| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | isoform ratio | ENSRNOT00000095077 | 0.0270 | 0.0220 | 7.7e-03 | 0.012 | 0.005 | 0.000 | 0.005 | 1.6e-02 | 8.9e-02 | 3.4e-01 | 8.7e-02 |
| 2 | BLA | alternative polyA | ENSRNOT00000095077 | 0.0720 | 0.0530 | 1.2e-03 | 0.052 | 0.053 | 0.029 | 0.034 | 8.8e-04 | 8.3e-04 | 1.0e-02 | 6.0e-03 |
| 3 | BLA | isoform ratio | ENSRNOT00000095077 | 0.1300 | 0.0820 | 7.1e-06 | 0.075 | 0.097 | 0.085 | 0.085 | 7.9e-05 | 7.3e-06 | 2.8e-05 | 2.6e-05 |
| 4 | Brain | isoform ratio | ENSRNOT00000095077 | 0.0755 | 0.0505 | 1.5e-06 | 0.057 | 0.063 | 0.071 | 0.063 | 5.0e-06 | 1.6e-06 | 3.5e-07 | 1.7e-06 |
| 5 | IL | isoform ratio | ENSRNOT00000095077 | 0.2390 | 0.1460 | 9.3e-04 | 0.085 | 0.109 | 0.130 | 0.111 | 4.5e-03 | 1.4e-03 | 5.1e-04 | 1.3e-03 |
| 6 | Liver | isoform ratio | ENSRNOT00000117670 | 0.0277 | 0.0227 | 6.9e-03 | 0.018 | 0.015 | 0.015 | 0.015 | 3.5e-03 | 8.1e-03 | 6.9e-03 | 7.8e-03 |
| 7 | NAcc | isoform ratio | ENSRNOT00000095077 | 0.0589 | 0.0422 | 2.1e-04 | 0.039 | 0.042 | 0.036 | 0.036 | 6.3e-04 | 4.1e-04 | 1.1e-03 | 9.9e-04 |
| 8 | OFC | isoform ratio | ENSRNOT00000095077 | 0.1900 | 0.1200 | 1.4e-03 | 0.100 | 0.119 | 0.123 | 0.104 | 2.3e-03 | 9.2e-04 | 7.6e-04 | 2.0e-03 |
| 9 | PL | alternative polyA | ENSRNOT00000095077 | 0.0400 | 0.0310 | 3.3e-03 | 0.030 | 0.029 | 0.021 | 0.027 | 2.3e-03 | 2.6e-03 | 8.6e-03 | 3.9e-03 |
| 10 | PL | isoform ratio | ENSRNOT00000095077 | 0.0730 | 0.0500 | 3.9e-05 | 0.051 | 0.056 | 0.047 | 0.044 | 8.9e-05 | 4.5e-05 | 1.8e-04 | 2.9e-04 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pavlov. Cond. response bias | 13.7 | 18.9 | 28.6 | 5.3 | 3.6 | 4.2 | 5.2 | 4.7 | 2.5 | 3.7 | 4.4 | 4.3 | 4.8 |
| Pavlov. Cond. lever latency | 12.2 | 16.7 | 26.7 | -5.2 | -3.2 | -3.8 | -4.9 | -4.4 | -2.7 | -3.4 | -4.1 | -4.0 | -4.5 |
| Pavlov. Cond. change in total contacts | 11.8 | 16.5 | 24.3 | 4.9 | 3.4 | 3.9 | 4.8 | 4.3 | 2.2 | 3.5 | 4.2 | 4.1 | 4.5 |
| Pavlov. Cond. lever contacts | 11.8 | 16.4 | 28.6 | 5.3 | 3.1 | 3.7 | 4.9 | 4.3 | 2.8 | 3.3 | 4.0 | 3.9 | 4.4 |
| Pavlov. Cond. index score | 11.1 | 14.5 | 20.1 | 4.3 | 3.3 | 3.8 | 4.5 | 4.2 | 2.0 | 3.4 | 4.0 | 3.8 | 4.2 |
| Pavlov. Cond. latency score | 11.1 | 14.0 | 18.8 | 4.0 | 3.4 | 3.8 | 4.3 | 4.1 | 1.7 | 3.5 | 4.0 | 3.8 | 4.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 10.6 | 13.7 | 18.9 | 4.3 | 3.2 | 3.6 | 4.3 | 4.0 | 2.1 | 3.3 | 3.8 | 3.7 | 4.1 |
| Pavlov. Cond. magazine entry number | 9.1 | 11.2 | 14.5 | -3.0 | -3.3 | -3.5 | -3.8 | -3.7 | -0.6 | -3.4 | -3.6 | -3.6 | -3.8 |
| Condit. Reinf. lever presses | 8.8 | 12.2 | 24.2 | 4.9 | 2.4 | 3.1 | 4.3 | 3.6 | 2.9 | 2.6 | 3.3 | 3.2 | 3.8 |
| Pavlov. Cond. magazine entry latency | 7.4 | 8.6 | 10.8 | 2.1 | 3.1 | 3.2 | 3.1 | 3.3 | 0.2 | 3.1 | 3.3 | 3.1 | 3.3 |
| Bone: trabecular tissue density | 5.8 | 8.1 | 10.8 | -0.6 | -3.3 | -3.2 | -2.7 | -3.0 | 2.3 | -3.3 | -3.1 | -3.2 | -2.9 |
| Liver weight, right | 5.4 | 8.9 | 11.6 | -0.9 | -3.4 | -3.3 | -2.9 | -3.0 | 2.6 | -3.3 | -3.2 | -3.4 | -3.0 |
| Degree of sensitization stereotypy | 4.7 | 5.1 | 8.2 | 2.8 | 1.8 | 2.2 | 2.9 | 2.4 | 0.2 | 1.9 | 2.2 | 2.5 | 2.5 |
| Liver weight, left | 4.3 | 7.0 | 8.6 | -1.6 | -2.9 | -2.9 | -2.7 | -2.7 | 1.7 | -2.9 | -2.9 | -2.9 | -2.8 |
| Delay discounting water rate 12 sec | 4.0 | 6.0 | 7.8 | 1.4 | 2.7 | 2.8 | 2.4 | 2.7 | -0.1 | 2.8 | 2.8 | 2.6 | 2.8 |
| Condit. Reinf. lever reinforcers received | 4.0 | 5.7 | 16.9 | 4.1 | 1.0 | 1.6 | 2.9 | 2.1 | 3.2 | 1.2 | 1.8 | 1.8 | 2.3 |
| Total sessions with >9 infusions | 3.8 | 4.2 | 5.9 | 1.5 | 2.0 | 2.2 | 2.4 | 2.3 | -0.3 | 2.1 | 2.2 | 2.3 | 2.3 |
| Median of all reaction times | 3.6 | 4.8 | 6.3 | -2.1 | -2.2 | -2.3 | -2.5 | -2.3 | 0.6 | -2.2 | -2.3 | -2.4 | -2.4 |
| Condit. Reinf. active responses | 3.6 | 5.0 | 15.4 | 3.9 | 0.8 | 1.4 | 2.7 | 1.9 | 3.3 | 1.0 | 1.6 | 1.6 | 2.1 |
| Zn content in liver | 3.4 | 3.7 | 5.1 | 1.7 | 1.9 | 2.0 | 2.3 | 2.1 | 0.3 | 1.9 | 2.1 | 2.1 | 2.2 |
| Condit. Reinf. active minus inactive responses | 3.3 | 4.0 | 11.1 | 3.3 | 0.9 | 1.4 | 2.4 | 1.9 | 2.6 | 1.1 | 1.6 | 1.5 | 2.0 |
| Cocaine induced anxiety | 3.3 | 3.8 | 5.6 | -1.7 | -1.9 | -2.1 | -2.4 | -2.3 | -0.5 | -2.0 | -2.1 | -1.5 | -2.3 |
| Context. condit. distance diff. score | 3.3 | 4.0 | 5.8 | 2.0 | 1.8 | 2.0 | 2.4 | 2.3 | 0.7 | 1.9 | 2.1 | 2.0 | 2.3 |
| Locomotion distance, session 8 | 3.3 | 4.9 | 6.4 | 1.9 | 2.2 | 2.3 | 2.5 | 2.5 | 0.7 | 2.2 | 2.4 | 2.2 | 2.5 |
| Time in closed arm before self-admin | 3.3 | 3.7 | 5.0 | 1.5 | 2.0 | 2.1 | 2.1 | 2.1 | -0.3 | 2.0 | 2.2 | 2.0 | 2.2 |
| Delay discounting water rate 18 sec | 3.2 | 4.2 | 5.3 | 2.0 | 1.9 | 2.1 | 2.3 | 2.3 | 1.2 | 2.0 | 2.2 | 2.0 | 2.3 |
| Bone: stiffness | 3.2 | 5.0 | 7.1 | -0.3 | -2.7 | -2.5 | -2.0 | -2.4 | 1.5 | -2.6 | -2.5 | -2.5 | -2.3 |
| Diff in mean of infusions in LGA sessions | 3.1 | 3.5 | 5.0 | -1.1 | -2.1 | -2.1 | -1.9 | -2.2 | -0.4 | -2.1 | -2.2 | -1.3 | -2.2 |
| Active lever presses in extinction session 6 | 3.1 | 2.9 | 4.5 | 1.3 | 1.7 | 1.8 | 1.9 | 1.8 | -0.9 | 1.7 | 1.8 | 2.1 | 1.7 |
| Time in open arm before self-admin | 3.1 | 3.3 | 7.8 | -2.8 | -1.2 | -1.6 | -2.2 | -1.9 | -1.4 | -1.3 | -1.8 | -1.6 | -1.9 |
| Reaction time num false alarms | 3.0 | 4.2 | 5.9 | -1.8 | -2.0 | -2.1 | -2.4 | -2.3 | 0.1 | -2.0 | -2.2 | -2.3 | -2.2 |
| Reaction time mean AUC | 3.0 | 4.0 | 5.1 | -1.7 | -2.0 | -2.2 | -2.3 | -2.1 | 0.7 | -2.1 | -2.1 | -2.2 | -2.2 |
| Intermittent access intake day 1-15 change | 3.0 | 2.9 | 4.1 | 0.9 | 1.9 | 1.9 | 1.7 | 1.8 | -0.9 | 1.9 | 1.8 | 2.0 | 1.8 |
| Cocaine response before conditioning | 2.9 | 3.6 | 4.4 | 1.0 | 2.0 | 2.1 | 2.0 | 2.1 | -0.9 | 2.1 | 2.1 | 2.0 | 2.0 |
| Total zone transitions, hab. session 2 | 2.9 | 3.8 | 5.2 | 2.0 | 1.8 | 2.0 | 2.3 | 2.1 | 0.0 | 1.9 | 2.1 | 2.1 | 2.2 |
| Reaction time mean | 2.8 | 3.8 | 4.8 | -1.6 | -2.0 | -2.1 | -2.2 | -2.0 | 0.9 | -2.0 | -2.1 | -2.2 | -2.1 |
| Intermittent access intake escalation | 2.7 | 2.7 | 3.8 | 0.6 | 1.9 | 1.8 | 1.5 | 1.7 | -1.0 | 1.9 | 1.8 | 2.0 | 1.7 |
| Stereotopy head waving duration, day 7 | 2.7 | 3.3 | 5.1 | 2.2 | 1.5 | 1.8 | 2.3 | 1.9 | -0.0 | 1.6 | 1.8 | 2.0 | 2.0 |
| Se content in liver | 2.7 | 3.3 | 6.9 | -2.6 | -1.3 | -1.6 | -2.1 | -1.9 | -1.6 | -1.4 | -1.8 | -1.6 | -1.9 |
| Number of licking bursts | 2.6 | 3.1 | 5.5 | -2.3 | -1.3 | -1.6 | -2.2 | -1.9 | -0.9 | -1.4 | -1.8 | -1.8 | -1.9 |
| Food consumed during 24 hour testing period | 2.6 | 3.1 | 4.5 | 1.8 | 1.6 | 1.8 | 2.1 | 1.9 | -0.1 | 1.7 | 1.9 | 1.9 | 2.0 |
| Light reinforcement 2 | 2.6 | 3.5 | 5.5 | -0.6 | 2.3 | 2.1 | 1.3 | 1.8 | -2.1 | 2.3 | 1.9 | 1.9 | 1.7 |
| Sr content in liver | 2.6 | 2.4 | 3.4 | 0.1 | 1.8 | 1.7 | 1.3 | 1.6 | -1.2 | 1.8 | 1.7 | 1.7 | 1.6 |
| Delay discounting time to switch 0 sec | 2.4 | 3.7 | 7.3 | -2.7 | -1.5 | -1.8 | -2.2 | -2.0 | -1.3 | -1.6 | -1.9 | -1.7 | -2.1 |
| Reaction time num false alarms AUC | 2.4 | 3.4 | 4.7 | -1.8 | -1.7 | -1.9 | -2.2 | -2.0 | -0.2 | -1.7 | -1.9 | -2.0 | -2.0 |
| Reaction time false alarm rate | 2.4 | 3.4 | 4.8 | -1.8 | -1.7 | -1.9 | -2.2 | -2.0 | 0.0 | -1.7 | -1.9 | -2.1 | -2.0 |
| Intermitt. access day 1 inactive lever presses | 2.4 | 2.6 | 3.5 | -1.2 | -1.7 | -1.8 | -1.8 | -1.9 | 0.2 | -1.7 | -1.8 | -1.6 | -1.8 |
| Total resting periods, locomotor time 2 | 2.4 | 2.5 | 3.8 | -0.3 | -1.9 | -1.8 | -1.4 | -1.7 | 1.0 | -1.9 | -1.8 | -1.6 | -1.6 |
| Conditioned locomotion | 2.3 | 2.8 | 4.4 | 1.2 | 1.7 | 1.8 | 1.9 | 1.8 | -0.7 | 1.7 | 1.7 | 2.1 | 1.7 |
| Stereotopy head waving bouts, day 7 | 2.3 | 2.6 | 4.5 | 2.1 | 1.3 | 1.6 | 2.1 | 1.7 | -0.0 | 1.4 | 1.6 | 1.8 | 1.8 |
| Delta time in closed arm before/after self-admin | 2.2 | 2.1 | 2.9 | -0.6 | -1.5 | -1.6 | -1.6 | -1.5 | 1.0 | -1.6 | -1.6 | -1.7 | -1.5 |
| Delay disc. indifference point, 24s delay | 2.2 | 2.2 | 2.9 | -1.2 | -1.5 | -1.6 | -1.6 | -1.7 | 0.3 | -1.6 | -1.7 | -1.1 | -1.7 |
| Bouts of movement, locomotor time 2 | 2.2 | 2.4 | 3.9 | 0.1 | -2.0 | -1.8 | -1.1 | -1.6 | 1.4 | -1.9 | -1.7 | -1.5 | -1.5 |
| Post-drug Anxiety | 2.1 | 2.4 | 3.5 | -0.0 | -1.9 | -1.8 | -1.5 | -1.8 | 0.7 | -1.9 | -1.8 | -1.2 | -1.7 |
| Mean num. licks in bursts | 1.9 | 2.2 | 4.4 | 2.1 | 1.1 | 1.3 | 1.9 | 1.5 | 1.0 | 1.1 | 1.5 | 1.5 | 1.6 |
| Bone: cortical apparent density | 1.9 | 2.5 | 3.6 | -1.2 | -1.5 | -1.6 | -1.9 | -1.7 | 0.8 | -1.5 | -1.6 | -1.8 | -1.6 |
| Mean time between licks in bursts | 1.8 | 2.5 | 13.0 | 3.1 | -0.7 | -0.2 | 1.1 | 0.3 | 3.6 | -0.6 | 0.1 | -0.0 | 0.5 |
| Bone: cortical tissue density | 1.8 | 2.4 | 3.5 | -1.2 | -1.5 | -1.6 | -1.9 | -1.7 | 0.7 | -1.5 | -1.6 | -1.8 | -1.6 |
| Bone: trabecular thickness | 1.8 | 2.2 | 3.4 | 0.0 | -1.8 | -1.7 | -1.2 | -1.5 | 1.2 | -1.8 | -1.6 | -1.6 | -1.5 |
| Tail length | 1.7 | 5.2 | 25.4 | 4.4 | -1.6 | -0.8 | 1.2 | 0.0 | 5.0 | -1.4 | -0.5 | -0.5 | 0.1 |
| Delay discounting water rate 0 sec | 1.7 | 2.7 | 5.6 | 2.4 | 1.3 | 1.6 | 1.9 | 1.7 | 0.8 | 1.4 | 1.6 | 1.5 | 1.8 |
| Locomotion distance, session 1 | 1.7 | 2.2 | 2.8 | 0.6 | 1.7 | 1.7 | 1.5 | 1.7 | -0.6 | 1.7 | 1.6 | 1.6 | 1.6 |
| Degree of sensitization distance | 1.7 | 1.7 | 3.4 | -0.4 | -1.3 | -1.3 | -1.3 | -1.2 | 1.8 | -1.3 | -1.2 | -1.6 | -1.2 |
| Pavlov. Cond. magazine entry latency | 1.7 | 2.2 | 4.1 | 2.0 | 1.0 | 1.2 | 1.8 | 1.5 | 1.4 | 1.1 | 1.4 | 1.3 | 1.6 |
| Delay disc. indifference point, 16s delay | 1.7 | 1.8 | 2.5 | -0.5 | -1.6 | -1.5 | -1.2 | -1.5 | 0.5 | -1.6 | -1.6 | -1.2 | -1.5 |
| Delay discounting water rate 6 sec | 1.6 | 2.4 | 3.1 | 0.9 | 1.7 | 1.7 | 1.4 | 1.8 | -0.0 | 1.7 | 1.8 | 1.6 | 1.7 |
| Locomotor testing distance | 1.6 | 2.6 | 3.6 | 1.9 | 1.4 | 1.6 | 1.8 | 1.8 | 1.3 | 1.5 | 1.6 | 1.5 | 1.8 |
| Condit. Reinf. inactive responses | 1.6 | 2.0 | 7.7 | 2.8 | 0.1 | 0.5 | 1.5 | 0.9 | 2.6 | 0.2 | 0.7 | 0.7 | 1.0 |
| Retroperitoneal fat weight | 1.5 | 4.8 | 6.7 | -1.9 | -2.0 | -2.2 | -2.6 | -2.2 | 2.0 | -2.1 | -2.1 | -2.6 | -2.2 |
| Indifference point 0 sec | 1.5 | 2.5 | 4.6 | 2.1 | 1.3 | 1.5 | 1.8 | 1.5 | 0.7 | 1.4 | 1.6 | 1.6 | 1.7 |
| Short access day 1 locomotion | 1.5 | 1.6 | 2.1 | 0.4 | 1.4 | 1.4 | 1.4 | 1.4 | -1.2 | 1.4 | 1.3 | 1.2 | 1.3 |
| Novel to familiar place preference ratio | 1.5 | 1.6 | 2.5 | 0.4 | -1.6 | -1.4 | -0.9 | -1.3 | 1.2 | -1.5 | -1.3 | -1.3 | -1.2 |
| Pavlov. Cond. magazine entry number | 1.5 | 1.9 | 3.5 | -1.9 | -0.9 | -1.2 | -1.8 | -1.4 | -1.0 | -1.0 | -1.3 | -1.3 | -1.5 |
| Bone: final force | 1.5 | 2.5 | 3.5 | -0.4 | -1.9 | -1.8 | -1.5 | -1.7 | 1.1 | -1.9 | -1.8 | -1.7 | -1.6 |
| Bone: trabecular spacing | 1.5 | 1.9 | 2.5 | 0.8 | 1.6 | 1.6 | 1.4 | 1.4 | -0.3 | 1.6 | 1.6 | 1.4 | 1.5 |
| Delay discounting total patch changes 0 sec | 1.4 | 2.3 | 3.8 | 2.0 | 1.3 | 1.5 | 1.7 | 1.5 | 0.6 | 1.4 | 1.6 | 1.6 | 1.7 |
| Total zone transitions, NPP test | 1.4 | 2.0 | 2.9 | 0.1 | 1.7 | 1.6 | 1.2 | 1.5 | -1.2 | 1.7 | 1.5 | 1.5 | 1.4 |
| Bone: tissue strength | 1.4 | 1.4 | 3.6 | -0.7 | 1.4 | 1.2 | 0.6 | 1.0 | -1.9 | 1.4 | 1.1 | 1.0 | 0.9 |
| Distance moved, locomotor task time 2 | 1.4 | 1.7 | 4.2 | 2.1 | 0.7 | 1.0 | 1.3 | 1.2 | 1.5 | 0.8 | 1.1 | 1.4 | 1.3 |
| Std. dev. reaction times | 1.3 | 1.7 | 2.5 | -0.1 | -1.5 | -1.5 | -1.1 | -1.2 | 1.6 | -1.5 | -1.4 | -1.4 | -1.3 |
| Locomotion distance, session 2 | 1.3 | 1.8 | 2.7 | 0.3 | 1.6 | 1.5 | 1.2 | 1.6 | -0.2 | 1.6 | 1.5 | 1.3 | 1.5 |
| Novelty place preference | 1.3 | 1.4 | 2.1 | 0.4 | -1.5 | -1.3 | -0.8 | -1.2 | 1.2 | -1.4 | -1.2 | -1.3 | -1.1 |
| Latency to leave start box in cocaine runway, F | 1.3 | 1.4 | 2.1 | -0.9 | -1.4 | -1.4 | -1.0 | -1.4 | -0.2 | -1.4 | -1.3 | -0.6 | -1.4 |
| Length with tail | 1.2 | 4.4 | 22.4 | 3.0 | -2.0 | -1.4 | 0.1 | -0.7 | 4.7 | -1.8 | -1.1 | -1.3 | -0.6 |
| Delay discounting water rate 24 sec | 1.2 | 1.7 | 2.4 | 0.4 | 1.5 | 1.5 | 1.2 | 1.4 | -0.4 | 1.5 | 1.5 | 1.3 | 1.4 |
| Intermittent access day 15 total locomotion | 1.2 | 1.3 | 1.6 | 0.8 | 1.2 | 1.2 | 1.2 | 1.2 | -0.9 | 1.2 | 1.2 | 1.3 | 1.2 |
| Locomotion distance, session 3 | 1.2 | 1.3 | 2.1 | 0.9 | 1.0 | 1.2 | 1.4 | 1.3 | -0.6 | 1.1 | 1.1 | 1.4 | 1.2 |
| Time in novel zone, NPP test | 1.2 | 1.3 | 2.0 | 0.6 | -1.4 | -1.2 | -0.7 | -1.1 | 1.4 | -1.4 | -1.1 | -1.2 | -1.0 |
| Bone: elastic work | 1.2 | 1.5 | 8.6 | -2.0 | 1.0 | 0.6 | -0.3 | 0.2 | -2.9 | 0.8 | 0.4 | 0.5 | 0.1 |
| Fecal boli incidents, locomotor time 1 | 1.2 | 1.3 | 2.0 | -1.4 | -1.0 | -1.1 | -0.8 | -1.4 | -1.0 | -1.1 | -1.2 | -0.3 | -1.3 |
| Locomotion in novel chamber post-restriction | 1.2 | 1.5 | 2.1 | 0.5 | 1.3 | 1.3 | 1.5 | 1.1 | -0.9 | 1.3 | 1.4 | 1.2 | 1.3 |
| Condit. Reinf. active-inactive response ratio | 1.1 | 1.2 | 1.8 | 1.3 | 0.9 | 1.0 | 1.3 | 1.2 | 0.7 | 0.9 | 1.1 | 1.0 | 1.2 |
| Pavlov. Cond. intertrial magazine entries | 1.1 | 1.4 | 2.3 | 0.5 | -1.4 | -1.3 | -0.7 | -1.1 | 1.5 | -1.4 | -1.2 | -1.2 | -1.0 |
| Short access day 1 total inactive lever presses | 1.1 | 1.2 | 1.8 | -0.5 | -1.3 | -1.3 | -0.9 | -1.3 | -0.2 | -1.3 | -1.3 | -0.7 | -1.3 |
| Bone: final moment | 1.1 | 1.8 | 2.6 | -0.1 | -1.6 | -1.5 | -1.1 | -1.4 | 1.1 | -1.6 | -1.5 | -1.5 | -1.3 |
| Time to tail flick, vehicle, after self-admin | 1.1 | 1.1 | 2.4 | 1.4 | 0.7 | 0.9 | 1.4 | 1.1 | -0.2 | 0.8 | 1.0 | 1.6 | 1.1 |
| Rest time, locomotor task time 2 | 1.1 | 1.3 | 3.7 | -1.9 | -0.6 | -0.9 | -1.4 | -1.0 | -1.2 | -0.7 | -1.0 | -0.9 | -1.1 |
| Social responses | 1.0 | 1.3 | 1.7 | -0.3 | -1.1 | -1.2 | -1.2 | -1.2 | 1.1 | -1.2 | -1.1 | -1.3 | -1.1 |
| Social time | 1.0 | 1.2 | 3.9 | -2.0 | -0.6 | -0.8 | -1.2 | -1.1 | -1.4 | -0.6 | -0.9 | -0.8 | -1.1 |
| Conditioned locomotion | 1.0 | 1.2 | 1.7 | -0.6 | -1.2 | -1.2 | -1.1 | -1.1 | 0.7 | -1.2 | -1.2 | -1.3 | -1.2 |
| Conditioned reinforcement - inactives | 1.0 | 1.2 | 1.6 | -0.5 | -1.2 | -1.3 | -1.0 | -1.2 | 0.5 | -1.3 | -1.3 | -0.9 | -1.2 |
| Delta ambulatory time before/after self-admin | 1.0 | 1.0 | 3.2 | 1.8 | 0.4 | 0.6 | 1.3 | 0.8 | 1.2 | 0.4 | 0.7 | 1.1 | 0.9 |
| Total heroin consumption | 1.0 | 1.3 | 1.6 | 0.8 | 1.1 | 1.2 | 1.2 | 1.3 | 0.7 | 1.2 | 1.2 | 1.2 | 1.3 |
| Area under the delay curve | 1.0 | 1.1 | 1.5 | -0.7 | -1.1 | -1.2 | -1.0 | -1.2 | 0.2 | -1.1 | -1.2 | -0.9 | -1.2 |
| Std. dev. time between licks in bursts | 0.9 | 1.1 | 5.4 | 1.2 | -1.1 | -0.8 | -0.1 | -0.5 | 2.3 | -1.0 | -0.6 | -0.8 | -0.4 |
| One hour access (0.3 mA shock) | 0.9 | 1.0 | 1.4 | 0.8 | 1.0 | 1.1 | 1.1 | 1.2 | 0.7 | 1.0 | 1.1 | 1.0 | 1.1 |
| Number of responses in last shaping day | 0.9 | 1.0 | 1.5 | -0.0 | -1.2 | -1.1 | -0.9 | -0.9 | 0.7 | -1.2 | -1.1 | -1.1 | -1.0 |
| Locomotion velocity, session 2 | 0.9 | 1.0 | 1.7 | 0.0 | 1.3 | 1.2 | 0.8 | 1.1 | -0.4 | 1.3 | 1.2 | 0.9 | 1.1 |
| Locomotion velocity, session 8 | 0.9 | 1.1 | 1.7 | 1.3 | 0.8 | 1.0 | 1.3 | 1.2 | 0.8 | 0.9 | 1.1 | 0.9 | 1.2 |
| Condit. Reinf. active-inactive response ratio | 0.9 | 1.0 | 2.7 | 1.3 | -1.2 | -0.9 | -0.1 | -0.7 | 1.7 | -1.1 | -0.8 | -0.7 | -0.6 |
| Time in familiar zone, hab. session 2 | 0.9 | 0.9 | 3.9 | 2.0 | -0.1 | 0.3 | 0.9 | 0.6 | 1.9 | 0.0 | 0.4 | 0.3 | 0.6 |
| Pavlov. Cond. index score | 0.9 | 1.1 | 2.8 | 1.7 | 0.5 | 0.8 | 1.4 | 1.0 | 1.1 | 0.6 | 0.9 | 0.9 | 1.1 |
| Distance traveled after self-admin | 0.9 | 1.0 | 2.2 | 0.3 | 1.1 | 1.1 | 1.0 | 1.1 | -0.2 | 1.1 | 1.1 | 1.5 | 1.0 |
| Delta distance traveled before/after self-admin | 0.9 | 1.0 | 3.5 | 1.9 | 0.1 | 0.4 | 1.2 | 0.6 | 1.6 | 0.2 | 0.6 | 0.9 | 0.7 |
| Delay discount exponential model param | 0.9 | 1.0 | 1.3 | 0.9 | 1.0 | 1.1 | 1.0 | 1.2 | -0.1 | 1.0 | 1.1 | 0.8 | 1.1 |
| Time >=10cm from walls, locomotor time 2 | 0.9 | 1.0 | 4.5 | 2.1 | -0.4 | -0.1 | 0.5 | 0.3 | 2.1 | -0.3 | 0.1 | 0.4 | 0.3 |
| Latency to leave start box in cocaine runway | 0.9 | 1.0 | 1.7 | -1.3 | -1.0 | -1.1 | -0.8 | -1.2 | -0.9 | -1.0 | -1.0 | -0.3 | -1.2 |
| Co content in liver | 0.9 | 1.1 | 4.3 | 1.8 | -1.1 | -0.7 | 0.2 | -0.4 | 2.1 | -1.0 | -0.6 | -0.6 | -0.3 |
| Cocaine response after cond. corrected | 0.8 | 0.9 | 1.5 | -1.2 | -0.7 | -0.9 | -1.2 | -1.0 | -0.1 | -0.8 | -0.9 | -0.9 | -1.1 |
| Total locomotion distance, hab. session 1 | 0.8 | 1.2 | 2.3 | 0.1 | -1.2 | -1.2 | -1.0 | -1.1 | 1.5 | -1.2 | -1.0 | -1.2 | -1.0 |
| Pavlov. Cond. intertrial magazine entries | 0.8 | 0.9 | 1.4 | -1.0 | -0.9 | -1.0 | -1.2 | -1.1 | -0.4 | -0.9 | -1.0 | -0.9 | -1.1 |
| Delta time in open arm before/after self-admin | 0.8 | 0.8 | 3.5 | 1.9 | 0.1 | 0.4 | 1.0 | 0.7 | 1.0 | 0.2 | 0.6 | 0.7 | 0.7 |
| Time to tail flick, test, after self-admin | 0.8 | 0.9 | 3.4 | 1.7 | -0.9 | -0.6 | 0.1 | -0.4 | 1.8 | -0.8 | -0.5 | -0.3 | -0.2 |
| Ambulatory time after self-admin | 0.8 | 0.9 | 2.3 | 0.5 | 0.8 | 0.9 | 1.2 | 1.0 | -0.2 | 0.8 | 0.8 | 1.5 | 0.9 |
| Saline control response | 0.7 | 0.9 | 4.1 | 2.0 | -0.5 | -0.1 | 0.7 | 0.2 | 2.0 | -0.4 | 0.0 | 0.0 | 0.3 |
| Short access day 1 total infusions | 0.7 | 0.8 | 1.8 | 1.4 | 0.4 | 0.6 | 1.2 | 0.8 | 1.0 | 0.4 | 0.6 | 0.8 | 0.8 |
| Short access total infusions | 0.7 | 0.8 | 1.7 | 1.3 | 0.5 | 0.7 | 1.2 | 0.9 | 0.8 | 0.6 | 0.7 | 0.9 | 0.9 |
| Locomotion velocity, session 1 | 0.7 | 0.8 | 2.4 | -0.8 | 1.0 | 0.8 | 0.3 | 0.7 | -1.5 | 1.0 | 0.7 | 0.7 | 0.6 |
| Condit. Reinf. active responses | 0.7 | 0.8 | 1.3 | 0.4 | -1.1 | -1.0 | -0.6 | -0.9 | 1.0 | -1.1 | -1.0 | -0.9 | -0.8 |
| Time in novel zone, hab. session 1 | 0.7 | 0.7 | 0.9 | -0.4 | -0.9 | -0.9 | -0.9 | -0.9 | 0.0 | -0.9 | -0.9 | -0.8 | -0.9 |
| Time in novel zone, hab. session 2 | 0.7 | 0.7 | 3.0 | -1.4 | 0.9 | 0.6 | -0.0 | 0.3 | -1.7 | 0.8 | 0.5 | 0.5 | 0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.9 | 2.3 | 1.5 | 0.5 | 0.8 | 1.3 | 1.0 | 0.8 | 0.6 | 0.8 | 0.8 | 1.0 |
| Bone: connectivity density | 0.7 | 1.0 | 3.7 | -0.6 | 1.1 | 1.0 | 0.6 | 0.8 | -1.9 | 1.1 | 0.8 | 0.9 | 0.7 |
| Bone: maximum force | 0.7 | 1.2 | 1.8 | -0.1 | -1.4 | -1.3 | -1.0 | -1.1 | 0.8 | -1.3 | -1.2 | -1.2 | -1.1 |
| Bone: minimum diameter | 0.7 | 1.2 | 5.3 | 1.0 | -1.2 | -0.9 | -0.3 | -0.6 | 2.3 | -1.1 | -0.8 | -0.9 | -0.6 |
| Delay discount hyperbolic model param | 0.7 | 0.8 | 1.1 | 0.6 | 1.0 | 1.0 | 0.8 | 1.0 | -0.3 | 1.0 | 1.1 | 0.7 | 1.0 |
| Seeking ratio, delayed vs. immediate footshock | 0.7 | 0.8 | 2.5 | -1.4 | -0.2 | -0.4 | -1.2 | -0.7 | -1.6 | -0.2 | -0.5 | -0.6 | -0.7 |
| Locomotion in novel chamber | 0.7 | 0.8 | 2.6 | -1.0 | 1.1 | 0.9 | 0.3 | 0.6 | -1.6 | 1.0 | 0.8 | 0.5 | 0.6 |
| Fe content in liver | 0.7 | 0.8 | 1.3 | 0.0 | -1.1 | -1.0 | -0.8 | -1.0 | 0.4 | -1.1 | -1.0 | -1.1 | -1.0 |
| Mn content in liver | 0.7 | 0.8 | 3.7 | -1.9 | 0.1 | -0.2 | -0.8 | -0.4 | -1.7 | 0.0 | -0.3 | -0.2 | -0.5 |
| BMI with tail | 0.6 | 1.8 | 3.7 | -0.8 | 1.9 | 1.6 | 0.5 | 1.3 | -0.7 | 1.8 | 1.5 | 1.2 | 1.3 |
| BMI without tail | 0.6 | 1.2 | 1.8 | 1.4 | 0.9 | 1.0 | 1.1 | 1.1 | 1.3 | 1.0 | 1.1 | 0.9 | 1.2 |
| Delay discounting total patch changes 6 sec | 0.6 | 0.9 | 2.3 | 1.5 | 0.8 | 0.9 | 1.1 | 0.9 | 0.1 | 0.8 | 0.9 | 0.9 | 1.0 |
| Locomotor activity | 0.6 | 0.9 | 1.2 | 1.0 | 1.0 | 1.0 | 1.0 | 1.1 | 0.5 | 1.0 | 1.0 | 0.9 | 1.1 |
| Baseline Anxiety | 0.6 | 0.6 | 3.3 | 1.8 | 0.0 | 0.3 | 0.8 | 0.5 | 1.2 | 0.1 | 0.4 | -0.1 | 0.6 |
| Short access day 10 total inactive lever presses | 0.6 | 0.6 | 1.1 | -0.9 | -0.6 | -0.8 | -1.0 | -0.9 | -0.5 | -0.7 | -0.8 | -0.6 | -0.9 |
| Stereotopy head waving bouts, day 3 | 0.6 | 0.7 | 1.0 | 0.1 | -0.9 | -0.9 | -0.7 | -0.8 | 0.8 | -0.9 | -0.8 | -1.0 | -0.8 |
| Total zone transitions, hab. session 1 | 0.6 | 0.8 | 1.1 | 0.3 | 1.0 | 1.0 | 1.0 | 0.9 | -0.9 | 1.0 | 0.9 | 1.0 | 0.9 |
| Locomotion velocity, hab. session 1 | 0.6 | 0.8 | 1.6 | -0.1 | -0.9 | -0.9 | -0.8 | -0.9 | 1.3 | -1.0 | -0.8 | -1.0 | -0.8 |
| Total locomotion distance, hab. session 2 | 0.6 | 0.7 | 5.6 | 1.1 | -0.4 | -0.3 | -0.0 | -0.1 | 2.4 | -0.4 | -0.1 | -0.4 | 0.0 |
| Locomotion velocity, hab. session 2 | 0.6 | 0.8 | 5.8 | 1.0 | -0.5 | -0.4 | -0.2 | -0.2 | 2.4 | -0.5 | -0.3 | -0.5 | -0.1 |
| Pavlov. Cond. latency score | 0.6 | 0.8 | 2.5 | 1.6 | 0.3 | 0.6 | 1.2 | 0.8 | 1.1 | 0.4 | 0.7 | 0.7 | 0.9 |
| Bone: elastic displacement | 0.6 | 0.7 | 3.6 | -1.6 | 0.4 | 0.1 | -0.5 | -0.2 | -1.9 | 0.3 | -0.0 | 0.0 | -0.3 |
| Food seeking constrained by brief footshock | 0.6 | 0.8 | 2.5 | 1.6 | 0.2 | 0.4 | 1.0 | 0.6 | 1.5 | 0.2 | 0.6 | 0.6 | 0.7 |
| Cd content in liver | 0.6 | 0.6 | 1.0 | -1.0 | -0.7 | -0.8 | -0.9 | -0.8 | -0.3 | -0.7 | -0.8 | -0.8 | -0.9 |
| Glucose | 0.5 | 0.7 | 1.1 | -0.1 | 1.0 | 1.0 | 0.7 | 1.0 | -0.6 | 1.0 | 0.9 | 0.8 | 0.8 |
| Heart weight | 0.5 | 0.8 | 1.5 | 1.2 | 0.6 | 0.8 | 1.2 | 1.0 | 0.1 | 0.7 | 0.8 | 0.9 | 0.9 |
| Left kidney weight | 0.5 | 1.4 | 3.6 | 1.8 | 0.7 | 0.9 | 1.1 | 1.2 | 1.9 | 0.8 | 1.0 | 0.7 | 1.2 |
| Intraocular pressure | 0.5 | 0.6 | 2.7 | -0.1 | 0.8 | 0.8 | 0.5 | 0.5 | -1.6 | 0.8 | 0.7 | 0.8 | 0.6 |
| Soleus weight | 0.5 | 1.6 | 2.1 | -0.3 | -1.4 | -1.4 | -1.3 | -1.3 | 1.3 | -1.4 | -1.3 | -1.4 | -1.3 |
| Times rat made contact with spout | 0.5 | 0.6 | 0.8 | -0.5 | -0.8 | -0.8 | -0.8 | -0.9 | 0.4 | -0.8 | -0.8 | -0.8 | -0.8 |
| Light reinforcement 1 | 0.5 | 0.9 | 4.5 | -2.1 | 0.3 | -0.2 | -1.1 | -0.4 | -1.6 | 0.1 | -0.3 | -0.5 | -0.6 |
| Reaction time premature initiation rate | 0.5 | 0.7 | 3.1 | 1.7 | -0.0 | 0.2 | 0.7 | 0.5 | 1.8 | 0.1 | 0.3 | 0.3 | 0.6 |
| Conditioned reinforcement - actives | 0.5 | 0.4 | 1.0 | 0.5 | 0.6 | 0.7 | 0.8 | 0.7 | -0.4 | 0.6 | 0.6 | 1.0 | 0.7 |
| Intermittent access day 15 total infusions | 0.5 | 0.6 | 1.0 | 1.0 | 0.6 | 0.7 | 1.0 | 0.8 | 0.3 | 0.6 | 0.7 | 0.9 | 0.8 |
| Short access day 10 total infusions | 0.5 | 0.6 | 1.6 | 1.3 | 0.3 | 0.5 | 1.0 | 0.7 | 1.1 | 0.4 | 0.5 | 0.5 | 0.7 |
| One hour access (shock baseline) | 0.5 | 0.6 | 2.1 | 0.8 | 0.4 | 0.5 | 1.0 | 0.7 | 1.4 | 0.4 | 0.6 | 0.6 | 0.7 |
| Locomotion velocity, session 3 | 0.5 | 0.6 | 1.0 | 0.9 | 0.6 | 0.7 | 1.0 | 0.9 | 0.1 | 0.6 | 0.7 | 0.7 | 0.8 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 2.2 | 1.1 | -0.8 | -0.6 | 0.0 | -0.4 | 1.5 | -0.8 | -0.5 | -0.4 | -0.3 |
| Incentive salience index mean | 0.5 | 0.5 | 1.1 | 0.7 | -0.9 | -0.8 | -0.3 | -0.7 | 1.1 | -0.9 | -0.7 | -0.6 | -0.6 |
| Bone: maximum diameter | 0.5 | 1.0 | 3.9 | 2.0 | -0.1 | 0.3 | 1.0 | 0.7 | 1.9 | 0.0 | 0.4 | 0.4 | 0.7 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 2.9 | 1.7 | -0.0 | 0.3 | 0.6 | 0.4 | 1.0 | 0.1 | 0.3 | 0.3 | 0.5 |
| Vertical activity count, locomotor time 2 | 0.5 | 0.5 | 2.2 | 0.9 | -0.8 | -0.6 | -0.1 | -0.4 | 1.5 | -0.7 | -0.6 | -0.0 | -0.4 |
| Progressive ratio | 0.5 | 0.6 | 0.8 | 0.2 | 0.9 | 0.8 | 0.7 | 0.8 | -0.9 | 0.8 | 0.8 | 0.8 | 0.7 |
| Cu content in liver | 0.5 | 0.6 | 2.2 | 1.2 | -0.8 | -0.5 | 0.2 | -0.3 | 1.5 | -0.7 | -0.5 | -0.4 | -0.2 |
| K content in liver | 0.5 | 0.5 | 0.8 | -0.8 | -0.6 | -0.7 | -0.9 | -0.8 | 0.2 | -0.6 | -0.7 | -0.7 | -0.8 |
| Delay discounting total patch changes 12 sec | 0.4 | 0.5 | 2.3 | 1.4 | -0.1 | 0.1 | 0.7 | 0.3 | 1.5 | -0.0 | 0.2 | 0.2 | 0.4 |
| Delay discounting total patch changes 18 sec | 0.4 | 0.5 | 1.7 | 1.3 | 0.4 | 0.6 | 0.9 | 0.7 | 0.5 | 0.5 | 0.6 | 0.6 | 0.8 |
| Delay discounting total patch changes 24 sec | 0.4 | 0.5 | 2.4 | 1.6 | 0.0 | 0.2 | 0.6 | 0.4 | 1.4 | 0.1 | 0.3 | 0.2 | 0.5 |
| Locomotor testing rearing | 0.4 | 0.6 | 3.6 | 1.2 | 0.0 | 0.2 | 0.6 | 0.5 | 1.9 | 0.1 | 0.3 | 0.1 | 0.5 |
| Reaction time premature initiations | 0.4 | 0.6 | 1.7 | 1.3 | 0.4 | 0.6 | 0.9 | 0.7 | 1.0 | 0.5 | 0.6 | 0.7 | 0.8 |
| Lifetime Intake | 0.4 | 0.5 | 0.9 | 0.9 | 0.4 | 0.5 | 1.0 | 0.7 | 0.8 | 0.4 | 0.6 | 0.7 | 0.7 |
| Pavlov. Cond. response bias | 0.4 | 0.5 | 1.1 | 1.1 | 0.4 | 0.5 | 0.9 | 0.7 | 0.8 | 0.4 | 0.6 | 0.6 | 0.7 |
| Bone: endosteal perimeter | 0.4 | 0.8 | 3.4 | 1.9 | -0.3 | 0.0 | 0.8 | 0.4 | 1.8 | -0.2 | 0.1 | 0.2 | 0.4 |
| Bone: trabecular number | 0.4 | 0.6 | 3.2 | -1.5 | 0.1 | -0.1 | -0.5 | -0.3 | -1.8 | 0.1 | -0.2 | -0.1 | -0.4 |
| Breakpoint value in progressive ratio session | 0.4 | 0.4 | 0.6 | -0.5 | 0.8 | 0.6 | 0.4 | 0.6 | -0.6 | 0.8 | 0.6 | 0.7 | 0.5 |
| Time in closed arm after self-admin | 0.4 | 0.4 | 0.6 | -0.7 | -0.4 | -0.5 | -0.6 | -0.7 | -0.8 | -0.5 | -0.6 | -0.6 | -0.6 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 0.6 | 0.2 | 0.7 | 0.6 | 0.6 | 0.7 | 0.4 | 0.7 | 0.7 | 0.8 | 0.6 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.4 | 0.8 | 0.6 | 0.5 | 0.6 | 0.9 | 0.6 | -0.6 | 0.5 | 0.7 | 0.9 | 0.6 |
| Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 2.3 | 1.0 | -0.5 | -0.3 | 0.3 | -0.2 | 1.5 | -0.4 | -0.3 | -0.3 | -0.1 |
| Bouts of movement, locomotor time 1 | 0.4 | 0.4 | 0.7 | 0.4 | -0.8 | -0.7 | -0.5 | -0.6 | -0.2 | -0.8 | -0.8 | -0.5 | -0.6 |
| Weight adjusted by age | 0.4 | 0.5 | 1.4 | 1.2 | 0.4 | 0.5 | 0.9 | 0.7 | 0.5 | 0.4 | 0.6 | 0.6 | 0.7 |
| Seeking ratio, punishment vs. effort | 0.4 | 0.5 | 3.5 | 0.9 | -0.5 | -0.3 | 0.1 | -0.2 | 1.9 | -0.5 | -0.2 | -0.3 | -0.0 |
| Epididymis fat weight | 0.3 | 0.6 | 0.9 | -0.7 | -0.7 | -0.8 | -0.9 | -0.8 | 0.7 | -0.7 | -0.8 | -1.0 | -0.8 |
| Length without tail | 0.3 | 0.5 | 0.8 | -0.7 | -0.7 | -0.7 | -0.9 | -0.7 | 0.5 | -0.7 | -0.7 | -0.9 | -0.7 |
| Water consumed over 24 hours | 0.3 | 0.4 | 0.8 | -0.9 | -0.4 | -0.5 | -0.8 | -0.7 | -0.7 | -0.4 | -0.5 | -0.6 | -0.6 |
| Indifference point function ln k | 0.3 | 0.4 | 0.7 | 0.1 | 0.7 | 0.7 | 0.6 | 0.6 | -0.6 | 0.7 | 0.7 | 0.9 | 0.7 |
| Indifference point function log k | 0.3 | 0.4 | 0.7 | 0.1 | 0.7 | 0.7 | 0.6 | 0.6 | -0.6 | 0.7 | 0.7 | 0.9 | 0.7 |
| Reaction time omissions | 0.3 | 0.4 | 1.0 | -1.0 | -0.4 | -0.6 | -0.8 | -0.5 | -0.0 | -0.4 | -0.5 | -0.6 | -0.7 |
| Intermittent access intake escalation 2 | 0.3 | 0.3 | 0.5 | -0.5 | 0.7 | 0.6 | 0.2 | 0.5 | -0.3 | 0.6 | 0.5 | 0.5 | 0.5 |
| Intermitt. access day 15 inactive lever presses | 0.3 | 0.3 | 0.7 | 0.8 | 0.3 | 0.4 | 0.6 | 0.4 | -0.4 | 0.4 | 0.4 | 0.9 | 0.4 |
| Intermittent access terminal intake (last 3 days) | 0.3 | 0.4 | 0.7 | 0.8 | 0.3 | 0.5 | 0.9 | 0.6 | 0.6 | 0.4 | 0.5 | 0.8 | 0.6 |
| Intermittent access total locomotion | 0.3 | 0.4 | 0.6 | 0.8 | 0.5 | 0.6 | 0.8 | 0.7 | 0.0 | 0.5 | 0.6 | 0.7 | 0.6 |
| Intermittent access standard deviation | 0.3 | 0.3 | 0.6 | -0.5 | 0.6 | 0.5 | 0.2 | 0.4 | -0.2 | 0.6 | 0.5 | 0.8 | 0.4 |
| Locomotion velocity, session 7 | 0.3 | 0.4 | 0.6 | -0.4 | 0.8 | 0.7 | 0.3 | 0.6 | -0.5 | 0.8 | 0.6 | 0.5 | 0.5 |
| Pavlov. Cond. change in total contacts | 0.3 | 0.3 | 1.4 | 1.2 | -0.5 | -0.2 | 0.4 | -0.0 | 1.0 | -0.4 | -0.2 | -0.2 | 0.0 |
| Bone: endosteal estimation | 0.3 | 0.7 | 3.6 | 1.5 | -0.8 | -0.4 | 0.4 | 0.0 | 1.9 | -0.7 | -0.4 | -0.2 | -0.0 |
| Bone: marrow area | 0.3 | 0.7 | 3.3 | 1.3 | -0.9 | -0.6 | 0.2 | -0.2 | 1.8 | -0.8 | -0.5 | -0.4 | -0.2 |
| Bone: maximum moment | 0.3 | 0.6 | 0.9 | 0.1 | -1.0 | -0.8 | -0.6 | -0.7 | 0.7 | -0.9 | -0.8 | -0.9 | -0.7 |
| Bone: periosteal estimation | 0.3 | 0.5 | 2.9 | 1.2 | -0.6 | -0.3 | 0.3 | 0.1 | 1.7 | -0.5 | -0.3 | -0.2 | -0.0 |
| Bone: periosteal perimeter | 0.3 | 0.5 | 2.0 | 1.4 | 0.0 | 0.2 | 0.7 | 0.6 | 1.4 | 0.1 | 0.3 | 0.3 | 0.5 |
| Ambulatory time before self-admin | 0.3 | 0.3 | 1.4 | -1.2 | -0.0 | -0.2 | -0.6 | -0.3 | -1.0 | -0.1 | -0.3 | -0.4 | -0.4 |
| Delay disc. indifference point, 2s delay | 0.3 | 0.3 | 1.3 | 0.8 | -0.6 | -0.4 | 0.2 | -0.3 | 1.2 | -0.6 | -0.4 | 0.0 | -0.3 |
| Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 0.5 | -0.6 | -0.6 | -0.6 | -0.6 | -0.7 | -0.3 | -0.6 | -0.7 | -0.5 | -0.7 |
| Run reversals in cocaine runway, females | 0.3 | 0.3 | 1.7 | 0.7 | -0.0 | 0.0 | 0.2 | 0.3 | 1.3 | 0.0 | 0.2 | -0.6 | 0.2 |
| Run reversals in cocaine runway, males | 0.3 | 0.3 | 0.5 | -0.6 | -0.5 | -0.6 | -0.7 | -0.6 | -0.1 | -0.5 | -0.7 | -0.4 | -0.7 |
| Latency to leave start box in cocaine runway, M | 0.3 | 0.3 | 2.0 | -1.1 | 0.1 | -0.1 | -0.0 | -0.2 | -1.4 | 0.0 | -0.2 | 0.2 | -0.3 |
| Body weight | 0.2 | 0.8 | 6.3 | 1.2 | -0.3 | -0.2 | 0.0 | 0.1 | 2.5 | -0.3 | -0.1 | -0.4 | 0.1 |
| Right kidney weight | 0.2 | 0.6 | 3.4 | 1.4 | 0.1 | 0.3 | 0.5 | 0.5 | 1.8 | 0.2 | 0.4 | 0.1 | 0.5 |
| Parametrial fat weight | 0.2 | 0.4 | 2.0 | -1.4 | 0.5 | 0.3 | -0.3 | 0.1 | -1.0 | 0.4 | 0.2 | 0.0 | 0.0 |
| Tibia length | 0.2 | 0.5 | 1.6 | 1.3 | 0.3 | 0.6 | 1.0 | 0.7 | 0.4 | 0.4 | 0.6 | 0.7 | 0.7 |
| Reaction time number correct | 0.2 | 0.3 | 0.4 | -0.0 | 0.6 | 0.6 | 0.5 | 0.5 | -0.6 | 0.6 | 0.5 | 0.7 | 0.5 |
| Reaction time trials correct on left | 0.2 | 0.3 | 0.4 | -0.0 | 0.6 | 0.6 | 0.5 | 0.5 | -0.6 | 0.6 | 0.5 | 0.7 | 0.5 |
| Reaction time trials on left | 0.2 | 0.3 | 0.5 | -0.1 | 0.7 | 0.6 | 0.5 | 0.5 | -0.7 | 0.6 | 0.5 | 0.7 | 0.5 |
| Reaction time trials completed | 0.2 | 0.3 | 0.5 | -0.1 | 0.7 | 0.6 | 0.5 | 0.5 | -0.7 | 0.6 | 0.5 | 0.7 | 0.5 |
| Social response proportion | 0.2 | 0.2 | 0.5 | -0.3 | -0.3 | -0.4 | -0.7 | -0.7 | 0.1 | -0.4 | -0.4 | -0.6 | -0.5 |
| Intermitt. access escalation Index | 0.2 | 0.2 | 0.3 | 0.3 | -0.4 | -0.4 | -0.4 | -0.4 | 0.6 | -0.4 | -0.3 | -0.3 | -0.3 |
| Intermittent access day 1 total infusions | 0.2 | 0.3 | 1.2 | 1.0 | -0.3 | -0.1 | 0.5 | 0.2 | 1.1 | -0.2 | -0.0 | -0.1 | 0.2 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 0.4 | 0.1 | -0.6 | -0.5 | -0.3 | -0.5 | -0.2 | -0.6 | -0.5 | -0.5 | -0.5 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 1.3 | 0.8 | -0.4 | -0.2 | 0.3 | 0.0 | 1.2 | -0.3 | -0.1 | -0.2 | 0.0 |
| Short access day 10 total locomotion | 0.2 | 0.2 | 0.5 | 0.0 | 0.6 | 0.5 | 0.3 | 0.4 | -0.2 | 0.6 | 0.6 | 0.7 | 0.5 |
| Short access total locomotion | 0.2 | 0.2 | 0.2 | -0.0 | 0.4 | 0.4 | 0.4 | 0.4 | -0.5 | 0.4 | 0.4 | 0.4 | 0.4 |
| Compulsive drug intake | 0.2 | 0.2 | 1.6 | -0.4 | 0.2 | 0.1 | -0.4 | -0.1 | -1.3 | 0.1 | 0.0 | -0.1 | -0.1 |
| Stereotopy head waving duration, day 3 | 0.2 | 0.3 | 0.4 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | -0.2 | 0.6 | 0.6 | 0.5 | 0.6 |
| Locomotion distance, session 7 | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | -0.5 | -0.6 | -0.4 | 0.3 | -0.4 | -0.5 | -0.6 | -0.5 |
| Condit. Reinf. inactive responses | 0.2 | 0.2 | 0.4 | -0.6 | -0.2 | -0.4 | -0.6 | -0.4 | -0.3 | -0.3 | -0.4 | -0.5 | -0.5 |
| Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.3 | 0.5 | 0.3 | 0.4 | 0.5 | 0.5 | 0.6 | 0.3 | 0.4 | 0.4 | 0.5 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.7 | 0.9 | 0.0 | 0.2 | 0.6 | 0.4 | 0.6 | 0.1 | 0.2 | 0.2 | 0.4 |
| Bone: cortical area | 0.2 | 0.2 | 1.6 | 0.6 | -0.3 | -0.2 | 0.0 | 0.0 | 1.3 | -0.3 | -0.2 | -0.2 | -0.0 |
| Distance traveled before self-admin | 0.2 | 0.2 | 1.0 | -1.0 | 0.2 | -0.0 | -0.6 | -0.1 | -0.8 | 0.1 | -0.1 | -0.2 | -0.2 |
| Time in open arm after self-admin | 0.2 | 0.3 | 0.5 | 0.2 | -0.6 | -0.6 | -0.4 | -0.5 | 0.7 | -0.6 | -0.5 | -0.2 | -0.5 |
| Delay disc. indifference point, 0s delay | 0.2 | 0.3 | 0.7 | 0.8 | 0.3 | 0.4 | 0.6 | 0.5 | 0.5 | 0.4 | 0.5 | 0.2 | 0.5 |
| Time >=10cm from walls, locomotor time 1 | 0.2 | 0.2 | 1.1 | 1.0 | 0.0 | 0.2 | 0.4 | 0.2 | 0.5 | 0.1 | 0.3 | 0.3 | 0.3 |
| Total resting periods, locomotor time 1 | 0.2 | 0.3 | 0.4 | -0.1 | -0.6 | -0.5 | -0.5 | -0.6 | -0.6 | -0.6 | -0.6 | -0.2 | -0.6 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.4 | 0.4 | -0.6 | -0.5 | -0.3 | -0.3 | 0.3 | -0.6 | -0.6 | -0.3 | -0.4 |
| Na content in liver | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.4 | 0.5 | 0.4 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 |
| Tibialis anterior weight | 0.1 | 0.4 | 2.0 | 0.4 | -0.6 | -0.6 | -0.3 | -0.3 | 1.4 | -0.6 | -0.5 | -0.5 | -0.4 |
| Indifference point AUC | 0.1 | 0.1 | 0.7 | 0.7 | -0.3 | -0.2 | 0.2 | -0.0 | 0.8 | -0.2 | -0.1 | -0.3 | 0.0 |
| Reaction time mean minus median | 0.1 | 0.2 | 0.7 | 0.7 | -0.1 | 0.0 | 0.3 | 0.3 | 0.9 | -0.0 | 0.1 | 0.1 | 0.2 |
| Reaction time mean minus median AUC | 0.1 | 0.2 | 0.6 | 0.7 | 0.1 | 0.2 | 0.4 | 0.4 | 0.8 | 0.2 | 0.2 | 0.3 | 0.4 |
| Reaction time trials AUC | 0.1 | 0.2 | 0.3 | 0.0 | 0.5 | 0.5 | 0.4 | 0.4 | -0.4 | 0.5 | 0.4 | 0.5 | 0.4 |
| Cocaine response after cond. not corrected | 0.1 | 0.2 | 0.9 | -0.9 | 0.2 | 0.0 | -0.4 | -0.1 | -0.6 | 0.1 | -0.0 | -0.0 | -0.2 |
| Intermittent access total infusions | 0.1 | 0.2 | 0.7 | 0.6 | 0.0 | 0.1 | 0.5 | 0.3 | 0.8 | 0.1 | 0.2 | 0.4 | 0.3 |
| Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.8 | 0.6 | -0.1 | 0.0 | 0.4 | 0.2 | 0.9 | -0.1 | 0.1 | -0.0 | 0.2 |
| Progressive ratio test 2 active lever presses | 0.1 | 0.1 | 0.4 | 0.3 | -0.5 | -0.4 | 0.1 | -0.2 | 0.6 | -0.4 | -0.3 | -0.3 | -0.2 |
| Progressive ratio test 2 breakpoint | 0.1 | 0.2 | 0.6 | 0.4 | -0.5 | -0.3 | 0.2 | -0.2 | 0.8 | -0.4 | -0.3 | -0.3 | -0.2 |
| Total locomotion distance, NPP test | 0.1 | 0.1 | 0.5 | -0.3 | 0.2 | 0.1 | -0.3 | 0.0 | 0.7 | 0.2 | 0.1 | -0.1 | 0.0 |
| Locomotion velocity, NPP test | 0.1 | 0.1 | 0.4 | -0.7 | 0.2 | 0.0 | -0.5 | -0.1 | 0.4 | 0.2 | 0.1 | -0.2 | -0.1 |
| Pavlov. Cond. lever latency | 0.1 | 0.2 | 0.8 | -0.9 | 0.1 | -0.0 | -0.5 | -0.2 | -0.6 | 0.1 | -0.1 | -0.1 | -0.2 |
| Bone: apparent density | 0.1 | 0.2 | 1.2 | -0.6 | -0.1 | -0.2 | -0.2 | -0.2 | -1.1 | -0.1 | -0.3 | -0.2 | -0.3 |
| Bone surface | 0.1 | 0.1 | 1.0 | 1.0 | -0.2 | 0.0 | 0.4 | 0.2 | 0.4 | -0.1 | -0.0 | 0.1 | 0.2 |
| Bone volume | 0.1 | 0.1 | 0.5 | 0.7 | -0.3 | -0.2 | 0.1 | -0.0 | 0.4 | -0.3 | -0.2 | -0.2 | -0.0 |
| Bone: post-yield work | 0.1 | 0.1 | 0.4 | 0.3 | 0.2 | 0.2 | 0.3 | 0.4 | 0.6 | 0.2 | 0.2 | 0.2 | 0.3 |
| Extinction: sum of active levers before priming | 0.1 | 0.1 | 1.0 | -1.0 | -0.1 | -0.2 | 0.0 | -0.2 | 0.2 | -0.1 | -0.2 | 0.1 | -0.2 |
| Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.4 | 0.2 | 0.4 | 0.2 | 0.3 | 0.3 | 0.5 | 0.4 |
| Delta time to tail flick, test, before/after SA | 0.1 | 0.1 | 0.2 | -0.5 | -0.2 | -0.3 | -0.4 | -0.3 | 0.2 | -0.2 | -0.3 | -0.2 | -0.3 |
| Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.4 | 0.5 | 0.1 | 0.1 | -0.2 | 0.2 | 0.7 | 0.1 | 0.2 | -0.4 | 0.2 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.3 | -0.4 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 | -0.4 | -0.3 |
| Mg content in liver | 0.1 | 0.1 | 0.1 | 0.0 | 0.3 | 0.3 | 0.2 | 0.2 | 0.0 | 0.3 | 0.3 | 0.3 | 0.2 |
| Rb content in liver | 0.1 | 0.1 | 0.7 | 0.8 | -0.3 | -0.1 | 0.3 | -0.1 | 0.5 | -0.3 | -0.1 | 0.0 | 0.0 |
| Extensor digitorum longus weight | 0.0 | 0.1 | 0.4 | -0.6 | -0.1 | -0.3 | -0.5 | -0.2 | 0.3 | -0.2 | -0.3 | -0.4 | -0.3 |
| Progressive ratio test 1 active lever presses | 0.0 | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | 0.2 | 0.1 | -0.1 | 0.0 | 0.0 | 0.1 | 0.0 |
| Progressive ratio test 1 breakpoint | 0.0 | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | 0.1 | -0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Progressive ratio test 1 inactive lever presses | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | -0.1 | -0.0 | -0.1 | 0.3 | -0.2 | -0.2 | -0.3 | -0.1 |
| Progressive ratio test 2 inactive lever presses | 0.0 | 0.0 | 0.1 | 0.2 | 0.0 | 0.1 | 0.3 | 0.1 | 0.2 | 0.1 | 0.1 | 0.4 | 0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.1 | 0.1 | -0.1 | -0.3 | -0.3 | -0.2 | -0.3 | -0.2 | -0.3 | -0.3 | -0.2 | -0.3 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.1 | 0.3 | -0.2 | -0.1 | 0.2 | -0.0 | -0.4 | -0.2 | -0.1 | 0.1 | -0.1 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.2 | 0.4 | -0.3 | -0.2 | 0.2 | -0.1 | -0.2 | -0.3 | -0.2 | 0.0 | -0.1 |
| Bone: cortical thickness | 0.0 | 0.1 | 0.4 | -0.6 | 0.3 | 0.2 | -0.2 | 0.1 | -0.2 | 0.3 | 0.2 | 0.0 | 0.1 |
| Bone: cortical thickness | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.0 | 0.1 | 0.1 | 0.2 | -0.0 | -0.0 | 0.1 | 0.0 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.1 | -0.1 | 0.3 | 0.2 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | 0.2 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.