Hub : Genes

Rce1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	ENSRNOT00000066455	0.03	0.02	2.6e-03	0.02	0.02	0.02	0.02	4.6e-03	8.2e-03	8.5e-03	4.9e-03
2	Brain	intron excision ratio	chr1:201900007:201900284	0.03	0.02	3.5e-03	0.01	0.01	0	0.01	3.1e-02	1.7e-02	9.3e-02	7.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.1	0.3	0.5	-0.7	0.4
BMI without tail	0.0	0.0	0.0	-0.0	-0.0
Body weight	1.1	4.7	5.3	2.0	-2.3
Epididymis fat weight	2.2	5.2	5.7	-2.2	2.4
Glucose	3.7	5.7	5.7	-2.4	2.4
Heart weight	1.7	2.5	3.1	-1.4	1.8
Left kidney weight	0.1	0.2	0.3	-0.3	0.5
Right kidney weight	0.0	0.0	0.0	0.2	-0.0
Tail length	2.3	7.0	7.1	2.6	-2.7
Length with tail	2.9	10.7	11.4	3.2	-3.4
Length without tail	1.5	3.3	3.8	1.7	-1.9
Liver weight, left	0.0	0.0	0.0	0.2	-0.1
Liver weight, right	0.0	0.1	0.1	0.3	-0.3
Parametrial fat weight	2.4	4.7	5.6	-2.0	2.4
Retroperitoneal fat weight	3.7	12.4	13.5	-3.3	3.7
Intraocular pressure	0.0	0.0	0.0	0.1	0.1
Extensor digitorum longus weight	4.1	16.6	18.4	3.9	-4.3
Soleus weight	1.4	4.1	4.3	-2.1	2.0
Tibialis anterior weight	9.0	31.2	33.5	5.4	-5.8
Tibia length	0.6	1.8	2.0	1.3	-1.4
Number of licking bursts	0.0	0.0	0.0	0.1	-0.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.2
Times rat made contact with spout	0.0	0.0	0.0	0.0	-0.1
Mean time between licks in bursts	0.4	0.6	0.8	0.7	-0.9
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.3
Std. dev. time between licks in bursts	1.1	1.3	1.4	1.2	-1.1
Water consumed over 24 hours	0.3	0.4	0.4	0.6	-0.5
Indifference point 0 sec	0.3	0.5	0.5	-0.7	0.7
Indifference point AUC	2.4	2.8	3.1	1.8	-1.6
Indifference point function ln k	2.5	3.6	3.7	-1.9	1.9
Indifference point function log k	2.5	3.6	3.7	-1.9	1.9
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.0	0.1
Delay discounting total patch changes 12 sec	1.7	2.2	2.4	1.5	-1.4
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	0.4	-0.2
Delay discounting total patch changes 24 sec	1.9	2.4	2.4	1.6	-1.5
Delay discounting total patch changes 6 sec	0.2	0.2	0.3	0.6	-0.4
Delay discounting time to switch 0 sec	0.1	0.2	0.3	-0.6	0.2
Delay discounting water rate 0 sec	0.1	0.1	0.2	-0.1	0.5
Delay discounting water rate 12 sec	0.3	0.4	0.6	-0.5	0.8
Delay discounting water rate 18 sec	0.3	0.5	0.5	-0.7	0.7
Delay discounting water rate 24 sec	0.1	0.1	0.2	-0.1	0.4
Delay discounting water rate 6 sec	0.0	0.0	0.0	0.2	-0.0
Locomotor activity	0.0	0.0	0.0	0.1	-0.0
Locomotor testing distance	0.0	0.0	0.0	0.1	0.0
Locomotor testing rearing	0.4	0.7	0.9	-0.7	1.0
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.2
Light reinforcement 2	0.7	0.9	1.0	-0.9	1.0
Reaction time number correct	0.9	1.3	1.5	1.2	-1.1
Reaction time mean minus median	0.5	0.7	0.9	0.7	-0.9
Reaction time mean minus median AUC	1.3	1.7	1.9	1.2	-1.4
Reaction time num false alarms	0.8	1.1	1.3	1.2	-0.9
Reaction time num false alarms AUC	1.5	2.1	2.3	1.5	-1.4
Reaction time trials correct on left	0.9	1.3	1.5	1.2	-1.1
Reaction time trials on left	1.2	1.7	1.8	1.4	-1.3
Reaction time mean	0.1	0.1	0.1	-0.4	0.2
Reaction time mean AUC	0.2	0.2	0.3	-0.6	0.3
Median of all reaction times	0.3	0.4	0.5	-0.7	0.5
Reaction time omissions	1.3	1.8	1.8	1.3	-1.3
Reaction time false alarm rate	0.3	0.5	0.5	0.7	-0.6
Reaction time premature initiation rate	2.3	3.0	3.4	1.6	-1.9
Reaction time premature initiations	4.5	6.4	6.9	2.4	-2.6
Std. dev. reaction times	0.1	0.1	0.2	0.2	-0.5
Reaction time trials completed	1.2	1.7	1.8	1.4	-1.3
Reaction time trials AUC	0.9	1.2	1.3	1.2	-1.1
Social response proportion	0.0	0.0	0.1	-0.3	0.1
Social responses	0.3	0.3	0.4	0.6	-0.6
Social time	0.5	0.7	0.8	0.9	-0.7
Conditioned locomotion	2.9	3.5	3.8	1.8	-1.9
Cocaine response after cond. corrected	0.1	0.2	0.2	-0.3	0.4
Cocaine response after cond. not corrected	0.4	0.4	0.5	-0.6	0.7
Cocaine response before conditioning	0.0	0.0	0.0	-0.2	0.1
Saline control response	1.2	1.6	1.7	1.3	-1.3
Condit. Reinf. active minus inactive responses	1.5	1.8	2.0	-1.3	1.4
Condit. Reinf. active-inactive response ratio	2.2	2.3	2.4	-1.5	1.6
Condit. Reinf. active responses	1.2	1.7	1.8	-1.3	1.3
Condit. Reinf. inactive responses	0.2	0.2	0.2	-0.5	0.4
Condit. Reinf. lever presses	0.0	0.1	0.1	0.2	-0.3
Condit. Reinf. lever reinforcers received	0.8	1.1	1.2	-1.0	1.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.3	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.5	0.2
Pavlov. Cond. index score	0.1	0.1	0.1	0.1	-0.3
Pavlov. Cond. latency score	0.0	0.1	0.1	0.1	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	-0.4
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.7	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	-0.5
Pavlov. Cond. response bias	0.1	0.2	0.2	0.3	-0.5
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	0.2
Conditioned reinforcement - inactives	3.5	4.0	4.3	-1.9	2.1
Conditioned locomotion	2.1	2.5	2.8	-1.5	1.7
Intermittent access intake day 1-15 change	0.0	0.0	0.0	0.2	-0.0
Intermittent access intake escalation	0.0	0.0	0.1	-0.1	0.2
Intermittent access intake escalation 2	0.1	0.1	0.2	0.5	-0.3
Intermitt. access day 1 inactive lever presses	2.1	2.3	2.4	-1.5	1.5
Intermitt. access day 15 inactive lever presses	1.7	1.9	1.9	-1.4	1.4
Intermitt. access escalation Index	3.1	2.8	3.0	-1.6	1.7
Intermittent access day 1 total infusions	10.4	11.8	12.1	-3.5	3.4
Intermittent access day 15 total infusions	7.3	8.1	8.4	-2.8	2.9
Intermittent access terminal intake (last 3 days)	6.4	7.0	7.2	-2.6	2.7
Intermittent access total infusions	7.5	8.3	8.4	-2.9	2.8
Intermittent access day 1 locomotion	7.6	7.7	8.0	-2.8	2.7
Intermittent access day 15 total locomotion	5.3	5.7	5.7	-2.4	2.4
Intermittent access total locomotion	11.2	12.6	13.1	-3.6	3.5
Intermittent access standard deviation	0.2	0.2	0.2	-0.3	0.5
Cocaine induced anxiety	0.1	0.1	0.1	0.3	-0.2
Post-drug Anxiety	1.8	2.0	2.0	1.4	-1.4
Baseline Anxiety	2.2	2.3	2.5	1.5	-1.6
Lifetime Intake	6.7	7.5	7.6	-2.8	2.7
Incentive Sensitization - Responses	0.9	0.9	1.0	-1.0	1.0
Incentive Sensitization - Breakpoint	1.1	1.1	1.1	-1.1	1.0
Progressive ratio test 1 active lever presses	2.2	2.2	2.3	-1.5	1.5
Progressive ratio test 1 breakpoint	1.6	1.6	1.7	-1.2	1.3
Progressive ratio test 1 inactive lever presses	1.2	1.3	1.3	-1.1	1.2
Progressive ratio test 2 active lever presses	4.0	4.2	4.3	-2.0	2.1
Progressive ratio test 2 breakpoint	3.2	3.5	3.7	-1.8	1.9
Progressive ratio test 2 inactive lever presses	8.7	10.0	10.3	-3.1	3.2
Total sessions with >9 infusions	2.1	2.3	2.3	-1.5	1.5
Short access day 1 total inactive lever presses	3.2	3.6	3.8	-1.9	1.9
Short access day 10 total inactive lever presses	1.1	1.2	1.2	-1.1	1.1
Short access day 1 total infusions	5.8	6.1	6.3	-2.4	2.5
Short access day 10 total infusions	6.8	7.5	8.0	-2.8	2.6
Short access total infusions	3.4	3.7	3.7	-1.9	1.9
Short access day 1 locomotion	4.8	5.1	5.2	-2.3	2.2
Short access day 10 total locomotion	3.9	4.3	4.6	-2.1	2.0
Short access total locomotion	3.6	3.7	3.9	-2.0	1.9
Compulsive drug intake	4.5	4.4	4.6	2.1	-2.1
One hour access (0.3 mA shock)	6.7	7.8	7.9	-2.8	2.8
One hour access (shock baseline)	8.0	9.2	9.4	-3.0	3.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.4
Context. condit. distance diff. score	0.6	0.8	1.1	-0.7	1.1
Locomotion velocity, session 1	0.2	0.2	0.3	0.3	-0.5
Locomotion distance, session 1	0.4	0.5	0.8	-0.9	0.4
Locomotion velocity, session 2	0.6	0.8	1.1	0.7	-1.0
Locomotion distance, session 2	0.0	0.0	0.0	-0.2	-0.2
Locomotion velocity, session 3	0.5	0.6	0.8	-0.9	0.7
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1
Stereotopy head waving bouts, day 3	0.7	0.8	0.9	-0.9	1.0
Stereotopy head waving duration, day 3	1.3	1.6	1.6	-1.3	1.3
Locomotion velocity, session 7	0.9	1.0	1.0	-1.0	1.0
Locomotion distance, session 7	0.0	0.0	0.0	-0.0	-0.0
Stereotopy head waving bouts, day 7	1.1	1.3	1.6	-1.0	1.3
Stereotopy head waving duration, day 7	0.2	0.3	0.3	-0.5	0.6
Locomotion velocity, session 8	1.0	1.3	1.5	1.0	-1.2
Locomotion distance, session 8	0.3	0.5	0.5	-0.7	0.7
Degree of sensitization distance	0.0	0.0	0.1	-0.2	0.2
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.1	0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.4	0.4
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.2
Incentive salience index mean	0.0	0.0	0.1	-0.2	0.1
Condit. Reinf. lever presses	0.0	0.1	0.1	0.1	-0.3
Time in familiar zone, hab. session 1	1.2	1.1	1.3	-1.1	1.0
Time in novel zone, hab. session 1	0.5	0.5	0.6	0.8	-0.6
Total zone transitions, hab. session 1	0.2	0.2	0.3	0.4	-0.5
Total locomotion distance, hab. session 1	0.3	0.4	0.4	-0.6	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.3	0.3
Time in familiar zone, hab. session 2	0.8	0.9	0.9	0.9	-0.9
Time in novel zone, hab. session 2	0.8	0.8	0.8	-0.9	0.9
Total zone transitions, hab. session 2	0.8	1.0	1.2	-1.1	0.9
Total locomotion distance, hab. session 2	0.9	1.3	1.4	-1.1	1.2
Locomotion velocity, hab. session 2	1.3	1.8	1.9	-1.3	1.4
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	0.3
Novelty place preference	0.3	0.3	0.3	-0.5	0.6
Time in novel zone, NPP test	0.3	0.3	0.3	-0.5	0.6
Total zone transitions, NPP test	0.1	0.1	0.1	0.2	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, NPP test	0.0	0.1	0.1	-0.3	0.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.1
Pavlov. Cond. magazine entry latency	0.9	1.2	1.3	-1.2	1.0
Pavlov. Cond. change in total contacts	0.8	0.8	0.9	-1.0	0.8
Pavlov. Cond. index score	0.1	0.1	0.1	-0.3	0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.2	0.1
Bone: apparent density	1.0	1.7	1.8	-1.3	1.3
Bone surface	0.1	0.1	0.2	-0.4	0.2
Bone volume	0.5	0.9	0.9	-1.0	0.9
Bone: connectivity density	0.3	0.5	0.6	-0.8	0.5
Bone: cortical apparent density	0.5	0.7	0.7	0.8	-0.8
Bone: cortical area	0.7	1.0	1.3	0.9	-1.1
Bone: cortical porosity	0.3	0.3	0.3	-0.6	0.5
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.0
Bone: cortical thickness	5.9	9.8	10.4	3.0	-3.2
Bone: cortical thickness	3.6	4.3	4.6	2.0	-2.1
Bone: cortical tissue density	0.7	0.9	0.9	1.0	-0.9
Bone: elastic displacement	0.9	1.0	1.1	1.1	-0.9
Bone: elastic work	3.4	4.4	4.5	2.1	-2.1
Bone: endosteal estimation	2.5	5.4	5.7	-2.3	2.4
Bone: endosteal perimeter	5.4	11.0	11.9	-3.4	3.2
Bone: final force	0.7	1.2	1.4	1.0	-1.2
Bone: final moment	0.6	1.0	1.2	0.9	-1.1
Bone: marrow area	2.6	5.6	5.9	-2.3	2.4
Bone: maximum diameter	0.1	0.1	0.2	-0.4	0.1
Bone: maximum force	0.0	0.0	0.1	-0.0	-0.3
Bone: maximum moment	0.0	0.0	0.1	-0.0	-0.3
Bone: minimum diameter	3.1	5.7	5.8	-2.4	2.4
Bone: periosteal estimation	0.2	0.4	0.4	-0.6	0.6
Bone: periosteal perimeter	0.4	0.7	0.9	-1.0	0.7
Bone: post-yield work	7.4	10.0	11.0	-3.3	3.0
Bone: stiffness	0.1	0.1	0.1	-0.4	0.2
Bone: tissue strength	0.3	0.3	0.3	-0.5	0.6
Bone: trabecular number	0.8	1.3	1.3	-1.1	1.1
Bone: trabecular spacing	0.0	0.0	0.1	0.0	-0.3
Bone: trabecular thickness	1.7	2.1	2.6	-1.3	1.6
Bone: trabecular tissue density	0.8	1.2	1.3	-1.0	1.1
Breakpoint value in progressive ratio session	1.1	1.3	1.5	1.0	-1.2
Distance traveled before self-admin	0.0	0.0	0.0	0.2	-0.2
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	0.0
Delta time in closed arm before/after self-admin	1.3	1.3	1.5	1.2	-1.0
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.0	0.1
Diff in mean of infusions in LGA sessions	0.7	0.8	0.8	0.9	-0.9
Extinction: sum of active levers before priming	0.7	0.7	0.9	0.7	-0.9
Active lever presses in extinction session 6	2.7	2.6	2.6	1.6	-1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	-0.3
Time in closed arm before self-admin	0.4	0.4	0.4	-0.7	0.6
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	-0.1
Time in open arm before self-admin	0.0	0.1	0.1	0.2	-0.3
Time in open arm after self-admin	0.1	0.1	0.1	0.3	-0.3
Sum of active levers in priming session hrs 5-6	2.4	2.4	2.4	1.5	-1.5
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	0.0
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.4	0.6	-0.6
Time to tail flick, test, before self-admin	1.3	1.3	1.4	-1.2	1.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.2	-0.3
Delta time to tail flick, test, before/after SA	3.8	3.4	3.7	1.9	-1.8
Ambulatory time before self-admin	0.0	0.0	0.0	-0.2	0.1
Ambulatory time after self-admin	1.5	1.6	1.9	-1.4	1.2
Total heroin consumption	2.5	3.0	3.2	1.7	-1.8
Area under the delay curve	0.9	1.0	1.2	-1.1	0.9
Delay disc. indifference point, 0s delay	0.7	0.8	0.8	-0.8	0.9
Delay disc. indifference point, 16s delay	3.0	3.0	3.5	-1.9	1.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	-0.5	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	-0.4
Delay disc. indifference point, 4s delay	0.2	0.3	0.3	-0.5	0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.4
Delay discount exponential model param	0.6	0.6	0.8	0.9	-0.7
Delay discount hyperbolic model param	0.5	0.5	0.6	0.7	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.1	0.1
Change in fecal boli incidents, locomotor task	0.2	0.1	0.3	-0.5	0.1
Time >=10cm from walls, locomotor time 1	5.1	5.2	5.5	-2.4	2.2
Bouts of movement, locomotor time 1	0.3	0.4	0.5	0.5	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.2	-0.4
Rest time, locomotor task time 1	0.3	0.4	0.4	-0.6	0.6
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.5	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.3	0.6
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.6	0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.2	0.3	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	-0.1
Rest time, locomotor task time 2	1.1	1.2	1.5	-1.0	1.2
Distance moved, locomotor task time 2	0.6	0.7	0.8	0.8	-0.9
Vertical activity count, locomotor time 2	1.9	2.0	2.3	1.5	-1.3
Weight adjusted by age	1.8	2.0	2.1	1.4	-1.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.9	-0.9	0.7
Locomotion in novel chamber	3.4	4.2	4.2	-2.0	2.0
Locomotion in novel chamber post-restriction	1.3	1.6	1.8	-1.2	1.3
Progressive ratio	0.3	0.3	0.4	-0.6	0.5
Food seeking constrained by brief footshock	0.5	0.6	0.7	0.8	-0.8
Seeking ratio, punishment vs. effort	0.2	0.3	0.3	0.6	-0.5
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	0.0
Run reversals in cocaine runway, males	2.1	2.0	2.2	1.5	-1.4
Latency to leave start box in cocaine runway	1.0	1.0	1.1	-1.1	1.0
Latency to leave start box in cocaine runway, F	0.3	0.4	0.4	-0.6	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.2
Cd content in liver	0.3	0.3	0.4	-0.5	0.6
Co content in liver	0.5	0.6	0.8	0.9	-0.6
Cu content in liver	0.0	0.0	0.0	0.1	-0.2
Fe content in liver	0.2	0.2	0.3	0.5	-0.4
K content in liver	0.1	0.1	0.1	-0.3	-0.0
Mg content in liver	2.4	2.4	2.8	-1.7	1.4
Mn content in liver	0.5	0.5	0.7	0.6	-0.8
Na content in liver	0.7	0.8	0.9	0.8	-1.0
Rb content in liver	2.6	3.2	3.5	-1.7	1.9
Se content in liver	0.9	1.1	1.1	-1.1	1.0
Sr content in liver	3.6	3.3	3.3	1.8	-1.8
Zn content in liver	0.3	0.3	0.4	0.5	-0.6