Hub : Genes

Ercc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000017753 0.28 0.16 0.0e+00 0.26 0.26 0.26 0.26 8.5e-29 3.3e-29 3.2e-29 2.5e-29
2 Adipose isoform ratio ENSRNOT00000024246 0.03 0.03 3.0e-03 0.02 0.02 0.01 0.02 1.9e-03 2.8e-03 2.2e-02 4.1e-03
3 Adipose mRNA stability ENSRNOG00000017753 0.04 0.04 6.7e-05 0.03 0.03 0.03 0.03 1.4e-04 1.1e-04 1.7e-04 1.7e-04
4 BLA gene expression ENSRNOG00000017753 0.28 0.16 1.2e-15 0.22 0.23 0.22 0.22 4.8e-12 2.4e-12 5.6e-12 5.5e-12
5 Brain gene expression ENSRNOG00000017753 0.32 0.15 0.0e+00 0.4 0.41 0.41 0.41 1.8e-39 1.3e-40 4.0e-40 3.9e-40
6 Brain mRNA stability ENSRNOG00000017753 0.16 0.18 4.2e-07 0.07 0.07 0.09 0.09 4.0e-07 2.1e-07 2.1e-08 1.8e-08
7 IL gene expression ENSRNOG00000017753 0.15 0.13 4.4e-03 0.08 0.08 0.08 0.07 6.0e-03 5.1e-03 5.9e-03 7.6e-03
8 LHb gene expression ENSRNOG00000017753 0.24 0.16 5.8e-05 0.22 0.22 0.2 0.2 6.6e-06 5.7e-06 1.5e-05 1.4e-05
9 Liver gene expression ENSRNOG00000017753 0.33 0.17 0.0e+00 0.31 0.32 0.31 0.32 3.3e-35 8.0e-37 5.5e-35 6.7e-36
10 Liver mRNA stability ENSRNOG00000017753 0.1 0.08 1.2e-09 0.07 0.07 0.06 0.07 4.6e-08 2.0e-08 2.9e-07 6.5e-08
11 NAcc gene expression ENSRNOG00000017753 0.25 0.14 0.0e+00 0.27 0.27 0.26 0.26 5.5e-20 3.8e-20 2.7e-19 2.3e-19
12 NAcc mRNA stability ENSRNOG00000017753 0.03 0.03 8.4e-03 0.02 0.01 0 0.01 1.5e-02 2.6e-02 1.2e-01 2.9e-02
13 OFC gene expression ENSRNOG00000017753 0.24 0.18 1.7e-04 0.22 0.16 0.16 0.18 4.5e-06 1.4e-04 1.4e-04 3.6e-05
14 PL gene expression ENSRNOG00000017753 0.33 0.18 0.0e+00 0.3 0.3 0.3 0.3 2.1e-23 4.7e-23 4.7e-23 1.4e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
BMI with tail0.61.92.2-1.3-1.1-1.4-1.4-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.5-1.4-1.4
BMI without tail0.91.82.0-1.3-1.1-1.4-1.4-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.3-1.4-1.4
Body weight0.73.13.5-1.7-1.6-1.8-1.8-1.8-1.9-1.8-1.8-1.8-1.8-1.8-1.8-1.7-1.8
Epididymis fat weight0.82.02.31.41.41.41.41.41.51.41.41.41.41.41.31.41.4
Glucose0.30.40.70.70.70.60.60.60.80.60.60.60.60.60.70.60.6
Heart weight3.34.75.8-2.2-2.3-2.2-2.1-2.1-2.4-2.2-2.2-2.1-2.2-2.1-2.3-2.1-2.1
Left kidney weight7.922.628.0-4.7-4.7-4.8-4.7-4.7-5.3-4.7-4.8-4.7-4.7-4.7-4.8-4.6-4.6
Right kidney weight6.117.420.8-4.1-4.1-4.2-4.1-4.1-4.6-4.2-4.2-4.2-4.2-4.1-4.2-4.1-4.1
Tail length0.00.10.2-0.2-0.2-0.2-0.2-0.2-0.5-0.2-0.2-0.3-0.2-0.3-0.1-0.2-0.2
Length with tail0.20.71.2-0.8-0.8-0.8-0.8-0.8-1.1-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.8
Length without tail0.10.30.5-0.5-0.5-0.6-0.5-0.6-0.7-0.6-0.6-0.5-0.6-0.5-0.7-0.5-0.5
Liver weight, left9.815.818.4-4.0-3.9-4.0-3.9-3.9-4.3-3.9-4.0-3.9-3.9-3.9-4.1-3.9-4.0
Liver weight, right2.23.75.0-1.9-2.1-1.9-1.8-1.9-2.2-1.9-1.9-1.8-1.9-1.8-2.2-1.7-1.8
Parametrial fat weight0.10.10.2-0.4-0.4-0.3-0.3-0.3-0.1-0.3-0.3-0.3-0.2-0.3-0.2-0.5-0.4
Retroperitoneal fat weight0.00.10.30.20.30.30.30.30.50.30.30.30.30.30.40.30.3
Intraocular pressure0.00.00.00.10.10.00.10.00.10.10.00.10.00.1-0.20.10.1
Extensor digitorum longus weight1.56.27.8-2.5-2.4-2.4-2.5-2.4-2.8-2.5-2.5-2.4-2.4-2.5-2.5-2.6-2.5
Soleus weight0.10.20.3-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.5
Tibialis anterior weight3.411.614.6-3.4-3.4-3.4-3.3-3.4-3.8-3.4-3.4-3.4-3.3-3.4-3.4-3.4-3.4
Tibia length0.20.70.8-0.6-0.6-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.7-0.7-0.8
Number of licking bursts2.73.24.1-1.8-1.4-1.8-1.9-1.8-1.6-1.8-1.8-1.9-1.8-1.9-1.4-2.0-1.9
Food consumed during 24 hour testing period5.66.77.42.62.42.62.72.62.62.62.62.62.62.72.42.72.7
Times rat made contact with spout0.00.00.0-0.0-0.20.00.10.0-0.20.00.00.10.00.1-0.20.20.1
Mean time between licks in bursts0.00.10.10.20.30.30.20.30.30.30.30.30.30.30.30.30.2
Mean num. licks in bursts2.63.14.51.71.31.72.01.81.51.81.71.91.71.91.32.11.9
Std. dev. time between licks in bursts0.00.00.1-0.1-0.2-0.10.0-0.0-0.3-0.0-0.1-0.0-0.1-0.0-0.20.1-0.1
Water consumed over 24 hours0.10.20.30.40.20.40.50.40.20.40.40.50.40.50.20.60.5
Indifference point 0 sec0.40.60.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.8
Indifference point AUC3.23.74.2-1.9-1.8-1.9-2.0-1.9-2.0-1.9-1.9-2.0-1.9-2.0-1.7-2.0-1.9
Indifference point function ln k0.91.21.61.00.91.11.21.11.01.11.11.21.11.20.91.31.1
Indifference point function log k0.91.21.61.00.91.11.21.11.01.11.11.21.11.20.91.31.1
Delay discounting total patch changes 0 sec0.61.01.3-1.1-1.1-1.0-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.0-0.9-1.0
Delay discounting total patch changes 12 sec1.21.61.9-1.2-1.1-1.3-1.3-1.3-1.2-1.3-1.2-1.3-1.3-1.3-1.1-1.4-1.3
Delay discounting total patch changes 18 sec2.12.83.6-1.7-1.7-1.6-1.6-1.6-1.9-1.7-1.7-1.6-1.6-1.6-1.7-1.6-1.6
Delay discounting total patch changes 24 sec0.20.30.4-0.6-0.6-0.5-0.5-0.5-0.7-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.5
Delay discounting total patch changes 6 sec2.33.64.4-1.9-1.9-1.9-1.9-1.9-2.1-1.9-1.9-1.9-1.9-1.9-1.7-1.9-1.9
Delay discounting time to switch 0 sec4.06.28.52.42.52.52.42.52.92.52.52.42.52.42.72.32.3
Delay discounting water rate 0 sec4.36.98.8-2.6-2.7-2.6-2.6-2.6-3.0-2.6-2.6-2.6-2.6-2.6-2.7-2.5-2.6
Delay discounting water rate 12 sec0.30.41.0-0.6-0.8-0.6-0.5-0.6-1.0-0.6-0.6-0.6-0.6-0.5-0.8-0.4-0.5
Delay discounting water rate 18 sec0.10.20.5-0.4-0.6-0.4-0.3-0.4-0.7-0.4-0.4-0.4-0.4-0.4-0.5-0.3-0.4
Delay discounting water rate 24 sec0.60.81.4-0.9-1.0-0.9-0.9-0.9-1.2-0.9-0.9-0.9-0.9-0.9-1.0-0.8-0.8
Delay discounting water rate 6 sec0.71.11.7-1.0-1.2-1.0-0.9-1.0-1.3-1.0-1.0-1.0-1.0-0.9-1.2-0.8-0.9
Locomotor activity2.13.43.9-1.8-1.7-1.8-1.9-1.8-2.0-1.8-1.8-1.9-1.8-1.9-1.5-2.0-1.9
Locomotor testing distance0.81.31.6-1.1-1.0-1.1-1.2-1.1-1.3-1.1-1.1-1.2-1.1-1.2-0.9-1.3-1.2
Locomotor testing rearing5.28.18.8-2.9-2.7-2.8-2.9-2.8-3.0-2.9-2.8-2.9-2.8-2.9-2.7-2.9-2.9
Light reinforcement 10.10.10.3-0.4-0.6-0.3-0.2-0.3-0.5-0.3-0.3-0.3-0.3-0.2-0.4-0.2-0.3
Light reinforcement 20.00.10.2-0.3-0.5-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.2
Reaction time number correct5.57.99.9-2.8-2.7-2.8-2.8-2.8-3.1-2.8-2.8-2.8-2.8-2.8-2.8-2.7-2.8
Reaction time mean minus median0.10.10.20.40.20.20.30.20.40.30.20.30.20.30.20.30.5
Reaction time mean minus median AUC0.20.20.4-0.3-0.5-0.5-0.4-0.5-0.4-0.5-0.5-0.4-0.5-0.4-0.6-0.4-0.2
Reaction time num false alarms4.25.87.0-2.4-2.5-2.4-2.3-2.4-2.6-2.4-2.4-2.4-2.4-2.4-2.4-2.3-2.4
Reaction time num false alarms AUC3.44.75.6-2.2-2.2-2.1-2.1-2.1-2.4-2.2-2.2-2.1-2.1-2.2-2.1-2.1-2.2
Reaction time trials correct on left5.57.99.9-2.8-2.7-2.8-2.8-2.8-3.1-2.8-2.8-2.8-2.8-2.8-2.8-2.7-2.8
Reaction time trials on left5.57.89.9-2.8-2.7-2.8-2.8-2.8-3.1-2.8-2.8-2.8-2.8-2.8-2.8-2.7-2.8
Reaction time mean1.31.72.21.41.11.31.41.31.41.31.31.41.21.41.11.41.5
Reaction time mean AUC1.01.31.71.20.81.11.21.11.21.11.11.21.11.21.01.21.3
Median of all reaction times1.72.32.81.51.21.51.61.51.71.51.51.61.51.61.41.61.6
Reaction time omissions0.00.10.1-0.2-0.4-0.3-0.2-0.3-0.3-0.2-0.3-0.2-0.3-0.2-0.4-0.1-0.1
Reaction time false alarm rate0.10.10.1-0.3-0.4-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3
Reaction time premature initiation rate0.50.60.80.80.70.80.80.80.70.80.80.80.80.80.70.90.8
Reaction time premature initiations0.30.40.8-0.7-0.7-0.7-0.6-0.7-0.9-0.6-0.7-0.6-0.6-0.6-0.7-0.5-0.6
Std. dev. reaction times0.20.30.50.60.40.50.60.50.70.50.50.50.50.60.40.50.7
Reaction time trials completed5.57.89.9-2.8-2.7-2.8-2.8-2.8-3.1-2.8-2.8-2.8-2.8-2.8-2.8-2.7-2.8
Reaction time trials AUC6.79.512.0-3.1-3.0-3.1-3.1-3.1-3.5-3.1-3.1-3.1-3.1-3.1-3.1-3.0-3.1
Social response proportion1.31.41.8-1.2-1.4-1.2-1.1-1.2-1.3-1.1-1.2-1.1-1.2-1.1-1.4-1.0-1.1
Social responses0.81.01.1-1.0-1.1-1.0-0.9-1.0-1.0-1.0-1.0-0.9-1.0-1.0-1.1-0.9-1.0
Social time3.84.95.62.22.22.22.22.22.42.22.22.22.22.22.12.22.2
Conditioned locomotion0.00.10.10.30.20.20.20.20.30.20.20.20.20.20.20.20.3
Cocaine response after cond. corrected0.70.81.3-0.9-0.9-0.9-0.8-0.9-0.8-0.9-0.9-0.8-0.9-0.9-1.1-0.9-0.9
Cocaine response after cond. not corrected1.82.02.7-1.4-1.5-1.4-1.3-1.4-1.4-1.4-1.4-1.3-1.4-1.4-1.6-1.3-1.3
Cocaine response before conditioning1.61.92.1-1.4-1.4-1.4-1.4-1.4-1.5-1.4-1.4-1.4-1.4-1.4-1.3-1.4-1.4
Saline control response1.72.22.7-1.5-1.4-1.5-1.5-1.5-1.6-1.5-1.5-1.5-1.5-1.5-1.4-1.5-1.5
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.4-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.5-0.2-0.3
Condit. Reinf. active-inactive response ratio0.60.71.1-0.8-1.0-0.8-0.7-0.8-1.0-0.8-0.8-0.8-0.8-0.7-1.0-0.7-0.8
Condit. Reinf. active responses0.10.10.20.40.30.30.30.30.40.30.30.30.30.30.30.40.3
Condit. Reinf. inactive responses0.91.11.51.11.11.01.01.01.21.01.01.01.01.01.11.01.0
Condit. Reinf. lever presses0.30.40.6-0.6-0.6-0.7-0.6-0.7-0.8-0.7-0.7-0.7-0.7-0.6-0.7-0.5-0.6
Condit. Reinf. lever reinforcers received0.10.10.20.40.40.30.40.30.40.40.40.30.30.40.30.40.4
Pavlov. Cond. lever latency0.00.00.0-0.1-0.10.00.00.0-0.10.00.00.00.00.0-0.10.0-0.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.1-0.4-0.3-0.1-0.3-0.3-0.2-0.3-0.1-0.3-0.1-0.60.0-0.1
Pavlov. Cond. change in total contacts0.20.20.30.50.40.40.50.40.50.50.40.50.40.50.30.60.5
Pavlov. Cond. index score0.00.00.00.10.00.00.10.00.10.10.00.10.00.1-0.20.20.2
Pavlov. Cond. latency score0.00.00.10.20.10.10.30.20.20.20.20.20.10.2-0.00.30.3
Pavlov. Cond. lever contacts0.20.20.3-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.4
Pavlov. Cond. magazine entry number0.40.50.7-0.8-0.6-0.6-0.7-0.6-0.7-0.7-0.6-0.7-0.6-0.7-0.3-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.10.0-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.0-0.2-0.2-0.0-0.1-0.2-0.1-0.1-0.1-0.2-0.1-0.30.00.0
Pavlov. Cond. response bias0.00.00.1-0.1-0.2-0.2-0.1-0.2-0.1-0.2-0.2-0.1-0.2-0.1-0.4-0.1-0.1
Conditioned reinforcement - actives0.90.91.0-0.9-1.0-1.0-0.9-1.0-0.8-1.0-1.0-1.0-1.0-0.9-1.0-0.9-0.9
Conditioned reinforcement - inactives0.70.70.8-0.9-0.8-0.9-0.9-0.9-0.7-0.9-0.9-0.9-0.9-0.9-0.8-0.9-0.9
Conditioned locomotion3.03.63.7-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.8-1.9
Intermittent access intake day 1-15 change0.30.30.6-0.4-0.5-0.5-0.5-0.5-0.8-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4
Intermittent access intake escalation0.30.30.8-0.4-0.4-0.5-0.5-0.5-0.9-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.4
Intermittent access intake escalation 20.40.41.4-0.6-0.6-0.6-0.6-0.6-1.2-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.5
Intermitt. access day 1 inactive lever presses0.20.20.3-0.4-0.4-0.5-0.5-0.50.2-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.4
Intermitt. access day 15 inactive lever presses0.30.40.4-0.6-0.6-0.6-0.6-0.60.0-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6
Intermitt. access escalation Index0.20.20.20.40.40.50.50.50.40.50.50.50.50.50.40.50.4
Intermittent access day 1 total infusions0.91.01.1-1.0-1.0-1.0-1.0-1.0-0.7-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0
Intermittent access day 15 total infusions0.60.70.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.8-0.8-0.8-0.8-0.8
Intermittent access terminal intake (last 3 days)1.01.11.2-1.0-1.1-1.1-1.1-1.1-0.9-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.0
Intermittent access total infusions2.02.22.3-1.5-1.5-1.5-1.5-1.5-1.2-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5
Intermittent access day 1 locomotion0.20.20.2-0.5-0.5-0.5-0.5-0.5-0.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4
Intermittent access day 15 total locomotion0.50.50.7-0.7-0.7-0.7-0.7-0.7-0.9-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7
Intermittent access total locomotion1.92.12.2-1.4-1.5-1.5-1.5-1.5-1.3-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.4
Intermittent access standard deviation0.50.50.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.7
Cocaine induced anxiety1.21.42.81.11.11.11.11.11.71.11.11.11.11.11.11.11.0
Post-drug Anxiety0.20.20.80.30.50.40.40.40.90.40.40.40.40.40.50.30.3
Baseline Anxiety0.60.60.8-0.8-0.7-0.8-0.8-0.8-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.8
Lifetime Intake1.61.81.9-1.3-1.3-1.4-1.4-1.3-1.0-1.4-1.4-1.4-1.4-1.4-1.3-1.4-1.3
Incentive Sensitization - Responses0.10.10.2-0.3-0.2-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.2-0.4-0.4
Incentive Sensitization - Breakpoint0.10.10.1-0.3-0.2-0.3-0.3-0.3-0.1-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3
Progressive ratio test 1 active lever presses0.91.01.0-1.0-1.0-1.0-1.0-1.0-0.8-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0
Progressive ratio test 1 breakpoint0.60.60.7-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8
Progressive ratio test 1 inactive lever presses0.50.60.7-0.7-0.8-0.8-0.8-0.8-0.4-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.7
Progressive ratio test 2 active lever presses0.30.30.4-0.5-0.4-0.5-0.6-0.5-0.3-0.5-0.5-0.5-0.5-0.6-0.4-0.6-0.6
Progressive ratio test 2 breakpoint0.20.20.3-0.5-0.4-0.4-0.5-0.4-0.1-0.5-0.4-0.5-0.4-0.5-0.4-0.5-0.5
Progressive ratio test 2 inactive lever presses0.00.00.20.10.10.10.00.10.40.10.10.00.10.00.1-0.00.0
Total sessions with >9 infusions3.03.33.5-1.9-1.8-1.8-1.9-1.8-1.5-1.8-1.8-1.9-1.8-1.8-1.8-1.8-1.9
Short access day 1 total inactive lever presses1.41.61.8-1.3-1.2-1.3-1.3-1.3-1.1-1.3-1.3-1.3-1.3-1.3-1.2-1.3-1.3
Short access day 10 total inactive lever presses0.60.60.70.80.80.80.80.80.80.80.80.80.80.80.80.70.8
Short access day 1 total infusions0.91.01.2-1.0-1.0-1.0-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0
Short access day 10 total infusions2.32.62.7-1.6-1.6-1.6-1.6-1.6-1.1-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6
Short access total infusions0.40.50.6-0.7-0.7-0.7-0.7-0.7-0.4-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8
Short access day 1 locomotion1.01.11.3-1.1-1.0-1.0-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.1
Short access day 10 total locomotion0.00.00.20.0-0.00.00.00.0-0.40.00.00.00.00.0-0.00.10.1
Short access total locomotion0.10.10.1-0.3-0.4-0.3-0.3-0.3-0.2-0.3-0.3-0.4-0.4-0.3-0.4-0.3-0.3
Compulsive drug intake0.00.00.3-0.0-0.2-0.1-0.1-0.10.5-0.1-0.1-0.1-0.1-0.1-0.20.00.0
One hour access (0.3 mA shock)0.00.00.10.20.20.20.20.20.10.20.20.20.20.20.20.20.2
One hour access (shock baseline)1.31.52.2-1.2-1.2-1.2-1.2-1.2-1.5-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.2
Number of responses in last shaping day3.23.34.9-1.8-1.7-1.8-1.8-1.8-2.2-1.8-1.8-1.8-1.8-1.8-1.7-1.8-1.8
Context. condit. distance diff. score0.10.20.2-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5
Locomotion velocity, session 10.00.00.10.20.30.20.10.20.40.10.20.10.20.10.30.10.1
Locomotion distance, session 10.00.10.2-0.2-0.4-0.2-0.2-0.2-0.4-0.2-0.2-0.2-0.2-0.2-0.3-0.1-0.1
Locomotion velocity, session 21.21.41.8-1.2-1.0-1.2-1.3-1.2-1.0-1.2-1.2-1.3-1.2-1.3-1.0-1.4-1.3
Locomotion distance, session 20.30.40.7-0.6-0.8-0.7-0.6-0.7-0.8-0.7-0.7-0.6-0.7-0.6-0.8-0.5-0.6
Locomotion velocity, session 30.20.30.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Locomotion distance, session 30.80.91.00.90.81.01.01.01.01.01.01.01.01.00.81.01.0
Stereotopy head waving bouts, day 30.91.01.4-1.1-0.8-1.0-1.1-1.0-0.9-1.0-1.0-1.1-1.0-1.1-0.7-1.2-1.1
Stereotopy head waving duration, day 30.91.01.2-1.1-0.9-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.1-0.9-1.1-1.1
Locomotion velocity, session 70.10.20.30.40.20.40.50.40.30.40.40.40.40.50.20.50.5
Locomotion distance, session 70.00.00.1-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.0
Stereotopy head waving bouts, day 70.70.80.9-0.9-0.8-0.8-0.9-0.8-0.9-0.9-0.8-0.9-0.8-0.9-0.7-0.9-1.0
Stereotopy head waving duration, day 70.60.81.0-0.9-0.8-0.9-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.7-0.9-1.0
Locomotion velocity, session 80.00.00.10.00.10.10.00.10.20.10.10.00.10.00.20.0-0.0
Locomotion distance, session 80.00.10.2-0.3-0.4-0.2-0.1-0.2-0.4-0.2-0.2-0.1-0.2-0.1-0.4-0.0-0.2
Degree of sensitization distance0.60.60.6-0.7-0.7-0.8-0.7-0.8-0.8-0.8-0.8-0.7-0.8-0.7-0.7-0.8-0.7
Degree of sensitization stereotypy1.01.11.2-1.1-1.0-1.0-1.1-1.0-1.1-1.0-1.0-1.1-1.0-1.1-0.9-1.1-1.1
Condit. Reinf. active minus inactive responses0.40.40.6-0.6-0.7-0.7-0.6-0.7-0.7-0.7-0.7-0.6-0.7-0.6-0.8-0.5-0.6
Condit. Reinf. active-inactive response ratio0.30.40.6-0.6-0.7-0.6-0.5-0.6-0.8-0.6-0.6-0.5-0.6-0.5-0.8-0.4-0.5
Condit. Reinf. active responses0.30.30.5-0.5-0.7-0.6-0.5-0.6-0.7-0.5-0.6-0.5-0.6-0.5-0.7-0.3-0.5
Condit. Reinf. inactive responses0.00.00.10.1-0.20.00.20.0-0.20.10.00.10.00.1-0.20.30.2
Incentive salience index mean0.20.30.3-0.5-0.6-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.6-0.4-0.5
Condit. Reinf. lever presses0.00.00.00.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.0-0.0-0.00.00.00.0
Time in familiar zone, hab. session 10.20.20.2-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.4
Time in novel zone, hab. session 10.50.50.6-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7
Total zone transitions, hab. session 10.20.30.5-0.5-0.7-0.5-0.4-0.5-0.7-0.5-0.5-0.5-0.5-0.5-0.6-0.4-0.5
Total locomotion distance, hab. session 10.40.60.70.80.80.80.80.80.70.80.80.80.80.80.80.80.7
Locomotion velocity, hab. session 11.21.81.91.31.31.31.31.31.31.31.31.31.31.31.41.41.3
Time in familiar zone, hab. session 20.20.20.3-0.5-0.3-0.4-0.5-0.4-0.3-0.4-0.4-0.5-0.4-0.5-0.1-0.6-0.5
Time in novel zone, hab. session 20.00.00.10.20.10.10.20.10.10.10.10.20.10.2-0.10.20.2
Total zone transitions, hab. session 20.50.60.8-0.8-0.7-0.8-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.6-0.9-0.8
Total locomotion distance, hab. session 20.60.81.10.91.00.90.90.91.10.90.90.90.90.91.00.90.9
Locomotion velocity, hab. session 20.40.50.70.70.80.70.70.70.80.70.70.70.70.70.80.70.7
Novel to familiar place preference ratio1.01.12.1-1.0-1.3-1.0-0.8-1.0-1.5-1.0-1.0-0.9-1.0-0.8-1.4-0.7-0.8
Novelty place preference0.91.01.8-0.9-1.2-1.0-0.8-0.9-1.4-0.9-1.0-0.8-1.0-0.8-1.3-0.7-0.8
Time in novel zone, NPP test1.11.12.1-1.0-1.3-1.1-0.9-1.0-1.4-1.0-1.1-0.9-1.1-0.9-1.4-0.8-0.9
Total zone transitions, NPP test0.10.20.3-0.4-0.4-0.5-0.5-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.3-0.5-0.4
Total locomotion distance, NPP test0.10.10.1-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.4
Locomotion velocity, NPP test0.10.10.1-0.3-0.4-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3
Pavlov. Cond. lever latency0.30.40.50.60.60.70.60.70.60.60.70.60.70.60.70.60.6
Pavlov. Cond. magazine entry latency0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.4-0.2-0.3
Pavlov. Cond. change in total contacts0.70.71.00.90.80.80.90.80.80.80.80.90.80.90.71.00.9
Pavlov. Cond. index score0.20.30.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.5
Pavlov. Cond. latency score0.00.00.0-0.2-0.1-0.2-0.2-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2
Pavlov. Cond. lever contacts0.50.60.7-0.7-0.7-0.8-0.7-0.8-0.8-0.8-0.8-0.7-0.8-0.7-0.8-0.7-0.7
Pavlov. Cond. magazine entry number0.00.00.00.10.00.10.00.10.00.00.10.00.10.00.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.6-0.6-0.7-0.6-0.7-0.7-0.6-0.6-0.6-0.7-0.6-0.7-0.6-0.6
Pavlov. Cond. response bias1.21.51.8-1.2-1.2-1.2-1.2-1.2-1.3-1.2-1.2-1.2-1.2-1.2-1.3-1.0-1.2
Bone: apparent density0.00.10.20.2-0.00.20.40.20.00.30.20.30.20.3-0.00.50.3
Bone surface0.10.10.3-0.3-0.5-0.4-0.3-0.4-0.5-0.4-0.4-0.3-0.4-0.3-0.6-0.2-0.2
Bone volume0.00.10.2-0.2-0.4-0.3-0.1-0.2-0.5-0.2-0.3-0.2-0.3-0.2-0.5-0.1-0.2
Bone: connectivity density0.10.10.30.30.10.30.50.30.10.30.30.40.30.40.10.60.4
Bone: cortical apparent density0.00.00.10.10.10.20.20.20.10.20.20.10.20.20.30.30.1
Bone: cortical area1.11.62.0-1.2-1.2-1.3-1.3-1.3-1.4-1.3-1.3-1.3-1.3-1.3-1.2-1.3-1.2
Bone: cortical porosity0.10.10.30.30.40.40.30.40.60.40.40.30.40.30.50.20.2
Bone: cortical porosity0.00.00.0-0.1-0.00.1-0.00.10.10.00.1-0.00.1-0.00.1-0.1-0.1
Bone: cortical thickness0.30.50.6-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.7-0.6-0.7-0.6
Bone: cortical thickness1.21.51.9-1.2-1.2-1.2-1.2-1.2-1.4-1.2-1.2-1.2-1.2-1.2-1.2-1.1-1.2
Bone: cortical tissue density0.00.10.10.20.20.20.30.30.20.20.20.20.20.20.30.30.1
Bone: elastic displacement1.41.61.91.11.21.31.31.31.41.31.31.31.31.31.21.21.2
Bone: elastic work0.00.00.0-0.1-0.2-0.0-0.0-0.0-0.1-0.0-0.1-0.0-0.0-0.0-0.0-0.1-0.0
Bone: endosteal estimation0.00.10.10.30.30.20.30.20.20.20.20.20.20.20.20.20.3
Bone: endosteal perimeter0.00.00.00.00.0-0.0-0.0-0.00.0-0.0-0.0-0.0-0.0-0.00.0-0.00.0
Bone: final force0.30.40.6-0.6-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.7-0.6-0.6-0.6
Bone: final moment0.40.70.9-0.8-0.8-0.9-0.9-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.9-0.8
Bone: marrow area0.00.00.10.30.20.20.20.20.10.20.20.20.20.20.10.20.3
Bone: maximum diameter1.83.43.6-1.7-1.6-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.8-1.9-1.8
Bone: maximum force0.20.30.4-0.5-0.6-0.5-0.5-0.5-0.7-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Bone: maximum moment0.20.40.6-0.6-0.7-0.7-0.7-0.6-0.8-0.7-0.7-0.7-0.7-0.7-0.6-0.7-0.6
Bone: minimum diameter0.20.30.4-0.5-0.6-0.5-0.5-0.5-0.7-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Bone: periosteal estimation0.10.30.4-0.4-0.4-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.4
Bone: periosteal perimeter0.10.20.2-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.4
Bone: post-yield work0.40.60.80.70.60.70.80.80.60.80.70.80.70.80.70.90.8
Bone: stiffness0.81.21.4-1.1-1.1-1.1-1.1-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.0-1.1-1.1
Bone: tissue strength0.40.40.50.60.50.60.70.60.70.60.60.70.60.70.40.70.7
Bone: trabecular number0.20.30.60.50.30.60.70.60.40.60.60.60.60.70.30.80.6
Bone: trabecular spacing0.20.30.5-0.5-0.2-0.5-0.6-0.6-0.3-0.5-0.5-0.5-0.5-0.6-0.6-0.7-0.5
Bone: trabecular thickness1.01.21.8-1.1-1.2-1.1-1.0-1.1-1.3-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.0
Bone: trabecular tissue density0.60.91.0-0.9-0.8-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.9-0.9-0.9
Breakpoint value in progressive ratio session5.86.47.72.52.62.52.52.52.82.52.52.52.52.52.52.52.5
Distance traveled before self-admin0.30.30.4-0.5-0.6-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.6-0.6-0.5
Distance traveled after self-admin0.60.70.70.90.80.80.80.80.80.80.80.80.80.80.80.80.8
Delta time in closed arm before/after self-admin0.00.00.0-0.0-0.1-0.00.0-0.0-0.1-0.0-0.0-0.0-0.00.0-0.10.10.0
Delta time in open arm before/after self-admin0.20.10.20.40.40.40.40.40.40.40.40.40.40.40.40.30.4
Diff in mean of infusions in LGA sessions4.14.65.52.12.12.12.12.12.32.12.12.12.12.12.12.12.1
Extinction: sum of active levers before priming1.92.02.41.41.41.41.41.41.61.41.41.41.41.41.41.41.3
Active lever presses in extinction session 60.00.00.0-0.1-0.0-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.1
Delta distance traveled before/after self-admin3.43.74.21.91.91.91.91.92.11.91.91.91.91.91.91.91.9
Delta ambulatory time before/after self-admin1.21.31.51.11.11.11.11.11.21.11.11.11.11.11.11.11.1
Time in closed arm before self-admin1.61.82.3-1.3-1.4-1.3-1.3-1.3-1.5-1.3-1.3-1.3-1.3-1.3-1.3-1.4-1.2
Time in closed arm after self-admin0.00.00.0-0.0-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.0-0.0
Time in open arm before self-admin0.90.91.30.91.01.00.91.01.11.01.01.01.01.01.01.00.8
Time in open arm after self-admin0.80.91.21.01.00.90.90.91.10.90.90.91.00.91.00.90.9
Sum of active levers in priming session hrs 5-61.31.31.61.11.21.11.11.11.31.11.11.11.11.11.11.11.1
Time to tail flick, vehicle, before self-admin3.43.53.9-1.9-1.8-1.8-1.9-1.8-2.0-1.9-1.8-1.9-1.8-1.9-1.8-1.8-1.9
Time to tail flick, vehicle, after self-admin0.30.30.3-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.6-0.5
Time to tail flick, test, before self-admin0.30.30.50.50.60.60.60.60.70.60.60.60.60.60.60.60.5
Time to tail flick, test, after self-admin0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA0.00.00.10.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Delta time to tail flick, test, before/after SA2.32.02.6-1.3-1.4-1.4-1.4-1.4-1.6-1.4-1.4-1.4-1.4-1.4-1.5-1.5-1.3
Ambulatory time before self-admin0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Ambulatory time after self-admin1.01.11.11.01.01.01.01.01.11.01.01.01.01.01.01.01.0
Total heroin consumption0.50.60.70.80.80.80.80.80.90.80.80.80.80.80.80.70.8
Area under the delay curve2.22.43.11.61.71.51.41.51.61.51.51.41.51.51.71.31.5
Delay disc. indifference point, 0s delay1.21.31.81.11.21.11.11.11.21.11.11.11.11.11.41.11.1
Delay disc. indifference point, 16s delay1.31.31.51.21.21.11.11.11.21.11.11.11.11.11.21.11.1
Delay disc. indifference point, 2s delay4.04.55.92.12.42.12.02.12.32.12.12.02.12.02.41.82.0
Delay disc. indifference point, 24s delay0.10.10.2-0.2-0.3-0.3-0.2-0.3-0.5-0.3-0.3-0.3-0.3-0.2-0.4-0.2-0.2
Delay disc. indifference point, 4s delay0.00.00.00.00.10.0-0.10.00.0-0.00.0-0.10.0-0.00.2-0.2-0.0
Delay disc. indifference point, 8s delay1.92.02.41.51.51.41.41.41.51.41.41.41.41.41.51.31.4
Delay discount exponential model param1.61.72.3-1.4-1.5-1.3-1.2-1.3-1.4-1.3-1.3-1.2-1.3-1.3-1.5-1.1-1.3
Delay discount hyperbolic model param1.31.42.0-1.2-1.4-1.2-1.1-1.2-1.2-1.2-1.2-1.1-1.2-1.1-1.4-1.0-1.2
Fecal boli incidents, locomotor time 10.00.00.0-0.00.1-0.0-0.0-0.00.0-0.0-0.0-0.0-0.0-0.00.1-0.0-0.0
Change in fecal boli incidents, locomotor task1.00.91.11.01.01.00.91.01.01.01.00.91.00.91.00.90.9
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.10.10.20.1-0.00.10.10.20.10.2-0.10.30.2
Bouts of movement, locomotor time 12.42.62.91.61.51.61.71.61.61.61.61.61.61.71.51.71.6
Total resting periods, locomotor time 12.93.23.41.81.71.81.81.81.81.81.81.81.81.81.71.81.8
Rest time, locomotor task time 10.00.00.10.20.10.20.20.20.20.20.20.20.20.20.10.30.2
Distance moved, locomotor task time 10.10.10.3-0.4-0.2-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.2-0.5-0.4
Vertical activity count, locomotor time 10.10.10.20.40.50.40.30.40.40.40.40.30.40.30.50.30.4
Time >=10cm from walls, locomotor time 20.20.20.30.40.50.40.40.40.60.40.40.40.40.40.50.30.4
Bouts of movement, locomotor time 25.66.06.52.42.32.42.52.42.62.52.42.52.42.52.32.52.5
Total resting periods, locomotor time 24.95.25.72.32.12.32.42.32.42.32.32.32.32.32.12.42.3
Rest time, locomotor task time 20.00.00.10.1-0.10.10.20.1-0.10.10.10.10.10.1-0.10.30.1
Distance moved, locomotor task time 20.40.50.7-0.6-0.5-0.7-0.7-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.9-0.7
Vertical activity count, locomotor time 20.30.30.50.60.70.50.50.50.60.50.50.50.50.50.70.40.5
Weight adjusted by age0.00.00.10.20.30.20.10.20.30.10.20.10.20.10.20.10.2
Seeking ratio, delayed vs. immediate footshock1.61.82.01.31.31.41.41.41.41.41.41.41.41.41.31.41.3
Locomotion in novel chamber0.40.50.70.70.70.70.70.70.80.70.70.70.70.70.60.60.8
Locomotion in novel chamber post-restriction1.41.62.01.21.21.31.31.31.41.31.31.31.31.31.31.31.2
Progressive ratio0.60.71.20.80.80.90.80.81.10.90.90.90.90.80.80.90.8
Food seeking constrained by brief footshock5.66.87.02.62.52.62.62.62.72.62.62.62.62.62.62.62.6
Seeking ratio, punishment vs. effort0.81.01.21.11.01.01.11.00.81.01.01.01.01.01.11.01.1
Run reversals in cocaine runway, females0.40.40.40.60.60.60.60.60.70.60.60.60.60.60.60.60.6
Run reversals in cocaine runway, males0.80.80.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9
Latency to leave start box in cocaine runway0.00.10.2-0.2-0.4-0.2-0.1-0.2-0.4-0.2-0.2-0.2-0.2-0.1-0.4-0.1-0.1
Latency to leave start box in cocaine runway, F0.50.60.7-0.7-0.8-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.7
Latency to leave start box in cocaine runway, M0.00.00.1-0.1-0.3-0.10.0-0.1-0.4-0.1-0.1-0.0-0.1-0.0-0.30.1-0.0
Cd content in liver0.00.00.10.00.0-0.00.0-0.00.10.00.00.10.00.0-0.20.00.0
Co content in liver2.22.63.71.61.61.61.61.61.91.61.61.61.61.61.41.61.6
Cu content in liver0.10.10.2-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.4-0.3
Fe content in liver1.11.21.5-1.0-0.7-1.1-1.2-1.1-1.2-1.2-1.1-1.2-1.2-1.2-0.8-1.2-1.2
K content in liver0.10.10.3-0.30.0-0.3-0.4-0.4-0.2-0.4-0.3-0.4-0.3-0.4-0.2-0.5-0.4
Mg content in liver0.10.10.2-0.20.1-0.3-0.4-0.3-0.1-0.3-0.3-0.3-0.3-0.3-0.1-0.4-0.3
Mn content in liver0.91.11.2-1.0-1.0-1.0-1.1-1.1-1.0-1.1-1.1-1.0-1.0-1.1-1.1-1.1-1.0
Na content in liver0.10.10.20.20.30.30.20.30.40.30.30.30.30.20.40.10.2
Rb content in liver0.00.00.10.10.3-0.10.0-0.1-0.1-0.0-0.10.0-0.00.0-0.10.00.1
Se content in liver1.41.62.1-1.3-1.1-1.2-1.4-1.2-1.2-1.3-1.2-1.4-1.2-1.4-1.0-1.5-1.4
Sr content in liver0.20.20.3-0.5-0.4-0.3-0.5-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.2-0.5-0.5
Zn content in liver0.10.10.3-0.3-0.4-0.3-0.2-0.3-0.1-0.3-0.3-0.2-0.3-0.3-0.5-0.3-0.3