Hub : Genes

Rexo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000017916	0.09	0.06	1.5e-08	0.08	0.07	0.06	0.08	3.6e-08	3.9e-07	1.4e-06	1.4e-07
2	Brain	mRNA stability	ENSRNOG00000017916	0.05	0.04	7.3e-05	0.03	0.04	0.04	0.04	1.5e-03	1.1e-04	9.1e-05	3.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	5.8	18.7	20.7	-4.6	4.1
BMI without tail	1.6	3.4	3.9	-2.0	1.7
Body weight	1.0	4.3	4.8	-2.2	1.9
Epididymis fat weight	0.1	0.3	0.7	0.8	-0.1
Glucose	1.1	1.7	1.9	-1.4	1.3
Heart weight	0.4	0.5	0.7	0.8	-0.6
Left kidney weight	0.0	0.0	0.0	0.0	-0.2
Right kidney weight	1.3	3.6	3.8	1.9	-1.8
Tail length	2.9	8.8	10.6	3.3	-2.6
Length with tail	1.6	6.0	6.5	2.5	-2.3
Length without tail	0.0	0.0	0.1	-0.0	-0.2
Liver weight, left	2.6	4.2	4.6	-1.9	2.1
Liver weight, right	1.9	3.1	3.2	-1.8	1.8
Parametrial fat weight	0.5	1.0	1.0	1.0	-1.0
Retroperitoneal fat weight	0.2	0.8	0.8	-0.9	0.9
Intraocular pressure	0.1	0.2	0.2	0.5	-0.4
Extensor digitorum longus weight	3.2	13.0	15.6	-3.9	3.2
Soleus weight	7.2	21.0	26.7	-5.2	3.9
Tibialis anterior weight	0.9	3.2	3.9	-2.0	1.6
Tibia length	0.8	2.3	2.8	1.7	-1.3
Number of licking bursts	0.0	0.0	0.0	0.2	-0.0
Food consumed during 24 hour testing period	0.3	0.3	0.5	-0.7	0.4
Times rat made contact with spout	0.0	0.0	0.1	-0.3	-0.0
Mean time between licks in bursts	3.7	5.2	6.5	2.6	-2.0
Mean num. licks in bursts	0.0	0.0	0.1	-0.3	-0.1
Std. dev. time between licks in bursts	0.7	0.8	1.0	0.8	-1.0
Water consumed over 24 hours	0.5	0.6	1.0	-1.0	0.5
Indifference point 0 sec	0.2	0.2	0.3	-0.5	0.5
Indifference point AUC	0.8	0.9	1.4	1.2	-0.7
Indifference point function ln k	0.1	0.2	0.3	-0.6	-0.1
Indifference point function log k	0.1	0.2	0.3	-0.6	-0.1
Delay discounting total patch changes 0 sec	0.1	0.2	0.2	-0.4	0.4
Delay discounting total patch changes 12 sec	0.4	0.5	0.9	-0.4	1.0
Delay discounting total patch changes 18 sec	0.8	1.0	1.5	1.2	-0.7
Delay discounting total patch changes 24 sec	0.0	0.0	0.1	0.3	0.1
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	0.6	-0.2
Delay discounting time to switch 0 sec	2.4	3.7	4.1	-1.8	2.0
Delay discounting water rate 0 sec	0.4	0.6	0.8	0.6	-0.9
Delay discounting water rate 12 sec	0.3	0.5	0.6	-0.8	0.6
Delay discounting water rate 18 sec	0.6	0.8	1.0	1.0	-0.8
Delay discounting water rate 24 sec	0.0	0.0	0.0	0.1	-0.2
Delay discounting water rate 6 sec	0.7	1.1	1.2	1.1	-1.0
Locomotor activity	2.2	3.6	4.3	2.1	-1.7
Locomotor testing distance	1.4	2.4	3.0	1.7	-1.3
Locomotor testing rearing	0.0	0.1	0.1	0.3	-0.3
Light reinforcement 1	4.3	7.9	9.7	3.1	-2.5
Light reinforcement 2	1.9	2.5	2.6	1.5	-1.6
Reaction time number correct	0.1	0.1	0.3	-0.5	-0.1
Reaction time mean minus median	1.0	1.3	1.4	1.1	-1.2
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	-0.2
Reaction time num false alarms	0.1	0.2	0.4	-0.0	-0.6
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.1	-0.5
Reaction time trials correct on left	0.1	0.1	0.3	-0.5	-0.1
Reaction time trials on left	0.1	0.1	0.3	-0.5	-0.0
Reaction time mean	0.0	0.0	0.0	-0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.1	-0.3	-0.0
Median of all reaction times	0.3	0.4	0.6	-0.7	0.5
Reaction time omissions	0.2	0.3	0.4	0.6	-0.5
Reaction time false alarm rate	0.0	0.0	0.1	-0.1	-0.2
Reaction time premature initiation rate	1.2	1.6	2.0	1.4	-1.1
Reaction time premature initiations	1.1	1.5	1.5	1.2	-1.2
Std. dev. reaction times	0.3	0.5	0.7	0.5	-0.8
Reaction time trials completed	0.1	0.1	0.3	-0.5	-0.0
Reaction time trials AUC	0.1	0.1	0.2	-0.4	-0.1
Social response proportion	0.2	0.2	0.4	0.6	-0.2
Social responses	5.5	7.2	8.1	2.8	-2.5
Social time	1.3	1.8	2.7	-0.9	1.6
Conditioned locomotion	0.8	1.0	1.2	-1.1	0.9
Cocaine response after cond. corrected	2.7	3.0	4.1	-2.0	1.4
Cocaine response after cond. not corrected	2.8	3.1	4.4	-2.1	1.3
Cocaine response before conditioning	0.5	0.6	0.8	0.6	-0.9
Saline control response	0.1	0.2	0.3	-0.2	0.5
Condit. Reinf. active minus inactive responses	2.8	3.5	3.8	1.9	-1.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.7	-0.1
Condit. Reinf. active responses	2.8	3.9	4.4	1.9	-2.1
Condit. Reinf. inactive responses	1.9	2.3	3.4	1.1	-1.8
Condit. Reinf. lever presses	2.6	3.6	3.9	2.0	-1.8
Condit. Reinf. lever reinforcers received	2.4	3.4	3.9	1.7	-2.0
Pavlov. Cond. lever latency	1.3	1.8	2.5	-1.0	1.6
Pavlov. Cond. magazine entry latency	0.7	0.7	1.0	0.7	-1.0
Pavlov. Cond. change in total contacts	1.1	1.6	1.9	1.1	-1.4
Pavlov. Cond. index score	1.3	1.7	2.2	1.1	-1.5
Pavlov. Cond. latency score	1.2	1.5	1.9	1.0	-1.4
Pavlov. Cond. lever contacts	1.3	1.8	2.4	1.1	-1.5
Pavlov. Cond. magazine entry number	1.0	1.2	1.5	-1.0	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.0	1.1	-1.4
Pavlov. Cond. response bias	2.5	3.5	4.1	1.7	-2.0
Conditioned reinforcement - actives	2.7	2.7	2.8	1.7	-1.6
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.6	0.1
Conditioned locomotion	7.4	8.9	10.5	3.2	-2.7
Intermittent access intake day 1-15 change	6.7	6.7	8.0	2.8	-2.3
Intermittent access intake escalation	7.0	6.9	8.6	2.9	-2.3
Intermittent access intake escalation 2	8.0	7.9	10.2	3.2	-2.4
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.8	0.9	-0.6
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	0.8	-0.9
Intermitt. access escalation Index	0.3	0.3	0.4	-0.7	0.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	-0.0
Intermittent access day 15 total infusions	2.4	2.7	2.8	1.7	-1.6
Intermittent access terminal intake (last 3 days)	1.4	1.5	1.5	1.2	-1.2
Intermittent access total infusions	0.4	0.4	0.6	0.6	-0.8
Intermittent access day 1 locomotion	0.6	0.6	0.8	0.6	-0.9
Intermittent access day 15 total locomotion	3.7	4.0	4.6	2.2	-1.8
Intermittent access total locomotion	1.2	1.3	1.4	1.2	-1.1
Intermittent access standard deviation	3.7	3.9	4.3	2.1	-1.9
Cocaine induced anxiety	0.2	0.2	0.4	0.6	-0.3
Post-drug Anxiety	0.1	0.1	0.1	0.3	-0.2
Baseline Anxiety	0.2	0.2	0.3	0.3	-0.5
Lifetime Intake	0.2	0.2	0.3	0.3	-0.6
Incentive Sensitization - Responses	0.4	0.4	0.6	0.8	-0.4
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	0.8	-0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.2	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	-0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.1	-0.5
Progressive ratio test 2 active lever presses	0.4	0.5	0.5	0.7	-0.7
Progressive ratio test 2 breakpoint	0.5	0.5	0.6	0.7	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.2	-0.3
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.2	-0.5
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	0.1
Short access day 1 total infusions	0.2	0.2	0.4	0.1	-0.6
Short access day 10 total infusions	0.3	0.3	0.7	0.2	-0.8
Short access total infusions	0.0	0.0	0.1	-0.0	-0.3
Short access day 1 locomotion	1.3	1.4	2.0	0.9	-1.4
Short access day 10 total locomotion	5.1	5.6	5.7	2.4	-2.3
Short access total locomotion	1.3	1.3	1.7	1.0	-1.3
Compulsive drug intake	1.4	1.4	1.5	-1.2	1.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	-0.1
One hour access (shock baseline)	0.5	0.6	1.0	0.4	-1.0
Number of responses in last shaping day	0.4	0.4	0.6	0.4	-0.8
Context. condit. distance diff. score	0.1	0.2	0.3	-0.6	0.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.2
Locomotion distance, session 1	0.3	0.4	0.7	-0.2	0.8
Locomotion velocity, session 2	1.3	1.5	2.3	1.5	-0.8
Locomotion distance, session 2	0.3	0.4	0.9	0.9	0.0
Locomotion velocity, session 3	5.7	6.7	7.2	2.7	-2.5
Locomotion distance, session 3	0.1	0.1	0.1	0.0	-0.3
Stereotopy head waving bouts, day 3	3.0	3.6	4.9	2.2	-1.5
Stereotopy head waving duration, day 3	4.1	5.0	6.3	2.5	-1.9
Locomotion velocity, session 7	1.3	1.5	2.2	0.8	-1.5
Locomotion distance, session 7	0.1	0.1	0.1	-0.1	-0.4
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	-0.3	0.2
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	-0.1
Locomotion distance, session 8	0.0	0.1	0.1	0.2	0.3
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.5
Degree of sensitization stereotypy	1.8	1.9	2.7	-1.6	1.1
Condit. Reinf. active minus inactive responses	3.6	4.0	4.5	2.1	-1.9
Condit. Reinf. active-inactive response ratio	2.6	2.8	2.9	1.6	-1.7
Condit. Reinf. active responses	2.0	2.5	3.5	1.9	-1.2
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.6	0.2
Incentive salience index mean	1.2	1.5	1.9	1.4	-1.0
Condit. Reinf. lever presses	0.4	0.5	0.9	-0.4	0.9
Time in familiar zone, hab. session 1	2.7	2.5	2.6	1.6	-1.6
Time in novel zone, hab. session 1	1.1	1.0	1.4	-1.2	0.8
Total zone transitions, hab. session 1	0.2	0.3	0.6	0.7	-0.2
Total locomotion distance, hab. session 1	0.2	0.2	0.4	0.6	-0.3
Locomotion velocity, hab. session 1	0.3	0.5	0.9	1.0	-0.3
Time in familiar zone, hab. session 2	6.6	6.9	7.6	2.8	-2.5
Time in novel zone, hab. session 2	4.6	4.6	5.7	-2.4	1.9
Total zone transitions, hab. session 2	1.2	1.6	2.5	-0.8	1.6
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.7	0.1
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.6	0.4
Novel to familiar place preference ratio	4.5	4.7	5.5	-2.3	2.0
Novelty place preference	2.8	2.9	3.4	-1.9	1.5
Time in novel zone, NPP test	3.0	3.2	3.9	-2.0	1.6
Total zone transitions, NPP test	0.7	0.9	1.8	-0.3	1.3
Total locomotion distance, NPP test	0.5	0.7	1.1	-0.5	1.1
Locomotion velocity, NPP test	0.3	0.4	0.8	-0.2	0.9
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.4	-0.5
Pavlov. Cond. magazine entry latency	2.4	3.1	4.1	2.0	-1.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	0.1
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.9	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.3	0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	0.6	0.8	-0.5
Pavlov. Cond. response bias	0.8	1.0	1.3	1.1	-0.8
Bone: apparent density	0.1	0.2	0.4	-0.6	0.2
Bone surface	0.1	0.1	0.1	-0.3	-0.3
Bone volume	0.1	0.1	0.1	-0.3	-0.4
Bone: connectivity density	0.4	0.6	0.9	-1.0	0.4
Bone: cortical apparent density	0.7	0.9	1.0	-1.0	0.9
Bone: cortical area	0.5	0.7	1.3	-1.1	0.3
Bone: cortical porosity	0.3	0.3	0.4	0.6	-0.5
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.0
Bone: cortical thickness	0.9	1.6	2.1	-1.5	1.0
Bone: cortical thickness	0.1	0.1	0.2	0.3	-0.4
Bone: cortical tissue density	0.4	0.6	0.6	-0.8	0.7
Bone: elastic displacement	0.2	0.2	0.2	0.5	-0.5
Bone: elastic work	0.1	0.2	0.4	-0.6	-0.1
Bone: endosteal estimation	0.2	0.3	0.6	-0.8	0.2
Bone: endosteal perimeter	0.2	0.4	0.7	0.4	-0.8
Bone: final force	1.0	1.6	2.6	-1.6	0.8
Bone: final moment	0.7	1.2	2.1	-1.4	0.6
Bone: marrow area	0.2	0.4	0.7	-0.8	0.3
Bone: maximum diameter	0.5	0.9	1.2	0.8	-1.1
Bone: maximum force	0.9	1.5	2.6	-1.6	0.7
Bone: maximum moment	0.7	1.2	2.1	-1.5	0.5
Bone: minimum diameter	0.0	0.1	0.1	-0.3	-0.2
Bone: periosteal estimation	0.3	0.6	1.1	-1.1	0.2
Bone: periosteal perimeter	0.1	0.1	0.3	-0.0	-0.5
Bone: post-yield work	0.3	0.4	0.7	-0.8	0.4
Bone: stiffness	2.4	3.8	5.5	-2.3	1.4
Bone: tissue strength	1.8	1.7	1.8	-1.4	1.3
Bone: trabecular number	0.4	0.5	0.8	0.6	-0.9
Bone: trabecular spacing	0.1	0.1	0.2	-0.1	0.5
Bone: trabecular thickness	0.2	0.3	0.5	-0.7	0.3
Bone: trabecular tissue density	1.7	2.4	3.0	-1.4	1.7
Breakpoint value in progressive ratio session	4.9	5.4	7.2	2.7	-1.9
Distance traveled before self-admin	0.4	0.4	0.5	-0.6	0.7
Distance traveled after self-admin	0.5	0.5	0.8	0.9	-0.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.3	0.1
Delta time in open arm before/after self-admin	1.4	1.4	1.5	-1.2	1.1
Diff in mean of infusions in LGA sessions	1.3	1.4	2.0	1.4	-0.9
Extinction: sum of active levers before priming	1.3	1.3	2.0	1.4	-0.8
Active lever presses in extinction session 6	2.4	2.3	3.3	1.8	-1.1
Delta distance traveled before/after self-admin	1.4	1.5	1.6	1.3	-1.1
Delta ambulatory time before/after self-admin	1.4	1.6	1.6	1.3	-1.2
Time in closed arm before self-admin	1.3	1.4	1.5	-1.2	1.2
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	-0.1
Time in open arm before self-admin	1.1	1.2	1.5	1.2	-0.9
Time in open arm after self-admin	0.5	0.6	0.6	-0.7	0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	0.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	0.5	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.2	0.4	-0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.2	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.4	0.3
Delta time to tail flick, test, before/after SA	0.4	0.3	0.4	0.5	-0.7
Ambulatory time before self-admin	0.3	0.3	0.4	-0.5	0.7
Ambulatory time after self-admin	0.3	0.3	0.4	0.7	-0.4
Total heroin consumption	1.4	1.7	2.5	1.6	-0.9
Area under the delay curve	1.8	1.9	2.6	-1.6	1.1
Delay disc. indifference point, 0s delay	8.6	9.3	10.1	-3.2	2.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.4	0.2
Delay disc. indifference point, 2s delay	5.5	6.2	7.6	-2.8	2.2
Delay disc. indifference point, 24s delay	0.5	0.5	0.6	-0.7	0.8
Delay disc. indifference point, 4s delay	0.9	1.0	1.5	-1.2	0.6
Delay disc. indifference point, 8s delay	0.6	0.6	1.0	-1.0	0.6
Delay discount exponential model param	1.6	1.6	2.3	1.5	-1.0
Delay discount hyperbolic model param	2.3	2.4	3.4	1.8	-1.2
Fecal boli incidents, locomotor time 1	1.3	1.4	1.5	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.3	-0.6
Time >=10cm from walls, locomotor time 1	0.7	0.8	1.0	-0.7	1.0
Bouts of movement, locomotor time 1	0.2	0.3	0.3	0.5	-0.5
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.5	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.1	0.4	-0.3
Distance moved, locomotor task time 1	0.7	0.8	0.9	-0.8	0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.0	-0.9	1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.4	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.1	0.3	-0.3
Rest time, locomotor task time 2	0.3	0.4	0.4	0.6	-0.6
Distance moved, locomotor task time 2	0.7	0.8	0.9	-0.8	1.0
Vertical activity count, locomotor time 2	0.3	0.3	0.4	-0.6	0.5
Weight adjusted by age	0.0	0.0	0.1	-0.3	-0.0
Seeking ratio, delayed vs. immediate footshock	3.7	4.3	5.0	2.2	-1.9
Locomotion in novel chamber	0.3	0.3	0.6	0.8	-0.2
Locomotion in novel chamber post-restriction	1.1	1.3	1.8	1.0	-1.3
Progressive ratio	0.5	0.6	1.0	-0.4	1.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	0.4
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	0.3	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.3	0.5	-0.5
Run reversals in cocaine runway, males	0.9	0.9	0.9	0.9	-0.9
Latency to leave start box in cocaine runway	0.4	0.5	0.7	0.9	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	0.6
Latency to leave start box in cocaine runway, M	3.2	3.0	3.8	2.0	-1.5
Cd content in liver	0.2	0.2	0.3	-0.5	0.4
Co content in liver	0.5	0.6	0.9	0.9	-0.6
Cu content in liver	0.2	0.2	0.3	-0.5	0.4
Fe content in liver	0.0	0.0	0.1	0.2	-0.2
K content in liver	0.2	0.2	0.4	-0.2	0.6
Mg content in liver	0.2	0.2	0.3	-0.3	0.6
Mn content in liver	0.3	0.3	0.5	0.5	-0.7
Na content in liver	1.6	1.7	1.9	-1.2	1.4
Rb content in liver	0.5	0.6	0.8	-0.9	0.6
Se content in liver	0.1	0.1	0.1	0.4	-0.4
Sr content in liver	0.1	0.1	0.1	0.3	-0.4
Zn content in liver	2.4	2.7	3.6	1.9	-1.3