# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000018873 | 0.0730 | 0.0450 | 6.6e-08 | 0.053 | 0.055 | 0.053 | 0.055 | 1.4e-06 | 9.2e-07 | 1.4e-06 | 9.0e-07 |
2 | Adipose | isoform ratio | ENSRNOT00000025827 | 0.0840 | 0.0540 | 3.9e-09 | 0.060 | 0.067 | 0.061 | 0.061 | 3.0e-07 | 5.7e-08 | 2.7e-07 | 2.5e-07 |
3 | Adipose | isoform ratio | ENSRNOT00000097710 | 0.0900 | 0.0590 | 2.1e-09 | 0.072 | 0.069 | 0.069 | 0.068 | 2.0e-08 | 4.1e-08 | 4.1e-08 | 4.7e-08 |
4 | BLA | gene expression | ENSRNOG00000018873 | 0.2990 | 0.1240 | 6.3e-14 | 0.224 | 0.242 | 0.246 | 0.237 | 3.3e-12 | 3.6e-13 | 2.0e-13 | 6.5e-13 |
5 | BLA | intron excision ratio | chr1:155057563:155142249 | 0.0950 | 0.0740 | 5.7e-03 | 0.022 | 0.000 | 0.003 | 0.004 | 2.4e-02 | 3.2e-01 | 2.0e-01 | 1.8e-01 |
6 | BLA | intron excision ratio | chr1:155077476:155142249 | 0.1600 | 0.1300 | 3.8e-04 | 0.049 | 0.028 | 0.024 | 0.047 | 1.3e-03 | 1.2e-02 | 1.8e-02 | 1.5e-03 |
7 | Brain | gene expression | ENSRNOG00000018873 | 0.3000 | 0.1200 | 0.0e+00 | 0.234 | 0.331 | 0.330 | 0.326 | 1.7e-21 | 1.9e-31 | 2.2e-31 | 6.1e-31 |
8 | Brain | isoform ratio | ENSRNOT00000025827 | 0.1353 | 0.0951 | 8.3e-08 | 0.057 | 0.085 | 0.085 | 0.076 | 4.9e-06 | 2.8e-08 | 2.6e-08 | 1.6e-07 |
9 | Brain | isoform ratio | ENSRNOT00000095174 | 0.1109 | 0.0860 | 1.2e-05 | 0.049 | 0.062 | 0.058 | 0.050 | 2.3e-05 | 2.2e-06 | 4.6e-06 | 1.9e-05 |
10 | Brain | intron excision ratio | chr1:155057563:155142249 | 0.0505 | 0.0378 | 3.0e-03 | 0.010 | 0.009 | 0.012 | 0.007 | 3.6e-02 | 4.5e-02 | 2.4e-02 | 6.1e-02 |
11 | Brain | intron excision ratio | chr1:155077476:155142249 | 0.0539 | 0.0387 | 1.6e-03 | 0.017 | 0.017 | 0.021 | 0.022 | 9.5e-03 | 8.5e-03 | 4.4e-03 | 3.9e-03 |
12 | Brain | intron excision ratio | chr1:155176815:155187558 | 0.1802 | 0.0977 | 2.3e-12 | 0.130 | 0.137 | 0.121 | 0.126 | 4.3e-12 | 1.3e-12 | 2.9e-11 | 1.0e-11 |
13 | Brain | intron excision ratio | chr1:155182402:155187558 | 0.0567 | 0.0384 | 6.5e-05 | 0.043 | 0.036 | 0.024 | 0.032 | 7.3e-05 | 2.5e-04 | 2.4e-03 | 5.2e-04 |
14 | LHb | gene expression | ENSRNOG00000018873 | 0.4439 | 0.1998 | 4.2e-07 | 0.090 | 0.210 | 0.215 | 0.194 | 3.7e-03 | 9.9e-06 | 7.7e-06 | 2.3e-05 |
15 | Liver | gene expression | ENSRNOG00000018873 | 0.0720 | 0.0570 | 3.9e-04 | 0.006 | 0.013 | 0.010 | 0.008 | 6.7e-02 | 1.2e-02 | 2.5e-02 | 4.1e-02 |
16 | Liver | intron excision ratio | chr1:155077476:155142249 | 0.0360 | 0.0286 | 7.4e-03 | 0.011 | 0.004 | 0.000 | 0.004 | 1.8e-02 | 1.1e-01 | 3.2e-01 | 1.0e-01 |
17 | NAcc | gene expression | ENSRNOG00000018873 | 0.1300 | 0.0790 | 1.2e-09 | 0.115 | 0.127 | 0.119 | 0.115 | 7.3e-09 | 1.1e-09 | 3.5e-09 | 7.0e-09 |
18 | PL | gene expression | ENSRNOG00000018873 | 0.1807 | 0.1091 | 2.9e-11 | 0.070 | 0.090 | 0.136 | 0.046 | 5.4e-06 | 2.3e-07 | 1.6e-10 | 1.9e-04 |
19 | PL | intron excision ratio | chr1:155057563:155142249 | 0.0496 | 0.0462 | 3.6e-03 | 0.020 | 0.019 | 0.032 | 0.016 | 1.2e-02 | 1.2e-02 | 1.8e-03 | 2.0e-02 |
20 | PL | intron excision ratio | chr1:155182402:155187558 | 0.0384 | 0.0295 | 3.4e-03 | 0.029 | 0.027 | 0.034 | 0.026 | 2.8e-03 | 3.6e-03 | 1.3e-03 | 4.2e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pavlov. Cond. response bias | 13.6 | 18.8 | 32.8 | -3.9 | 4.9 | -3.5 | -5.3 | -2.7 | 2.7 | -5.3 | 5.4 | -5.7 | -4.1 | 3.3 | -5.7 | 5.7 | -0.2 | 4.5 | 2.7 | -4.2 | 4.0 | 3.8 | 4.9 |
Pavlov. Cond. lever contacts | 13.5 | 18.8 | 32.9 | -3.7 | 4.8 | -3.4 | -5.2 | -3.0 | 3.0 | -5.2 | 5.4 | -5.7 | -4.3 | 3.5 | -5.7 | 5.7 | 0.1 | 4.6 | 2.9 | -4.0 | 3.9 | 3.6 | 4.8 |
Condit. Reinf. lever presses | 13.0 | 17.8 | 31.9 | -3.3 | 4.5 | -3.0 | -5.1 | -3.3 | 3.3 | -5.0 | 5.3 | -5.5 | -4.4 | 3.7 | -5.6 | 5.6 | 0.3 | 4.7 | 3.1 | -3.6 | 3.6 | 3.4 | 4.5 |
Pavlov. Cond. lever latency | 12.9 | 17.7 | 31.2 | 3.6 | -4.6 | 3.2 | 5.0 | 3.0 | -3.0 | 5.1 | -5.2 | 5.5 | 4.2 | -3.4 | 5.6 | -5.6 | -0.0 | -4.5 | -2.9 | 3.9 | -3.7 | -3.5 | -4.7 |
Pavlov. Cond. change in total contacts | 10.6 | 14.8 | 24.3 | -3.5 | 4.4 | -3.5 | -4.4 | -2.3 | 2.3 | -4.7 | 4.8 | -4.9 | -3.6 | 2.8 | -4.9 | 4.9 | -0.0 | 3.8 | 2.4 | -3.8 | 4.4 | 3.4 | 4.4 |
Pavlov. Cond. index score | 10.0 | 13.0 | 23.0 | -3.2 | 4.1 | -2.9 | -4.5 | -2.2 | 2.2 | -4.5 | 4.5 | -4.8 | -3.3 | 2.7 | -4.8 | 4.7 | -0.2 | 3.7 | 2.2 | -3.5 | 3.2 | 3.3 | 4.0 |
Pavlov. Cond. lever-magazine prob. diff. | 9.3 | 12.1 | 21.5 | -3.0 | 3.9 | -2.7 | -4.3 | -2.3 | 2.3 | -4.3 | 4.3 | -4.6 | -3.3 | 2.7 | -4.6 | 4.6 | -0.1 | 3.7 | 2.3 | -3.3 | 3.0 | 3.0 | 3.8 |
Pavlov. Cond. latency score | 8.9 | 11.2 | 19.6 | -3.1 | 3.9 | -2.9 | -4.2 | -1.9 | 1.9 | -4.2 | 4.1 | -4.4 | -3.0 | 2.3 | -4.4 | 4.4 | -0.3 | 3.4 | 1.9 | -3.3 | 3.1 | 3.1 | 3.9 |
Condit. Reinf. lever reinforcers received | 8.4 | 11.9 | 21.2 | -1.9 | 3.0 | -2.0 | -3.7 | -3.5 | 3.5 | -3.6 | 4.1 | -4.3 | -4.3 | 3.8 | -4.4 | 4.6 | 1.4 | 4.3 | 3.4 | -2.3 | 3.1 | 1.8 | 3.2 |
Condit. Reinf. active responses | 7.7 | 10.7 | 19.0 | -1.6 | 2.7 | -1.5 | -3.4 | -3.6 | 3.6 | -3.2 | 3.9 | -4.0 | -4.3 | 3.9 | -4.2 | 4.4 | 1.6 | 4.2 | 3.5 | -1.9 | 2.6 | 1.5 | 2.8 |
Condit. Reinf. active minus inactive responses | 5.8 | 7.2 | 13.1 | -1.5 | 2.4 | -1.7 | -3.0 | -2.6 | 2.6 | -2.8 | 3.1 | -3.3 | -3.3 | 2.9 | -3.4 | 3.6 | 1.0 | 3.4 | 2.5 | -1.8 | 2.5 | 1.5 | 2.6 |
Pavlov. Cond. magazine entry number | 5.4 | 6.7 | 11.3 | 2.8 | -3.3 | 2.7 | 3.3 | 0.7 | -0.7 | 3.4 | -3.1 | 3.3 | 1.6 | -1.0 | 3.3 | -3.1 | 0.9 | -2.0 | -0.7 | 3.0 | -2.6 | -2.9 | -3.2 |
Mean time between licks in bursts | 5.2 | 7.3 | 16.0 | -0.3 | 1.2 | 0.7 | -2.2 | -3.9 | 3.9 | -2.0 | 3.0 | -3.1 | -4.0 | 4.0 | -3.1 | 3.2 | 1.9 | 3.7 | 4.0 | -0.5 | -0.3 | 0.3 | 0.8 |
Condit. Reinf. inactive responses | 5.0 | 6.2 | 12.9 | -0.9 | 1.7 | -0.6 | -2.2 | -3.2 | 3.2 | -2.2 | 3.0 | -3.0 | -3.6 | 3.4 | -3.1 | 3.1 | 1.5 | 3.2 | 3.1 | -1.1 | 1.5 | 0.8 | 1.7 |
Degree of sensitization stereotypy | 4.7 | 5.1 | 10.3 | -2.6 | 3.0 | -3.1 | -2.5 | 0.0 | -0.0 | -2.8 | 2.3 | -2.5 | -1.0 | 0.4 | -2.5 | 2.4 | -0.9 | 1.3 | 0.2 | -2.8 | 3.1 | 2.6 | 3.2 |
Time in open arm before self-admin | 4.2 | 4.5 | 8.3 | 2.5 | -2.8 | 2.1 | 2.0 | 0.2 | -0.2 | 2.9 | -2.7 | 2.8 | 1.3 | -0.6 | 2.7 | -2.0 | 0.7 | -1.4 | -0.5 | 2.7 | -2.6 | -2.5 | -2.9 |
Retroperitoneal fat weight | 3.8 | 12.6 | 29.0 | 5.3 | -4.7 | 4.1 | 2.7 | -2.5 | 2.5 | 4.2 | -3.3 | 2.9 | -1.4 | 2.2 | 2.5 | -1.7 | 5.1 | 1.2 | 2.6 | 5.2 | -2.4 | -5.4 | -4.3 |
Number of licking bursts | 3.8 | 4.5 | 8.4 | 2.6 | -2.8 | 1.8 | 2.4 | 0.6 | -0.6 | 2.9 | -2.6 | 2.8 | 1.2 | -0.8 | 2.7 | -2.3 | 1.3 | -1.4 | -0.6 | 2.6 | -1.7 | -2.6 | -2.7 |
Delta time in closed arm before/after self-admin | 3.3 | 3.2 | 10.3 | 2.5 | -2.2 | 2.8 | 1.0 | -1.2 | 1.2 | 1.9 | -1.7 | 1.2 | -0.5 | 1.0 | 1.1 | -0.5 | 2.0 | 0.6 | 1.2 | 2.5 | -3.2 | -2.5 | -1.8 |
Food consumed during 24 hour testing period | 3.2 | 3.8 | 7.5 | -2.3 | 2.6 | -2.5 | -2.3 | 0.1 | -0.1 | -2.5 | 2.2 | -2.2 | -0.7 | 0.2 | -2.2 | 2.1 | -1.0 | 1.1 | -0.0 | -2.4 | 2.6 | 2.3 | 2.7 |
Tail length | 3.0 | 8.9 | 22.2 | 1.5 | -0.1 | 0.8 | -1.9 | -4.4 | 4.4 | -0.6 | 1.8 | -2.1 | -4.7 | 4.6 | -2.4 | 3.0 | 4.6 | 4.6 | 4.5 | 1.1 | 0.8 | -1.6 | -0.2 |
Mean num. licks in bursts | 3.0 | 3.6 | 6.6 | -2.2 | 2.5 | -1.6 | -2.3 | -0.6 | 0.6 | -2.6 | 2.4 | -2.5 | -1.2 | 0.8 | -2.5 | 2.2 | -0.9 | 1.4 | 0.7 | -2.3 | 1.6 | 2.2 | 2.4 |
Pavlov. Cond. magazine entry latency | 3.0 | 3.4 | 6.1 | -2.1 | 2.4 | -2.0 | -2.5 | -0.3 | 0.3 | -2.5 | 2.1 | -2.3 | -1.0 | 0.6 | -2.3 | 2.2 | -0.8 | 1.4 | 0.4 | -2.2 | 1.7 | 2.1 | 2.3 |
Zn content in liver | 3.0 | 3.3 | 7.2 | -1.8 | 2.2 | -1.3 | -2.7 | -0.9 | 0.9 | -2.3 | 2.0 | -2.4 | -1.3 | 1.0 | -2.4 | 2.6 | -0.6 | 1.9 | 0.9 | -1.8 | 0.6 | 1.7 | 2.2 |
Liver weight, right | 2.9 | 4.9 | 11.3 | 2.9 | -2.6 | 3.4 | 1.4 | -2.3 | 2.3 | 2.0 | -1.1 | 1.0 | -1.5 | 2.0 | 0.9 | -0.6 | 2.7 | 1.0 | 1.9 | 2.9 | -3.0 | -2.9 | -2.7 |
Time in closed arm before self-admin | 2.9 | 3.4 | 7.4 | -2.7 | 2.4 | -2.2 | -1.0 | 1.1 | -1.1 | -2.3 | 2.0 | -1.7 | 0.2 | -0.8 | -1.5 | 0.6 | -2.0 | -0.4 | -0.9 | -2.7 | 2.3 | 2.7 | 2.4 |
Active lever presses in extinction session 6 | 2.8 | 2.7 | 6.4 | -2.4 | 2.2 | -2.1 | -1.0 | 1.1 | -1.1 | -2.0 | 1.7 | -1.4 | 0.4 | -0.8 | -1.3 | 0.9 | -1.9 | -0.4 | -0.8 | -2.4 | 1.9 | 2.5 | 2.0 |
Bone: trabecular tissue density | 2.7 | 3.8 | 8.8 | 2.4 | -2.2 | 3.0 | 1.8 | -2.2 | 2.2 | 1.7 | -0.5 | 0.8 | -1.6 | 2.0 | 0.8 | -0.9 | 2.5 | 0.6 | 2.2 | 2.3 | -1.9 | -2.3 | -2.4 |
Delta time in open arm before/after self-admin | 2.7 | 2.6 | 4.8 | -1.6 | 2.0 | -1.3 | -2.1 | -0.5 | 0.5 | -2.1 | 2.1 | -2.2 | -1.1 | 0.8 | -2.2 | 2.1 | -0.2 | 1.6 | 0.8 | -1.7 | 1.6 | 1.6 | 1.8 |
Run reversals in cocaine runway, females | 2.7 | 2.7 | 7.8 | 2.2 | -1.6 | 1.4 | 0.2 | -2.1 | 2.1 | 1.3 | -1.1 | 0.5 | -1.6 | 2.0 | 0.3 | 0.2 | 2.8 | 1.7 | 1.9 | 2.1 | -0.6 | -2.4 | -1.0 |
Std. dev. time between licks in bursts | 2.6 | 3.1 | 9.2 | 0.7 | -0.1 | 1.4 | -0.8 | -2.8 | 2.8 | -0.5 | 1.5 | -1.4 | -2.6 | 2.7 | -1.4 | 1.7 | 1.7 | 2.3 | 3.0 | 0.6 | -0.9 | -0.7 | -0.5 |
Total sessions with >9 infusions | 2.6 | 2.8 | 6.4 | -2.0 | 2.3 | -2.1 | -2.2 | 0.3 | -0.3 | -2.2 | 1.5 | -2.0 | -0.6 | 0.0 | -2.0 | 1.6 | -0.8 | 1.1 | -0.3 | -2.1 | 1.8 | 1.9 | 2.5 |
Distance moved, locomotor task time 2 | 2.6 | 3.0 | 6.1 | -1.2 | 1.6 | -0.9 | -1.8 | -1.7 | 1.7 | -1.8 | 2.5 | -2.2 | -1.9 | 1.8 | -2.2 | 2.4 | 0.6 | 2.1 | 2.0 | -1.2 | 1.3 | 1.0 | 1.1 |
Degree of sensitization distance | 2.5 | 2.5 | 5.6 | 1.8 | -1.6 | 2.4 | 0.9 | -2.0 | 2.0 | 1.2 | -0.3 | 0.4 | -1.5 | 1.8 | 0.3 | -0.2 | 2.1 | 0.9 | 1.9 | 1.9 | -1.8 | -1.9 | -1.8 |
Pavlov. Cond. magazine entry number | 2.5 | 3.1 | 5.5 | 1.5 | -2.0 | 1.7 | 2.3 | 0.9 | -0.9 | 2.1 | -2.0 | 2.3 | 1.5 | -1.2 | 2.3 | -2.3 | 0.0 | -1.9 | -1.0 | 1.7 | -1.8 | -1.5 | -2.2 |
Bone: elastic work | 2.5 | 3.3 | 7.7 | 0.4 | -0.9 | -0.7 | 1.2 | 2.6 | -2.6 | 1.4 | -2.3 | 2.1 | 2.7 | -2.6 | 2.1 | -2.0 | -1.1 | -2.2 | -2.8 | 0.5 | -0.3 | -0.4 | -0.5 |
Time to tail flick, vehicle, after self-admin | 2.5 | 2.7 | 5.2 | -2.1 | 2.2 | -2.1 | -1.8 | -0.0 | 0.0 | -2.1 | 1.7 | -1.8 | -0.6 | 0.2 | -1.8 | 1.5 | -1.0 | 0.8 | -0.3 | -2.1 | 2.3 | 2.1 | 2.0 |
Se content in liver | 2.5 | 3.0 | 5.6 | 1.3 | -1.8 | 0.7 | 2.1 | 1.5 | -1.5 | 2.1 | -2.3 | 2.4 | 1.9 | -1.7 | 2.4 | -2.4 | -0.2 | -2.0 | -1.5 | 1.4 | -0.8 | -1.3 | -1.8 |
Indifference point 0 sec | 2.4 | 4.0 | 7.7 | -2.2 | 2.5 | -1.0 | -2.6 | -0.9 | 0.9 | -2.7 | 2.6 | -2.8 | -1.3 | 1.1 | -2.7 | 2.7 | -1.0 | 1.7 | 0.7 | -2.2 | 1.3 | 2.1 | 2.1 |
Delay discounting time to switch 0 sec | 2.4 | 3.6 | 6.7 | 1.6 | -2.1 | 1.0 | 2.4 | 1.3 | -1.3 | 2.3 | -2.3 | 2.6 | 1.9 | -1.5 | 2.6 | -2.6 | -0.0 | -2.2 | -0.9 | 1.7 | -1.8 | -1.5 | -2.3 |
Conditioned locomotion | 2.4 | 2.9 | 6.0 | -2.2 | 2.3 | -2.0 | -1.6 | 0.4 | -0.4 | -2.2 | 2.2 | -1.8 | 0.1 | -0.3 | -1.7 | 1.5 | -1.8 | 0.3 | -0.3 | -2.4 | 1.7 | 2.4 | 2.1 |
Stereotopy head waving duration, day 7 | 2.4 | 3.0 | 6.5 | -1.8 | 2.2 | -2.5 | -2.0 | -0.1 | 0.1 | -2.1 | 1.6 | -1.9 | -0.9 | 0.4 | -1.9 | 2.0 | -0.4 | 1.2 | 0.2 | -2.1 | 2.5 | 1.8 | 2.6 |
Stereotopy head waving bouts, day 7 | 2.3 | 2.6 | 6.3 | -1.9 | 2.1 | -2.4 | -1.6 | 0.1 | -0.1 | -2.0 | 1.5 | -1.7 | -0.7 | 0.2 | -1.7 | 1.6 | -0.6 | 0.9 | 0.0 | -2.0 | 2.5 | 1.8 | 2.5 |
Latency to leave start box in cocaine runway | 2.3 | 2.5 | 7.0 | 2.0 | -2.0 | 1.1 | 1.3 | 0.6 | -0.6 | 2.1 | -2.7 | 2.0 | 0.7 | -0.6 | 1.8 | -1.6 | 1.4 | -0.5 | -0.6 | 2.0 | -1.6 | -2.1 | -1.5 |
Conditioned reinforcement - actives | 2.2 | 2.1 | 4.3 | -2.1 | 2.0 | -1.0 | -1.7 | 0.1 | -0.1 | -2.0 | 1.8 | -1.8 | -0.2 | -0.0 | -1.7 | 1.6 | -1.6 | 0.5 | -0.1 | -1.9 | 0.7 | 2.0 | 1.8 |
Pavlov. Cond. magazine entry latency | 2.2 | 2.8 | 5.1 | -1.2 | 1.7 | -1.2 | -2.1 | -1.2 | 1.2 | -2.0 | 2.1 | -2.2 | -1.7 | 1.4 | -2.3 | 2.3 | 0.3 | 2.0 | 1.2 | -1.4 | 1.3 | 1.2 | 1.8 |
Light reinforcement 1 | 2.1 | 3.9 | 7.7 | 1.7 | -2.2 | 1.6 | 2.1 | 1.4 | -1.4 | 2.4 | -2.8 | 2.6 | 1.9 | -1.5 | 2.6 | -2.3 | 0.1 | -1.9 | -1.3 | 1.9 | -2.1 | -1.8 | -2.2 |
Cocaine response before conditioning | 2.1 | 2.5 | 6.6 | -2.0 | 2.1 | -2.6 | -1.7 | 1.1 | -1.1 | -1.8 | 0.9 | -1.2 | 0.6 | -0.9 | -1.2 | 1.2 | -1.7 | 0.1 | -1.0 | -2.1 | 2.0 | 2.0 | 2.3 |
Short access day 1 locomotion | 2.1 | 2.3 | 4.1 | -1.9 | 2.0 | -2.0 | -1.8 | 1.1 | -1.1 | -1.8 | 1.0 | -1.3 | 0.5 | -0.9 | -1.3 | 1.0 | -1.8 | 0.1 | -1.2 | -2.0 | 1.3 | 2.0 | 1.9 |
Pavlov. Cond. index score | 2.1 | 2.7 | 5.3 | -1.1 | 1.7 | -1.4 | -2.1 | -1.2 | 1.2 | -1.9 | 1.9 | -2.1 | -1.6 | 1.4 | -2.2 | 2.3 | 0.3 | 2.0 | 1.2 | -1.3 | 1.5 | 1.1 | 1.9 |
Pavlov. Cond. latency score | 2.1 | 2.7 | 5.1 | -1.2 | 1.7 | -1.2 | -2.0 | -1.2 | 1.2 | -1.9 | 2.0 | -2.1 | -1.7 | 1.4 | -2.2 | 2.3 | 0.2 | 1.9 | 1.3 | -1.4 | 1.3 | 1.2 | 1.8 |
Diff in mean of infusions in LGA sessions | 2.1 | 2.3 | 4.6 | 2.0 | -2.0 | 1.0 | 2.1 | -0.1 | 0.1 | 2.1 | -1.8 | 2.0 | 0.2 | -0.0 | 2.0 | -2.0 | 1.5 | -0.9 | 0.2 | 1.8 | 0.2 | -1.9 | -1.9 |
Rest time, locomotor task time 2 | 2.1 | 2.5 | 5.1 | 1.2 | -1.7 | 1.2 | 1.9 | 1.1 | -1.1 | 1.8 | -2.2 | 2.0 | 1.3 | -1.2 | 2.1 | -2.3 | 0.0 | -1.7 | -1.4 | 1.3 | -1.4 | -1.2 | -1.5 |
Latency to leave start box in cocaine runway, F | 2.1 | 2.3 | 5.4 | 2.2 | -2.1 | 1.4 | 1.2 | -0.4 | 0.4 | 2.0 | -2.1 | 1.6 | -0.0 | 0.3 | 1.5 | -1.1 | 1.9 | 0.1 | 0.3 | 2.2 | -1.5 | -2.3 | -1.6 |
Length with tail | 2.0 | 7.5 | 19.8 | 1.8 | -0.7 | 1.7 | -0.7 | -4.2 | 4.2 | -0.0 | 1.6 | -1.5 | -4.3 | 4.3 | -1.7 | 1.9 | 4.3 | 3.7 | 4.5 | 1.5 | 0.3 | -1.8 | -0.9 |
Delay discounting water rate 0 sec | 2.0 | 3.2 | 6.2 | -2.0 | 2.2 | -1.0 | -2.3 | -0.8 | 0.8 | -2.4 | 2.3 | -2.5 | -1.3 | 1.0 | -2.5 | 2.3 | -0.7 | 1.6 | 0.4 | -2.0 | 1.1 | 1.9 | 2.1 |
Saline control response | 2.0 | 2.6 | 5.3 | -0.7 | 1.2 | -0.5 | -1.4 | -2.0 | 2.0 | -1.5 | 2.0 | -2.0 | -2.3 | 2.1 | -2.0 | 1.9 | 0.8 | 2.0 | 1.6 | -0.9 | 1.3 | 0.7 | 1.3 |
Short access day 1 total infusions | 2.0 | 2.1 | 4.2 | -1.2 | 1.6 | -0.8 | -2.0 | -0.8 | 0.8 | -1.9 | 1.9 | -2.0 | -1.4 | 1.0 | -2.0 | 1.8 | -0.0 | 1.6 | 1.0 | -1.4 | 1.2 | 1.2 | 1.6 |
Context. condit. distance diff. score | 2.0 | 2.5 | 4.4 | -2.0 | 2.1 | -1.6 | -1.7 | -0.1 | 0.1 | -2.1 | 1.9 | -1.9 | -0.7 | 0.3 | -1.8 | 1.5 | -0.9 | 0.8 | 0.1 | -2.1 | 1.9 | 2.0 | 2.0 |
Bone: elastic displacement | 2.0 | 2.2 | 4.0 | 0.7 | -1.1 | -0.3 | 1.5 | 1.8 | -1.8 | 1.5 | -2.0 | 1.9 | 2.0 | -1.9 | 2.0 | -2.0 | -0.5 | -1.9 | -1.9 | 0.7 | 0.2 | -0.7 | -0.8 |
Delta distance traveled before/after self-admin | 2.0 | 2.1 | 5.5 | -1.9 | 1.8 | -1.4 | -0.8 | -0.7 | 0.7 | -1.9 | 2.2 | -1.7 | -1.3 | 0.9 | -1.6 | 1.0 | -0.4 | 0.6 | 0.9 | -1.9 | 2.4 | 1.7 | 1.2 |
Delta ambulatory time before/after self-admin | 2.0 | 2.1 | 5.1 | -2.1 | 2.0 | -1.7 | -0.9 | 0.0 | -0.0 | -1.9 | 2.0 | -1.6 | -0.7 | 0.2 | -1.5 | 0.9 | -0.9 | 0.2 | 0.2 | -2.1 | 2.3 | 2.0 | 1.4 |
Locomotion in novel chamber post-restriction | 2.0 | 2.3 | 5.4 | -1.9 | 2.1 | -2.3 | -1.8 | 0.6 | -0.6 | -1.9 | 1.1 | -1.5 | 0.2 | -0.5 | -1.5 | 1.4 | -1.2 | 0.5 | -0.7 | -2.0 | 1.7 | 1.9 | 2.1 |
Delay discounting total patch changes 0 sec | 1.9 | 3.1 | 6.0 | -1.9 | 2.2 | -0.9 | -2.3 | -0.8 | 0.8 | -2.4 | 2.3 | -2.4 | -1.2 | 1.0 | -2.4 | 2.4 | -0.9 | 1.6 | 0.6 | -1.8 | 1.3 | 1.8 | 1.9 |
Reaction time num false alarms | 1.9 | 2.7 | 7.1 | 1.9 | -2.1 | 2.7 | 2.0 | -0.6 | 0.6 | 2.0 | -1.2 | 1.6 | 0.2 | 0.3 | 1.7 | -1.6 | 0.9 | -0.8 | 0.5 | 2.0 | -2.2 | -1.9 | -2.4 |
Locomotion distance, session 8 | 1.8 | 2.7 | 4.8 | -1.9 | 2.1 | -1.6 | -1.8 | -0.5 | 0.5 | -2.2 | 2.2 | -2.1 | -1.2 | 0.8 | -2.1 | 1.8 | -0.5 | 1.1 | 0.7 | -2.0 | 1.8 | 1.9 | 2.0 |
Locomotion velocity, hab. session 2 | 1.8 | 2.4 | 6.0 | 1.3 | -1.0 | 1.9 | 0.6 | -2.4 | 2.4 | 0.5 | 0.7 | -0.3 | -2.2 | 2.3 | -0.4 | 0.4 | 2.2 | 1.4 | 2.4 | 1.2 | -0.7 | -1.4 | -1.3 |
Bone: cortical apparent density | 1.8 | 2.3 | 5.0 | 2.0 | -2.0 | 2.2 | 1.8 | -0.6 | 0.6 | 1.9 | -1.3 | 1.5 | -0.1 | 0.4 | 1.5 | -1.5 | 1.3 | -0.4 | 0.5 | 2.0 | -1.7 | -1.9 | -2.2 |
Co content in liver | 1.8 | 2.1 | 4.9 | -0.3 | 0.7 | 0.1 | -1.1 | -2.1 | 2.1 | -1.1 | 1.7 | -1.6 | -2.2 | 2.1 | -1.7 | 1.6 | 1.2 | 1.9 | 2.1 | -0.4 | 0.5 | 0.2 | 0.6 |
Cocaine response after cond. corrected | 1.7 | 1.9 | 3.4 | 1.8 | -1.8 | 1.4 | 1.3 | 0.2 | -0.2 | 1.8 | -1.8 | 1.6 | 0.6 | -0.3 | 1.5 | -1.3 | 1.1 | -0.5 | -0.6 | 1.8 | -1.6 | -1.8 | -1.7 |
Total zone transitions, hab. session 2 | 1.7 | 2.2 | 9.6 | -1.7 | 1.8 | -2.3 | -1.1 | 0.2 | -0.2 | -1.7 | 1.5 | -1.4 | -0.6 | 0.1 | -1.3 | 1.1 | -0.5 | 0.4 | -0.1 | -1.9 | 3.1 | 1.7 | 2.0 |
Pavlov. Cond. lever-magazine prob. diff. | 1.7 | 2.1 | 4.2 | -1.1 | 1.6 | -1.4 | -1.9 | -0.9 | 0.9 | -1.7 | 1.6 | -1.8 | -1.4 | 1.1 | -1.9 | 2.0 | 0.2 | 1.7 | 0.9 | -1.2 | 1.5 | 1.1 | 1.7 |
Bone: cortical tissue density | 1.7 | 2.3 | 4.9 | 2.0 | -2.0 | 2.2 | 1.8 | -0.6 | 0.6 | 1.8 | -1.3 | 1.5 | -0.0 | 0.4 | 1.5 | -1.5 | 1.2 | -0.5 | 0.4 | 2.0 | -1.7 | -1.8 | -2.2 |
Delay discounting water rate 12 sec | 1.6 | 2.4 | 4.6 | -2.1 | 2.1 | -1.2 | -2.0 | -0.3 | 0.3 | -2.1 | 1.8 | -2.0 | -0.6 | 0.4 | -1.9 | 1.5 | -1.4 | 0.9 | 0.0 | -1.9 | 0.9 | 1.9 | 2.0 |
Reaction time premature initiation rate | 1.6 | 2.1 | 5.8 | 0.4 | 0.2 | 0.5 | -1.3 | -2.1 | 2.1 | -0.6 | 0.9 | -1.3 | -2.1 | 2.2 | -1.4 | 1.9 | 1.6 | 2.4 | 2.2 | 0.4 | 0.1 | -0.6 | 0.3 |
Social responses | 1.6 | 2.1 | 6.1 | 1.3 | -1.3 | 2.5 | 0.7 | -2.1 | 2.1 | 0.8 | 0.1 | 0.0 | -1.6 | 1.9 | 0.0 | -0.1 | 1.7 | 0.9 | 2.0 | 1.5 | -1.6 | -1.5 | -1.4 |
Cocaine induced anxiety | 1.6 | 1.8 | 4.0 | 1.3 | -1.7 | 1.6 | 2.0 | 0.3 | -0.3 | 1.7 | -1.3 | 1.7 | 1.0 | -0.6 | 1.8 | -1.9 | -0.0 | -1.5 | -0.2 | 1.4 | -0.6 | -1.2 | -1.8 |
One hour access (shock baseline) | 1.6 | 1.8 | 4.2 | -0.7 | 1.2 | -0.2 | -1.3 | -1.4 | 1.4 | -1.5 | 2.0 | -1.8 | -1.6 | 1.4 | -1.8 | 1.8 | 0.5 | 1.7 | 1.4 | -0.9 | 0.8 | 0.8 | 1.2 |
Delta time to tail flick, vehicle, before/after SA | 1.6 | 1.6 | 3.4 | -1.6 | 1.7 | -1.4 | -1.8 | 0.3 | -0.3 | -1.6 | 0.9 | -1.3 | 0.2 | -0.2 | -1.4 | 1.2 | -1.4 | 0.6 | -0.5 | -1.5 | 1.3 | 1.5 | 1.8 |
Time >=10cm from walls, locomotor time 2 | 1.6 | 1.6 | 3.5 | -1.0 | 1.1 | 0.2 | -1.1 | -1.5 | 1.5 | -1.5 | 1.8 | -1.9 | -1.5 | 1.5 | -1.8 | 1.4 | 0.3 | 1.4 | 1.4 | -1.0 | 0.2 | 0.9 | 0.9 |
Bouts of movement, locomotor time 2 | 1.6 | 1.7 | 4.0 | 0.7 | -0.4 | 2.0 | -0.2 | -1.9 | 1.9 | -0.1 | 0.9 | -0.8 | -2.0 | 2.0 | -0.7 | 1.0 | 1.2 | 1.3 | 1.6 | 0.7 | -2.0 | -0.8 | -0.7 |
Liver weight, left | 1.5 | 2.5 | 7.7 | 1.8 | -1.7 | 2.8 | 0.9 | -1.6 | 1.6 | 1.3 | -0.6 | 0.6 | -0.8 | 1.3 | 0.6 | -0.3 | 1.5 | 0.6 | 1.6 | 2.0 | -2.8 | -1.9 | -2.0 |
Reaction time false alarm rate | 1.5 | 2.1 | 5.9 | 1.8 | -1.9 | 2.4 | 1.4 | -0.7 | 0.7 | 1.7 | -1.2 | 1.3 | 0.0 | 0.4 | 1.3 | -1.0 | 0.9 | -0.4 | 0.6 | 1.9 | -2.1 | -1.8 | -2.0 |
Social time | 1.5 | 1.9 | 5.6 | 1.1 | -1.5 | 1.0 | 2.2 | 0.9 | -0.9 | 1.6 | -1.5 | 1.8 | 1.2 | -1.0 | 1.9 | -2.4 | -0.1 | -1.8 | -0.9 | 1.1 | -0.0 | -0.9 | -1.5 |
One hour access (0.3 mA shock) | 1.5 | 1.8 | 3.6 | -1.2 | 1.5 | -0.4 | -1.7 | -0.8 | 0.8 | -1.7 | 1.8 | -1.9 | -1.0 | 0.9 | -1.9 | 1.9 | -0.3 | 1.4 | 0.9 | -1.2 | 0.2 | 1.2 | 1.7 |
Locomotion distance, session 3 | 1.5 | 1.6 | 3.1 | -1.7 | 1.7 | -1.7 | -1.2 | 0.9 | -0.9 | -1.4 | 1.1 | -1.0 | 0.4 | -0.7 | -0.9 | 0.8 | -1.4 | -0.1 | -0.7 | -1.7 | 1.8 | 1.7 | 1.7 |
Total locomotion distance, hab. session 1 | 1.5 | 2.1 | 4.5 | 1.8 | -1.7 | 2.1 | 1.1 | -1.6 | 1.6 | 1.3 | -0.4 | 0.7 | -1.1 | 1.4 | 0.6 | -0.5 | 1.8 | 0.6 | 1.6 | 1.8 | -1.5 | -2.0 | -1.8 |
Total locomotion distance, hab. session 2 | 1.5 | 2.0 | 5.3 | 1.0 | -0.8 | 1.7 | 0.4 | -2.3 | 2.3 | 0.3 | 0.9 | -0.5 | -2.1 | 2.2 | -0.5 | 0.5 | 1.9 | 1.3 | 2.3 | 1.0 | -0.7 | -1.1 | -1.0 |
Bone: maximum diameter | 1.5 | 2.7 | 5.4 | -0.7 | 1.2 | -0.5 | -1.6 | -1.9 | 1.9 | -1.6 | 1.9 | -2.0 | -2.3 | 2.1 | -2.1 | 2.1 | 1.1 | 2.2 | 1.7 | -0.8 | 1.0 | 0.6 | 1.4 |
Time >=10cm from walls, locomotor time 1 | 1.5 | 1.5 | 2.9 | -1.7 | 1.6 | -0.6 | -1.2 | -0.1 | 0.1 | -1.7 | 1.7 | -1.6 | -0.3 | 0.2 | -1.5 | 1.1 | -1.4 | 0.5 | 0.4 | -1.5 | 0.9 | 1.6 | 1.4 |
Mn content in liver | 1.5 | 1.7 | 3.7 | 0.1 | -0.6 | 0.3 | 1.2 | 1.8 | -1.8 | 0.9 | -1.3 | 1.4 | 1.9 | -1.8 | 1.5 | -1.6 | -1.2 | -1.9 | -1.8 | 0.2 | -0.4 | -0.0 | -0.6 |
Tibia length | 1.4 | 4.0 | 7.9 | -2.7 | 2.8 | -2.0 | -2.0 | 0.2 | -0.2 | -2.8 | 2.8 | -2.5 | -0.6 | 0.1 | -2.3 | 1.8 | -1.7 | 0.6 | 0.3 | -2.8 | 1.2 | 2.8 | 2.4 |
Locomotor testing distance | 1.4 | 2.3 | 4.8 | -1.2 | 1.4 | -0.4 | -1.4 | -1.4 | 1.4 | -1.7 | 2.2 | -2.1 | -1.9 | 1.6 | -2.0 | 2.0 | 0.3 | 1.7 | 1.3 | -1.2 | 0.5 | 1.1 | 1.4 |
Intermittent access day 15 total infusions | 1.4 | 1.6 | 3.6 | -1.5 | 1.6 | -1.0 | -1.4 | -0.4 | 0.4 | -1.7 | 1.5 | -1.7 | -0.7 | 0.5 | -1.7 | 1.4 | -0.4 | 1.0 | 0.4 | -1.5 | 0.6 | 1.4 | 1.9 |
Bone: tissue strength | 1.4 | 1.3 | 3.5 | -0.9 | 0.5 | -1.0 | 0.2 | 1.8 | -1.8 | -0.1 | -0.4 | 0.5 | 1.7 | -1.8 | 0.6 | -0.8 | -1.5 | -1.5 | -1.9 | -0.8 | 0.6 | 0.9 | 0.6 |
Indifference point function ln k | 1.3 | 1.9 | 4.7 | -2.1 | 1.8 | -1.6 | -1.1 | 1.0 | -1.0 | -1.7 | 1.4 | -1.2 | 0.6 | -0.9 | -1.0 | 0.7 | -2.1 | -0.4 | -0.7 | -2.0 | 0.8 | 2.2 | 1.2 |
Indifference point function log k | 1.3 | 1.9 | 4.7 | -2.1 | 1.8 | -1.6 | -1.1 | 1.0 | -1.0 | -1.7 | 1.4 | -1.2 | 0.6 | -0.9 | -1.0 | 0.7 | -2.1 | -0.4 | -0.7 | -2.0 | 0.8 | 2.2 | 1.2 |
Delay discounting total patch changes 18 sec | 1.3 | 1.7 | 4.5 | -0.9 | 1.3 | -0.4 | -1.6 | -1.2 | 1.2 | -1.5 | 1.4 | -1.8 | -1.2 | 1.2 | -1.8 | 2.1 | -0.2 | 1.5 | 0.6 | -1.0 | 0.3 | 1.0 | 1.5 |
Condit. Reinf. active-inactive response ratio | 1.3 | 1.4 | 2.5 | -1.0 | 1.3 | -1.2 | -1.6 | -0.5 | 0.5 | -1.4 | 1.2 | -1.4 | -1.0 | 0.7 | -1.5 | 1.6 | 0.1 | 1.3 | 0.4 | -1.1 | 1.5 | 1.0 | 1.5 |
Intermittent access day 15 total locomotion | 1.3 | 1.4 | 3.7 | -1.2 | 1.5 | -1.7 | -1.4 | 0.6 | -0.6 | -1.4 | 0.9 | -1.1 | 0.1 | -0.4 | -1.1 | 1.1 | -0.6 | 0.5 | -0.5 | -1.5 | 1.8 | 1.4 | 1.9 |
Lifetime Intake | 1.3 | 1.5 | 3.0 | -1.2 | 1.5 | -0.9 | -1.5 | -0.4 | 0.4 | -1.6 | 1.5 | -1.7 | -0.9 | 0.6 | -1.7 | 1.5 | -0.1 | 1.2 | 0.5 | -1.3 | 0.9 | 1.1 | 1.7 |
Incentive Sensitization - Responses | 1.3 | 1.3 | 3.5 | -0.5 | 1.0 | -0.3 | -1.6 | -0.8 | 0.8 | -1.3 | 1.2 | -1.6 | -1.3 | 1.0 | -1.6 | 1.9 | 0.6 | 1.7 | 0.9 | -0.7 | 0.4 | 0.6 | 1.2 |
Time in familiar zone, hab. session 2 | 1.3 | 1.4 | 2.9 | -0.7 | 1.0 | 0.1 | -1.3 | -1.3 | 1.3 | -1.3 | 1.7 | -1.6 | -1.3 | 1.3 | -1.6 | 1.5 | -0.0 | 1.4 | 1.3 | -0.7 | -0.4 | 0.8 | 0.8 |
Bone: endosteal perimeter | 1.3 | 2.6 | 6.1 | -0.5 | 1.1 | -0.4 | -1.9 | -1.8 | 1.8 | -1.4 | 1.7 | -2.0 | -2.2 | 2.0 | -2.1 | 2.4 | 1.3 | 2.5 | 1.6 | -0.6 | 0.6 | 0.4 | 1.2 |
Bone: minimum diameter | 1.3 | 2.4 | 6.1 | 1.0 | -0.4 | 1.2 | -0.4 | -2.4 | 2.4 | -0.0 | 0.8 | -0.9 | -2.4 | 2.5 | -1.0 | 1.2 | 2.4 | 2.1 | 2.4 | 0.9 | -0.3 | -1.0 | -0.5 |
Seeking ratio, punishment vs. effort | 1.3 | 1.6 | 4.0 | 0.7 | -0.1 | 0.8 | -0.7 | -2.0 | 2.0 | -0.3 | 1.2 | -1.0 | -1.7 | 1.9 | -1.0 | 1.2 | 1.6 | 1.8 | 2.0 | 0.5 | -0.0 | -0.6 | -0.5 |
Delay discounting total patch changes 12 sec | 1.2 | 1.6 | 3.7 | 0.1 | 0.4 | 0.8 | -1.0 | -1.9 | 1.9 | -0.8 | 1.2 | -1.4 | -1.9 | 1.9 | -1.4 | 1.7 | 1.1 | 1.8 | 1.4 | -0.0 | 0.0 | -0.1 | 0.5 |
Delay discounting water rate 18 sec | 1.2 | 1.5 | 2.5 | -0.9 | 1.2 | -0.9 | -1.5 | -1.0 | 1.0 | -1.3 | 1.4 | -1.5 | -1.5 | 1.2 | -1.6 | 1.3 | 0.4 | 1.6 | 0.9 | -0.9 | 1.4 | 0.8 | 1.6 |
Median of all reaction times | 1.2 | 1.7 | 4.5 | 1.4 | -1.7 | 2.1 | 1.6 | -0.3 | 0.3 | 1.5 | -0.7 | 1.2 | 0.3 | 0.1 | 1.3 | -1.3 | 0.5 | -0.7 | 0.3 | 1.6 | -1.9 | -1.4 | -2.1 |
Intermittent access terminal intake (last 3 days) | 1.2 | 1.3 | 2.7 | -1.1 | 1.4 | -0.6 | -1.2 | -0.7 | 0.7 | -1.5 | 1.6 | -1.6 | -1.0 | 0.8 | -1.6 | 1.5 | -0.0 | 1.1 | 0.7 | -1.2 | 0.2 | 1.1 | 1.6 |
Short access day 10 total infusions | 1.2 | 1.3 | 2.7 | -0.6 | 1.1 | -0.9 | -1.5 | -0.7 | 0.7 | -1.3 | 1.1 | -1.5 | -1.2 | 0.9 | -1.5 | 1.6 | 0.6 | 1.5 | 0.8 | -0.9 | 1.1 | 0.6 | 1.5 |
Bone: periosteal perimeter | 1.2 | 1.9 | 3.9 | -0.5 | 0.9 | -0.2 | -1.4 | -1.7 | 1.7 | -1.2 | 1.6 | -1.7 | -2.0 | 1.8 | -1.7 | 1.8 | 1.1 | 1.9 | 1.5 | -0.5 | 0.6 | 0.4 | 1.0 |
Distance traveled before self-admin | 1.2 | 1.3 | 2.2 | 1.3 | -1.5 | 1.3 | 1.4 | -0.0 | 0.0 | 1.5 | -1.2 | 1.4 | 0.5 | -0.2 | 1.4 | -1.2 | 0.4 | -0.8 | -0.1 | 1.4 | -1.5 | -1.2 | -1.4 |
Time to tail flick, test, after self-admin | 1.2 | 1.2 | 3.6 | 0.6 | -0.2 | 0.6 | -0.4 | -1.6 | 1.6 | -0.1 | 0.5 | -0.7 | -1.8 | 1.7 | -0.8 | 0.9 | 1.9 | 1.6 | 1.6 | 0.5 | -0.2 | -0.7 | -0.1 |
Total resting periods, locomotor time 2 | 1.2 | 1.3 | 4.5 | 0.9 | -0.6 | 2.0 | 0.1 | -1.6 | 1.6 | 0.3 | 0.3 | -0.3 | -1.6 | 1.6 | -0.3 | 0.6 | 1.1 | 0.9 | 1.1 | 0.8 | -2.1 | -0.9 | -0.9 |
Vertical activity count, locomotor time 2 | 1.2 | 1.4 | 3.3 | -0.3 | 0.5 | 0.2 | -1.1 | -1.6 | 1.6 | -0.9 | 1.4 | -1.4 | -1.6 | 1.6 | -1.4 | 1.5 | 0.7 | 1.6 | 1.8 | -0.2 | 0.5 | 0.2 | 0.0 |
Delay discounting total patch changes 24 sec | 1.1 | 1.3 | 3.1 | -0.1 | 0.4 | 0.7 | -1.0 | -1.8 | 1.8 | -0.8 | 1.0 | -1.3 | -1.7 | 1.8 | -1.4 | 1.4 | 0.9 | 1.7 | 1.2 | -0.1 | -0.1 | -0.1 | 0.7 |
Delay discounting water rate 24 sec | 1.1 | 1.5 | 3.5 | -1.8 | 1.6 | -1.1 | -1.1 | 0.5 | -0.5 | -1.6 | 1.3 | -1.2 | 0.3 | -0.5 | -1.1 | 0.6 | -1.9 | -0.1 | -0.7 | -1.7 | 0.6 | 1.8 | 1.5 |
Intermittent access day 1 total infusions | 1.1 | 1.2 | 2.5 | -1.0 | 1.3 | -0.7 | -1.3 | -0.5 | 0.5 | -1.4 | 1.4 | -1.6 | -0.9 | 0.7 | -1.6 | 1.4 | 0.0 | 1.1 | 0.6 | -1.1 | 0.7 | 1.0 | 1.5 |
Incentive Sensitization - Breakpoint | 1.1 | 1.2 | 3.1 | -0.6 | 1.1 | -0.4 | -1.5 | -0.6 | 0.6 | -1.3 | 1.2 | -1.5 | -1.1 | 0.8 | -1.5 | 1.8 | 0.4 | 1.5 | 0.7 | -0.8 | 0.4 | 0.7 | 1.3 |
Locomotion velocity, NPP test | 1.1 | 1.5 | 3.1 | 1.6 | -1.6 | 1.7 | 1.1 | -1.2 | 1.2 | 1.3 | -0.7 | 0.8 | -0.6 | 1.0 | 0.8 | -0.5 | 1.5 | 0.3 | 1.0 | 1.7 | -1.4 | -1.7 | -1.5 |
Pavlov. Cond. change in total contacts | 1.1 | 1.2 | 2.2 | -0.8 | 1.1 | -0.7 | -1.4 | -0.8 | 0.8 | -1.3 | 1.3 | -1.4 | -1.2 | 1.0 | -1.5 | 1.5 | 0.2 | 1.3 | 0.7 | -0.9 | 0.8 | 0.8 | 1.3 |
Ambulatory time before self-admin | 1.1 | 1.1 | 2.0 | 1.0 | -1.3 | 1.0 | 1.3 | 0.4 | -0.4 | 1.4 | -1.2 | 1.4 | 0.9 | -0.6 | 1.4 | -1.2 | 0.1 | -1.1 | -0.5 | 1.1 | -1.4 | -0.9 | -1.2 |
Intraocular pressure | 1.0 | 1.5 | 3.9 | -0.9 | 0.9 | -2.0 | -0.9 | 1.7 | -1.7 | -0.5 | -0.7 | 0.2 | 1.6 | -1.7 | 0.1 | 0.2 | -1.6 | -0.7 | -2.0 | -0.9 | 0.6 | 1.0 | 1.4 |
Locomotor testing rearing | 1.0 | 1.5 | 4.4 | 0.3 | 0.1 | 0.4 | -0.5 | -1.9 | 1.9 | -0.5 | 1.2 | -1.1 | -2.1 | 2.0 | -1.1 | 1.2 | 1.6 | 1.6 | 1.7 | 0.1 | -0.1 | -0.3 | 0.2 |
Light reinforcement 2 | 1.0 | 1.3 | 3.9 | -0.1 | -0.1 | -1.2 | 0.4 | 2.0 | -2.0 | 0.5 | -1.4 | 1.1 | 1.7 | -1.9 | 1.0 | -0.8 | -0.7 | -1.2 | -1.6 | -0.1 | 1.0 | 0.1 | 0.2 |
Reaction time num false alarms AUC | 1.0 | 1.5 | 5.1 | 1.3 | -1.5 | 2.2 | 1.5 | -0.4 | 0.4 | 1.4 | -0.8 | 1.2 | 0.3 | 0.1 | 1.2 | -1.2 | 0.2 | -0.8 | 0.3 | 1.4 | -1.8 | -1.2 | -1.8 |
Intermittent access total infusions | 1.0 | 1.1 | 2.2 | -1.0 | 1.2 | -0.7 | -1.3 | -0.5 | 0.5 | -1.4 | 1.3 | -1.5 | -0.8 | 0.6 | -1.5 | 1.4 | -0.0 | 1.1 | 0.6 | -1.1 | 0.5 | 0.9 | 1.5 |
Short access total infusions | 1.0 | 1.1 | 2.3 | -0.8 | 1.2 | -0.8 | -1.5 | -0.4 | 0.4 | -1.3 | 1.1 | -1.5 | -1.0 | 0.7 | -1.5 | 1.3 | 0.2 | 1.3 | 0.6 | -1.0 | 0.7 | 0.8 | 1.4 |
Locomotion velocity, hab. session 1 | 1.0 | 1.5 | 3.3 | 1.3 | -1.3 | 1.8 | 0.9 | -1.5 | 1.5 | 1.0 | -0.1 | 0.4 | -1.1 | 1.3 | 0.4 | -0.3 | 1.5 | 0.5 | 1.5 | 1.4 | -1.5 | -1.5 | -1.5 |
Total locomotion distance, NPP test | 1.0 | 1.4 | 2.9 | 1.4 | -1.3 | 1.7 | 0.8 | -1.4 | 1.4 | 1.0 | -0.3 | 0.4 | -0.9 | 1.3 | 0.4 | -0.2 | 1.4 | 0.6 | 1.3 | 1.5 | -1.4 | -1.5 | -1.3 |
Bone: cortical porosity | 1.0 | 1.0 | 2.4 | -1.5 | 1.4 | -1.2 | -0.9 | 0.4 | -0.4 | -1.3 | 1.1 | -1.0 | 0.2 | -0.4 | -0.9 | 0.7 | -1.3 | -0.1 | -0.2 | -1.5 | 0.7 | 1.5 | 1.2 |
Bone: endosteal estimation | 1.0 | 2.1 | 5.5 | -0.1 | 0.7 | 0.0 | -1.7 | -1.8 | 1.8 | -1.1 | 1.3 | -1.7 | -2.0 | 1.9 | -1.8 | 2.1 | 1.3 | 2.3 | 1.6 | -0.2 | -0.0 | 0.1 | 0.8 |
Delay disc. indifference point, 24s delay | 1.0 | 0.9 | 3.9 | 0.7 | -1.1 | 1.6 | 1.3 | 0.3 | -0.3 | 1.0 | -0.6 | 1.0 | 0.6 | -0.5 | 1.0 | -1.0 | -0.1 | -1.0 | -0.2 | 0.8 | -2.0 | -0.9 | -1.2 |
Delay disc. indifference point, 4s delay | 1.0 | 1.0 | 2.3 | 0.3 | 0.1 | 0.4 | -0.6 | -1.5 | 1.5 | -0.3 | 0.9 | -0.8 | -1.4 | 1.5 | -0.9 | 1.2 | 1.4 | 1.5 | 1.4 | 0.2 | 0.3 | -0.5 | 0.2 |
Fecal boli incidents, locomotor time 1 | 1.0 | 1.1 | 5.7 | -1.3 | 1.2 | -0.3 | -1.1 | 0.5 | -0.5 | -1.2 | 0.9 | -0.9 | 0.8 | -0.7 | -0.8 | 0.6 | -2.4 | -0.2 | -0.8 | -1.1 | -0.6 | 1.5 | 1.0 |
Food seeking constrained by brief footshock | 1.0 | 1.2 | 2.5 | 0.1 | 0.4 | -0.3 | -0.7 | -1.5 | 1.5 | -0.6 | 1.0 | -1.0 | -1.5 | 1.5 | -1.1 | 1.4 | 1.3 | 1.6 | 1.4 | -0.1 | 1.6 | -0.1 | 0.4 |
Cu content in liver | 1.0 | 1.2 | 2.9 | 0.2 | 0.3 | 0.3 | -0.9 | -1.7 | 1.7 | -0.6 | 0.9 | -1.0 | -1.7 | 1.7 | -1.1 | 1.3 | 1.2 | 1.6 | 1.7 | 0.0 | 0.3 | -0.2 | 0.3 |
Epididymis fat weight | 0.9 | 2.0 | 4.8 | 2.1 | -1.9 | 1.7 | 0.6 | -0.8 | 0.8 | 1.7 | -1.5 | 1.2 | -0.2 | 0.6 | 1.0 | -0.3 | 1.7 | 0.5 | 0.8 | 2.2 | -1.6 | -2.2 | -2.0 |
Heart weight | 0.9 | 1.2 | 2.1 | -1.3 | 1.4 | -1.2 | -1.4 | -0.4 | 0.4 | -1.4 | 1.3 | -1.4 | -0.7 | 0.5 | -1.4 | 1.4 | -0.5 | 0.8 | 0.0 | -1.3 | 1.0 | 1.2 | 1.3 |
Parametrial fat weight | 0.9 | 1.7 | 5.6 | 2.0 | -1.7 | 0.6 | 0.7 | 0.2 | -0.2 | 1.9 | -2.4 | 1.7 | 0.6 | -0.3 | 1.5 | -1.0 | 1.3 | -0.0 | -0.3 | 1.9 | -0.6 | -2.0 | -1.2 |
Soleus weight | 0.9 | 2.7 | 5.7 | 2.0 | -1.6 | 2.3 | 0.3 | -2.1 | 2.1 | 1.1 | -0.5 | 0.2 | -1.5 | 1.9 | 0.1 | 0.4 | 2.2 | 1.5 | 1.6 | 2.1 | -2.4 | -2.1 | -1.5 |
Delay discounting water rate 6 sec | 0.9 | 1.4 | 2.9 | -1.6 | 1.6 | -1.0 | -1.4 | -0.0 | 0.0 | -1.6 | 1.4 | -1.4 | -0.4 | 0.1 | -1.4 | 1.1 | -1.1 | 0.6 | -0.2 | -1.5 | 0.7 | 1.6 | 1.7 |
Reaction time mean minus median AUC | 0.9 | 1.1 | 3.3 | -1.1 | 1.1 | -0.3 | -1.0 | -0.9 | 0.9 | -1.3 | 1.8 | -1.5 | -1.0 | 0.9 | -1.4 | 1.1 | -0.5 | 0.9 | 0.9 | -1.0 | 0.8 | 1.0 | 0.7 |
Reaction time mean | 0.9 | 1.2 | 3.8 | 1.3 | -1.5 | 1.9 | 1.2 | -0.8 | 0.8 | 1.2 | -0.3 | 0.8 | -0.2 | 0.6 | 0.8 | -0.8 | 0.7 | -0.2 | 0.7 | 1.4 | -1.4 | -1.3 | -1.8 |
Reaction time mean AUC | 0.9 | 1.1 | 3.2 | 1.3 | -1.5 | 1.6 | 1.4 | -0.4 | 0.4 | 1.3 | -0.5 | 1.0 | 0.1 | 0.2 | 1.0 | -1.2 | 0.6 | -0.5 | 0.4 | 1.4 | -1.1 | -1.3 | -1.8 |
Post-drug Anxiety | 0.9 | 1.0 | 1.9 | 1.3 | -1.3 | 1.4 | 1.3 | -0.5 | 0.5 | 1.2 | -0.7 | 0.9 | -0.1 | 0.3 | 0.9 | -1.2 | 1.0 | -0.2 | 0.7 | 1.3 | -0.7 | -1.3 | -1.2 |
Baseline Anxiety | 0.9 | 1.0 | 2.3 | -0.5 | 0.9 | -0.8 | -1.4 | -0.5 | 0.5 | -1.1 | 1.0 | -1.3 | -1.0 | 0.8 | -1.4 | 1.4 | 0.7 | 1.5 | 0.5 | -0.7 | 0.2 | 0.5 | 1.3 |
Pavlov. Cond. lever latency | 0.9 | 1.2 | 2.2 | 0.8 | -1.2 | 0.9 | 1.3 | 0.8 | -0.8 | 1.3 | -1.3 | 1.4 | 1.1 | -0.9 | 1.4 | -1.5 | -0.0 | -1.2 | -0.8 | 1.0 | -1.0 | -0.8 | -1.3 |
Pavlov. Cond. lever contacts | 0.9 | 1.0 | 2.3 | -0.5 | 1.0 | -0.8 | -1.4 | -0.8 | 0.8 | -1.1 | 1.0 | -1.2 | -1.1 | 0.9 | -1.3 | 1.5 | 0.3 | 1.4 | 0.9 | -0.7 | 0.8 | 0.5 | 1.2 |
Pavlov. Cond. response bias | 0.9 | 1.1 | 2.2 | -0.6 | 1.0 | -0.9 | -1.4 | -0.8 | 0.8 | -1.1 | 1.1 | -1.3 | -1.1 | 0.9 | -1.4 | 1.5 | 0.3 | 1.4 | 0.7 | -0.7 | 1.0 | 0.6 | 1.2 |
Bone: periosteal estimation | 0.9 | 1.9 | 4.6 | -0.2 | 0.7 | 0.0 | -1.5 | -1.8 | 1.8 | -1.1 | 1.4 | -1.6 | -2.0 | 1.9 | -1.7 | 1.9 | 1.2 | 2.1 | 1.5 | -0.3 | 0.1 | 0.1 | 0.8 |
Bone: trabecular number | 0.9 | 1.4 | 3.4 | 0.2 | -0.5 | -0.6 | 1.0 | 1.8 | -1.8 | 0.9 | -1.3 | 1.4 | 1.7 | -1.8 | 1.4 | -1.4 | -0.7 | -1.6 | -1.8 | 0.2 | 0.5 | -0.2 | -0.2 |
Time to tail flick, test, before self-admin | 0.9 | 0.9 | 6.6 | 0.1 | 0.4 | -1.1 | -0.4 | -0.9 | 0.9 | -0.4 | 0.7 | -0.6 | -1.2 | 1.0 | -0.7 | 0.9 | 1.1 | 1.1 | 1.1 | -0.2 | 2.6 | -0.1 | 0.5 |
Seeking ratio, delayed vs. immediate footshock | 0.9 | 1.0 | 2.3 | 0.2 | -0.6 | -0.1 | 1.1 | 1.1 | -1.1 | 0.9 | -1.0 | 1.4 | 1.3 | -1.2 | 1.4 | -1.5 | -0.8 | -1.5 | -1.3 | 0.3 | -0.0 | -0.2 | -1.0 |
Left kidney weight | 0.8 | 2.2 | 5.8 | 0.6 | 0.1 | 0.7 | -1.4 | -2.2 | 2.2 | -0.5 | 0.9 | -1.2 | -2.1 | 2.2 | -1.4 | 2.0 | 1.8 | 2.4 | 2.1 | 0.5 | -0.9 | -0.7 | 0.1 |
Reaction time premature initiations | 0.8 | 1.2 | 2.6 | -0.4 | 0.7 | -0.1 | -1.2 | -1.3 | 1.3 | -1.0 | 1.2 | -1.4 | -1.4 | 1.3 | -1.4 | 1.5 | 0.5 | 1.6 | 1.4 | -0.4 | 0.5 | 0.3 | 0.8 |
Std. dev. reaction times | 0.8 | 1.1 | 3.1 | 0.8 | -0.5 | 1.2 | -0.2 | -1.8 | 1.8 | 0.1 | 0.7 | -0.5 | -1.5 | 1.7 | -0.6 | 0.8 | 1.2 | 1.3 | 1.5 | 0.8 | -0.4 | -0.9 | -0.7 |
Social response proportion | 0.8 | 0.8 | 3.3 | 0.9 | -1.0 | 1.8 | 0.5 | -1.0 | 1.0 | 0.7 | -0.2 | 0.3 | -0.5 | 0.8 | 0.3 | -0.4 | 0.7 | 0.3 | 0.9 | 1.1 | -1.7 | -1.0 | -1.2 |
Pavlov. Cond. intertrial magazine entries | 0.8 | 1.0 | 3.0 | 1.1 | -0.7 | 0.7 | 0.0 | -1.4 | 1.4 | 0.5 | -0.0 | -0.1 | -1.3 | 1.4 | -0.2 | 0.5 | 1.7 | 1.2 | 1.6 | 1.0 | -0.3 | -1.1 | -0.5 |
Progressive ratio test 2 inactive lever presses | 0.8 | 0.9 | 2.3 | -1.2 | 1.3 | -0.9 | -1.1 | 0.3 | -0.3 | -1.4 | 1.0 | -1.3 | -0.1 | -0.2 | -1.2 | 1.0 | -0.6 | 0.4 | -0.2 | -1.3 | 0.6 | 1.2 | 1.5 |
Compulsive drug intake | 0.8 | 0.8 | 2.1 | -0.7 | 0.2 | -0.4 | 0.0 | 1.4 | -1.4 | -0.0 | -0.7 | 0.4 | 1.4 | -1.4 | 0.5 | -0.5 | -1.4 | -1.0 | -1.4 | -0.4 | -0.9 | 0.6 | 0.4 |
Locomotion velocity, session 1 | 0.8 | 0.8 | 2.5 | -0.4 | 0.2 | -0.7 | 0.1 | 1.4 | -1.4 | 0.1 | -0.7 | 0.6 | 1.4 | -1.4 | 0.6 | -0.7 | -1.2 | -1.1 | -1.6 | -0.4 | 0.1 | 0.5 | 0.4 |
Locomotion distance, session 1 | 0.8 | 1.0 | 2.9 | -1.3 | 1.4 | -1.6 | -1.0 | 0.4 | -0.4 | -1.2 | 0.8 | -0.9 | 0.0 | -0.3 | -0.9 | 0.8 | -0.9 | 0.2 | -0.6 | -1.4 | 1.2 | 1.3 | 1.7 |
Locomotion velocity, session 8 | 0.8 | 0.9 | 3.1 | -1.0 | 1.1 | -1.1 | -0.8 | -0.5 | 0.5 | -1.1 | 1.1 | -1.1 | -0.8 | 0.6 | -1.1 | 0.9 | -0.1 | 0.6 | 0.6 | -1.1 | 1.8 | 1.0 | 1.2 |
Bone: connectivity density | 0.8 | 1.2 | 3.2 | -0.8 | 0.7 | -1.6 | -0.5 | 1.7 | -1.7 | -0.3 | -0.6 | 0.3 | 1.5 | -1.7 | 0.3 | -0.1 | -1.2 | -0.8 | -1.8 | -0.8 | 0.9 | 0.8 | 1.0 |
Bone: cortical porosity | 0.8 | 0.9 | 2.1 | -1.5 | 1.3 | -1.1 | -0.8 | 0.4 | -0.4 | -1.2 | 1.1 | -0.9 | 0.1 | -0.3 | -0.9 | 0.6 | -1.2 | -0.1 | -0.2 | -1.4 | 0.7 | 1.4 | 1.1 |
Bone: marrow area | 0.8 | 1.8 | 4.8 | 0.1 | 0.5 | 0.2 | -1.5 | -1.7 | 1.7 | -0.9 | 1.2 | -1.5 | -1.9 | 1.9 | -1.6 | 1.9 | 1.3 | 2.2 | 1.5 | -0.0 | -0.2 | -0.1 | 0.6 |
Bone: stiffness | 0.8 | 1.3 | 4.3 | 1.0 | -1.0 | 2.1 | 0.8 | -1.4 | 1.4 | 0.6 | 0.4 | 0.0 | -1.1 | 1.3 | 0.1 | -0.3 | 1.2 | 0.4 | 1.5 | 1.1 | -1.6 | -1.0 | -1.3 |
Change in fecal boli incidents, locomotor task | 0.8 | 0.8 | 2.0 | 1.0 | -1.1 | 0.8 | 0.9 | 0.3 | -0.3 | 1.1 | -1.4 | 1.0 | 0.5 | -0.3 | 1.0 | -1.0 | 0.9 | -0.4 | -0.3 | 1.0 | -1.1 | -1.0 | -0.8 |
Locomotion in novel chamber | 0.8 | 1.0 | 4.7 | -1.2 | 1.1 | -0.9 | -0.7 | 0.8 | -0.8 | -0.9 | 0.6 | -0.5 | 0.8 | -0.9 | -0.4 | 0.6 | -2.2 | -0.7 | -0.8 | -1.2 | 0.5 | 1.5 | 0.8 |
Latency to leave start box in cocaine runway, M | 0.8 | 0.7 | 2.0 | -0.0 | -0.2 | -0.2 | 0.3 | 1.4 | -1.4 | 0.4 | -1.1 | 0.8 | 1.3 | -1.4 | 0.8 | -0.9 | -0.8 | -1.0 | -1.3 | 0.1 | -0.6 | 0.0 | -0.1 |
BMI without tail | 0.7 | 1.4 | 4.2 | 1.4 | -0.6 | 0.5 | -1.0 | -1.5 | 1.5 | 0.4 | -0.5 | -0.3 | -1.3 | 1.5 | -0.5 | 1.3 | 2.1 | 2.0 | 1.3 | 1.2 | -0.8 | -1.4 | -0.4 |
Body weight | 0.7 | 3.1 | 8.4 | 1.9 | -1.0 | 1.7 | -0.4 | -2.5 | 2.5 | 0.5 | 0.1 | -0.5 | -2.3 | 2.5 | -0.7 | 1.2 | 2.9 | 2.3 | 2.4 | 1.6 | -0.9 | -1.8 | -1.1 |
Intermittent access total locomotion | 0.7 | 0.8 | 1.9 | -0.8 | 1.1 | -0.9 | -0.9 | -0.0 | 0.0 | -1.1 | 1.0 | -1.1 | -0.3 | 0.1 | -1.1 | 1.0 | -0.1 | 0.6 | 0.3 | -1.1 | 1.3 | 0.9 | 1.4 |
Locomotion velocity, session 3 | 0.7 | 0.9 | 2.1 | -1.2 | 1.2 | -1.1 | -0.6 | 0.3 | -0.3 | -1.1 | 1.1 | -0.9 | -0.1 | -0.2 | -0.8 | 0.6 | -0.9 | -0.1 | -0.3 | -1.4 | 1.4 | 1.3 | 1.3 |
Condit. Reinf. active-inactive response ratio | 0.7 | 0.8 | 1.9 | 0.2 | 0.2 | 0.2 | -0.7 | -1.4 | 1.4 | -0.4 | 0.8 | -0.8 | -1.4 | 1.4 | -0.9 | 1.0 | 0.9 | 1.3 | 1.3 | 0.1 | 0.2 | -0.2 | 0.2 |
Time in novel zone, NPP test | 0.7 | 0.7 | 2.7 | -0.5 | 0.4 | 0.9 | 0.2 | -1.2 | 1.2 | -0.7 | 1.7 | -1.0 | -1.3 | 1.2 | -0.9 | 0.4 | 0.1 | 0.4 | 1.3 | -0.5 | -0.0 | 0.5 | -0.2 |
Time in closed arm after self-admin | 0.7 | 0.7 | 1.7 | -0.0 | -0.4 | 0.5 | 1.1 | 1.1 | -1.1 | 0.5 | -0.8 | 0.7 | 1.1 | -1.1 | 0.8 | -1.2 | -0.9 | -1.3 | -1.0 | 0.1 | -1.0 | 0.1 | -0.1 |
Right kidney weight | 0.6 | 1.6 | 3.6 | 0.6 | -0.1 | 0.9 | -0.9 | -1.9 | 1.9 | -0.3 | 0.9 | -0.9 | -1.8 | 1.9 | -1.0 | 1.5 | 1.5 | 1.9 | 1.9 | 0.6 | -0.8 | -0.7 | -0.2 |
Reaction time mean minus median | 0.6 | 0.8 | 1.8 | -0.3 | 0.6 | 0.1 | -0.8 | -1.2 | 1.2 | -0.8 | 1.3 | -1.2 | -1.2 | 1.2 | -1.2 | 1.1 | 0.3 | 1.2 | 1.1 | -0.3 | 0.7 | 0.3 | 0.4 |
Cocaine response after cond. not corrected | 0.6 | 0.7 | 2.1 | 0.9 | -0.9 | 0.3 | 0.4 | 0.7 | -0.7 | 1.0 | -1.4 | 1.0 | 0.9 | -0.8 | 1.0 | -0.7 | 0.2 | -0.4 | -1.1 | 0.9 | -0.9 | -0.8 | -0.7 |
Progressive ratio test 2 active lever presses | 0.6 | 0.6 | 1.7 | -0.4 | 0.8 | -0.5 | -1.1 | -0.2 | 0.2 | -0.9 | 0.8 | -1.1 | -0.7 | 0.4 | -1.1 | 1.3 | 0.5 | 1.1 | 0.3 | -0.6 | 0.7 | 0.5 | 1.2 |
Progressive ratio test 2 breakpoint | 0.6 | 0.7 | 1.8 | -0.4 | 0.8 | -0.4 | -1.1 | -0.3 | 0.3 | -0.9 | 0.9 | -1.1 | -0.8 | 0.5 | -1.2 | 1.3 | 0.6 | 1.2 | 0.5 | -0.6 | 0.6 | 0.4 | 1.1 |
Stereotopy head waving bouts, day 3 | 0.6 | 0.7 | 1.5 | 1.0 | -0.9 | 1.0 | 0.9 | -1.0 | 1.0 | 0.7 | -0.2 | 0.4 | -0.8 | 1.0 | 0.3 | -0.4 | 1.2 | 0.3 | 1.0 | 0.9 | -0.5 | -1.0 | -0.7 |
Pavlov. Cond. intertrial magazine entries | 0.6 | 0.8 | 1.7 | 0.7 | -0.9 | 0.6 | 1.2 | 0.7 | -0.7 | 1.0 | -1.1 | 1.2 | 0.8 | -0.7 | 1.2 | -1.3 | 0.1 | -1.0 | -0.9 | 0.7 | -0.3 | -0.6 | -0.9 |
Bone: cortical area | 0.6 | 0.9 | 2.4 | -0.0 | 0.3 | 0.4 | -0.4 | -1.4 | 1.4 | -0.6 | 1.1 | -1.0 | -1.5 | 1.5 | -1.0 | 0.9 | 0.9 | 1.2 | 1.2 | -0.1 | 0.1 | 0.0 | 0.3 |
Bone: trabecular spacing | 0.6 | 0.7 | 1.5 | -1.0 | 1.1 | -1.1 | -1.2 | -0.0 | 0.0 | -1.1 | 0.7 | -1.0 | -0.3 | 0.2 | -1.1 | 1.0 | -0.5 | 0.7 | 0.1 | -1.0 | 0.9 | 0.9 | 1.0 |
Ambulatory time after self-admin | 0.6 | 0.7 | 1.7 | -1.2 | 0.7 | -0.8 | 0.6 | 0.8 | -0.8 | -0.5 | 0.7 | -0.1 | 0.5 | -0.7 | 0.1 | -0.7 | -1.1 | -1.2 | -0.6 | -1.1 | 1.3 | 1.2 | 0.3 |
Delay disc. indifference point, 2s delay | 0.6 | 0.6 | 1.6 | 0.1 | 0.3 | -0.1 | -0.7 | -1.1 | 1.1 | -0.4 | 0.5 | -0.7 | -1.0 | 1.1 | -0.8 | 1.2 | 1.1 | 1.3 | 1.0 | -0.0 | -0.0 | -0.3 | 0.6 |
Cd content in liver | 0.6 | 0.7 | 1.7 | 1.3 | -1.1 | 0.6 | 0.5 | -0.0 | 0.0 | 1.1 | -1.3 | 1.0 | 0.3 | -0.0 | 0.9 | -0.5 | 0.9 | 0.0 | -0.1 | 1.2 | -0.4 | -1.3 | -0.8 |
Times rat made contact with spout | 0.5 | 0.6 | 2.0 | 1.2 | -1.0 | 0.5 | 0.4 | -0.4 | 0.4 | 0.9 | -0.7 | 0.7 | -0.3 | 0.4 | 0.5 | -0.2 | 1.4 | 0.4 | 0.5 | 1.1 | -0.2 | -1.2 | -0.8 |
Water consumed over 24 hours | 0.5 | 0.6 | 1.0 | 0.4 | -0.6 | -0.0 | 0.8 | 1.0 | -1.0 | 0.8 | -0.8 | 1.0 | 0.9 | -1.0 | 1.0 | -0.9 | -0.0 | -0.9 | -0.9 | 0.4 | 0.3 | -0.4 | -0.5 |
Indifference point AUC | 0.5 | 0.6 | 2.1 | 0.9 | -0.5 | 0.7 | 0.0 | -1.1 | 1.1 | 0.3 | -0.3 | -0.1 | -1.0 | 1.1 | -0.2 | 0.6 | 1.4 | 1.0 | 0.5 | 0.7 | 0.5 | -0.9 | 0.2 |
Reaction time number correct | 0.5 | 0.7 | 2.0 | -1.1 | 0.8 | -0.6 | 0.2 | 0.9 | -0.9 | -0.7 | 0.6 | -0.3 | 0.7 | -0.9 | -0.1 | -0.5 | -1.4 | -0.9 | -0.8 | -1.1 | 0.7 | 1.2 | 0.6 |
Reaction time trials correct on left | 0.5 | 0.7 | 2.0 | -1.1 | 0.8 | -0.6 | 0.2 | 0.9 | -0.9 | -0.7 | 0.6 | -0.3 | 0.7 | -0.9 | -0.1 | -0.5 | -1.4 | -0.9 | -0.8 | -1.1 | 0.7 | 1.2 | 0.6 |
Reaction time trials on left | 0.5 | 0.7 | 2.1 | -1.1 | 0.8 | -0.6 | 0.2 | 0.9 | -0.9 | -0.7 | 0.6 | -0.2 | 0.7 | -0.9 | -0.1 | -0.5 | -1.4 | -1.0 | -0.8 | -1.1 | 0.7 | 1.2 | 0.6 |
Reaction time trials completed | 0.5 | 0.7 | 2.1 | -1.1 | 0.8 | -0.6 | 0.2 | 0.9 | -0.9 | -0.7 | 0.6 | -0.2 | 0.7 | -0.9 | -0.1 | -0.5 | -1.4 | -1.0 | -0.8 | -1.1 | 0.7 | 1.2 | 0.6 |
Intermittent access intake escalation | 0.5 | 0.5 | 1.8 | -0.9 | 1.0 | -1.1 | -1.0 | 0.2 | -0.2 | -0.9 | 0.5 | -0.7 | -0.0 | -0.1 | -0.8 | 0.8 | -0.2 | 0.5 | -0.1 | -0.9 | 0.2 | 0.8 | 1.4 |
Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 1.6 | 0.3 | -0.1 | 0.4 | -0.2 | -1.3 | 1.3 | -0.2 | 0.6 | -0.6 | -1.2 | 1.2 | -0.6 | 0.6 | 0.9 | 1.0 | 1.1 | 0.2 | 0.1 | -0.3 | 0.1 |
Total zone transitions, hab. session 1 | 0.5 | 0.7 | 4.9 | -0.8 | 0.6 | -1.6 | 0.1 | 0.9 | -0.9 | -0.3 | -0.0 | 0.1 | 0.5 | -0.7 | 0.1 | -0.2 | -0.5 | -0.6 | -0.8 | -0.8 | 2.2 | 0.7 | 1.0 |
Time in novel zone, hab. session 2 | 0.5 | 0.5 | 1.2 | 0.1 | -0.3 | -0.4 | 0.6 | 1.0 | -1.0 | 0.5 | -1.0 | 0.8 | 1.0 | -1.0 | 0.8 | -0.8 | -0.4 | -0.9 | -1.1 | 0.1 | 0.5 | -0.1 | -0.1 |
Novel to familiar place preference ratio | 0.5 | 0.5 | 1.9 | -0.3 | 0.2 | 1.0 | 0.3 | -1.1 | 1.1 | -0.5 | 1.4 | -0.8 | -1.1 | 1.0 | -0.6 | 0.2 | 0.2 | 0.3 | 1.2 | -0.3 | -0.1 | 0.3 | -0.4 |
Novelty place preference | 0.5 | 0.6 | 2.0 | -0.3 | 0.2 | 1.0 | 0.3 | -1.1 | 1.1 | -0.5 | 1.4 | -0.8 | -1.2 | 1.1 | -0.6 | 0.2 | 0.3 | 0.3 | 1.2 | -0.3 | 0.0 | 0.3 | -0.4 |
Total zone transitions, NPP test | 0.5 | 0.7 | 3.7 | -0.9 | 0.9 | -1.6 | -0.4 | 0.6 | -0.6 | -0.7 | 0.4 | -0.3 | 0.3 | -0.5 | -0.3 | 0.3 | -0.7 | -0.2 | -0.4 | -1.0 | 1.9 | 0.9 | 1.2 |
Bone surface | 0.5 | 0.9 | 1.7 | -0.9 | 1.1 | -0.9 | -1.3 | -0.3 | 0.3 | -1.2 | 1.0 | -1.2 | -0.7 | 0.5 | -1.2 | 1.3 | -0.0 | 1.0 | 0.1 | -1.0 | 0.9 | 0.9 | 1.3 |
Time in open arm after self-admin | 0.5 | 0.6 | 1.2 | 0.7 | -0.4 | 0.6 | -0.7 | -1.1 | 1.1 | 0.2 | -0.0 | -0.2 | -0.7 | 1.0 | -0.3 | 1.0 | 0.9 | 1.1 | 0.9 | 0.7 | -1.1 | -0.7 | -0.6 |
Delay disc. indifference point, 0s delay | 0.5 | 0.6 | 1.3 | -0.4 | 0.6 | -0.1 | -0.8 | -0.8 | 0.8 | -0.8 | 0.9 | -1.0 | -1.0 | 0.9 | -1.0 | 1.1 | 0.4 | 1.0 | 0.5 | -0.5 | 0.3 | 0.4 | 0.8 |
Weight adjusted by age | 0.5 | 0.6 | 1.7 | 0.3 | 0.0 | 0.3 | -0.7 | -1.2 | 1.2 | -0.2 | 0.6 | -0.6 | -1.0 | 1.2 | -0.7 | 1.0 | 0.8 | 1.2 | 1.3 | 0.3 | -0.2 | -0.4 | 0.0 |
Rb content in liver | 0.5 | 0.7 | 1.3 | -0.5 | 0.9 | -0.9 | -1.2 | -0.5 | 0.5 | -0.9 | 0.7 | -1.0 | -0.8 | 0.6 | -1.1 | 1.1 | 0.4 | 1.1 | 0.5 | -0.7 | 0.9 | 0.5 | 1.1 |
Sr content in liver | 0.5 | 0.5 | 1.4 | -0.6 | 0.4 | -1.0 | -0.2 | 1.0 | -1.0 | -0.2 | -0.5 | 0.2 | 0.9 | -1.0 | 0.2 | -0.3 | -0.8 | -0.6 | -1.2 | -0.5 | 0.7 | 0.6 | 0.7 |
Locomotor activity | 0.4 | 0.6 | 1.7 | -1.0 | 0.8 | -0.1 | -0.4 | -0.5 | 0.5 | -1.0 | 1.3 | -1.1 | -0.8 | 0.6 | -1.0 | 0.9 | -0.3 | 0.5 | 0.4 | -0.8 | -0.4 | 0.9 | 0.8 |
Intermittent access intake day 1-15 change | 0.4 | 0.4 | 1.4 | -0.8 | 0.9 | -1.0 | -0.9 | 0.1 | -0.1 | -0.8 | 0.4 | -0.7 | -0.0 | -0.1 | -0.7 | 0.8 | -0.1 | 0.5 | -0.1 | -0.8 | 0.1 | 0.7 | 1.2 |
Intermitt. access day 1 inactive lever presses | 0.4 | 0.5 | 1.9 | 0.6 | -0.8 | 1.4 | 0.4 | -0.4 | 0.4 | 0.6 | -0.4 | 0.3 | 0.1 | 0.2 | 0.4 | -0.3 | 0.3 | 0.0 | 0.6 | 0.8 | -1.4 | -0.8 | -1.1 |
Incentive salience index mean | 0.4 | 0.5 | 1.3 | 0.2 | 0.1 | 0.2 | -0.3 | -1.1 | 1.1 | -0.3 | 0.7 | -0.6 | -1.1 | 1.1 | -0.7 | 0.7 | 0.7 | 0.9 | 1.0 | 0.1 | 0.3 | -0.2 | 0.2 |
Bone: trabecular thickness | 0.4 | 0.5 | 1.8 | 0.6 | -0.7 | 1.4 | 0.9 | -0.8 | 0.8 | 0.5 | 0.3 | 0.2 | -0.7 | 0.8 | 0.3 | -0.5 | 0.8 | -0.0 | 0.9 | 0.6 | -0.5 | -0.5 | -0.9 |
Delta time to tail flick, test, before/after SA | 0.4 | 0.4 | 3.1 | 0.6 | -0.6 | 1.1 | 0.4 | -0.1 | 0.1 | 0.5 | -0.7 | 0.4 | 0.1 | 0.0 | 0.4 | -0.6 | 0.4 | -0.1 | -0.2 | 0.6 | -1.7 | -0.6 | -0.6 |
Total heroin consumption | 0.4 | 0.5 | 1.4 | -0.9 | 0.8 | -0.6 | -0.1 | -0.4 | 0.4 | -0.9 | 1.2 | -0.8 | -0.9 | 0.5 | -0.8 | 0.2 | -0.2 | 0.1 | 0.4 | -1.0 | 0.5 | 0.9 | 0.9 |
Distance moved, locomotor task time 1 | 0.4 | 0.4 | 1.5 | 0.7 | -0.5 | 0.3 | -0.3 | -0.8 | 0.8 | 0.3 | 0.0 | -0.0 | -0.7 | 0.8 | -0.1 | 0.7 | 1.2 | 0.9 | 1.0 | 0.7 | -0.1 | -0.8 | -0.5 |
Vertical activity count, locomotor time 1 | 0.4 | 0.4 | 1.1 | 0.2 | -0.0 | 0.2 | -0.4 | -0.9 | 0.9 | -0.2 | 0.5 | -0.5 | -0.9 | 0.9 | -0.6 | 0.7 | 0.8 | 1.0 | 1.1 | 0.2 | 0.6 | -0.2 | -0.2 |
K content in liver | 0.4 | 0.4 | 1.3 | 0.7 | -0.7 | 1.2 | 0.5 | -0.7 | 0.7 | 0.6 | -0.1 | 0.3 | -0.4 | 0.6 | 0.3 | -0.3 | 0.8 | 0.2 | 0.6 | 0.8 | -0.9 | -0.8 | -0.8 |
Na content in liver | 0.4 | 0.5 | 1.9 | -0.8 | 0.8 | -1.4 | -0.7 | 0.5 | -0.5 | -0.6 | 0.2 | -0.4 | 0.0 | -0.3 | -0.5 | 0.5 | -0.1 | 0.2 | -0.7 | -0.7 | 1.3 | 0.7 | 1.1 |
Delay discounting total patch changes 6 sec | 0.3 | 0.5 | 1.0 | -0.8 | 0.8 | -0.1 | -0.8 | -0.3 | 0.3 | -1.0 | 0.9 | -1.0 | -0.5 | 0.4 | -1.0 | 1.0 | -0.4 | 0.6 | -0.2 | -0.7 | 0.4 | 0.8 | 0.8 |
Reaction time omissions | 0.3 | 0.4 | 1.0 | 0.8 | -0.9 | 0.8 | 0.8 | -0.2 | 0.2 | 0.8 | -0.4 | 0.6 | 0.0 | 0.1 | 0.6 | -0.5 | 0.6 | -0.2 | 0.1 | 0.9 | -0.6 | -0.9 | -1.0 |
Reaction time trials AUC | 0.3 | 0.4 | 1.5 | -1.0 | 0.6 | -0.3 | 0.2 | 0.7 | -0.7 | -0.6 | 0.6 | -0.3 | 0.5 | -0.6 | -0.1 | -0.4 | -1.2 | -0.8 | -0.6 | -0.9 | 0.4 | 1.0 | 0.5 |
Conditioned locomotion | 0.3 | 0.3 | 1.9 | -0.2 | -0.1 | 1.4 | 0.6 | -0.4 | 0.4 | -0.1 | 0.8 | -0.3 | -0.3 | 0.3 | -0.1 | -0.4 | -0.3 | -0.4 | 0.5 | -0.1 | -1.2 | 0.3 | -0.7 |
Intermitt. access day 15 inactive lever presses | 0.3 | 0.3 | 1.2 | -0.8 | 0.8 | -0.7 | -0.2 | 0.4 | -0.4 | -0.7 | 0.4 | -0.5 | 0.3 | -0.4 | -0.5 | 0.3 | -0.3 | -0.1 | -0.3 | -0.9 | 0.6 | 0.7 | 1.1 |
Intermitt. access escalation Index | 0.3 | 0.2 | 0.7 | -0.5 | 0.4 | 0.2 | -0.5 | -0.4 | 0.4 | -0.6 | 0.8 | -0.7 | -0.5 | 0.4 | -0.6 | 0.5 | -0.3 | 0.4 | 0.5 | -0.4 | -0.8 | 0.4 | 0.2 |
Intermittent access day 1 locomotion | 0.3 | 0.3 | 1.1 | -0.6 | 0.7 | -0.6 | -0.2 | 0.4 | -0.4 | -0.6 | 0.5 | -0.5 | 0.1 | -0.3 | -0.4 | 0.3 | -0.3 | -0.1 | -0.2 | -0.7 | 1.0 | 0.7 | 0.8 |
Progressive ratio test 1 inactive lever presses | 0.3 | 0.3 | 0.9 | -0.6 | 0.7 | -0.5 | -0.9 | -0.0 | 0.0 | -0.8 | 0.4 | -0.9 | -0.1 | 0.1 | -0.9 | 0.6 | -0.1 | 0.6 | 0.1 | -0.6 | 0.3 | 0.4 | 0.8 |
Number of responses in last shaping day | 0.3 | 0.3 | 0.9 | 0.2 | 0.1 | 0.4 | -0.5 | -0.5 | 0.5 | -0.3 | 0.2 | -0.5 | -0.7 | 0.6 | -0.5 | 0.7 | 0.5 | 0.8 | 0.6 | 0.1 | -1.0 | -0.1 | 0.3 |
Locomotion distance, session 2 | 0.3 | 0.5 | 1.0 | -0.9 | 0.9 | -0.7 | -0.6 | -0.2 | 0.2 | -0.9 | 1.0 | -0.8 | -0.4 | 0.3 | -0.8 | 0.7 | -0.5 | 0.3 | 0.3 | -0.9 | 0.5 | 0.8 | 0.9 |
Locomotion velocity, session 7 | 0.3 | 0.3 | 1.1 | 0.0 | -0.2 | -0.1 | 0.4 | 0.8 | -0.8 | 0.4 | -0.8 | 0.6 | 0.8 | -0.8 | 0.6 | -0.6 | -0.4 | -0.8 | -1.0 | 0.1 | 0.1 | 0.0 | -0.0 |
Condit. Reinf. active responses | 0.3 | 0.4 | 1.1 | 0.3 | -0.2 | 0.7 | 0.2 | -1.0 | 1.0 | 0.0 | 0.5 | -0.3 | -1.0 | 1.0 | -0.3 | 0.2 | 0.7 | 0.5 | 1.0 | 0.3 | -0.2 | -0.4 | -0.2 |
Bone: apparent density | 0.3 | 0.4 | 1.6 | -0.3 | 0.1 | -0.7 | 0.1 | 1.1 | -1.1 | 0.1 | -0.4 | 0.4 | 1.0 | -1.1 | 0.4 | -0.4 | -0.6 | -0.7 | -1.3 | -0.3 | 0.3 | 0.3 | 0.4 |
Bone volume | 0.3 | 0.5 | 1.1 | -0.7 | 0.9 | -0.5 | -0.9 | -0.4 | 0.4 | -1.0 | 1.0 | -1.0 | -0.7 | 0.5 | -1.0 | 0.9 | -0.1 | 0.7 | 0.1 | -0.8 | 0.4 | 0.7 | 1.0 |
Bone: final force | 0.3 | 0.4 | 2.2 | 0.2 | -0.3 | 1.3 | 0.4 | -0.8 | 0.8 | 0.0 | 0.7 | -0.3 | -0.6 | 0.7 | -0.2 | -0.2 | 0.3 | 0.1 | 0.9 | 0.3 | -1.5 | -0.2 | -0.6 |
Distance traveled after self-admin | 0.3 | 0.4 | 1.3 | -0.7 | 0.3 | -0.6 | 0.9 | 0.5 | -0.5 | -0.1 | 0.5 | 0.3 | 0.4 | -0.5 | 0.4 | -0.9 | -0.7 | -1.1 | -0.4 | -0.6 | 1.1 | 0.7 | -0.2 |
Bouts of movement, locomotor time 1 | 0.3 | 0.3 | 1.2 | -0.5 | 0.5 | -0.1 | -0.1 | -0.4 | 0.4 | -0.6 | 1.1 | -0.7 | -0.7 | 0.5 | -0.6 | 0.5 | -0.3 | 0.2 | 0.5 | -0.5 | 0.7 | 0.5 | 0.2 |
Total resting periods, locomotor time 1 | 0.3 | 0.3 | 0.9 | -0.8 | 0.6 | -0.3 | 0.1 | 0.2 | -0.2 | -0.6 | 0.9 | -0.4 | -0.0 | -0.1 | -0.3 | 0.1 | -0.9 | -0.4 | -0.2 | -0.8 | 1.0 | 0.8 | 0.3 |
Progressive ratio | 0.3 | 0.4 | 1.1 | -0.6 | 0.4 | -1.0 | -0.1 | 0.8 | -0.8 | -0.2 | -0.5 | 0.1 | 0.5 | -0.7 | 0.1 | 0.0 | -0.7 | -0.4 | -1.0 | -0.5 | 0.8 | 0.5 | 0.8 |
Glucose | 0.2 | 0.3 | 1.4 | -0.3 | 0.4 | -1.2 | -0.3 | 0.8 | -0.8 | -0.2 | -0.3 | 0.1 | 0.5 | -0.7 | 0.1 | 0.1 | -0.3 | -0.2 | -0.6 | -0.4 | 0.8 | 0.4 | 0.5 |
Extensor digitorum longus weight | 0.2 | 1.0 | 2.4 | 1.5 | -1.2 | 1.1 | 0.1 | -0.7 | 0.7 | 1.0 | -0.9 | 0.6 | -0.4 | 0.6 | 0.5 | 0.1 | 1.4 | 0.7 | 0.6 | 1.5 | -1.4 | -1.5 | -1.0 |
Tibialis anterior weight | 0.2 | 0.7 | 1.6 | 0.5 | -0.3 | 1.0 | -0.3 | -1.2 | 1.2 | -0.1 | 0.6 | -0.6 | -1.2 | 1.2 | -0.6 | 0.7 | 1.0 | 1.1 | 1.1 | 0.5 | -1.1 | -0.6 | -0.4 |
Conditioned reinforcement - inactives | 0.2 | 0.2 | 1.0 | 0.4 | -0.5 | 1.0 | 0.3 | -0.6 | 0.6 | 0.3 | -0.0 | 0.1 | -0.4 | 0.5 | 0.1 | -0.2 | 0.4 | 0.2 | 0.5 | 0.6 | -0.6 | -0.6 | -0.6 |
Intermittent access intake escalation 2 | 0.2 | 0.2 | 1.4 | 0.2 | -0.0 | 0.4 | -0.5 | -0.6 | 0.6 | -0.1 | 0.1 | -0.3 | -0.2 | 0.5 | -0.3 | 0.5 | 0.3 | 0.7 | 0.5 | 0.2 | -1.2 | -0.2 | 0.3 |
Short access day 10 total inactive lever presses | 0.2 | 0.2 | 1.3 | -0.1 | -0.3 | 0.5 | 0.3 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.8 | -0.5 | 0.4 | -0.4 | -0.5 | -0.5 | -0.2 | 0.2 | -1.1 | -0.1 | -0.3 |
Short access day 10 total locomotion | 0.2 | 0.2 | 0.7 | 0.0 | 0.3 | -0.0 | -0.4 | -0.4 | 0.4 | -0.4 | 0.7 | -0.5 | -0.4 | 0.4 | -0.5 | 0.8 | 0.5 | 0.6 | 0.8 | -0.1 | 0.6 | 0.1 | 0.3 |
Short access total locomotion | 0.2 | 0.2 | 0.9 | -0.2 | 0.5 | -0.8 | -0.5 | 0.4 | -0.4 | -0.4 | 0.3 | -0.3 | 0.1 | -0.3 | -0.4 | 0.4 | -0.1 | 0.2 | -0.2 | -0.5 | 0.9 | 0.4 | 0.6 |
Locomotion distance, session 7 | 0.2 | 0.2 | 0.9 | 0.4 | -0.5 | 0.9 | 0.4 | -0.2 | 0.2 | 0.4 | -0.2 | 0.3 | 0.1 | 0.1 | 0.4 | -0.4 | -0.0 | -0.2 | 0.2 | 0.5 | -0.9 | -0.4 | -0.7 |
Time in novel zone, hab. session 1 | 0.2 | 0.2 | 0.5 | 0.5 | -0.6 | 0.7 | 0.6 | -0.1 | 0.1 | 0.6 | -0.5 | 0.5 | 0.2 | -0.0 | 0.6 | -0.5 | -0.0 | -0.4 | -0.2 | 0.5 | -0.4 | -0.5 | -0.4 |
Bone: cortical thickness | 0.2 | 0.2 | 0.8 | -0.6 | 0.5 | 0.1 | -0.0 | -0.4 | 0.4 | -0.6 | 0.9 | -0.6 | -0.4 | 0.3 | -0.5 | 0.2 | -0.5 | 0.0 | 0.2 | -0.6 | -0.3 | 0.6 | 0.4 |
Bone: final moment | 0.2 | 0.4 | 1.7 | 0.0 | -0.1 | 1.1 | 0.1 | -0.8 | 0.8 | -0.2 | 0.9 | -0.5 | -0.8 | 0.8 | -0.4 | 0.1 | 0.3 | 0.4 | 0.9 | 0.1 | -1.3 | -0.0 | -0.4 |
Breakpoint value in progressive ratio session | 0.2 | 0.2 | 0.8 | -0.2 | -0.0 | -0.5 | 0.7 | 0.6 | -0.6 | 0.2 | -0.3 | 0.5 | 0.6 | -0.6 | 0.5 | -0.7 | -0.5 | -0.9 | -0.4 | -0.2 | 0.1 | 0.3 | -0.1 |
Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 1.9 | -0.1 | -0.1 | -0.4 | 0.9 | -0.2 | 0.2 | 0.2 | 0.4 | 0.3 | -0.3 | 0.2 | 0.3 | -0.4 | 0.3 | -0.6 | 0.3 | -0.2 | 1.4 | 0.1 | -0.4 |
Delay disc. indifference point, 16s delay | 0.2 | 0.2 | 2.2 | -0.0 | -0.2 | 0.9 | 0.4 | 0.3 | -0.3 | 0.1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.2 | -0.3 | -0.4 | -0.5 | -0.5 | 0.1 | -1.5 | -0.1 | -0.3 |
Delay discount exponential model param | 0.2 | 0.2 | 0.6 | -0.5 | 0.5 | -0.6 | -0.3 | -0.1 | 0.1 | -0.5 | 0.5 | -0.4 | -0.4 | 0.2 | -0.4 | 0.1 | -0.2 | 0.1 | 0.1 | -0.5 | 0.8 | 0.7 | 0.2 |
Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.5 | -0.5 | 0.3 | -0.3 | 0.2 | 0.5 | -0.5 | -0.3 | -0.0 | -0.1 | 0.2 | -0.4 | 0.0 | -0.4 | -0.7 | -0.6 | -0.6 | -0.5 | 0.3 | 0.6 | 0.4 |
Run reversals in cocaine runway, males | 0.2 | 0.2 | 0.8 | -0.0 | -0.0 | -0.6 | -0.0 | 0.7 | -0.7 | 0.2 | -0.7 | 0.4 | 0.6 | -0.6 | 0.4 | -0.3 | -0.3 | -0.4 | -0.9 | -0.0 | -0.3 | 0.0 | 0.5 |
BMI with tail | 0.1 | 0.3 | 1.4 | 0.6 | -0.4 | 0.4 | -0.2 | 0.3 | -0.3 | 0.4 | -1.1 | 0.4 | 0.6 | -0.4 | 0.3 | 0.0 | -0.1 | -0.0 | -0.6 | 0.6 | -1.2 | -0.6 | -0.3 |
Length without tail | 0.1 | 0.2 | 1.0 | 0.4 | -0.5 | 0.8 | 1.0 | -0.3 | 0.3 | 0.5 | 0.1 | 0.3 | -0.3 | 0.3 | 0.4 | -0.7 | 0.4 | -0.4 | 0.4 | 0.4 | 0.1 | -0.3 | -0.7 |
Intermittent access standard deviation | 0.1 | 0.1 | 0.3 | 0.1 | -0.0 | 0.2 | -0.2 | -0.5 | 0.5 | -0.0 | -0.0 | -0.1 | -0.2 | 0.4 | -0.1 | 0.6 | 0.3 | 0.3 | 0.4 | 0.1 | -0.5 | -0.2 | 0.2 |
Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 | -0.3 | 0.2 | 0.4 | -0.4 | 0.1 | -0.1 | 0.2 | 0.2 | -0.3 | 0.2 | -0.3 | 0.3 | -0.1 | -0.2 | -0.0 | 0.4 | -0.1 | 0.2 |
Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.4 | -0.2 | 0.1 | 0.1 | 0.1 | 0.4 | -0.4 | -0.1 | -0.0 | -0.1 | 0.3 | -0.4 | -0.1 | -0.5 | -0.1 | -0.1 | -0.1 | -0.2 | 0.7 | 0.0 | -0.0 |
Locomotion velocity, session 2 | 0.1 | 0.1 | 1.1 | -0.1 | 0.3 | -0.7 | -0.2 | -0.2 | 0.2 | -0.2 | 0.1 | -0.1 | -0.2 | 0.2 | -0.2 | 0.3 | 0.1 | 0.3 | 0.0 | -0.2 | 1.1 | 0.1 | 0.5 |
Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.4 | -0.5 | 0.4 | -0.4 | 0.0 | -0.0 | 0.0 | -0.4 | 0.4 | -0.3 | -0.2 | 0.1 | -0.3 | 0.1 | -0.2 | -0.0 | -0.0 | -0.5 | 0.4 | 0.5 | 0.7 |
Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.5 | 0.0 | -0.2 | 0.7 | 0.4 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | -0.3 | 0.3 | 0.1 | -0.6 | -0.0 | -0.4 |
Condit. Reinf. lever presses | 0.1 | 0.1 | 1.0 | -0.0 | 0.2 | -0.6 | -0.3 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.3 | 0.2 | -0.3 | 0.5 | 0.2 | 0.4 | 0.0 | -0.1 | 1.0 | 0.0 | 0.5 |
Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.5 | 0.4 | -0.2 | 0.0 | -0.1 | -0.3 | 0.3 | 0.2 | -0.0 | 0.0 | -0.4 | 0.4 | -0.0 | 0.1 | 0.7 | 0.4 | 0.5 | 0.3 | 0.1 | -0.4 | -0.3 |
Bone: cortical thickness | 0.1 | 0.1 | 0.4 | 0.2 | -0.4 | 0.4 | 0.7 | -0.0 | 0.0 | 0.3 | -0.2 | 0.3 | 0.0 | -0.0 | 0.4 | -0.6 | 0.1 | -0.4 | -0.2 | 0.3 | -0.1 | -0.2 | -0.3 |
Bone: maximum force | 0.1 | 0.2 | 0.5 | -0.0 | 0.0 | 0.7 | 0.0 | -0.6 | 0.6 | -0.2 | 0.7 | -0.4 | -0.6 | 0.6 | -0.4 | 0.1 | 0.3 | 0.3 | 0.6 | -0.0 | -0.7 | 0.0 | -0.2 |
Bone: maximum moment | 0.1 | 0.2 | 0.6 | -0.2 | 0.3 | 0.4 | -0.3 | -0.6 | 0.6 | -0.4 | 0.8 | -0.7 | -0.7 | 0.6 | -0.6 | 0.4 | 0.3 | 0.5 | 0.6 | -0.2 | -0.5 | 0.2 | 0.1 |
Bone: post-yield work | 0.1 | 0.2 | 0.5 | -0.4 | 0.4 | 0.2 | -0.4 | -0.4 | 0.4 | -0.5 | 0.7 | -0.6 | -0.4 | 0.4 | -0.6 | 0.5 | -0.2 | 0.3 | 0.4 | -0.4 | -0.2 | 0.4 | 0.4 |
Extinction: sum of active levers before priming | 0.1 | 0.1 | 0.2 | 0.3 | -0.3 | 0.0 | 0.2 | 0.2 | -0.2 | 0.4 | -0.4 | 0.4 | 0.2 | -0.2 | 0.3 | -0.1 | 0.2 | -0.1 | -0.3 | 0.3 | -0.1 | -0.3 | -0.4 |
Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.6 | -0.2 | 0.1 | -0.7 | 0.4 | 0.1 | -0.1 | -0.0 | 0.1 | 0.1 | -0.3 | 0.0 | 0.1 | -0.2 | 0.6 | -0.2 | -0.1 | -0.3 | 0.7 | 0.2 | -0.0 |
Area under the delay curve | 0.1 | 0.2 | 0.8 | 0.5 | -0.5 | 0.7 | 0.2 | -0.0 | 0.0 | 0.4 | -0.4 | 0.3 | 0.3 | -0.1 | 0.3 | -0.0 | 0.2 | -0.1 | -0.1 | 0.5 | -0.9 | -0.6 | -0.1 |
Delay discount hyperbolic model param | 0.1 | 0.1 | 0.5 | -0.5 | 0.4 | -0.6 | -0.1 | 0.2 | -0.2 | -0.4 | 0.3 | -0.2 | -0.1 | -0.1 | -0.2 | -0.2 | -0.4 | -0.2 | -0.2 | -0.5 | 0.7 | 0.7 | 0.0 |
Mg content in liver | 0.1 | 0.1 | 0.2 | -0.2 | 0.3 | 0.0 | -0.4 | -0.4 | 0.4 | -0.3 | 0.4 | -0.4 | -0.5 | 0.4 | -0.4 | 0.4 | 0.2 | 0.5 | 0.4 | -0.2 | 0.2 | 0.1 | 0.2 |
Progressive ratio test 1 breakpoint | 0.0 | 0.0 | 0.2 | 0.2 | -0.1 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.1 | 0.2 | 0.1 | -0.1 | 0.1 | -0.2 | 0.5 | 0.1 | -0.0 | 0.1 | 0.4 | -0.3 | 0.1 |
Delay disc. indifference point, 8s delay | 0.0 | 0.1 | 0.4 | 0.1 | -0.1 | 0.4 | -0.0 | 0.0 | -0.0 | 0.1 | -0.3 | 0.1 | 0.4 | -0.2 | 0.1 | 0.1 | -0.2 | -0.1 | -0.1 | 0.1 | -0.6 | -0.0 | 0.2 |
Fe content in liver | 0.0 | 0.1 | 0.2 | 0.3 | -0.3 | 0.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.1 | 0.1 | -0.2 | 0.2 | 0.1 | -0.1 | 0.5 | 0.1 | 0.2 | 0.3 | -0.1 | -0.3 | -0.3 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.