Ppme1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	ENSRNOG00000017227	0.24	0.13	0.0e+00	0.18	0.21	0.21	0.21	1.7e-16	1.8e-19	2.7e-19	1.7e-19
2	Liver	gene expression	ENSRNOG00000017227	0.03	0.02	1.4e-03	0.01	0.01	0.01	0.01	1.0e-02	2.1e-02	3.3e-02	2.7e-02
3	PL	mRNA stability	ENSRNOG00000017227	0.05	0.04	3.0e-03	0.03	0.03	0.03	0.02	4.7e-03	4.3e-03	1.7e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.1	0.2	0.6	0.2	-0.8	0.2
BMI without tail	0.3	0.7	1.6	-0.7	-1.3	-0.1
Body weight	0.3	1.1	3.2	-0.4	-1.8	0.2
Epididymis fat weight	1.1	2.5	4.4	0.9	-2.1	1.5
Glucose	0.1	0.1	0.2	-0.2	0.4	-0.2
Heart weight	1.4	2.0	2.4	-1.5	1.2	-1.5
Left kidney weight	0.4	1.1	2.6	-1.6	-0.4	-0.8
Right kidney weight	0.2	0.6	1.3	-1.1	-0.4	-0.5
Tail length	0.8	2.4	4.4	-2.1	-1.3	-1.0
Length with tail	0.4	1.3	2.9	-1.0	-1.7	-0.2
Length without tail	0.2	0.5	0.7	0.8	-0.5	0.7
Liver weight, left	1.3	2.1	3.6	1.0	-1.9	1.3
Liver weight, right	2.9	4.9	8.1	1.5	-2.8	2.1
Parametrial fat weight	1.5	2.9	4.4	1.3	-2.1	1.6
Retroperitoneal fat weight	5.8	19.1	30.2	3.2	-5.5	4.1
Intraocular pressure	0.5	0.7	1.3	-0.6	1.2	-0.7
Extensor digitorum longus weight	0.3	1.1	2.2	0.5	-1.5	0.9
Soleus weight	0.6	1.8	4.2	0.4	-2.0	1.0
Tibialis anterior weight	0.0	0.1	0.3	-0.4	-0.5	-0.1
Tibia length	2.6	7.2	8.1	-2.4	2.8	-2.8
Number of licking bursts	6.4	7.6	8.8	2.7	-2.6	3.0
Food consumed during 24 hour testing period	5.0	6.0	6.7	-2.4	2.4	-2.6
Times rat made contact with spout	0.7	0.8	1.4	0.5	-1.2	0.8
Mean time between licks in bursts	2.8	3.9	6.9	-2.6	0.2	-2.1
Mean num. licks in bursts	5.1	6.1	7.0	-2.5	2.2	-2.7
Std. dev. time between licks in bursts	0.5	0.6	1.2	-1.1	-0.6	-0.6
Water consumed over 24 hours	0.5	0.5	0.8	0.9	-0.3	0.8
Indifference point 0 sec	4.4	7.1	8.8	-3.0	2.1	-2.9
Indifference point AUC	0.1	0.2	0.4	-0.3	-0.6	0.2
Indifference point function ln k	2.1	3.0	4.5	-1.4	2.1	-1.6
Indifference point function log k	2.1	3.0	4.5	-1.4	2.1	-1.6
Delay discounting total patch changes 0 sec	3.4	5.5	7.0	-2.6	1.8	-2.5
Delay discounting total patch changes 12 sec	0.7	1.0	1.9	-1.4	0.1	-1.0
Delay discounting total patch changes 18 sec	2.0	2.7	4.0	-2.0	1.0	-1.8
Delay discounting total patch changes 24 sec	0.5	0.6	0.9	-1.0	-0.1	-0.9
Delay discounting total patch changes 6 sec	0.8	1.2	1.4	-1.2	1.0	-1.0
Delay discounting time to switch 0 sec	3.5	5.4	7.6	2.8	-1.6	2.5
Delay discounting water rate 0 sec	3.5	5.6	6.7	-2.6	1.9	-2.5
Delay discounting water rate 12 sec	2.6	3.9	5.0	-1.9	1.8	-2.2
Delay discounting water rate 18 sec	1.0	1.4	1.9	-1.3	0.7	-1.4
Delay discounting water rate 24 sec	2.1	2.8	4.3	-1.4	2.1	-1.6
Delay discounting water rate 6 sec	1.5	2.1	2.5	-1.3	1.5	-1.6
Locomotor activity	0.9	1.4	1.7	-1.3	1.2	-1.0
Locomotor testing distance	1.9	3.2	4.5	-2.1	1.3	-1.8
Locomotor testing rearing	0.4	0.6	1.4	-1.2	-0.1	-0.6
Light reinforcement 1	2.7	4.9	6.3	2.2	-1.9	2.5
Light reinforcement 2	0.1	0.2	0.3	0.5	0.0	0.5
Reaction time number correct	0.5	0.8	2.0	-0.4	1.4	-0.4
Reaction time mean minus median	0.6	0.8	1.3	-1.1	0.3	-0.9
Reaction time mean minus median AUC	1.3	1.7	2.2	-1.5	1.0	-1.4
Reaction time num false alarms	2.7	3.7	4.4	1.8	-1.9	2.1
Reaction time num false alarms AUC	1.3	1.8	2.2	1.3	-1.2	1.5
Reaction time trials correct on left	0.5	0.8	2.0	-0.4	1.4	-0.4
Reaction time trials on left	0.5	0.8	2.0	-0.4	1.4	-0.4
Reaction time mean	1.2	1.6	2.0	1.1	-1.4	1.3
Reaction time mean AUC	1.5	1.9	2.0	1.4	-1.4	1.4
Median of all reaction times	2.0	2.7	2.8	1.6	-1.6	1.7
Reaction time omissions	0.4	0.6	0.7	0.6	-0.8	0.8
Reaction time false alarm rate	2.1	3.0	3.6	1.5	-1.9	1.7
Reaction time premature initiation rate	0.7	0.9	1.7	-1.3	-0.6	-0.8
Reaction time premature initiations	0.8	1.2	2.2	-1.5	0.4	-1.1
Std. dev. reaction times	0.2	0.2	0.6	-0.4	-0.8	0.0
Reaction time trials completed	0.5	0.8	2.0	-0.4	1.4	-0.4
Reaction time trials AUC	0.4	0.6	1.6	-0.5	1.3	-0.4
Social response proportion	0.6	0.7	0.9	0.7	-1.0	0.7
Social responses	0.9	1.2	2.4	0.7	-1.6	0.9
Social time	2.5	3.2	4.8	2.2	-1.2	1.9
Conditioned locomotion	0.0	0.0	0.1	0.2	0.2	0.1
Cocaine response after cond. corrected	2.8	3.1	3.6	1.6	-1.9	1.8
Cocaine response after cond. not corrected	0.8	0.9	1.0	0.9	-1.0	0.9
Cocaine response before conditioning	2.7	3.3	3.9	-1.6	2.0	-1.9
Saline control response	1.6	2.1	3.1	-1.8	0.7	-1.6
Condit. Reinf. active minus inactive responses	6.4	7.9	11.4	-3.4	1.7	-3.1
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.4	-1.6	1.0	-1.5
Condit. Reinf. active responses	7.6	10.6	15.9	-4.0	1.8	-3.5
Condit. Reinf. inactive responses	3.9	4.8	7.7	-2.8	1.0	-2.4
Condit. Reinf. lever presses	17.2	23.7	30.3	-5.5	3.5	-5.4
Condit. Reinf. lever reinforcers received	9.0	12.7	18.6	-4.3	2.1	-3.9
Pavlov. Cond. lever latency	18.5	25.3	32.0	5.7	-3.8	5.5
Pavlov. Cond. magazine entry latency	5.1	5.8	6.7	-2.5	2.1	-2.6
Pavlov. Cond. change in total contacts	14.9	20.8	24.8	-5.0	3.7	-4.9
Pavlov. Cond. index score	14.7	19.2	23.4	-4.8	3.4	-4.8
Pavlov. Cond. latency score	13.4	16.9	20.5	-4.5	3.2	-4.5
Pavlov. Cond. lever contacts	19.1	26.6	33.3	-5.8	3.9	-5.6
Pavlov. Cond. magazine entry number	8.9	11.0	12.6	3.4	-2.9	3.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.4	0.1	-1.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	13.5	17.5	21.7	-4.7	3.2	-4.6
Pavlov. Cond. response bias	19.9	27.5	33.6	-5.8	4.1	-5.7
Conditioned reinforcement - actives	3.9	3.9	4.6	-1.8	2.0	-2.1
Conditioned reinforcement - inactives	0.4	0.5	0.8	0.7	-0.9	0.4
Conditioned locomotion	4.1	4.9	6.0	-1.9	2.5	-2.3
Intermittent access intake day 1-15 change	1.0	1.0	1.0	-0.9	1.0	-1.0
Intermittent access intake escalation	1.3	1.2	1.4	-1.1	1.2	-1.1
Intermittent access intake escalation 2	0.2	0.2	0.5	-0.7	0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.0	0.9	-1.0	0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.3	-0.2	0.5	-0.6
Intermitt. access escalation Index	0.6	0.5	0.6	-0.8	0.7	-0.7
Intermittent access day 1 total infusions	1.1	1.2	2.1	-1.1	0.6	-1.5
Intermittent access day 15 total infusions	2.1	2.3	3.2	-1.4	1.4	-1.8
Intermittent access terminal intake (last 3 days)	1.7	1.8	2.4	-1.4	1.1	-1.6
Intermittent access total infusions	1.0	1.1	2.0	-0.9	0.6	-1.4
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.2	0.4	-0.6
Intermittent access day 15 total locomotion	2.0	2.1	2.4	-1.3	1.5	-1.5
Intermittent access total locomotion	0.8	0.9	1.3	-1.0	0.7	-1.1
Intermittent access standard deviation	0.0	0.0	0.1	-0.3	-0.1	-0.1
Cocaine induced anxiety	2.1	2.4	3.4	1.5	-1.2	1.8
Post-drug Anxiety	1.3	1.4	1.7	1.0	-1.2	1.3
Baseline Anxiety	0.8	0.9	1.3	-1.0	0.6	-1.2
Lifetime Intake	1.3	1.5	2.7	-1.1	0.8	-1.6
Incentive Sensitization - Responses	2.3	2.3	4.1	-2.0	0.9	-1.4
Incentive Sensitization - Breakpoint	2.3	2.3	4.0	-2.0	1.0	-1.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	0.6	-0.4	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	0.5	-0.5	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.6	-0.2	-0.3	-0.8
Progressive ratio test 2 active lever presses	0.9	1.0	1.7	-1.3	0.5	-1.0
Progressive ratio test 2 breakpoint	0.9	1.0	1.8	-1.3	0.5	-1.0
Progressive ratio test 2 inactive lever presses	1.0	1.2	1.9	-1.0	0.8	-1.4
Total sessions with >9 infusions	3.0	3.2	5.4	-1.5	1.5	-2.3
Short access day 1 total inactive lever presses	0.2	0.3	0.6	0.8	-0.4	0.1
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.4	0.1	0.3
Short access day 1 total infusions	2.3	2.5	3.8	-1.6	0.9	-1.9
Short access day 10 total infusions	0.9	1.0	1.8	-1.1	0.4	-1.4
Short access total infusions	0.8	0.9	1.9	-0.9	0.2	-1.4
Short access day 1 locomotion	2.7	2.8	3.6	-1.4	1.7	-1.9
Short access day 10 total locomotion	0.4	0.4	0.8	-0.9	0.4	-0.5
Short access total locomotion	0.2	0.2	0.3	-0.4	0.3	-0.5
Compulsive drug intake	0.1	0.1	0.3	0.0	0.6	-0.0
One hour access (0.3 mA shock)	2.1	2.4	3.3	-1.6	1.2	-1.8
One hour access (shock baseline)	1.5	1.8	2.4	-1.5	0.9	-1.5
Number of responses in last shaping day	0.1	0.1	0.3	-0.6	-0.1	-0.3
Context. condit. distance diff. score	3.3	4.0	4.4	-1.9	2.0	-2.1
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	0.4	0.2
Locomotion distance, session 1	1.2	1.5	1.8	-1.1	1.4	-1.3
Locomotion velocity, session 2	0.0	0.0	0.1	-0.3	0.1	-0.2
Locomotion distance, session 2	0.6	0.8	0.9	-0.8	0.9	-0.9
Locomotion velocity, session 3	1.1	1.3	1.9	-0.9	1.4	-1.1
Locomotion distance, session 3	2.1	2.3	3.2	-1.3	1.8	-1.5
Stereotopy head waving bouts, day 3	0.6	0.7	1.1	0.7	-1.0	0.8
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.3	0.4	-0.3
Locomotion velocity, session 7	0.1	0.2	0.3	0.5	-0.1	0.4
Locomotion distance, session 7	0.2	0.2	0.2	0.5	-0.4	0.5
Stereotopy head waving bouts, day 7	3.4	3.8	4.2	-1.9	1.9	-2.0
Stereotopy head waving duration, day 7	3.7	4.5	5.1	-2.2	1.9	-2.2
Locomotion velocity, session 8	0.9	1.0	1.2	-1.0	1.0	-1.1
Locomotion distance, session 8	2.8	4.2	4.9	-2.0	1.9	-2.2
Degree of sensitization distance	2.0	2.0	3.7	0.9	-1.9	1.2
Degree of sensitization stereotypy	7.3	7.9	8.9	-2.8	2.7	-3.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.4	-0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.7	-0.2	-0.5
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	-0.3	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.0	0.2
Incentive salience index mean	0.1	0.1	0.3	-0.5	-0.1	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.4	0.1	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.0	-0.4	0.1
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.5	-0.4	0.6
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.0	0.7	-0.3
Total locomotion distance, hab. session 1	1.4	2.0	3.2	1.0	-1.8	1.3
Locomotion velocity, hab. session 1	0.7	1.1	1.8	0.7	-1.4	1.0
Time in familiar zone, hab. session 2	1.3	1.4	1.8	-1.3	0.7	-1.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.6	-0.1	0.5
Total zone transitions, hab. session 2	2.0	2.6	3.0	-1.4	1.7	-1.7
Total locomotion distance, hab. session 2	0.3	0.4	1.1	0.0	-1.1	0.3
Locomotion velocity, hab. session 2	0.5	0.7	1.8	0.2	-1.3	0.5
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	0.3	-0.3
Novelty place preference	0.1	0.1	0.1	-0.3	0.3	-0.3
Time in novel zone, NPP test	0.3	0.3	0.3	-0.6	0.5	-0.5
Total zone transitions, NPP test	0.4	0.6	0.9	-0.6	1.0	-0.7
Total locomotion distance, NPP test	0.8	1.1	2.0	0.6	-1.4	0.9
Locomotion velocity, NPP test	1.2	1.8	2.8	1.0	-1.7	1.3
Pavlov. Cond. lever latency	1.2	1.6	2.0	1.4	-0.9	1.4
Pavlov. Cond. magazine entry latency	2.8	3.6	4.7	-2.2	1.3	-2.1
Pavlov. Cond. change in total contacts	1.3	1.4	1.9	-1.4	0.8	-1.3
Pavlov. Cond. index score	2.7	3.5	4.7	-2.2	1.2	-2.1
Pavlov. Cond. latency score	2.7	3.4	4.6	-2.1	1.2	-2.0
Pavlov. Cond. lever contacts	1.0	1.2	1.8	-1.3	0.6	-1.2
Pavlov. Cond. magazine entry number	3.5	4.4	5.4	2.3	-1.5	2.3
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.6	1.3	-0.7	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	3.7	-1.9	1.1	-1.8
Pavlov. Cond. response bias	1.0	1.3	1.8	-1.3	0.6	-1.2
Bone: apparent density	0.0	0.1	0.1	0.2	0.4	0.1
Bone surface	0.8	1.3	1.7	-1.3	0.9	-1.3
Bone volume	0.5	0.9	1.0	-1.0	0.8	-1.0
Bone: connectivity density	0.2	0.3	0.7	-0.2	0.8	-0.4
Bone: cortical apparent density	2.7	3.5	3.8	1.7	-1.9	2.0
Bone: cortical area	0.2	0.3	0.6	-0.8	0.1	-0.6
Bone: cortical porosity	1.5	1.7	2.1	-1.1	1.5	-1.3
Bone: cortical porosity	1.3	1.4	2.0	-1.0	1.4	-1.2
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.2	0.4
Bone: cortical thickness	0.3	0.3	0.5	-0.4	0.7	-0.5
Bone: cortical tissue density	2.6	3.4	3.7	1.7	-1.9	1.9
Bone: elastic displacement	1.7	1.9	2.8	1.7	-0.7	1.6
Bone: elastic work	1.2	1.6	2.6	1.6	-0.5	1.4
Bone: endosteal estimation	0.7	1.4	2.6	-1.6	0.0	-1.3
Bone: endosteal perimeter	1.1	2.2	3.8	-1.9	0.5	-1.6
Bone: final force	0.0	0.0	0.0	0.1	-0.2	0.2
Bone: final moment	0.0	0.0	0.0	-0.2	-0.0	-0.1
Bone: marrow area	0.5	1.0	2.0	-1.4	-0.1	-1.1
Bone: maximum diameter	1.2	2.3	3.6	-1.9	0.7	-1.7
Bone: maximum force	0.0	0.0	0.0	-0.2	0.1	-0.1
Bone: maximum moment	0.1	0.1	0.2	-0.5	0.2	-0.4
Bone: minimum diameter	0.2	0.4	1.0	-0.6	-1.0	-0.1
Bone: periosteal estimation	0.6	1.3	2.3	-1.5	0.1	-1.2
Bone: periosteal perimeter	0.9	1.5	2.6	-1.6	0.5	-1.3
Bone: post-yield work	0.2	0.2	0.3	-0.4	0.4	-0.5
Bone: stiffness	0.4	0.6	0.9	0.6	-1.0	0.7
Bone: tissue strength	0.3	0.3	0.7	0.3	0.9	-0.0
Bone: trabecular number	0.5	0.7	1.2	1.1	-0.1	0.9
Bone: trabecular spacing	1.0	1.2	1.5	-1.2	0.9	-1.2
Bone: trabecular thickness	0.3	0.4	0.5	0.6	-0.6	0.7
Bone: trabecular tissue density	2.4	3.4	5.1	1.4	-2.3	1.8
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.3	0.1	0.3
Distance traveled before self-admin	1.4	1.5	2.2	1.1	-1.0	1.5
Distance traveled after self-admin	0.3	0.3	0.6	0.6	0.8	0.2
Delta time in closed arm before/after self-admin	3.2	3.1	5.3	0.9	-2.3	1.8
Delta time in open arm before/after self-admin	3.8	3.6	4.8	-2.0	1.5	-2.2
Diff in mean of infusions in LGA sessions	3.8	4.3	5.2	2.1	-1.8	2.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	-0.4	0.4
Active lever presses in extinction session 6	4.9	4.7	7.4	-1.8	2.7	-1.9
Delta distance traveled before/after self-admin	1.8	1.9	2.7	-0.9	1.5	-1.6
Delta ambulatory time before/after self-admin	2.1	2.3	3.1	-0.9	1.8	-1.7
Time in closed arm before self-admin	3.8	4.4	7.1	-1.4	2.7	-2.1
Time in closed arm after self-admin	0.4	0.4	0.8	0.9	0.2	0.7
Time in open arm before self-admin	5.1	5.4	7.4	2.0	-2.2	2.7
Time in open arm after self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.1	0.4	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.0	0.5	0.1
Time to tail flick, vehicle, after self-admin	3.0	3.2	4.8	-1.4	1.7	-2.2
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	-0.3	-0.4
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.5	-0.4	-0.2
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	3.1	-1.0	0.9	-1.8
Delta time to tail flick, test, before/after SA	0.3	0.2	0.3	0.4	-0.4	0.6
Ambulatory time before self-admin	1.3	1.3	1.9	1.2	-0.8	1.4
Ambulatory time after self-admin	0.5	0.6	1.5	0.4	1.2	-0.2
Total heroin consumption	0.5	0.6	0.7	-0.7	0.8	-0.8
Area under the delay curve	0.1	0.1	0.1	-0.1	-0.3	0.4
Delay disc. indifference point, 0s delay	0.7	0.7	1.2	-1.1	0.5	-0.9
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.1	0.1	0.2
Delay disc. indifference point, 2s delay	0.4	0.4	0.9	-1.0	-0.1	-0.5
Delay disc. indifference point, 24s delay	0.8	0.8	1.3	0.9	-0.6	1.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	-1.0	-0.2	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.4	0.1	0.0
Delay discount exponential model param	0.1	0.1	0.2	0.0	0.4	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.1	0.2	0.4	-0.3
Fecal boli incidents, locomotor time 1	1.5	1.6	2.4	-1.0	1.5	-1.2
Change in fecal boli incidents, locomotor task	1.6	1.5	1.8	1.4	-1.1	1.2
Time >=10cm from walls, locomotor time 1	2.8	2.8	2.9	-1.6	1.7	-1.7
Bouts of movement, locomotor time 1	0.4	0.4	0.5	-0.6	0.7	-0.6
Total resting periods, locomotor time 1	0.3	0.4	0.8	-0.3	0.9	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	0.4	-0.1
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.4	-0.6	0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.5	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	1.4	1.5	2.0	-1.4	0.8	-1.4
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.4	-0.4	-0.1
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.0	-0.7	0.2
Rest time, locomotor task time 2	3.3	3.9	5.1	2.3	-1.5	2.0
Distance moved, locomotor task time 2	3.2	3.7	5.7	-2.4	1.2	-2.0
Vertical activity count, locomotor time 2	0.9	1.0	1.9	-1.4	0.1	-1.0
Weight adjusted by age	0.2	0.2	0.5	-0.7	-0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	1.2	1.3	2.5	1.6	-0.7	1.0
Locomotion in novel chamber	1.7	2.1	4.0	-1.2	2.0	-1.0
Locomotion in novel chamber post-restriction	3.0	3.5	4.1	-1.6	2.0	-2.0
Progressive ratio	0.1	0.1	0.3	-0.2	0.5	-0.2
Food seeking constrained by brief footshock	0.5	0.6	1.4	-1.2	0.1	-0.7
Seeking ratio, punishment vs. effort	0.3	0.3	0.6	-0.8	-0.5	-0.4
Run reversals in cocaine runway, females	2.8	2.8	6.5	0.7	-2.5	1.2
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.4	-0.2	0.1
Latency to leave start box in cocaine runway	4.1	4.5	5.4	1.9	-2.3	2.1
Latency to leave start box in cocaine runway, F	3.9	4.3	6.3	1.6	-2.5	2.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.7	-0.0	0.5
Cd content in liver	1.0	1.1	1.6	0.8	-1.2	1.0
Co content in liver	1.0	1.1	1.9	-1.4	0.3	-1.2
Cu content in liver	0.4	0.5	0.9	-1.0	-0.2	-0.7
Fe content in liver	0.1	0.1	0.1	0.2	-0.3	0.2
K content in liver	0.4	0.4	0.6	0.5	-0.8	0.6
Mg content in liver	0.1	0.1	0.2	-0.4	0.1	-0.4
Mn content in liver	0.9	1.0	1.8	1.3	-0.1	1.1
Na content in liver	0.3	0.3	0.4	-0.5	0.5	-0.6
Rb content in liver	0.7	0.9	1.3	-1.1	0.6	-1.0
Se content in liver	3.3	4.0	5.3	2.3	-1.4	2.2
Sr content in liver	0.1	0.1	0.3	-0.1	0.5	-0.2
Zn content in liver	5.0	5.5	6.8	-2.6	1.7	-2.6