Hub : Genes

P4htm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020249	0.06	0.04	8.8e-03	0.02	0.01	0.01	0.01	5.5e-03	1.9e-02	2.8e-02	7.1e-02
2	BLA	gene expression	ENSRNOG00000020249	0.07	0.07	4.9e-03	0.01	0.02	0.04	0.02	7.7e-02	3.6e-02	2.7e-03	4.0e-02
3	Liver	gene expression	ENSRNOG00000020249	0.07	0.05	1.4e-03	0.01	0.02	0.04	0.02	1.1e-02	1.5e-03	7.0e-05	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	1.2	3.9	9.6	-0.8	-1.2	3.1
BMI without tail	1.6	3.4	7.1	-1.8	-0.0	2.7
Body weight	4.1	17.4	31.8	-4.5	0.3	5.6
Epididymis fat weight	0.1	0.3	0.6	-0.3	0.4	0.7
Glucose	1.5	2.3	5.0	-0.6	2.2	-1.3
Heart weight	3.9	5.5	11.9	-1.9	-1.1	3.4
Left kidney weight	0.8	2.3	3.1	-1.3	1.8	1.5
Right kidney weight	0.7	2.0	5.7	-0.5	2.4	0.2
Tail length	3.6	10.9	20.3	-4.5	1.9	3.0
Length with tail	4.6	16.8	29.7	-5.5	2.1	4.1
Length without tail	3.0	6.5	10.4	-3.2	1.0	2.9
Liver weight, left	0.4	0.7	1.0	-0.6	0.8	-1.0
Liver weight, right	1.6	2.6	5.2	-1.6	2.3	0.3
Parametrial fat weight	0.8	1.6	2.3	-1.4	1.5	0.6
Retroperitoneal fat weight	0.3	1.1	1.4	-0.9	1.2	1.0
Intraocular pressure	1.0	1.5	2.8	-1.7	0.9	-0.9
Extensor digitorum longus weight	0.2	0.8	1.7	0.8	-1.3	0.3
Soleus weight	2.4	6.9	10.4	-3.2	0.6	3.2
Tibialis anterior weight	0.1	0.2	0.6	0.1	-0.4	0.8
Tibia length	4.0	11.2	16.1	-4.0	2.0	3.7
Number of licking bursts	1.1	1.3	3.5	0.4	-1.9	0.4
Food consumed during 24 hour testing period	1.6	1.9	4.3	-1.2	-0.1	2.1
Times rat made contact with spout	0.4	0.5	0.8	-0.9	-0.2	0.8
Mean time between licks in bursts	0.6	0.8	2.2	1.5	-0.4	-0.2
Mean num. licks in bursts	1.4	1.7	4.2	-1.0	2.1	-0.1
Std. dev. time between licks in bursts	3.1	3.7	6.0	2.4	-2.2	-0.7
Water consumed over 24 hours	0.5	0.6	1.0	-0.0	-0.8	1.0
Indifference point 0 sec	0.7	1.1	2.0	-1.4	1.0	0.6
Indifference point AUC	2.2	2.6	4.3	-0.4	2.1	-1.8
Indifference point function ln k	1.1	1.6	1.9	1.0	-1.4	1.3
Indifference point function log k	1.1	1.6	1.9	1.0	-1.4	1.3
Delay discounting total patch changes 0 sec	0.7	1.1	2.3	-1.5	0.5	0.9
Delay discounting total patch changes 12 sec	0.6	0.8	1.4	-1.2	1.0	-0.2
Delay discounting total patch changes 18 sec	1.4	1.9	2.9	-1.7	1.5	-0.7
Delay discounting total patch changes 24 sec	1.1	1.3	3.0	-1.7	0.8	0.7
Delay discounting total patch changes 6 sec	1.3	2.0	3.6	-0.6	1.9	-1.4
Delay discounting time to switch 0 sec	0.2	0.3	0.8	0.4	-0.9	0.2
Delay discounting water rate 0 sec	0.2	0.3	0.4	-0.5	-0.7	0.5
Delay discounting water rate 12 sec	0.7	1.0	2.1	-0.4	-0.9	1.4
Delay discounting water rate 18 sec	0.6	0.8	2.2	-0.1	0.1	1.5
Delay discounting water rate 24 sec	0.5	0.8	1.1	-1.0	-0.3	1.1
Delay discounting water rate 6 sec	0.1	0.1	0.3	-0.6	0.1	0.3
Locomotor activity	4.1	6.6	9.6	-3.1	0.9	3.1
Locomotor testing distance	3.6	6.0	8.4	-2.8	1.3	2.9
Locomotor testing rearing	0.1	0.1	0.2	-0.5	0.4	0.3
Light reinforcement 1	0.6	1.1	1.5	-1.1	1.2	0.6
Light reinforcement 2	1.0	1.3	2.6	0.4	1.6	-1.0
Reaction time number correct	1.0	1.5	2.2	1.1	1.1	-1.5
Reaction time mean minus median	0.2	0.2	0.4	-0.5	0.7	0.1
Reaction time mean minus median AUC	0.4	0.5	0.8	-0.9	0.9	-0.2
Reaction time num false alarms	0.3	0.4	0.5	0.7	-0.5	-0.6
Reaction time num false alarms AUC	0.1	0.2	0.3	0.4	-0.3	-0.6
Reaction time trials correct on left	1.0	1.5	2.2	1.1	1.1	-1.5
Reaction time trials on left	1.1	1.5	2.2	1.1	1.0	-1.5
Reaction time mean	0.2	0.2	0.4	0.2	-0.7	-0.4
Reaction time mean AUC	0.3	0.3	0.7	0.2	-0.5	-0.8
Median of all reaction times	0.3	0.4	0.6	0.5	-0.7	-0.8
Reaction time omissions	0.6	0.8	1.3	0.6	-0.8	-1.2
Reaction time false alarm rate	0.3	0.4	1.2	-0.0	-1.1	0.3
Reaction time premature initiation rate	0.7	0.9	1.7	-1.3	0.6	0.7
Reaction time premature initiations	0.3	0.4	0.9	-0.6	0.9	0.1
Std. dev. reaction times	0.1	0.2	0.4	-0.3	0.3	-0.7
Reaction time trials completed	1.1	1.5	2.2	1.1	1.0	-1.5
Reaction time trials AUC	1.3	1.9	2.8	1.3	1.1	-1.7
Social response proportion	0.1	0.1	0.2	-0.4	-0.2	-0.3
Social responses	0.5	0.6	1.1	-0.8	1.0	0.0
Social time	0.4	0.6	0.7	0.8	-0.7	0.7
Conditioned locomotion	2.0	2.4	4.5	1.6	0.4	-2.1
Cocaine response after cond. corrected	0.5	0.5	1.0	-0.7	-0.2	1.0
Cocaine response after cond. not corrected	1.4	1.5	2.2	-1.5	0.6	1.4
Cocaine response before conditioning	0.7	0.8	1.5	-0.9	1.2	0.5
Saline control response	1.1	1.5	2.4	-1.5	1.5	0.0
Condit. Reinf. active minus inactive responses	1.1	1.4	2.6	-1.2	0.2	1.6
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.6	-1.0	0.5	1.3
Condit. Reinf. active responses	1.2	1.6	3.2	-1.3	-0.1	1.8
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.1	-0.6	0.4
Condit. Reinf. lever presses	1.4	1.9	3.8	-1.3	0.1	2.0
Condit. Reinf. lever reinforcers received	1.3	1.8	3.5	-1.4	-0.2	1.9
Pavlov. Cond. lever latency	0.3	0.3	0.9	0.4	-0.1	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.5	-0.4	0.3
Pavlov. Cond. change in total contacts	1.7	2.3	4.8	-1.5	-0.0	2.2
Pavlov. Cond. index score	0.4	0.5	1.4	-0.0	-0.2	1.2
Pavlov. Cond. latency score	0.4	0.5	1.3	0.0	-0.3	1.1
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.8	0.7	1.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	-0.8	0.5	0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.2	0.7	-1.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	0.0	-0.2	1.2
Pavlov. Cond. response bias	0.1	0.2	0.5	0.1	0.2	0.7
Conditioned reinforcement - actives	0.2	0.2	0.4	0.3	-0.4	-0.6
Conditioned reinforcement - inactives	1.4	1.6	3.4	1.0	-1.9	-0.4
Conditioned locomotion	1.0	1.1	1.7	0.3	1.3	-1.3
Intermittent access intake day 1-15 change	2.6	2.5	5.9	1.3	-2.4	0.3
Intermittent access intake escalation	2.0	1.9	4.1	1.3	-2.0	-0.0
Intermittent access intake escalation 2	2.0	2.0	4.4	0.9	-2.1	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.1	-0.4	-0.3
Intermitt. access day 15 inactive lever presses	1.8	2.0	4.7	1.0	-2.2	0.4
Intermitt. access escalation Index	0.5	0.5	1.2	-0.1	1.1	-0.4
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	0.4	-0.1
Intermittent access day 15 total infusions	0.5	0.5	0.9	0.9	-0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	0.7	-0.3	-0.5
Intermittent access total infusions	0.3	0.3	0.6	0.8	-0.3	-0.6
Intermittent access day 1 locomotion	0.4	0.5	1.0	0.1	1.0	-0.6
Intermittent access day 15 total locomotion	2.1	2.3	4.1	1.2	1.1	-2.0
Intermittent access total locomotion	2.1	2.4	3.9	1.3	1.3	-2.0
Intermittent access standard deviation	1.3	1.4	3.2	0.6	-1.8	0.8
Cocaine induced anxiety	0.4	0.4	0.8	-0.1	-0.7	0.9
Post-drug Anxiety	0.2	0.2	0.4	-0.3	-0.6	0.4
Baseline Anxiety	0.5	0.6	1.1	1.0	-0.6	-0.6
Lifetime Intake	0.4	0.5	0.8	0.8	0.1	-0.9
Incentive Sensitization - Responses	0.9	0.9	1.3	1.2	-1.1	-0.3
Incentive Sensitization - Breakpoint	0.9	0.9	1.4	1.2	-1.2	-0.2
Progressive ratio test 1 active lever presses	0.7	0.8	1.1	0.1	1.1	-1.1
Progressive ratio test 1 breakpoint	0.8	0.8	1.2	0.1	1.1	-1.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	1.0	0.5	-1.0	-0.1
Progressive ratio test 2 active lever presses	0.6	0.6	1.0	1.0	-0.2	-0.9
Progressive ratio test 2 breakpoint	0.4	0.4	0.7	0.8	-0.4	-0.6
Progressive ratio test 2 inactive lever presses	3.1	3.6	8.1	1.4	-2.8	0.9
Total sessions with >9 infusions	0.2	0.2	0.6	0.2	-0.8	0.0
Short access day 1 total inactive lever presses	2.4	2.7	4.5	2.1	-0.9	-1.7
Short access day 10 total inactive lever presses	0.9	1.0	2.7	-0.2	-1.6	0.4
Short access day 1 total infusions	0.4	0.4	0.9	0.6	-0.2	-0.9
Short access day 10 total infusions	0.5	0.5	1.1	0.6	0.5	-1.0
Short access total infusions	1.3	1.4	2.8	1.0	0.7	-1.7
Short access day 1 locomotion	0.6	0.6	1.4	0.1	0.6	-1.2
Short access day 10 total locomotion	1.4	1.6	2.8	0.1	1.7	-1.4
Short access total locomotion	2.0	2.1	3.4	-0.2	1.8	-1.7
Compulsive drug intake	1.2	1.2	2.2	0.1	1.5	-1.2
One hour access (0.3 mA shock)	1.0	1.2	2.3	0.7	0.8	-1.5
One hour access (shock baseline)	0.1	0.2	0.3	0.4	-0.6	-0.1
Number of responses in last shaping day	0.6	0.6	1.5	0.6	-1.2	0.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.1	0.2	0.5
Locomotion velocity, session 1	1.3	1.4	3.3	0.3	1.8	-0.8
Locomotion distance, session 1	1.5	1.9	4.8	-0.8	2.2	0.6
Locomotion velocity, session 2	0.2	0.3	0.5	0.7	0.0	0.5
Locomotion distance, session 2	0.3	0.5	1.3	0.4	1.2	0.1
Locomotion velocity, session 3	0.6	0.7	2.1	0.0	1.4	-0.0
Locomotion distance, session 3	0.7	0.7	1.9	1.4	0.2	-0.6
Stereotopy head waving bouts, day 3	1.2	1.4	2.6	-0.3	-1.6	1.3
Stereotopy head waving duration, day 3	0.3	0.4	0.5	-0.7	-0.7	0.5
Locomotion velocity, session 7	0.2	0.2	0.4	-0.1	0.4	-0.6
Locomotion distance, session 7	0.8	1.0	1.6	1.3	-0.3	-1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.0	0.3	-0.3
Stereotopy head waving duration, day 7	0.3	0.4	0.6	-0.7	0.8	0.2
Locomotion velocity, session 8	0.6	0.7	1.9	-0.2	1.4	0.3
Locomotion distance, session 8	1.4	2.1	6.0	-0.3	2.4	0.3
Degree of sensitization distance	0.5	0.5	1.5	-1.2	-0.1	0.1
Degree of sensitization stereotypy	0.6	0.6	1.3	-0.3	1.2	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.0	-0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.3	-0.0
Condit. Reinf. active responses	0.1	0.1	0.4	0.1	-0.7	0.1
Condit. Reinf. inactive responses	0.2	0.3	0.4	0.5	-0.6	0.3
Incentive salience index mean	0.1	0.1	0.2	0.3	-0.5	-0.3
Condit. Reinf. lever presses	0.7	0.9	1.6	1.3	-0.8	-0.7
Time in familiar zone, hab. session 1	1.7	1.6	3.3	0.9	-1.8	-0.9
Time in novel zone, hab. session 1	0.6	0.5	0.8	-0.6	0.9	0.7
Total zone transitions, hab. session 1	0.6	0.9	2.1	-0.5	1.4	0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.3	-0.6	0.5	0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.6	0.8	0.3
Time in familiar zone, hab. session 2	0.7	0.7	1.6	0.7	-1.3	-0.2
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.0	1.1	-0.4
Total zone transitions, hab. session 2	0.4	0.5	0.9	0.1	0.9	0.8
Total locomotion distance, hab. session 2	0.3	0.4	0.5	-0.7	0.5	0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.4	-0.6	0.7	0.6
Novel to familiar place preference ratio	2.3	2.4	6.0	-0.8	2.4	-0.8
Novelty place preference	2.7	2.8	6.7	-0.8	2.6	-1.0
Time in novel zone, NPP test	2.2	2.3	5.3	-0.9	2.3	-0.8
Total zone transitions, NPP test	2.3	3.2	5.3	-1.4	2.3	1.5
Total locomotion distance, NPP test	1.0	1.4	2.2	-1.2	0.7	1.5
Locomotion velocity, NPP test	1.0	1.5	1.8	-1.2	1.1	1.3
Pavlov. Cond. lever latency	2.4	3.1	6.3	-2.5	1.5	0.9
Pavlov. Cond. magazine entry latency	3.5	4.6	8.1	2.8	-2.1	-1.1
Pavlov. Cond. change in total contacts	1.7	1.8	2.7	1.3	-1.6	-1.0
Pavlov. Cond. index score	4.0	5.1	7.6	2.8	-2.6	-0.9
Pavlov. Cond. latency score	3.5	4.4	7.8	2.8	-2.1	-1.1
Pavlov. Cond. lever contacts	1.6	1.9	3.1	1.8	-1.5	-0.5
Pavlov. Cond. magazine entry number	4.3	5.4	8.4	-2.9	2.5	1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	4.0	5.0	8.1	2.6	-2.9	-0.6
Pavlov. Cond. response bias	4.2	5.2	7.8	2.8	-2.6	-0.9
Bone: apparent density	0.5	0.9	2.3	-0.0	1.5	-0.6
Bone surface	0.1	0.2	0.2	0.5	0.4	-0.1
Bone volume	0.4	0.6	1.7	0.3	1.3	-0.3
Bone: connectivity density	0.8	1.3	2.2	0.5	1.2	-1.5
Bone: cortical apparent density	0.4	0.5	1.1	0.4	0.4	-1.1
Bone: cortical area	0.6	0.9	1.7	0.6	-1.3	0.8
Bone: cortical porosity	1.6	1.8	3.2	0.1	1.5	-1.8
Bone: cortical porosity	1.9	2.0	3.9	0.3	1.4	-2.0
Bone: cortical thickness	1.2	2.0	3.2	-0.2	-1.8	1.7
Bone: cortical thickness	0.0	0.0	0.1	-0.0	-0.4	-0.1
Bone: cortical tissue density	0.4	0.6	1.3	0.4	0.5	-1.1
Bone: elastic displacement	0.5	0.6	0.9	-0.1	-0.9	0.9
Bone: elastic work	0.6	0.7	1.8	-0.5	-0.4	1.4
Bone: endosteal estimation	0.2	0.5	0.7	-0.2	0.9	-0.8
Bone: endosteal perimeter	0.7	1.5	2.6	1.6	0.4	-1.3
Bone: final force	0.9	1.6	3.5	-1.0	-0.5	1.9
Bone: final moment	1.2	2.0	4.5	-1.1	-0.6	2.1
Bone: marrow area	0.2	0.5	0.7	-0.3	0.9	-0.7
Bone: maximum diameter	0.3	0.6	0.9	0.8	-1.0	0.2
Bone: maximum force	0.4	0.7	1.3	-0.9	-0.2	1.1
Bone: maximum moment	0.5	0.9	1.7	-1.0	-0.3	1.3
Bone: minimum diameter	0.2	0.4	1.1	1.1	-0.0	-0.2
Bone: periosteal estimation	0.0	0.0	0.0	0.1	-0.1	0.1
Bone: periosteal perimeter	0.6	0.9	2.3	1.5	-0.2	-0.7
Bone: post-yield work	0.1	0.1	0.3	-0.1	-0.5	0.3
Bone: stiffness	0.0	0.0	0.1	-0.3	0.1	0.1
Bone: tissue strength	2.2	2.1	3.2	-1.5	-1.0	1.8
Bone: trabecular number	1.3	2.1	2.6	1.1	1.5	-1.6
Bone: trabecular spacing	2.5	3.2	5.1	-1.4	-1.6	2.3
Bone: trabecular thickness	1.1	1.4	3.6	-0.1	1.9	-0.7
Bone: trabecular tissue density	0.1	0.2	0.5	-0.7	0.1	0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.6	0.1	-0.1
Distance traveled before self-admin	0.4	0.5	0.9	0.9	0.6	0.4
Distance traveled after self-admin	1.0	1.1	1.9	1.4	1.0	-0.7
Delta time in closed arm before/after self-admin	0.8	0.7	1.3	0.0	1.0	-1.1
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.5	-0.1
Diff in mean of infusions in LGA sessions	4.0	4.5	9.0	-0.6	-3.0	2.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	-0.1	-0.0
Active lever presses in extinction session 6	2.3	2.2	5.0	-0.1	2.2	-1.3
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.3	0.1	-0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	-0.6	0.7	-0.2
Time in closed arm before self-admin	1.0	1.1	1.8	-0.7	-1.3	1.1
Time in closed arm after self-admin	0.0	0.0	0.1	-0.2	0.1	-0.2
Time in open arm before self-admin	0.3	0.3	0.6	0.8	0.0	-0.5
Time in open arm after self-admin	2.0	2.2	3.2	0.7	1.8	-1.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.4	0.2	0.5
Time to tail flick, vehicle, before self-admin	1.7	1.7	2.4	-1.6	-0.9	1.3
Time to tail flick, vehicle, after self-admin	3.2	3.5	6.1	-0.8	-1.9	2.5
Time to tail flick, test, before self-admin	0.7	0.7	1.1	-0.4	1.1	-0.9
Time to tail flick, test, after self-admin	1.6	1.6	3.9	0.2	-2.0	0.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.9	0.8	-1.4	1.0
Delta time to tail flick, test, before/after SA	1.4	1.3	3.2	0.6	-1.8	0.5
Ambulatory time before self-admin	0.9	0.9	1.4	1.2	-1.1	0.3
Ambulatory time after self-admin	2.2	2.4	4.3	1.2	2.1	-1.2
Total heroin consumption	2.0	2.4	4.3	-1.0	-1.4	2.1
Area under the delay curve	1.7	1.9	3.4	1.2	0.8	-1.9
Delay disc. indifference point, 0s delay	0.6	0.6	1.0	-0.2	0.9	-1.0
Delay disc. indifference point, 16s delay	1.1	1.1	2.0	0.8	0.7	-1.4
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	0.5	0.8	-0.9
Delay disc. indifference point, 24s delay	1.0	1.0	1.7	1.0	0.6	-1.3
Delay disc. indifference point, 4s delay	1.3	1.3	2.8	1.1	0.3	-1.7
Delay disc. indifference point, 8s delay	1.4	1.5	2.1	1.4	0.7	-1.4
Delay discount exponential model param	1.6	1.7	3.0	-1.3	-0.5	1.7
Delay discount hyperbolic model param	1.7	1.8	3.3	-1.3	-0.6	1.8
Fecal boli incidents, locomotor time 1	1.1	1.2	2.4	-1.0	-0.5	1.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.0	0.6	-0.7
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.9	0.2	-0.7
Bouts of movement, locomotor time 1	0.4	0.4	0.7	-0.5	-0.8	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	-0.6	0.5
Rest time, locomotor task time 1	0.4	0.4	1.0	0.5	0.4	-1.0
Distance moved, locomotor task time 1	1.2	1.3	2.8	-1.0	-0.4	1.7
Vertical activity count, locomotor time 1	1.1	1.1	2.5	-0.9	-0.2	1.6
Time >=10cm from walls, locomotor time 2	0.8	0.9	1.1	-1.0	0.9	0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.3	-0.1	-0.3
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.5	-0.0	-0.6
Rest time, locomotor task time 2	0.6	0.7	1.3	-0.4	1.1	-0.8
Distance moved, locomotor task time 2	0.7	0.8	2.2	-0.4	-0.2	1.5
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.2	0.2	0.8
Weight adjusted by age	1.1	1.2	3.2	-0.4	-0.6	1.8
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	2.2	1.5	0.9	-1.5
Locomotion in novel chamber	0.2	0.3	0.4	0.5	0.6	-0.3
Locomotion in novel chamber post-restriction	0.7	0.8	2.1	-0.6	1.4	-0.1
Progressive ratio	4.2	4.9	10.8	-1.8	3.3	0.7
Food seeking constrained by brief footshock	1.2	1.4	2.2	1.5	0.7	-1.2
Seeking ratio, punishment vs. effort	5.3	6.5	12.2	2.6	-3.5	-0.8
Run reversals in cocaine runway, females	2.5	2.5	5.0	1.6	-2.2	-0.1
Run reversals in cocaine runway, males	1.6	1.6	3.1	-0.7	-1.1	1.8
Latency to leave start box in cocaine runway	0.7	0.8	1.3	-1.1	0.8	0.6
Latency to leave start box in cocaine runway, F	2.1	2.3	3.7	-1.4	-1.0	1.9
Latency to leave start box in cocaine runway, M	3.8	3.6	9.0	0.1	3.0	-1.4
Cd content in liver	1.3	1.4	3.2	-1.8	-0.5	0.9
Co content in liver	0.6	0.6	1.5	0.3	-1.2	0.6
Cu content in liver	2.2	2.6	6.2	-2.5	0.5	1.1
Fe content in liver	1.2	1.4	3.0	-1.7	-0.9	0.6
K content in liver	1.2	1.2	2.1	-1.1	0.6	1.5
Mg content in liver	0.3	0.3	1.0	-0.1	0.1	1.0
Mn content in liver	1.0	1.2	3.2	-0.5	1.8	-0.2
Na content in liver	0.3	0.3	0.7	-0.8	0.2	-0.5
Rb content in liver	0.9	1.1	1.7	-1.3	-1.3	0.3
Se content in liver	0.2	0.3	0.6	-0.4	0.3	0.7
Sr content in liver	0.2	0.2	0.4	0.1	0.4	0.6
Zn content in liver	2.8	3.0	5.6	-2.4	1.0	1.6