7	1.9	2.5	-1.6	1.6	1.1	1.3	1.4
Tail length	4.6	14.0	23.1	-4.1	4.1	4.8	1.3	3.5
Length with tail	2.3	8.3	18.2	-3.0	3.0	4.3	0.7	2.3
Length without tail	0.1	0.2	0.4	0.4	-0.4	0.3	-0.6	-0.6
Liver weight, left	1.9	3.1	4.6	1.6	-1.6	1.6	-2.2	-1.9
Liver weight, right	1.7	2.8	6.3	0.9	-0.9	2.5	-2.0	-1.4
Parametrial fat weight	0.6	1.3	2.3	1.2	-1.2	-1.5	0.0	-1.0
Retroperitoneal fat weight	0.6	2.1	3.4	1.9	-1.9	0.6	-0.3	-1.8
Intraocular pressure	0.1	0.1	0.6	0.0	-0.0	-0.7	-0.3	0.0
Extensor digitorum longus weight	0.1	0.3	0.4	0.6	-0.6	-0.4	0.3	-0.6
Soleus weight	0.1	0.3	1.1	0.3	-0.3	1.0	-0.1	-0.5
Tibialis anterior weight	0.1	0.3	0.8	-0.4	0.4	0.9	0.2	0.3
Tibia length	0.3	0.9	1.5	-1.2	1.2	0.6	-0.1	1.1
Number of licking bursts	3.3	3.9	5.7	2.4	-2.4	-0.6	-1.5	-2.4
Food consumed during 24 hour testing period	2.0	2.3	3.8	-1.8	1.8	-0.1	1.3	2.0
Times rat made contact with spout	0.3	0.4	0.8	0.5	-0.5	0.4	-0.9	-0.6
Mean time between licks in bursts	5.6	7.8	11.0	-3.1	3.1	3.3	1.1	2.7
Mean num. licks in bursts	2.5	3.0	4.5	-2.1	2.1	0.8	1.1	2.1
Std. dev. time between licks in bursts	1.3	1.6	4.2	-1.2	1.2	2.0	0.4	1.0
Water consumed over 24 hours	0.6	0.7	0.9	0.9	-0.9	-0.3	-0.8	-0.9
Indifference point 0 sec	2.2	3.5	4.8	-2.1	2.1	0.3	1.9	2.2
Indifference point AUC	0.4	0.5	0.7	-0.8	0.8	0.7	0.4	0.7
Indifference point function ln k	0.0	0.1	0.1	-0.1	0.1	-0.3	-0.1	0.3
Indifference point function log k	0.0	0.1	0.1	-0.1	0.1	-0.3	-0.1	0.3
Delay discounting total patch changes 0 sec	1.9	3.1	4.1	-2.0	2.0	0.1	2.0	2.0
Delay discounting total patch changes 12 sec	1.1	1.5	2.1	-1.4	1.4	0.9	1.0	1.3
Delay discounting total patch changes 18 sec	0.9	1.2	1.6	-1.3	1.3	0.3	1.1	1.2
Delay discounting total patch changes 24 sec	1.6	2.0	2.9	-1.7	1.7	1.0	1.1	1.4
Delay discounting total patch changes 6 sec	1.3	1.9	2.9	-1.7	1.7	0.3	1.3	1.4
Delay discounting time to switch 0 sec	3.5	5.4	7.4	2.7	-2.7	-0.7	-2.1	-2.7
Delay discounting water rate 0 sec	2.7	4.3	5.8	-2.4	2.4	0.6	1.9	2.4
Delay discounting water rate 12 sec	2.6	3.9	8.8	-1.5	1.5	-1.4	3.0	2.0
Delay discounting water rate 18 sec	3.1	4.1	6.3	-2.1	2.1	-0.1	2.5	2.4
Delay discounting water rate 24 sec	0.7	0.9	2.5	-0.4	0.4	-1.1	1.6	0.8
Delay discounting water rate 6 sec	0.9	1.3	2.4	-0.9	0.9	-1.0	1.5	1.2
Locomotor activity	0.5	0.8	1.9	-0.8	0.8	-0.2	1.4	1.0
Locomotor testing distance	1.7	2.8	4.5	-1.7	1.7	0.0	2.1	2.0
Locomotor testing rearing	0.6	0.9	1.2	-0.9	0.9	0.7	1.0	1.1
Light reinforcement 1	1.9	3.6	4.8	2.2	-2.2	-2.1	-0.5	-1.9
Light reinforcement 2	1.7	2.2	8.3	0.7	-0.7	-2.9	1.4	-0.1
Reaction time number correct	0.1	0.1	0.4	0.1	-0.1	-0.6	0.3	0.1
Reaction time mean minus median	0.4	0.5	0.6	-0.7	0.7	0.6	0.8	0.7
Reaction time mean minus median AUC	0.3	0.4	0.6	-0.6	0.6	0.3	0.7	0.6
Reaction time num false alarms	2.0	2.7	4.1	1.7	-1.7	0.5	-1.8	-2.0
Reaction time num false alarms AUC	1.8	2.6	3.9	1.8	-1.8	0.2	-1.7	-2.0
Reaction time trials correct on left	0.1	0.1	0.4	0.1	-0.1	-0.6	0.3	0.1
Reaction time trials on left	0.1	0.1	0.5	0.1	-0.1	-0.7	0.4	0.0
Reaction time mean	1.5	2.0	3.0	1.6	-1.6	0.7	-1.3	-1.7
Reaction time mean AUC	1.8	2.4	3.7	1.7	-1.7	0.6	-1.5	-1.9
Median of all reaction times	2.4	3.3	5.0	2.1	-2.1	0.5	-1.6	-2.2
Reaction time omissions	0.7	1.0	1.6	1.3	-1.3	-0.7	0.1	-1.1
Reaction time false alarm rate	1.7	2.4	3.7	1.7	-1.7	0.2	-1.5	-1.9
Reaction time premature initiation rate	1.7	2.2	2.4	-1.6	1.6	1.3	1.5	1.5
Reaction time premature initiations	1.0	1.4	2.4	-1.2	1.2	0.6	1.6	1.3
Std. dev. reaction times	0.4	0.5	2.0	0.1	-0.1	1.4	-0.5	-0.4
Reaction time trials completed	0.1	0.1	0.5	0.1	-0.1	-0.7	0.4	0.0
Reaction time trials AUC	0.1	0.1	0.3	0.0	-0.0	-0.5	0.4	0.1
Social response proportion	0.1	0.1	0.1	0.3	-0.3	0.2	0.2	-0.4
Social responses	0.2	0.3	0.7	0.4	-0.4	0.8	-0.1	-0.5
Social time	2.3	3.0	4.5	2.1	-2.1	-1.0	-1.3	-1.9
Conditioned locomotion	0.4	0.5	0.6	0.6	-0.6	0.7	-0.7	-0.8
Cocaine response after cond. corrected	0.9	1.0	1.7	1.2	-1.2	-0.3	-0.6	-1.3
Cocaine response after cond. not corrected	0.5	0.6	0.8	0.9	-0.9	-0.9	0.0	-0.8
Cocaine response before conditioning	1.2	1.5	2.1	-1.0	1.0	-1.1	1.4	1.4
Saline control response	2.2	2.9	4.3	-1.9	1.9	2.1	0.4	1.7
Condit. Reinf. active minus inactive responses	6.5	8.0	11.1	-3.3	3.3	1.9	1.9	3.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.0	-1.3	1.3	0.3	0.9	1.4
Condit. Reinf. active responses	8.1	11.3	15.2	-3.9	3.9	2.5	2.3	3.8
Condit. Reinf. inactive responses	4.6	5.7	7.5	-2.7	2.7	2.1	1.5	2.6
Condit. Reinf. lever presses	12.9	17.7	25.3	-4.9	4.9	1.6	3.6	5.0
Condit. Reinf. lever reinforcers received	8.6	12.1	16.7	-4.1	4.1	2.4	2.3	4.0
Pavlov. Cond. lever latency	15.4	21.1	30.0	5.2	-5.2	-1.0	-4.6	-5.5
Pavlov. Cond. magazine entry latency	5.1	5.9	12.0	-2.1	2.1	-1.3	3.5	2.6
Pavlov. Cond. change in total contacts	13.5	18.8	27.2	-4.9	4.9	0.7	4.3	5.2
Pavlov. Cond. index score	12.1	15.8	22.4	-4.3	4.3	0.3	4.4	4.7
Pavlov. Cond. latency score	11.1	14.0	19.7	-4.0	4.0	-0.0	4.3	4.4
Pavlov. Cond. lever contacts	15.7	21.8	31.0	-5.3	5.3	1.3	4.4	5.6
Pavlov. Cond. magazine entry number	7.3	9.0	13.7	3.0	-3.0	0.7	-3.7	-3.5
Pavlov. Cond. intertrial magazine entries	0.8	1.0	3.3	-0.5	0.5	1.8	-1.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	11.9	15.4	21.7	-4.3	4.3	0.4	4.3	4.7
Pavlov. Cond. response bias	16.4	22.6	32.2	-5.3	5.3	0.8	4.8	5.7
Conditioned reinforcement - actives	0.1	0.1	0.1	-0.2	0.2	-0.3	0.1	0.4
Conditioned reinforcement - inactives	0.4	0.5	0.9	0.4	-0.4	0.9	-0.9	-0.7
Conditioned locomotion	0.8	1.0	1.4	-0.9	0.9	-0.9	1.0	1.2
Intermittent access intake day 1-15 change	1.3	1.3	2.6	-0.8	0.8	-1.2	1.6	1.0
Intermittent access intake escalation	1.0	1.0	2.0	-0.6	0.6	-1.3	1.4	0.9
Intermittent access intake escalation 2	0.3	0.3	0.7	0.4	-0.4	-0.8	0.8	-0.0
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.0	1.1	-1.1	0.8	-1.4	-1.3
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.9	-1.0	0.9	0.6	0.2	0.7
Intermitt. access escalation Index	0.1	0.1	0.5	-0.1	0.1	0.7	-0.3	-0.0
Intermittent access day 1 total infusions	0.5	0.6	0.8	-0.8	0.8	0.9	-0.1	0.8
Intermittent access day 15 total infusions	0.4	0.5	0.7	-0.8	0.8	0.1	0.6	0.8
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	-0.6	0.6	0.2	0.6	0.7
Intermittent access total infusions	0.1	0.1	0.2	-0.3	0.3	0.4	0.1	0.5
Intermittent access day 1 locomotion	0.3	0.3	1.0	0.0	-0.0	0.5	-1.0	-0.3
Intermittent access day 15 total locomotion	0.4	0.4	0.5	-0.7	0.7	-0.6	0.4	0.7
Intermittent access total locomotion	0.2	0.2	0.4	-0.6	0.6	0.1	0.3	0.6
Intermittent access standard deviation	0.3	0.3	0.7	0.5	-0.5	-0.8	0.6	-0.2
Cocaine induced anxiety	2.7	3.1	4.5	1.9	-1.9	0.5	-1.9	-2.1
Post-drug Anxiety	0.9	1.0	3.0	0.2	-0.2	1.7	-1.3	-0.6
Baseline Anxiety	2.2	2.3	3.4	-1.8	1.8	1.4	0.3	1.6
Lifetime Intake	0.4	0.4	0.8	-0.7	0.7	0.3	0.5	0.9
Incentive Sensitization - Responses	0.3	0.3	0.6	-0.6	0.6	0.8	-0.0	0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.4	0.4	0.4	0.1	0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.0	0.0	0.1	-0.3	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.0	0.0	0.2	-0.3	0.0
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3	0.0
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	-0.1	0.1	0.6	-0.6	0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.3	0.3	0.7	-0.5	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	0.2
Total sessions with >9 infusions	1.8	2.0	3.0	-1.3	1.3	-0.9	1.6	1.7
Short access day 1 total inactive lever presses	0.6	0.7	1.8	0.5	-0.5	0.8	-1.3	-0.8
Short access day 10 total inactive lever presses	0.5	0.6	0.9	0.9	-0.9	-0.2	-0.6	-1.0
Short access day 1 total infusions	1.0	1.0	1.6	-1.2	1.2	0.5	0.8	1.3
Short access day 10 total infusions	0.7	0.7	1.1	-1.0	1.0	0.5	0.6	1.1
Short access total infusions	0.8	0.9	1.4	-1.1	1.1	0.4	0.8	1.2
Short access day 1 locomotion	0.4	0.4	1.1	-0.3	0.3	-1.0	0.6	0.7
Short access day 10 total locomotion	0.2	0.2	0.6	0.3	-0.3	-0.8	0.5	-0.1
Short access total locomotion	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.0	-0.1
Compulsive drug intake	0.2	0.2	0.3	0.3	-0.3	-0.6	-0.4	-0.4
One hour access (0.3 mA shock)	0.7	0.8	1.9	-0.6	0.6	-0.6	1.4	0.9
One hour access (shock baseline)	0.5	0.6	1.0	-0.7	0.7	0.3	1.0	0.9
Number of responses in last shaping day	0.5	0.5	1.1	0.2	-0.2	1.1	-1.0	-0.4
Context. condit. distance diff. score	2.8	3.4	5.2	-2.1	2.1	-0.1	1.8	2.3
Locomotion velocity, session 1	0.9	1.0	3.1	0.9	-0.9	-1.8	0.4	-0.6
Locomotion distance, session 1	0.7	0.9	1.9	-0.5	0.5	-1.2	1.4	0.9
Locomotion velocity, session 2	0.5	0.6	2.0	0.1	-0.1	-1.4	1.0	0.2
Locomotion distance, session 2	0.7	1.0	2.5	-0.3	0.3	-1.4	1.6	0.7
Locomotion velocity, session 3	0.4	0.4	0.8	-0.8	0.8	0.0	0.3	0.9
Locomotion distance, session 3	0.5	0.6	1.0	-0.9	0.9	-0.3	0.4	1.0
Stereotopy head waving bouts, day 3	0.2	0.2	1.0	-0.1	0.1	1.0	-0.4	-0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.6	0.6	-0.1	0.5	0.6
Locomotion velocity, session 7	0.4	0.4	1.5	0.4	-0.4	-1.2	0.3	-0.2
Locomotion distance, session 7	0.1	0.2	0.2	0.5	-0.5	-0.1	-0.3	-0.5
Stereotopy head waving bouts, day 7	2.3	2.6	4.1	-2.0	2.0	0.3	0.9	2.0
Stereotopy head waving duration, day 7	2.4	2.9	4.6	-2.1	2.1	0.1	1.2	2.1
Locomotion velocity, session 8	1.0	1.2	1.9	-1.4	1.4	0.2	0.6	1.4
Locomotion distance, session 8	2.5	3.7	5.8	-1.9	1.9	-0.6	2.4	2.3
Degree of sensitization distance	0.3	0.3	1.0	0.3	-0.3	1.0	-0.1	-0.5
Degree of sensitization stereotypy	4.5	4.9	7.7	-2.7	2.7	0.4	1.4	2.8
Condit. Reinf. active minus inactive responses	1.1	1.2	3.0	-1.1	1.1	1.7	-0.1	0.8
Condit. Reinf. active-inactive response ratio	1.9	2.0	5.5	-1.3	1.3	2.3	-0.5	0.9
Condit. Reinf. active responses	0.5	0.6	2.0	-0.4	0.4	1.4	-0.7	0.1
Condit. Reinf. inactive responses	0.3	0.3	0.5	0.6	-0.6	-0.4	-0.3	-0.7
Incentive salience index mean	0.6	0.7	2.2	-0.7	0.7	1.5	-0.5	0.4
Condit. Reinf. lever presses	0.1	0.1	0.3	0.1	-0.1	0.2	-0.5	-0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.5	0.5	-0.0	0.8	0.6
Time in novel zone, hab. session 1	0.4	0.4	0.9	0.5	-0.5	0.6	-0.9	-0.6
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.3	0.3	-0.7	0.1	0.4
Total locomotion distance, hab. session 1	0.2	0.3	1.5	-0.1	0.1	1.2	-0.1	-0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.8	0.1	-0.1	0.9	0.1	-0.2
Time in familiar zone, hab. session 2	2.9	3.0	4.0	-2.0	2.0	1.6	1.1	1.8
Time in novel zone, hab. session 2	1.7	1.7	3.7	1.4	-1.4	-1.9	-0.1	-1.1
Total zone transitions, hab. session 2	2.6	3.3	4.6	-2.2	2.2	-0.2	1.7	2.1
Total locomotion distance, hab. session 2	1.1	1.5	1.7	-1.2	1.2	1.3	1.2	1.0
Locomotion velocity, hab. session 2	0.9	1.3	1.8	-1.1	1.1	1.4	1.1	0.9
Novel to familiar place preference ratio	1.1	1.2	4.4	-0.4	0.4	2.1	-1.0	0.1
Novelty place preference	1.0	1.0	4.0	-0.4	0.4	2.0	-0.9	0.2
Time in novel zone, NPP test	1.2	1.2	4.5	-0.6	0.6	2.1	-0.8	0.4
Total zone transitions, NPP test	0.5	0.8	2.6	-0.1	0.1	-1.6	1.0	0.4
Total locomotion distance, NPP test	0.3	0.4	1.5	0.3	-0.3	-0.5	1.2	-0.2
Locomotion velocity, NPP test	0.4	0.6	1.1	0.7	-0.7	-0.8	1.0	-0.5
Pavlov. Cond. lever latency	0.5	0.6	0.8	0.9	-0.9	-0.9	0.2	-0.8
Pavlov. Cond. magazine entry latency	2.5	3.2	4.6	-2.1	2.1	0.8	1.5	2.2
Pavlov. Cond. change in total contacts	1.1	1.2	2.1	-1.2	1.2	1.5	-0.5	0.9
Pavlov. Cond. index score	1.5	1.9	2.9	-1.7	1.7	0.9	0.6	1.7
Pavlov. Cond. latency score	1.3	1.7	2.5	-1.6	1.6	1.0	0.4	1.5
Pavlov. Cond. lever contacts	0.5	0.5	0.8	-0.9	0.9	0.7	-0.0	0.8
Pavlov. Cond. magazine entry number	2.0	2.5	3.8	1.9	-1.9	-0.6	-1.1	-2.0
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.7	1.0	-1.0	-0.0	-1.3	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.3	-1.5	1.5	0.8	0.5	1.5
Pavlov. Cond. response bias	0.7	0.9	1.3	-1.1	1.1	0.6	0.6	1.1
Bone: apparent density	0.3	0.5	1.1	0.6	-0.6	-0.3	-1.0	-0.6
Bone surface	0.4	0.7	1.0	-0.9	0.9	1.0	-0.5	0.8
Bone volume	0.2	0.4	0.8	-0.6	0.6	0.9	-0.5	0.5
Bone: connectivity density	0.4	0.7	2.4	0.7	-0.7	-1.5	-0.3	-0.4
Bone: cortical apparent density	0.9	1.1	1.9	1.2	-1.2	0.5	-0.9	-1.4
Bone: cortical area	0.2	0.3	0.7	-0.6	0.6	0.9	0.1	0.5
Bone: cortical porosity	0.2	0.2	0.5	-0.3	0.3	0.5	-0.7	0.2
Bone: cortical porosity	0.2	0.3	0.6	-0.4	0.4	0.6	-0.8	0.2
Bone: cortical thickness	0.2	0.4	0.7	0.7	-0.7	-0.8	0.1	-0.5
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1	0.0	0.2	0.1
Bone: cortical tissue density	0.9	1.1	1.9	1.2	-1.2	0.5	-0.9	-1.4
Bone: elastic displacement	1.7	1.9	2.5	1.6	-1.6	-1.6	-0.4	-1.4
Bone: elastic work	2.7	3.5	6.3	2.0	-2.0	-2.5	-0.3	-1.7
Bone: endosteal estimation	0.9	2.0	3.8	-1.5	1.5	2.0	0.1	1.2
Bone: endosteal perimeter	1.3	2.7	3.5	-1.9	1.9	1.9	0.4	1.6
Bone: final force	0.7	1.1	2.4	0.4	-0.4	1.6	-1.5	-0.7
Bone: final moment	0.5	0.8	2.2	0.2	-0.2	1.5	-1.2	-0.5
Bone: marrow area	0.8	1.6	3.6	-1.3	1.3	1.9	-0.1	1.0
Bone: maximum diameter	1.6	2.9	3.9	-2.0	2.0	1.7	0.6	1.8
Bone: maximum force	0.4	0.6	1.5	0.2	-0.2	1.2	-1.2	-0.4
Bone: maximum moment	0.2	0.4	1.0	-0.1	0.1	1.0	-0.9	-0.1
Bone: minimum diameter	0.6	1.2	3.8	-0.9	0.9	1.9	-0.2	0.7
Bone: periosteal estimation	0.6	1.2	2.3	-1.2	1.2	1.5	0.0	1.0
Bone: periosteal perimeter	0.9	1.5	1.9	-1.4	1.4	1.2	0.6	1.3
Bone: post-yield work	0.1	0.1	0.2	-0.3	0.3	0.1	0.3	0.4
Bone: stiffness	1.3	2.0	5.4	0.4	-0.4	2.3	-1.9	-0.9
Bone: tissue strength	1.0	1.0	3.8	0.7	-0.7	-2.0	0.4	-0.3
Bone: trabecular number	1.3	1.9	2.6	1.6	-1.6	-1.3	-1.0	-1.4
Bone: trabecular spacing	0.9	1.2	2.7	-0.8	0.8	-0.9	1.6	1.0
Bone: trabecular thickness	0.9	1.1	3.1	0.1	-0.1	1.8	-1.5	-0.4
Bone: trabecular tissue density	2.0	2.9	7.1	0.6	-0.6	2.7	-2.2	-1.2
Breakpoint value in progressive ratio session	0.7	0.8	1.6	1.0	-1.0	-1.3	0.5	-0.4
Distance traveled before self-admin	0.5	0.5	0.9	0.8	-0.8	-0.9	-0.1	-0.7
Distance traveled after self-admin	0.3	0.4	0.9	-0.2	0.2	-0.9	0.8	0.5
Delta time in closed arm before/after self-admin	0.6	0.6	0.8	0.7	-0.7	0.9	-0.7	-0.9
Delta time in open arm before/after self-admin	2.4	2.3	3.6	-1.9	1.9	1.3	0.4	1.6
Diff in mean of infusions in LGA sessions	1.8	2.1	3.8	1.1	-1.1	1.3	-2.0	-1.5
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.6	-0.6	-0.3	-0.3	-0.5
Active lever presses in extinction session 6	1.3	1.2	1.8	-1.2	1.2	-0.7	1.0	1.3
Delta distance traveled before/after self-admin	1.5	1.7	2.2	-1.4	1.4	1.3	0.4	1.5
Delta ambulatory time before/after self-admin	1.1	1.2	1.9	-1.3	1.3	0.8	0.4	1.4
Time in closed arm before self-admin	2.1	2.4	3.7	-1.5	1.5	-0.6	1.9	1.8
Time in closed arm after self-admin	0.3	0.4	0.5	0.7	-0.7	-0.1	-0.6	-0.7
Time in open arm before self-admin	4.8	5.1	7.2	2.7	-2.7	-0.9	-1.7	-2.7
Time in open arm after self-admin	0.1	0.1	0.5	-0.1	0.1	0.7	-0.2	-0.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.1	0.1	-0.6	0.9	0.4
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.6	-0.8	0.8	0.3	0.4	0.7
Time to tail flick, vehicle, after self-admin	0.8	0.8	1.7	-1.1	1.1	0.4	0.3	1.3
Time to tail flick, test, before self-admin	2.1	2.1	3.3	-1.8	1.8	1.4	0.2	1.4
Time to tail flick, test, after self-admin	3.0	3.0	5.7	-1.9	1.9	2.4	0.0	1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.1	0.1	-0.3	-0.0	0.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	-0.2	0.0	0.1	-0.3
Ambulatory time before self-admin	0.8	0.9	1.2	1.1	-1.1	-0.9	-0.4	-1.0
Ambulatory time after self-admin	0.1	0.1	0.3	-0.3	0.3	-0.4	0.2	0.6
Total heroin consumption	0.8	0.9	2.1	-0.7	0.7	-0.4	1.4	1.1
Area under the delay curve	0.8	0.9	1.9	0.8	-0.8	0.4	-1.4	-1.0
Delay disc. indifference point, 0s delay	0.5	0.5	0.7	-0.9	0.9	0.2	0.7	0.8
Delay disc. indifference point, 16s delay	1.1	1.1	3.1	0.5	-0.5	0.9	-1.8	-1.0
Delay disc. indifference point, 2s delay	0.4	0.5	1.0	-0.7	0.7	1.0	-0.4	0.4
Delay disc. indifference point, 24s delay	1.8	1.7	2.9	1.3	-1.3	0.4	-1.7	-1.6
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	-0.9	0.9	1.1	0.2	0.6
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	0.8	-0.8	-0.2	-0.8	-0.8
Delay discount exponential model param	0.9	1.0	1.8	-0.9	0.9	-0.1	1.3	1.1
Delay discount hyperbolic model param	0.6	0.6	1.4	-0.7	0.7	-0.3	1.2	0.9
Fecal boli incidents, locomotor time 1	2.0	2.2	3.2	1.6	-1.6	-0.2	-1.8	-1.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	0.4	-0.0	0.5	0.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.8	-0.9	0.9	0.7	-0.1	0.7
Bouts of movement, locomotor time 1	0.7	0.8	1.6	-0.7	0.7	1.3	-1.2	0.1
Total resting periods, locomotor time 1	0.4	0.4	1.7	-0.1	0.1	0.6	-1.3	-0.3
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.1	0.1	0.6	-0.6	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.0	-0.0	-0.2	0.6	0.1
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.2	-0.2	0.2	-0.1	-0.2
Time >=10cm from walls, locomotor time 2	2.6	2.7	3.8	-1.9	1.9	1.8	0.5	1.6
Bouts of movement, locomotor time 2	1.2	1.3	4.1	-0.2	0.2	2.0	-1.6	-0.3
Total resting periods, locomotor time 2	1.2	1.2	3.0	0.3	-0.3	1.6	-1.7	-0.7
Rest time, locomotor task time 2	2.2	2.6	3.8	2.0	-2.0	-1.1	-0.8	-1.9
Distance moved, locomotor task time 2	2.4	2.8	3.8	-1.9	1.9	0.8	1.4	1.9
Vertical activity count, locomotor time 2	0.3	0.4	1.1	-0.5	0.5	1.1	-0.1	0.4
Weight adjusted by age	1.6	1.8	2.5	-1.6	1.6	0.8	1.2	1.4
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	2.6	1.6	-1.6	-1.1	-1.2	-1.6
Locomotion in novel chamber	0.5	0.7	2.1	0.7	-0.7	-1.5	0.1	-0.4
Locomotion in novel chamber post-restriction	0.3	0.3	0.6	-0.5	0.5	-0.7	0.3	0.8
Progressive ratio	0.2	0.2	0.6	-0.3	0.3	-0.8	0.5	0.2
Food seeking constrained by brief footshock	2.0	2.4	3.1	-1.8	1.8	1.4	1.2	1.6
Seeking ratio, punishment vs. effort	0.6	0.7	1.7	-0.7	0.7	1.3	0.4	0.8
Run reversals in cocaine runway, females	0.5	0.5	1.3	-0.5	0.5	0.5	1.2	0.7
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.5	-0.5	-0.2	-0.9	-0.8
Latency to leave start box in cocaine runway	1.4	1.5	2.4	1.5	-1.5	-0.3	-1.0	-1.4
Latency to leave start box in cocaine runway, F	0.8	0.9	1.2	1.1	-1.1	0.5	-0.8	-1.1
Latency to leave start box in cocaine runway, M	1.3	1.2	1.7	1.3	-1.3	-1.0	-0.9	-1.0
Cd content in liver	0.7	0.7	1.0	1.0	-1.0	-0.1	-0.8	-1.0
Co content in liver	2.4	2.9	5.7	-1.8	1.8	2.4	-0.6	1.3
Cu content in liver	1.1	1.4	3.1	-1.2	1.2	1.7	-0.3	0.9
Fe content in liver	0.5	0.6	1.5	0.0	-0.0	1.1	-1.2	-0.3
K content in liver	0.4	0.4	0.7	0.8	-0.8	-0.0	-0.6	-0.8
Mg content in liver	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2	0.1
Mn content in liver	2.3	2.6	3.6	1.9	-1.9	-1.6	-0.9	-1.6
Na content in liver	0.2	0.2	0.4	-0.5	0.5	-0.0	-0.6	0.4
Rb content in liver	0.6	0.8	1.0	-0.9	0.9	1.0	-1.0	0.6
Se content in liver	4.8	5.8	7.2	2.7	-2.7	-0.8	-2.6	-2.7
Sr content in liver	1.2	1.1	2.7	-0.1	0.1	-1.6	1.6	0.6
Zn content in liver	2.6	2.8	4.3	-1.7	1.7	-0.4	2.1	2.0