Art2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000019687	0.07	0.04	2.3e-06	0.04	0.04	0.03	0.04	1.3e-05	6.7e-05	1.8e-04	7.0e-05
2	Liver	gene expression	ENSRNOG00000019687	0.05	0.04	2.7e-04	0.03	0.02	0.03	0.02	2.6e-04	1.9e-03	1.9e-04	9.2e-04
3	Liver	isoform ratio	ENSRNOT00000026644	0.03	0.02	4.8e-03	0.01	0.01	-0	0.01	7.1e-02	1.6e-02	3.8e-01	4.4e-02
4	NAcc	gene expression	ENSRNOG00000019687	0.12	0.07	7.6e-07	0.09	0.07	0.07	0.09	3.1e-07	4.0e-06	6.2e-06	5.7e-07
5	OFC	gene expression	ENSRNOG00000019687	0.54	0.2	3.3e-03	-0.01	0.01	0.02	-0	6.6e-01	1.4e-01	1.2e-01	4.3e-01
6	PL	gene expression	ENSRNOG00000019687	0.09	0.07	8.9e-04	0	0.02	0.01	0.01	1.2e-01	1.3e-02	2.8e-02	7.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.9	3.1	6.1	-1.1	-0.8	-2.0	0.9	-2.5	2.4
BMI without tail	0.8	1.7	6.0	1.0	1.1	0.7	-1.1	-2.4	-0.3
Body weight	0.6	2.5	6.1	0.9	2.1	1.5	-1.1	-2.5	-0.7
Epididymis fat weight	0.2	0.5	0.8	-0.8	-0.0	-0.2	0.8	-0.8	0.9
Glucose	0.1	0.1	0.4	0.1	-0.4	-0.6	0.0	-0.1	0.3
Heart weight	0.7	1.0	1.7	1.3	0.7	0.9	-1.1	-0.3	-1.2
Left kidney weight	1.0	2.9	6.1	1.6	1.6	1.5	-1.7	-2.5	-1.1
Right kidney weight	0.6	1.7	3.6	1.1	1.2	1.3	-1.1	-1.9	-0.8
Tail length	6.2	18.8	28.9	4.2	4.7	5.4	-4.1	-1.9	-5.0
Length with tail	3.2	11.8	19.8	2.9	4.2	4.4	-2.9	-1.8	-3.7
Length without tail	0.0	0.1	0.3	-0.5	0.3	0.0	0.4	-0.0	0.3
Liver weight, left	0.4	0.6	1.1	-1.0	0.4	0.8	1.0	1.1	-0.0
Liver weight, right	0.4	0.7	2.1	-0.7	1.0	1.4	0.4	0.6	-0.4
Parametrial fat weight	0.8	1.6	2.9	-1.3	-1.0	-1.5	1.3	-0.3	1.7
Retroperitoneal fat weight	0.6	1.9	2.9	-1.7	0.6	-0.1	1.6	-1.7	1.7
Intraocular pressure	0.8	1.1	3.0	-0.2	-1.7	-1.0	0.2	1.5	0.2
Extensor digitorum longus weight	0.1	0.3	0.6	-0.5	-0.0	-0.3	0.6	-0.7	0.8
Soleus weight	0.1	0.4	0.8	-0.5	0.9	0.6	0.4	-0.8	0.3
Tibialis anterior weight	0.2	0.6	1.1	0.5	1.1	1.0	-0.5	-0.8	-0.6
Tibia length	0.5	1.5	2.8	1.3	1.1	1.1	-1.4	0.4	-1.7
Number of licking bursts	2.9	3.4	5.5	-2.3	-1.3	-1.6	2.3	1.0	2.1
Food consumed during 24 hour testing period	1.7	2.1	3.9	2.0	0.9	0.9	-1.9	-0.4	-1.7
Times rat made contact with spout	0.1	0.1	0.2	-0.4	0.4	0.1	0.3	0.4	0.0
Mean time between licks in bursts	7.3	10.2	14.7	3.0	3.6	3.8	-2.9	-2.2	-3.3
Mean num. licks in bursts	2.6	3.2	5.0	2.1	1.4	1.6	-2.2	-0.8	-2.1
Std. dev. time between licks in bursts	2.2	2.6	4.6	1.3	2.0	2.1	-1.2	-1.2	-1.6
Water consumed over 24 hours	0.6	0.7	1.0	-0.9	-0.7	-0.8	0.9	1.0	0.7
Indifference point 0 sec	1.7	2.7	4.1	1.9	1.6	1.3	-2.0	-1.3	-1.6
Indifference point AUC	0.5	0.5	0.8	0.7	0.9	0.9	-0.6	-0.7	-0.6
Indifference point function ln k	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.4	0.5	-0.3
Indifference point function log k	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.4	0.5	-0.3
Delay discounting total patch changes 0 sec	1.3	2.1	3.3	1.7	1.4	1.1	-1.8	-1.4	-1.3
Delay discounting total patch changes 12 sec	1.5	2.0	3.0	1.3	1.7	1.5	-1.3	-1.3	-1.2
Delay discounting total patch changes 18 sec	0.9	1.2	1.8	1.2	1.0	1.0	-1.4	-0.7	-1.1
Delay discounting total patch changes 24 sec	1.5	1.9	2.5	1.3	1.6	1.5	-1.3	-1.3	-1.2
Delay discounting total patch changes 6 sec	0.3	0.5	1.0	0.8	0.5	0.5	-0.9	-1.0	-0.5
Delay discounting time to switch 0 sec	3.1	4.7	6.6	-2.6	-2.0	-1.7	2.6	2.0	2.0
Delay discounting water rate 0 sec	2.0	3.2	4.9	2.2	1.5	1.4	-2.2	-1.5	-1.7
Delay discounting water rate 12 sec	1.4	2.0	6.7	1.5	0.7	-0.1	-1.7	-2.6	-0.2
Delay discounting water rate 18 sec	2.6	3.5	6.6	2.2	1.5	1.2	-2.1	-2.6	-1.3
Delay discounting water rate 24 sec	0.2	0.3	1.1	0.4	-0.1	-0.5	-0.5	-1.0	0.3
Delay discounting water rate 6 sec	0.5	0.7	2.0	0.8	0.4	-0.1	-1.0	-1.4	-0.2
Locomotor activity	0.5	0.7	2.2	0.9	0.7	0.4	-0.8	-1.5	-0.3
Locomotor testing distance	1.9	3.2	5.6	1.9	1.7	1.3	-1.8	-2.4	-1.3
Locomotor testing rearing	1.4	2.2	3.3	1.4	1.8	1.6	-1.3	-1.7	-1.2
Light reinforcement 1	2.5	4.6	7.6	-2.2	-2.0	-2.4	2.4	0.1	2.8
Light reinforcement 2	1.4	1.9	4.1	-0.6	-1.6	-2.0	0.9	-0.8	1.7
Reaction time number correct	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.3	-0.1	0.3
Reaction time mean minus median	0.5	0.6	0.8	0.7	0.9	0.9	-0.7	-0.8	-0.7
Reaction time mean minus median AUC	0.4	0.5	0.7	0.7	0.8	0.8	-0.8	-0.6	-0.7
Reaction time num false alarms	1.3	1.8	4.2	-1.9	-0.6	-0.7	2.0	0.8	1.4
Reaction time num false alarms AUC	1.4	1.9	4.1	-1.8	-0.7	-0.8	2.0	1.0	1.4
Reaction time trials correct on left	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.3	-0.1	0.3
Reaction time trials on left	0.1	0.1	0.3	-0.2	-0.3	-0.5	-0.2	-0.1	0.4
Reaction time mean	0.5	0.7	1.9	-1.4	-0.1	-0.1	1.2	0.6	0.8
Reaction time mean AUC	0.7	1.0	2.3	-1.5	-0.3	-0.2	1.3	1.0	0.8
Median of all reaction times	1.1	1.5	3.2	-1.8	-0.5	-0.5	1.7	0.9	1.2
Reaction time omissions	0.5	0.7	1.4	-1.2	-0.3	-0.7	0.9	-0.4	1.2
Reaction time false alarm rate	1.3	1.8	4.5	-1.7	-0.6	-0.7	2.1	0.7	1.3
Reaction time premature initiation rate	2.1	2.8	3.4	1.7	1.7	1.9	-1.7	-1.5	-1.6
Reaction time premature initiations	1.1	1.6	2.3	1.3	1.3	1.2	-1.5	-1.3	-1.1
Std. dev. reaction times	0.3	0.5	1.2	0.0	1.0	1.1	-0.1	-0.0	-0.6
Reaction time trials completed	0.1	0.1	0.3	-0.2	-0.3	-0.5	-0.2	-0.1	0.4
Reaction time trials AUC	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.3	-0.3	0.3
Social response proportion	0.5	0.5	1.0	-0.8	0.2	-0.4	0.6	-1.0	1.0
Social responses	0.4	0.5	1.3	-0.5	1.1	0.4	0.2	-1.1	0.5
Social time	1.7	2.2	3.0	-1.7	-1.2	-1.5	1.7	0.8	1.7
Conditioned locomotion	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.3	0.0
Cocaine response after cond. corrected	1.0	1.2	1.9	-1.4	-0.8	-0.9	1.4	0.1	1.4
Cocaine response after cond. not corrected	0.9	1.0	1.6	-1.0	-1.0	-1.2	1.0	0.0	1.3
Cocaine response before conditioning	0.4	0.5	1.4	1.1	-0.3	-0.2	-1.2	-0.3	-0.6
Saline control response	3.3	4.4	6.4	2.0	2.3	2.5	-2.1	-0.6	-2.5
Condit. Reinf. active minus inactive responses	8.7	10.8	13.6	3.6	3.2	3.3	-3.7	-2.0	-3.6
Condit. Reinf. active-inactive response ratio	1.5	1.5	2.4	1.5	1.0	1.1	-1.6	-0.7	-1.4
Condit. Reinf. active responses	11.3	15.7	18.2	4.2	4.1	4.1	-4.3	-2.5	-4.3
Condit. Reinf. inactive responses	6.7	8.3	11.5	2.8	3.4	3.1	-2.8	-2.0	-3.0
Condit. Reinf. lever presses	14.5	19.9	26.6	5.1	4.2	4.1	-5.2	-3.3	-4.7
Condit. Reinf. lever reinforcers received	11.6	16.4	19.8	4.4	4.2	4.1	-4.4	-2.4	-4.4
Pavlov. Cond. lever latency	15.2	20.8	29.0	-5.3	-4.1	-3.8	5.4	4.1	4.4
Pavlov. Cond. magazine entry latency	2.7	3.1	8.1	2.0	1.1	0.4	-2.1	-2.8	-0.8
Pavlov. Cond. change in total contacts	12.7	17.7	25.4	5.0	3.7	3.3	-5.0	-3.7	-4.1
Pavlov. Cond. index score	10.8	14.1	19.9	4.4	3.3	2.9	-4.5	-3.8	-3.4
Pavlov. Cond. latency score	9.3	11.8	17.0	4.0	3.0	2.5	-4.1	-3.7	-3.0
Pavlov. Cond. lever contacts	15.3	21.3	29.7	5.3	4.2	3.9	-5.4	-3.9	-4.6
Pavlov. Cond. magazine entry number	4.8	5.9	9.2	-3.0	-1.8	-1.3	3.0	2.9	1.9
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.9	0.5	1.1	1.4	-0.5	0.3	-1.1
Pavlov. Cond. lever-magazine prob. diff.	10.6	13.7	19.1	4.3	3.3	2.9	-4.4	-3.8	-3.4
Pavlov. Cond. response bias	15.1	20.8	29.6	5.3	4.1	3.7	-5.4	-4.2	-4.4
Conditioned reinforcement - actives	0.2	0.2	0.4	0.5	0.4	0.1	-0.6	0.2	-0.5
Conditioned reinforcement - inactives	0.2	0.2	0.5	-0.7	0.2	0.2	0.6	0.6	0.2
Conditioned locomotion	0.5	0.5	1.3	1.1	0.4	0.0	-1.1	-0.4	-0.6
Intermittent access intake day 1-15 change	0.5	0.4	1.7	0.5	0.4	-0.5	-0.5	-1.3	0.3
Intermittent access intake escalation	0.4	0.4	1.2	0.3	0.3	-0.7	-0.6	-1.1	0.4
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.3	0.1	-0.6	0.2	-0.9	0.7
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.1	-1.5	-0.2	-0.3	1.1	1.2	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	0.4	0.5	0.2	-0.5	0.1	-0.4
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	0.4	0.4	-0.4	0.2	-0.4
Intermittent access day 1 total infusions	1.4	1.6	2.7	1.3	1.2	1.4	-1.3	0.2	-1.6
Intermittent access day 15 total infusions	0.8	0.8	1.4	0.9	1.2	0.7	-1.1	-0.4	-0.9
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.7	1.0	1.3	0.9	-1.1	-0.4	-1.1
Intermittent access total infusions	0.8	0.9	1.3	0.9	1.1	0.9	-1.0	-0.1	-1.1
Intermittent access day 1 locomotion	0.4	0.4	2.0	0.0	0.3	0.3	-0.2	1.4	-0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.5	0.6	0.5	-0.1	-0.7	0.2	-0.4
Intermittent access total locomotion	0.5	0.5	0.9	0.7	1.0	0.5	-0.9	-0.0	-0.8
Intermittent access standard deviation	0.3	0.3	0.6	-0.5	0.1	-0.7	0.3	-0.8	0.8
Cocaine induced anxiety	2.6	3.0	5.0	-2.2	-1.3	-1.1	2.2	1.8	1.5
Post-drug Anxiety	0.3	0.4	1.3	-0.4	0.1	0.7	0.5	1.1	-0.3
Baseline Anxiety	2.8	2.9	4.5	1.9	1.5	1.8	-1.9	-0.3	-2.1
Lifetime Intake	1.1	1.2	1.7	1.2	1.2	1.0	-1.3	-0.4	-1.3
Incentive Sensitization - Responses	1.5	1.5	2.8	1.0	1.7	1.4	-1.1	-0.2	-1.4
Incentive Sensitization - Breakpoint	1.1	1.1	2.3	0.9	1.5	1.1	-1.0	-0.3	-1.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.2	0.1	0.2	-0.2	0.3	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.2	0.2	0.3	-0.2	0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.1	0.5	0.3	-0.2	0.3	-0.4
Progressive ratio test 2 active lever presses	0.7	0.8	1.4	0.6	1.2	1.0	-0.7	0.5	-1.1
Progressive ratio test 2 breakpoint	0.8	0.9	1.7	0.7	1.3	1.1	-0.8	0.4	-1.2
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	0.3	0.7	0.4	-0.5	0.3	-0.6
Total sessions with >9 infusions	1.9	2.0	3.9	2.0	0.9	0.7	-1.9	-1.2	-1.3
Short access day 1 total inactive lever presses	0.5	0.6	2.8	-0.7	0.1	0.1	0.5	1.7	-0.1
Short access day 10 total inactive lever presses	0.9	1.0	1.6	-1.2	-0.7	-0.8	1.2	0.8	1.0
Short access day 1 total infusions	2.0	2.1	2.8	1.7	1.4	1.5	-1.6	-0.7	-1.7
Short access day 10 total infusions	1.7	1.8	2.5	1.4	1.5	1.3	-1.6	-0.5	-1.5
Short access total infusions	1.4	1.6	2.2	1.5	1.1	1.2	-1.5	-0.7	-1.4
Short access day 1 locomotion	0.2	0.2	0.3	0.6	-0.3	-0.4	-0.4	0.4	-0.3
Short access day 10 total locomotion	0.2	0.2	0.7	-0.1	0.8	-0.2	-0.2	-0.7	0.3
Short access total locomotion	0.0	0.0	0.1	0.0	0.2	-0.2	-0.2	0.2	-0.1
Compulsive drug intake	1.1	1.1	2.1	-0.9	-1.4	-1.1	0.8	1.0	0.9
One hour access (0.3 mA shock)	0.8	0.9	1.9	0.9	1.1	0.5	-1.1	-1.4	-0.5
One hour access (shock baseline)	1.7	2.0	3.4	1.2	1.8	1.2	-1.5	-1.4	-1.2
Number of responses in last shaping day	0.4	0.4	0.9	0.2	0.6	0.9	-0.0	0.8	-0.8
Context. condit. distance diff. score	2.5	3.0	5.4	2.3	1.0	1.2	-2.3	-1.5	-1.7
Locomotion velocity, session 1	1.1	1.2	2.3	-0.8	-1.3	-1.5	0.9	0.3	1.2
Locomotion distance, session 1	0.2	0.3	0.6	0.6	0.1	-0.3	-0.6	-0.8	-0.1
Locomotion velocity, session 2	0.2	0.3	1.0	0.1	0.2	-0.5	-0.0	-1.0	0.5
Locomotion distance, session 2	0.4	0.6	2.9	0.4	0.5	-0.4	-0.3	-1.7	0.4
Locomotion velocity, session 3	0.5	0.6	1.2	1.0	0.3	0.6	-1.1	0.1	-1.0
Locomotion distance, session 3	0.6	0.6	1.2	1.1	-0.0	0.4	-1.0	0.4	-1.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	-0.2	0.6	0.5	0.1	-0.2	-0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	0.1	-0.0	-0.4	-0.5	-0.0
Locomotion velocity, session 7	0.3	0.4	0.6	-0.3	-0.6	-0.8	0.4	-0.5	0.8
Locomotion distance, session 7	0.1	0.1	0.3	-0.4	-0.2	-0.1	0.6	-0.1	0.4
Stereotopy head waving bouts, day 7	2.3	2.6	4.8	2.0	1.0	1.2	-2.2	-0.1	-2.0
Stereotopy head waving duration, day 7	2.2	2.7	5.1	2.1	1.1	1.1	-2.2	-0.4	-2.0
Locomotion velocity, session 8	1.3	1.6	2.4	1.6	1.0	1.1	-1.5	-0.7	-1.4
Locomotion distance, session 8	2.1	3.1	5.1	2.1	1.4	1.0	-2.1	-2.3	-1.3
Degree of sensitization distance	0.6	0.6	1.6	-0.4	1.1	0.7	0.4	-1.3	0.3
Degree of sensitization stereotypy	4.7	5.1	9.4	2.9	1.4	1.8	-3.1	-0.4	-2.8
Condit. Reinf. active minus inactive responses	1.0	1.1	2.1	0.9	1.1	1.5	-0.9	-0.3	-1.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.6	1.2	1.2	1.9	-1.2	0.3	-1.8
Condit. Reinf. active responses	0.3	0.4	0.9	0.2	0.9	1.0	-0.1	0.1	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.8	0.1	-0.5	0.9	-0.0	0.8
Incentive salience index mean	0.5	0.6	1.2	0.5	1.1	1.1	-0.4	0.1	-0.9
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.2	0.4	-0.0	0.3	0.5	-0.1
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.6	0.4	0.4	-0.5	-0.8	-0.4
Time in novel zone, hab. session 1	0.3	0.2	0.7	-0.6	-0.5	-0.1	0.5	0.8	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.3	0.3	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.7	-0.1	0.7	0.8	0.2	-0.9	-0.0
Locomotion velocity, hab. session 1	0.2	0.3	0.9	-0.2	0.8	0.6	0.2	-1.0	0.1
Time in familiar zone, hab. session 2	2.7	2.8	3.8	1.9	1.2	2.0	-1.9	-1.0	-1.9
Time in novel zone, hab. session 2	1.8	1.9	3.4	-1.4	-0.9	-1.9	1.3	-0.1	1.8
Total zone transitions, hab. session 2	1.5	1.9	3.5	1.9	1.0	0.8	-1.8	-1.1	-1.4
Total locomotion distance, hab. session 2	1.7	2.3	5.4	1.0	1.9	1.5	-0.9	-2.3	-0.7
Locomotion velocity, hab. session 2	1.7	2.2	5.2	0.9	2.0	1.5	-0.8	-2.3	-0.7
Novel to familiar place preference ratio	0.7	0.7	1.7	0.3	1.1	1.3	-0.4	0.5	-1.0
Novelty place preference	0.7	0.8	1.8	0.3	1.2	1.3	-0.4	0.3	-1.0
Time in novel zone, NPP test	1.0	1.0	2.3	0.5	1.3	1.5	-0.6	0.2	-1.2
Total zone transitions, NPP test	0.2	0.2	0.8	0.1	-0.1	-0.9	0.0	-0.6	0.5
Total locomotion distance, NPP test	0.8	1.1	4.4	-0.5	0.6	-0.4	0.6	-2.1	1.2
Locomotion velocity, NPP test	0.9	1.3	3.6	-0.8	0.3	-0.7	0.9	-1.9	1.5
Pavlov. Cond. lever latency	0.9	1.1	1.9	-1.0	-1.2	-1.2	1.0	-0.2	1.4
Pavlov. Cond. magazine entry latency	3.0	3.9	5.1	2.3	1.9	1.8	-2.3	-1.6	-2.0
Pavlov. Cond. change in total contacts	1.8	1.9	3.5	1.3	1.3	1.6	-1.3	0.4	-1.9
Pavlov. Cond. index score	2.3	3.0	4.0	1.9	1.8	1.7	-1.9	-0.7	-2.0
Pavlov. Cond. latency score	2.2	2.8	3.9	1.8	1.8	1.7	-1.8	-0.5	-2.0
Pavlov. Cond. lever contacts	0.8	1.0	1.5	1.0	1.1	1.0	-1.0	-0.0	-1.2
Pavlov. Cond. magazine entry number	2.5	3.2	4.5	-2.1	-1.7	-1.6	2.1	0.8	2.0
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.3	-1.1	-0.6	-0.6	1.1	1.1	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.3	1.7	1.5	1.5	-1.7	-0.4	-1.8
Pavlov. Cond. response bias	1.1	1.3	1.6	1.3	1.2	1.1	-1.3	-0.6	-1.3
Bone: apparent density	0.3	0.5	1.6	-0.5	-0.5	-0.5	0.5	1.3	0.2
Bone surface	0.7	1.3	2.5	1.1	0.9	1.2	-1.1	0.6	-1.6
Bone volume	0.5	0.8	1.5	0.8	0.9	1.0	-0.8	0.4	-1.2
Bone: connectivity density	0.5	0.8	1.6	-0.4	-1.2	-1.3	0.4	1.0	0.6
Bone: cortical apparent density	0.6	0.8	1.8	-1.3	-0.1	-0.3	1.4	-0.0	1.0
Bone: cortical area	0.7	1.1	2.3	0.7	1.5	1.2	-0.7	-0.9	-0.9
Bone: cortical porosity	0.4	0.5	1.6	0.4	-0.1	0.4	-0.4	1.3	-0.9
Bone: cortical porosity	0.4	0.4	1.5	0.4	-0.0	0.4	-0.4	1.2	-0.9
Bone: cortical thickness	0.3	0.4	0.8	-0.6	0.0	-0.7	0.7	-0.7	0.9
Bone: cortical thickness	0.1	0.1	0.2	0.1	0.4	0.2	-0.1	-0.3	-0.1
Bone: cortical tissue density	0.6	0.8	1.9	-1.3	-0.2	-0.3	1.4	-0.1	1.0
Bone: elastic displacement	2.5	2.8	4.0	-1.6	-1.7	-2.0	1.7	0.9	1.9
Bone: elastic work	4.0	5.2	8.2	-2.1	-2.5	-2.9	2.1	1.1	2.6
Bone: endosteal estimation	1.7	3.6	5.4	1.8	2.0	2.3	-1.9	-0.2	-2.3
Bone: endosteal perimeter	2.0	4.2	5.9	2.0	2.3	2.4	-2.0	-0.6	-2.4
Bone: final force	0.2	0.4	0.8	-0.3	0.7	0.9	0.2	0.8	-0.5
Bone: final moment	0.3	0.4	1.0	-0.0	0.9	1.0	0.0	0.5	-0.7
Bone: marrow area	1.4	3.0	4.7	1.6	1.8	2.2	-1.7	-0.1	-2.1
Bone: maximum diameter	2.4	4.5	5.9	2.1	2.3	2.4	-2.1	-1.0	-2.4
Bone: maximum force	0.2	0.4	0.8	0.1	0.7	0.9	-0.1	0.8	-0.8
Bone: maximum moment	0.2	0.4	0.8	0.3	0.8	0.9	-0.3	0.5	-0.8
Bone: minimum diameter	1.4	2.6	5.1	1.1	2.3	2.1	-1.1	-0.9	-1.7
Bone: periosteal estimation	1.3	2.6	3.9	1.4	2.0	2.0	-1.5	-0.5	-1.9
Bone: periosteal perimeter	1.6	2.6	3.8	1.5	2.0	1.8	-1.5	-1.0	-1.7
Bone: post-yield work	0.2	0.3	0.6	0.6	0.4	0.5	-0.8	-0.5	-0.5
Bone: stiffness	0.5	0.8	1.8	-0.4	1.0	1.3	0.3	1.0	-0.8
Bone: tissue strength	1.3	1.2	2.8	-0.7	-1.4	-1.7	0.7	0.2	1.3
Bone: trabecular number	1.1	1.8	2.2	-1.3	-1.3	-1.5	1.3	1.4	1.2
Bone: trabecular spacing	0.3	0.4	1.7	0.6	0.3	-0.2	-0.6	-1.3	0.1
Bone: trabecular thickness	0.5	0.6	1.4	0.1	0.8	1.2	-0.0	0.9	-0.9
Bone: trabecular tissue density	0.6	0.9	2.1	-0.7	1.2	1.5	0.7	0.6	-0.5
Breakpoint value in progressive ratio session	0.3	0.3	0.6	-0.3	-0.6	-0.8	0.4	-0.5	0.7
Distance traveled before self-admin	1.1	1.2	2.2	-0.9	-1.1	-1.1	1.2	-0.4	1.5
Distance traveled after self-admin	0.1	0.1	0.3	0.3	-0.4	-0.4	-0.2	-0.5	0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.7	0.2	0.2	0.6	-0.5	0.6
Delta time in open arm before/after self-admin	2.6	2.5	4.6	1.7	1.3	1.7	-1.7	0.1	-2.1
Diff in mean of infusions in LGA sessions	1.0	1.1	4.3	-1.2	-0.3	0.0	0.9	2.1	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4	-0.0	0.4
Active lever presses in extinction session 6	0.4	0.4	0.9	0.9	0.0	-0.1	-0.9	-0.4	-0.6
Delta distance traveled before/after self-admin	3.1	3.3	5.6	1.9	1.6	1.9	-2.1	-0.0	-2.4
Delta ambulatory time before/after self-admin	2.1	2.3	4.0	1.7	1.2	1.5	-1.9	0.1	-2.0
Time in closed arm before self-admin	1.1	1.3	2.6	1.6	0.5	0.4	-1.6	-1.1	-1.0
Time in closed arm after self-admin	0.4	0.4	0.7	-0.7	-0.8	-0.6	0.5	0.6	0.7
Time in open arm before self-admin	5.1	5.5	8.1	-2.9	-2.0	-2.2	2.6	1.1	2.8
Time in open arm after self-admin	0.0	0.1	0.1	-0.0	0.3	0.4	-0.1	0.1	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.6	0.3	0.2	-0.1	-0.2	-0.8	0.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.5	0.8	0.4	-0.8	-0.1	-0.5
Time to tail flick, vehicle, after self-admin	1.5	1.6	3.2	1.5	0.7	1.0	-1.6	0.5	-1.8
Time to tail flick, test, before self-admin	1.9	1.9	3.0	1.4	1.2	1.5	-1.7	-0.2	-1.7
Time to tail flick, test, after self-admin	2.6	2.6	4.6	1.6	1.7	2.1	-1.4	-0.5	-1.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.5	-0.3	0.1	-0.4	0.7	-0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.4	-0.2	-0.3	0.6	-0.4	0.6
Ambulatory time before self-admin	1.2	1.3	2.0	-1.0	-1.3	-1.1	1.4	0.1	1.4
Ambulatory time after self-admin	0.2	0.2	0.5	0.7	-0.2	0.1	-0.6	-0.0	-0.4
Total heroin consumption	0.7	0.9	2.7	1.0	0.8	0.4	-0.9	-1.6	-0.4
Area under the delay curve	0.3	0.3	0.9	-0.7	-0.0	-0.1	0.6	1.0	0.2
Delay disc. indifference point, 0s delay	0.7	0.7	1.7	0.7	1.3	0.7	-0.8	-0.8	-0.6
Delay disc. indifference point, 16s delay	0.3	0.3	1.6	-0.5	-0.0	0.3	0.3	1.3	-0.1
Delay disc. indifference point, 2s delay	0.9	1.0	1.8	0.7	1.4	1.2	-0.8	-0.0	-1.2
Delay disc. indifference point, 24s delay	0.8	0.8	1.5	-1.2	-0.4	-0.4	1.0	1.0	0.8
Delay disc. indifference point, 4s delay	1.3	1.3	2.6	0.9	1.6	1.3	-1.0	-0.7	-1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.6	-0.2	-0.3	0.6	0.7	0.3
Delay discount exponential model param	0.4	0.4	0.8	0.8	0.1	0.3	-0.7	-0.9	-0.4
Delay discount hyperbolic model param	0.2	0.2	0.5	0.6	-0.1	0.0	-0.5	-0.7	-0.1
Fecal boli incidents, locomotor time 1	1.7	1.8	5.0	-1.3	-1.2	-0.9	1.3	2.2	0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.4	-0.2	0.2	-0.2	-0.7	-0.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.9	0.8	0.5	0.8	-0.6	0.0	-1.0
Bouts of movement, locomotor time 1	0.4	0.5	1.5	0.2	0.5	0.6	-0.2	1.2	-0.7
Total resting periods, locomotor time 1	0.3	0.3	1.8	-0.2	-0.1	-0.0	0.3	1.4	-0.2
Rest time, locomotor task time 1	0.3	0.3	1.2	0.3	-0.2	0.5	-0.3	1.1	-0.7
Distance moved, locomotor task time 1	0.2	0.2	0.8	-0.1	0.5	-0.0	-0.1	-0.9	0.3
Vertical activity count, locomotor time 1	0.2	0.2	0.7	-0.0	0.9	0.3	-0.1	-0.4	0.0
Time >=10cm from walls, locomotor time 2	3.4	3.6	5.1	2.0	1.9	2.3	-1.8	-1.0	-2.1
Bouts of movement, locomotor time 2	1.1	1.1	2.8	0.5	1.5	1.7	-0.4	0.5	-1.2
Total resting periods, locomotor time 2	0.5	0.6	1.4	0.1	1.1	1.2	-0.0	0.7	-0.7
Rest time, locomotor task time 2	2.1	2.4	3.2	-1.8	-1.4	-1.5	1.6	1.1	1.8
Distance moved, locomotor task time 2	2.8	3.3	3.8	1.9	1.9	1.7	-2.0	-1.6	-1.8
Vertical activity count, locomotor time 2	1.0	1.1	2.1	0.9	1.5	1.4	-0.8	-0.5	-1.1
Weight adjusted by age	0.9	1.0	1.5	1.2	0.8	1.0	-0.9	-1.2	-0.9
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	3.0	-1.7	-1.7	-1.7	1.6	1.7	1.5
Locomotion in novel chamber	1.0	1.3	2.6	-0.8	-1.3	-1.6	0.8	-0.2	1.4
Locomotion in novel chamber post-restriction	0.3	0.3	1.0	0.8	0.0	-0.0	-1.0	0.0	-0.7
Progressive ratio	0.1	0.1	0.5	-0.2	-0.5	-0.7	-0.0	0.1	0.3
Food seeking constrained by brief footshock	2.0	2.5	2.8	1.5	1.6	1.7	-1.7	-1.3	-1.6
Seeking ratio, punishment vs. effort	1.5	1.8	2.9	1.2	1.6	1.7	-1.0	-1.2	-1.3
Run reversals in cocaine runway, females	1.1	1.1	4.1	0.6	1.1	0.8	-0.4	-2.0	-0.2
Run reversals in cocaine runway, males	0.5	0.5	1.6	-0.7	-0.5	-0.5	0.6	1.2	0.4
Latency to leave start box in cocaine runway	0.7	0.8	1.5	-1.0	-0.7	-0.6	1.0	1.2	0.7
Latency to leave start box in cocaine runway, F	0.3	0.3	0.9	-0.8	-0.2	0.0	0.6	0.9	0.3
Latency to leave start box in cocaine runway, M	1.2	1.1	1.5	-0.8	-1.2	-1.1	1.1	1.2	0.9
Cd content in liver	0.4	0.4	0.7	-0.8	-0.5	-0.4	0.8	0.8	0.5
Co content in liver	3.2	3.8	6.2	1.8	2.0	2.5	-1.8	-0.1	-2.5
Cu content in liver	1.5	1.8	3.1	1.3	1.3	1.8	-1.2	-0.0	-1.7
Fe content in liver	0.3	0.3	1.1	-0.1	0.2	0.5	0.0	1.1	-0.6
K content in liver	0.5	0.5	0.9	-0.9	0.4	-0.4	0.9	-0.3	0.8
Mg content in liver	0.1	0.1	0.2	-0.0	0.5	-0.1	0.1	-0.5	0.1
Mn content in liver	2.5	2.9	3.6	-1.8	-1.7	-1.9	1.8	1.0	1.9
Na content in liver	0.2	0.2	0.4	0.4	0.5	0.2	-0.5	0.5	-0.7
Rb content in liver	0.7	0.9	1.8	0.8	1.0	1.0	-0.8	0.6	-1.3
Se content in liver	3.8	4.6	6.2	-2.5	-1.9	-1.8	2.4	2.3	1.9
Sr content in liver	0.5	0.5	1.0	0.1	-0.8	-1.0	-0.1	-0.8	0.7
Zn content in liver	2.0	2.1	3.4	1.8	1.2	0.8	-1.8	-1.7	-1.1