| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | mRNA stability | ENSRNOG00000019555 | 0.0550 | 0.0350 | 3.0e-05 | 0.027 | 0.027 | 0.023 | 0.023 | 4.4e-04 | 4.6e-04 | 1.3e-03 | 1.1e-03 |
| 2 | Brain | gene expression | ENSRNOG00000019555 | 0.0670 | 0.0420 | 6.2e-05 | 0.024 | 0.044 | 0.027 | 0.035 | 2.6e-03 | 5.8e-05 | 1.4e-03 | 2.9e-04 |
| 3 | Brain | mRNA stability | ENSRNOG00000019555 | 0.0704 | 0.0408 | 3.6e-05 | 0.041 | 0.052 | 0.045 | 0.050 | 9.4e-05 | 1.2e-05 | 4.9e-05 | 1.8e-05 |
| 4 | IL | gene expression | ENSRNOG00000019555 | 0.2410 | 0.1230 | 2.1e-03 | 0.019 | 0.048 | 0.018 | 0.030 | 1.1e-01 | 2.7e-02 | 1.2e-01 | 6.6e-02 |
| 5 | NAcc | gene expression | ENSRNOG00000019555 | 0.0660 | 0.0410 | 1.2e-04 | 0.052 | 0.046 | 0.041 | 0.051 | 9.2e-05 | 2.2e-04 | 4.7e-04 | 1.2e-04 |
| 6 | OFC | gene expression | ENSRNOG00000019555 | 0.3197 | 0.1631 | 1.2e-03 | 0.088 | 0.050 | 0.045 | 0.085 | 4.2e-03 | 2.6e-02 | 3.2e-02 | 4.8e-03 |
| 7 | PL | gene expression | ENSRNOG00000019555 | 0.1082 | 0.0672 | 1.6e-05 | 0.048 | 0.050 | 0.050 | 0.013 | 1.4e-04 | 1.1e-04 | 1.1e-04 | 3.3e-02 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|---|---|---|
| Condit. Reinf. lever presses | 12.4 | 17.0 | 33.4 | -5.8 | 1.9 | -4.4 | 4.6 | 5.5 | 2.8 | -1.7 |
| Pavlov. Cond. lever contacts | 12.4 | 17.3 | 34.4 | -5.9 | 1.5 | -4.5 | 4.7 | 5.7 | 2.6 | -1.9 |
| Pavlov. Cond. lever latency | 12.0 | 16.4 | 32.4 | 5.7 | -1.4 | 4.5 | -4.7 | -5.4 | -2.5 | 1.9 |
| Pavlov. Cond. response bias | 11.8 | 16.3 | 32.1 | -5.7 | 1.1 | -4.4 | 4.6 | 5.6 | 2.3 | -1.8 |
| Condit. Reinf. lever reinforcers received | 10.7 | 15.1 | 26.4 | -5.1 | 2.7 | -4.1 | 4.3 | 4.9 | 3.1 | -1.6 |
| Condit. Reinf. active responses | 10.5 | 14.6 | 24.2 | -4.9 | 2.8 | -4.1 | 4.3 | 4.7 | 3.1 | -1.7 |
| Pavlov. Cond. change in total contacts | 9.7 | 13.5 | 27.6 | -5.2 | 0.9 | -4.0 | 4.1 | 5.2 | 1.8 | -1.8 |
| Pavlov. Cond. index score | 8.4 | 11.0 | 21.3 | -4.6 | 0.7 | -3.7 | 3.8 | 4.6 | 1.9 | -1.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 8.2 | 10.6 | 19.7 | -4.4 | 0.7 | -3.7 | 3.8 | 4.4 | 2.0 | -1.6 |
| Condit. Reinf. active minus inactive responses | 7.7 | 9.5 | 16.3 | -4.0 | 2.0 | -3.3 | 3.4 | 3.8 | 2.4 | -1.7 |
| Mean time between licks in bursts | 7.5 | 10.5 | 14.4 | -3.3 | 3.4 | -3.7 | 3.8 | 3.0 | 3.2 | -1.8 |
| Pavlov. Cond. latency score | 7.2 | 9.2 | 18.5 | -4.3 | 0.3 | -3.4 | 3.5 | 4.2 | 1.7 | -1.3 |
| Condit. Reinf. inactive responses | 6.7 | 8.4 | 13.9 | -3.7 | 2.5 | -3.1 | 3.2 | 3.4 | 2.5 | -0.8 |
| Tail length | 6.5 | 19.6 | 24.8 | -3.1 | 4.9 | -5.0 | 5.0 | 3.9 | 4.8 | -3.9 |
| Bone: elastic work | 3.9 | 5.0 | 7.2 | 2.2 | -2.7 | 2.4 | -2.5 | -2.2 | -1.8 | 1.8 |
| Length with tail | 3.8 | 13.9 | 21.2 | -2.3 | 4.6 | -4.1 | 4.1 | 3.1 | 4.1 | -3.2 |
| Pavlov. Cond. magazine entry number | 3.3 | 4.0 | 9.0 | 2.9 | 0.6 | 2.1 | -2.2 | -3.0 | -0.6 | 0.7 |
| Time in open arm before self-admin | 3.2 | 3.4 | 7.4 | 2.7 | -0.9 | 1.8 | -2.0 | -2.7 | -0.3 | 1.0 |
| Std. dev. time between licks in bursts | 3.1 | 3.7 | 5.9 | -1.5 | 2.4 | -2.2 | 2.2 | 1.4 | 2.4 | -1.0 |
| Saline control response | 3.0 | 4.0 | 6.9 | -2.6 | 2.1 | -2.0 | 2.1 | 2.2 | 1.4 | -1.1 |
| Co content in liver | 2.9 | 3.4 | 5.5 | -2.1 | 2.3 | -1.8 | 1.9 | 1.9 | 1.4 | -1.1 |
| Se content in liver | 2.9 | 3.5 | 5.2 | 2.3 | -0.8 | 2.2 | -2.3 | -2.2 | -1.4 | 1.3 |
| Time to tail flick, test, after self-admin | 2.7 | 2.8 | 4.3 | -1.3 | 2.1 | -1.9 | 1.9 | 1.0 | 1.9 | -1.4 |
| Distance moved, locomotor task time 2 | 2.7 | 3.1 | 5.2 | -2.3 | 1.1 | -2.0 | 2.0 | 2.2 | 1.4 | -0.9 |
| Reaction time premature initiation rate | 2.6 | 3.6 | 6.9 | -1.6 | 1.5 | -2.3 | 2.2 | 1.5 | 2.6 | -0.8 |
| Time >=10cm from walls, locomotor time 2 | 2.5 | 2.7 | 3.5 | -1.7 | 1.8 | -1.8 | 1.9 | 1.6 | 0.8 | -1.6 |
| Delay discounting time to switch 0 sec | 2.4 | 3.6 | 6.7 | 2.6 | -0.6 | 2.2 | -2.2 | -2.4 | -1.4 | 0.8 |
| Degree of sensitization stereotypy | 2.4 | 2.6 | 7.1 | -2.4 | 0.1 | -1.4 | 1.6 | 2.7 | 0.0 | -0.7 |
| Mn content in liver | 2.4 | 2.8 | 3.7 | 1.7 | -1.5 | 1.9 | -1.9 | -1.8 | -1.7 | 1.0 |
| Pavlov. Cond. magazine entry latency | 2.3 | 2.9 | 5.1 | -2.1 | 0.9 | -2.0 | 2.0 | 2.3 | 1.3 | -0.9 |
| Bone: elastic displacement | 2.3 | 2.6 | 3.5 | 1.7 | -1.7 | 1.8 | -1.9 | -1.5 | -1.5 | 1.1 |
| Bone: maximum diameter | 2.2 | 4.0 | 5.9 | -2.4 | 1.9 | -2.2 | 2.2 | 2.3 | 1.7 | -1.0 |
| Time in familiar zone, hab. session 2 | 2.1 | 2.2 | 3.8 | -1.3 | 1.3 | -1.6 | 1.7 | 1.3 | 0.9 | -2.0 |
| Delta time in open arm before/after self-admin | 2.1 | 2.0 | 4.3 | -2.1 | 1.0 | -1.2 | 1.3 | 1.9 | 1.0 | -0.8 |
| Delta distance traveled before/after self-admin | 2.1 | 2.2 | 5.7 | -1.6 | 1.2 | -1.1 | 1.2 | 1.8 | -0.4 | -2.4 |
| Run reversals in cocaine runway, females | 2.1 | 2.0 | 6.9 | -0.5 | 1.0 | -1.8 | 1.6 | 0.4 | 2.6 | -0.4 |
| Light reinforcement 1 | 2.0 | 3.7 | 7.8 | 2.7 | -1.7 | 1.6 | -1.8 | -2.8 | -0.8 | 0.8 |
| One hour access (shock baseline) | 2.0 | 2.3 | 5.1 | -2.2 | 1.0 | -1.5 | 1.5 | 2.0 | 1.2 | 0.2 |
| Pavlov. Cond. index score | 2.0 | 2.5 | 4.7 | -2.2 | 1.0 | -1.6 | 1.7 | 2.2 | 1.3 | -0.3 |
| Pavlov. Cond. magazine entry number | 2.0 | 2.5 | 5.3 | 2.2 | -0.7 | 1.6 | -1.7 | -2.3 | -1.1 | 0.4 |
| Bone: tissue strength | 2.0 | 1.9 | 4.2 | 1.0 | -2.1 | 1.4 | -1.4 | -0.7 | -1.7 | 0.9 |
| Seeking ratio, punishment vs. effort | 2.0 | 2.5 | 3.3 | -1.2 | 1.7 | -1.8 | 1.8 | 1.6 | 1.8 | -0.9 |
| Number of licking bursts | 1.9 | 2.2 | 6.0 | 2.5 | -0.3 | 1.3 | -1.5 | -2.1 | -0.1 | 0.9 |
| Delay discounting water rate 18 sec | 1.9 | 2.5 | 3.7 | -1.9 | 0.0 | -1.9 | 1.9 | 1.7 | 1.2 | -1.5 |
| Baseline Anxiety | 1.9 | 2.0 | 3.4 | -1.8 | 1.2 | -1.5 | 1.6 | 1.6 | 1.2 | -0.5 |
| Incentive Sensitization - Responses | 1.9 | 1.9 | 4.2 | -2.0 | 1.3 | -1.1 | 1.2 | 1.8 | 1.0 | 0.4 |
| Short access day 1 total infusions | 1.9 | 2.0 | 5.2 | -2.3 | 0.9 | -1.3 | 1.4 | 1.9 | 0.8 | -0.1 |
| Total locomotion distance, hab. session 2 | 1.9 | 2.5 | 4.1 | -0.8 | 1.7 | -2.0 | 1.9 | 0.9 | 1.5 | -1.7 |
| Locomotion velocity, hab. session 2 | 1.9 | 2.6 | 4.2 | -0.7 | 1.8 | -2.0 | 1.9 | 0.9 | 1.7 | -1.7 |
| Pavlov. Cond. latency score | 1.9 | 2.4 | 4.6 | -2.1 | 1.1 | -1.5 | 1.6 | 2.1 | 1.2 | -0.2 |
| Bone: endosteal perimeter | 1.9 | 3.9 | 4.8 | -2.2 | 2.0 | -2.1 | 2.2 | 2.2 | 2.1 | -0.7 |
| Bone: minimum diameter | 1.9 | 3.6 | 6.0 | -1.4 | 2.4 | -2.1 | 2.0 | 1.5 | 2.3 | -1.0 |
| Rest time, locomotor task time 2 | 1.9 | 2.2 | 4.2 | 2.0 | -0.8 | 1.5 | -1.6 | -1.9 | -1.2 | 0.9 |
| Food seeking constrained by brief footshock | 1.8 | 2.2 | 3.3 | -1.2 | 1.2 | -1.8 | 1.8 | 1.5 | 1.5 | -1.1 |
| Mean num. licks in bursts | 1.7 | 2.0 | 4.6 | -2.2 | 0.5 | -1.3 | 1.5 | 2.1 | 0.3 | -0.8 |
| Delay discounting total patch changes 12 sec | 1.7 | 2.3 | 3.2 | -1.7 | 1.4 | -1.8 | 1.8 | 1.3 | 1.7 | -0.2 |
| Delay discounting total patch changes 24 sec | 1.7 | 2.1 | 3.1 | -1.7 | 1.3 | -1.7 | 1.7 | 1.0 | 1.8 | -0.4 |
| Pavlov. Cond. magazine entry latency | 1.7 | 2.0 | 4.0 | -1.9 | -1.1 | -1.5 | 1.5 | 2.0 | 0.4 | -0.4 |
| Cocaine induced anxiety | 1.7 | 2.0 | 4.3 | 2.1 | 0.2 | 1.6 | -1.6 | -1.9 | -0.8 | 0.4 |
| Seeking ratio, delayed vs. immediate footshock | 1.7 | 2.0 | 3.2 | 1.5 | -1.3 | 1.8 | -1.8 | -1.4 | -0.9 | 0.9 |
| Zn content in liver | 1.7 | 1.9 | 4.9 | -2.2 | -0.3 | -1.4 | 1.4 | 1.8 | 0.9 | 0.4 |
| Locomotor testing rearing | 1.6 | 2.5 | 3.5 | -1.5 | 1.4 | -1.9 | 1.8 | 1.5 | 1.7 | -0.9 |
| Short access day 10 total infusions | 1.6 | 1.8 | 3.9 | -2.0 | 0.9 | -1.2 | 1.3 | 2.0 | 0.9 | 0.2 |
| Condit. Reinf. active-inactive response ratio | 1.6 | 1.7 | 3.5 | -1.1 | 1.9 | -1.3 | 1.3 | 1.0 | 1.3 | -1.1 |
| Bone: endosteal estimation | 1.6 | 3.5 | 4.7 | -1.7 | 2.1 | -2.0 | 2.0 | 1.7 | 2.2 | -1.0 |
| Bone: periosteal perimeter | 1.6 | 2.6 | 3.8 | -1.9 | 1.5 | -1.8 | 1.8 | 1.9 | 1.6 | -0.4 |
| Delay disc. indifference point, 4s delay | 1.6 | 1.7 | 2.4 | -1.2 | 1.5 | -1.4 | 1.4 | 1.5 | 1.4 | -0.4 |
| Cu content in liver | 1.6 | 1.9 | 2.8 | -1.4 | 1.7 | -1.4 | 1.4 | 1.3 | 1.5 | -0.8 |
| Liver weight, right | 1.5 | 2.6 | 8.7 | 0.6 | 3.0 | -0.9 | 0.8 | -0.6 | 2.2 | -1.4 |
| Light reinforcement 2 | 1.5 | 2.0 | 6.9 | 1.3 | -2.6 | 1.0 | -1.1 | -1.1 | -1.0 | 0.7 |
| Social time | 1.5 | 2.0 | 2.6 | 1.6 | -0.7 | 1.5 | -1.6 | -1.4 | -1.5 | 1.4 |
| Incentive Sensitization - Breakpoint | 1.5 | 1.5 | 3.7 | -1.9 | 1.0 | -1.0 | 1.0 | 1.7 | 0.8 | 0.5 |
| One hour access (0.3 mA shock) | 1.5 | 1.8 | 5.8 | -2.4 | 0.1 | -1.0 | 1.0 | 1.7 | 0.9 | 0.8 |
| Time in novel zone, hab. session 2 | 1.5 | 1.5 | 3.3 | 0.7 | -1.6 | 1.2 | -1.3 | -0.7 | -0.8 | 1.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.5 | 1.9 | 3.7 | -1.9 | 0.8 | -1.4 | 1.5 | 1.9 | 1.1 | -0.2 |
| Time to tail flick, test, before self-admin | 1.5 | 1.4 | 2.8 | -1.2 | 1.0 | -1.2 | 1.3 | 1.7 | 0.9 | -0.9 |
| Bouts of movement, locomotor time 2 | 1.5 | 1.6 | 5.5 | -0.8 | 2.4 | -1.2 | 1.2 | 0.4 | 1.3 | 0.6 |
| Locomotor testing distance | 1.4 | 2.4 | 3.8 | -1.8 | 0.6 | -1.9 | 1.9 | 1.9 | 1.2 | -0.6 |
| Total sessions with >9 infusions | 1.4 | 1.6 | 4.6 | -2.1 | -0.6 | -1.0 | 1.1 | 2.0 | -0.1 | 0.4 |
| Bone: marrow area | 1.4 | 3.0 | 4.5 | -1.5 | 2.1 | -1.8 | 1.9 | 1.5 | 2.1 | -0.9 |
| Bone: periosteal estimation | 1.4 | 2.9 | 3.7 | -1.8 | 1.9 | -1.8 | 1.8 | 1.7 | 1.9 | -0.5 |
| Delta ambulatory time before/after self-admin | 1.4 | 1.5 | 4.6 | -1.3 | 0.6 | -0.6 | 0.8 | 1.5 | -0.8 | -2.1 |
| Vertical activity count, locomotor time 2 | 1.4 | 1.5 | 2.6 | -1.3 | 1.6 | -1.3 | 1.3 | 1.1 | 1.3 | -0.3 |
| Lifetime Intake | 1.3 | 1.4 | 4.4 | -2.1 | 0.6 | -0.9 | 1.0 | 1.7 | 0.5 | 0.3 |
| Context. condit. distance diff. score | 1.3 | 1.6 | 3.0 | -1.7 | -0.2 | -1.2 | 1.4 | 1.6 | -0.3 | -1.5 |
| Locomotion velocity, session 1 | 1.3 | 1.3 | 2.9 | 0.7 | -1.7 | 1.2 | -1.2 | -0.9 | -1.2 | 0.9 |
| Stereotopy head waving duration, day 7 | 1.3 | 1.6 | 4.8 | -2.0 | -0.1 | -1.1 | 1.2 | 2.2 | 0.3 | -0.1 |
| Locomotion distance, session 8 | 1.3 | 1.9 | 3.9 | -2.0 | -0.3 | -1.5 | 1.6 | 1.9 | 0.1 | -0.8 |
| Bone: trabecular tissue density | 1.3 | 1.9 | 8.8 | 0.2 | 3.0 | -0.8 | 0.7 | -0.1 | 1.5 | -0.9 |
| Left kidney weight | 1.2 | 3.5 | 7.1 | -1.4 | 1.0 | -2.4 | 2.3 | 1.4 | 2.7 | -1.2 |
| Food consumed during 24 hour testing period | 1.2 | 1.4 | 4.4 | -2.0 | -0.3 | -0.8 | 1.0 | 2.1 | 0.0 | -0.1 |
| Delay discounting water rate 0 sec | 1.2 | 2.0 | 4.4 | -2.1 | 0.4 | -1.5 | 1.6 | 1.9 | 0.6 | -0.6 |
| Condit. Reinf. active-inactive response ratio | 1.2 | 1.3 | 2.6 | -1.6 | 0.3 | -1.1 | 1.2 | 1.6 | 0.8 | -0.7 |
| Intermittent access day 1 total infusions | 1.2 | 1.3 | 3.2 | -1.8 | 1.2 | -0.9 | 1.1 | 1.6 | 0.6 | 0.0 |
| Intermittent access terminal intake (last 3 days) | 1.2 | 1.3 | 3.8 | -1.9 | 0.6 | -0.9 | 0.9 | 1.7 | 0.5 | 0.7 |
| Short access total infusions | 1.2 | 1.3 | 3.3 | -1.8 | 0.6 | -1.1 | 1.2 | 1.6 | 0.7 | -0.1 |
| Stereotopy head waving bouts, day 7 | 1.2 | 1.3 | 3.8 | -1.9 | 0.0 | -0.9 | 1.1 | 1.9 | -0.1 | -0.2 |
| Pavlov. Cond. change in total contacts | 1.2 | 1.3 | 2.2 | -1.5 | 1.3 | -1.0 | 1.1 | 1.4 | 0.8 | -0.4 |
| Bone: trabecular number | 1.2 | 1.9 | 2.7 | 1.2 | -1.3 | 1.7 | -1.7 | -1.2 | -1.4 | 1.1 |
| Fecal boli incidents, locomotor time 1 | 1.2 | 1.3 | 3.9 | -0.3 | -0.3 | 1.6 | -1.4 | -0.5 | -0.5 | 2.0 |
| BMI without tail | 1.1 | 2.3 | 6.8 | -0.8 | 0.3 | -1.9 | 1.7 | 0.7 | 2.6 | -1.0 |
| Indifference point 0 sec | 1.1 | 1.8 | 5.1 | -2.3 | 0.3 | -1.4 | 1.6 | 1.6 | 0.8 | -0.1 |
| Reaction time premature initiations | 1.1 | 1.5 | 2.3 | -1.4 | 0.8 | -1.5 | 1.5 | 1.2 | 1.4 | -0.2 |
| Intermittent access day 15 total infusions | 1.1 | 1.2 | 4.1 | -2.0 | 0.3 | -0.7 | 0.8 | 1.6 | 0.2 | 0.9 |
| Progressive ratio test 2 active lever presses | 1.1 | 1.2 | 2.9 | -1.7 | 1.0 | -0.6 | 0.7 | 1.5 | 0.6 | 0.9 |
| Progressive ratio test 2 breakpoint | 1.1 | 1.2 | 3.0 | -1.7 | 1.1 | -0.7 | 0.8 | 1.5 | 0.7 | 0.7 |
| Compulsive drug intake | 1.1 | 1.1 | 1.7 | 0.6 | -1.1 | 1.3 | -1.2 | -1.2 | -1.0 | 0.5 |
| Degree of sensitization distance | 1.1 | 1.1 | 2.8 | -0.1 | 1.6 | -1.1 | 1.0 | -0.0 | 1.7 | -0.7 |
| Condit. Reinf. active minus inactive responses | 1.1 | 1.2 | 2.1 | -0.9 | 1.5 | -1.1 | 1.1 | 0.8 | 1.0 | -1.1 |
| Delay disc. indifference point, 2s delay | 1.1 | 1.2 | 2.3 | -1.3 | 1.3 | -0.9 | 0.9 | 1.5 | 1.1 | -0.2 |
| Delay discounting total patch changes 18 sec | 1.0 | 1.4 | 3.8 | -2.0 | 0.6 | -1.1 | 1.2 | 1.1 | 1.1 | 0.5 |
| Pavlov. Cond. intertrial magazine entries | 1.0 | 1.3 | 3.2 | -0.6 | 1.8 | -1.0 | 1.0 | 0.7 | 1.6 | -0.7 |
| Intermittent access total infusions | 1.0 | 1.1 | 3.5 | -1.9 | 0.7 | -0.7 | 0.8 | 1.5 | 0.5 | 0.3 |
| Total zone transitions, hab. session 2 | 1.0 | 1.3 | 3.4 | -1.6 | -0.4 | -0.9 | 1.0 | 1.8 | -0.6 | -0.7 |
| Ambulatory time after self-admin | 1.0 | 1.1 | 3.5 | 0.5 | -0.6 | 0.3 | -0.2 | -0.0 | -1.9 | -1.8 |
| Total resting periods, locomotor time 2 | 1.0 | 1.0 | 4.0 | -0.4 | 2.0 | -0.7 | 0.7 | -0.0 | 1.1 | 1.0 |
| Locomotion in novel chamber | 1.0 | 1.3 | 3.1 | 0.3 | -1.7 | 1.3 | -1.2 | -0.2 | -1.2 | 1.1 |
| Latency to leave start box in cocaine runway, M | 1.0 | 1.0 | 1.4 | 0.9 | -1.0 | 1.2 | -1.2 | -1.0 | -0.7 | 0.8 |
| Body weight | 0.9 | 3.8 | 9.1 | -0.9 | 1.8 | -2.4 | 2.2 | 0.9 | 3.0 | -1.4 |
| Retroperitoneal fat weight | 0.9 | 3.1 | 12.3 | 1.6 | 1.7 | -1.2 | 0.8 | -1.2 | 3.5 | -0.7 |
| Delay discounting total patch changes 0 sec | 0.9 | 1.5 | 4.3 | -2.1 | 0.2 | -1.3 | 1.4 | 1.4 | 0.8 | -0.0 |
| Std. dev. reaction times | 0.9 | 1.2 | 3.3 | -0.8 | 1.8 | -1.0 | 0.9 | 0.6 | 1.5 | -0.2 |
| Locomotion velocity, session 8 | 0.9 | 1.1 | 2.0 | -1.4 | 0.4 | -1.0 | 1.1 | 1.4 | -0.1 | -1.2 |
| Time in novel zone, NPP test | 0.9 | 0.9 | 3.4 | -0.7 | 1.9 | -0.7 | 0.8 | 0.9 | -0.0 | -0.6 |
| Pavlov. Cond. lever contacts | 0.9 | 1.0 | 2.1 | -1.5 | 0.8 | -0.9 | 1.0 | 1.2 | 1.1 | 0.1 |
| Pavlov. Cond. response bias | 0.9 | 1.2 | 1.9 | -1.4 | 0.7 | -1.1 | 1.2 | 1.4 | 1.0 | -0.3 |
| Distance traveled after self-admin | 0.9 | 1.0 | 3.3 | 0.6 | -0.9 | 0.3 | -0.3 | -0.0 | -1.5 | -1.8 |
| Delta time in closed arm before/after self-admin | 0.9 | 0.8 | 2.4 | 0.8 | 1.2 | -0.6 | 0.4 | -1.0 | 1.5 | -0.1 |
| Time in closed arm before self-admin | 0.9 | 1.0 | 2.3 | -1.3 | -0.8 | -0.3 | 0.4 | 1.4 | -1.5 | -0.1 |
| Time in closed arm after self-admin | 0.9 | 0.9 | 1.5 | 0.8 | -0.3 | 0.9 | -0.9 | -1.0 | -1.2 | 1.2 |
| Ambulatory time before self-admin | 0.9 | 1.0 | 2.1 | 1.4 | -0.8 | 0.8 | -0.9 | -1.3 | -0.6 | 0.4 |
| Delay disc. indifference point, 24s delay | 0.9 | 0.9 | 2.0 | 1.4 | 0.5 | 0.9 | -0.9 | -1.4 | -0.5 | -0.7 |
| Change in fecal boli incidents, locomotor task | 0.9 | 0.8 | 3.7 | 1.1 | 0.0 | -0.3 | 0.3 | -0.9 | 0.0 | -1.9 |
| Weight adjusted by age | 0.9 | 1.0 | 1.9 | -0.7 | 0.6 | -1.3 | 1.3 | 0.9 | 1.4 | -0.4 |
| Right kidney weight | 0.8 | 2.3 | 4.4 | -1.1 | 1.1 | -1.9 | 1.8 | 0.9 | 2.1 | -1.3 |
| Conditioned reinforcement - actives | 0.8 | 0.8 | 2.8 | -1.7 | -0.3 | 0.0 | 0.1 | 1.2 | -0.2 | 1.2 |
| Intermittent access intake escalation | 0.8 | 0.7 | 1.7 | -1.1 | -1.2 | -0.1 | 0.1 | 0.9 | -0.1 | 1.3 |
| Pavlov. Cond. lever latency | 0.8 | 1.0 | 2.3 | 1.5 | -0.9 | 0.8 | -0.9 | -1.4 | -0.7 | -0.2 |
| Bone: connectivity density | 0.8 | 1.2 | 2.9 | 0.4 | -1.7 | 1.2 | -1.2 | -0.6 | -1.0 | 1.1 |
| Bone: cortical area | 0.8 | 1.2 | 1.6 | -1.2 | 1.3 | -1.2 | 1.2 | 1.1 | 1.0 | -0.3 |
| Liver weight, left | 0.7 | 1.2 | 4.8 | 0.5 | 2.2 | -0.2 | 0.2 | -0.8 | 1.5 | -0.3 |
| Intraocular pressure | 0.7 | 1.0 | 2.7 | 0.2 | -1.6 | 1.3 | -1.2 | -0.5 | -0.9 | 0.5 |
| Indifference point AUC | 0.7 | 0.8 | 1.5 | -0.8 | 0.9 | -1.1 | 1.1 | 0.6 | 1.2 | -0.1 |
| Delay discounting water rate 12 sec | 0.7 | 1.1 | 2.9 | -1.7 | -1.3 | -1.0 | 1.0 | 1.1 | 0.1 | -0.1 |
| Reaction time mean minus median | 0.7 | 0.9 | 1.4 | -1.2 | 0.8 | -1.0 | 1.0 | 1.1 | 0.9 | 0.0 |
| Reaction time num false alarms | 0.7 | 0.9 | 2.4 | 1.3 | 0.7 | 0.8 | -0.9 | -1.5 | 0.2 | 0.6 |
| Cocaine response after cond. corrected | 0.7 | 0.7 | 2.3 | 1.5 | -0.2 | 0.5 | -0.7 | -1.3 | 0.5 | 0.2 |
| Conditioned locomotion | 0.7 | 0.8 | 2.1 | -1.4 | -0.9 | -0.1 | 0.2 | 1.4 | -0.7 | 0.6 |
| Intermittent access day 15 total locomotion | 0.7 | 0.8 | 2.3 | -1.3 | -0.6 | 0.0 | 0.1 | 1.1 | -0.3 | 1.5 |
| Total locomotion distance, hab. session 1 | 0.7 | 0.9 | 1.9 | 0.2 | 1.4 | -1.0 | 0.8 | -0.3 | 1.3 | -1.1 |
| Novel to familiar place preference ratio | 0.7 | 0.7 | 3.2 | -0.5 | 1.8 | -0.5 | 0.6 | 0.7 | -0.0 | -0.4 |
| Novelty place preference | 0.7 | 0.7 | 3.1 | -0.5 | 1.8 | -0.6 | 0.7 | 0.8 | -0.0 | -0.5 |
| Diff in mean of infusions in LGA sessions | 0.7 | 0.7 | 1.4 | 1.2 | 1.0 | 0.7 | -0.8 | -0.6 | -0.1 | 1.0 |
| Active lever presses in extinction session 6 | 0.7 | 0.6 | 1.9 | -0.7 | -1.1 | 0.2 | -0.1 | 0.8 | -1.4 | 0.4 |
| Time to tail flick, vehicle, after self-admin | 0.7 | 0.7 | 2.5 | -1.3 | 0.2 | -0.4 | 0.6 | 1.6 | -0.4 | -0.3 |
| Delay disc. indifference point, 0s delay | 0.7 | 0.7 | 1.4 | -1.2 | 0.6 | -0.9 | 0.9 | 1.0 | 0.5 | 0.6 |
| Latency to leave start box in cocaine runway | 0.7 | 0.8 | 2.1 | 1.3 | 0.0 | 0.6 | -0.7 | -1.4 | 0.5 | 0.8 |
| Reaction time num false alarms AUC | 0.6 | 0.9 | 2.0 | 1.0 | 0.4 | 1.0 | -1.1 | -1.4 | -0.1 | 1.0 |
| Median of all reaction times | 0.6 | 0.9 | 2.0 | 1.4 | 0.9 | 0.8 | -0.8 | -1.4 | 0.0 | 0.0 |
| Social responses | 0.6 | 0.8 | 1.9 | -0.3 | 1.4 | -0.9 | 0.7 | 0.1 | 1.4 | 0.7 |
| Cocaine response after cond. not corrected | 0.6 | 0.6 | 1.1 | 1.1 | -0.9 | 0.7 | -0.8 | -1.1 | 0.1 | 0.4 |
| Intermittent access intake day 1-15 change | 0.6 | 0.6 | 1.4 | -1.0 | -1.2 | -0.3 | 0.3 | 0.9 | 0.0 | 1.0 |
| Incentive salience index mean | 0.6 | 0.8 | 1.8 | -0.9 | 1.3 | -0.8 | 0.8 | 0.8 | 0.9 | -0.2 |
| Bone: stiffness | 0.6 | 1.0 | 5.6 | 0.3 | 2.4 | -0.4 | 0.5 | -0.0 | 0.8 | -0.5 |
| Distance traveled before self-admin | 0.6 | 0.7 | 1.8 | 1.3 | -0.8 | 0.5 | -0.7 | -1.2 | -0.3 | 0.4 |
| Rb content in liver | 0.6 | 0.7 | 1.7 | -1.1 | 0.9 | -0.6 | 0.7 | 1.3 | 0.7 | 0.1 |
| Sr content in liver | 0.6 | 0.6 | 3.0 | 0.1 | -1.7 | 0.4 | -0.4 | -0.3 | -0.7 | 0.4 |
| Heart weight | 0.5 | 0.7 | 2.1 | -1.5 | 0.2 | -0.7 | 0.8 | 1.3 | 0.1 | -0.1 |
| Soleus weight | 0.5 | 1.6 | 6.2 | -0.2 | 1.5 | -1.1 | 1.0 | -0.2 | 2.5 | 0.4 |
| Water consumed over 24 hours | 0.5 | 0.6 | 1.2 | 1.1 | -0.4 | 1.0 | -1.0 | -0.7 | -0.7 | 0.2 |
| Reaction time mean minus median AUC | 0.5 | 0.6 | 1.5 | -1.2 | 0.6 | -0.7 | 0.8 | 1.1 | 0.3 | -0.1 |
| Reaction time false alarm rate | 0.5 | 0.8 | 1.8 | 1.0 | 0.5 | 0.6 | -0.8 | -1.3 | 0.6 | 0.9 |
| Cocaine response before conditioning | 0.5 | 0.6 | 2.1 | -1.0 | -1.4 | 0.1 | 0.0 | 0.8 | -0.8 | 0.1 |
| Intermittent access total locomotion | 0.5 | 0.6 | 1.8 | -1.3 | 0.2 | -0.4 | 0.5 | 1.2 | -0.1 | 0.8 |
| Short access day 10 total inactive lever presses | 0.5 | 0.6 | 1.3 | 0.5 | -0.2 | 0.9 | -0.9 | -0.7 | -0.4 | 1.1 |
| Short access day 1 locomotion | 0.5 | 0.5 | 1.4 | -0.6 | -1.2 | 0.5 | -0.4 | 0.5 | -0.8 | 0.7 |
| Total zone transitions, NPP test | 0.5 | 0.7 | 2.0 | -0.8 | -1.4 | 0.3 | -0.3 | 0.6 | -0.7 | 1.0 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.7 | 1.3 | 1.1 | -0.0 | 0.9 | -0.9 | -1.0 | -0.8 | 0.1 |
| Bone: cortical apparent density | 0.5 | 0.6 | 1.6 | 1.2 | 0.8 | 0.2 | -0.3 | -1.3 | 0.4 | -0.4 |
| Bone: cortical tissue density | 0.5 | 0.6 | 1.8 | 1.2 | 0.7 | 0.2 | -0.4 | -1.3 | 0.4 | -0.4 |
| Bone: trabecular thickness | 0.5 | 0.6 | 3.1 | 0.1 | 1.8 | -0.3 | 0.4 | 0.1 | 0.1 | -0.9 |
| Vertical activity count, locomotor time 1 | 0.5 | 0.6 | 1.1 | -0.6 | 0.7 | -0.6 | 0.6 | 0.5 | 1.0 | 1.0 |
| Locomotion in novel chamber post-restriction | 0.5 | 0.6 | 1.5 | -1.1 | -0.8 | 0.1 | 0.1 | 1.2 | -0.3 | 0.8 |
| Parametrial fat weight | 0.4 | 0.8 | 1.3 | 1.1 | -1.1 | 0.4 | -0.6 | -0.9 | 0.9 | 1.0 |
| Reaction time number correct | 0.4 | 0.5 | 2.3 | 0.1 | -0.7 | 0.6 | -0.6 | -0.2 | -1.5 | 0.3 |
| Reaction time trials correct on left | 0.4 | 0.5 | 2.3 | 0.1 | -0.7 | 0.6 | -0.6 | -0.2 | -1.5 | 0.3 |
| Reaction time trials on left | 0.4 | 0.6 | 2.3 | 0.1 | -0.8 | 0.7 | -0.6 | -0.2 | -1.5 | 0.3 |
| Reaction time mean AUC | 0.4 | 0.5 | 1.0 | 1.0 | 1.0 | 0.6 | -0.6 | -1.0 | 0.1 | -0.0 |
| Reaction time trials completed | 0.4 | 0.6 | 2.3 | 0.1 | -0.8 | 0.7 | -0.6 | -0.2 | -1.5 | 0.3 |
| Intermittent access intake escalation 2 | 0.4 | 0.4 | 1.5 | -0.7 | -0.5 | -0.2 | 0.1 | 0.3 | 0.8 | 1.2 |
| Intermitt. access day 1 inactive lever presses | 0.4 | 0.5 | 0.7 | 0.7 | 0.8 | 0.6 | -0.6 | -0.8 | 0.3 | 0.7 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.5 | 1.4 | -0.5 | -0.0 | -0.0 | 0.1 | 0.9 | -0.8 | 1.2 |
| Post-drug Anxiety | 0.4 | 0.4 | 1.8 | 0.7 | 1.4 | 0.0 | -0.0 | -0.6 | 0.3 | -0.3 |
| Progressive ratio test 2 inactive lever presses | 0.4 | 0.5 | 1.7 | -1.3 | 0.3 | -0.0 | 0.1 | 1.0 | -0.4 | 0.7 |
| Short access day 1 total inactive lever presses | 0.4 | 0.4 | 1.8 | -0.1 | 0.8 | 0.6 | -0.5 | 0.0 | -0.2 | 1.3 |
| Number of responses in last shaping day | 0.4 | 0.4 | 1.6 | -0.5 | 1.3 | -0.4 | 0.4 | 0.3 | 0.6 | 0.2 |
| Locomotion distance, session 1 | 0.4 | 0.5 | 1.2 | -1.1 | -1.1 | -0.1 | 0.1 | 0.7 | -0.5 | 0.5 |
| Locomotion velocity, session 7 | 0.4 | 0.4 | 1.0 | 0.5 | -1.0 | 0.5 | -0.5 | -0.7 | -0.7 | -0.2 |
| Condit. Reinf. active responses | 0.4 | 0.5 | 1.8 | -0.5 | 1.4 | -0.6 | 0.6 | 0.3 | 0.5 | -0.3 |
| Locomotion velocity, hab. session 1 | 0.4 | 0.6 | 1.4 | 0.1 | 1.2 | -0.9 | 0.7 | -0.2 | 1.1 | -0.6 |
| Bone surface | 0.4 | 0.7 | 1.6 | -1.3 | 0.8 | -0.6 | 0.8 | 1.1 | 0.5 | -0.1 |
| Breakpoint value in progressive ratio session | 0.4 | 0.4 | 0.9 | 0.6 | -0.9 | 0.5 | -0.5 | -0.6 | -0.9 | -0.2 |
| Time in open arm after self-admin | 0.4 | 0.5 | 1.9 | -0.3 | 0.6 | -0.5 | 0.5 | 0.0 | 1.4 | -0.8 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 2.0 | 0.4 | -0.3 | -0.1 | 0.1 | 0.3 | -0.7 | -1.4 |
| Total heroin consumption | 0.4 | 0.5 | 1.0 | -0.8 | -0.1 | -0.7 | 0.7 | 0.7 | -0.4 | -1.0 |
| Delay disc. indifference point, 16s delay | 0.4 | 0.4 | 0.8 | 0.8 | 0.9 | 0.5 | -0.5 | -0.7 | -0.4 | -0.5 |
| Time >=10cm from walls, locomotor time 1 | 0.4 | 0.4 | 1.2 | -1.1 | 0.4 | -0.3 | 0.4 | 0.7 | -0.3 | -0.6 |
| Distance moved, locomotor task time 1 | 0.4 | 0.4 | 1.6 | -0.3 | 0.1 | -0.7 | 0.6 | 0.3 | 1.3 | 0.6 |
| Latency to leave start box in cocaine runway, F | 0.4 | 0.5 | 1.1 | 0.7 | 0.7 | 0.0 | -0.1 | -1.0 | 1.0 | 0.6 |
| BMI with tail | 0.3 | 1.0 | 3.9 | 0.5 | -2.0 | 0.2 | -0.4 | -1.2 | 0.4 | 0.9 |
| Epididymis fat weight | 0.3 | 0.7 | 2.7 | 1.0 | 0.4 | -0.4 | 0.2 | -0.9 | 1.6 | -0.4 |
| Tibialis anterior weight | 0.3 | 0.9 | 1.6 | -0.4 | 1.3 | -1.1 | 1.1 | 0.5 | 1.2 | -0.8 |
| Tibia length | 0.3 | 0.9 | 3.0 | -1.4 | 0.5 | -0.3 | 0.6 | 1.7 | -0.8 | 0.0 |
| Indifference point function ln k | 0.3 | 0.5 | 2.0 | -0.2 | -0.7 | 0.6 | -0.5 | 0.3 | -1.4 | -0.0 |
| Indifference point function log k | 0.3 | 0.5 | 2.0 | -0.2 | -0.7 | 0.6 | -0.5 | 0.3 | -1.4 | -0.0 |
| Delay discounting water rate 24 sec | 0.3 | 0.4 | 1.3 | -0.8 | -1.1 | 0.2 | -0.1 | 0.4 | -1.0 | 0.1 |
| Delay discounting water rate 6 sec | 0.3 | 0.5 | 1.4 | -1.2 | -0.8 | -0.5 | 0.5 | 0.8 | -0.1 | -0.1 |
| Reaction time mean | 0.3 | 0.5 | 1.4 | 0.8 | 1.2 | 0.3 | -0.4 | -0.9 | 0.4 | 0.0 |
| Progressive ratio test 1 inactive lever presses | 0.3 | 0.3 | 0.9 | -0.9 | 0.4 | -0.1 | 0.2 | 0.8 | 0.3 | 0.8 |
| Short access day 10 total locomotion | 0.3 | 0.3 | 1.3 | -0.4 | -0.1 | -0.3 | 0.3 | 0.7 | 0.4 | 1.2 |
| Locomotion velocity, session 3 | 0.3 | 0.4 | 0.8 | -0.9 | -0.0 | -0.2 | 0.3 | 0.9 | -0.7 | -0.5 |
| Locomotion distance, session 3 | 0.3 | 0.3 | 0.8 | -0.7 | -0.6 | 0.1 | 0.1 | 0.8 | -0.9 | -0.2 |
| Time in familiar zone, hab. session 1 | 0.3 | 0.3 | 0.8 | -0.0 | 0.2 | -0.7 | 0.6 | 0.4 | 0.5 | -0.9 |
| Total locomotion distance, NPP test | 0.3 | 0.4 | 1.4 | -0.0 | 0.1 | -0.8 | 0.6 | -0.3 | 1.2 | 0.1 |
| Bone: apparent density | 0.3 | 0.5 | 0.8 | 0.5 | -0.5 | 0.9 | -0.9 | -0.5 | -0.8 | 0.8 |
| Bone volume | 0.3 | 0.5 | 1.1 | -1.0 | 0.8 | -0.5 | 0.6 | 0.9 | 0.3 | 0.0 |
| Bone: final force | 0.3 | 0.4 | 2.8 | 0.3 | 1.7 | -0.2 | 0.2 | -0.1 | 0.1 | -0.3 |
| Bone: final moment | 0.3 | 0.4 | 2.6 | 0.1 | 1.6 | -0.3 | 0.4 | 0.2 | 0.3 | -0.3 |
| Bone: trabecular spacing | 0.3 | 0.4 | 0.9 | -0.8 | -0.8 | -0.5 | 0.4 | 0.9 | 0.2 | 0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.3 | 0.2 | 0.8 | -0.9 | -0.4 | 0.2 | -0.1 | 0.8 | -0.2 | 0.2 |
| Bouts of movement, locomotor time 1 | 0.3 | 0.4 | 1.1 | -0.5 | 0.8 | -0.0 | 0.1 | 0.6 | -0.2 | 1.1 |
| Total resting periods, locomotor time 1 | 0.3 | 0.3 | 1.0 | -0.2 | 0.2 | 0.6 | -0.5 | 0.2 | -0.7 | 1.0 |
| Rest time, locomotor task time 1 | 0.3 | 0.3 | 1.1 | 0.1 | 0.4 | 0.4 | -0.2 | -0.2 | -1.0 | -1.0 |
| Progressive ratio | 0.3 | 0.3 | 1.0 | 0.3 | -1.0 | 0.5 | -0.5 | -0.5 | -0.5 | 0.3 |
| Run reversals in cocaine runway, males | 0.3 | 0.3 | 0.7 | 0.4 | -0.2 | 0.8 | -0.8 | -0.5 | -0.3 | -0.6 |
| Times rat made contact with spout | 0.2 | 0.2 | 0.8 | 0.4 | 0.6 | -0.2 | 0.1 | 0.1 | 0.9 | 0.1 |
| Delay discounting total patch changes 6 sec | 0.2 | 0.3 | 0.8 | -0.9 | -0.0 | -0.7 | 0.7 | 0.4 | 0.2 | 0.0 |
| Locomotor activity | 0.2 | 0.4 | 0.7 | -0.8 | -0.0 | -0.8 | 0.8 | 0.7 | 0.2 | -0.1 |
| Reaction time trials AUC | 0.2 | 0.3 | 1.6 | 0.1 | -0.5 | 0.5 | -0.4 | -0.2 | -1.3 | 0.2 |
| Social response proportion | 0.2 | 0.3 | 1.0 | 0.4 | 0.2 | -0.2 | 0.1 | -0.3 | 0.8 | 1.0 |
| Conditioned locomotion | 0.2 | 0.3 | 1.0 | 0.4 | 1.0 | 0.1 | -0.1 | -0.3 | -0.7 | -0.2 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 0.7 | -0.4 | 0.5 | 0.3 | -0.2 | 0.4 | -0.5 | 0.8 |
| Locomotion velocity, session 2 | 0.2 | 0.3 | 0.7 | -0.7 | -0.8 | -0.2 | 0.1 | 0.6 | 0.2 | 0.5 |
| Locomotion distance, session 2 | 0.2 | 0.3 | 0.7 | -0.8 | -0.8 | -0.4 | 0.4 | 0.6 | -0.1 | 0.5 |
| Stereotopy head waving bouts, day 3 | 0.2 | 0.3 | 1.0 | -0.2 | 1.0 | -0.5 | 0.4 | 0.1 | 0.6 | -0.1 |
| Condit. Reinf. inactive responses | 0.2 | 0.2 | 0.7 | 0.3 | -0.0 | 0.4 | -0.5 | -0.5 | -0.4 | 0.8 |
| Condit. Reinf. lever presses | 0.2 | 0.2 | 0.9 | -0.6 | 0.2 | 0.1 | -0.1 | 0.4 | 0.3 | 0.9 |
| Total zone transitions, hab. session 1 | 0.2 | 0.3 | 1.0 | -0.5 | -0.8 | 0.4 | -0.3 | 0.5 | -1.0 | 0.2 |
| Locomotion velocity, NPP test | 0.2 | 0.3 | 1.1 | 0.3 | -0.1 | -0.5 | 0.3 | -0.6 | 1.1 | 0.3 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.5 | -0.5 | 0.1 | 0.4 | -0.2 | 0.6 | -0.7 | 0.3 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.6 | -0.5 | 0.2 | 0.4 | -0.2 | 0.6 | -0.8 | 0.2 |
| Bone: maximum force | 0.2 | 0.3 | 1.8 | -0.1 | 1.3 | -0.2 | 0.3 | 0.2 | 0.2 | -0.2 |
| Bone: maximum moment | 0.2 | 0.3 | 1.4 | -0.2 | 1.2 | -0.4 | 0.5 | 0.5 | 0.3 | -0.1 |
| Delta time to tail flick, test, before/after SA | 0.2 | 0.2 | 0.7 | 0.3 | 0.0 | 0.0 | -0.1 | -0.8 | 0.3 | -0.4 |
| Cd content in liver | 0.2 | 0.3 | 0.5 | 0.6 | 0.1 | 0.3 | -0.4 | -0.7 | 0.7 | 0.5 |
| K content in liver | 0.2 | 0.2 | 0.7 | 0.2 | 0.3 | 0.1 | -0.2 | -0.2 | 0.4 | 0.8 |
| Na content in liver | 0.2 | 0.2 | 0.7 | -0.5 | -0.1 | -0.0 | 0.1 | 0.8 | -0.2 | 0.4 |
| Glucose | 0.1 | 0.2 | 1.0 | -0.0 | -1.0 | 0.4 | -0.4 | 0.2 | -0.4 | -0.1 |
| Extensor digitorum longus weight | 0.1 | 0.4 | 2.2 | 0.4 | 0.1 | -0.4 | 0.2 | -0.4 | 1.5 | 0.2 |
| Reaction time omissions | 0.1 | 0.2 | 0.4 | 0.5 | -0.1 | 0.3 | -0.4 | -0.5 | 0.3 | 0.6 |
| Conditioned reinforcement - inactives | 0.1 | 0.2 | 0.8 | -0.1 | 0.9 | 0.1 | -0.1 | -0.2 | 0.4 | 0.3 |
| Intermitt. access escalation Index | 0.1 | 0.1 | 0.2 | -0.5 | 0.5 | -0.2 | 0.2 | 0.2 | 0.3 | -0.1 |
| Intermittent access standard deviation | 0.1 | 0.2 | 0.6 | -0.1 | -0.6 | 0.0 | -0.1 | 0.2 | 0.4 | 0.8 |
| Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.3 | -0.3 | 0.1 | 0.0 | 0.0 | 0.4 | -0.2 | 0.6 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | -0.1 | 0.1 | 0.4 | 0.1 | 0.4 |
| Short access total locomotion | 0.1 | 0.1 | 0.3 | -0.1 | -0.3 | 0.2 | -0.1 | 0.4 | -0.2 | 0.5 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.2 | -0.5 | -0.3 | -0.1 | 0.1 | 0.3 | -0.3 | 0.3 |
| Locomotion distance, session 7 | 0.1 | 0.1 | 0.4 | 0.4 | 0.2 | 0.1 | -0.1 | -0.6 | 0.0 | -0.2 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.3 | 0.1 | 0.2 | 0.4 | -0.4 | -0.6 | -0.1 | 0.0 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.3 | 0.1 | -0.4 | 0.2 | -0.3 | -0.3 | -0.3 | 0.5 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.2 | -0.5 | 0.3 | -0.1 | 0.1 | 0.3 | -0.3 | 0.3 |
| Bone: post-yield work | 0.1 | 0.2 | 0.5 | -0.4 | 0.3 | -0.5 | 0.5 | 0.3 | 0.1 | -0.7 |
| Extinction: sum of active levers before priming | 0.1 | 0.1 | 0.7 | 0.3 | -0.1 | 0.2 | -0.2 | -0.2 | 0.1 | -0.8 |
| Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.2 | 0.1 | 0.2 | -0.3 | 0.3 | 0.4 | -0.3 | -0.4 |
| Area under the delay curve | 0.1 | 0.1 | 0.3 | 0.3 | 0.5 | 0.4 | -0.4 | -0.3 | 0.2 | 0.3 |
| Delay disc. indifference point, 8s delay | 0.1 | 0.1 | 0.5 | 0.1 | 0.1 | 0.4 | -0.4 | -0.4 | 0.0 | 0.7 |
| Delay discount exponential model param | 0.1 | 0.2 | 0.3 | -0.3 | -0.4 | -0.5 | 0.5 | 0.4 | -0.2 | -0.3 |
| Delay discount hyperbolic model param | 0.1 | 0.1 | 0.3 | -0.0 | -0.6 | -0.2 | 0.3 | 0.0 | -0.5 | -0.3 |
| Fe content in liver | 0.1 | 0.1 | 0.8 | 0.1 | 0.9 | 0.0 | 0.0 | 0.2 | 0.2 | -0.0 |
| Mg content in liver | 0.1 | 0.1 | 0.3 | -0.5 | -0.0 | -0.2 | 0.2 | 0.4 | 0.3 | 0.5 |
| Length without tail | 0.0 | 0.1 | 0.3 | 0.3 | 0.6 | 0.1 | -0.2 | -0.1 | -0.3 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.