Hub : Genes

Btbd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000018788	0.05	0.04	7.0e-07	0.05	0.05	0.05	0.05	2.3e-06	2.9e-06	4.1e-06	3.0e-06
2	Brain	gene expression	ENSRNOG00000018788	0.03	0.03	8.1e-03	0.02	0.02	0.01	0.02	2.7e-03	4.4e-03	9.1e-02	4.4e-03
3	PL	gene expression	ENSRNOG00000018788	0.28	0.22	1.8e-03	0.01	0.03	0.03	0.03	4.7e-02	1.6e-03	2.8e-03	3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	5.7	18.5	23.1	-4.6	4.8	3.3
BMI without tail	3.1	6.5	9.1	-2.0	3.0	2.5
Body weight	1.1	4.5	6.1	-2.2	2.5	1.5
Epididymis fat weight	0.2	0.4	0.6	0.8	-0.7	0.5
Glucose	1.2	1.8	2.5	-1.4	1.6	1.0
Heart weight	0.2	0.3	0.7	0.8	-0.2	0.4
Left kidney weight	0.2	0.4	1.0	-0.0	-0.5	-1.0
Right kidney weight	1.2	3.4	3.9	1.9	-2.0	-1.6
Tail length	2.0	6.1	10.3	3.2	-2.5	-1.4
Length with tail	1.7	6.2	7.0	2.5	-2.6	-2.3
Length without tail	0.5	1.0	2.2	0.0	-0.9	-1.5
Liver weight, left	2.3	3.7	4.0	-1.9	2.0	1.9
Liver weight, right	1.2	2.0	3.2	-1.8	1.4	0.9
Parametrial fat weight	0.2	0.5	1.1	1.1	-0.4	-0.3
Retroperitoneal fat weight	0.3	1.1	1.3	-1.0	1.0	1.1
Intraocular pressure	0.8	1.2	2.7	0.5	0.7	1.7
Extensor digitorum longus weight	4.5	18.2	23.9	-4.1	4.9	3.8
Soleus weight	7.4	21.7	27.6	-5.2	5.3	3.3
Tibialis anterior weight	1.0	3.5	4.6	-2.1	2.1	1.3
Tibia length	0.7	1.9	2.9	1.7	-1.4	-0.8
Number of licking bursts	0.5	0.6	1.2	0.2	0.7	1.1
Food consumed during 24 hour testing period	0.6	0.7	1.1	-0.7	1.1	0.6
Times rat made contact with spout	0.6	0.6	1.1	-0.3	0.9	1.0
Mean time between licks in bursts	2.9	4.0	6.5	2.6	-2.2	-0.9
Mean num. licks in bursts	0.0	0.0	0.1	-0.3	0.0	-0.2
Std. dev. time between licks in bursts	0.9	1.1	1.7	0.8	-1.0	-1.3
Water consumed over 24 hours	0.4	0.5	1.0	-1.0	0.5	-0.4
Indifference point 0 sec	0.1	0.1	0.2	-0.5	0.3	-0.2
Indifference point AUC	0.6	0.7	1.3	1.1	-0.8	-0.5
Indifference point function ln k	0.3	0.4	0.7	-0.5	0.8	0.5
Indifference point function log k	0.3	0.4	0.7	-0.5	0.8	0.5
Delay discounting total patch changes 0 sec	0.1	0.1	0.1	-0.4	0.3	-0.0
Delay discounting total patch changes 12 sec	0.5	0.7	1.1	-0.4	0.9	1.1
Delay discounting total patch changes 18 sec	0.9	1.1	1.6	1.3	-1.2	-0.7
Delay discounting total patch changes 24 sec	0.1	0.1	0.1	0.3	-0.4	-0.3
Delay discounting total patch changes 6 sec	0.3	0.4	0.5	0.6	-0.7	-0.6
Delay discounting time to switch 0 sec	0.8	1.2	3.2	-1.8	0.2	-0.5
Delay discounting water rate 0 sec	0.7	1.2	1.9	0.6	1.1	1.4
Delay discounting water rate 12 sec	2.3	3.4	5.0	-0.8	2.2	2.2
Delay discounting water rate 18 sec	2.1	2.7	5.6	1.0	1.3	2.4
Delay discounting water rate 24 sec	2.8	3.8	7.5	0.1	2.0	2.7
Delay discounting water rate 6 sec	0.6	0.9	1.4	1.1	0.5	1.2
Locomotor activity	4.2	6.6	8.3	2.1	-2.7	-2.9
Locomotor testing distance	2.3	3.8	4.1	1.8	-2.0	-2.0
Locomotor testing rearing	0.1	0.1	0.2	0.3	0.3	0.5
Light reinforcement 1	5.4	9.8	13.9	3.1	-3.7	-2.4
Light reinforcement 2	2.0	2.7	4.0	1.5	-2.0	-1.3
Reaction time number correct	1.6	2.2	3.8	-0.5	1.6	1.9
Reaction time mean minus median	0.4	0.5	1.0	1.0	-0.5	-0.4
Reaction time mean minus median AUC	0.3	0.4	1.1	-0.2	-0.3	-1.0
Reaction time num false alarms	0.5	0.7	1.2	-0.1	1.1	1.0
Reaction time num false alarms AUC	0.8	1.1	1.7	-0.1	1.3	1.3
Reaction time trials correct on left	1.6	2.2	3.8	-0.5	1.6	1.9
Reaction time trials on left	1.5	2.1	3.4	-0.5	1.6	1.9
Reaction time mean	0.1	0.1	0.4	-0.2	-0.1	-0.6
Reaction time mean AUC	0.1	0.2	0.4	-0.3	-0.0	-0.6
Median of all reaction times	0.2	0.3	0.6	-0.8	0.3	-0.4
Reaction time omissions	0.4	0.5	0.6	0.5	-0.8	-0.8
Reaction time false alarm rate	0.0	0.1	0.1	-0.1	0.4	0.1
Reaction time premature initiation rate	0.6	0.9	2.0	1.4	-0.8	0.0
Reaction time premature initiations	0.6	0.9	1.6	1.3	0.0	1.0
Std. dev. reaction times	0.1	0.2	0.3	0.5	-0.3	-0.5
Reaction time trials completed	1.5	2.1	3.4	-0.5	1.6	1.9
Reaction time trials AUC	1.7	2.4	4.2	-0.4	1.7	2.1
Social response proportion	1.1	1.2	2.0	0.6	-1.4	-1.1
Social responses	6.7	8.6	10.5	2.8	-3.2	-2.7
Social time	0.3	0.4	0.8	-0.9	0.6	0.4
Conditioned locomotion	2.3	2.8	3.9	-1.0	1.9	2.0
Cocaine response after cond. corrected	7.1	7.9	11.3	-2.1	3.4	2.9
Cocaine response after cond. not corrected	7.6	8.5	11.8	-2.1	3.4	3.0
Cocaine response before conditioning	0.5	0.6	0.7	0.7	-0.8	-0.7
Saline control response	0.1	0.1	0.1	-0.1	0.3	0.4
Condit. Reinf. active minus inactive responses	1.3	1.6	3.7	1.9	-1.1	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	0.6	0.3	1.0
Condit. Reinf. active responses	1.3	1.9	3.4	1.8	-1.3	-0.8
Condit. Reinf. inactive responses	0.8	1.0	1.2	1.1	-1.0	-1.0
Condit. Reinf. lever presses	1.3	1.8	3.8	2.0	-1.2	-0.3
Condit. Reinf. lever reinforcers received	0.9	1.2	2.8	1.7	-0.9	-0.3
Pavlov. Cond. lever latency	0.5	0.7	1.1	-1.1	0.6	0.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	0.7	-0.5	-0.6
Pavlov. Cond. change in total contacts	0.4	0.6	1.2	1.1	-0.6	-0.5
Pavlov. Cond. index score	0.5	0.7	1.2	1.1	-0.6	-0.7
Pavlov. Cond. latency score	0.6	0.7	1.0	1.0	-0.7	-0.9
Pavlov. Cond. lever contacts	0.4	0.5	1.2	1.1	-0.4	-0.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.9	0.7	0.8
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.2	-0.4	0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.1	1.1	-0.7	-0.8
Pavlov. Cond. response bias	1.0	1.3	2.8	1.7	-0.9	-0.6
Conditioned reinforcement - actives	2.1	2.1	3.0	1.7	-1.4	-1.2
Conditioned reinforcement - inactives	0.8	0.9	1.3	-0.5	1.1	1.1
Conditioned locomotion	6.0	7.2	10.4	3.2	-2.8	-1.9
Intermittent access intake day 1-15 change	4.8	4.7	7.6	2.8	-2.2	-1.3
Intermittent access intake escalation	3.9	3.8	8.2	2.9	-1.7	-0.6
Intermittent access intake escalation 2	4.7	4.7	9.8	3.1	-2.0	-0.7
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.7	0.9	0.3	0.3
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	0.8	-0.5	-0.0
Intermitt. access escalation Index	0.4	0.3	0.6	-0.6	-0.1	-0.8
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.2	0.2	0.0
Intermittent access day 15 total infusions	1.2	1.3	2.9	1.7	-1.0	-0.3
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.6	1.3	-0.8	-0.6
Intermittent access total infusions	0.1	0.1	0.4	0.6	-0.2	-0.0
Intermittent access day 1 locomotion	0.2	0.3	0.5	0.7	-0.5	-0.1
Intermittent access day 15 total locomotion	2.7	2.9	4.4	2.1	-1.8	-0.9
Intermittent access total locomotion	0.9	1.0	1.4	1.2	-1.0	-0.8
Intermittent access standard deviation	1.7	1.8	3.9	2.0	-1.2	-0.5
Cocaine induced anxiety	1.5	1.7	3.0	0.6	-1.3	-1.7
Post-drug Anxiety	1.0	1.1	1.8	0.3	-1.3	-1.3
Baseline Anxiety	0.3	0.3	0.8	0.3	0.0	0.9
Lifetime Intake	0.0	0.1	0.1	0.4	-0.1	-0.1
Incentive Sensitization - Responses	0.2	0.2	0.5	0.7	0.2	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	0.8	0.1	0.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	-0.1	0.5	0.8
Progressive ratio test 1 breakpoint	0.3	0.4	0.6	-0.3	0.6	0.8
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.2	-0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.7	0.1	0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.7	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	-0.2	-0.4
Total sessions with >9 infusions	0.1	0.1	0.4	-0.0	0.0	-0.6
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.2	-0.3	-0.1
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	0.2	0.0
Short access day 1 total infusions	0.4	0.5	0.8	0.1	-0.8	-0.9
Short access day 10 total infusions	0.1	0.1	0.2	0.3	0.2	0.5
Short access total infusions	0.0	0.0	0.0	0.1	-0.0	-0.2
Short access day 1 locomotion	1.2	1.3	1.6	0.9	-1.2	-1.3
Short access day 10 total locomotion	3.0	3.2	5.9	2.4	-1.7	-1.0
Short access total locomotion	0.9	0.9	1.2	1.1	-0.9	-0.9
Compulsive drug intake	0.6	0.6	1.2	-1.1	0.8	-0.1
One hour access (0.3 mA shock)	0.2	0.2	0.2	-0.4	0.5	0.5
One hour access (shock baseline)	0.2	0.2	0.4	0.4	0.2	0.7
Number of responses in last shaping day	0.1	0.1	0.2	0.5	-0.2	-0.3
Context. condit. distance diff. score	0.4	0.4	0.6	-0.6	0.8	0.6
Locomotion velocity, session 1	1.3	1.4	2.4	0.4	-1.3	-1.5
Locomotion distance, session 1	1.5	2.0	4.0	-0.2	-1.4	-2.0
Locomotion velocity, session 2	5.3	6.2	9.1	1.5	-3.0	-2.7
Locomotion distance, session 2	3.6	5.2	7.9	0.9	-2.6	-2.8
Locomotion velocity, session 3	4.3	5.0	7.2	2.7	-2.5	-1.2
Locomotion distance, session 3	0.1	0.1	0.1	0.0	0.3	0.4
Stereotopy head waving bouts, day 3	4.5	5.4	7.5	2.2	-2.7	-1.9
Stereotopy head waving duration, day 3	4.8	5.9	8.1	2.5	-2.8	-1.8
Locomotion velocity, session 7	0.4	0.5	0.7	0.8	-0.4	-0.8
Locomotion distance, session 7	0.5	0.6	1.0	-0.1	1.0	0.9
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	-0.3	-0.6	-1.0
Stereotopy head waving duration, day 7	0.9	1.1	2.2	0.1	-1.0	-1.5
Locomotion velocity, session 8	1.9	2.2	4.1	0.3	-1.6	-2.0
Locomotion distance, session 8	0.3	0.5	0.7	0.2	-0.8	-0.8
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.6	0.2
Degree of sensitization stereotypy	1.1	1.2	2.7	-1.6	1.0	0.0
Condit. Reinf. active minus inactive responses	3.2	3.6	4.9	2.1	-2.2	-1.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.7	1.6	-1.1	-0.2
Condit. Reinf. active responses	4.0	4.9	7.1	1.9	-2.7	-2.0
Condit. Reinf. inactive responses	2.0	2.4	3.4	0.6	-1.8	-1.9
Incentive salience index mean	2.4	2.9	4.2	1.4	-2.1	-1.6
Condit. Reinf. lever presses	1.2	1.6	3.5	-0.4	-1.1	-1.9
Time in familiar zone, hab. session 1	1.3	1.2	2.4	1.6	-1.1	-0.2
Time in novel zone, hab. session 1	0.7	0.7	1.4	-1.2	0.6	-0.5
Total zone transitions, hab. session 1	2.0	2.8	4.2	0.7	-1.9	-2.0
Total locomotion distance, hab. session 1	3.0	4.3	7.5	0.6	-2.2	-2.7
Locomotion velocity, hab. session 1	3.2	4.5	6.8	1.0	-2.4	-2.6
Time in familiar zone, hab. session 2	3.7	3.9	7.6	2.8	-1.9	-0.4
Time in novel zone, hab. session 2	2.8	2.9	5.7	-2.4	1.7	0.2
Total zone transitions, hab. session 2	1.1	1.5	2.8	-0.8	-1.0	-1.7
Total locomotion distance, hab. session 2	2.1	2.8	4.1	0.7	-2.0	-1.9
Locomotion velocity, hab. session 2	2.6	3.5	5.1	0.6	-2.2	-2.3
Novel to familiar place preference ratio	2.5	2.6	5.5	-2.3	1.5	-0.2
Novelty place preference	1.5	1.6	3.4	-1.9	1.1	-0.4
Time in novel zone, NPP test	1.7	1.8	3.9	-2.0	1.3	-0.2
Total zone transitions, NPP test	0.6	0.8	1.3	-0.3	-1.0	-1.1
Total locomotion distance, NPP test	0.6	0.8	1.7	-0.5	-0.8	-1.3
Locomotion velocity, NPP test	0.8	1.1	2.1	-0.2	-1.1	-1.4
Pavlov. Cond. lever latency	0.4	0.5	1.2	0.4	0.5	1.1
Pavlov. Cond. magazine entry latency	2.1	2.8	4.1	2.0	-1.9	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	-0.4	-0.3
Pavlov. Cond. index score	0.6	0.8	1.2	0.5	-1.1	-1.0
Pavlov. Cond. latency score	0.9	1.1	1.8	0.4	-1.2	-1.3
Pavlov. Cond. lever contacts	0.8	0.9	2.0	-0.2	-0.8	-1.4
Pavlov. Cond. magazine entry number	0.6	0.7	1.1	-0.9	1.1	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.6	0.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.7	0.8	-1.3	-1.1
Pavlov. Cond. response bias	0.9	1.1	1.7	1.1	-1.3	-0.7
Bone: apparent density	1.2	2.0	4.6	-0.6	-1.0	-2.1
Bone surface	2.8	5.0	11.1	-0.3	-2.0	-3.3
Bone volume	3.0	5.1	11.7	-0.3	-1.9	-3.4
Bone: connectivity density	0.6	0.9	1.6	-1.0	-0.3	-1.3
Bone: cortical apparent density	0.6	0.7	1.0	-1.0	0.9	0.6
Bone: cortical area	0.4	0.6	1.3	-1.1	0.5	-0.7
Bone: cortical porosity	1.0	1.1	1.7	0.6	-1.0	-1.3
Bone: cortical porosity	0.7	0.8	1.9	-0.1	-0.7	-1.4
Bone: cortical thickness	0.6	1.1	2.1	-1.5	1.0	0.1
Bone: cortical thickness	0.3	0.4	0.7	0.3	0.6	0.8
Bone: cortical tissue density	0.4	0.5	0.6	-0.8	0.7	0.6
Bone: elastic displacement	0.3	0.3	0.4	0.5	-0.6	-0.6
Bone: elastic work	0.2	0.2	0.4	-0.6	0.5	-0.3
Bone: endosteal estimation	0.1	0.3	0.6	-0.8	0.4	-0.0
Bone: endosteal perimeter	0.4	0.8	1.5	0.4	-0.9	-1.2
Bone: final force	0.8	1.3	2.6	-1.6	1.2	-0.2
Bone: final moment	0.6	1.0	2.1	-1.4	1.0	-0.2
Bone: marrow area	0.1	0.3	0.7	-0.8	0.5	0.0
Bone: maximum diameter	1.2	2.1	3.5	0.8	-1.5	-1.9
Bone: maximum force	0.9	1.5	2.6	-1.6	1.4	0.2
Bone: maximum moment	0.7	1.2	2.1	-1.5	1.2	0.1
Bone: minimum diameter	0.1	0.2	0.5	-0.3	-0.1	-0.7
Bone: periosteal estimation	0.3	0.6	1.1	-1.1	0.3	-0.7
Bone: periosteal perimeter	0.4	0.7	1.9	-0.0	-0.5	-1.4
Bone: post-yield work	0.6	0.8	1.1	-0.8	1.1	0.7
Bone: stiffness	2.2	3.5	5.5	-2.3	2.1	0.8
Bone: tissue strength	1.0	1.0	1.8	-1.4	1.0	0.4
Bone: trabecular number	1.4	2.2	3.7	0.6	-1.6	-1.9
Bone: trabecular spacing	2.5	3.3	6.5	-0.1	1.8	2.5
Bone: trabecular thickness	3.3	4.0	9.6	-0.7	-1.4	-3.1
Bone: trabecular tissue density	1.6	2.2	2.5	-1.4	1.6	1.5
Breakpoint value in progressive ratio session	3.7	4.1	7.1	2.7	-2.1	-0.8
Distance traveled before self-admin	0.2	0.2	0.4	-0.6	0.5	-0.3
Distance traveled after self-admin	0.8	0.8	1.1	0.8	-0.9	-1.1
Delta time in closed arm before/after self-admin	3.0	2.9	5.4	-0.3	1.8	2.3
Delta time in open arm before/after self-admin	0.7	0.7	1.5	-1.2	0.8	0.2
Diff in mean of infusions in LGA sessions	1.3	1.5	2.3	1.3	-1.5	-0.6
Extinction: sum of active levers before priming	0.9	0.9	2.3	1.5	-0.6	0.2
Active lever presses in extinction session 6	2.7	2.6	2.8	1.7	-1.6	-1.5
Delta distance traveled before/after self-admin	1.2	1.3	1.8	1.2	-1.4	-0.9
Delta ambulatory time before/after self-admin	1.4	1.6	2.3	1.2	-1.5	-1.0
Time in closed arm before self-admin	0.6	0.7	1.4	-1.2	0.1	-0.7
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	-0.0	0.3
Time in open arm before self-admin	0.6	0.6	1.3	1.2	-0.6	-0.4
Time in open arm after self-admin	0.6	0.6	1.0	-0.8	1.0	0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1	-0.1
Time to tail flick, vehicle, before self-admin	1.1	1.1	1.8	0.4	-1.1	-1.3
Time to tail flick, vehicle, after self-admin	0.5	0.6	1.4	0.5	0.2	1.2
Time to tail flick, test, before self-admin	0.7	0.7	1.4	0.2	-0.8	-1.2
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.3	-0.8	-0.6
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.8	-0.3	1.3	2.0
Delta time to tail flick, test, before/after SA	0.3	0.2	0.5	0.4	-0.0	0.7
Ambulatory time before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.3
Ambulatory time after self-admin	0.5	0.5	0.7	0.6	-0.7	-0.9
Total heroin consumption	1.6	1.9	2.4	1.6	-1.6	-1.0
Area under the delay curve	1.7	1.9	2.6	-1.6	1.6	0.6
Delay disc. indifference point, 0s delay	4.0	4.3	10.1	-3.2	1.7	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.4	0.3	0.2
Delay disc. indifference point, 2s delay	3.8	4.2	7.6	-2.8	2.1	0.7
Delay disc. indifference point, 24s delay	0.7	0.7	1.2	-0.7	1.1	0.6
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	-1.2	0.8	0.1
Delay disc. indifference point, 8s delay	1.5	1.5	2.6	-1.0	1.6	1.0
Delay discount exponential model param	1.7	1.8	2.5	1.5	-1.6	-0.7
Delay discount hyperbolic model param	2.3	2.4	3.4	1.8	-1.8	-0.7
Fecal boli incidents, locomotor time 1	1.6	1.8	2.5	-1.2	1.6	1.2
Change in fecal boli incidents, locomotor task	0.6	0.5	1.4	0.3	-0.4	-1.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.2	-0.7	0.4	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	-0.2	-0.0
Total resting periods, locomotor time 1	0.1	0.2	0.3	0.5	-0.4	-0.3
Rest time, locomotor task time 1	0.3	0.3	0.5	0.4	-0.7	-0.5
Distance moved, locomotor task time 1	0.5	0.5	0.7	-0.8	0.3	-0.9
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.2	0.9	0.4
Time >=10cm from walls, locomotor time 2	1.3	1.4	2.8	-0.9	1.7	0.7
Bouts of movement, locomotor time 2	1.0	1.1	1.7	0.4	-1.3	-1.2
Total resting periods, locomotor time 2	1.0	1.1	1.6	0.3	-1.3	-1.3
Rest time, locomotor task time 2	0.8	0.9	1.2	0.6	-1.1	-1.1
Distance moved, locomotor task time 2	0.8	1.0	1.2	-0.8	1.1	1.0
Vertical activity count, locomotor time 2	1.4	1.6	2.2	-0.6	1.5	1.5
Weight adjusted by age	1.0	1.1	1.7	-0.2	1.2	1.3
Seeking ratio, delayed vs. immediate footshock	4.2	4.8	5.8	2.2	-2.4	-1.9
Locomotion in novel chamber	0.2	0.2	0.6	0.8	-0.3	0.0
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	1.0	-0.7	-0.2
Progressive ratio	0.3	0.4	0.8	-0.4	0.4	0.9
Food seeking constrained by brief footshock	0.2	0.3	0.8	0.3	-0.9	-0.2
Seeking ratio, punishment vs. effort	0.4	0.4	0.6	0.3	-0.8	-0.8
Run reversals in cocaine runway, females	0.4	0.4	0.5	0.5	-0.7	-0.6
Run reversals in cocaine runway, males	1.3	1.3	2.2	1.0	-1.5	-0.9
Latency to leave start box in cocaine runway	2.1	2.3	4.3	0.8	-1.4	-2.1
Latency to leave start box in cocaine runway, F	1.5	1.7	4.5	-0.2	-0.7	-2.1
Latency to leave start box in cocaine runway, M	1.7	1.6	3.7	1.9	-1.0	-0.0
Cd content in liver	0.1	0.1	0.3	-0.5	0.3	-0.1
Co content in liver	0.4	0.4	0.7	0.9	-0.7	-0.3
Cu content in liver	0.4	0.4	1.0	-0.6	-0.2	-1.0
Fe content in liver	0.1	0.1	0.2	0.3	0.1	0.5
K content in liver	0.6	0.6	1.4	-0.3	-0.6	-1.2
Mg content in liver	0.7	0.7	1.6	-0.4	-0.6	-1.3
Mn content in liver	3.1	3.6	7.0	0.4	-1.9	-2.7
Na content in liver	0.6	0.7	1.6	-1.3	0.3	-0.5
Rb content in liver	0.4	0.6	0.8	-0.9	-0.0	-0.9
Se content in liver	0.2	0.2	0.3	0.4	-0.6	-0.4
Sr content in liver	0.4	0.4	0.9	0.3	0.4	0.9
Zn content in liver	1.3	1.4	3.2	1.8	-0.5	0.8