Hub : Genes

Cd72

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000017485	0.02	0.02	9.5e-03	0.02	0.01	0.01	0.01	5.0e-03	2.1e-02	1.6e-02	9.2e-03
2	Adipose	mRNA stability	ENSRNOG00000017485	0.13	0.09	3.3e-13	0.12	0.12	0.12	0.12	1.1e-13	2.4e-13	2.4e-13	1.7e-13
3	IL	gene expression	ENSRNOG00000017485	0.16	0.1	3.3e-04	0.24	0.14	0.16	0.19	1.8e-06	3.5e-04	9.2e-05	2.8e-05
4	NAcc	gene expression	ENSRNOG00000017485	0.06	0.04	6.6e-05	0.06	0.06	0.05	0.06	2.4e-05	4.4e-05	8.9e-05	4.5e-05
5	PL	gene expression	ENSRNOG00000017485	0.05	0.04	1.5e-04	0.04	0.04	0.04	0.04	3.9e-04	3.2e-04	4.4e-04	7.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	3.4	11.2	13.3	-2.9	3.5	3.6	3.6	2.9
BMI without tail	5.2	10.8	15.2	-3.3	3.5	2.8	2.8	3.9
Body weight	3.7	15.5	17.7	-3.8	3.9	3.9	3.9	4.2
Epididymis fat weight	0.2	0.5	1.4	-1.0	0.3	0.2	0.2	1.2
Glucose	1.1	1.6	2.2	-1.3	1.2	1.2	1.2	1.5
Heart weight	0.4	0.6	1.2	-1.0	0.7	0.5	0.5	1.1
Left kidney weight	0.3	0.8	1.7	-0.9	0.8	0.7	0.7	1.3
Right kidney weight	0.1	0.2	0.4	-0.1	-0.0	-0.6	-0.6	0.2
Tail length	1.6	4.7	9.9	-2.5	2.2	1.2	1.2	3.1
Length with tail	0.4	1.4	3.8	-1.4	0.7	0.6	0.7	2.0
Length without tail	0.3	0.7	1.3	0.9	-1.1	-0.6	-0.5	-1.0
Liver weight, left	0.3	0.4	0.7	-0.8	-0.5	-0.6	-0.6	0.8
Liver weight, right	0.5	0.8	1.3	0.4	-1.1	-1.1	-1.1	-0.3
Parametrial fat weight	0.0	0.1	0.4	-0.1	0.1	-0.1	-0.1	0.6
Retroperitoneal fat weight	0.1	0.2	0.3	0.3	-0.3	-0.5	-0.6	-0.6
Intraocular pressure	1.7	2.4	4.0	-1.2	1.4	1.5	1.5	2.0
Extensor digitorum longus weight	4.3	17.1	22.2	-4.3	4.0	3.8	3.8	4.7
Soleus weight	1.0	2.9	5.1	1.1	-1.8	-2.2	-2.3	-0.1
Tibialis anterior weight	5.0	17.3	28.7	-4.4	3.8	3.5	3.4	5.4
Tibia length	0.7	2.0	3.8	0.8	-1.5	-1.9	-1.9	0.0
Number of licking bursts	4.5	5.3	6.2	-2.4	2.2	2.2	2.2	2.5
Food consumed during 24 hour testing period	0.4	0.4	1.2	-0.8	0.4	0.3	0.3	1.1
Times rat made contact with spout	0.8	1.0	1.5	-0.7	1.1	1.2	1.2	0.6
Mean time between licks in bursts	1.5	2.2	3.5	0.7	-1.6	-1.9	-1.9	-0.9
Mean num. licks in bursts	1.7	2.1	3.3	1.6	-1.3	-1.2	-1.2	-1.8
Std. dev. time between licks in bursts	0.6	0.7	1.0	0.6	-0.8	-1.0	-1.0	-0.7
Water consumed over 24 hours	1.2	1.4	1.8	-0.9	1.2	1.3	1.3	1.0
Indifference point 0 sec	0.3	0.5	0.8	0.2	0.6	0.9	0.9	0.8
Indifference point AUC	7.4	8.7	11.9	-3.2	2.7	2.7	2.6	3.5
Indifference point function ln k	2.5	3.6	4.5	2.0	-1.8	-1.7	-1.7	-2.1
Indifference point function log k	2.5	3.6	4.5	2.0	-1.8	-1.7	-1.7	-2.1
Delay discounting total patch changes 0 sec	0.7	1.2	1.8	-0.2	1.0	1.3	1.3	1.2
Delay discounting total patch changes 12 sec	3.4	4.6	6.2	-1.6	2.1	2.5	2.5	1.9
Delay discounting total patch changes 18 sec	0.7	0.9	1.3	-0.8	0.8	1.0	0.9	1.1
Delay discounting total patch changes 24 sec	2.9	3.7	4.2	-1.5	1.9	2.1	2.0	2.0
Delay discounting total patch changes 6 sec	2.9	4.5	5.4	-1.6	2.2	2.2	2.2	2.3
Delay discounting time to switch 0 sec	2.8	4.2	5.8	1.8	-2.0	-2.0	-2.0	-2.4
Delay discounting water rate 0 sec	2.4	3.8	5.2	-1.1	2.0	2.3	2.3	1.9
Delay discounting water rate 12 sec	0.0	0.0	0.0	0.2	-0.2	0.1	0.1	0.2
Delay discounting water rate 18 sec	1.1	1.5	2.6	-0.7	1.2	1.6	1.6	0.7
Delay discounting water rate 24 sec	0.6	0.8	1.4	-0.2	1.0	1.1	1.2	-0.0
Delay discounting water rate 6 sec	0.4	0.6	1.0	-0.5	0.7	0.8	0.8	1.0
Locomotor activity	0.0	0.0	0.1	-0.3	0.0	-0.1	-0.1	0.1
Locomotor testing distance	0.3	0.5	0.8	0.4	-0.9	-0.9	-0.9	-0.1
Locomotor testing rearing	0.2	0.4	1.1	-0.7	0.2	0.2	0.2	1.1
Light reinforcement 1	0.4	0.7	1.7	0.0	-0.6	-0.9	-0.9	1.3
Light reinforcement 2	1.0	1.3	2.0	0.9	-1.2	-1.4	-1.4	0.6
Reaction time number correct	0.1	0.1	0.1	-0.1	0.2	0.4	0.3	0.4
Reaction time mean minus median	0.9	1.1	2.4	-1.6	1.1	0.9	1.0	0.6
Reaction time mean minus median AUC	1.4	1.8	3.2	-1.8	1.3	1.2	1.2	1.1
Reaction time num false alarms	0.1	0.2	0.5	-0.6	0.7	0.3	0.2	0.1
Reaction time num false alarms AUC	0.5	0.7	1.2	-0.9	1.1	0.7	0.6	0.7
Reaction time trials correct on left	0.1	0.1	0.1	-0.1	0.2	0.4	0.3	0.4
Reaction time trials on left	0.0	0.0	0.1	-0.0	0.2	0.3	0.2	0.3
Reaction time mean	0.7	1.0	1.9	0.5	-0.8	-1.1	-1.0	-1.4
Reaction time mean AUC	0.8	1.1	2.2	0.6	-0.8	-1.1	-1.0	-1.5
Median of all reaction times	2.5	3.4	4.4	1.5	-1.6	-2.0	-1.9	-2.1
Reaction time omissions	1.8	2.4	3.0	1.2	-1.5	-1.7	-1.7	-1.5
Reaction time false alarm rate	0.0	0.1	0.2	-0.3	0.4	0.1	0.0	-0.1
Reaction time premature initiation rate	1.1	1.5	3.6	1.4	-1.2	-0.5	-0.6	-1.9
Reaction time premature initiations	0.7	0.9	2.2	1.2	-0.9	-0.2	-0.3	-1.5
Std. dev. reaction times	0.1	0.1	0.4	-0.7	0.2	-0.0	-0.0	-0.3
Reaction time trials completed	0.0	0.0	0.1	-0.0	0.2	0.3	0.2	0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.0	0.2	0.3	0.3	0.3
Social response proportion	3.0	3.2	4.1	1.4	-1.8	-2.0	-2.0	-1.7
Social responses	0.3	0.4	0.9	-0.9	0.5	0.3	0.3	0.9
Social time	1.6	2.1	4.1	0.4	-1.4	-2.0	-2.0	-0.4
Conditioned locomotion	0.1	0.1	0.4	0.6	-0.2	-0.1	-0.1	-0.1
Cocaine response after cond. corrected	2.6	2.9	4.0	2.0	-1.8	-1.7	-1.7	-1.4
Cocaine response after cond. not corrected	3.1	3.5	4.2	1.8	-2.1	-2.0	-2.0	-1.2
Cocaine response before conditioning	0.4	0.5	1.1	-1.1	0.4	0.3	0.3	1.0
Saline control response	0.2	0.3	1.3	-0.4	0.1	0.2	0.2	1.1
Condit. Reinf. active minus inactive responses	0.9	1.1	1.3	-1.0	1.1	1.1	1.1	1.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	-0.5	0.8	0.9	0.9	0.3
Condit. Reinf. active responses	2.2	3.1	3.8	-2.0	1.6	1.6	1.6	2.0
Condit. Reinf. inactive responses	2.8	3.4	5.0	-2.2	1.7	1.6	1.6	2.0
Condit. Reinf. lever presses	2.7	3.8	5.1	-2.3	1.9	1.8	1.8	1.8
Condit. Reinf. lever reinforcers received	2.6	3.6	4.6	-2.1	1.8	1.7	1.7	2.1
Pavlov. Cond. lever latency	2.9	4.0	5.7	2.4	-1.9	-1.8	-1.8	-2.0
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	0.4	-1.0	-1.1	-1.1	-0.8
Pavlov. Cond. change in total contacts	0.8	1.2	2.3	-1.5	1.0	0.9	0.9	0.9
Pavlov. Cond. index score	0.2	0.3	0.8	-0.9	0.4	0.3	0.3	0.4
Pavlov. Cond. latency score	0.5	0.6	1.1	-1.1	0.8	0.7	0.7	0.5
Pavlov. Cond. lever contacts	1.4	2.0	3.1	-1.8	1.3	1.2	1.2	1.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.6	-0.3	-0.1	-0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.1	-0.6	0.9	1.0	1.1	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.9	0.4	0.3	0.3	0.4
Pavlov. Cond. response bias	0.5	0.7	1.5	-1.2	0.7	0.6	0.6	0.8
Conditioned reinforcement - actives	0.9	0.9	1.6	-0.4	1.0	1.2	1.3	0.3
Conditioned reinforcement - inactives	0.0	0.1	0.1	0.3	0.1	0.3	0.2	-0.3
Conditioned locomotion	1.4	1.6	3.0	-0.5	1.4	1.7	1.7	0.6
Intermittent access intake day 1-15 change	1.1	1.1	1.4	-1.2	1.0	1.0	1.2	0.7
Intermittent access intake escalation	1.6	1.6	2.1	-1.3	1.3	1.2	1.5	1.0
Intermittent access intake escalation 2	2.3	2.3	3.3	-1.4	1.6	1.6	1.8	1.0
Intermitt. access day 1 inactive lever presses	0.9	1.0	1.2	-0.9	1.0	1.1	1.0	0.9
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.2	0.2	0.1
Intermitt. access escalation Index	0.4	0.4	1.3	-0.5	0.1	0.3	0.4	1.1
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.8	-0.1	0.1	0.1	-0.6
Intermittent access day 15 total infusions	1.4	1.6	2.7	-0.8	1.3	1.5	1.6	0.7
Intermittent access terminal intake (last 3 days)	1.8	2.0	3.5	-0.8	1.5	1.7	1.9	0.8
Intermittent access total infusions	1.9	2.1	3.4	-0.8	1.6	1.8	1.9	0.9
Intermittent access day 1 locomotion	0.4	0.4	1.0	1.0	0.1	0.2	0.1	-0.9
Intermittent access day 15 total locomotion	0.3	0.4	0.8	0.7	0.2	0.5	0.5	-0.9
Intermittent access total locomotion	0.6	0.7	1.1	0.4	0.8	1.0	1.0	-0.7
Intermittent access standard deviation	0.6	0.6	0.8	-0.8	0.7	0.9	0.9	0.5
Cocaine induced anxiety	1.6	1.8	2.5	1.6	-1.5	-1.2	-1.2	-1.3
Post-drug Anxiety	0.2	0.3	0.4	-0.2	-0.6	-0.5	-0.5	0.6
Baseline Anxiety	1.7	1.8	3.5	-1.9	1.4	1.0	1.0	1.4
Lifetime Intake	1.3	1.5	2.3	-0.5	1.4	1.5	1.5	0.9
Incentive Sensitization - Responses	0.0	0.0	0.2	0.4	-0.1	-0.1	-0.0	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.1	-0.3
Progressive ratio test 1 active lever presses	0.9	1.0	1.9	-0.0	1.0	1.4	1.3	0.3
Progressive ratio test 1 breakpoint	1.1	1.1	2.2	-0.2	1.1	1.5	1.4	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	0.1	0.3	0.4	0.4	0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.4	0.2	0.5	0.6	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.6	0.1	0.5	0.5	-0.3
Progressive ratio test 2 inactive lever presses	0.5	0.5	1.0	-0.2	0.7	1.0	1.0	0.4
Total sessions with >9 infusions	0.1	0.1	0.3	0.5	0.1	0.1	0.2	-0.1
Short access day 1 total inactive lever presses	2.5	2.8	3.7	-0.9	1.8	1.9	1.9	1.5
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.3	0.0	0.2	0.3	0.5
Short access day 1 total infusions	0.8	0.9	1.1	-0.2	1.1	1.1	1.0	1.0
Short access day 10 total infusions	0.6	0.6	1.0	-0.1	1.0	0.9	0.9	0.7
Short access total infusions	0.2	0.2	0.3	0.3	0.6	0.5	0.5	0.3
Short access day 1 locomotion	0.2	0.2	0.5	0.7	0.3	0.4	0.2	-0.4
Short access day 10 total locomotion	0.2	0.2	0.8	0.4	0.2	0.2	0.1	-0.9
Short access total locomotion	0.2	0.2	0.3	0.3	0.6	0.5	0.5	0.1
Compulsive drug intake	0.3	0.3	0.7	-0.8	0.3	0.1	0.4	0.6
One hour access (0.3 mA shock)	0.7	0.8	1.2	-0.6	0.8	1.0	1.1	0.8
One hour access (shock baseline)	0.7	0.8	1.4	-0.1	0.9	1.2	1.1	0.6
Number of responses in last shaping day	0.2	0.3	0.5	0.7	-0.6	-0.4	-0.4	0.3
Context. condit. distance diff. score	0.0	0.1	0.1	0.2	0.1	0.2	0.2	-0.4
Locomotion velocity, session 1	0.3	0.3	0.6	0.4	-0.5	-0.5	-0.5	0.8
Locomotion distance, session 1	0.1	0.1	0.4	-0.0	-0.2	-0.3	-0.3	0.7
Locomotion velocity, session 2	2.7	3.2	3.9	-2.0	1.9	1.6	1.6	1.8
Locomotion distance, session 2	0.7	1.0	3.3	-1.3	0.5	0.1	0.1	1.8
Locomotion velocity, session 3	0.2	0.2	0.3	0.3	-0.5	-0.5	-0.5	0.2
Locomotion distance, session 3	2.3	2.5	3.1	-1.2	1.6	1.6	1.6	1.8
Stereotopy head waving bouts, day 3	0.9	1.1	1.7	0.8	-1.3	-1.3	-1.3	-0.3
Stereotopy head waving duration, day 3	1.0	1.2	1.7	0.9	-1.3	-1.2	-1.2	-0.6
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.3
Locomotion distance, session 7	0.2	0.2	0.3	-0.3	0.5	0.5	0.5	0.6
Stereotopy head waving bouts, day 7	2.1	2.4	3.0	-1.4	1.5	1.5	1.5	1.7
Stereotopy head waving duration, day 7	0.2	0.3	0.8	-0.6	0.3	0.2	0.2	0.9
Locomotion velocity, session 8	0.8	0.9	1.7	0.3	-1.0	-1.3	-1.3	0.1
Locomotion distance, session 8	0.1	0.1	0.3	-0.1	-0.3	-0.4	-0.4	0.5
Degree of sensitization distance	1.5	1.5	1.8	1.0	-1.3	-1.4	-1.4	-1.2
Degree of sensitization stereotypy	1.7	1.9	2.2	-1.1	1.4	1.5	1.5	1.3
Condit. Reinf. active minus inactive responses	0.5	0.5	0.9	-1.0	0.7	0.5	0.5	0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.7	-0.7	-0.6	-0.6	-0.9
Condit. Reinf. active responses	2.7	3.3	5.0	-2.2	1.7	1.5	1.5	2.0
Condit. Reinf. inactive responses	3.1	3.7	6.2	-2.5	1.8	1.5	1.5	2.2
Incentive salience index mean	3.9	4.7	6.4	-2.5	2.0	1.8	1.8	2.5
Condit. Reinf. lever presses	8.5	11.4	17.0	-3.8	3.1	2.8	2.8	4.1
Time in familiar zone, hab. session 1	0.8	0.8	1.3	-0.2	1.0	1.2	1.2	-0.6
Time in novel zone, hab. session 1	6.1	6.0	8.8	1.8	-2.7	-3.0	-3.0	-1.2
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.1
Total locomotion distance, hab. session 1	0.5	0.7	1.5	-1.2	0.9	0.7	0.7	0.7
Locomotion velocity, hab. session 1	1.7	2.4	3.9	-2.0	1.6	1.3	1.3	1.5
Time in familiar zone, hab. session 2	0.2	0.2	0.8	0.3	-0.2	-0.2	-0.2	-0.9
Time in novel zone, hab. session 2	2.2	2.2	2.8	1.7	-1.5	-1.5	-1.5	-1.1
Total zone transitions, hab. session 2	0.2	0.2	0.8	-0.5	0.3	0.1	0.1	0.9
Total locomotion distance, hab. session 2	0.7	0.9	1.2	-1.1	0.9	0.7	0.7	1.1
Locomotion velocity, hab. session 2	1.0	1.3	1.7	-1.3	1.2	1.0	1.0	1.3
Novel to familiar place preference ratio	4.2	4.4	5.2	2.3	-2.2	-2.1	-2.1	-1.9
Novelty place preference	5.3	5.5	6.6	2.6	-2.4	-2.2	-2.2	-2.3
Time in novel zone, NPP test	6.7	7.1	8.1	2.8	-2.7	-2.6	-2.6	-2.5
Total zone transitions, NPP test	0.2	0.3	1.2	-0.6	0.2	-0.1	-0.1	1.1
Total locomotion distance, NPP test	1.3	1.8	3.2	-1.4	1.2	1.1	1.1	1.8
Locomotion velocity, NPP test	2.1	3.0	4.3	-1.7	1.7	1.6	1.6	2.1
Pavlov. Cond. lever latency	6.1	7.8	11.4	3.1	-2.6	-2.4	-2.4	-3.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.9	0.5	0.3	0.3	0.8
Pavlov. Cond. change in total contacts	2.2	2.4	3.5	-1.7	1.4	1.3	1.3	1.9
Pavlov. Cond. index score	2.6	3.4	5.1	-2.3	1.7	1.4	1.4	2.2
Pavlov. Cond. latency score	2.6	3.3	4.7	-2.2	1.7	1.5	1.5	2.1
Pavlov. Cond. lever contacts	5.3	6.3	7.8	-2.7	2.4	2.3	2.3	2.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	1.1	-0.8	-0.6	-0.6	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.7	0.4	0.2	0.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	5.1	-2.3	1.7	1.5	1.5	2.1
Pavlov. Cond. response bias	2.7	3.3	4.6	-2.1	1.7	1.5	1.5	2.1
Bone: apparent density	1.7	2.8	3.3	-1.5	1.7	1.8	1.8	1.5
Bone surface	0.7	1.2	1.5	-0.9	1.1	1.1	1.1	1.2
Bone volume	0.8	1.3	1.5	-0.9	1.2	1.2	1.2	1.2
Bone: connectivity density	1.2	1.9	2.4	-1.2	1.5	1.6	1.6	1.0
Bone: cortical apparent density	0.1	0.2	0.2	-0.2	0.5	0.5	0.5	-0.3
Bone: cortical area	2.2	3.4	3.9	-2.0	1.9	1.7	1.7	1.9
Bone: cortical porosity	0.4	0.4	0.6	0.6	-0.7	-0.6	-0.6	-0.7
Bone: cortical porosity	0.0	0.0	0.0	-0.0	0.1	0.2	0.2	-0.0
Bone: cortical thickness	1.4	2.2	2.9	-1.3	1.7	1.7	1.7	1.0
Bone: cortical thickness	0.1	0.1	0.1	0.3	-0.1	-0.3	-0.3	-0.4
Bone: cortical tissue density	0.1	0.1	0.2	-0.1	0.3	0.3	0.3	-0.4
Bone: elastic displacement	2.5	2.8	6.1	2.0	-1.3	-1.1	-1.1	-2.5
Bone: elastic work	0.5	0.7	2.8	0.8	-0.1	0.0	0.0	-1.7
Bone: endosteal estimation	0.4	0.9	2.7	-1.1	0.6	0.4	0.4	1.6
Bone: endosteal perimeter	0.5	1.0	2.8	-1.1	0.6	0.5	0.5	1.7
Bone: final force	0.7	1.1	2.3	-1.3	0.9	0.7	0.7	1.5
Bone: final moment	0.5	0.8	1.6	-1.2	0.7	0.5	0.5	1.3
Bone: marrow area	0.5	1.1	2.9	-1.2	0.7	0.6	0.6	1.7
Bone: maximum diameter	1.7	3.2	4.9	-2.1	1.6	1.4	1.4	2.2
Bone: maximum force	2.0	3.6	5.6	-2.3	1.7	1.4	1.4	2.4
Bone: maximum moment	1.6	2.7	4.2	-2.0	1.6	1.2	1.2	2.0
Bone: minimum diameter	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.1
Bone: periosteal estimation	0.9	1.9	3.8	-1.6	1.2	0.9	0.9	1.9
Bone: periosteal perimeter	0.2	0.3	1.1	-0.6	0.3	0.2	0.2	1.0
Bone: post-yield work	0.6	0.8	2.4	-1.2	0.5	0.2	0.2	1.5
Bone: stiffness	2.3	3.6	7.0	-2.5	1.5	1.1	1.1	2.6
Bone: tissue strength	0.3	0.3	0.5	-0.5	-0.4	-0.7	-0.7	0.3
Bone: trabecular number	1.6	2.5	2.7	-1.6	1.6	1.6	1.6	1.4
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	0.2	0.2	0.2	-0.1
Bone: trabecular thickness	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	-0.3
Bone: trabecular tissue density	1.2	1.7	4.0	-1.9	0.7	0.4	0.4	2.0
Breakpoint value in progressive ratio session	0.5	0.6	1.0	1.0	-0.8	-0.8	-0.8	-0.4
Distance traveled before self-admin	2.8	3.0	5.8	-1.7	1.5	1.3	1.5	2.4
Distance traveled after self-admin	0.4	0.4	1.1	-1.1	0.6	0.1	0.1	0.8
Delta time in closed arm before/after self-admin	3.4	3.3	5.1	-2.3	1.7	1.6	1.7	1.6
Delta time in open arm before/after self-admin	0.7	0.6	0.9	0.6	-0.9	-0.8	-1.0	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2	-0.2
Extinction: sum of active levers before priming	2.0	2.0	2.6	1.1	-1.3	-1.5	-1.6	-1.5
Active lever presses in extinction session 6	0.2	0.2	0.4	0.5	-0.1	-0.2	-0.3	-0.6
Delta distance traveled before/after self-admin	1.1	1.2	2.0	0.6	-1.0	-1.3	-1.4	-1.0
Delta ambulatory time before/after self-admin	2.4	2.6	3.9	1.1	-1.5	-1.8	-2.0	-1.5
Time in closed arm before self-admin	1.6	1.8	3.4	1.8	-1.0	-0.8	-0.9	-1.8
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	-0.0	0.2	0.1	-0.4
Time in open arm before self-admin	1.2	1.2	3.1	-1.2	1.0	0.6	0.6	1.8
Time in open arm after self-admin	0.9	1.0	1.6	-1.0	1.0	0.8	0.8	1.3
Sum of active levers in priming session hrs 5-6	3.1	3.0	3.8	1.9	-1.6	-1.6	-1.6	-1.9
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.6	1.0	-0.4	-0.4	-0.5	-1.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.0	0.1	0.0	-0.0
Time to tail flick, test, before self-admin	0.6	0.6	1.0	-0.6	0.8	0.9	1.0	0.5
Time to tail flick, test, after self-admin	1.8	1.8	2.7	-1.1	1.4	1.6	1.6	0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	-0.1	-0.0	-0.0	0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	0.2	0.2	0.1	-0.2
Ambulatory time before self-admin	2.1	2.2	4.3	-1.4	1.3	1.2	1.3	2.1
Ambulatory time after self-admin	0.1	0.2	0.3	-0.5	0.2	-0.4	-0.4	0.4
Total heroin consumption	0.6	0.7	0.9	0.9	-0.9	-0.8	-0.9	-0.6
Area under the delay curve	0.5	0.6	0.8	0.5	-0.8	-0.8	-0.9	-0.7
Delay disc. indifference point, 0s delay	1.8	1.9	2.4	1.3	-1.4	-1.5	-1.6	-1.2
Delay disc. indifference point, 16s delay	1.3	1.4	1.8	1.3	-1.2	-1.1	-1.1	-1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.4	0.2	0.3	0.5	0.1
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.3	-0.6	-0.6	-0.6	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.4	-0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.5	0.0	-0.1	-0.1	0.1
Delay discount exponential model param	0.4	0.4	0.6	-0.5	0.7	0.7	0.8	0.6
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.4	0.6	0.6	0.7	0.5
Fecal boli incidents, locomotor time 1	0.3	0.3	0.8	0.4	-0.4	-0.5	-0.4	-0.9
Change in fecal boli incidents, locomotor task	0.6	0.6	1.1	-0.1	0.7	0.8	0.8	1.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.3	0.1
Bouts of movement, locomotor time 1	1.9	2.2	2.6	1.4	-1.2	-1.6	-1.6	-1.5
Total resting periods, locomotor time 1	2.1	2.3	3.1	1.4	-1.3	-1.5	-1.6	-1.8
Rest time, locomotor task time 1	0.6	0.7	2.0	0.5	-0.5	-0.7	-0.7	-1.4
Distance moved, locomotor task time 1	0.9	1.0	2.6	-0.6	0.8	0.8	0.9	1.6
Vertical activity count, locomotor time 1	0.3	0.3	1.4	-0.1	-0.3	-0.3	-0.1	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.4	-0.1	-0.2	-0.3	0.3
Bouts of movement, locomotor time 2	0.6	0.6	1.0	-1.0	1.0	0.5	0.3	0.8
Total resting periods, locomotor time 2	0.3	0.4	0.7	-0.7	0.9	0.4	0.3	0.5
Rest time, locomotor task time 2	0.6	0.8	1.5	1.2	-0.7	-0.4	-0.7	-1.1
Distance moved, locomotor task time 2	0.3	0.4	1.0	-1.0	0.4	0.2	0.4	0.7
Vertical activity count, locomotor time 2	0.3	0.3	0.6	-0.7	-0.1	-0.4	-0.3	0.8
Weight adjusted by age	0.0	0.0	0.2	0.0	-0.1	-0.0	0.1	0.4
Seeking ratio, delayed vs. immediate footshock	5.5	6.3	7.6	-2.7	2.8	2.4	2.5	2.1
Locomotion in novel chamber	0.2	0.3	0.4	-0.4	0.6	0.5	0.6	-0.1
Locomotion in novel chamber post-restriction	2.4	2.9	3.3	-1.8	1.8	1.8	1.7	1.4
Progressive ratio	0.0	0.0	0.0	-0.0	0.0	0.0	-0.1	-0.1
Food seeking constrained by brief footshock	5.6	6.8	10.7	-2.5	2.4	2.4	2.4	3.3
Seeking ratio, punishment vs. effort	1.3	1.6	2.8	-1.2	1.1	1.1	1.3	1.7
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.3	0.4	0.5	0.6	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.2	0.4	0.2	0.2	-0.1
Latency to leave start box in cocaine runway	1.0	1.1	1.4	-0.8	1.1	1.2	1.1	0.9
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.2	0.1	0.2	0.2	-0.1
Latency to leave start box in cocaine runway, M	0.8	0.8	1.6	-0.7	0.8	0.7	0.7	1.3
Cd content in liver	0.6	0.6	0.9	-0.9	0.9	0.6	0.6	0.9
Co content in liver	2.2	2.6	3.7	1.8	-1.9	-1.5	-1.5	-1.2
Cu content in liver	1.2	1.5	1.8	1.0	-1.3	-1.2	-1.2	-1.2
Fe content in liver	0.9	1.1	2.0	0.6	-1.0	-1.4	-1.4	0.3
K content in liver	0.6	0.6	0.8	0.9	-0.9	-0.8	-0.8	-0.5
Mg content in liver	0.4	0.4	0.7	0.8	-0.8	-0.5	-0.5	-0.7
Mn content in liver	0.3	0.3	0.5	-0.7	0.5	0.6	0.6	0.4
Na content in liver	3.2	3.4	4.8	1.4	-2.0	-2.2	-2.2	-1.4
Rb content in liver	4.4	5.5	7.1	2.7	-2.4	-2.1	-2.1	-2.5
Se content in liver	1.5	1.8	4.1	-2.0	1.3	0.7	0.7	1.5
Sr content in liver	0.5	0.4	1.2	-1.1	0.4	0.4	0.4	0.7
Zn content in liver	0.3	0.4	0.6	-0.5	0.8	0.7	0.7	0.2