Hub : Genes

Sars2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000019962 0.13 0.09 6.4e-11 0.07 0.07 0.07 0.07 3.0e-08 6.9e-08 5.6e-08 4.6e-08
2 Adipose mRNA stability ENSRNOG00000019962 0.17 0.11 1.3e-12 0.08 0.07 0.08 0.08 7.4e-09 2.4e-08 5.4e-09 2.5e-09
3 BLA gene expression ENSRNOG00000019962 0.58 0.18 0.0e+00 0.47 0.46 0.47 0.2 5.8e-28 4.0e-27 4.0e-28 5.5e-11
4 Brain gene expression ENSRNOG00000019962 0.48 0.16 0.0e+00 0.39 0.39 0.41 0.41 1.5e-38 3.4e-38 2.5e-40 3.3e-40
5 Brain mRNA stability ENSRNOG00000019962 0.18 0.13 5.0e-12 0.14 0.12 0.13 0.14 9.5e-13 2.9e-11 6.8e-12 1.1e-12
6 IL gene expression ENSRNOG00000019962 0.42 0.18 2.0e-08 0.3 0.31 0.27 0.33 6.6e-08 4.3e-08 2.7e-07 1.1e-08
7 LHb gene expression ENSRNOG00000019962 0.47 0.2 3.3e-07 0.24 0.17 0.22 0.21 2.0e-06 6.1e-05 4.6e-06 9.3e-06
8 Liver gene expression ENSRNOG00000019962 0.38 0.18 0.0e+00 0.21 0.21 0.21 0.21 2.3e-23 1.8e-22 4.3e-23 3.1e-23
9 Liver intron excision ratio chr1:84033368:84034103 0.02 0.02 8.0e-03 0 0 0 0 2.6e-01 1.4e-01 9.1e-02 2.5e-01
10 Liver mRNA stability ENSRNOG00000019962 0.18 0.11 1.9e-14 0.09 0.08 0.08 0.09 5.1e-10 1.9e-09 1.5e-09 9.2e-10
11 NAcc gene expression ENSRNOG00000019962 0.5 0.17 0.0e+00 0.44 0.47 0.46 0.45 4.9e-36 1.2e-38 1.6e-37 9.3e-37
12 NAcc mRNA stability ENSRNOG00000019962 0.06 0.05 4.4e-04 0.05 0.03 0.02 0.04 1.9e-04 2.8e-03 6.0e-03 3.1e-04
13 OFC gene expression ENSRNOG00000019962 0.57 0.2 8.5e-11 0.4 0.39 0.39 0.39 1.4e-10 2.6e-10 2.4e-10 2.1e-10
14 OFC mRNA stability ENSRNOG00000019962 0.2 0.13 1.3e-03 0.11 0.1 0.08 0.1 1.7e-03 2.2e-03 5.0e-03 2.1e-03
15 PL gene expression ENSRNOG00000019962 0.48 0.16 0.0e+00 0.46 0.45 0.45 0.46 1.2e-38 4.6e-37 5.6e-38 2.5e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
BMI with tail0.10.30.9-0.6-0.6-0.7-0.5-0.5-0.6-0.7-0.4-0.9-0.5-0.5-0.5-0.5-0.5-0.5
BMI without tail0.20.30.70.40.40.30.60.60.50.30.6-0.20.60.60.60.80.80.6
Body weight2.510.413.33.43.43.43.02.93.33.42.92.92.93.22.93.63.73.4
Epididymis fat weight0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.2-0.3-0.1-0.1-0.2-0.10.0-0.2
Glucose0.40.71.7-0.8-0.8-0.7-0.8-0.8-0.8-0.8-0.81.3-0.8-0.9-0.8-0.5-0.5-0.8
Heart weight0.81.21.71.11.11.21.11.11.11.11.31.01.21.01.11.00.91.1
Left kidney weight2.98.39.33.02.93.12.72.83.03.02.82.62.82.82.83.03.13.0
Right kidney weight4.011.412.83.53.43.63.33.33.53.43.42.43.43.43.33.53.63.6
Tail length4.513.717.33.83.83.93.63.53.83.83.52.83.53.83.54.24.13.9
Length with tail6.925.129.65.35.25.44.84.65.25.34.64.54.65.04.65.35.45.2
Length without tail3.47.38.93.02.93.02.52.42.83.02.42.92.52.62.42.72.72.8
Liver weight, left0.00.10.1-0.2-0.3-0.2-0.3-0.2-0.2-0.3-0.2-0.3-0.2-0.2-0.2-0.1-0.1-0.3
Liver weight, right0.00.00.30.20.20.20.10.10.10.20.10.60.10.10.10.10.10.2
Parametrial fat weight0.40.91.2-0.9-1.0-0.9-1.0-1.0-1.0-1.0-0.90.3-0.9-1.1-1.0-1.0-0.9-1.0
Retroperitoneal fat weight1.03.24.0-1.8-1.9-1.7-2.0-2.0-1.8-1.8-2.0-0.6-1.9-1.8-2.0-1.6-1.6-1.7
Intraocular pressure0.10.20.3-0.5-0.5-0.4-0.4-0.3-0.4-0.5-0.50.6-0.3-0.4-0.3-0.2-0.2-0.3
Extensor digitorum longus weight0.20.81.1-0.9-0.9-0.9-0.9-0.8-0.9-0.9-0.8-0.4-0.8-0.9-0.8-1.0-0.9-0.9
Soleus weight1.03.06.2-1.7-1.6-1.7-1.6-1.7-1.7-1.7-1.7-2.5-1.7-1.4-1.7-1.7-1.6-1.7
Tibialis anterior weight0.00.11.8-0.0-0.0-0.10.10.20.00.00.1-1.40.20.20.2-0.00.00.0
Tibia length2.15.86.32.42.42.52.42.42.42.42.42.42.42.32.42.52.42.5
Number of licking bursts1.82.13.2-1.5-1.4-1.4-1.4-1.4-1.5-1.5-1.40.5-1.4-1.7-1.4-1.8-1.7-1.5
Food consumed during 24 hour testing period0.40.52.50.60.60.70.70.70.60.60.71.60.70.50.70.60.40.6
Times rat made contact with spout0.40.41.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-1.3-0.6-0.5-0.6-0.5-0.5-0.6
Mean time between licks in bursts0.20.20.30.60.60.60.50.40.50.60.40.60.40.40.40.30.40.5
Mean num. licks in bursts0.80.91.60.90.90.80.80.80.90.90.8-1.30.81.20.81.31.10.9
Std. dev. time between licks in bursts0.50.61.00.80.80.80.70.70.80.80.7-0.20.70.90.70.81.00.7
Water consumed over 24 hours0.91.11.61.01.01.11.11.01.11.01.01.31.01.01.01.11.11.0
Indifference point 0 sec0.30.50.80.70.70.70.80.90.70.70.80.70.90.60.90.60.50.7
Indifference point AUC0.60.72.7-0.5-0.6-0.7-1.0-1.0-0.7-0.6-1.1-1.6-1.0-0.5-1.0-0.6-0.5-0.5
Indifference point function ln k0.60.93.80.70.70.90.91.00.80.71.12.01.10.51.00.70.60.7
Indifference point function log k0.60.93.80.70.70.90.91.00.80.71.12.01.10.51.00.70.60.7
Delay discounting total patch changes 0 sec0.40.71.00.80.80.80.91.00.80.80.90.90.90.71.00.70.50.8
Delay discounting total patch changes 12 sec0.20.30.50.70.70.60.50.50.60.70.4-0.20.40.70.50.60.50.7
Delay discounting total patch changes 18 sec0.40.54.4-0.2-0.3-0.4-0.6-0.6-0.3-0.3-0.8-2.1-0.8-0.1-0.6-0.3-0.3-0.2
Delay discounting total patch changes 24 sec0.50.60.90.90.80.90.60.70.80.80.50.20.50.80.70.80.80.9
Delay discounting total patch changes 6 sec0.10.10.40.30.30.30.20.30.30.30.2-0.60.20.40.30.40.30.4
Delay discounting time to switch 0 sec1.42.13.0-1.4-1.4-1.5-1.5-1.6-1.4-1.4-1.7-1.2-1.7-1.3-1.6-1.3-1.4-1.4
Delay discounting water rate 0 sec0.40.61.6-0.8-0.8-0.7-0.7-0.6-0.8-0.8-0.51.2-0.5-0.9-0.6-0.7-0.7-0.7
Delay discounting water rate 12 sec0.91.44.61.11.11.21.11.01.11.01.12.11.01.01.01.11.01.2
Delay discounting water rate 18 sec0.60.81.3-1.0-0.9-0.8-0.8-0.8-0.9-0.9-0.61.0-0.6-1.1-0.8-1.0-1.0-1.0
Delay discounting water rate 24 sec0.60.82.70.70.70.80.90.90.70.71.01.61.00.60.90.60.60.8
Delay discounting water rate 6 sec0.20.33.40.20.20.40.30.40.30.20.41.80.30.10.40.30.10.3
Locomotor activity0.50.81.8-0.8-0.8-0.9-1.0-1.0-0.8-0.8-1.1-1.4-1.1-0.7-1.0-0.5-0.6-0.8
Locomotor testing distance0.91.52.0-1.2-1.2-1.2-1.3-1.2-1.2-1.2-1.2-1.4-1.2-1.1-1.2-1.1-1.2-1.1
Locomotor testing rearing1.62.510.5-1.4-1.4-1.5-1.5-1.4-1.4-1.4-1.4-3.2-1.4-1.1-1.4-1.2-1.4-1.2
Light reinforcement 10.20.40.8-0.6-0.6-0.6-0.8-0.8-0.6-0.6-0.9-0.4-0.8-0.5-0.8-0.5-0.5-0.5
Light reinforcement 26.78.910.5-3.2-3.1-3.1-3.0-3.0-3.1-3.2-2.9-0.5-3.0-3.2-3.0-3.0-3.1-3.2
Reaction time number correct0.10.10.30.20.30.30.40.40.30.30.50.30.50.30.40.30.30.4
Reaction time mean minus median0.30.40.80.60.60.60.60.60.60.60.60.90.70.50.60.40.50.6
Reaction time mean minus median AUC0.50.72.20.90.80.80.70.70.70.80.81.50.90.50.70.50.60.7
Reaction time num false alarms0.71.01.4-1.1-1.1-1.2-1.0-0.9-1.1-1.1-0.8-0.7-0.9-1.1-0.9-1.1-0.9-1.2
Reaction time num false alarms AUC1.01.41.9-1.3-1.3-1.4-1.2-1.1-1.3-1.3-1.0-0.8-1.0-1.3-1.1-1.3-1.2-1.4
Reaction time trials correct on left0.10.10.30.20.30.30.40.40.30.30.50.30.50.30.40.30.30.4
Reaction time trials on left0.10.10.30.20.20.30.40.40.30.20.50.30.50.30.40.30.20.3
Reaction time mean0.10.10.6-0.2-0.2-0.2-0.1-0.1-0.2-0.2-0.10.8-0.0-0.4-0.1-0.3-0.3-0.3
Reaction time mean AUC0.20.21.3-0.4-0.4-0.4-0.2-0.2-0.4-0.4-0.21.1-0.1-0.6-0.2-0.5-0.5-0.5
Median of all reaction times0.20.20.4-0.6-0.5-0.5-0.3-0.3-0.5-0.5-0.30.6-0.3-0.6-0.3-0.5-0.5-0.6
Reaction time omissions0.10.10.2-0.4-0.4-0.4-0.2-0.1-0.4-0.4-0.1-0.1-0.1-0.4-0.1-0.4-0.5-0.4
Reaction time false alarm rate1.11.62.1-1.3-1.3-1.4-1.3-1.2-1.3-1.3-1.2-0.6-1.2-1.3-1.2-1.3-1.2-1.5
Reaction time premature initiation rate0.00.00.10.10.1-0.0-0.1-0.1-0.00.1-0.1-0.3-0.10.0-0.1-0.00.1-0.0
Reaction time premature initiations0.00.00.10.20.20.20.10.00.10.20.1-0.10.20.20.00.10.10.2
Std. dev. reaction times0.20.31.40.50.50.50.50.50.40.50.51.20.60.30.50.20.30.4
Reaction time trials completed0.10.10.30.20.20.30.40.40.30.20.50.30.50.30.40.30.20.3
Reaction time trials AUC0.00.10.20.10.20.20.30.30.20.10.40.20.40.20.30.20.10.3
Social response proportion5.25.77.12.32.42.42.62.62.42.22.61.52.72.32.62.32.12.3
Social responses0.10.20.90.10.10.30.40.40.30.10.41.00.50.20.40.40.30.3
Social time0.30.40.60.50.50.60.60.70.70.50.6-0.40.70.70.70.70.80.7
Conditioned locomotion0.70.83.10.80.80.90.80.90.80.80.91.80.90.60.90.70.70.9
Cocaine response after cond. corrected0.50.61.40.70.70.70.80.80.70.70.81.20.80.60.80.80.80.6
Cocaine response after cond. not corrected0.91.01.80.90.91.01.01.01.00.91.01.31.00.81.01.01.00.9
Cocaine response before conditioning1.72.12.41.51.51.61.51.51.51.51.50.51.51.51.51.31.41.5
Saline control response0.50.71.20.70.70.60.80.90.80.70.9-1.10.90.90.90.80.80.7
Condit. Reinf. active minus inactive responses4.55.66.42.42.42.42.52.52.42.42.51.02.52.42.52.32.22.4
Condit. Reinf. active-inactive response ratio3.33.54.11.91.91.82.02.01.91.92.0-0.02.02.02.01.71.72.0
Condit. Reinf. active responses4.96.87.72.72.72.72.82.82.72.72.81.32.82.72.82.62.52.7
Condit. Reinf. inactive responses1.21.51.71.31.31.31.21.21.31.31.20.61.21.31.21.31.21.3
Condit. Reinf. lever presses6.69.19.83.03.13.13.13.13.03.03.12.43.12.93.12.92.83.1
Condit. Reinf. lever reinforcers received6.08.49.42.92.93.03.03.12.92.93.11.93.12.93.12.82.73.0
Pavlov. Cond. lever latency2.94.04.4-2.0-2.0-2.1-2.0-2.1-2.0-2.0-2.1-1.6-2.1-2.0-2.1-2.1-1.9-2.1
Pavlov. Cond. magazine entry latency1.82.05.81.31.31.41.31.41.31.31.42.41.41.11.41.31.31.3
Pavlov. Cond. change in total contacts5.78.08.72.92.92.92.92.92.92.92.91.72.92.92.92.82.72.9
Pavlov. Cond. index score2.63.44.11.81.81.91.81.91.81.81.92.01.91.71.91.81.71.8
Pavlov. Cond. latency score2.53.14.51.71.71.81.81.81.81.71.82.11.81.61.81.81.71.7
Pavlov. Cond. lever contacts2.83.84.22.02.02.02.02.02.02.02.01.52.01.92.02.01.92.0
Pavlov. Cond. magazine entry number0.91.23.3-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.8-1.0-0.9-1.0-1.0-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.70.81.1-0.9-0.9-0.9-0.9-1.0-1.0-0.9-1.00.2-1.0-1.0-1.0-1.0-1.1-0.9
Pavlov. Cond. lever-magazine prob. diff.3.03.94.51.91.92.02.02.02.01.92.02.12.01.82.02.01.91.9
Pavlov. Cond. response bias3.24.44.82.12.12.22.22.22.12.12.21.82.22.02.22.12.02.1
Conditioned reinforcement - actives0.60.61.60.50.50.60.81.00.60.51.01.30.90.41.00.50.70.5
Conditioned reinforcement - inactives2.22.43.81.61.61.61.51.51.61.61.42.01.41.41.51.51.71.6
Conditioned locomotion0.80.91.4-1.2-1.1-1.1-0.8-0.7-1.1-1.2-0.50.3-0.8-1.2-0.7-1.2-1.0-1.2
Intermittent access intake day 1-15 change0.90.91.81.01.01.00.90.81.01.00.70.10.81.10.81.21.31.0
Intermittent access intake escalation0.80.71.40.80.80.80.80.90.90.80.70.20.80.90.91.11.20.8
Intermittent access intake escalation 22.92.93.81.71.71.71.71.71.81.71.5-0.61.61.91.71.91.91.7
Intermitt. access day 1 inactive lever presses0.40.54.40.40.40.50.40.40.40.40.52.10.30.20.40.60.60.4
Intermitt. access day 15 inactive lever presses0.40.44.70.30.30.40.20.30.30.30.32.20.20.10.30.40.30.3
Intermitt. access escalation Index0.30.20.60.40.40.30.60.60.40.40.8-0.30.80.40.60.20.20.4
Intermittent access day 1 total infusions0.40.43.30.10.20.20.60.70.10.10.91.80.7-0.10.7-0.1-0.00.1
Intermittent access day 15 total infusions1.21.42.21.01.11.11.31.31.11.01.31.51.30.91.31.01.11.0
Intermittent access terminal intake (last 3 days)1.82.02.41.31.41.41.51.61.41.31.51.31.51.31.61.31.41.3
Intermittent access total infusions1.01.13.20.80.90.91.21.30.90.81.31.81.20.71.30.80.80.8
Intermittent access day 1 locomotion0.50.53.20.00.10.10.60.90.20.01.21.80.8-0.10.9-0.10.00.0
Intermittent access day 15 total locomotion0.10.11.0-0.2-0.2-0.10.10.2-0.1-0.20.41.00.1-0.30.2-0.1-0.0-0.2
Intermittent access total locomotion0.30.31.1-0.7-0.6-0.6-0.3-0.2-0.6-0.70.11.1-0.2-0.8-0.2-0.6-0.5-0.7
Intermittent access standard deviation4.14.45.72.22.22.12.12.02.22.21.80.22.02.42.02.42.42.2
Cocaine induced anxiety0.00.00.40.10.00.0-0.1-0.1-0.00.1-0.1-0.7-0.10.0-0.1-0.2-0.30.1
Post-drug Anxiety0.50.51.0-0.6-0.7-0.7-0.7-0.6-0.7-0.6-0.6-1.0-0.6-0.7-0.6-0.9-1.0-0.6
Baseline Anxiety0.00.00.1-0.3-0.3-0.3-0.10.1-0.3-0.30.10.20.1-0.30.1-0.2-0.2-0.3
Lifetime Intake0.40.42.10.30.30.30.70.80.40.30.81.50.80.20.80.20.30.3
Incentive Sensitization - Responses0.10.10.9-0.0-0.10.0-0.10.0-0.1-0.0-0.00.90.0-0.20.0-0.1-0.0-0.0
Incentive Sensitization - Breakpoint0.10.10.4-0.2-0.3-0.2-0.4-0.2-0.3-0.2-0.30.7-0.2-0.4-0.2-0.3-0.2-0.2
Progressive ratio test 1 active lever presses2.72.85.91.31.41.41.81.91.51.32.02.41.91.31.91.41.51.3
Progressive ratio test 1 breakpoint3.23.35.81.61.61.71.92.01.61.62.22.42.01.42.01.61.71.6
Progressive ratio test 1 inactive lever presses0.60.73.70.50.50.50.70.90.60.51.01.90.90.30.90.60.90.5
Progressive ratio test 2 active lever presses1.11.24.40.80.80.91.11.20.80.81.32.11.20.61.20.80.90.8
Progressive ratio test 2 breakpoint1.21.35.40.80.80.91.11.30.90.81.42.31.30.61.30.80.90.8
Progressive ratio test 2 inactive lever presses2.83.36.31.71.71.81.81.81.71.72.02.51.81.51.81.71.91.7
Total sessions with >9 infusions0.10.10.4-0.10.0-0.00.40.60.1-0.10.50.30.50.00.6-0.00.2-0.1
Short access day 1 total inactive lever presses0.50.51.90.60.60.70.60.80.60.60.71.40.70.50.80.50.60.7
Short access day 10 total inactive lever presses0.20.21.70.30.30.40.40.50.30.30.51.30.40.20.50.30.40.3
Short access day 1 total infusions0.60.71.30.70.70.70.80.90.70.71.01.21.00.60.90.70.80.7
Short access day 10 total infusions0.10.10.5-0.2-0.2-0.20.20.3-0.2-0.20.30.70.3-0.30.3-0.4-0.3-0.2
Short access total infusions0.10.10.8-0.3-0.2-0.10.10.3-0.2-0.30.40.90.3-0.30.3-0.3-0.2-0.3
Short access day 1 locomotion1.11.11.6-1.3-1.3-1.1-1.1-0.9-1.1-1.3-0.8-0.8-1.0-1.1-0.9-1.1-0.9-1.3
Short access day 10 total locomotion0.60.71.80.50.60.61.01.10.70.51.31.11.00.51.10.60.70.5
Short access total locomotion0.10.10.3-0.4-0.4-0.20.10.3-0.2-0.40.50.50.3-0.40.3-0.3-0.2-0.4
Compulsive drug intake0.30.30.70.50.50.40.50.50.50.50.5-0.80.60.70.50.60.50.5
One hour access (0.3 mA shock)1.51.82.91.11.21.21.51.71.31.11.61.21.61.11.71.11.11.1
One hour access (shock baseline)0.40.51.90.40.40.50.70.90.50.40.71.40.80.30.90.40.50.4
Number of responses in last shaping day2.52.53.51.61.61.71.51.51.61.61.51.21.51.61.51.71.91.6
Context. condit. distance diff. score0.10.10.1-0.2-0.2-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3
Locomotion velocity, session 12.62.83.4-1.6-1.6-1.7-1.6-1.6-1.6-1.6-1.6-1.7-1.6-1.6-1.6-1.8-1.8-1.7
Locomotion distance, session 10.81.01.11.01.01.01.01.01.01.01.00.71.01.01.01.01.01.0
Locomotion velocity, session 20.40.40.6-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.7-0.5-0.7-0.6-0.7-0.6-0.5-0.7
Locomotion distance, session 20.50.72.5-0.8-0.8-0.9-0.8-0.7-0.7-0.7-0.8-1.6-0.7-0.6-0.7-0.7-0.7-0.8
Locomotion velocity, session 30.30.33.2-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.31.8-0.3-0.6-0.3-0.4-0.5-0.3
Locomotion distance, session 36.26.87.22.62.62.62.62.62.62.62.62.42.62.52.62.72.72.6
Stereotopy head waving bouts, day 30.30.41.2-0.4-0.4-0.6-0.5-0.5-0.5-0.4-0.5-1.1-0.5-0.5-0.5-0.8-0.8-0.5
Stereotopy head waving duration, day 32.32.83.3-1.6-1.6-1.7-1.7-1.7-1.7-1.6-1.7-1.5-1.7-1.6-1.7-1.8-1.8-1.7
Locomotion velocity, session 70.10.11.1-0.1-0.1-0.0-0.1-0.2-0.10.0-0.21.0-0.2-0.1-0.20.20.1-0.1
Locomotion distance, session 70.10.11.20.30.30.30.20.20.30.40.21.10.20.20.20.40.30.3
Stereotopy head waving bouts, day 70.00.00.3-0.2-0.1-0.2-0.1-0.2-0.1-0.1-0.2-0.6-0.2-0.0-0.2-0.1-0.1-0.2
Stereotopy head waving duration, day 70.91.12.4-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.6-1.0-0.9-1.0-1.0-1.0-1.0
Locomotion velocity, session 82.83.44.0-1.8-1.8-1.9-1.9-2.0-1.9-1.7-2.0-0.6-1.9-1.9-2.0-2.0-2.0-1.9
Locomotion distance, session 80.40.62.3-0.6-0.6-0.8-0.6-0.7-0.6-0.6-0.7-1.5-0.7-0.5-0.7-0.7-0.8-0.7
Degree of sensitization distance3.63.74.1-1.9-1.9-1.9-2.0-2.0-2.0-1.8-2.0-1.1-2.0-1.9-2.0-2.0-2.0-1.9
Degree of sensitization stereotypy0.00.10.7-0.00.0-0.00.00.00.00.00.0-0.90.00.20.00.10.10.0
Condit. Reinf. active minus inactive responses0.20.20.5-0.5-0.4-0.4-0.4-0.4-0.5-0.5-0.40.2-0.4-0.5-0.4-0.7-0.7-0.5
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.3-0.3-0.3-0.4-0.4-0.3-0.4-0.2-0.4-0.4-0.4-0.6-0.6-0.4
Condit. Reinf. active responses0.91.21.3-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-0.1-1.1-1.1-1.1-1.1-1.1-1.1
Condit. Reinf. inactive responses0.70.81.0-0.9-1.0-1.0-1.0-0.9-0.9-1.0-0.9-0.4-0.9-0.9-0.9-0.7-0.7-0.9
Incentive salience index mean0.10.11.1-0.1-0.1-0.0-0.0-0.1-0.1-0.1-0.11.1-0.1-0.2-0.1-0.2-0.2-0.1
Condit. Reinf. lever presses0.10.21.10.40.40.40.40.30.40.40.31.10.30.30.30.50.40.3
Time in familiar zone, hab. session 10.20.20.30.40.40.40.40.40.40.40.4-0.20.40.50.40.60.50.4
Time in novel zone, hab. session 10.10.10.2-0.2-0.3-0.2-0.2-0.2-0.3-0.3-0.20.0-0.2-0.3-0.2-0.4-0.4-0.2
Total zone transitions, hab. session 10.50.71.40.80.80.70.80.80.80.90.8-1.20.81.00.80.90.90.8
Total locomotion distance, hab. session 12.63.85.02.02.01.92.02.02.02.02.0-0.92.02.22.02.02.02.0
Locomotion velocity, hab. session 11.11.62.21.31.31.21.31.31.31.31.3-1.01.31.51.31.31.31.3
Time in familiar zone, hab. session 20.30.30.40.50.60.60.60.50.50.60.50.40.50.60.50.60.50.6
Time in novel zone, hab. session 20.50.50.7-0.7-0.8-0.7-0.8-0.7-0.7-0.8-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.7
Total zone transitions, hab. session 20.00.00.1-0.0-0.0-0.1-0.0-0.1-0.1-0.0-0.1-0.3-0.1-0.0-0.1-0.1-0.2-0.1
Total locomotion distance, hab. session 20.40.60.80.80.80.80.80.80.80.80.8-0.40.80.90.80.70.70.8
Locomotion velocity, hab. session 20.40.50.70.80.80.70.80.70.80.80.7-0.40.70.80.70.60.60.8
Novel to familiar place preference ratio1.11.11.71.01.00.91.01.11.10.91.1-0.91.01.21.11.21.31.0
Novelty place preference0.91.01.50.90.90.90.91.01.00.91.0-0.61.01.11.01.21.21.0
Time in novel zone, NPP test0.60.60.90.70.70.70.70.80.80.60.8-0.80.80.90.80.91.00.7
Total zone transitions, NPP test0.20.20.3-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.5-0.5-0.5-0.4-0.4-0.6
Total locomotion distance, NPP test1.42.02.51.51.51.31.51.41.51.51.4-0.41.41.61.41.41.41.4
Locomotion velocity, NPP test1.92.63.31.71.71.61.71.71.71.71.7-0.21.71.81.71.71.61.6
Pavlov. Cond. lever latency0.20.20.3-0.5-0.5-0.4-0.5-0.4-0.4-0.5-0.4-0.5-0.4-0.4-0.4-0.5-0.5-0.4
Pavlov. Cond. magazine entry latency0.10.10.3-0.4-0.4-0.3-0.3-0.3-0.4-0.4-0.30.4-0.3-0.4-0.3-0.4-0.5-0.3
Pavlov. Cond. change in total contacts0.00.00.1-0.0-0.00.00.00.00.00.00.10.40.1-0.00.00.00.00.0
Pavlov. Cond. index score0.00.00.20.10.10.10.10.10.10.10.10.50.10.10.10.10.10.1
Pavlov. Cond. latency score0.10.10.30.20.20.20.30.30.20.30.30.50.30.20.30.30.20.2
Pavlov. Cond. lever contacts0.80.91.31.01.00.91.00.90.91.00.91.10.90.90.91.11.00.9
Pavlov. Cond. magazine entry number0.00.00.10.20.20.20.10.10.20.20.1-0.10.10.20.10.30.40.2
Pavlov. Cond. intertrial magazine entries0.10.10.7-0.3-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.9-0.3-0.2-0.4-0.3-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.30.30.30.40.30.30.40.30.70.30.30.30.40.30.3
Pavlov. Cond. response bias0.10.10.40.30.30.30.40.40.30.40.40.60.40.30.40.30.20.3
Bone: apparent density0.10.20.6-0.4-0.4-0.4-0.6-0.6-0.4-0.4-0.60.8-0.6-0.5-0.6-0.2-0.2-0.4
Bone surface0.20.42.80.50.50.60.40.30.50.50.31.70.30.40.30.70.80.5
Bone volume0.20.42.60.50.50.60.30.30.50.50.41.60.30.40.30.70.80.5
Bone: connectivity density0.61.01.2-1.1-1.1-1.0-1.1-1.1-1.0-1.1-1.10.2-1.1-1.1-1.1-0.8-0.8-1.1
Bone: cortical apparent density2.22.85.0-1.6-1.6-1.8-1.7-1.6-1.6-1.6-1.7-2.2-1.6-1.5-1.6-1.7-1.8-1.6
Bone: cortical area2.03.13.91.91.91.81.71.71.82.01.70.71.61.91.71.81.81.9
Bone: cortical porosity0.50.60.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.6-0.8-0.7-0.8-0.7-0.7-0.8
Bone: cortical porosity0.60.60.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.6-0.8-0.8-0.8-0.8-0.8-0.8
Bone: cortical thickness0.91.52.21.41.31.31.21.11.31.51.10.51.11.31.11.21.21.3
Bone: cortical thickness0.00.00.1-0.1-0.1-0.1-0.2-0.3-0.2-0.0-0.20.3-0.3-0.2-0.3-0.3-0.2-0.1
Bone: cortical tissue density2.53.35.0-1.7-1.8-1.9-1.8-1.7-1.8-1.7-1.8-2.2-1.7-1.7-1.7-1.8-1.9-1.8
Bone: elastic displacement0.10.10.2-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.30.1-0.3-0.3-0.3-0.2-0.2-0.2
Bone: elastic work2.22.93.21.71.71.81.61.61.71.71.61.71.61.71.61.71.71.8
Bone: endosteal estimation1.02.12.91.41.51.51.41.41.51.51.50.21.41.61.41.61.71.5
Bone: endosteal perimeter0.81.72.41.31.31.41.31.31.41.31.40.71.31.41.31.51.51.3
Bone: final force1.62.73.51.81.81.81.61.51.71.91.51.11.51.71.51.61.71.8
Bone: final moment2.54.15.12.12.12.22.01.92.12.21.91.51.92.11.92.02.12.2
Bone: marrow area1.02.23.01.51.51.51.51.41.61.51.50.21.41.71.41.71.71.6
Bone: maximum diameter1.32.53.01.61.61.61.51.51.61.71.51.61.51.51.51.71.71.6
Bone: maximum force2.74.65.82.32.32.32.12.12.32.42.10.92.02.32.12.12.22.3
Bone: maximum moment3.66.27.52.62.62.62.52.42.62.72.41.32.42.62.42.52.62.6
Bone: minimum diameter5.49.912.43.33.33.23.23.13.33.43.20.03.13.53.13.33.23.3
Bone: periosteal estimation1.83.84.72.02.02.01.91.82.12.11.90.51.82.21.82.22.12.1
Bone: periosteal perimeter1.62.63.21.71.71.71.61.61.71.71.60.51.61.81.61.71.81.7
Bone: post-yield work0.60.91.11.01.00.91.01.00.91.01.1-0.11.01.01.00.80.90.9
Bone: stiffness1.32.13.01.61.61.51.51.41.51.71.40.21.41.61.41.41.51.5
Bone: tissue strength4.44.24.72.12.12.12.12.22.12.12.11.22.22.12.22.12.12.1
Bone: trabecular number0.10.10.50.30.20.30.20.20.20.30.20.70.20.20.20.40.40.2
Bone: trabecular spacing1.72.22.71.51.51.51.61.51.51.51.60.01.51.61.51.51.51.6
Bone: trabecular thickness0.30.31.3-0.4-0.4-0.4-0.6-0.6-0.5-0.4-0.51.1-0.6-0.6-0.6-0.3-0.3-0.5
Bone: trabecular tissue density2.63.64.2-1.9-2.0-2.0-2.0-2.0-1.9-1.9-2.0-1.6-2.0-1.8-2.0-1.8-1.8-1.9
Breakpoint value in progressive ratio session1.31.42.21.31.21.11.11.01.21.21.1-1.30.91.51.01.21.11.3
Distance traveled before self-admin2.02.22.81.51.51.61.51.41.51.51.60.91.51.51.41.51.41.7
Distance traveled after self-admin5.35.87.02.42.42.52.52.42.42.42.61.72.52.42.42.52.42.6
Delta time in closed arm before/after self-admin0.50.52.30.50.50.50.60.60.60.50.71.50.50.50.60.70.80.6
Delta time in open arm before/after self-admin0.00.00.0-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Diff in mean of infusions in LGA sessions0.10.21.30.50.40.30.20.10.30.3-0.1-1.1-0.00.50.10.10.10.4
Extinction: sum of active levers before priming1.01.01.51.11.01.01.01.01.01.10.9-0.80.91.21.01.11.21.0
Active lever presses in extinction session 60.20.20.30.50.50.40.30.30.40.50.4-0.40.20.50.30.60.40.5
Delta distance traveled before/after self-admin0.30.40.50.60.60.60.50.60.60.60.70.40.60.60.60.70.70.6
Delta ambulatory time before/after self-admin1.01.11.31.11.11.01.11.21.11.01.20.51.11.11.21.01.11.1
Time in closed arm before self-admin0.00.00.3-0.00.0-0.10.0-0.0-0.1-0.0-0.1-0.30.2-0.1-0.0-0.3-0.5-0.1
Time in closed arm after self-admin0.30.31.90.40.50.40.60.50.40.30.61.40.60.20.50.20.20.4
Time in open arm before self-admin1.11.21.81.11.11.10.90.91.11.21.01.00.91.10.91.31.31.1
Time in open arm after self-admin0.91.01.71.11.01.10.80.81.11.20.9-0.10.81.20.81.31.31.1
Sum of active levers in priming session hrs 5-60.50.56.60.40.30.1-0.0-0.00.20.4-0.1-2.6-0.00.5-0.00.00.00.2
Time to tail flick, vehicle, before self-admin0.20.21.40.40.50.40.30.10.30.30.31.20.30.20.10.30.40.3
Time to tail flick, vehicle, after self-admin0.30.31.80.30.40.40.50.40.40.30.61.30.40.30.40.40.40.5
Time to tail flick, test, before self-admin0.00.00.10.30.30.20.10.10.20.20.20.00.00.20.10.10.20.2
Time to tail flick, test, after self-admin0.10.10.30.10.20.10.30.30.20.20.50.50.30.00.3-0.0-0.00.1
Delta time to tail flick, vehicle, before/after SA0.10.10.20.20.20.30.40.50.30.20.50.40.40.30.50.30.30.3
Delta time to tail flick, test, before/after SA0.00.00.1-0.1-0.00.00.10.10.00.00.10.40.1-0.10.10.0-0.10.0
Ambulatory time before self-admin1.11.21.61.11.11.21.11.01.11.01.20.51.11.11.01.11.01.3
Ambulatory time after self-admin5.46.07.12.52.52.62.52.52.52.42.61.72.42.52.52.42.42.7
Total heroin consumption1.61.93.81.51.41.31.21.11.31.51.2-2.01.01.71.11.31.31.4
Area under the delay curve0.00.00.40.00.0-0.0-0.1-0.2-0.1-0.0-0.2-0.6-0.20.0-0.2-0.1-0.1-0.1
Delay disc. indifference point, 0s delay0.40.41.20.60.60.50.60.70.60.50.5-1.10.60.80.70.60.60.6
Delay disc. indifference point, 16s delay0.90.91.11.01.01.11.10.91.01.01.10.90.90.90.90.90.90.9
Delay disc. indifference point, 2s delay0.10.10.2-0.2-0.2-0.3-0.3-0.3-0.2-0.1-0.4-0.5-0.3-0.2-0.3-0.3-0.2-0.3
Delay disc. indifference point, 24s delay0.80.81.31.01.01.10.70.50.91.00.41.20.50.90.51.11.11.1
Delay disc. indifference point, 4s delay0.00.00.10.10.10.10.20.10.10.10.2-0.20.20.20.10.20.20.2
Delay disc. indifference point, 8s delay1.31.43.1-1.0-1.0-1.1-1.2-1.3-1.1-1.0-1.3-1.7-1.2-0.9-1.3-1.1-1.1-1.1
Delay discount exponential model param0.00.00.2-0.1-0.1-0.00.10.20.0-0.10.20.40.2-0.10.20.00.00.0
Delay discount hyperbolic model param0.00.00.30.10.10.10.20.30.10.10.30.50.20.00.30.10.10.1
Fecal boli incidents, locomotor time 13.13.44.8-2.2-2.1-2.0-1.8-1.6-2.0-2.2-1.50.2-1.5-2.1-1.6-1.9-1.8-2.1
Change in fecal boli incidents, locomotor task0.50.52.90.60.60.40.60.50.50.50.6-1.70.60.70.50.40.50.5
Time >=10cm from walls, locomotor time 10.00.00.0-0.1-0.2-0.1-0.2-0.2-0.2-0.20.10.10.1-0.2-0.2-0.2-0.1-0.2
Bouts of movement, locomotor time 10.20.20.40.40.30.40.30.50.40.30.7-0.50.50.40.50.30.50.3
Total resting periods, locomotor time 10.10.10.50.20.20.30.20.40.20.20.7-0.20.40.20.40.30.30.2
Rest time, locomotor task time 10.10.10.3-0.3-0.3-0.2-0.1-0.0-0.2-0.40.20.60.1-0.4-0.0-0.2-0.2-0.3
Distance moved, locomotor task time 10.10.10.30.40.40.30.30.20.40.60.0-0.30.10.50.20.50.50.4
Vertical activity count, locomotor time 11.11.21.91.11.11.11.11.01.21.20.9-0.10.91.21.01.21.41.0
Time >=10cm from walls, locomotor time 20.00.00.20.20.20.2-0.0-0.00.20.3-0.1-0.5-0.00.2-0.0-0.00.20.2
Bouts of movement, locomotor time 20.30.30.7-0.5-0.6-0.4-0.6-0.4-0.5-0.5-0.20.7-0.4-0.8-0.4-0.8-0.6-0.6
Total resting periods, locomotor time 20.30.30.8-0.5-0.6-0.4-0.6-0.4-0.5-0.5-0.20.6-0.4-0.8-0.4-0.9-0.7-0.6
Rest time, locomotor task time 20.30.40.60.60.60.60.60.50.50.50.70.80.60.50.50.60.50.6
Distance moved, locomotor task time 20.10.11.4-0.2-0.2-0.3-0.2-0.2-0.2-0.1-0.3-1.2-0.2-0.0-0.2-0.1-0.1-0.1
Vertical activity count, locomotor time 20.20.21.40.20.20.10.20.30.30.30.1-1.20.20.50.30.40.50.3
Weight adjusted by age0.10.10.2-0.4-0.4-0.4-0.3-0.4-0.3-0.4-0.2-0.5-0.3-0.3-0.4-0.4-0.4-0.5
Seeking ratio, delayed vs. immediate footshock1.11.31.91.31.21.11.11.01.21.41.10.31.11.21.01.31.31.2
Locomotion in novel chamber0.50.62.6-0.8-0.8-0.9-0.7-0.6-0.7-0.8-0.6-1.6-0.6-0.6-0.6-0.6-0.6-0.8
Locomotion in novel chamber post-restriction0.00.00.00.20.10.10.00.0-0.00.20.00.10.00.10.00.2-0.10.1
Progressive ratio0.70.82.0-1.0-0.9-0.9-0.8-1.0-0.8-0.9-0.8-1.4-0.9-0.7-1.0-0.8-0.7-1.0
Food seeking constrained by brief footshock3.03.74.81.91.91.92.12.12.01.92.20.32.22.02.11.81.81.9
Seeking ratio, punishment vs. effort2.53.13.71.81.81.81.81.91.71.81.81.81.91.61.91.51.41.8
Run reversals in cocaine runway, females0.50.52.1-0.6-0.6-0.5-0.6-0.5-0.6-0.6-0.51.5-0.5-0.8-0.5-0.6-0.6-0.6
Run reversals in cocaine runway, males0.80.81.1-0.9-0.8-0.8-0.8-1.0-0.8-0.8-0.8-0.6-1.0-0.8-1.0-0.9-1.1-0.8
Latency to leave start box in cocaine runway0.20.20.7-0.3-0.3-0.2-0.6-0.8-0.4-0.3-0.7-0.2-0.8-0.2-0.8-0.3-0.2-0.3
Latency to leave start box in cocaine runway, F0.70.71.3-0.6-0.6-0.6-0.9-1.1-0.8-0.6-1.1-1.0-1.1-0.6-1.1-0.8-0.7-0.6
Latency to leave start box in cocaine runway, M0.10.10.6-0.00.00.10.1-0.00.1-0.10.10.8-0.00.1-0.00.30.30.1
Cd content in liver0.60.64.1-0.6-0.6-0.7-0.6-0.6-0.6-0.6-0.6-2.0-0.6-0.4-0.6-0.7-0.7-0.6
Co content in liver1.72.02.4-1.5-1.5-1.5-1.4-1.4-1.5-1.5-1.5-0.5-1.4-1.5-1.4-1.5-1.5-1.5
Cu content in liver1.41.74.11.31.31.41.31.31.31.31.22.01.31.11.31.11.11.3
Fe content in liver0.40.50.7-0.7-0.7-0.7-0.8-0.8-0.7-0.7-0.80.3-0.8-0.8-0.8-0.6-0.6-0.7
K content in liver0.80.81.70.90.91.00.90.90.90.90.91.30.90.70.90.80.80.9
Mg content in liver0.20.21.80.30.30.40.30.30.30.30.31.30.30.10.30.20.20.3
Mn content in liver0.70.80.90.90.90.90.91.00.90.90.90.11.00.91.00.80.80.9
Na content in liver5.35.66.52.42.42.42.42.42.42.42.41.62.42.42.42.52.52.4
Rb content in liver0.00.00.10.10.00.1-0.0-0.00.00.10.10.3-0.0-0.0-0.0-0.0-0.00.1
Se content in liver2.93.53.9-2.0-1.9-2.0-1.9-1.9-1.9-2.0-2.0-1.6-1.9-1.8-1.9-1.8-1.8-2.0
Sr content in liver0.60.50.6-0.8-0.8-0.8-0.7-0.7-0.8-0.8-0.8-0.1-0.7-0.8-0.7-0.8-0.8-0.8
Zn content in liver0.30.30.5-0.6-0.6-0.5-0.6-0.6-0.6-0.6-0.60.6-0.6-0.7-0.6-0.6-0.6-0.6