Folr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000019902	0.62	0.12	0.0e+00	0.5	0.5	0.5	0.5	4.2e-63	5.5e-64	1.4e-64	1.2e-63
2	Adipose	intron excision ratio	chr1:156228540:156229140	0.04	0.03	4.6e-04	0.02	0.02	0.02	0.02	9.4e-04	2.2e-03	2.3e-03	3.0e-03
3	Adipose	intron excision ratio	chr1:156228543:156229140	0.05	0.04	2.5e-04	0.03	0.02	0.02	0.02	6.4e-04	1.8e-03	1.6e-03	2.1e-03
4	Liver	gene expression	ENSRNOG00000019902	0.05	0.04	3.7e-04	0.02	0	-0	0	4.4e-03	1.5e-01	3.8e-01	9.3e-02
5	NAcc	gene expression	ENSRNOG00000019902	0.05	0.04	4.1e-03	0.02	0.02	0.02	0.01	7.1e-03	1.2e-02	1.3e-02	3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.0	3.2	8.3	2.9	0.7	-0.7	2.5	-0.5
BMI without tail	0.5	1.1	2.1	-0.0	-1.3	1.3	-0.3	1.4
Body weight	1.1	4.7	8.2	-0.9	-2.5	2.5	-1.3	2.9
Epididymis fat weight	0.1	0.3	0.6	0.3	-0.7	0.7	-0.0	0.8
Glucose	0.4	0.6	1.3	0.8	0.6	-0.6	1.1	-0.4
Heart weight	0.1	0.2	0.6	-0.8	-0.1	0.1	-0.4	0.3
Left kidney weight	0.9	2.5	4.0	-0.7	-1.9	1.9	-0.8	2.0
Right kidney weight	0.9	2.5	4.3	-0.8	-1.8	1.8	-0.9	2.1
Tail length	8.6	26.0	26.9	-5.2	-5.0	5.0	-5.2	5.1
Length with tail	5.8	21.2	25.0	-4.2	-4.7	4.7	-4.3	5.0
Length without tail	0.1	0.2	0.5	-0.0	-0.5	0.5	0.1	0.7
Liver weight, left	1.5	2.5	3.5	-1.4	-1.7	1.7	-1.2	1.9
Liver weight, right	3.5	5.9	7.2	-2.0	-2.6	2.6	-2.2	2.7
Parametrial fat weight	0.9	1.7	3.1	1.7	1.0	-1.0	1.8	-0.8
Retroperitoneal fat weight	0.9	2.9	5.9	0.3	-2.0	2.0	-0.3	2.4
Intraocular pressure	1.3	1.9	3.2	0.6	1.7	-1.7	0.7	-1.8
Extensor digitorum longus weight	0.1	0.3	0.6	0.6	-0.3	0.3	0.4	0.8
Soleus weight	0.4	1.2	1.7	-0.6	-1.3	1.3	-1.0	1.2
Tibialis anterior weight	0.5	1.9	3.8	-0.9	-1.4	1.4	-0.9	1.9
Tibia length	0.2	0.5	1.2	-1.1	-0.4	0.4	-0.8	0.5
Number of licking bursts	0.7	0.8	1.4	1.2	0.9	-0.9	0.8	-0.6
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.6	0.1	-0.1	-0.3	-0.3
Times rat made contact with spout	0.2	0.2	0.6	-0.3	-0.4	0.4	-0.4	0.8
Mean time between licks in bursts	8.3	11.5	13.2	-3.4	-3.6	3.6	-3.4	2.8
Mean num. licks in bursts	0.9	1.1	1.7	-1.3	-1.0	1.0	-1.0	1.0
Std. dev. time between licks in bursts	3.8	4.6	5.5	-2.0	-2.3	2.3	-2.0	1.9
Water consumed over 24 hours	0.2	0.2	0.5	0.5	0.7	-0.7	0.3	0.0
Indifference point 0 sec	0.3	0.5	0.7	-0.8	-0.7	0.7	-0.8	0.6
Indifference point AUC	0.5	0.6	0.7	-0.7	-0.8	0.8	-0.9	0.6
Indifference point function ln k	0.1	0.2	0.3	0.1	0.6	-0.6	0.4	-0.3
Indifference point function log k	0.1	0.2	0.3	0.1	0.6	-0.6	0.4	-0.3
Delay discounting total patch changes 0 sec	0.2	0.3	0.3	-0.5	-0.6	0.6	-0.6	0.5
Delay discounting total patch changes 12 sec	1.4	1.8	2.3	-1.1	-1.5	1.5	-1.3	1.3
Delay discounting total patch changes 18 sec	0.3	0.4	0.6	-0.8	-0.5	0.5	-0.8	0.2
Delay discounting total patch changes 24 sec	1.3	1.7	2.1	-1.2	-1.4	1.4	-1.2	1.2
Delay discounting total patch changes 6 sec	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.5	-0.1
Delay discounting time to switch 0 sec	0.9	1.4	1.7	1.1	1.3	-1.3	0.9	-1.2
Delay discounting water rate 0 sec	0.4	0.7	0.9	-0.9	-0.8	0.8	-0.8	0.6
Delay discounting water rate 12 sec	0.4	0.6	1.6	1.1	0.1	-0.1	1.3	-0.2
Delay discounting water rate 18 sec	0.7	0.9	1.5	-0.2	-1.2	1.2	0.0	1.2
Delay discounting water rate 24 sec	0.3	0.5	1.0	1.0	0.4	-0.4	1.0	-0.3
Delay discounting water rate 6 sec	0.2	0.2	0.8	0.6	0.0	-0.0	0.9	-0.1
Locomotor activity	0.1	0.1	0.2	0.1	-0.5	0.5	0.2	0.4
Locomotor testing distance	0.6	1.0	1.7	-0.5	-1.3	1.3	-0.2	1.2
Locomotor testing rearing	1.7	2.6	3.7	-1.1	-1.9	1.9	-1.0	1.9
Light reinforcement 1	2.1	3.8	6.0	2.4	1.7	-1.7	2.1	-1.8
Light reinforcement 2	4.4	5.8	7.4	2.6	2.1	-2.1	2.7	-2.3
Reaction time number correct	0.3	0.4	0.4	0.7	0.6	-0.6	0.5	-0.6
Reaction time mean minus median	0.5	0.6	0.8	-0.6	-0.9	0.9	-0.5	0.9
Reaction time mean minus median AUC	0.4	0.4	0.7	-0.5	-0.8	0.8	-0.4	0.8
Reaction time num false alarms	0.0	0.0	0.1	0.2	-0.1	0.1	-0.3	0.0
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	0.2	-0.2	-0.0	-0.3
Reaction time trials correct on left	0.3	0.4	0.4	0.7	0.6	-0.6	0.5	-0.6
Reaction time trials on left	0.3	0.5	0.6	0.7	0.7	-0.7	0.6	-0.7
Reaction time mean	0.4	0.6	1.1	-0.3	-0.9	0.9	-0.5	1.0
Reaction time mean AUC	0.3	0.3	0.6	-0.2	-0.7	0.7	-0.4	0.8
Median of all reaction times	0.2	0.3	0.6	0.0	-0.6	0.6	-0.2	0.8
Reaction time omissions	0.2	0.3	0.8	0.9	0.0	-0.0	0.7	0.0
Reaction time false alarm rate	0.0	0.0	0.1	0.3	-0.0	0.0	-0.0	-0.0
Reaction time premature initiation rate	2.0	2.7	3.3	-1.5	-1.8	1.8	-1.3	1.8
Reaction time premature initiations	0.5	0.8	1.1	-0.7	-1.0	1.0	-0.6	1.0
Std. dev. reaction times	1.5	2.1	2.8	-1.2	-1.6	1.6	-1.2	1.7
Reaction time trials completed	0.3	0.5	0.6	0.7	0.7	-0.7	0.6	-0.7
Reaction time trials AUC	0.1	0.2	0.3	0.6	0.4	-0.4	0.4	-0.4
Social response proportion	0.1	0.1	0.4	0.6	-0.2	0.2	-0.1	0.1
Social responses	0.6	0.8	1.3	-0.2	-1.1	1.1	-0.7	0.9
Social time	1.3	1.8	2.5	1.2	1.3	-1.3	1.1	-1.6
Conditioned locomotion	0.2	0.3	0.5	-0.5	-0.7	0.7	-0.5	0.3
Cocaine response after cond. corrected	0.2	0.2	0.6	0.8	0.1	-0.1	0.5	0.5
Cocaine response after cond. not corrected	0.6	0.7	1.4	1.2	0.7	-0.7	1.0	-0.2
Cocaine response before conditioning	0.7	0.9	1.5	0.5	0.9	-0.9	0.9	-1.2
Saline control response	3.3	4.3	5.8	-2.4	-2.0	2.0	-2.2	1.6
Condit. Reinf. active minus inactive responses	4.9	6.0	7.0	-2.6	-2.6	2.6	-2.2	2.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	-0.7	-0.7	0.7	-0.5	0.5
Condit. Reinf. active responses	7.2	10.0	11.2	-3.3	-3.3	3.3	-2.9	2.9
Condit. Reinf. inactive responses	5.2	6.4	7.1	-2.6	-2.7	2.7	-2.4	2.4
Condit. Reinf. lever presses	5.4	7.5	8.8	-2.8	-3.0	3.0	-2.2	2.7
Condit. Reinf. lever reinforcers received	6.8	9.6	11.1	-3.3	-3.2	3.2	-2.8	2.9
Pavlov. Cond. lever latency	4.0	5.5	7.6	2.3	2.8	-2.8	1.6	-2.2
Pavlov. Cond. magazine entry latency	0.3	0.4	1.1	0.8	-0.2	0.2	1.0	-0.3
Pavlov. Cond. change in total contacts	2.6	3.6	5.0	-1.9	-2.2	2.2	-1.3	1.7
Pavlov. Cond. index score	2.0	2.6	4.3	-1.4	-2.1	2.1	-0.8	1.4
Pavlov. Cond. latency score	1.3	1.7	3.0	-1.0	-1.7	1.7	-0.4	1.1
Pavlov. Cond. lever contacts	4.6	6.4	8.1	-2.5	-2.9	2.9	-1.9	2.4
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.1	0.6	-0.6	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	2.0	2.6	3.3	-1.7	-1.5	1.5	-1.8	1.5
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	4.5	-1.4	-2.1	2.1	-0.9	1.5
Pavlov. Cond. response bias	3.3	4.6	6.5	-2.1	-2.5	2.5	-1.4	1.9
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.0	0.5	-0.5	0.3	-0.2
Conditioned reinforcement - inactives	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.4	0.5
Conditioned locomotion	0.3	0.4	0.6	0.3	0.7	-0.7	0.6	-0.8
Intermittent access intake day 1-15 change	1.0	1.0	1.7	1.2	0.8	-0.8	1.3	-0.7
Intermittent access intake escalation	1.3	1.2	2.2	1.3	0.9	-0.9	1.5	-0.8
Intermittent access intake escalation 2	0.4	0.4	1.1	0.9	0.2	-0.2	1.0	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.5	0.3
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.1	0.3	-0.3	-0.1	-0.3
Intermitt. access escalation Index	0.4	0.3	0.4	-0.5	-0.6	0.6	-0.6	0.4
Intermittent access day 1 total infusions	0.9	1.0	1.8	-1.4	-0.9	0.9	-1.0	0.8
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.3	-0.2	0.2	0.1	0.2
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.6	-0.5	0.5	-0.2	0.5
Intermittent access total infusions	0.4	0.4	0.6	-0.7	-0.7	0.7	-0.5	0.6
Intermittent access day 1 locomotion	0.2	0.2	0.4	-0.7	0.4	-0.4	-0.5	-0.1
Intermittent access day 15 total locomotion	0.6	0.6	1.1	0.4	1.1	-1.1	0.5	-0.7
Intermittent access total locomotion	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.2	0.1
Intermittent access standard deviation	0.4	0.4	1.1	1.0	0.2	-0.2	1.0	-0.3
Cocaine induced anxiety	0.2	0.2	0.3	0.2	0.6	-0.6	-0.3	-0.6
Post-drug Anxiety	1.0	1.1	2.7	-1.3	-0.7	0.7	-1.6	0.7
Baseline Anxiety	1.7	1.8	2.9	-1.7	-1.2	1.2	-1.4	1.2
Lifetime Intake	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.3	0.6
Incentive Sensitization - Responses	1.3	1.3	1.5	-1.2	-1.1	1.1	-1.0	1.2
Incentive Sensitization - Breakpoint	0.7	0.7	1.0	-0.8	-0.9	0.9	-0.7	1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.3	-0.3	-0.0	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.2	-0.0
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.2	0.2	0.0	0.2
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	-1.0	-0.5	0.5	-0.7	0.6
Progressive ratio test 2 breakpoint	0.5	0.6	1.1	-1.0	-0.6	0.6	-0.8	0.7
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	0.1
Total sessions with >9 infusions	0.1	0.1	0.3	-0.0	0.3	-0.3	0.6	-0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.6	0.3	-0.3	-0.5	-0.1
Short access day 10 total inactive lever presses	0.2	0.2	0.3	0.6	0.5	-0.5	0.3	-0.5
Short access day 1 total infusions	0.7	0.7	1.3	-1.1	-0.7	0.7	-0.6	1.0
Short access day 10 total infusions	0.6	0.7	0.9	-1.0	-0.8	0.8	-0.6	0.8
Short access total infusions	0.4	0.4	0.6	-0.8	-0.6	0.6	-0.3	0.7
Short access day 1 locomotion	1.5	1.5	2.3	0.6	1.5	-1.5	1.2	-1.2
Short access day 10 total locomotion	0.1	0.2	0.3	0.6	0.3	-0.3	0.4	0.1
Short access total locomotion	0.3	0.3	0.4	0.3	0.7	-0.7	0.5	-0.4
Compulsive drug intake	1.1	1.1	1.4	0.9	1.1	-1.1	0.9	-1.2
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.1	-0.6	0.6	0.4	0.6
One hour access (shock baseline)	1.0	1.1	1.7	-0.7	-1.3	1.3	-0.4	1.3
Number of responses in last shaping day	0.6	0.6	1.6	-1.2	-0.4	0.4	-0.8	0.7
Context. condit. distance diff. score	0.3	0.3	0.5	-0.5	-0.7	0.7	-0.1	0.7
Locomotion velocity, session 1	2.2	2.4	2.8	1.7	1.5	-1.5	1.7	-1.3
Locomotion distance, session 1	0.4	0.5	0.9	0.9	0.6	-0.6	1.0	-0.3
Locomotion velocity, session 2	0.6	0.7	1.3	1.1	0.4	-0.4	1.1	-0.7
Locomotion distance, session 2	0.5	0.7	1.5	1.2	0.2	-0.2	1.2	-0.7
Locomotion velocity, session 3	0.1	0.1	0.4	-0.5	-0.1	0.1	-0.2	-0.6
Locomotion distance, session 3	0.3	0.4	1.0	-0.3	0.6	-0.6	0.1	-1.0
Stereotopy head waving bouts, day 3	0.5	0.6	0.9	-0.6	-0.8	0.8	-0.9	0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.2	0.2	-0.2	-0.0	-0.2
Locomotion velocity, session 7	0.7	0.8	1.3	1.1	0.5	-0.5	1.1	-0.9
Locomotion distance, session 7	0.0	0.1	0.1	0.1	-0.3	0.3	0.1	0.1
Stereotopy head waving bouts, day 7	0.3	0.3	1.1	-1.0	0.0	-0.0	-0.7	-0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.7	-0.8	0.0	-0.0	-0.5	-0.4
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	-0.8	0.8	-0.3	0.7
Locomotion distance, session 8	0.2	0.2	0.5	0.0	-0.7	0.7	0.3	0.3
Degree of sensitization distance	2.3	2.3	3.8	-0.5	-1.8	1.8	-0.8	2.0
Degree of sensitization stereotypy	0.5	0.5	2.0	-1.4	-0.2	0.2	-0.8	-0.1
Condit. Reinf. active minus inactive responses	2.0	2.3	2.9	-1.6	-1.5	1.5	-1.7	1.2
Condit. Reinf. active-inactive response ratio	3.3	3.6	5.3	-2.3	-1.6	1.6	-2.3	1.4
Condit. Reinf. active responses	1.0	1.2	1.8	-1.2	-1.1	1.1	-1.3	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.4	0.6	0.2	-0.2	0.5	-0.1
Incentive salience index mean	1.1	1.3	2.1	-1.3	-1.1	1.1	-1.4	0.8
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.2	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.1	-0.5	0.5	-0.1	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.4	-0.0	0.0	-0.5	0.2
Total zone transitions, hab. session 1	0.5	0.6	1.1	0.4	0.9	-0.9	0.6	-1.0
Total locomotion distance, hab. session 1	1.3	1.9	2.6	-0.8	-1.5	1.5	-1.2	1.6
Locomotion velocity, hab. session 1	0.8	1.2	1.7	-0.5	-1.3	1.3	-0.9	1.2
Time in familiar zone, hab. session 2	3.3	3.4	3.6	-1.8	-1.9	1.9	-1.8	1.9
Time in novel zone, hab. session 2	3.5	3.6	4.4	2.1	1.7	-1.7	2.1	-1.8
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.2
Total locomotion distance, hab. session 2	2.8	3.7	5.6	-1.0	-2.4	2.4	-1.3	2.1
Locomotion velocity, hab. session 2	2.9	3.9	5.9	-1.0	-2.4	2.4	-1.3	2.2
Novel to familiar place preference ratio	1.9	2.0	3.7	-1.7	-1.2	1.2	-1.9	0.7
Novelty place preference	1.9	1.9	3.3	-1.7	-1.2	1.2	-1.8	0.7
Time in novel zone, NPP test	2.2	2.3	3.8	-1.8	-1.4	1.4	-1.9	0.9
Total zone transitions, NPP test	1.1	1.6	2.3	1.4	1.2	-1.2	1.5	-1.1
Total locomotion distance, NPP test	0.4	0.5	0.9	1.0	-0.7	0.7	0.5	0.7
Locomotion velocity, NPP test	0.4	0.5	1.5	1.2	-0.5	0.5	0.8	0.4
Pavlov. Cond. lever latency	0.5	0.7	1.3	1.1	0.6	-0.6	1.0	-0.3
Pavlov. Cond. magazine entry latency	1.2	1.6	2.1	-1.2	-1.4	1.4	-0.9	1.2
Pavlov. Cond. change in total contacts	1.6	1.7	3.2	-1.8	-1.0	1.0	-1.6	0.9
Pavlov. Cond. index score	0.9	1.2	1.8	-1.3	-1.1	1.1	-1.1	0.7
Pavlov. Cond. latency score	1.0	1.3	2.0	-1.4	-1.1	1.1	-1.2	0.8
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-0.9	-0.6	0.6	-0.8	0.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	1.2	1.0	-1.0	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	0.4	-0.4	0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-1.2	-0.8	0.8	-1.0	0.4
Pavlov. Cond. response bias	0.5	0.6	0.7	-0.8	-0.8	0.8	-0.6	0.6
Bone: apparent density	0.4	0.7	1.3	0.1	1.1	-1.1	0.3	-1.1
Bone surface	0.4	0.7	2.0	-1.4	-0.4	0.4	-1.1	0.4
Bone volume	0.3	0.6	1.4	-1.2	-0.5	0.5	-1.0	0.4
Bone: connectivity density	1.8	2.8	3.7	1.2	1.9	-1.9	1.5	-1.8
Bone: cortical apparent density	0.4	0.5	1.1	0.0	-0.8	0.8	-0.4	1.1
Bone: cortical area	0.9	1.3	1.8	-0.9	-1.3	1.3	-0.8	1.3
Bone: cortical porosity	0.2	0.2	0.5	-0.7	0.4	-0.4	-0.5	-0.0
Bone: cortical porosity	0.2	0.2	0.6	-0.8	0.2	-0.2	-0.5	0.1
Bone: cortical thickness	0.2	0.4	1.0	1.0	0.2	-0.2	0.9	-0.1
Bone: cortical thickness	0.1	0.1	0.2	-0.0	-0.2	0.2	-0.0	0.4
Bone: cortical tissue density	0.3	0.4	1.1	0.1	-0.7	0.7	-0.4	1.0
Bone: elastic displacement	3.1	3.5	3.9	1.8	1.9	-1.9	1.7	-2.0
Bone: elastic work	6.3	8.1	8.8	2.8	2.9	-2.9	2.7	-3.0
Bone: endosteal estimation	1.9	4.1	5.5	-2.3	-1.9	1.9	-1.9	2.0
Bone: endosteal perimeter	1.7	3.5	5.0	-2.2	-1.8	1.8	-1.8	1.7
Bone: final force	1.0	1.7	2.3	-1.4	-1.1	1.1	-1.5	1.4
Bone: final moment	1.0	1.6	2.1	-1.4	-1.1	1.1	-1.5	1.3
Bone: marrow area	1.8	3.8	5.0	-2.2	-1.8	1.8	-1.9	2.0
Bone: maximum diameter	2.0	3.7	4.3	-2.1	-1.9	1.9	-1.7	1.9
Bone: maximum force	0.6	1.1	1.6	-1.3	-0.8	0.8	-1.2	1.1
Bone: maximum moment	0.4	0.8	1.2	-1.1	-0.7	0.7	-1.0	0.8
Bone: minimum diameter	2.5	4.6	5.3	-2.0	-2.3	2.3	-1.9	2.2
Bone: periosteal estimation	1.4	2.9	3.4	-1.8	-1.7	1.7	-1.5	1.8
Bone: periosteal perimeter	1.2	1.9	2.2	-1.5	-1.4	1.4	-1.1	1.5
Bone: post-yield work	0.2	0.3	0.5	-0.4	-0.6	0.6	-0.1	0.7
Bone: stiffness	2.2	3.4	4.9	-2.0	-1.5	1.5	-2.2	1.8
Bone: tissue strength	4.2	4.1	5.8	1.9	1.9	-1.9	1.9	-2.4
Bone: trabecular number	1.6	2.5	3.3	1.2	1.8	-1.8	1.3	-1.8
Bone: trabecular spacing	0.2	0.3	0.6	0.8	0.3	-0.3	0.8	-0.4
Bone: trabecular thickness	1.6	2.0	3.0	-1.6	-1.2	1.2	-1.7	1.0
Bone: trabecular tissue density	3.8	5.4	6.6	-2.1	-2.3	2.3	-2.6	2.4
Breakpoint value in progressive ratio session	0.6	0.7	1.1	1.1	0.7	-0.7	1.1	-0.4
Distance traveled before self-admin	1.0	1.1	1.6	1.3	1.0	-1.0	1.2	-0.7
Distance traveled after self-admin	0.5	0.5	1.5	0.7	0.4	-0.4	1.2	-0.6
Delta time in closed arm before/after self-admin	1.0	1.0	1.3	-0.4	-1.1	1.1	-1.0	1.1
Delta time in open arm before/after self-admin	1.5	1.5	2.9	-1.7	-1.1	1.1	-1.2	0.7
Diff in mean of infusions in LGA sessions	0.3	0.3	1.0	-0.7	0.3	-0.3	-1.0	0.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	-0.3	0.3	0.5	0.1
Active lever presses in extinction session 6	0.5	0.5	0.8	0.3	0.8	-0.8	0.4	-0.9
Delta distance traveled before/after self-admin	2.2	2.3	3.7	-1.9	-1.5	1.5	-1.4	1.2
Delta ambulatory time before/after self-admin	1.1	1.2	2.2	-1.5	-1.1	1.1	-1.0	0.7
Time in closed arm before self-admin	0.1	0.1	0.2	0.1	0.3	-0.3	0.5	-0.3
Time in closed arm after self-admin	0.4	0.4	0.7	0.3	0.8	-0.8	0.0	-0.7
Time in open arm before self-admin	1.7	1.8	3.1	1.8	1.3	-1.3	1.2	-1.0
Time in open arm after self-admin	0.5	0.5	0.8	-0.5	-0.9	0.9	-0.5	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.4	-0.4	0.4	0.6	0.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	0.1
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.1	-1.0	0.2	-0.2	-0.5	-0.2
Time to tail flick, test, before self-admin	1.6	1.5	2.4	-1.6	-1.1	1.1	-1.5	0.9
Time to tail flick, test, after self-admin	4.1	4.2	5.6	-2.2	-1.8	1.8	-2.4	2.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.2	0.6	-0.6	-0.1	-0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.1	0.1	0.2	0.2
Ambulatory time before self-admin	1.2	1.3	1.6	1.2	1.2	-1.2	1.2	-0.9
Ambulatory time after self-admin	0.2	0.2	0.4	0.1	0.4	-0.4	0.7	-0.4
Total heroin consumption	0.2	0.3	0.5	0.2	-0.6	0.6	0.2	0.7
Area under the delay curve	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3	-0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.3	0.5
Delay disc. indifference point, 16s delay	0.4	0.4	1.0	-0.8	-0.4	0.4	-1.0	0.1
Delay disc. indifference point, 2s delay	1.2	1.3	1.5	-1.2	-1.2	1.2	-1.1	1.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.0	-0.1	0.1	-0.3	0.1
Delay disc. indifference point, 4s delay	1.8	1.9	2.4	-1.1	-1.6	1.6	-1.1	1.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.1	0.2	-0.2	0.0	-0.3
Delay discount exponential model param	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	0.2
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.0
Fecal boli incidents, locomotor time 1	0.6	0.7	1.6	0.1	1.0	-1.0	0.2	-1.3
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.1	-0.7	0.7	-0.3	0.7
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.9	-0.4	0.4	-0.9	0.2
Bouts of movement, locomotor time 1	0.4	0.4	0.9	-0.9	0.4	-0.4	-0.9	-0.1
Total resting periods, locomotor time 1	0.4	0.4	0.7	-0.3	0.8	-0.8	-0.4	-0.7
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.8	-0.0	0.0	-0.8	-0.1
Distance moved, locomotor task time 1	0.2	0.2	0.6	0.4	-0.3	0.3	0.3	0.8
Vertical activity count, locomotor time 1	0.4	0.4	1.2	-0.1	-0.6	0.6	-0.2	1.1
Time >=10cm from walls, locomotor time 2	4.0	4.3	4.9	-2.1	-2.2	2.2	-1.9	1.9
Bouts of movement, locomotor time 2	2.4	2.5	4.1	-1.8	-1.2	1.2	-2.0	1.5
Total resting periods, locomotor time 2	1.3	1.4	2.7	-1.4	-0.7	0.7	-1.6	1.2
Rest time, locomotor task time 2	1.6	1.8	2.4	1.3	1.5	-1.5	1.0	-1.3
Distance moved, locomotor task time 2	2.0	2.3	3.1	-1.2	-1.8	1.8	-1.0	1.7
Vertical activity count, locomotor time 2	2.2	2.4	3.0	-1.2	-1.7	1.7	-1.3	1.6
Weight adjusted by age	0.5	0.6	1.0	-0.7	-0.7	0.7	-0.6	1.0
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	2.3	1.3	1.5	-1.5	1.4	-1.5
Locomotion in novel chamber	2.3	2.9	3.3	1.8	1.8	-1.8	1.8	-1.3
Locomotion in novel chamber post-restriction	0.4	0.4	0.7	0.2	0.7	-0.7	0.6	-0.8
Progressive ratio	0.9	1.0	1.3	0.7	1.2	-1.2	1.0	-1.0
Food seeking constrained by brief footshock	1.8	2.2	2.6	-1.3	-1.6	1.6	-1.4	1.5
Seeking ratio, punishment vs. effort	3.0	3.7	4.7	-1.4	-2.2	2.2	-1.7	2.1
Run reversals in cocaine runway, females	1.5	1.5	2.6	-0.3	-1.5	1.5	-0.6	1.6
Run reversals in cocaine runway, males	0.1	0.1	0.5	0.2	0.3	-0.3	0.2	-0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.1	0.6	-0.6	-0.1	-0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	-0.4	-0.1	0.1	-0.7	0.2
Latency to leave start box in cocaine runway, M	1.4	1.3	2.0	0.7	1.3	-1.3	0.7	-1.4
Cd content in liver	0.1	0.2	0.5	0.2	0.3	-0.3	0.3	-0.7
Co content in liver	4.2	4.9	6.6	-2.6	-2.1	2.1	-2.5	1.8
Cu content in liver	2.2	2.6	3.4	-1.9	-1.5	1.5	-1.8	1.5
Fe content in liver	0.4	0.5	1.1	-1.0	-0.4	0.4	-1.0	0.2
K content in liver	0.1	0.1	0.2	0.5	-0.2	0.2	0.1	0.1
Mg content in liver	0.0	0.0	0.1	0.3	-0.1	0.1	0.2	0.1
Mn content in liver	2.4	2.7	3.1	1.7	1.7	-1.7	1.8	-1.4
Na content in liver	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.0	-0.3
Rb content in liver	0.6	0.8	1.4	-1.2	-0.5	0.5	-1.0	0.9
Se content in liver	1.5	1.8	2.5	1.1	1.6	-1.6	1.1	-1.2
Sr content in liver	2.1	1.9	2.4	1.4	1.2	-1.2	1.4	-1.5
Zn content in liver	0.1	0.1	0.1	-0.0	-0.3	0.3	0.2	0.3