| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000017550 | 0.382 | 0.184 | 1.3e-14 | 0.149 | 0.152 | 0.149 | 0.164 | 2.4e-08 | 1.6e-08 | 2.3e-08 | 4.3e-09 |
| 2 | Brain | gene expression | ENSRNOG00000017550 | 0.400 | 0.160 | 0.0e+00 | 0.284 | 0.302 | 0.301 | 0.310 | 1.8e-26 | 2.1e-28 | 2.7e-28 | 3.4e-29 |
| 3 | Eye | intron excision ratio | chr3:116141232:116144493 | 0.605 | 0.219 | 2.4e-03 | 0.100 | -0.008 | -0.001 | 0.049 | 1.3e-02 | 4.5e-01 | 3.3e-01 | 6.3e-02 |
| 4 | IL | gene expression | ENSRNOG00000017550 | 0.408 | 0.173 | 6.0e-06 | 0.162 | 0.185 | 0.163 | 0.201 | 1.1e-04 | 3.2e-05 | 9.9e-05 | 1.4e-05 |
| 5 | LHb | gene expression | ENSRNOG00000017550 | 0.434 | 0.177 | 3.3e-06 | 0.099 | 0.068 | 0.129 | 0.098 | 2.4e-03 | 1.1e-02 | 5.8e-04 | 2.6e-03 |
| 6 | Liver | gene expression | ENSRNOG00000017550 | 0.090 | 0.062 | 2.6e-07 | 0.034 | 0.035 | 0.037 | 0.034 | 1.1e-04 | 7.7e-05 | 4.8e-05 | 9.6e-05 |
| 7 | NAcc | gene expression | ENSRNOG00000017550 | 0.240 | 0.110 | 0.0e+00 | 0.227 | 0.226 | 0.230 | 0.230 | 7.1e-17 | 9.3e-17 | 4.4e-17 | 4.6e-17 |
| 8 | PL | gene expression | ENSRNOG00000017550 | 0.222 | 0.111 | 2.3e-14 | 0.169 | 0.171 | 0.167 | 0.168 | 7.5e-13 | 5.7e-13 | 1.1e-12 | 8.7e-13 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Locomotion distance, session 8 | 6.8 | 10.1 | 15.5 | -3.4 | -3.5 | 3.9 | -2.8 | -3.5 | -0.5 | -3.7 | -2.8 |
| Heart weight | 6.1 | 8.7 | 11.3 | -3.3 | -3.3 | 3.2 | -2.8 | -3.2 | -0.3 | -3.4 | -2.7 |
| Distance traveled before self-admin | 5.7 | 6.2 | 8.0 | -2.7 | -2.7 | 2.8 | -2.5 | -2.7 | -0.1 | -2.8 | -2.4 |
| Delay discounting water rate 0 sec | 5.5 | 8.7 | 11.8 | -3.2 | -3.3 | 3.4 | -2.8 | -3.2 | -0.7 | -3.3 | -2.7 |
| Bouts of movement, locomotor time 1 | 5.4 | 6.0 | 11.8 | 2.6 | 2.5 | -3.4 | 2.3 | 2.1 | -0.5 | 2.7 | 2.4 |
| Weight adjusted by age | 5.4 | 6.1 | 8.0 | -2.7 | -2.7 | 2.7 | -2.3 | -2.8 | -0.3 | -2.8 | -2.3 |
| Total resting periods, locomotor time 1 | 5.3 | 5.9 | 13.5 | 2.6 | 2.5 | -3.7 | 2.1 | 1.9 | -0.2 | 2.7 | 2.3 |
| Locomotion distance, session 3 | 5.2 | 5.6 | 9.0 | -2.2 | -2.2 | 2.2 | -3.0 | -2.0 | 2.5 | -1.5 | -3.0 |
| Seeking ratio, punishment vs. effort | 5.2 | 6.4 | 11.9 | -2.9 | -2.8 | 1.5 | -2.7 | -3.4 | 0.1 | -2.7 | -2.5 |
| Delay disc. indifference point, 0s delay | 5.1 | 5.5 | 8.3 | 2.6 | 2.6 | -2.9 | 2.3 | 2.1 | -0.3 | 2.6 | 2.4 |
| Progressive ratio | 5.1 | 5.9 | 11.3 | 2.7 | 2.6 | -1.0 | 2.8 | 3.4 | -1.0 | 2.2 | 2.7 |
| Cocaine induced anxiety | 5.0 | 5.8 | 13.1 | 2.1 | 2.0 | 0.4 | 2.8 | 2.8 | -3.6 | 1.0 | 2.9 |
| Body weight | 4.6 | 19.5 | 27.0 | -4.7 | -4.5 | 4.1 | -5.1 | -4.6 | 2.3 | -4.0 | -5.2 |
| Locomotion distance, session 7 | 4.6 | 5.9 | 8.7 | -2.7 | -2.7 | 2.9 | -2.0 | -2.7 | -0.5 | -2.9 | -2.2 |
| Condit. Reinf. active-inactive response ratio | 3.9 | 4.1 | 4.9 | -2.2 | -2.2 | 2.2 | -2.1 | -2.2 | 0.3 | -2.1 | -2.1 |
| Ambulatory time before self-admin | 3.9 | 4.1 | 4.9 | -2.2 | -2.1 | 2.1 | -2.2 | -2.2 | 0.5 | -2.1 | -2.2 |
| Delay discounting time to switch 0 sec | 3.8 | 5.9 | 7.9 | 2.7 | 2.7 | -2.8 | 2.2 | 2.6 | 0.9 | 2.8 | 2.1 |
| Condit. Reinf. active responses | 3.8 | 5.3 | 7.0 | -2.4 | -2.5 | 2.5 | -2.7 | -2.5 | 0.7 | -2.3 | -2.4 |
| Conditioned reinforcement - inactives | 3.8 | 4.3 | 6.7 | -2.3 | -2.4 | 2.1 | -1.7 | -2.5 | -1.1 | -2.6 | -1.5 |
| Bone: maximum diameter | 3.8 | 6.9 | 8.3 | -2.8 | -2.8 | 2.9 | -2.9 | -2.9 | 0.5 | -2.6 | -2.8 |
| Saline control response | 3.7 | 4.9 | 6.6 | -2.3 | -2.3 | 2.2 | -2.6 | -2.4 | 1.2 | -2.0 | -2.5 |
| Tail length | 3.6 | 10.8 | 16.8 | -3.4 | -3.2 | 3.0 | -3.8 | -3.4 | 2.3 | -2.7 | -4.1 |
| Length with tail | 3.5 | 12.7 | 15.5 | -3.7 | -3.7 | 3.8 | -3.9 | -3.9 | 0.8 | -3.6 | -3.9 |
| Condit. Reinf. active minus inactive responses | 3.4 | 4.2 | 5.6 | -2.2 | -2.2 | 2.4 | -2.2 | -2.2 | 0.1 | -2.2 | -2.0 |
| Condit. Reinf. lever reinforcers received | 3.3 | 4.7 | 6.0 | -2.2 | -2.3 | 2.4 | -2.4 | -2.3 | 0.4 | -2.2 | -2.2 |
| Pavlov. Cond. response bias | 3.0 | 4.1 | 5.5 | -2.1 | -2.1 | 2.1 | -2.3 | -2.2 | 1.0 | -1.8 | -2.3 |
| Bone: final force | 3.0 | 5.0 | 6.0 | -2.4 | -2.4 | 2.3 | -2.4 | -2.3 | 0.9 | -2.2 | -2.4 |
| Distance traveled after self-admin | 3.0 | 3.3 | 4.0 | -1.9 | -1.9 | 1.9 | -1.9 | -2.0 | 0.7 | -1.9 | -2.0 |
| Delta ambulatory time before/after self-admin | 3.0 | 3.2 | 4.4 | 2.0 | 1.9 | -2.1 | 1.8 | 1.9 | 0.6 | 2.0 | 1.6 |
| Latency to leave start box in cocaine runway, F | 3.0 | 3.4 | 4.9 | 2.2 | 2.1 | -1.4 | 1.7 | 2.2 | 0.1 | 2.2 | 1.8 |
| Rb content in liver | 3.0 | 3.8 | 8.1 | -2.0 | -2.0 | 2.8 | -2.2 | -1.3 | 0.8 | -1.9 | -1.9 |
| BMI without tail | 2.9 | 6.1 | 9.9 | -2.7 | -2.4 | 2.1 | -2.9 | -2.5 | 1.9 | -2.0 | -3.2 |
| Bone: trabecular number | 2.9 | 4.6 | 5.7 | -2.3 | -2.4 | 2.4 | -2.2 | -2.3 | -0.3 | -2.2 | -2.2 |
| Pavlov. Cond. lever latency | 2.8 | 3.9 | 5.1 | 2.1 | 2.1 | -2.0 | 2.3 | 2.1 | -0.9 | 1.8 | 2.2 |
| Total locomotion distance, NPP test | 2.8 | 3.9 | 6.1 | -2.0 | -2.2 | 2.5 | -1.3 | -2.1 | -1.5 | -2.5 | -1.2 |
| Reaction time num false alarms | 2.7 | 3.8 | 5.3 | -2.1 | -2.1 | 2.3 | -1.9 | -2.1 | -0.1 | -2.2 | -1.8 |
| Pavlov. Cond. lever contacts | 2.7 | 3.8 | 5.1 | -2.0 | -2.0 | 2.0 | -2.3 | -2.1 | 0.9 | -1.7 | -2.2 |
| Intermittent access intake day 1-15 change | 2.6 | 2.6 | 4.0 | -2.0 | -1.9 | 1.0 | -1.7 | -1.9 | 0.4 | -1.7 | -1.7 |
| Total locomotion distance, hab. session 2 | 2.6 | 3.5 | 5.6 | -2.0 | -2.1 | 2.1 | -1.4 | -2.1 | -1.3 | -2.4 | -1.1 |
| Progressive ratio test 1 breakpoint | 2.5 | 2.6 | 3.3 | -1.8 | -1.7 | 1.5 | -1.8 | -1.5 | 1.2 | -1.5 | -1.8 |
| Locomotion distance, session 2 | 2.5 | 3.5 | 4.7 | -1.9 | -2.1 | 2.2 | -1.9 | -2.2 | -0.2 | -2.1 | -1.6 |
| Bone: cortical area | 2.4 | 3.6 | 4.9 | -2.1 | -2.0 | 2.0 | -2.2 | -2.0 | 0.8 | -1.7 | -2.1 |
| Bone: final moment | 2.4 | 4.0 | 4.8 | -2.2 | -2.1 | 2.1 | -2.1 | -2.1 | 0.9 | -1.9 | -2.2 |
| Bone: periosteal perimeter | 2.4 | 4.0 | 4.9 | -2.1 | -2.1 | 2.2 | -2.2 | -2.2 | 0.4 | -2.0 | -2.1 |
| Conditioned locomotion | 2.3 | 2.7 | 4.0 | -1.7 | -1.8 | 2.0 | -1.7 | -1.8 | -0.3 | -1.9 | -1.4 |
| Progressive ratio test 2 inactive lever presses | 2.3 | 2.7 | 4.3 | -1.8 | -1.9 | 1.8 | -1.3 | -1.8 | -0.7 | -2.1 | -1.2 |
| Context. condit. distance diff. score | 2.3 | 2.8 | 5.5 | -1.8 | -1.8 | 2.4 | -1.1 | -1.7 | -0.8 | -2.1 | -1.3 |
| Total zone transitions, hab. session 2 | 2.3 | 3.0 | 4.2 | -1.9 | -1.8 | 1.3 | -2.1 | -2.1 | 0.9 | -1.6 | -2.0 |
| Tibia length | 2.2 | 6.1 | 13.4 | -2.0 | -1.8 | 1.4 | -3.1 | -2.1 | 3.7 | -0.9 | -3.3 |
| Post-drug Anxiety | 2.2 | 2.4 | 4.7 | 1.4 | 1.3 | 0.1 | 1.7 | 2.0 | -2.2 | 0.7 | 1.9 |
| Progressive ratio test 1 active lever presses | 2.2 | 2.2 | 2.7 | -1.7 | -1.6 | 1.4 | -1.7 | -1.4 | 1.1 | -1.5 | -1.6 |
| Bone: apparent density | 2.2 | 3.7 | 4.7 | -2.1 | -2.2 | 2.2 | -1.9 | -2.1 | -0.3 | -2.0 | -1.9 |
| Bone: endosteal perimeter | 2.2 | 4.4 | 5.8 | -2.2 | -2.2 | 2.4 | -2.2 | -2.4 | 0.0 | -2.1 | -2.2 |
| Reaction time num false alarms AUC | 2.1 | 2.9 | 3.7 | -1.8 | -1.8 | 1.9 | -1.8 | -1.8 | 0.3 | -1.8 | -1.7 |
| Intermittent access intake escalation | 2.1 | 2.0 | 3.2 | -1.8 | -1.7 | 0.8 | -1.5 | -1.6 | 0.4 | -1.5 | -1.5 |
| Locomotion velocity, session 7 | 2.1 | 2.3 | 5.4 | -1.5 | -1.4 | 2.3 | -1.4 | -1.5 | 0.3 | -1.3 | -1.7 |
| Bone: cortical porosity | 2.1 | 2.2 | 4.0 | 1.5 | 1.6 | -1.7 | 0.7 | 1.5 | 1.8 | 2.0 | 0.6 |
| Bone: periosteal estimation | 2.1 | 4.4 | 5.6 | -2.2 | -2.1 | 2.4 | -2.2 | -2.3 | 0.4 | -1.9 | -2.4 |
| Se content in liver | 2.1 | 2.6 | 5.2 | -1.7 | -1.8 | 1.0 | -1.6 | -2.3 | -0.2 | -1.8 | -1.5 |
| Delay discounting water rate 6 sec | 2.0 | 2.8 | 3.4 | -1.8 | -1.8 | 1.8 | -1.8 | -1.8 | 0.1 | -1.7 | -1.8 |
| Locomotion velocity, hab. session 2 | 2.0 | 2.7 | 4.5 | -1.7 | -1.8 | 2.0 | -1.0 | -1.7 | -1.6 | -2.1 | -0.7 |
| Locomotion velocity, NPP test | 2.0 | 2.8 | 4.7 | -1.7 | -1.8 | 2.2 | -1.0 | -1.8 | -1.6 | -2.1 | -0.9 |
| Time in closed arm after self-admin | 2.0 | 2.1 | 3.2 | 1.8 | 1.6 | -1.5 | 1.4 | 1.4 | 0.7 | 1.8 | 1.1 |
| Pavlov. Cond. index score | 1.9 | 2.5 | 3.5 | -1.5 | -1.6 | 1.6 | -1.9 | -1.6 | 1.0 | -1.3 | -1.9 |
| Intermitt. access day 15 inactive lever presses | 1.8 | 1.9 | 3.4 | -1.3 | -1.4 | 1.5 | -0.6 | -1.6 | -1.8 | -1.8 | -0.5 |
| Social responses | 1.7 | 2.2 | 3.6 | -1.3 | -1.4 | 1.4 | -1.9 | -1.6 | 1.2 | -1.2 | -1.7 |
| Bone volume | 1.7 | 2.9 | 3.8 | -1.9 | -1.9 | 1.9 | -1.6 | -1.9 | -0.4 | -1.9 | -1.5 |
| Delta time in open arm before/after self-admin | 1.7 | 1.6 | 2.0 | -1.4 | -1.4 | 1.4 | -1.3 | -1.3 | -0.1 | -1.4 | -1.2 |
| Intermitt. access day 1 inactive lever presses | 1.6 | 1.7 | 2.8 | -1.4 | -1.5 | 1.2 | -1.2 | -1.7 | -0.5 | -1.5 | -1.1 |
| Intermittent access day 15 total locomotion | 1.6 | 1.7 | 3.1 | -1.5 | -1.6 | 1.5 | -1.0 | -1.3 | -0.7 | -1.8 | -0.8 |
| Stereotopy head waving bouts, day 3 | 1.6 | 2.0 | 5.8 | 0.8 | 0.7 | 1.5 | 1.4 | 1.5 | -2.4 | 0.2 | 1.6 |
| Total locomotion distance, hab. session 1 | 1.6 | 2.3 | 4.1 | -1.4 | -1.5 | 2.0 | -1.0 | -1.7 | -1.5 | -1.8 | -0.9 |
| Locomotion velocity, hab. session 1 | 1.6 | 2.3 | 3.6 | -1.4 | -1.5 | 1.9 | -1.0 | -1.8 | -1.5 | -1.8 | -1.0 |
| Run reversals in cocaine runway, males | 1.6 | 1.6 | 2.3 | -1.4 | -1.4 | 1.0 | -1.5 | -1.3 | 0.8 | -1.3 | -1.3 |
| Latency to leave start box in cocaine runway | 1.6 | 1.7 | 2.7 | 1.7 | 1.5 | -1.3 | 1.3 | 1.3 | -0.1 | 1.5 | 1.3 |
| Pavlov. Cond. change in total contacts | 1.5 | 2.1 | 3.3 | -1.4 | -1.4 | 1.3 | -1.8 | -1.5 | 1.0 | -1.1 | -1.8 |
| Progressive ratio test 1 inactive lever presses | 1.5 | 1.6 | 2.5 | -1.4 | -1.5 | 1.2 | -1.2 | -1.6 | -0.5 | -1.6 | -1.0 |
| Bone surface | 1.5 | 2.6 | 3.3 | -1.7 | -1.8 | 1.8 | -1.5 | -1.8 | -0.3 | -1.8 | -1.5 |
| Delay discounting water rate 12 sec | 1.4 | 2.1 | 3.4 | -1.5 | -1.6 | 1.8 | -1.1 | -1.6 | -1.0 | -1.6 | -1.2 |
| Pavlov. Cond. latency score | 1.4 | 1.8 | 2.4 | -1.3 | -1.4 | 1.5 | -1.5 | -1.5 | 0.6 | -1.1 | -1.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.4 | 1.9 | 2.8 | -1.3 | -1.3 | 1.3 | -1.7 | -1.4 | 1.0 | -1.1 | -1.6 |
| Bone: cortical porosity | 1.4 | 1.5 | 4.6 | 1.0 | 1.1 | -1.3 | 0.1 | 1.0 | 2.1 | 1.6 | 0.0 |
| Left kidney weight | 1.3 | 3.7 | 5.9 | -1.9 | -2.0 | 2.4 | -1.6 | -2.2 | -1.2 | -2.2 | -1.5 |
| Short access day 10 total inactive lever presses | 1.3 | 1.4 | 9.4 | 0.1 | -0.1 | 0.6 | 0.8 | -0.1 | -3.1 | -0.5 | 0.9 |
| Stereotopy head waving duration, day 3 | 1.3 | 1.6 | 3.1 | 1.2 | 1.1 | 0.5 | 1.4 | 1.8 | -1.3 | 0.8 | 1.6 |
| Time in open arm after self-admin | 1.3 | 1.4 | 2.2 | -1.3 | -1.3 | 1.4 | -0.9 | -1.2 | -1.0 | -1.5 | -0.7 |
| Total heroin consumption | 1.3 | 1.5 | 2.6 | -1.2 | -1.3 | 1.2 | -1.6 | -1.3 | 0.4 | -1.2 | -1.3 |
| Delay disc. indifference point, 24s delay | 1.3 | 1.3 | 2.5 | 1.1 | 1.2 | -1.6 | 1.2 | 0.8 | -0.7 | 1.0 | 1.2 |
| Sr content in liver | 1.3 | 1.2 | 3.9 | -1.0 | -0.9 | -0.6 | -1.0 | -2.0 | 0.3 | -0.8 | -1.2 |
| Tibialis anterior weight | 1.2 | 4.0 | 5.3 | -2.1 | -2.0 | 1.9 | -2.2 | -2.0 | 1.7 | -1.7 | -2.3 |
| Reaction time false alarm rate | 1.2 | 1.8 | 2.1 | -1.4 | -1.4 | 1.4 | -1.5 | -1.3 | 0.6 | -1.4 | -1.3 |
| Intermittent access total locomotion | 1.2 | 1.3 | 2.2 | -1.4 | -1.4 | 1.3 | -0.9 | -1.2 | -0.2 | -1.5 | -0.9 |
| Bone: connectivity density | 1.2 | 1.9 | 2.6 | -1.5 | -1.6 | 1.5 | -1.3 | -1.5 | -0.5 | -1.5 | -1.3 |
| Bone: stiffness | 1.2 | 1.9 | 2.7 | -1.5 | -1.5 | 1.6 | -1.4 | -1.5 | 0.3 | -1.5 | -1.3 |
| Bone: trabecular tissue density | 1.2 | 1.7 | 2.6 | -1.5 | -1.5 | 1.4 | -1.3 | -1.3 | 0.4 | -1.6 | -1.1 |
| Delta time to tail flick, vehicle, before/after SA | 1.2 | 1.2 | 2.5 | -1.0 | -0.9 | 0.8 | -1.3 | -1.0 | 1.6 | -0.6 | -1.3 |
| Ambulatory time after self-admin | 1.2 | 1.3 | 2.0 | -1.1 | -1.1 | 0.9 | -1.2 | -1.2 | 1.1 | -1.0 | -1.4 |
| Run reversals in cocaine runway, females | 1.2 | 1.2 | 2.3 | -1.2 | -1.2 | 1.0 | -1.0 | -1.5 | -0.3 | -1.2 | -1.1 |
| Condit. Reinf. lever presses | 1.1 | 1.5 | 2.3 | -1.2 | -1.2 | 1.2 | -1.5 | -1.3 | 0.9 | -1.0 | -1.5 |
| Baseline Anxiety | 1.1 | 1.1 | 2.7 | -0.9 | -0.8 | -0.4 | -1.2 | -1.2 | 1.6 | -0.4 | -1.2 |
| Compulsive drug intake | 1.1 | 1.1 | 1.6 | 1.2 | 1.3 | -1.2 | 1.0 | 1.0 | 0.1 | 1.2 | 0.9 |
| Locomotion distance, session 1 | 1.1 | 1.4 | 2.3 | -1.2 | -1.3 | 1.3 | -1.0 | -1.5 | -0.6 | -1.4 | -0.9 |
| Diff in mean of infusions in LGA sessions | 1.1 | 1.2 | 1.6 | 1.2 | 1.3 | -1.3 | 1.1 | 1.1 | -0.3 | 1.1 | 1.1 |
| Total resting periods, locomotor time 2 | 1.1 | 1.2 | 2.3 | 1.0 | 1.1 | -1.5 | 0.7 | 1.0 | 1.0 | 1.4 | 0.5 |
| Cu content in liver | 1.1 | 1.3 | 2.2 | -1.0 | -1.1 | 0.2 | -1.5 | -1.4 | 1.1 | -0.8 | -1.4 |
| Right kidney weight | 1.0 | 3.0 | 4.8 | -1.6 | -1.8 | 2.2 | -1.5 | -2.0 | -1.2 | -1.9 | -1.4 |
| Locomotor testing rearing | 1.0 | 1.6 | 2.8 | -1.2 | -1.3 | 1.7 | -1.0 | -1.3 | -0.8 | -1.5 | -0.9 |
| Intermitt. access escalation Index | 1.0 | 0.9 | 1.4 | 1.0 | 1.1 | -1.2 | 0.7 | 1.0 | 0.6 | 1.1 | 0.6 |
| Short access day 10 total locomotion | 1.0 | 1.1 | 1.9 | -1.1 | -1.1 | 1.4 | -1.2 | -0.8 | 0.7 | -1.0 | -1.2 |
| Locomotion velocity, session 8 | 1.0 | 1.2 | 4.4 | -0.9 | -1.0 | 2.1 | -0.9 | -0.7 | -0.0 | -1.0 | -0.9 |
| Degree of sensitization distance | 1.0 | 1.0 | 5.2 | -0.2 | -0.2 | 0.7 | 0.8 | -0.2 | -2.3 | -0.9 | 0.8 |
| Time in novel zone, hab. session 1 | 1.0 | 1.0 | 2.0 | -1.1 | -1.1 | 1.3 | -0.6 | -0.6 | -0.8 | -1.4 | -0.4 |
| Time in novel zone, hab. session 2 | 1.0 | 1.0 | 1.6 | -1.0 | -1.0 | 1.3 | -1.0 | -0.8 | 0.9 | -0.8 | -1.1 |
| Bone: endosteal estimation | 1.0 | 2.1 | 3.5 | -1.5 | -1.4 | 1.9 | -1.2 | -1.7 | -0.3 | -1.5 | -1.6 |
| Bone: marrow area | 1.0 | 2.1 | 3.5 | -1.5 | -1.4 | 1.9 | -1.2 | -1.7 | -0.4 | -1.5 | -1.5 |
| Bouts of movement, locomotor time 2 | 1.0 | 1.1 | 2.0 | 1.0 | 1.1 | -1.4 | 0.8 | 1.0 | 0.6 | 1.4 | 0.6 |
| Co content in liver | 1.0 | 1.1 | 1.9 | -1.1 | -1.0 | 1.4 | -1.3 | -0.9 | 0.7 | -0.9 | -1.1 |
| Mn content in liver | 1.0 | 1.1 | 2.2 | -0.9 | -1.0 | 0.9 | -1.5 | -1.1 | 0.8 | -0.7 | -1.3 |
| Length without tail | 0.9 | 2.0 | 2.7 | -1.4 | -1.5 | 1.6 | -1.5 | -1.6 | -0.2 | -1.5 | -1.3 |
| Delay discounting total patch changes 24 sec | 0.9 | 1.1 | 6.1 | 0.0 | -0.0 | 0.6 | 1.1 | -0.0 | -2.5 | -0.7 | 1.0 |
| Intermittent access day 15 total infusions | 0.9 | 1.0 | 1.6 | -1.3 | -1.3 | 0.5 | -0.9 | -1.2 | 0.2 | -1.1 | -1.0 |
| One hour access (0.3 mA shock) | 0.9 | 1.1 | 2.2 | -1.2 | -1.3 | 0.4 | -1.0 | -1.5 | 0.1 | -1.2 | -0.9 |
| Total zone transitions, hab. session 1 | 0.9 | 1.3 | 1.9 | -1.1 | -1.2 | 1.3 | -1.0 | -1.4 | -0.5 | -1.2 | -0.9 |
| Time in familiar zone, hab. session 2 | 0.9 | 1.0 | 1.3 | 1.0 | 1.0 | -1.1 | 1.1 | 0.9 | -0.8 | 0.8 | 1.1 |
| Bone: minimum diameter | 0.9 | 1.7 | 2.3 | -1.3 | -1.3 | 1.4 | -1.5 | -1.4 | 0.6 | -1.1 | -1.5 |
| Delta time to tail flick, test, before/after SA | 0.9 | 0.8 | 4.2 | 0.4 | 0.4 | 0.2 | 1.0 | 0.3 | -2.1 | -0.2 | 0.9 |
| Locomotion in novel chamber post-restriction | 0.9 | 1.1 | 1.9 | -0.7 | -0.7 | 1.4 | -1.3 | -0.5 | 1.3 | -0.6 | -1.3 |
| Food seeking constrained by brief footshock | 0.9 | 1.1 | 2.1 | -1.0 | -1.1 | 1.0 | -0.5 | -1.2 | -1.4 | -1.4 | -0.3 |
| BMI with tail | 0.8 | 2.6 | 4.3 | -1.8 | -1.5 | 1.2 | -2.1 | -1.5 | 1.4 | -1.2 | -2.1 |
| Std. dev. time between licks in bursts | 0.8 | 1.0 | 1.6 | -1.0 | -1.0 | 1.3 | -1.0 | -1.0 | 0.4 | -0.9 | -1.1 |
| Delay discounting total patch changes 6 sec | 0.8 | 1.3 | 2.2 | -1.1 | -1.2 | 1.5 | -0.6 | -1.2 | -1.0 | -1.5 | -0.6 |
| Reaction time mean minus median | 0.8 | 1.1 | 1.6 | 1.1 | 1.0 | -0.9 | 1.3 | 1.0 | -0.7 | 0.8 | 1.3 |
| Intermittent access terminal intake (last 3 days) | 0.8 | 0.9 | 1.5 | -1.2 | -1.2 | 0.5 | -0.7 | -1.1 | -0.3 | -1.2 | -0.7 |
| Time to tail flick, test, after self-admin | 0.8 | 0.9 | 1.9 | 0.9 | 0.8 | -0.3 | 1.1 | 0.7 | -1.4 | 0.4 | 1.2 |
| Rest time, locomotor task time 2 | 0.8 | 0.9 | 1.7 | 0.9 | 0.9 | -1.3 | 0.5 | 1.0 | 1.2 | 1.1 | 0.6 |
| Mg content in liver | 0.8 | 0.8 | 1.6 | -0.8 | -0.9 | 0.5 | -1.3 | -1.2 | 0.5 | -0.7 | -1.1 |
| Liver weight, left | 0.7 | 1.2 | 2.6 | -0.8 | -1.0 | 1.4 | -0.2 | -1.1 | -1.6 | -1.3 | -0.3 |
| Light reinforcement 1 | 0.7 | 1.3 | 1.7 | -1.3 | -1.2 | 1.1 | -1.2 | -1.2 | 0.3 | -1.1 | -1.3 |
| Conditioned reinforcement - actives | 0.7 | 0.7 | 1.1 | -0.9 | -0.9 | 0.3 | -1.0 | -1.0 | 0.6 | -0.8 | -0.9 |
| Short access total locomotion | 0.7 | 0.8 | 2.5 | -0.9 | -0.9 | 1.6 | -0.7 | -0.3 | 0.1 | -1.0 | -0.6 |
| Locomotion velocity, session 3 | 0.7 | 0.8 | 2.3 | -0.4 | -0.3 | 1.2 | -1.0 | -0.1 | 1.5 | 0.1 | -1.1 |
| Degree of sensitization stereotypy | 0.7 | 0.7 | 3.4 | -0.3 | -0.2 | -0.5 | -0.9 | -0.4 | 1.8 | 0.3 | -1.0 |
| Condit. Reinf. active-inactive response ratio | 0.7 | 0.8 | 1.1 | -1.0 | -1.1 | 0.5 | -1.0 | -1.0 | 0.2 | -1.0 | -0.8 |
| Time in familiar zone, hab. session 1 | 0.7 | 0.7 | 1.1 | 1.0 | 1.1 | -0.8 | 0.8 | 0.7 | 0.2 | 1.1 | 0.7 |
| Bone: post-yield work | 0.7 | 0.9 | 1.3 | 1.1 | 1.1 | -0.5 | 1.2 | 0.8 | -1.0 | 0.9 | 1.0 |
| Bone: trabecular thickness | 0.7 | 0.8 | 1.1 | -1.0 | -1.0 | 1.0 | -1.0 | -0.9 | 0.2 | -1.0 | -0.9 |
| Time to tail flick, vehicle, before self-admin | 0.7 | 0.7 | 4.8 | -0.1 | -0.0 | 0.3 | 0.7 | -0.0 | -2.2 | -0.5 | 0.6 |
| Rest time, locomotor task time 1 | 0.7 | 0.7 | 1.1 | 1.0 | 1.0 | -1.0 | 0.8 | 0.9 | 0.1 | 0.9 | 0.8 |
| Delay discounting total patch changes 18 sec | 0.6 | 0.8 | 3.8 | 0.4 | 0.3 | 0.2 | 1.0 | 0.3 | -2.0 | -0.2 | 0.9 |
| Delay discounting water rate 24 sec | 0.6 | 0.8 | 1.2 | -1.0 | -1.0 | 0.9 | -1.1 | -1.0 | 0.1 | -0.7 | -1.1 |
| Stereotopy head waving duration, day 7 | 0.6 | 0.8 | 1.4 | 0.9 | 1.0 | -0.8 | 0.5 | 1.1 | 0.7 | 1.2 | 0.5 |
| Total zone transitions, NPP test | 0.6 | 0.8 | 1.1 | -1.0 | -1.0 | 0.8 | -1.0 | -1.0 | 0.3 | -0.9 | -1.0 |
| Pavlov. Cond. magazine entry latency | 0.6 | 0.8 | 2.0 | -0.9 | -1.0 | -0.1 | -0.7 | -1.4 | -0.6 | -1.1 | -0.5 |
| Bone: maximum force | 0.6 | 1.1 | 1.6 | -1.1 | -1.1 | 1.3 | -1.0 | -1.2 | 0.0 | -1.1 | -1.0 |
| Breakpoint value in progressive ratio session | 0.6 | 0.7 | 1.4 | -0.7 | -0.7 | 0.4 | -1.2 | -0.8 | 1.1 | -0.6 | -1.1 |
| Epididymis fat weight | 0.5 | 1.2 | 1.8 | -1.2 | -1.1 | 0.9 | -1.3 | -1.1 | 0.6 | -1.0 | -1.3 |
| Indifference point 0 sec | 0.5 | 0.7 | 2.1 | -0.5 | -0.7 | 1.2 | -0.2 | -0.7 | -1.5 | -1.0 | -0.1 |
| Indifference point function ln k | 0.5 | 0.7 | 1.2 | -0.8 | -0.9 | 1.1 | -0.7 | -0.9 | -0.6 | -0.9 | -0.6 |
| Indifference point function log k | 0.5 | 0.7 | 1.2 | -0.8 | -0.9 | 1.1 | -0.7 | -0.9 | -0.6 | -0.9 | -0.6 |
| Delay discounting total patch changes 0 sec | 0.5 | 0.8 | 2.3 | -0.6 | -0.8 | 1.3 | -0.2 | -0.8 | -1.5 | -1.0 | -0.1 |
| Reaction time omissions | 0.5 | 0.6 | 0.9 | -0.8 | -0.9 | 0.7 | -1.0 | -0.8 | 0.5 | -0.9 | -0.6 |
| Social response proportion | 0.5 | 0.5 | 0.9 | -0.6 | -0.8 | 1.0 | -0.8 | -0.9 | 0.0 | -0.8 | -0.5 |
| Condit. Reinf. inactive responses | 0.5 | 0.6 | 0.9 | -0.8 | -0.8 | 0.9 | -0.9 | -0.8 | 0.2 | -0.8 | -0.7 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.0 | 0.7 | 0.8 | -0.8 | 0.9 | 0.8 | -0.5 | 0.6 | 1.0 |
| Intermittent access intake escalation 2 | 0.5 | 0.5 | 0.9 | -0.9 | -0.9 | 0.5 | -0.8 | -0.7 | 0.3 | -0.8 | -0.7 |
| Progressive ratio test 2 active lever presses | 0.5 | 0.5 | 1.3 | -0.9 | -0.9 | 0.0 | -0.6 | -1.1 | -0.3 | -0.9 | -0.5 |
| Novelty place preference | 0.5 | 0.5 | 2.5 | 0.1 | 0.1 | 1.6 | 0.6 | 0.8 | -0.6 | -0.2 | 0.5 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.4 | 0.7 | 0.7 | 0.8 | 0.8 | 1.2 | -0.4 | 0.5 | 0.8 |
| Pavlov. Cond. response bias | 0.5 | 0.6 | 1.6 | -0.9 | -0.9 | -0.2 | -0.8 | -1.2 | -0.1 | -0.8 | -0.7 |
| Bone: cortical thickness | 0.5 | 0.8 | 1.5 | -1.0 | -0.9 | 0.6 | -1.2 | -0.7 | 0.9 | -0.6 | -0.9 |
| Bone: elastic displacement | 0.5 | 0.6 | 1.8 | 0.5 | 0.6 | -1.0 | 0.0 | 0.6 | 1.3 | 1.0 | -0.1 |
| Bone: trabecular spacing | 0.5 | 0.6 | 1.0 | 0.7 | 0.8 | -1.0 | 0.9 | 0.9 | -0.0 | 0.7 | 1.0 |
| Time in closed arm before self-admin | 0.5 | 0.6 | 0.9 | 0.9 | 0.9 | -0.7 | 0.8 | 0.8 | -0.4 | 0.7 | 0.7 |
| Delay disc. indifference point, 16s delay | 0.5 | 0.5 | 1.8 | 0.6 | 0.6 | -1.4 | 0.7 | 0.3 | -0.3 | 0.6 | 0.7 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 2.0 | -0.2 | -0.2 | -0.8 | -0.6 | -0.7 | 1.4 | 0.2 | -0.7 |
| Delay discounting water rate 18 sec | 0.4 | 0.5 | 0.9 | -0.7 | -0.8 | 0.7 | -1.0 | -0.8 | 0.0 | -0.5 | -0.9 |
| Locomotor activity | 0.4 | 0.7 | 1.1 | -0.9 | -0.8 | 0.8 | -1.0 | -0.8 | 0.4 | -0.8 | -1.0 |
| Light reinforcement 2 | 0.4 | 0.5 | 0.7 | -0.8 | -0.8 | 0.6 | -0.7 | -0.8 | 0.5 | -0.8 | -0.8 |
| Conditioned locomotion | 0.4 | 0.4 | 0.5 | -0.7 | -0.7 | 0.6 | -0.6 | -0.7 | 0.5 | -0.7 | -0.7 |
| Intermittent access standard deviation | 0.4 | 0.4 | 0.7 | -0.8 | -0.8 | -0.2 | -0.6 | -0.8 | 0.3 | -0.7 | -0.6 |
| Novel to familiar place preference ratio | 0.4 | 0.4 | 2.3 | -0.2 | -0.2 | 1.5 | 0.3 | 0.4 | -0.7 | -0.4 | 0.3 |
| Time in novel zone, NPP test | 0.4 | 0.5 | 2.7 | -0.1 | -0.0 | 1.6 | 0.4 | 0.7 | -0.5 | -0.3 | 0.3 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 0.8 | -0.7 | -0.7 | 0.4 | -0.3 | -0.8 | -0.6 | -0.9 | -0.3 |
| Bone: tissue strength | 0.4 | 0.4 | 0.7 | -0.7 | -0.7 | 0.7 | -0.3 | -0.5 | -0.5 | -0.9 | -0.3 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 0.7 | -0.6 | -0.7 | 0.9 | -0.6 | -0.8 | -0.5 | -0.7 | -0.5 |
| Time to tail flick, test, before self-admin | 0.4 | 0.4 | 1.5 | -0.5 | -0.5 | 0.1 | -0.8 | -0.4 | 1.2 | -0.1 | -0.7 |
| Area under the delay curve | 0.4 | 0.4 | 0.8 | 0.7 | 0.7 | -0.9 | 0.6 | 0.4 | 0.2 | 0.7 | 0.5 |
| Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 1.4 | 0.4 | 0.4 | -1.1 | 0.1 | -0.0 | 1.2 | 0.6 | 0.0 |
| Delay discount exponential model param | 0.4 | 0.4 | 0.8 | -0.7 | -0.7 | 0.9 | -0.5 | -0.4 | -0.3 | -0.7 | -0.5 |
| Delay discount hyperbolic model param | 0.4 | 0.4 | 0.8 | -0.7 | -0.7 | 0.9 | -0.5 | -0.4 | -0.4 | -0.7 | -0.5 |
| Vertical activity count, locomotor time 2 | 0.4 | 0.5 | 1.3 | -0.5 | -0.5 | 1.0 | -0.2 | -0.6 | -1.1 | -0.8 | -0.1 |
| Locomotion in novel chamber | 0.4 | 0.4 | 0.7 | -0.7 | -0.6 | 0.8 | -0.6 | -0.7 | 0.4 | -0.6 | -0.9 |
| Glucose | 0.3 | 0.5 | 0.7 | -0.7 | -0.8 | 0.8 | -0.6 | -0.8 | 0.0 | -0.8 | -0.7 |
| Soleus weight | 0.3 | 0.9 | 1.7 | -1.0 | -0.9 | 1.3 | -0.8 | -1.1 | -0.3 | -1.0 | -0.9 |
| Food consumed during 24 hour testing period | 0.3 | 0.4 | 1.2 | 0.5 | 0.4 | 0.1 | 0.8 | 0.6 | -1.1 | 0.2 | 0.8 |
| Mean time between licks in bursts | 0.3 | 0.4 | 0.9 | 0.8 | 0.8 | -0.7 | 0.3 | 0.5 | 0.6 | 0.9 | 0.3 |
| Indifference point AUC | 0.3 | 0.3 | 0.5 | -0.7 | -0.7 | 0.6 | -0.5 | -0.6 | 0.0 | -0.7 | -0.6 |
| Reaction time mean minus median AUC | 0.3 | 0.4 | 0.7 | 0.6 | 0.5 | -0.6 | 0.8 | 0.6 | -0.5 | 0.3 | 0.8 |
| Median of all reaction times | 0.3 | 0.4 | 0.5 | -0.7 | -0.6 | 0.4 | -0.6 | -0.5 | 0.6 | -0.6 | -0.7 |
| Cocaine response before conditioning | 0.3 | 0.3 | 0.6 | 0.6 | 0.5 | -0.8 | 0.4 | 0.7 | 0.1 | 0.6 | 0.6 |
| Intermittent access day 1 total infusions | 0.3 | 0.3 | 0.4 | 0.6 | 0.5 | -0.6 | 0.6 | 0.6 | 0.0 | 0.5 | 0.6 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.9 | -0.6 | -0.6 | 1.0 | -0.4 | -0.4 | 0.0 | -0.7 | -0.4 |
| Lifetime Intake | 0.3 | 0.3 | 0.6 | -0.7 | -0.7 | 0.5 | -0.4 | -0.6 | 0.0 | -0.8 | -0.4 |
| Incentive Sensitization - Breakpoint | 0.3 | 0.3 | 1.6 | 0.1 | 0.0 | -1.3 | 0.1 | -0.6 | -0.3 | 0.2 | 0.1 |
| Progressive ratio test 2 breakpoint | 0.3 | 0.3 | 1.0 | -0.7 | -0.7 | -0.4 | -0.4 | -1.0 | -0.1 | -0.6 | -0.3 |
| One hour access (shock baseline) | 0.3 | 0.4 | 0.8 | -0.7 | -0.8 | 0.0 | -0.5 | -0.9 | 0.1 | -0.7 | -0.4 |
| Condit. Reinf. active minus inactive responses | 0.3 | 0.3 | 0.6 | -0.6 | -0.6 | 0.1 | -0.8 | -0.3 | 0.8 | -0.3 | -0.6 |
| Bone: maximum moment | 0.3 | 0.6 | 1.0 | -0.8 | -0.8 | 1.0 | -0.6 | -0.9 | -0.1 | -0.8 | -0.7 |
| Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 0.6 | 0.7 | 0.6 | -0.5 | 0.7 | 0.5 | 0.1 | 0.7 | 0.5 |
| Delta distance traveled before/after self-admin | 0.3 | 0.3 | 0.8 | 0.5 | 0.5 | -0.7 | 0.3 | 0.5 | 0.9 | 0.6 | 0.1 |
| Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 0.7 | 0.5 | 0.6 | -0.8 | 0.4 | 0.4 | 0.7 | 0.6 | 0.3 |
| Vertical activity count, locomotor time 1 | 0.3 | 0.3 | 0.6 | -0.6 | -0.6 | 0.8 | -0.4 | -0.5 | 0.2 | -0.6 | -0.5 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.3 | 1.0 | -0.3 | -0.4 | -0.7 | -0.3 | -1.0 | 0.3 | -0.1 | -0.5 |
| Cd content in liver | 0.3 | 0.4 | 0.6 | -0.8 | -0.7 | 0.8 | -0.6 | -0.3 | 0.3 | -0.7 | -0.5 |
| Fe content in liver | 0.3 | 0.4 | 0.8 | -0.7 | -0.6 | 0.9 | -0.4 | -0.6 | -0.4 | -0.7 | -0.5 |
| Parametrial fat weight | 0.2 | 0.5 | 0.9 | 0.5 | 0.6 | -1.0 | 0.7 | 0.8 | -0.3 | 0.6 | 0.7 |
| Number of licking bursts | 0.2 | 0.2 | 0.4 | -0.5 | -0.3 | 0.7 | -0.1 | -0.2 | 0.4 | -0.3 | -0.6 |
| Times rat made contact with spout | 0.2 | 0.2 | 1.0 | 0.1 | 0.1 | 1.0 | 0.2 | 0.7 | -0.2 | 0.1 | 0.2 |
| Mean num. licks in bursts | 0.2 | 0.3 | 0.7 | 0.5 | 0.3 | -0.1 | 0.3 | 0.5 | -0.8 | 0.2 | 0.8 |
| Reaction time number correct | 0.2 | 0.3 | 1.1 | -0.3 | -0.4 | 0.7 | -0.2 | -0.5 | -1.0 | -0.5 | -0.2 |
| Reaction time trials correct on left | 0.2 | 0.3 | 1.1 | -0.3 | -0.4 | 0.7 | -0.2 | -0.5 | -1.0 | -0.5 | -0.2 |
| Reaction time trials on left | 0.2 | 0.4 | 1.0 | -0.4 | -0.5 | 0.8 | -0.3 | -0.6 | -1.0 | -0.5 | -0.3 |
| Reaction time trials completed | 0.2 | 0.4 | 1.0 | -0.4 | -0.5 | 0.8 | -0.3 | -0.6 | -1.0 | -0.5 | -0.3 |
| Reaction time trials AUC | 0.2 | 0.3 | 1.1 | -0.3 | -0.4 | 0.7 | -0.3 | -0.5 | -1.0 | -0.5 | -0.2 |
| Cocaine response after cond. not corrected | 0.2 | 0.2 | 0.5 | 0.5 | 0.4 | -0.3 | 0.5 | 0.4 | -0.7 | 0.3 | 0.6 |
| Intermittent access total infusions | 0.2 | 0.3 | 0.6 | -0.6 | -0.6 | 0.2 | -0.2 | -0.7 | -0.4 | -0.8 | -0.2 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 1.3 | 0.0 | -0.0 | -1.1 | -0.0 | -0.6 | -0.0 | 0.2 | -0.0 |
| Short access day 1 total inactive lever presses | 0.2 | 0.3 | 0.4 | -0.6 | -0.7 | 0.3 | -0.5 | -0.6 | -0.2 | -0.6 | -0.5 |
| Incentive salience index mean | 0.2 | 0.3 | 0.5 | -0.6 | -0.7 | 0.3 | -0.6 | -0.6 | 0.0 | -0.6 | -0.4 |
| Pavlov. Cond. lever latency | 0.2 | 0.2 | 1.1 | 0.1 | 0.2 | -0.6 | -0.3 | -0.1 | 1.0 | 0.4 | -0.4 |
| Pavlov. Cond. index score | 0.2 | 0.2 | 0.5 | -0.4 | -0.5 | -0.2 | -0.1 | -0.6 | -0.7 | -0.6 | 0.0 |
| Pavlov. Cond. latency score | 0.2 | 0.3 | 1.2 | -0.3 | -0.5 | 0.1 | 0.1 | -0.5 | -1.1 | -0.6 | 0.3 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.5 | -0.5 | -0.6 | 0.2 | -0.2 | -0.6 | -0.7 | -0.7 | -0.0 |
| Pavlov. Cond. intertrial magazine entries | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | 0.5 | -0.6 | -0.4 | 0.7 | -0.3 | -0.6 |
| Bone: cortical apparent density | 0.2 | 0.3 | 1.6 | -0.0 | 0.0 | -0.7 | -0.3 | 0.3 | 1.3 | 0.3 | -0.1 |
| Bone: cortical tissue density | 0.2 | 0.3 | 1.4 | 0.1 | 0.1 | -0.8 | -0.2 | 0.4 | 1.2 | 0.4 | 0.0 |
| Active lever presses in extinction session 6 | 0.2 | 0.2 | 1.0 | 0.4 | 0.4 | -0.1 | 0.4 | 0.2 | -1.0 | 0.1 | 0.5 |
| Distance moved, locomotor task time 2 | 0.2 | 0.2 | 1.1 | -0.1 | -0.1 | -0.2 | 0.3 | -0.4 | -1.0 | -0.4 | 0.3 |
| Seeking ratio, delayed vs. immediate footshock | 0.2 | 0.2 | 0.4 | 0.2 | 0.3 | 0.1 | 0.5 | 0.7 | -0.5 | 0.1 | 0.5 |
| Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 0.7 | -0.3 | -0.3 | -0.0 | -0.0 | -0.8 | -0.9 | -0.5 | -0.0 |
| Zn content in liver | 0.2 | 0.2 | 0.8 | -0.3 | -0.5 | -0.4 | -0.4 | -0.9 | -0.4 | -0.5 | -0.1 |
| Retroperitoneal fat weight | 0.1 | 0.3 | 1.6 | -0.4 | -0.3 | 0.4 | 0.0 | -0.3 | -1.3 | -0.5 | -0.1 |
| Intraocular pressure | 0.1 | 0.2 | 0.8 | -0.1 | 0.0 | 0.0 | -0.3 | -0.2 | 0.9 | 0.2 | -0.5 |
| Extensor digitorum longus weight | 0.1 | 0.4 | 1.0 | -0.6 | -0.5 | 0.4 | -0.6 | -0.5 | 1.0 | -0.2 | -0.8 |
| Water consumed over 24 hours | 0.1 | 0.1 | 0.5 | 0.1 | 0.1 | 0.7 | 0.1 | 0.7 | 0.1 | 0.2 | 0.0 |
| Locomotor testing distance | 0.1 | 0.2 | 0.5 | -0.3 | -0.3 | 0.4 | -0.1 | -0.2 | -0.7 | -0.5 | -0.1 |
| Reaction time premature initiation rate | 0.1 | 0.2 | 0.5 | -0.4 | -0.3 | 0.3 | -0.4 | -0.5 | 0.5 | -0.2 | -0.7 |
| Reaction time premature initiations | 0.1 | 0.2 | 0.3 | -0.4 | -0.4 | 0.5 | -0.4 | -0.5 | -0.2 | -0.3 | -0.5 |
| Std. dev. reaction times | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | 0.1 | -0.4 | -0.3 | 0.4 | -0.3 | -0.4 |
| Social time | 0.1 | 0.2 | 0.8 | -0.1 | -0.1 | 0.0 | -0.6 | -0.2 | 0.9 | 0.1 | -0.3 |
| Cocaine response after cond. corrected | 0.1 | 0.1 | 0.6 | 0.2 | 0.2 | 0.0 | 0.3 | 0.2 | -0.8 | -0.0 | 0.4 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.4 | -0.3 | -0.3 | 0.6 | -0.3 | -0.5 | -0.2 | -0.4 | -0.3 |
| Pavlov. Cond. intertrial magazine entries | 0.1 | 0.1 | 0.6 | -0.0 | 0.0 | 0.0 | 0.5 | 0.0 | -0.8 | -0.2 | 0.3 |
| Total sessions with >9 infusions | 0.1 | 0.1 | 0.6 | -0.1 | 0.0 | 0.2 | -0.0 | 0.5 | 0.8 | 0.1 | -0.1 |
| Short access day 1 total infusions | 0.1 | 0.1 | 0.3 | -0.0 | -0.0 | 0.5 | 0.0 | 0.4 | 0.3 | -0.0 | 0.0 |
| Short access total infusions | 0.1 | 0.1 | 0.3 | -0.2 | -0.1 | 0.5 | -0.0 | 0.3 | 0.5 | -0.2 | -0.1 |
| Short access day 1 locomotion | 0.1 | 0.1 | 0.4 | 0.2 | 0.2 | 0.4 | 0.4 | 0.6 | -0.3 | -0.1 | 0.5 |
| Number of responses in last shaping day | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.4 | 0.2 | 0.5 | 0.1 | 0.2 | 0.2 |
| Locomotion velocity, session 1 | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | -0.0 | 0.1 | 0.5 | 0.0 | 0.3 | 0.5 |
| Locomotion velocity, session 2 | 0.1 | 0.2 | 0.4 | 0.6 | 0.5 | -0.0 | 0.2 | 0.4 | 0.2 | 0.6 | 0.2 |
| Stereotopy head waving bouts, day 7 | 0.1 | 0.1 | 0.4 | 0.3 | 0.3 | 0.1 | -0.1 | 0.5 | 0.7 | 0.5 | -0.1 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.4 | -0.5 | -0.4 | 0.4 | -0.2 | -0.4 |
| Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 | -0.4 | 0.2 | -0.2 | -0.5 | -0.0 | 0.2 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | 0.3 | -0.3 | -0.4 | -0.3 | -0.4 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.3 | -0.3 | -0.4 | -0.2 | -0.1 | -0.5 | -0.6 | -0.5 | 0.0 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.4 | -0.2 | -0.2 | 0.1 | -0.5 | -0.2 | 0.6 | 0.1 | -0.4 |
| Bone: elastic work | 0.1 | 0.2 | 0.7 | 0.1 | 0.2 | -0.6 | -0.1 | 0.3 | 0.9 | 0.4 | -0.2 |
| Time in open arm before self-admin | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | -0.5 | 0.3 | 0.3 | 0.3 | 0.4 | 0.2 |
| Delay disc. indifference point, 2s delay | 0.1 | 0.1 | 0.2 | 0.4 | 0.4 | -0.2 | 0.3 | 0.2 | 0.1 | 0.4 | 0.3 |
| Fecal boli incidents, locomotor time 1 | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | -0.3 | 0.0 | 0.4 | 0.7 | 0.6 | -0.0 |
| K content in liver | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | -0.1 | -0.4 | -0.4 | 0.2 | 0.1 | -0.3 |
| Na content in liver | 0.1 | 0.2 | 0.8 | 0.4 | 0.3 | -0.1 | 0.3 | -0.0 | -0.9 | 0.2 | 0.4 |
| Liver weight, right | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | -0.3 | 0.3 | 0.3 | -0.5 | 0.1 | 0.3 |
| Delay discounting total patch changes 12 sec | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.0 | 0.0 | 0.1 | -0.0 | 0.2 | 0.1 |
| Reaction time mean | 0.0 | 0.1 | 0.2 | -0.2 | -0.2 | 0.0 | -0.2 | -0.1 | 0.4 | -0.2 | -0.3 |
| Reaction time mean AUC | 0.0 | 0.0 | 0.2 | -0.2 | -0.2 | 0.0 | -0.2 | -0.1 | 0.4 | -0.2 | -0.2 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.2 | 0.3 | 0.3 | 0.2 | 0.1 | 0.2 |
| Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | 0.2 | 0.4 | 0.2 | -0.1 |
| Time to tail flick, vehicle, after self-admin | 0.0 | 0.0 | 0.1 | -0.0 | 0.1 | -0.1 | 0.0 | -0.1 | 0.2 | 0.1 | -0.1 |
| Change in fecal boli incidents, locomotor task | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.5 | 0.1 | -0.1 | 0.0 | 0.2 | 0.2 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.1 | -0.2 | 0.3 | -0.1 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.