Chp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000019112	0.56	0.15	0.0e+00	0.32	0.44	0.44	0.44	1.3e-35	7.3e-54	9.6e-54	1.5e-53
2	BLA	gene expression	ENSRNOG00000019112	0.12	0.08	2.2e-04	0.04	0.05	0.02	0.05	2.8e-03	1.2e-03	2.4e-02	1.4e-03
3	LHb	gene expression	ENSRNOG00000019112	0.57	0.17	1.8e-08	0.24	0.21	0.21	0.23	1.7e-06	1.1e-05	1.1e-05	4.0e-06
4	Liver	gene expression	ENSRNOG00000019112	0.14	0.09	2.1e-12	0.1	0.09	0.08	0.09	7.8e-11	3.4e-10	3.7e-09	1.7e-10
5	PL	gene expression	ENSRNOG00000019112	0.04	0.03	4.6e-03	0.02	0.03	0.01	0.03	9.9e-03	2.9e-03	2.8e-02	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.4	1.2	1.7	1.0	-1.3	1.2	1.0	-1.0
BMI without tail	1.0	2.1	3.4	1.1	-1.7	1.9	1.6	-0.7
Body weight	0.5	2.3	3.8	1.2	-1.7	1.9	1.8	-0.6
Epididymis fat weight	0.1	0.2	0.4	-0.3	0.1	-0.2	-0.6	0.5
Glucose	0.3	0.4	1.4	0.5	-0.3	0.0	0.6	-1.2
Heart weight	0.6	0.9	3.0	0.3	0.2	-0.8	-1.7	-0.7
Left kidney weight	0.6	1.7	2.6	1.2	-1.6	1.6	1.4	-0.5
Right kidney weight	0.8	2.2	3.4	1.4	-1.8	1.8	1.5	-0.6
Tail length	0.9	2.6	4.9	1.4	-1.8	2.2	1.5	-0.8
Length with tail	0.3	1.3	2.4	0.9	-1.1	1.6	1.4	-0.1
Length without tail	0.0	0.1	0.4	0.2	-0.1	0.3	0.6	0.2
Liver weight, left	0.1	0.2	0.7	0.1	0.0	-0.2	-0.4	-0.8
Liver weight, right	0.6	1.0	1.5	1.2	-1.2	0.9	0.3	-1.1
Parametrial fat weight	0.7	1.3	2.4	1.1	-0.9	0.7	1.2	-1.5
Retroperitoneal fat weight	0.3	0.9	2.6	-0.6	0.9	-1.0	-1.6	0.1
Intraocular pressure	0.0	0.0	0.0	-0.2	0.0	0.1	-0.0	0.0
Extensor digitorum longus weight	2.6	10.3	15.8	2.7	-3.4	4.0	3.9	-1.3
Soleus weight	1.4	4.0	4.9	1.9	-2.1	2.2	2.1	-1.7
Tibialis anterior weight	5.6	19.4	26.2	4.1	-4.7	5.1	4.9	-2.8
Tibia length	0.1	0.2	0.3	0.5	-0.5	0.4	-0.1	-0.5
Number of licking bursts	5.6	6.7	9.4	-2.5	2.9	-3.1	-2.6	1.6
Food consumed during 24 hour testing period	2.1	2.5	3.4	1.5	-1.6	1.7	1.8	-1.3
Times rat made contact with spout	1.0	1.1	1.7	0.9	-1.1	1.3	1.3	-0.4
Mean time between licks in bursts	0.0	0.0	0.1	0.2	0.1	-0.1	-0.2	-0.4
Mean num. licks in bursts	7.7	9.3	13.2	3.0	-3.4	3.6	3.1	-1.8
Std. dev. time between licks in bursts	0.1	0.2	0.6	0.5	-0.1	-0.0	0.2	-0.8
Water consumed over 24 hours	0.4	0.4	1.2	-0.6	0.4	-0.2	-0.6	1.1
Indifference point 0 sec	2.1	3.4	4.1	2.0	-2.0	1.6	1.6	-1.9
Indifference point AUC	1.5	1.8	3.8	1.6	-1.3	0.9	0.4	-2.0
Indifference point function ln k	0.3	0.5	1.2	0.3	-0.6	0.8	1.1	0.3
Indifference point function log k	0.3	0.5	1.2	0.3	-0.6	0.8	1.1	0.3
Delay discounting total patch changes 0 sec	1.9	3.0	3.8	2.0	-1.9	1.5	1.3	-1.9
Delay discounting total patch changes 12 sec	0.8	1.1	2.0	1.2	-1.0	0.7	0.5	-1.4
Delay discounting total patch changes 18 sec	0.3	0.4	0.9	0.8	-0.6	0.3	-0.1	-0.9
Delay discounting total patch changes 24 sec	1.6	2.0	3.6	1.8	-1.4	1.0	0.5	-1.9
Delay discounting total patch changes 6 sec	3.1	4.8	8.9	2.6	-2.2	1.6	1.0	-3.0
Delay discounting time to switch 0 sec	1.9	2.9	4.7	-1.7	1.4	-1.2	-1.8	2.2
Delay discounting water rate 0 sec	0.5	0.7	0.9	0.9	-0.9	0.7	0.8	-1.0
Delay discounting water rate 12 sec	0.2	0.3	0.5	-0.7	0.7	-0.7	0.3	0.2
Delay discounting water rate 18 sec	0.0	0.0	0.1	0.1	-0.0	-0.0	0.3	-0.2
Delay discounting water rate 24 sec	0.0	0.0	0.1	-0.2	0.0	-0.0	0.2	0.1
Delay discounting water rate 6 sec	0.2	0.3	1.3	0.5	-0.3	-0.0	0.2	-1.2
Locomotor activity	0.9	1.5	2.2	1.5	-1.3	1.4	0.9	-1.0
Locomotor testing distance	1.1	1.8	3.1	1.8	-1.5	1.4	0.1	-1.3
Locomotor testing rearing	0.3	0.5	1.9	0.3	0.1	-0.3	-1.4	-0.4
Light reinforcement 1	0.4	0.7	1.1	-0.8	1.0	-0.9	-0.6	0.7
Light reinforcement 2	0.1	0.1	0.3	-0.1	0.2	0.2	0.5	-0.2
Reaction time number correct	1.1	1.6	2.3	-1.2	1.5	-1.3	-1.4	0.9
Reaction time mean minus median	0.1	0.1	0.2	0.4	-0.3	0.2	0.1	-0.3
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0	-0.3
Reaction time num false alarms	0.3	0.5	0.8	-0.8	0.8	-0.9	-0.3	0.4
Reaction time num false alarms AUC	0.2	0.2	0.4	-0.6	0.5	-0.6	0.1	0.4
Reaction time trials correct on left	1.1	1.6	2.3	-1.2	1.5	-1.3	-1.4	0.9
Reaction time trials on left	1.2	1.7	2.4	-1.2	1.6	-1.3	-1.3	0.9
Reaction time mean	0.4	0.5	0.7	0.9	-0.8	0.7	0.6	-0.5
Reaction time mean AUC	0.4	0.5	0.7	0.9	-0.8	0.8	0.5	-0.5
Median of all reaction times	0.5	0.7	0.9	0.9	-0.9	0.9	0.9	-0.6
Reaction time omissions	0.4	0.6	1.7	-0.8	0.7	-0.5	0.0	1.3
Reaction time false alarm rate	0.0	0.1	0.3	-0.2	-0.2	0.0	0.5	0.1
Reaction time premature initiation rate	0.5	0.7	2.4	-0.7	0.6	-0.2	0.2	1.5
Reaction time premature initiations	1.5	2.1	4.7	-1.5	1.5	-1.0	-0.6	2.2
Std. dev. reaction times	0.2	0.2	0.5	0.7	-0.5	0.5	-0.1	-0.4
Reaction time trials completed	1.2	1.7	2.4	-1.2	1.6	-1.3	-1.3	0.9
Reaction time trials AUC	1.0	1.4	2.0	-1.1	1.4	-1.2	-1.3	0.8
Social response proportion	0.1	0.1	0.7	0.1	0.2	-0.1	-0.8	-0.1
Social responses	0.4	0.5	0.6	-0.7	0.7	-0.8	-0.8	0.5
Social time	0.2	0.2	1.0	0.2	0.1	-0.2	-1.0	-0.4
Conditioned locomotion	0.2	0.2	0.9	-0.3	-0.0	0.2	-0.4	0.9
Cocaine response after cond. corrected	1.2	1.3	2.1	-1.1	1.1	-1.2	-1.5	0.7
Cocaine response after cond. not corrected	0.2	0.3	0.7	-0.5	0.4	-0.4	-0.8	0.4
Cocaine response before conditioning	1.7	2.1	3.2	1.4	-1.6	1.8	1.4	-0.7
Saline control response	1.2	1.5	3.2	1.5	-1.2	0.9	0.5	-1.8
Condit. Reinf. active minus inactive responses	1.7	2.1	4.3	1.6	-1.2	0.9	1.2	-2.1
Condit. Reinf. active-inactive response ratio	1.2	1.3	3.9	1.2	-0.7	0.3	0.7	-2.0
Condit. Reinf. active responses	1.2	1.6	2.3	1.4	-1.2	1.1	1.1	-1.5
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.5	-0.7	1.0	0.5	0.3
Condit. Reinf. lever presses	2.6	3.5	4.5	2.1	-2.0	1.9	1.7	-1.7
Condit. Reinf. lever reinforcers received	0.7	1.0	1.8	1.2	-0.9	0.7	0.8	-1.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.6	0.5	-0.5	-0.9	0.5
Pavlov. Cond. magazine entry latency	2.9	3.4	4.0	-1.7	2.0	-2.0	-1.9	1.5
Pavlov. Cond. change in total contacts	0.2	0.3	1.0	0.3	0.2	-0.4	0.4	-1.0
Pavlov. Cond. index score	0.4	0.6	1.0	-0.6	1.0	-1.0	-0.6	0.3
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.7	0.9	-0.9	-0.6	0.4
Pavlov. Cond. lever contacts	0.6	0.8	1.5	0.9	-0.7	0.7	1.2	-0.8
Pavlov. Cond. magazine entry number	2.1	2.6	3.9	1.5	-1.9	2.0	1.5	-1.0
Pavlov. Cond. intertrial magazine entries	2.0	2.6	4.0	1.5	-1.8	2.0	1.6	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.3	-0.8	1.1	-1.1	-0.7	0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.1	0.4	-0.5	0.0	-0.1
Conditioned reinforcement - actives	0.3	0.3	0.7	0.6	-0.8	0.7	-0.1	-0.4
Conditioned reinforcement - inactives	2.1	2.4	3.7	1.9	-1.9	1.4	0.4	-1.7
Conditioned locomotion	0.4	0.5	1.4	-0.6	0.2	-0.3	-0.9	1.2
Intermittent access intake day 1-15 change	0.2	0.2	0.7	-0.1	0.2	-0.8	-0.3	-0.3
Intermittent access intake escalation	0.4	0.4	1.3	-0.3	0.5	-1.2	-0.6	-0.1
Intermittent access intake escalation 2	1.1	1.1	2.8	-0.6	1.0	-1.7	-1.2	0.1
Intermitt. access day 1 inactive lever presses	1.1	1.2	1.8	1.4	-1.3	0.9	-0.8	-1.0
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.4	1.2	-1.6	1.4	0.8	-0.3
Intermitt. access escalation Index	0.2	0.2	0.9	0.1	0.0	0.1	1.0	-0.2
Intermittent access day 1 total infusions	3.5	3.9	5.8	2.0	-2.3	2.4	1.2	-1.7
Intermittent access day 15 total infusions	0.7	0.8	1.3	1.0	-1.1	0.7	0.0	-1.2
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.3	1.3	-1.3	1.0	0.7	-1.5
Intermittent access total infusions	3.6	3.9	5.1	2.1	-2.3	2.0	1.6	-1.9
Intermittent access day 1 locomotion	2.6	2.7	3.8	1.7	-2.0	1.7	1.0	-1.7
Intermittent access day 15 total locomotion	0.6	0.6	2.1	0.6	-0.6	-0.3	-0.4	-1.4
Intermittent access total locomotion	3.3	3.7	5.5	2.1	-2.2	1.5	1.3	-2.3
Intermittent access standard deviation	0.4	0.4	0.9	0.6	-0.4	-0.0	-0.8	-1.0
Cocaine induced anxiety	0.2	0.2	0.4	0.6	-0.3	-0.2	-0.4	-0.6
Post-drug Anxiety	0.3	0.3	0.7	-0.2	0.7	-0.9	-0.3	-0.5
Baseline Anxiety	0.1	0.2	0.3	-0.4	0.5	-0.0	0.6	0.1
Lifetime Intake	2.2	2.5	3.1	1.5	-1.8	1.8	1.4	-1.4
Incentive Sensitization - Responses	0.4	0.4	0.9	0.4	-0.9	0.8	-0.1	0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.2	0.5	-1.1	1.0	0.2	0.1
Progressive ratio test 1 active lever presses	1.9	1.9	2.3	1.4	-1.5	1.4	1.1	-1.5
Progressive ratio test 1 breakpoint	2.1	2.2	2.5	1.4	-1.6	1.6	1.2	-1.6
Progressive ratio test 1 inactive lever presses	2.3	2.4	3.9	1.7	-2.0	1.8	1.0	-1.0
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	0.4	-0.8	0.7	-0.1	-0.3
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	0.6	-1.0	0.8	0.2	-0.5
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.5	1.2	-1.2	1.0	0.1	-0.8
Total sessions with >9 infusions	1.3	1.4	2.7	0.8	-1.4	1.6	1.2	-0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.5	0.5	-0.5	0.7	0.3	0.2
Short access day 10 total inactive lever presses	0.5	0.5	0.9	0.9	-0.7	0.8	-0.5	-0.7
Short access day 1 total infusions	0.1	0.1	0.3	-0.2	-0.2	0.6	-0.0	0.5
Short access day 10 total infusions	1.4	1.6	3.2	1.0	-1.6	1.8	0.7	-0.7
Short access total infusions	1.3	1.4	2.6	0.9	-1.3	1.6	1.3	-0.8
Short access day 1 locomotion	0.2	0.2	0.6	-0.0	-0.5	0.8	0.3	0.4
Short access day 10 total locomotion	3.7	4.0	6.9	2.3	-2.6	2.1	0.7	-1.7
Short access total locomotion	4.5	4.6	6.9	2.3	-2.6	2.2	1.2	-2.2
Compulsive drug intake	0.3	0.3	0.4	-0.7	0.6	-0.4	-0.3	0.6
One hour access (0.3 mA shock)	0.9	1.1	2.2	1.1	-1.1	0.9	0.1	-1.5
One hour access (shock baseline)	0.7	0.8	2.3	1.0	-0.9	0.4	-0.2	-1.5
Number of responses in last shaping day	0.8	0.8	1.6	0.9	-1.2	1.3	0.6	-0.3
Context. condit. distance diff. score	2.4	2.9	3.6	-1.7	1.9	-1.9	-1.7	1.3
Locomotion velocity, session 1	0.1	0.1	0.5	-0.0	-0.1	0.2	0.7	-0.1
Locomotion distance, session 1	0.1	0.1	0.2	-0.5	0.4	-0.4	0.2	0.1
Locomotion velocity, session 2	0.0	0.0	0.1	0.1	-0.2	0.2	0.1	-0.0
Locomotion distance, session 2	0.1	0.1	0.4	-0.3	0.0	0.1	0.7	0.2
Locomotion velocity, session 3	0.5	0.6	1.1	0.5	-0.8	1.0	1.0	-0.1
Locomotion distance, session 3	0.3	0.3	0.8	0.2	-0.6	0.7	0.9	0.2
Stereotopy head waving bouts, day 3	0.7	0.9	1.7	0.8	-0.6	0.6	1.2	-1.3
Stereotopy head waving duration, day 3	0.7	0.8	1.7	0.7	-0.6	0.6	1.3	-1.1
Locomotion velocity, session 7	2.1	2.3	5.1	-1.9	1.4	-0.9	-0.3	2.3
Locomotion distance, session 7	2.4	3.0	4.1	-2.0	1.9	-1.6	-1.0	2.0
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.4	-0.6	0.7	0.7	-0.2
Stereotopy head waving duration, day 7	0.7	0.8	1.4	0.8	-1.0	1.2	1.0	-0.4
Locomotion velocity, session 8	0.0	0.0	0.1	-0.1	0.1	-0.0	0.3	-0.1
Locomotion distance, session 8	0.8	1.2	1.7	-1.3	1.2	-1.1	-0.7	1.0
Degree of sensitization distance	2.4	2.4	3.6	-1.5	1.8	-1.9	-1.5	0.8
Degree of sensitization stereotypy	0.2	0.2	0.5	0.2	-0.6	0.7	0.2	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	-0.3	0.3	-0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.6	0.6	-0.0	-0.2
Condit. Reinf. active responses	0.2	0.2	0.5	0.6	-0.4	0.3	-0.2	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.0	0.2	-0.4	-0.3	-0.6
Incentive salience index mean	0.4	0.5	0.9	0.8	-0.9	1.0	0.3	-0.2
Condit. Reinf. lever presses	0.5	0.6	1.1	0.7	-0.9	1.1	0.9	-0.2
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.1	0.1	-0.5	-0.9	-0.9
Time in novel zone, hab. session 1	1.3	1.3	4.3	-1.1	0.6	-0.0	0.7	2.1
Total zone transitions, hab. session 1	0.8	1.1	1.5	1.0	-1.0	0.9	1.1	-1.2
Total locomotion distance, hab. session 1	1.1	1.6	2.5	1.1	-1.3	1.5	1.6	-0.8
Locomotion velocity, hab. session 1	1.1	1.6	1.9	1.2	-1.4	1.4	1.4	-1.0
Time in familiar zone, hab. session 2	1.5	1.5	2.5	1.4	-1.3	1.0	0.8	-1.6
Time in novel zone, hab. session 2	2.0	2.0	2.5	-1.6	1.6	-1.4	-0.9	1.5
Total zone transitions, hab. session 2	0.9	1.1	1.5	0.9	-1.1	1.1	1.2	-0.9
Total locomotion distance, hab. session 2	0.5	0.7	1.3	0.5	-0.9	1.0	1.2	-0.4
Locomotion velocity, hab. session 2	1.2	1.6	2.4	1.0	-1.4	1.5	1.6	-0.7
Novel to familiar place preference ratio	0.0	0.0	0.1	0.1	0.0	-0.1	-0.3	-0.2
Novelty place preference	0.0	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.2
Time in novel zone, NPP test	0.1	0.1	0.2	0.0	0.2	-0.3	-0.4	-0.2
Total zone transitions, NPP test	0.2	0.3	0.8	0.3	-0.4	0.5	0.9	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.5	0.3	-0.2	0.3	0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.5	0.3	-0.1	0.4	0.5
Pavlov. Cond. lever latency	0.7	0.9	1.8	-0.5	0.9	-1.2	-1.3	0.0
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.1	-0.3	0.6	0.2	0.7
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	0.3	-0.7	1.0	0.7	0.7
Pavlov. Cond. index score	0.2	0.3	0.6	0.2	-0.5	0.8	0.5	0.5
Pavlov. Cond. latency score	0.3	0.4	0.8	0.3	-0.7	0.9	0.7	0.3
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.3	-0.7	1.0	1.0	0.4
Pavlov. Cond. magazine entry number	0.2	0.2	1.0	0.3	0.0	-0.3	0.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	-0.0	0.5	-0.8	-0.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	1.0	0.3	-0.7	1.0	0.7	0.4
Pavlov. Cond. response bias	0.2	0.3	1.2	-0.3	-0.1	0.4	-0.1	1.1
Bone: apparent density	0.8	1.4	1.7	1.2	-1.2	1.1	0.9	-1.3
Bone surface	1.4	2.4	3.1	1.5	-1.6	1.7	1.7	-1.2
Bone volume	1.2	2.1	2.6	1.4	-1.5	1.6	1.6	-1.2
Bone: connectivity density	0.6	0.9	1.1	1.1	-1.0	1.0	0.7	-1.0
Bone: cortical apparent density	0.4	0.5	0.7	0.8	-0.6	0.4	-0.6	-0.9
Bone: cortical area	2.7	4.1	4.6	2.1	-2.1	2.1	1.9	-1.8
Bone: cortical porosity	0.3	0.3	0.8	0.1	-0.3	0.6	0.9	0.5
Bone: cortical porosity	0.3	0.3	0.6	0.0	-0.3	0.6	0.8	0.6
Bone: cortical thickness	1.4	2.3	2.7	1.6	-1.6	1.4	1.3	-1.6
Bone: cortical thickness	0.1	0.1	0.3	0.2	-0.0	-0.1	0.4	-0.6
Bone: cortical tissue density	0.3	0.4	0.6	0.8	-0.6	0.3	-0.6	-0.8
Bone: elastic displacement	0.1	0.1	0.2	0.3	-0.2	0.1	0.1	-0.5
Bone: elastic work	1.2	1.6	2.2	1.2	-1.1	1.2	1.5	-1.3
Bone: endosteal estimation	0.6	1.3	2.0	1.0	-1.1	1.3	1.4	-0.7
Bone: endosteal perimeter	0.1	0.2	0.5	0.2	-0.4	0.6	0.7	0.2
Bone: final force	5.4	8.9	11.9	2.8	-2.9	3.0	3.5	-2.7
Bone: final moment	4.8	8.0	10.7	2.7	-2.7	2.8	3.3	-2.6
Bone: marrow area	0.6	1.2	1.9	0.9	-1.1	1.3	1.4	-0.6
Bone: maximum diameter	1.5	2.7	3.1	1.7	-1.7	1.8	1.6	-1.4
Bone: maximum force	4.7	8.2	10.3	2.8	-2.9	2.9	3.2	-2.5
Bone: maximum moment	4.1	7.1	9.0	2.6	-2.6	2.7	3.0	-2.4
Bone: minimum diameter	1.2	2.2	2.7	1.4	-1.6	1.6	1.6	-1.0
Bone: periosteal estimation	2.1	4.2	5.0	2.0	-2.1	2.2	2.2	-1.6
Bone: periosteal perimeter	0.3	0.5	0.8	0.7	-0.8	0.9	0.9	-0.3
Bone: post-yield work	1.7	2.3	3.4	1.4	-1.7	1.8	1.7	-0.8
Bone: stiffness	4.9	7.8	8.5	2.8	-2.9	2.9	2.9	-2.5
Bone: tissue strength	0.1	0.1	0.3	-0.3	0.1	0.1	0.5	0.3
Bone: trabecular number	0.7	1.1	1.6	1.2	-1.1	0.9	0.4	-1.3
Bone: trabecular spacing	1.2	1.5	2.8	-1.4	1.2	-1.0	-0.5	1.7
Bone: trabecular thickness	0.7	0.8	2.0	0.9	-0.8	0.5	0.6	-1.4
Bone: trabecular tissue density	0.2	0.3	0.4	0.6	-0.5	0.5	0.5	-0.7
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.1	0.2	0.2	0.6	-0.6
Distance traveled before self-admin	0.4	0.5	1.1	-1.0	0.6	-0.3	0.7	0.6
Distance traveled after self-admin	0.6	0.7	2.5	-0.8	0.2	-0.2	1.6	0.6
Delta time in closed arm before/after self-admin	2.3	2.2	4.0	-1.5	1.4	-1.1	-1.4	2.0
Delta time in open arm before/after self-admin	7.5	7.1	10.8	2.6	-2.5	2.2	2.6	-3.3
Diff in mean of infusions in LGA sessions	0.3	0.4	0.7	-0.6	0.7	-0.9	-0.1	-0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.3	-0.2	0.2	0.3	-0.5
Active lever presses in extinction session 6	0.3	0.3	0.7	0.3	-0.1	0.2	0.8	-0.8
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.1	-0.3	0.3	0.5	0.3
Delta ambulatory time before/after self-admin	0.5	0.6	0.8	0.8	-0.9	0.9	0.7	-0.3
Time in closed arm before self-admin	0.3	0.3	1.3	-0.4	0.3	-0.3	-1.1	0.3
Time in closed arm after self-admin	4.4	4.6	8.8	-1.8	2.0	-1.9	-3.0	1.9
Time in open arm before self-admin	0.4	0.4	0.7	-0.4	0.8	-0.8	0.4	0.4
Time in open arm after self-admin	6.8	7.5	10.7	2.7	-2.5	2.3	3.3	-2.9
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.9	0.8	-0.6	0.9	1.7	-0.6
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	0.1	-0.2	0.2	-0.2
Time to tail flick, vehicle, after self-admin	1.9	2.1	3.7	-1.7	1.9	-1.7	-0.4	0.9
Time to tail flick, test, before self-admin	0.3	0.3	1.0	0.5	-0.5	0.6	1.0	-0.0
Time to tail flick, test, after self-admin	0.9	0.9	3.6	-0.2	0.2	-0.5	-1.9	0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.4	-0.3	0.2	0.1
Delta time to tail flick, test, before/after SA	0.6	0.5	2.3	-0.1	-0.0	-0.3	-1.5	0.3
Ambulatory time before self-admin	0.7	0.7	1.6	-1.2	0.9	-0.6	0.6	0.6
Ambulatory time after self-admin	0.6	0.7	2.6	-0.7	0.1	0.1	1.6	0.6
Total heroin consumption	0.1	0.2	0.4	-0.0	-0.1	0.4	0.6	-0.5
Area under the delay curve	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.0
Delay disc. indifference point, 16s delay	2.0	2.0	3.1	-1.1	1.7	-1.7	-1.8	0.5
Delay disc. indifference point, 2s delay	3.4	3.8	6.0	1.8	-1.9	2.1	2.4	-1.4
Delay disc. indifference point, 24s delay	0.4	0.4	1.7	-0.1	0.4	-0.5	-1.3	0.1
Delay disc. indifference point, 4s delay	0.1	0.2	0.3	0.5	-0.4	0.4	-0.0	-0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.4	-0.3	0.7	0.3	0.0
Delay discount exponential model param	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2	0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.2	0.3
Fecal boli incidents, locomotor time 1	1.4	1.5	4.2	-0.8	0.7	-0.9	-2.0	1.2
Change in fecal boli incidents, locomotor task	1.7	1.6	2.6	1.1	-1.0	1.1	1.6	-1.4
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.2	0.9	-1.4	1.5	0.9	-0.1
Bouts of movement, locomotor time 1	1.2	1.3	2.1	-1.0	1.3	-1.5	-1.2	0.7
Total resting periods, locomotor time 1	0.8	0.9	1.2	-0.8	1.0	-1.1	-1.1	0.6
Rest time, locomotor task time 1	1.2	1.3	2.0	-1.2	1.0	-0.9	-1.1	1.4
Distance moved, locomotor task time 1	3.3	3.6	4.5	2.1	-2.1	1.8	1.3	-2.1
Vertical activity count, locomotor time 1	3.3	3.4	4.3	2.0	-1.9	1.6	1.6	-2.1
Time >=10cm from walls, locomotor time 2	1.8	1.9	3.8	1.1	-1.7	1.9	1.4	-0.1
Bouts of movement, locomotor time 2	0.5	0.6	1.3	0.7	-0.9	1.1	0.4	0.0
Total resting periods, locomotor time 2	0.2	0.3	0.7	0.3	-0.6	0.8	0.3	0.3
Rest time, locomotor task time 2	0.7	0.8	1.3	-1.2	1.0	-0.8	-0.8	0.8
Distance moved, locomotor task time 2	2.0	2.3	3.4	1.7	-1.8	1.7	1.0	-1.2
Vertical activity count, locomotor time 2	2.1	2.3	3.3	1.7	-1.8	1.5	1.0	-1.4
Weight adjusted by age	0.5	0.5	0.8	0.9	-0.8	0.8	-0.3	-0.6
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	1.6	-0.9	1.2	-1.0	-0.4	1.3
Locomotion in novel chamber	0.5	0.6	1.9	0.9	-0.4	0.2	-0.1	-1.4
Locomotion in novel chamber post-restriction	2.7	3.2	6.4	-1.8	2.2	-2.5	-1.2	0.1
Progressive ratio	0.5	0.6	1.1	-0.8	0.9	-1.0	-0.5	0.3
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.1	-0.2
Seeking ratio, punishment vs. effort	0.7	0.9	1.5	0.9	-1.0	1.2	1.1	-0.3
Run reversals in cocaine runway, females	1.3	1.3	2.4	0.9	-1.2	1.3	1.5	-0.3
Run reversals in cocaine runway, males	1.5	1.5	2.1	-1.5	1.4	-1.1	0.8	1.1
Latency to leave start box in cocaine runway	0.3	0.3	0.4	-0.5	0.7	-0.4	0.6	-0.4
Latency to leave start box in cocaine runway, F	1.6	1.7	2.7	-1.7	1.6	-1.4	-0.7	1.0
Latency to leave start box in cocaine runway, M	1.2	1.1	2.1	1.0	-0.8	0.8	1.1	-1.4
Cd content in liver	1.6	1.8	2.9	-1.1	1.4	-1.5	-1.7	0.8
Co content in liver	2.1	2.5	2.8	1.6	-1.7	1.5	1.4	-1.6
Cu content in liver	2.6	3.1	4.6	1.6	-1.7	1.8	2.1	-1.5
Fe content in liver	0.6	0.7	1.3	-0.2	0.7	-1.2	-1.1	-0.7
K content in liver	3.0	3.0	4.6	1.5	-1.7	2.0	2.1	-1.0
Mg content in liver	0.4	0.4	1.2	0.2	-0.4	0.7	1.1	0.0
Mn content in liver	0.2	0.2	0.4	0.4	-0.6	0.6	0.4	-0.2
Na content in liver	2.6	2.8	4.6	1.5	-1.8	2.1	1.9	-0.3
Rb content in liver	0.9	1.2	2.5	1.1	-0.8	0.6	1.1	-1.6
Se content in liver	0.4	0.5	0.7	0.8	-0.6	0.5	0.5	-0.9
Sr content in liver	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.2	0.1
Zn content in liver	0.8	0.9	2.6	0.1	-0.7	1.1	1.6	0.5