Hub : Genes

Thop1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000019924	0.05	0.04	2.5e-04	0.03	0.03	0.01	0.02	6.0e-04	8.4e-04	1.6e-02	3.1e-03
2	IL	mRNA stability	ENSRNOG00000019924	0.2	0.14	1.4e-03	0.06	0.02	0.03	0.03	1.6e-02	1.2e-01	5.4e-02	7.1e-02
3	PL	mRNA stability	ENSRNOG00000019924	0.07	0.05	1.7e-05	0.07	0.06	0.07	0.07	3.1e-06	1.2e-05	5.0e-06	5.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	6.6	21.4	23.1	-4.6	4.5	4.8
BMI without tail	2.7	5.6	7.5	-2.4	1.9	2.7
Body weight	1.2	5.0	5.4	-2.3	2.1	2.2
Epididymis fat weight	0.1	0.2	0.6	0.4	-0.8	-0.1
Glucose	1.4	2.1	2.5	-1.4	1.4	1.6
Heart weight	0.2	0.3	0.7	0.4	-0.8	-0.2
Left kidney weight	0.1	0.4	0.6	0.8	-0.0	-0.7
Right kidney weight	1.5	4.4	4.8	2.2	-1.9	-2.2
Tail length	2.8	8.4	10.9	2.7	-3.3	-2.7
Length with tail	2.0	7.3	8.4	2.6	-2.6	-2.9
Length without tail	0.2	0.5	1.1	0.7	0.0	-1.0
Liver weight, left	2.9	4.7	5.7	-2.1	2.0	2.4
Liver weight, right	1.7	2.8	3.1	-1.5	1.8	1.7
Parametrial fat weight	0.4	0.7	1.0	0.7	-1.0	-0.7
Retroperitoneal fat weight	0.5	1.6	2.5	-1.6	1.0	1.2
Intraocular pressure	0.2	0.3	0.5	-0.4	-0.5	0.7
Extensor digitorum longus weight	5.0	20.0	22.8	-4.6	3.9	4.8
Soleus weight	8.7	25.3	26.7	-4.9	5.2	5.0
Tibialis anterior weight	1.0	3.6	4.1	-1.6	2.0	2.0
Tibia length	0.8	2.3	2.8	1.4	-1.7	-1.5
Number of licking bursts	0.3	0.4	0.6	-0.8	-0.2	0.7
Food consumed during 24 hour testing period	0.6	0.7	1.1	-0.8	0.7	1.0
Times rat made contact with spout	0.4	0.5	0.7	-0.7	0.3	0.9
Mean time between licks in bursts	3.7	5.1	6.5	2.0	-2.6	-2.2
Mean num. licks in bursts	0.0	0.0	0.1	0.2	0.3	-0.1
Std. dev. time between licks in bursts	1.2	1.4	1.8	1.3	-0.8	-1.3
Water consumed over 24 hours	0.3	0.4	1.0	-0.3	1.0	0.3
Indifference point 0 sec	0.1	0.2	0.3	-0.5	0.5	0.2
Indifference point AUC	0.9	1.1	1.4	1.1	-1.2	-0.8
Indifference point function ln k	0.2	0.3	0.5	-0.7	0.6	0.5
Indifference point function log k	0.2	0.3	0.5	-0.7	0.6	0.5
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	-0.5	0.4	0.2
Delay discounting total patch changes 12 sec	0.5	0.7	1.1	-0.9	0.4	1.1
Delay discounting total patch changes 18 sec	1.0	1.3	1.5	1.1	-1.2	-1.1
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	0.4	-0.3	-0.2
Delay discounting total patch changes 6 sec	0.2	0.3	0.5	0.3	-0.6	-0.7
Delay discounting time to switch 0 sec	1.1	1.7	3.4	-1.1	1.8	0.8
Delay discounting water rate 0 sec	0.2	0.3	0.4	-0.4	-0.6	0.5
Delay discounting water rate 12 sec	1.5	2.3	3.3	-1.7	0.8	1.8
Delay discounting water rate 18 sec	0.7	0.9	1.1	-0.8	-1.0	1.0
Delay discounting water rate 24 sec	1.5	2.1	3.5	-1.9	-0.1	1.7
Delay discounting water rate 6 sec	0.3	0.4	1.2	-0.1	-1.1	0.1
Locomotor activity	4.2	6.7	8.4	2.7	-2.1	-2.9
Locomotor testing distance	2.4	4.1	4.9	2.1	-1.7	-2.2
Locomotor testing rearing	0.0	0.0	0.1	0.1	-0.3	-0.1
Light reinforcement 1	5.7	10.5	11.8	3.2	-3.1	-3.4
Light reinforcement 2	2.0	2.7	3.6	1.5	-1.5	-1.9
Reaction time number correct	0.9	1.4	1.9	-1.4	0.5	1.4
Reaction time mean minus median	0.8	1.1	1.5	1.2	-1.1	-0.8
Reaction time mean minus median AUC	0.3	0.4	0.9	0.9	0.2	-0.5
Reaction time num false alarms	0.1	0.1	0.3	-0.3	0.0	0.5
Reaction time num false alarms AUC	0.2	0.3	0.6	-0.6	0.1	0.8
Reaction time trials correct on left	0.9	1.4	1.9	-1.4	0.5	1.4
Reaction time trials on left	0.9	1.3	1.8	-1.3	0.5	1.4
Reaction time mean	0.1	0.1	0.3	0.5	0.2	-0.2
Reaction time mean AUC	0.1	0.1	0.2	0.4	0.3	-0.2
Median of all reaction times	0.2	0.2	0.6	-0.0	0.7	0.2
Reaction time omissions	0.4	0.5	0.5	0.7	-0.6	-0.7
Reaction time false alarm rate	0.0	0.0	0.0	0.1	0.1	0.1
Reaction time premature initiation rate	0.8	1.1	2.0	0.6	-1.4	-0.9
Reaction time premature initiations	0.4	0.5	1.5	-0.1	-1.2	-0.3
Std. dev. reaction times	0.4	0.5	1.0	1.0	-0.5	-0.6
Reaction time trials completed	0.9	1.3	1.8	-1.3	0.5	1.4
Reaction time trials AUC	1.0	1.4	2.0	-1.4	0.4	1.4
Social response proportion	0.7	0.8	1.1	1.1	-0.6	-1.0
Social responses	8.3	10.7	13.3	3.6	-2.8	-3.3
Social time	0.8	1.0	1.2	-1.1	0.9	1.0
Conditioned locomotion	2.2	2.7	3.9	-2.0	1.1	1.7
Cocaine response after cond. corrected	6.4	7.2	8.8	-3.0	2.0	2.9
Cocaine response after cond. not corrected	6.9	7.7	9.5	-3.1	2.1	3.0
Cocaine response before conditioning	0.6	0.7	0.9	1.0	-0.6	-1.0
Saline control response	0.1	0.1	0.2	-0.4	0.2	0.4
Condit. Reinf. active minus inactive responses	1.8	2.2	3.8	1.2	-1.9	-1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.4	-0.7	0.4
Condit. Reinf. active responses	2.2	3.0	3.5	1.7	-1.9	-1.7
Condit. Reinf. inactive responses	1.6	2.0	2.4	1.5	-1.1	-1.6
Condit. Reinf. lever presses	2.0	2.7	3.9	1.5	-2.0	-1.4
Condit. Reinf. lever reinforcers received	1.5	2.1	2.9	1.3	-1.7	-1.3
Pavlov. Cond. lever latency	1.1	1.5	1.8	-1.2	1.0	1.4
Pavlov. Cond. magazine entry latency	0.7	0.8	1.0	1.0	-0.7	-0.9
Pavlov. Cond. change in total contacts	0.9	1.2	1.3	1.1	-1.1	-1.1
Pavlov. Cond. index score	1.1	1.4	1.5	1.2	-1.1	-1.2
Pavlov. Cond. latency score	1.1	1.4	1.7	1.2	-1.0	-1.3
Pavlov. Cond. lever contacts	0.8	1.1	1.2	1.0	-1.1	-1.1
Pavlov. Cond. magazine entry number	1.1	1.3	1.7	-1.3	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.4	-1.2	0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.7	1.3	-1.1	-1.3
Pavlov. Cond. response bias	1.8	2.5	2.9	1.5	-1.7	-1.5
Conditioned reinforcement - actives	2.5	2.5	2.7	1.6	-1.5	-1.5
Conditioned reinforcement - inactives	1.0	1.2	2.1	-1.5	0.6	1.0
Conditioned locomotion	7.5	9.0	10.4	2.9	-3.2	-2.8
Intermittent access intake day 1-15 change	5.9	5.9	7.8	2.2	-2.8	-2.3
Intermittent access intake escalation	4.8	4.7	8.3	1.6	-2.9	-1.8
Intermittent access intake escalation 2	6.2	6.1	10.0	2.0	-3.2	-2.1
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.6	0.2	-0.7	0.1
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.8	0.2	-0.9	-0.5
Intermitt. access escalation Index	0.2	0.1	0.3	0.3	0.6	-0.1
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.4	0.3	0.2
Intermittent access day 15 total infusions	1.4	1.6	2.9	0.8	-1.7	-1.1
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.6	0.9	-1.3	-0.9
Intermittent access total infusions	0.2	0.2	0.5	0.0	-0.7	-0.3
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.1	-0.7	-0.5
Intermittent access day 15 total locomotion	2.9	3.0	4.5	1.4	-2.1	-1.6
Intermittent access total locomotion	0.9	1.1	1.7	0.8	-1.3	-1.0
Intermittent access standard deviation	2.6	2.8	4.6	1.4	-2.1	-1.4
Cocaine induced anxiety	1.3	1.5	2.2	1.5	-0.6	-1.4
Post-drug Anxiety	1.2	1.3	2.2	1.5	-0.2	-1.3
Baseline Anxiety	0.0	0.0	0.1	-0.2	-0.3	0.1
Lifetime Intake	0.1	0.1	0.2	0.0	-0.4	-0.2
Incentive Sensitization - Responses	0.3	0.3	0.8	0.4	-0.9	0.1
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	0.5	-0.9	0.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.7	0.3	0.4
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.7	0.4	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	-0.2
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.1	-0.7	0.0
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.5	-0.7	-0.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.2	-0.3	-0.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	0.1	-0.3
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	-0.2	-0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.2	-0.4	0.2
Short access day 1 total infusions	0.4	0.4	0.8	0.7	-0.1	-0.9
Short access day 10 total infusions	0.0	0.0	0.1	-0.1	-0.2	0.0
Short access total infusions	0.0	0.0	0.1	0.2	-0.0	-0.2
Short access day 1 locomotion	1.1	1.1	2.1	0.8	-0.8	-1.4
Short access day 10 total locomotion	3.7	4.1	6.0	1.6	-2.4	-1.9
Short access total locomotion	1.1	1.1	1.3	0.9	-1.1	-1.1
Compulsive drug intake	0.8	0.8	1.3	-0.7	1.1	0.7
One hour access (0.3 mA shock)	0.3	0.3	0.6	-0.8	0.4	0.5
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	-0.4	0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.4	-0.2	-0.4
Context. condit. distance diff. score	0.3	0.4	0.4	-0.6	0.6	0.6
Locomotion velocity, session 1	1.1	1.2	1.7	1.3	-0.4	-1.3
Locomotion distance, session 1	0.5	0.7	1.1	0.9	0.2	-1.1
Locomotion velocity, session 2	4.5	5.2	7.0	2.6	-1.5	-2.5
Locomotion distance, session 2	2.1	3.1	4.2	2.0	-0.9	-2.0
Locomotion velocity, session 3	5.7	6.6	7.2	2.6	-2.7	-2.5
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.0	0.2
Stereotopy head waving bouts, day 3	4.9	5.9	6.4	2.5	-2.2	-2.5
Stereotopy head waving duration, day 3	5.6	6.8	7.1	2.6	-2.5	-2.7
Locomotion velocity, session 7	0.9	1.0	1.2	1.0	-0.8	-1.1
Locomotion distance, session 7	0.2	0.2	0.4	-0.5	0.1	0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	0.6	0.3	-0.5
Stereotopy head waving duration, day 7	0.5	0.7	1.0	1.0	-0.1	-1.0
Locomotion velocity, session 8	1.2	1.4	2.1	1.4	-0.3	-1.4
Locomotion distance, session 8	0.1	0.2	0.3	0.5	-0.2	-0.5
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.6	0.5
Degree of sensitization stereotypy	1.3	1.4	2.7	-0.9	1.6	0.9
Condit. Reinf. active minus inactive responses	3.9	4.3	4.6	2.1	-2.1	-2.0
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.7	1.2	-1.6	-1.1
Condit. Reinf. active responses	3.9	4.7	5.6	2.4	-1.9	-2.2
Condit. Reinf. inactive responses	1.2	1.4	2.0	1.4	-0.6	-1.4
Incentive salience index mean	2.4	2.9	3.7	1.9	-1.4	-1.7
Condit. Reinf. lever presses	0.4	0.5	0.9	0.9	0.4	-0.7
Time in familiar zone, hab. session 1	1.8	1.7	2.4	1.2	-1.6	-1.1
Time in novel zone, hab. session 1	0.6	0.6	1.4	-0.5	1.2	0.4
Total zone transitions, hab. session 1	1.3	1.8	2.5	1.6	-0.7	-1.6
Total locomotion distance, hab. session 1	2.0	2.8	4.0	2.0	-0.6	-2.0
Locomotion velocity, hab. session 1	2.2	3.1	4.2	2.1	-1.0	-2.1
Time in familiar zone, hab. session 2	4.9	5.2	7.6	2.1	-2.8	-1.9
Time in novel zone, hab. session 2	3.4	3.5	5.7	-1.6	2.4	1.4
Total zone transitions, hab. session 2	0.2	0.3	0.7	0.2	0.8	-0.4
Total locomotion distance, hab. session 2	1.2	1.6	2.3	1.4	-0.7	-1.5
Locomotion velocity, hab. session 2	1.3	1.8	2.7	1.5	-0.6	-1.6
Novel to familiar place preference ratio	2.8	3.0	5.5	-1.3	2.3	1.3
Novelty place preference	1.6	1.7	3.4	-0.9	1.9	0.9
Time in novel zone, NPP test	1.9	2.0	3.9	-1.0	2.0	1.1
Total zone transitions, NPP test	0.0	0.1	0.1	0.2	0.3	-0.2
Total locomotion distance, NPP test	0.1	0.2	0.2	0.3	0.5	-0.3
Locomotion velocity, NPP test	0.2	0.3	0.4	0.6	0.2	-0.6
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.5	-0.4	0.4
Pavlov. Cond. magazine entry latency	2.5	3.2	4.1	1.7	-2.0	-1.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	-0.2	-0.3
Pavlov. Cond. index score	0.5	0.6	0.9	0.9	-0.5	-0.9
Pavlov. Cond. latency score	0.6	0.8	1.2	1.1	-0.4	-1.0
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.8	0.2	-0.7
Pavlov. Cond. magazine entry number	0.6	0.7	0.8	-0.8	0.9	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	-0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.4	1.2	-0.8	-1.1
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	-1.1	-1.1
Bone: apparent density	0.5	0.9	1.3	1.2	0.6	-1.0
Bone surface	1.6	2.8	4.7	2.2	0.3	-1.9
Bone volume	1.7	2.9	4.7	2.2	0.3	-2.0
Bone: connectivity density	0.3	0.4	0.9	0.5	1.0	-0.3
Bone: cortical apparent density	0.8	1.1	1.3	-1.1	1.0	1.0
Bone: cortical area	0.3	0.4	1.3	-0.1	1.1	0.1
Bone: cortical porosity	0.8	0.9	1.3	1.0	-0.6	-1.1
Bone: cortical porosity	0.3	0.3	0.6	0.6	0.1	-0.8
Bone: cortical thickness	0.8	1.3	2.1	-1.0	1.5	0.9
Bone: cortical thickness	0.1	0.1	0.1	-0.3	-0.3	0.3
Bone: cortical tissue density	0.6	0.8	0.9	-1.0	0.8	0.8
Bone: elastic displacement	0.3	0.4	0.4	0.7	-0.5	-0.6
Bone: elastic work	0.1	0.1	0.4	-0.1	0.6	0.1
Bone: endosteal estimation	0.1	0.3	0.6	-0.2	0.8	0.4
Bone: endosteal perimeter	0.5	1.0	1.6	1.3	-0.4	-1.1
Bone: final force	0.7	1.2	2.6	-0.7	1.6	0.7
Bone: final moment	0.6	0.9	2.1	-0.6	1.4	0.6
Bone: marrow area	0.1	0.3	0.7	-0.2	0.8	0.4
Bone: maximum diameter	1.1	2.1	2.9	1.7	-0.8	-1.7
Bone: maximum force	0.8	1.4	2.6	-0.9	1.6	0.8
Bone: maximum moment	0.6	1.1	2.1	-0.8	1.5	0.7
Bone: minimum diameter	0.1	0.1	0.2	0.4	0.3	-0.4
Bone: periosteal estimation	0.2	0.4	1.1	-0.0	1.1	0.1
Bone: periosteal perimeter	0.4	0.6	0.9	1.0	0.0	-0.9
Bone: post-yield work	0.6	0.8	0.9	-0.9	0.8	0.9
Bone: stiffness	2.4	3.8	5.5	-1.8	2.3	1.7
Bone: tissue strength	1.5	1.4	1.8	-1.1	1.4	1.1
Bone: trabecular number	1.3	2.1	3.1	1.8	-0.6	-1.7
Bone: trabecular spacing	1.6	2.0	3.1	-1.7	0.1	1.8
Bone: trabecular thickness	1.5	1.8	2.6	1.6	0.7	-1.5
Bone: trabecular tissue density	2.4	3.4	4.9	-2.2	1.4	1.9
Breakpoint value in progressive ratio session	4.3	4.8	6.9	2.0	-2.6	-1.9
Distance traveled before self-admin	0.2	0.2	0.2	-0.2	0.5	0.5
Distance traveled after self-admin	0.9	1.0	1.2	1.1	-1.0	-0.9
Delta time in closed arm before/after self-admin	1.7	1.7	2.9	-1.4	0.3	1.7
Delta time in open arm before/after self-admin	1.0	1.0	1.3	-1.0	1.2	0.7
Diff in mean of infusions in LGA sessions	1.4	1.6	1.9	1.1	-1.4	-1.3
Extinction: sum of active levers before priming	0.8	0.8	1.9	0.5	-1.4	-0.5
Active lever presses in extinction session 6	3.0	2.9	3.1	1.7	-1.8	-1.6
Delta distance traveled before/after self-admin	1.6	1.7	2.0	1.2	-1.3	-1.4
Delta ambulatory time before/after self-admin	1.9	2.1	2.3	1.5	-1.3	-1.5
Time in closed arm before self-admin	0.5	0.6	1.6	-0.5	1.3	0.2
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	-0.1	0.0
Time in open arm before self-admin	0.9	1.0	1.5	1.0	-1.2	-0.7
Time in open arm after self-admin	0.8	0.8	1.1	-1.0	0.8	0.9
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.2	-0.1	0.0
Time to tail flick, vehicle, before self-admin	1.1	1.1	1.8	1.3	-0.4	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.0	-0.4	0.2
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.9	-0.0	-0.9
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.9	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.7	-1.2	0.4	1.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.0	-0.5	0.0
Ambulatory time before self-admin	0.2	0.2	0.2	-0.3	0.4	0.5
Ambulatory time after self-admin	0.5	0.5	0.6	0.8	-0.8	-0.7
Total heroin consumption	1.8	2.2	2.6	1.6	-1.5	-1.3
Area under the delay curve	1.8	1.9	2.6	-1.2	1.6	1.3
Delay disc. indifference point, 0s delay	5.4	5.9	10.1	-2.0	3.2	1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.4	0.2
Delay disc. indifference point, 2s delay	4.8	5.4	7.6	-2.1	2.8	2.1
Delay disc. indifference point, 24s delay	0.5	0.5	0.5	-0.7	0.7	0.7
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	-0.5	1.2	0.6
Delay disc. indifference point, 8s delay	1.2	1.3	1.6	-1.1	1.0	1.3
Delay discount exponential model param	1.7	1.8	2.3	1.2	-1.5	-1.3
Delay discount hyperbolic model param	2.4	2.5	3.4	1.4	-1.8	-1.5
Fecal boli incidents, locomotor time 1	2.2	2.4	3.2	-1.8	1.2	1.6
Change in fecal boli incidents, locomotor task	0.6	0.6	1.1	1.1	-0.3	-0.7
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	-0.2	0.7	-0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.2	-0.5	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.4	-0.5	-0.5
Rest time, locomotor task time 1	0.2	0.2	0.3	0.4	-0.4	-0.6
Distance moved, locomotor task time 1	0.2	0.2	0.7	-0.2	0.8	0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.3	0.2	0.4
Time >=10cm from walls, locomotor time 2	1.2	1.3	1.7	-1.3	0.9	1.2
Bouts of movement, locomotor time 2	0.8	0.9	1.4	1.1	-0.4	-1.2
Total resting periods, locomotor time 2	0.8	0.9	1.5	1.1	-0.3	-1.2
Rest time, locomotor task time 2	0.8	0.9	1.4	1.0	-0.6	-1.2
Distance moved, locomotor task time 2	1.0	1.2	1.6	-1.3	0.8	1.2
Vertical activity count, locomotor time 2	1.3	1.4	2.1	-1.4	0.6	1.3
Weight adjusted by age	0.5	0.5	0.9	-0.8	0.4	0.9
Seeking ratio, delayed vs. immediate footshock	5.2	5.9	7.0	2.6	-2.2	-2.5
Locomotion in novel chamber	0.3	0.3	0.6	0.6	-0.8	-0.1
Locomotion in novel chamber post-restriction	0.7	0.9	1.0	1.0	-0.9	-0.9
Progressive ratio	0.4	0.5	1.0	-0.5	0.4	1.0
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.3	0.3	0.7	0.3	-0.4	-0.9
Run reversals in cocaine runway, females	0.7	0.7	1.3	1.1	-0.5	-0.7
Run reversals in cocaine runway, males	1.4	1.4	1.9	1.4	-0.9	-1.2
Latency to leave start box in cocaine runway	1.6	1.7	2.2	1.5	-0.9	-1.5
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	0.8	0.2	-0.7
Latency to leave start box in cocaine runway, M	2.3	2.2	4.0	1.2	-2.0	-1.1
Cd content in liver	0.1	0.2	0.3	-0.3	0.5	0.3
Co content in liver	0.4	0.5	0.9	0.5	-0.9	-0.6
Cu content in liver	0.1	0.1	0.3	0.2	0.5	-0.2
Fe content in liver	0.0	0.0	0.0	-0.2	-0.2	0.1
K content in liver	0.2	0.2	0.3	0.5	0.2	-0.4
Mg content in liver	0.2	0.2	0.4	0.6	0.3	-0.4
Mn content in liver	2.3	2.6	4.0	2.0	-0.5	-1.9
Na content in liver	0.7	0.8	1.5	-0.7	1.2	0.6
Rb content in liver	0.2	0.3	0.8	0.0	0.9	0.0
Se content in liver	0.2	0.2	0.3	0.5	-0.4	-0.5
Sr content in liver	0.2	0.1	0.2	-0.5	-0.3	0.4
Zn content in liver	1.3	1.4	3.6	0.6	-1.9	-0.4